PMC:3585731 / 49208-49509 JSONTXT

{"project":"testone","denotations":[{"id":"T20805","span":{"begin":15,"end":25},"obj":"Gene_expression"},{"id":"T20804","span":{"begin":5,"end":14},"obj":"Positive_regulation"},{"id":"T20761","span":{"begin":29,"end":33},"obj":"Protein"}],"relations":[{"id":"R13924","pred":"themeOf","subj":"T20761","obj":"T20805"},{"id":"R13934","pred":"themeOf","subj":"T20805","obj":"T20804"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"pmc-enju-pas","denotations":[{"id":"T22651","span":{"begin":295,"end":300},"obj":"NN"},{"id":"T22650","span":{"begin":287,"end":294},"obj":"NN"},{"id":"T22649","span":{"begin":283,"end":286},"obj":"CC"},{"id":"T22648","span":{"begin":275,"end":282},"obj":"NN"},{"id":"T22647","span":{"begin":269,"end":274},"obj":"NN"},{"id":"T22646","span":{"begin":260,"end":268},"obj":"JJ"},{"id":"T22645","span":{"begin":257,"end":259},"obj":"IN"},{"id":"T22644","span":{"begin":251,"end":256},"obj":"NN"},{"id":"T22643","span":{"begin":243,"end":250},"obj":"JJ"},{"id":"T22642","span":{"begin":239,"end":242},"obj":"DT"},{"id":"T22641","span":{"begin":236,"end":238},"obj":"VB"},{"id":"T22640","span":{"begin":230,"end":235},"obj":"NN"},{"id":"T22639","span":{"begin":225,"end":229},"obj":"NN"},{"id":"T22638","span":{"begin":216,"end":224},"obj":"JJ"},{"id":"T22637","span":{"begin":203,"end":215},"obj":"VB"},{"id":"T22636","span":{"begin":190,"end":202},"obj":"NN"},{"id":"T22635","span":{"begin":178,"end":189},"obj":"JJ"},{"id":"T22634","span":{"begin":172,"end":177},"obj":"WRB"},{"id":"T22633","span":{"begin":170,"end":171},"obj":"-COMMA-"},{"id":"T22632","span":{"begin":160,"end":170},"obj":"NN"},{"id":"T22631","span":{"begin":150,"end":159},"obj":"JJ"},{"id":"T22630","span":{"begin":144,"end":149},"obj":"JJ"},{"id":"T22629","span":{"begin":140,"end":143},"obj":"CC"},{"id":"T22628","span":{"begin":127,"end":139},"obj":"NN"},{"id":"T22627","span":{"begin":115,"end":126},"obj":"VB"},{"id":"T22626","span":{"begin":112,"end":114},"obj":"IN"},{"id":"T22625","span":{"begin":107,"end":111},"obj":"JJ"},{"id":"T22624","span":{"begin":105,"end":106},"obj":"-COMMA-"},{"id":"T22623","span":{"begin":97,"end":105},"obj":"NN"},{"id":"T22622","span":{"begin":85,"end":96},"obj":"VB"},{"id":"T22621","span":{"begin":79,"end":84},"obj":"JJ"},{"id":"T22620","span":{"begin":75,"end":78},"obj":"IN"},{"id":"T22619","span":{"begin":65,"end":74},"obj":"JJ"},{"id":"T22618","span":{"begin":62,"end":64},"obj":"VB"},{"id":"T22617","span":{"begin":57,"end":61},"obj":"RB"},{"id":"T22616","span":{"begin":53,"end":56},"obj":"MD"},{"id":"T22615","span":{"begin":41,"end":52},"obj":"NN"},{"id":"T22614","span":{"begin":34,"end":40},"obj":"IN"},{"id":"T22613","span":{"begin":29,"end":33},"obj":"NN"},{"id":"T22612","span":{"begin":26,"end":28},"obj":"IN"},{"id":"T22611","span":{"begin":15,"end":25},"obj":"NN"},{"id":"T22610","span":{"begin":5,"end":14},"obj":"VB"},{"id":"T22609","span":{"begin":0,"end":4},"obj":"DT"}],"relations":[{"id":"R15317","pred":"arg1Of","subj":"T22651","obj":"T22650"},{"id":"R15274","pred":"arg1Of","subj":"T22611","obj":"