PMC:3585731 / 48348-48722
Annnotations
testone
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T20802 | 344-353 | Gene_expression | denotes | synthesis |
T20801 | 325-335 | Positive_regulation | denotes | activation |
T20755 | 357-361 | Protein | denotes | RIP1 |
T20754 | 339-343 | Protein | denotes | TNFα |
R13922 | T20754 | T20802 | themeOf | TNFα,synthesis |
R13933 | T20802 | T20801 | themeOf | synthesis,activation |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22526 | 366-373 | NN | denotes | kinases |
T22525 | 357-365 | NN | denotes | RIP1/Akt |
T22524 | 354-356 | IN | denotes | by |
T22523 | 344-353 | NN | denotes | synthesis |
T22522 | 339-343 | NN | denotes | TNFα |
T22521 | 336-338 | IN | denotes | of |
T22520 | 325-335 | NN | denotes | activation |
T22519 | 316-324 | JJ | denotes | specific |
T22518 | 312-315 | DT | denotes | the |
T22517 | 309-311 | TO | denotes | to |
T22516 | 305-308 | JJ | denotes | due |
T22515 | 293-304 | NN | denotes | necroptosis |
T22514 | 290-292 | IN | denotes | of |
T22513 | 280-289 | NN | denotes | component |
T22512 | 270-279 | VB | denotes | regulated |
T22511 | 266-269 | CC | denotes | and |
T22510 | 256-265 | JJ | denotes | intrinsic |
T22509 | 253-255 | DT | denotes | an |
T22508 | 250-252 | VB | denotes | is |
T22507 | 247-249 | PRP | denotes | it |
T22506 | 242-246 | IN | denotes | that |
T22505 | 237-241 | RB | denotes | also |
T22504 | 233-236 | CC | denotes | but |
T22503 | 231-232 | -COMMA- | denotes | , |
T22502 | 226-231 | NN | denotes | death |
T22501 | 221-225 | NN | denotes | cell |
T22500 | 212-220 | JJ | denotes | necrotic |
T22499 | 208-211 | IN | denotes | for |
T22498 | 193-207 | JJ | denotes | characteristic |
T22497 | 183-192 | NN | denotes | integrity |
T22496 | 174-182 | NN | denotes | membrane |
T22495 | 167-173 | NN | denotes | plasma |
T22494 | 164-166 | IN | denotes | of |
T22493 | 159-163 | NN | denotes | loss |
T22492 | 153-158 | JJ | denotes | rapid |
T22491 | 150-152 | IN | denotes | of |
T22490 | 143-149 | NN | denotes | virtue |
T22489 | 139-142 | DT | denotes | the |
T22488 | 136-138 | IN | denotes | by |
T22487 | 128-135 | NN | denotes | systems |
T22486 | 119-127 | JJ | denotes | cellular |
T22485 | 116-118 | IN | denotes | of |
T22484 | 108-115 | NN | denotes | variety |
T22483 | 106-107 | DT | denotes | a |
T22482 | 103-105 | IN | denotes | in |
T22481 | 91-102 | NN | denotes | necroptosis |
T22480 | 79-90 | VB | denotes | accompanies |
T22479 | 69-78 | RB | denotes | passively |
T22478 | 64-68 | RB | denotes | only |
T22477 | 60-63 | RB | denotes | not |
T22476 | 47-59 | NN | denotes | inflammation |
T22475 | 42-46 | IN | denotes | that |
T22474 | 35-41 | NN | denotes | notion |
T22473 | 25-34 | JJ | denotes | important |
T22472 | 22-24 | DT | denotes | an |
T22471 | 12-21 | VB | denotes | highlight |
T22470 | 4-11 | NN | denotes | results |
T22469 | 0-3 | PRP-DOLLAR- | denotes | Our |
R15132 | T22470 | T22469 | arg1Of | results,Our |
R15133 | T22470 | T22471 | arg1Of | results,highlight |
R15134 | T22474 | T22471 | arg2Of | notion,highlight |
R15135 | T22474 | T22472 | arg1Of | notion,an |
R15136 | T22474 | T22473 | arg1Of | notion,important |
R15137 | T22476 | T22480 | arg1Of | inflammation,accompanies |
R15138 | T22478 | T22477 | arg1Of | only,not |
R15139 | T22480 | T22474 | arg2Of | accompanies,notion |
R15140 | T22480 | T22475 | arg1Of | accompanies,that |
