PMC:3585731 / 4319-5278 JSONTXT

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{"project":"GO-BP","denotations":[{"id":"T13928","span":{"begin":260,"end":275},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T1048","span":{"begin":893,"end":911},"obj":"http://purl.obolibrary.org/obo/GO_0097300"},{"id":"T1047","span":{"begin":260,"end":275},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T1035","span":{"begin":539,"end":542},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T1034","span":{"begin":124,"end":127},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T1018","span":{"begin":949,"end":958},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T1017","span":{"begin":361,"end":370},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T1009","span":{"begin":916,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T1008","span":{"begin":903,"end":911},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T1006","span":{"begin":916,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T1005","span":{"begin":903,"end":911},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T1003","span":{"begin":916,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T1002","span":{"begin":903,"end":911},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T1000","span":{"begin":802,"end":807},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T995","span":{"begin":916,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T986","span":{"begin":172,"end":183},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T969","span":{"begin":412,"end":437},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T968","span":{"begin":283,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T967","span":{"begin":172,"end":183},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T994","span":{"begin":903,"end":911},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T988","span":{"begin":426,"end":437},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T987","span":{"begin":283,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0097528"}],"text":"In this study, we expanded these observations to delineate the specific contributions and molecular ordering of the Akt and JNK pathways downstream from RIP1 kinase during necroptosis. Our data reveal that Akt is activated through RIP1 kinase-dependent Thr308 phosphorylation during necroptosis in multiple cell types. Furthermore, we found that downstream Akt signaling through mTORC1 and S6 contributes to the activation of necroptosis and TNFα production. We found that the Akt pathway serves as a critical link between RIP1 kinase and JNK activation in L929 cells. Further data suggested that in multiple other cell types including FADD deficient Jurkat cells, RAW and J774.1 macrophage cell lines, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling."}

{"project":"GO-MF","denotations":[{"id":"T1054","span":{"begin":539,"end":542},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T1053","span":{"begin":124,"end":127},"obj":"http://purl.obolibrary.org/obo/GO_0004705"}],"text":"In this study, we expanded these observations to delineate the specific contributions and molecular ordering of the Akt and JNK pathways downstream from RIP1 kinase during necroptosis. Our data reveal that Akt is activated through RIP1 kinase-dependent Thr308 phosphorylation during necroptosis in multiple cell types. Furthermore, we found that downstream Akt signaling through mTORC1 and S6 contributes to the activation of necroptosis and TNFα production. We found that the Akt pathway serves as a critical link between RIP1 kinase and JNK activation in L929 cells. Further data suggested that in multiple other cell types including FADD deficient Jurkat cells, RAW and J774.1 macrophage cell lines, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling."}

{"project":"GO-CC","denotations":[{"id":"T1065","span":{"begin":379,"end":385},"obj":"http://purl.obolibrary.org/obo/GO_0031931"},{"id":"T1064","span":{"begin":797,"end":801},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1063","span":{"begin":691,"end":695},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1062","span":{"begin":615,"end":619},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1061","span":{"begin":307,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In this study, we expanded these observations to delineate the specific contributions and molecular ordering of the Akt and JNK pathways downstream from RIP1 kinase during necroptosis. Our data reveal that Akt is activated through RIP1 kinase-dependent Thr308 phosphorylation during necroptosis in multiple cell types. Furthermore, we found that downstream Akt signaling through mTORC1 and S6 contributes to the activation of necroptosis and TNFα production. We found that the Akt pathway serves as a critical link between RIP1 kinase and JNK activation in L929 cells. Further data suggested that in multiple other cell types including FADD deficient Jurkat cells, RAW and J774.1 macrophage cell lines, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling."}