T22609"},{"id":"R15275","pred":"arg2Of","subj":"T22611","obj":"T22610"},{"id":"R15276","pred":"arg1Of","subj":"T22611","obj":"T22612"},{"id":"R15277","pred":"arg1Of","subj":"T22611","obj":"T22614"},{"id":"R15278","pred":"arg1Of","subj":"T22611","obj":"T22616"},{"id":"R15279","pred":"arg1Of","subj":"T22611","obj":"T22618"},{"id":"R15280","pred":"arg1Of","subj":"T22611","obj":"T22619"},{"id":"R15281","pred":"arg2Of","subj":"T22613","obj":"T22612"},{"id":"R15282","pred":"arg2Of","subj":"T22615","obj":"T22614"},{"id":"R15283","pred":"arg2Of","subj":"T22618","obj":"T22616"},{"id":"R15284","pred":"arg1Of","subj":"T22618","obj":"T22617"},{"id":"R15285","pred":"arg2Of","subj":"T22619","obj":"T22618"},{"id":"R15286","pred":"arg1Of","subj":"T22619","obj":"T22620"},{"id":"R15287","pred":"arg2Of","subj":"T22623","obj":"T22620"},{"id":"R15288","pred":"arg1Of","subj":"T22623","obj":"T22621"},{"id":"R15289","pred":"arg1Of","subj":"T22623","obj":"T22622"},{"id":"R15290","pred":"arg1Of","subj":"T22623","obj":"T22624"},{"id":"R15291","pred":"arg1Of","subj":"T22623","obj":"T22626"},{"id":"R15292","pred":"arg1Of","subj":"T22623","obj":"T22633"},{"id":"R15293","pred":"arg1Of","subj":"T22623","obj":"T22634"},{"id":"R15294","pred":"arg1Of","subj":"T22626","obj":"T22625"},{"id":"R15295","pred":"arg2Of","subj":"T22627","obj":"T22626"},{"id":"R15296","pred":"arg1Of","subj":"T22628","obj":"T22629"},{"id":"R15297","pred":"arg2Of","subj":"T22629","obj":"T22627"},{"id":"R15298","pred":"arg2Of","subj":"T22632","obj":"T22629"},{"id":"R15299","pred":"arg1Of","subj":"T22632","obj":"T22630"},{"id":"R15300","pred":"arg1Of","subj":"T22632","obj":"T22631"},{"id":"R15301","pred":"arg1Of","subj":"T22636","obj":"T22635"},{"id":"R15302","pred":"arg1Of","subj":"T22636","obj":"T22637"},{"id":"R15303","pred":"arg1Of","subj":"T22636","obj":"T22641"},{"id":"R15304","pred":"arg2Of","subj":"T22640","obj":"T22637"},{"id":"R15305","pred":"arg1Of","subj":"T22640","obj":"T22638"},{"id":"R15306","pred":"arg1Of","subj":"T22640","obj":"T22639"},{"id":"R15307","pred":"arg2Of","subj":"T22641","obj":"T22634"},{"id":"R15308","pred":"arg2Of","subj":"T22644","obj":"T22641"},{"id":"R15309","pred":"arg1Of","subj":"T22644","obj":"T22642"},{"id":"R15310","pred":"arg1Of","subj":"T22644","obj":"T22643"},{"id":"R15311","pred":"arg1Of","subj":"T22644","obj":"T22645"},{"id":"R15312","pred":"arg1Of","subj":"T22648","obj":"T22646"},{"id":"R15313","pred":"arg1Of","subj":"T22648","obj":"T22647"},{"id":"R15314","pred":"arg1Of","subj":"T22648","obj":"T22649"},{"id":"R15315","pred":"arg2Of","subj":"T22649","obj":"T22645"},{"id":"R15316","pred":"arg2Of","subj":"T22651","obj":"T22649"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T21088","span":{"begin":29,"end":33},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T22946","span":{"begin":29,"end":33},"obj":"http://www.uniprot.org/uniprot/P01375"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"UBERON-AE","denotations":[{"id":"T20933","span":{"begin":269,"end":274},"obj":"http://purl.obolibrary.org/obo/UBERON_0000062"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