R15141 | T22480 | T22478 | arg1Of | accompanies,only |
R15142 | T22480 | T22479 | arg1Of | accompanies,passively |
R15143 | T22480 | T22482 | arg1Of | accompanies,in |
R15144 | T22480 | T22488 | arg1Of | accompanies,by |
R15145 | T22481 | T22480 | arg2Of | necroptosis,accompanies |
R15146 | T22484 | T22482 | arg2Of | variety,in |
R15147 | T22484 | T22483 | arg1Of | variety,a |
R15148 | T22484 | T22485 | arg1Of | variety,of |
R15149 | T22487 | T22485 | arg2Of | systems,of |
R15150 | T22487 | T22486 | arg1Of | systems,cellular |
R15151 | T22490 | T22488 | arg2Of | virtue,by |
R15152 | T22490 | T22489 | arg1Of | virtue,the |
R15153 | T22490 | T22491 | arg1Of | virtue,of |
R15154 | T22493 | T22491 | arg2Of | loss,of |
R15155 | T22493 | T22492 | arg1Of | loss,rapid |
R15156 | T22493 | T22494 | arg1Of | loss,of |
R15157 | T22493 | T22506 | arg1Of | loss,that |
R15158 | T22493 | T22514 | arg1Of | loss,of |
R15159 | T22494 | T22504 | arg1Of | of,but |
R15160 | T22497 | T22494 | arg2Of | integrity,of |
R15161 | T22497 | T22495 | arg1Of | integrity,plasma |
R15162 | T22497 | T22496 | arg1Of | integrity,membrane |
R15163 | T22497 | T22498 | arg1Of | integrity,characteristic |
R15164 | T22498 | T22499 | arg1Of | characteristic,for |
R15165 | T22502 | T22499 | arg2Of | death,for |
R15166 | T22502 | T22500 | arg1Of | death,necrotic |
R15167 | T22502 | T22501 | arg1Of | death,cell |
R15168 | T22504 | T22503 | arg1Of | but,"," |
R15169 | T22504 | T22505 | arg1Of | but,also |
R15170 | T22506 | T22504 | arg2Of | that,but |
R15171 | T22507 | T22508 | arg1Of | it,is |
R15172 | T22508 | T22506 | arg2Of | is,that |
R15173 | T22510 | T22511 | arg1Of | intrinsic,and |
R15174 | T22512 | T22511 | arg2Of | regulated,and |
R15175 | T22513 | T22508 | arg2Of | component,is |
R15176 | T22513 | T22509 | arg1Of | component,an |
R15177 | T22513 | T22510 | arg1Of | component,intrinsic |
R15178 | T22513 | T22512 | arg1Of | component,regulated |
R15179 | T22515 | T22514 | arg2Of | necroptosis,of |
R15180 | T22515 | T22517 | arg1Of | necroptosis,to |
R15181 | T22517 | T22516 | arg1Of | to,due |
R15182 | T22520 | T22517 | arg2Of | activation,to |
R15183 | T22520 | T22518 | arg1Of | activation,the |
R15184 | T22520 | T22519 | arg1Of | activation,specific |
R15185 | T22520 | T22521 | arg1Of | activation,of |
R15186 | T22520 | T22524 | arg1Of | activation,by |
R15187 | T22523 | T22521 | arg2Of | synthesis,of |
R15188 | T22523 | T22522 | arg1Of | synthesis,TNFα |
R15189 | T22526 | T22524 | arg2Of | kinases,by |
R15190 | T22526 | T22525 | arg1Of | kinases,RIP1/Akt |
bionlp-st-ge-2016-test-proteins
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21082 | 357-361 | Protein | denotes | RIP1 |
T21081 | 339-343 | Protein | denotes | TNFα |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22944 | 339-343 | http://www.uniprot.org/uniprot/P01375 | denotes | TNFα |
T22930 | 357-361 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T22917 | 362-365 | http://www.uniprot.org/uniprot/Q9Y243 | denotes | Akt |
T22883 | 362-365 | http://www.uniprot.org/uniprot/P31751 | denotes | Akt |
T22849 | 362-365 | http://www.uniprot.org/uniprot/P31749 | denotes | Akt |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21259 | 119-127 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T21256 | 47-59 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T21253 | 212-231 | http://purl.obolibrary.org/obo/GO_0097300 | denotes | necrotic cell death |