{"project":"sentences","denotations":[{"id":"T901","span":{"begin":816,"end":959},"obj":"Sentence"},{"id":"T900","span":{"begin":569,"end":815},"obj":"Sentence"},{"id":"T899","span":{"begin":459,"end":568},"obj":"Sentence"},{"id":"T898","span":{"begin":319,"end":458},"obj":"Sentence"},{"id":"T897","span":{"begin":185,"end":318},"obj":"Sentence"},{"id":"T896","span":{"begin":0,"end":184},"obj":"Sentence"},{"id":"T30","span":{"begin":0,"end":184},"obj":"Sentence"},{"id":"T31","span":{"begin":185,"end":318},"obj":"Sentence"},{"id":"T32","span":{"begin":319,"end":458},"obj":"Sentence"},{"id":"T33","span":{"begin":459,"end":568},"obj":"Sentence"},{"id":"T34","span":{"begin":569,"end":815},"obj":"Sentence"},{"id":"T35","span":{"begin":816,"end":959},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In this study, we expanded these observations to delineate the specific contributions and molecular ordering of the Akt and JNK pathways downstream from RIP1 kinase during necroptosis. Our data reveal that Akt is activated through RIP1 kinase-dependent Thr308 phosphorylation during necroptosis in multiple cell types. Furthermore, we found that downstream Akt signaling through mTORC1 and S6 contributes to the activation of necroptosis and TNFα production. We found that the Akt pathway serves as a critical link between RIP1 kinase and JNK activation in L929 cells. Further data suggested that in multiple other cell types including FADD deficient Jurkat cells, RAW and J774.1 macrophage cell lines, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling."}