"GO-BP","denotations":[{"id":"T21258","span":{"begin":190,"end":202},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T21254","span":{"begin":216,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0097300"},{"id":"T21240","span":{"begin":216,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0010939"},{"id":"T21227","span":{"begin":216,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T21195","span":{"begin":295,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T21194","span":{"begin":230,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T21155","span":{"begin":41,"end":52},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T21135","span":{"begin":216,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0070266"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"GO-CC","denotations":[{"id":"T21287","span":{"begin":225,"end":229},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"sentences","denotations":[{"id":"T20980","span":{"begin":0,"end":301},"obj":"Sentence"},{"id":"T305","span":{"begin":0,"end":301},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"ICD10","denotations":[{"id":"T21266","span":{"begin":150,"end":170},"obj":"http://purl.bioontology.org/ontology/ICD10/A49.9"},{"id":"T21265","span":{"begin":127,"end":149},"obj":"http://purl.bioontology.org/ontology/ICD10/K85"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"simple1","denotations":[{"id":"T21340","span":{"begin":29,"end":33},"obj":"Protein"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T22814","span":{"begin":5,"end":14},"obj":"Positive_regulation"},{"id":"T22813","span":{"begin":15,"end":25},"obj":"Gene_expression"},{"id":"T22787","span":{"begin":29,"end":33},"obj":"Protein"}],"relations":[{"id":"R15397","pred":"themeOf","subj":"T22787","obj":"T22813"},{"id":"R15405","pred":"themeOf","subj":"T22813","obj":"T22814"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T23118","span":{"begin":29,"end":33},"obj":"Protein"},{"id":"T23144","span":{"begin":5,"end":14},"obj":"Positive_regulation"},{"id":"T23143","span":{"begin":15,"end":25},"obj":"Gene_expression"}],"relations":[{"id":"R15472","pred":"themeOf","subj":"T23118","obj":"T23143"},{"id":"R15480","pred":"themeOf","subj":"T23143","obj":"T23144"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"DLUT931","denotations":[{"id":"T23023","span":{"begin":5,"end":14},"obj":"Positive_regulation"},{"id":"T23022","span":{"begin":15,"end":25},"obj":"Gene_expression"},{"id":"T22988","span":{"begin":29,"end":33},"obj":"Protein"}],"relations":[{"id":"R15430","pred":"themeOf","subj":"T22988","obj":"T23022"},{"id":"R15442","pred":"themeOf","subj":"T23022","obj":"T23023"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T23477","span":{"begin":26,"end":33},"obj":"Protein"},{"id":"T23654","span":{"begin":0,"end":52},"obj":"Gene_expression"},{"id":"T23627","span":{"begin":0,"end":52},"obj":"Positive_regulation"}],"relations":[{"id":"R15644","pred":"themeOf","subj":"T23477","obj":"T23654"},{"id":"R15683","pred":"themeOf","subj":"T23654","obj":"T23627"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T24968","span":{"begin":15,"end":25},"obj":"NN"},{"id":"T24967","span":{"begin":5,"end":14},"obj":"VBD"},{"id":"T24966","span":{"begin":0,"end":4},"obj":"DT"},{"id":"T25009","span":{"begin":300,"end":301},"obj":"."