T21239 | 212-231 | http://purl.obolibrary.org/obo/GO_0010939 | denotes | necrotic cell death |
T21226 | 212-231 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrotic cell death |
T21193 | 226-231 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
T21176 | 221-231 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T21166 | 344-353 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T21153 | 293-304 | http://purl.obolibrary.org/obo/GO_0097528 | denotes | necroptosis |
T21152 | 91-102 | http://purl.obolibrary.org/obo/GO_0097528 | denotes | necroptosis |
T21134 | 212-231 | http://purl.obolibrary.org/obo/GO_0070266 | denotes | necrotic cell death |
T21129 | 293-304 | http://purl.obolibrary.org/obo/GO_0070266 | denotes | necroptosis |
T21128 | 91-102 | http://purl.obolibrary.org/obo/GO_0070266 | denotes | necroptosis |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21292 | 174-182 | http://purl.obolibrary.org/obo/GO_0016020 | denotes | membrane |
T21289 | 167-182 | http://purl.obolibrary.org/obo/GO_0005886 | denotes | plasma membrane |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T20976 | 0-374 | Sentence | denotes | Our results highlight an important notion that inflammation not only passively accompanies necroptosis in a variety of cellular systems by the virtue of rapid loss of plasma membrane integrity characteristic for necrotic cell death, but also that it is an intrinsic and regulated component of necroptosis due to the specific activation of TNFα synthesis by RIP1/Akt kinases. |
T301 | 0-374 | Sentence | denotes | Our results highlight an important notion that inflammation not only passively accompanies necroptosis in a variety of cellular systems by the virtue of rapid loss of plasma membrane integrity characteristic for necrotic cell death, but also that it is an intrinsic and regulated component of necroptosis due to the specific activation of TNFα synthesis by RIP1/Akt kinases. |
simple1
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21334 | 357-361 | Protein | denotes | RIP1 |
T21333 | 339-343 | Protein | denotes | TNFα |
BioNLP16_DUT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22809 | 344-353 | Gene_expression | denotes | synthesis |
T22808 | 325-335 | Positive_regulation | denotes | activation |
T22781 | 357-361 | Protein | denotes | RIP1 |
T22780 | 339-343 | Protein | denotes | TNFα |
R15392 | T22780 | T22809 | themeOf | TNFα,synthesis |
R15404 | T22809 | T22808 | themeOf | synthesis,activation |
BioNLP16_Messiy
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T23112 | 357-361 | Protein | denotes | RIP1 |
T23111 | 339-343 | Protein | denotes | TNFα |
T23140 | 325-335 | Positive_regulation | denotes | activation |
T23139 | 344-353 | Gene_expression | denotes | synthesis |
R15469 | T23111 | T23139 | themeOf | TNFα,synthesis |
R15479 | T23139 | T23140 | themeOf | synthesis,activation |
DLUT931
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T23019 | 325-335 | Positive_regulation | denotes | activation |
T23018 | 344-353 | Gene_expression | denotes | synthesis |
T22982 | 357-361 | Protein | denotes | RIP1 |
T22981 | 339-343 | Protein | denotes | TNFα |
R15441 | T23018 | T23019 | themeOf | synthesis,activation |
R15426 | T22981 | T23018 | themeOf | TNFα,synthesis |
bionlp-st-ge-2016-test-ihmc
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T23574 | 354-373 | Protein | denotes | by RIP1/Akt kinases |
T23570 | 174-182 | Entity | denotes | membrane |