{"project":"simple1","denotations":[{"id":"T14032","span":{"begin":231,"end":235},"obj":"Protein"},{"id":"T1084","span":{"begin":757,"end":761},"obj":"Protein"},{"id":"T1083","span":{"begin":636,"end":640},"obj":"Protein"},{"id":"T1082","span":{"begin":523,"end":527},"obj":"Protein"},{"id":"T1081","span":{"begin":442,"end":446},"obj":"Protein"},{"id":"T1080","span":{"begin":390,"end":392},"obj":"Protein"},{"id":"T1079","span":{"begin":231,"end":235},"obj":"Protein"},{"id":"T1078","span":{"begin":153,"end":157},"obj":"Protein"}],"text":"In this study, we expanded these observations to delineate the specific contributions and molecular ordering of the Akt and JNK pathways downstream from RIP1 kinase during necroptosis. Our data reveal that Akt is activated through RIP1 kinase-dependent Thr308 phosphorylation during necroptosis in multiple cell types. Furthermore, we found that downstream Akt signaling through mTORC1 and S6 contributes to the activation of necroptosis and TNFα production. We found that the Akt pathway serves as a critical link between RIP1 kinase and JNK activation in L929 cells. Further data suggested that in multiple other cell types including FADD deficient Jurkat cells, RAW and J774.1 macrophage cell lines, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T14963","span":{"begin":260,"end":275},"obj":"Phosphorylation"},{"id":"T14962","span":{"begin":236,"end":252},"obj":"Positive_regulation"},{"id":"T14928","span":{"begin":231,"end":235},"obj":"Protein"},{"id":"T1774","span":{"begin":236,"end":252},"obj":"Positive_regulation"},{"id":"T1773","span":{"begin":260,"end":275},"obj":"Phosphorylation"},{"id":"T1772","span":{"begin":213,"end":222},"obj":"Positive_regulation"},{"id":"T1768","span":{"begin":757,"end":761},"obj":"Protein"},{"id":"T1767","span":{"begin":636,"end":640},"obj":"Protein"},{"id":"T1766","span":{"begin":523,"end":527},"obj":"Protein"},{"id":"T1765","span":{"begin":442,"end":446},"obj":"Protein"},{"id":"T1764","span":{"begin":390,"end":392},"obj":"Protein"},{"id":"T1763","span":{"begin":231,"end":235},"obj":"Protein"},{"id":"T1762","span":{"begin":153,"end":157},"obj":"Protein"},{"id":"T1777","span":{"begin":762,"end":772},"obj":"Gene_expression"},{"id":"T1776","span":{"begin":412,"end":422},"obj":"Positive_regulation"},{"id":"T1775","span":{"begin":447,"end":457},"obj":"Gene_expression"}],"relations":[{"id":"R9917","pred":"themeOf","subj":"T14928","obj":"T14963"},{"id":"R9941","pred":"themeOf","subj":"T14963","obj":"T14962"},{"id":"R9942","pred":"themeOf","subj":"T14963","obj":"T14962"},{"id":"R1203","pred":"themeOf","subj":"T1763","obj":"T1773"},{"id":"R1204","pred":"themeOf","subj":"T1765","obj":"T1775"},{"id":"R1205","pred":"themeOf","subj":"T1768","obj":"T1777"},{"id":"R1206","pred":"themeOf","subj":"T1773","obj":"T1772"},{"id":"R1207","pred":"themeOf","subj":"T1773","obj":"T1774"},{"id":"R1208","pred":"themeOf","subj":"T1775","obj":"T1776"}],"text":"In this study, we expanded these observations to delineate the specific contributions and molecular ordering of the Akt and JNK pathways downstream from RIP1 kinase during necroptosis. Our data reveal that Akt is activated through RIP1 kinase-dependent Thr308 phosphorylation during necroptosis in multiple cell types. Furthermore, we found that downstream Akt signaling through mTORC1 and S6 contributes to the activation of necroptosis and TNFα production. We found that the Akt pathway serves as a critical link between RIP1 kinase and JNK activation in L929 cells. Further data suggested that in multiple other cell types including FADD deficient Jurkat cells, RAW and J774.1 macrophage cell lines, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T15277","span":{"begin":260,"end":275},"obj":"Phosphorylation"},{"id":"T15275","span":{"begin":236,"end":252},"obj":"Regulation"},{"id":"T15242","span":{"begin":231,"end":235},"obj":"Protein"},{"id":"T2152","span":{"begin":762,"end":772},"obj":"Gene_expression"},{"id":"T2151","span":{"begin":749,"end":753},"obj":"Positive_regulation"},{"id":"T2150","span":{"begin":641,"end":650},"obj":"Negative_regulation"},{"id":"T2149","span":{"begin":447,"end":457},"obj":"Gene_expression"},{"id":"T2148","span":{"begin":412,"end":422},"obj":"Positive_regulation"},{"id":"T2147","span":{"begin":236,"end":252},"obj":"Regulation"},{"id":"T2146","span":{"begin":213,"end":222},"obj":"Positive_regulation"},{"id":"T2145","span":{"begin":260,"end":275},"obj":"Phosphorylation"},{"id":"T2140","span":{"begin":757,"end":761},"obj":"Protein"},{"id":"T2139","span":{"begin":636,"end":640},"obj":"Protein"},{"id":"T2138","span":{"begin":523,"end":527},"obj":"Protein"},{"id":"T2137","span":{"begin":442,"end":446},"obj":"Protein"},{"id":"T2136","span":{"begin":390,"end":392},"obj":"Protein"},{"id":"T2135","span":{"begin":231,"end":235},"obj":"Protein"},{"id":"T2134","span":{"begin":153,"end":157},"obj":"Protein"}],"relations":[{"id":"R1458","pred":"themeOf","subj":"T2137","obj":"T2149"},{"id":"R1461","pred":"themeOf","subj":"T2139","obj":"T2150"},{"id":"R1462","pred":"themeOf","subj":"T2140","obj":"T2152"},{"id":"R1471","pred":"themeOf","subj":"T2152","obj":"T2151"},{"id":"R10015","pred":"themeOf","subj":"T15242","obj":"T15277"},{"id":"R10033","pred":"themeOf","subj":"T15277","obj":"T15275"},{"id":"R10034","pred":"themeOf","subj":"T15277","obj":"T15275"},{"id":"R1456","pred":"themeOf","subj":"T2135","obj":"T2145"},{"id":"R1466","pred":"themeOf","subj":"T2145","obj":"T2146"},{"id":"R1467","pred":"themeOf","subj":"T2145","obj":"T2147"},{"id":"R1469","pred":"themeOf","subj":"T2149","obj":"T2148"}],"text":"In this study, we expanded these observations to delineate the specific contributions and molecular ordering of the Akt and JNK pathways downstream from RIP1 kinase during necroptosis. Our data reveal that Akt is activated through RIP1 kinase-dependent Thr308 phosphorylation during necroptosis in multiple cell types. Furthermore, we found that downstream Akt signaling through mTORC1 and S6 contributes to the activation of necroptosis and TNFα production. We found that the Akt pathway serves as a critical link between RIP1 kinase and JNK activation in L929 cells. Further data suggested that in multiple other cell types including FADD deficient Jurkat cells, RAW and J774.1 macrophage cell lines, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling."}

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