},{"id":"T25008","span":{"begin":295,"end":300},"obj":"NN"},{"id":"T25007","span":{"begin":287,"end":294},"obj":"NN"},{"id":"T25006","span":{"begin":283,"end":286},"obj":"CC"},{"id":"T25005","span":{"begin":275,"end":282},"obj":"NN"},{"id":"T25004","span":{"begin":269,"end":274},"obj":"NN"},{"id":"T25003","span":{"begin":260,"end":268},"obj":"JJ"},{"id":"T25002","span":{"begin":257,"end":259},"obj":"IN"},{"id":"T25001","span":{"begin":251,"end":256},"obj":"NN"},{"id":"T25000","span":{"begin":243,"end":250},"obj":"JJ"},{"id":"T24999","span":{"begin":239,"end":242},"obj":"DT"},{"id":"T24998","span":{"begin":236,"end":238},"obj":"VBZ"},{"id":"T24997","span":{"begin":230,"end":235},"obj":"NN"},{"id":"T24996","span":{"begin":225,"end":229},"obj":"NN"},{"id":"T24995","span":{"begin":216,"end":224},"obj":"JJ"},{"id":"T24994","span":{"begin":203,"end":215},"obj":"VBG"},{"id":"T24993","span":{"begin":190,"end":202},"obj":"NN"},{"id":"T24992","span":{"begin":178,"end":189},"obj":"JJ"},{"id":"T24991","span":{"begin":172,"end":177},"obj":"WRB"},{"id":"T24990","span":{"begin":170,"end":171},"obj":","},{"id":"T24989","span":{"begin":160,"end":170},"obj":"NNS"},{"id":"T24988","span":{"begin":150,"end":159},"obj":"JJ"},{"id":"T24987","span":{"begin":144,"end":149},"obj":"JJ"},{"id":"T24986","span":{"begin":140,"end":143},"obj":"CC"},{"id":"T24985","span":{"begin":127,"end":139},"obj":"NN"},{"id":"T24984","span":{"begin":115,"end":126},"obj":"VBG"},{"id":"T24983","span":{"begin":112,"end":114},"obj":"IN"},{"id":"T24982","span":{"begin":107,"end":111},"obj":"JJ"},{"id":"T24981","span":{"begin":105,"end":106},"obj":","},{"id":"T24980","span":{"begin":97,"end":105},"obj":"NNS"},{"id":"T24979","span":{"begin":85,"end":96},"obj":"JJ"},{"id":"T24978","span":{"begin":79,"end":84},"obj":"JJ"},{"id":"T24977","span":{"begin":75,"end":78},"obj":"IN"},{"id":"T24976","span":{"begin":65,"end":74},"obj":"JJ"},{"id":"T24975","span":{"begin":62,"end":64},"obj":"VB"},{"id":"T24974","span":{"begin":57,"end":61},"obj":"RB"},{"id":"T24973","span":{"begin":53,"end":56},"obj":"MD"},{"id":"T24972","span":{"begin":41,"end":52},"obj":"NN"},{"id":"T24971","span":{"begin":34,"end":40},"obj":"IN"},{"id":"T24970","span":{"begin":29,"end":33},"obj":"NNP"},{"id":"T24969","span":{"begin":26,"end":28},"obj":"IN"}],"relations":[{"id":"R17048","pred":"nsubj","subj":"T24966","obj":"T24967"},{"id":"R17049","pred":"amod","subj":"T24967","obj":"T24968"},{"id":"R17050","pred":"nsubj","subj":"T24968","obj":"T24975"},{"id":"R17051","pred":"prep","subj":"T24969","obj":"T24968"},{"id":"R17052","pred":"pobj","subj":"T24970","obj":"T24969"},{"id":"R17053","pred":"prep","subj":"T24971","obj":"T24968"},{"id":"R17054","pred":"pobj","subj":"T24972","obj":"T24971"},{"id":"R17055","pred":"aux","subj":"T24973","obj":"T24975"},{"id":"R17056","pred":"advmod","subj":"T24974","obj":"T24975"},{"id":