T23554 | 336-353 | Protein | denotes | of TNFα synthesis |
T23484 | 357-365 | Protein | denotes | RIP1/Akt |
T23622 | 357-365 | Protein | denotes | RIP1/Akt |
T23610 | 164-231 | Entity | denotes | of plasma membrane integrity characteristic for necrotic cell death |
T23607 | 362-365 | Protein | denotes | Akt |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T24880 | 373-374 | . | denotes | . |
T24879 | 366-373 | NNS | denotes | kinases |
T24878 | 357-365 | JJ | denotes | RIP1/Akt |
T24877 | 354-356 | IN | denotes | by |
T24876 | 344-353 | NN | denotes | synthesis |
T24875 | 339-343 | NNP | denotes | TNFα |
T24874 | 336-338 | IN | denotes | of |
T24873 | 325-335 | NN | denotes | activation |
T24872 | 316-324 | JJ | denotes | specific |
T24871 | 312-315 | DT | denotes | the |
T24870 | 309-311 | TO | denotes | to |
T24869 | 305-308 | JJ | denotes | due |
T24868 | 293-304 | NN | denotes | necroptosis |
T24867 | 290-292 | IN | denotes | of |
T24866 | 280-289 | NN | denotes | component |
T24865 | 270-279 | JJ | denotes | regulated |
T24864 | 266-269 | CC | denotes | and |
T24863 | 256-265 | JJ | denotes | intrinsic |
T24862 | 253-255 | DT | denotes | an |
T24861 | 250-252 | VBZ | denotes | is |
T24860 | 247-249 | PRP | denotes | it |
T24859 | 242-246 | IN | denotes | that |
T24858 | 237-241 | RB | denotes | also |
T24857 | 233-236 | CC | denotes | but |
T24856 | 231-232 | , | denotes | , |
T24855 | 226-231 | NN | denotes | death |
T24854 | 221-225 | NN | denotes | cell |
T24853 | 212-220 | JJ | denotes | necrotic |
T24852 | 208-211 | IN | denotes | for |
T24851 | 193-207 | NN | denotes | characteristic |
T24850 | 183-192 | NN | denotes | integrity |
T24849 | 174-182 | NN | denotes | membrane |
T24848 | 167-173 | NN | denotes | plasma |
T24847 | 164-166 | IN | denotes | of |
T24846 | 159-163 | NN | denotes | loss |
T24845 | 153-158 | JJ | denotes | rapid |
T24844 | 150-152 | IN | denotes | of |
T24843 | 143-149 | NN | denotes | virtue |
T24842 | 139-142 | DT | denotes | the |
T24841 | 136-138 | IN | denotes | by |
T24840 | 128-135 | NNS | denotes | systems |
T24839 | 119-127 | JJ | denotes | cellular |
T24838 | 116-118 | IN | denotes | of |
T24837 | 108-115 | NN | denotes | variety |
T24836 | 106-107 | DT | denotes | a |
T24835 | 103-105 | IN | denotes | in |
T24834 | 91-102 | NN | denotes | necroptosis |
T24833 | 79-90 | VBZ | denotes | accompanies |
T24832 | 69-78 | RB | denotes | passively |
T24831 | 64-68 | RB | denotes | only |
T24830 | 60-63 | RB | denotes | not |
T24829 | 47-59 | NN | denotes | inflammation |
T24828 | 42-46 | IN | denotes | that |
T24827 | 35-41 | NN | denotes | notion |
T24826 | 25-34 | JJ | denotes | important |
T24825 | 22-24 | DT | denotes | an |
T24824 | 12-21 | VBP | denotes | highlight |
T24823 | 4-11 | NNS | denotes | results |
T24822 | 0-3 | PRP$ | denotes | Our |
R16833 | T24822 | T24823 | poss | Our,results |
R16837 | T24823 | T24824 | nsubj | results,highlight |
R16838 | T24824 | T24824 | ROOT | highlight,highlight |
R16840 | T24825 | T24827 | det | an,notion |
R16841 | T24826 | T24827 | amod | important,notion |
R16843 | T24827 | T24824 | dobj | notion,highlight |
R16844 | T24828 | T24833 | mark | that,accompanies |
R16846 | T24829 | T24833 | nsubj | inflammation,accompanies |
R16847 | T24830 | T24833 | preconj | not,accompanies |
R16848 | T24831 | T24830 | advmod | only,not |
R16850 | T24832 | T24833 | advmod | passively,accompanies |
