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to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}

{"project":"2_test","denotations":[{"id":"23459853-22837675-38778507","span":{"begin":153,"end":157},"obj":"22837675"},{"id":"23459853-20633539-38778508","span":{"begin":419,"end":423},"obj":"20633539"},{"id":"23459853-21909994-38778509","span":{"begin":506,"end":510},"obj":"21909994"},{"id":"23459853-22593187-38778510","span":{"begin":729,"end":733},"obj":"22593187"},{"id":"23459853-22156195-38778511","span":{"begin":1021,"end":1025},"obj":"22156195"},{"id":"23459853-21931801-38778512","span":{"begin":1243,"end":1247},"obj":"21931801"}],"text":"Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}

{"project":"UBERON-AE","denotations":[{"id":"T874","span":{"begin":803,"end":808},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}

{"project":"GO-BP","denotations":[{"id":"T2013","span":{"begin":1158,"end":1178},"obj":"http://purl.obolibrary.org/obo/GO_0008535"},{"id":"T2012","span":{"begin":1158,"end":1178},"obj":"http://purl.obolibrary.org/obo/GO_0004129"},{"id":"T2011","span":{"begin":867,"end":878},"obj":"http://purl.obolibrary.org/obo/GO_0016798"},{"id":"T2008","span":{"begin":821,"end":841},"obj":"http://purl.obolibrary.org/obo/GO_0006284"},{"id":"T2007","span":{"begin":194,"end":205},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T2006","span":{"begin":56,"end":67},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T2005","span":{"begin":646,"end":655},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T1996","span":{"begin":220,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0003908"},{"id":"T1995","span":{"begin":175,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0003908"},{"id":"T1994","span":{"begin":78,"end":82},"obj":"http://purl.obolibrary.org/obo/GO_0003908"},{"id":"T1990","span":{"begin":457,"end":469},"obj":"http://purl.obolibrary.org/obo/GO_0043066"},{"id":"T1982","span":{"begin":396,"end":405},"obj":"http://purl.obolibrary.org/obo/GO_0097194"}],"text":"Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}

{"project":"GO-MF","denotations":[{"id":"T2033","span":{"begin":1158,"end":1178},"obj":"http://purl.obolibrary.org/obo/GO_0004129"},{"id":"T2032","span":{"begin":1158,"end":1168},"obj":"http://purl.obolibrary.org/obo/GO_0045158"},{"id":"T2031","span":{"begin":1158,"end":1168},"obj":"http://purl.obolibrary.org/obo/GO_0045157"},{"id":"T2030","span":{"begin":1158,"end":1168},"obj":"http://purl.obolibrary.org/obo/GO_0045156"},{"id":"T2029","span":{"begin":1158,"end":1170},"obj":"http://purl.obolibrary.org/obo/GO_0045155"},{"id":"T2028","span":{"begin":1158,"end":1168},"obj":"http://purl.obolibrary.org/obo/GO_0045154"},{"id":"T2027","span":{"begin":1158,"end":1168},"obj":"http://purl.obolibrary.org/obo/GO_0045153"},{"id":"T2026","span":{"begin":867,"end":878},"obj":"http://purl.obolibrary.org/obo/GO_0016798"},{"id":"T2023","span":{"begin":220,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0003908"},{"id":"T2022","span":{"begin":175,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0003908"},{"id":"T2021","span":{"begin":78,"end":82},"obj":"http://purl.obolibrary.org/obo/GO_0003908"}],"text":"Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}

{"project":"GO-CC","denotations":[{"id":"T2047","span":{"begin":1058,"end":1075},"obj":"http://purl.obolibrary.org/obo/GO_0070469"},{"id":"T2046","span":{"begin":1044,"end":1075},"obj":"http://purl.obolibrary.org/obo/GO_0097249"},{"id":"T2045","span":{"begin":1044,"end":1075},"obj":"http://purl.obolibrary.org/obo/GO_0005746"},{"id":"T2038","span":{"begin":488,"end":493},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2037","span":{"begin":100,"end":105},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}

{"project":"sentences","denotations":[{"id":"T897","span":{"begin":1028,"end":1249},"obj":"Sentence"},{"id":"T896","span":{"begin":817,"end":1027},"obj":"Sentence"},{"id":"T895","span":{"begin":513,"end":816},"obj":"Sentence"},{"id":"T894","span":{"begin":426,"end":512},"obj":"Sentence"},{"id":"T893","span":{"begin":279,"end":425},"obj":"Sentence"},{"id":"T892","span":{"begin":160,"end":278},"obj":"Sentence"},{"id":"T891","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"T27","span":{"begin":0,"end":159},"obj":"Sentence"},{"id":"T28","span":{"begin":160,"end":278},"obj":"Sentence"},{"id":"T29","span":{"begin":279,"end":425},"obj":"Sentence"},{"id":"T30","span":{"begin":426,"end":512},"obj":"Sentence"},{"id":"T31","span":{"begin":513,"end":816},"obj":"Sentence"},{"id":"T32","span":{"begin":817,"end":1027},"obj":"Sentence"},{"id":"T33","span":{"begin":1028,"end":1249},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}

{"project":"simple1","denotations":[{"id":"T2065","span":{"begin":642,"end":645},"obj":"Protein"},{"id":"T2064","span":{"begin":426,"end":437},"obj":"Protein"},{"id":"T2063","span":{"begin":347,"end":356},"obj":"Protein"},{"id":"T2062","span":{"begin":331,"end":336},"obj":"Protein"},{"id":"T2061","span":{"begin":327,"end":330},"obj":"Protein"},{"id":"T2060","span":{"begin":307,"end":318},"obj":"Protein"},{"id":"T2059","span":{"begin":220,"end":224},"obj":"Protein"},{"id":"T2058","span":{"begin":175,"end":179},"obj":"Protein"},{"id":"T2057","span":{"begin":78,"end":82},"obj":"Protein"}],"text":"Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012). An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival. Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010). MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012). Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors. The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012). Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011)."}