"R17057","pred":"ROOT","subj":"T24975","obj":"T24975"},{"id":"R17058","pred":"acomp","subj":"T24976","obj":"T24975"},{"id":"R17059","pred":"prep","subj":"T24977","obj":"T24976"},{"id":"R17060","pred":"amod","subj":"T24978","obj":"T24980"},{"id":"R17061","pred":"amod","subj":"T24979","obj":"T24980"},{"id":"R17062","pred":"pobj","subj":"T24980","obj":"T24977"},{"id":"R17063","pred":"punct","subj":"T24981","obj":"T24980"},{"id":"R17064","pred":"amod","subj":"T24982","obj":"T24983"},{"id":"R17065","pred":"prep","subj":"T24983","obj":"T24980"},{"id":"R17066","pred":"pcomp","subj":"T24984","obj":"T24983"},{"id":"R17067","pred":"dobj","subj":"T24985","obj":"T24984"},{"id":"R17068","pred":"cc","subj":"T24986","obj":"T24985"},{"id":"R17069","pred":"amod","subj":"T24987","obj":"T24989"},{"id":"R17070","pred":"amod","subj":"T24988","obj":"T24989"},{"id":"R17071","pred":"conj","subj":"T24989","obj":"T24985"},{"id":"R17072","pred":"punct","subj":"T24990","obj":"T24989"},{"id":"R17073","pred":"advmod","subj":"T24991","obj":"T24998"},{"id":"R17074","pred":"amod","subj":"T24992","obj":"T24993"},{"id":"R17075","pred":"poss","subj":"T24993","obj":"T24997"},{"id":"R17076","pred":"amod","subj":"T24994","obj":"T24997"},{"id":"R17077","pred":"amod","subj":"T24995","obj":"T24997"},{"id":"R17078","pred":"compound","subj":"T24996","obj":"T24997"},{"id":"R17079","pred":"nsubj","subj":"T24997","obj":"T24998"},{"id":"R17080","pred":"advcl","subj":"T24998","obj":"T24975"},{"id":"R17081","pred":"det","subj":"T24999","obj":"T25001"},{"id":"R17082","pred":"amod","subj":"T25000","obj":"T25001"},{"id":"R17083","pred":"attr","subj":"T25001","obj":"T24998"},{"id":"R17084","pred":"prep","subj":"T25002","obj":"T25001"},{"id":"R17085","pred":"amod","subj":"T25003","obj":"T25005"},{"id":"R17086","pred":"compound","subj":"T25004","obj":"T25005"},{"id":"R17087","pred":"pobj","subj":"T25005","obj":"T25002"},{"id":"R17088","pred":"cc","subj":"T25006","obj":"T25005"},{"id":"R17089","pred":"compound","subj":"T25007","obj":"T25008"},{"id":"R17090","pred":"conj","subj":"T25008","obj":"T25005"},{"id":"R17091","pred":"punct","subj":"T25009","obj":"T24975"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T23303","span":{"begin":5,"end":14},"obj":"Positive_regulation"},{"id":"T23302","span":{"begin":15,"end":25},"obj":"Gene_expression"},{"id":"T23301","span":{"begin":29,"end":33},"obj":"Protein"}],"relations":[{"id":"R15559","pred":"themeOf","subj":"T23301","obj":"T23302"},{"id":"R15560","pred":"themeOf","subj":"T23302","obj":"T23303"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}

{"project":"test3","denotations":[{"id":"T20925","span":{"begin":29,"end":33},"obj":"Protein"},{"id":"T20924","span":{"begin":15,"end":25},"obj":"Gene_expression"},{"id":"T20923","span":{"begin":5,"end":14},"obj":"Positive_regulation"},{"id":"T20843","span":{"begin":29,"end":33},"obj":"Protein"}],"relations":[{"id":"R13957","pred":"themeOf","subj":"T20924","obj":"T20923"},{"id":"R13958","pred":"themeOf","subj":"T20925","obj":"T20924"}],"text":"This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death."}