R16851 | T24833 | T24827 | acl | accompanies,notion |
R16852 | T24834 | T24833 | dobj | necroptosis,accompanies |
R16854 | T24835 | T24833 | prep | in,accompanies |
R16855 | T24836 | T24837 | det | a,variety |
R16857 | T24837 | T24835 | pobj | variety,in |
R16858 | T24838 | T24837 | prep | of,variety |
R16859 | T24839 | T24840 | amod | cellular,systems |
R16861 | T24840 | T24838 | pobj | systems,of |
R16862 | T24841 | T24833 | prep | by,accompanies |
R16863 | T24842 | T24843 | det | the,virtue |
R16865 | T24843 | T24841 | pobj | virtue,by |
R16867 | T24844 | T24843 | prep | of,virtue |
R16870 | T24845 | T24846 | amod | rapid,loss |
R16872 | T24846 | T24844 | pobj | loss,of |
R16874 | T24847 | T24846 | prep | of,loss |
R16876 | T24848 | T24849 | compound | plasma,membrane |
R16878 | T24849 | T24850 | compound | membrane,integrity |
R16879 | T24850 | T24851 | compound | integrity,characteristic |
R16880 | T24851 | T24847 | pobj | characteristic,of |
R16881 | T24852 | T24846 | prep | for,loss |
R16882 | T24853 | T24855 | amod | necrotic,death |
R16883 | T24854 | T24855 | compound | cell,death |
R16885 | T24855 | T24852 | pobj | death,for |
R16886 | T24856 | T24833 | punct | ",",accompanies |
R16887 | T24857 | T24833 | cc | but,accompanies |
R16888 | T24858 | T24857 | advmod | also,but |
R16890 | T24859 | T24861 | mark | that,is |
R16891 | T24860 | T24861 | nsubj | it,is |
R16892 | T24861 | T24833 | conj | is,accompanies |
R16894 | T24862 | T24866 | det | an,component |
R16895 | T24863 | T24866 | amod | intrinsic,component |
R16897 | T24864 | T24863 | cc | and,intrinsic |
R16898 | T24865 | T24863 | conj | regulated,intrinsic |
R16899 | T24866 | T24861 | attr | component,is |
R16900 | T24867 | T24866 | prep | of,component |
R16902 | T24868 | T24867 | pobj | necroptosis,of |
R16903 | T24869 | T24866 | amod | due,component |
R16905 | T24870 | T24869 | pcomp | to,due |
R16906 | T24871 | T24873 | det | the,activation |
R16907 | T24872 | T24873 | amod | specific,activation |
R16909 | T24873 | T24869 | pobj | activation,due |
R16910 | T24874 | T24873 | prep | of,activation |
R16911 | T24875 | T24876 | compound | TNFα,synthesis |
R16913 | T24876 | T24874 | pobj | synthesis,of |
R16914 | T24877 | T24873 | prep | by,activation |
R16915 | T24878 | T24879 | amod | RIP1/Akt,kinases |
R16917 | T24879 | T24877 | pobj | kinases,by |
R16918 | T24880 | T24824 | punct | .,highlight |
bionlp-st-ge-2016-test-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T23291 | 325-335 | Positive_regulation | denotes | activation |
T23290 | 344-353 | Gene_expression | denotes | synthesis |
T23289 | 325-335 | Positive_regulation | denotes | activation |
T23288 | 362-365 | Protein | denotes | Akt |
T23287 | 357-361 | Protein | denotes | RIP1 |
T23286 | 339-343 | Protein | denotes | TNFα |
R15549 | T23286 | T23290 | themeOf | TNFα,synthesis |
R15550 | T23288 | T23289 | themeOf | Akt,activation |
R15551 | T23290 | T23291 | themeOf | synthesis,activation |
test3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T20916 | 357-361 | Protein | denotes | RIP1 |
T20915 | 344-353 | Gene_expression | denotes | synthesis |
T20914 | 339-343 | Protein | denotes | TNFα |
T20913 | 325-335 | Positive_regulation | denotes | activation |
T20837 | 357-361 | Protein | denotes | RIP1 |
T20836 | 339-343 | Protein | denotes | TNFα |
R13954 | T20914 | T20915 | themeOf | TNFα,synthesis |
R13955 | T20915 | T20913 | themeOf | synthesis,activation |