PMC:3585731 / 360-1133 JSONTXT

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{"project":"GO-MF","denotations":[{"id":"T135","span":{"begin":146,"end":161},"obj":"http://purl.obolibrary.org/obo/GO_0016301"},{"id":"T136","span":{"begin":621,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0004705"}],"text":"k, we investigated the signaling mechanisms controlled by the necroptosis mediator receptor interacting protein-1 (RIP1) kinase. We show that Akt kinase activity is critical for necroptosis in L929 cells and plays a key role in TNFα production. During necroptosis, Akt is activated in a RIP1 dependent fashion through its phosphorylation on Thr308. In L929 cells, this activation requires independent signaling inputs from both growth factors and RIP1. Akt controls necroptosis through downstream targeting of mammalian Target of Rapamycin complex 1 (mTORC1). Akt activity, mediated in part through mTORC1, links RIP1 to JNK activation and autocrine production of TNFα. In other cell types, such as mouse lung fibroblasts and macrophages, Akt exhibited control over necropt"}

{"project":"GO-CC","denotations":[{"id":"T142","span":{"begin":599,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0031931"},{"id":"T141","span":{"begin":551,"end":557},"obj":"http://purl.obolibrary.org/obo/GO_0031931"},{"id":"T138","span":{"begin":679,"end":683},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"k, we investigated the signaling mechanisms controlled by the necroptosis mediator receptor interacting protein-1 (RIP1) kinase. We show that Akt kinase activity is critical for necroptosis in L929 cells and plays a key role in TNFα production. During necroptosis, Akt is activated in a RIP1 dependent fashion through its phosphorylation on Thr308. In L929 cells, this activation requires independent signaling inputs from both growth factors and RIP1. Akt controls necroptosis through downstream targeting of mammalian Target of Rapamycin complex 1 (mTORC1). Akt activity, mediated in part through mTORC1, links RIP1 to JNK activation and autocrine production of TNFα. In other cell types, such as mouse lung fibroblasts and macrophages, Akt exhibited control over necropt"}

{"project":"sentences","denotations":[{"id":"T63","span":{"begin":129,"end":244},"obj":"Sentence"},{"id":"T64","span":{"begin":245,"end":348},"obj":"Sentence"},{"id":"T65","span":{"begin":349,"end":452},"obj":"Sentence"},{"id":"T66","span":{"begin":453,"end":559},"obj":"Sentence"},{"id":"T67","span":{"begin":560,"end":669},"obj":"Sentence"},{"id":"T6","span":{"begin":129,"end":244},"obj":"Sentence"},{"id":"T7","span":{"begin":245,"end":348},"obj":"Sentence"},{"id":"T8","span":{"begin":349,"end":452},"obj":"Sentence"},{"id":"T9","span":{"begin":453,"end":559},"obj":"Sentence"},{"id":"T10","span":{"begin":560,"end":669},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"k, we investigated the signaling mechanisms controlled by the necroptosis mediator receptor interacting protein-1 (RIP1) kinase. We show that Akt kinase activity is critical for necroptosis in L929 cells and plays a key role in TNFα production. During necroptosis, Akt is activated in a RIP1 dependent fashion through its phosphorylation on Thr308. In L929 cells, this activation requires independent signaling inputs from both growth factors and RIP1. Akt controls necroptosis through downstream targeting of mammalian Target of Rapamycin complex 1 (mTORC1). Akt activity, mediated in part through mTORC1, links RIP1 to JNK activation and autocrine production of TNFα. In other cell types, such as mouse lung fibroblasts and macrophages, Akt exhibited control over necropt"}

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{"project":"BioNLP16_Messiy","denotations":[{"id":"T443","span":{"begin":83,"end":113},"obj":"Protein"},{"id":"T444","span":{"begin":115,"end":119},"obj":"Protein"},{"id":"T445","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T446","span":{"begin":287,"end":291},"obj":"Protein"},{"id":"T447","span":{"begin":447,"end":451},"obj":"Protein"},{"id":"T448","span":{"begin":613,"end":617},"obj":"Protein"},{"id":"T449","span":{"begin":664,"end":668},"obj":"Protein"},{"id":"T454","span":{"begin":233,"end":243},"obj":"Gene_expression"}],"relations":[{"id":"R471","pred":"themeOf","subj":"T445","obj":"T454"}],"text":"k, we investigated the signaling mechanisms controlled by the necroptosis mediator receptor interacting protein-1 (RIP1) kinase. We show that Akt kinase activity is critical for necroptosis in L929 cells and plays a key role in TNFα production. During necroptosis, Akt is activated in a RIP1 dependent fashion through its phosphorylation on Thr308. In L929 cells, this activation requires independent signaling inputs from both growth factors and RIP1. Akt controls necroptosis through downstream targeting of mammalian Target of Rapamycin complex 1 (mTORC1). Akt activity, mediated in part through mTORC1, links RIP1 to JNK activation and autocrine production of TNFα. In other cell types, such as mouse lung fibroblasts and macrophages, Akt exhibited control over necropt"}

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We show that Akt kinase activity is critical for necroptosis in L929 cells and plays a key role in TNFα production. During necroptosis, Akt is activated in a RIP1 dependent fashion through its phosphorylation on Thr308. In L929 cells, this activation requires independent signaling inputs from both growth factors and RIP1. Akt controls necroptosis through downstream targeting of mammalian Target of Rapamycin complex 1 (mTORC1). Akt activity, mediated in part through mTORC1, links RIP1 to JNK activation and autocrine production of TNFα. In other cell types, such as mouse lung fibroblasts and macrophages, Akt exhibited control over necropt"}

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{"project":"test3","denotations":[{"id":"T55","span":{"begin":664,"end":668},"obj":"Protein"},{"id":"T54","span":{"begin":650,"end":660},"obj":"Gene_expression"},{"id":"T53","span":{"begin":613,"end":617},"obj":"Protein"},{"id":"T52","span":{"begin":447,"end":451},"obj":"Protein"},{"id":"T51","span":{"begin":322,"end":337},"obj":"Phosphorylation"},{"id":"T50","span":{"begin":287,"end":291},"obj":"Protein"},{"id":"T49","span":{"begin":272,"end":281},"obj":"Positive_regulation"},{"id":"T48","span":{"begin":233,"end":243},"obj":"Gene_expression"},{"id":"T47","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T46","span":{"begin":220,"end":224},"obj":"Regulation"},{"id":"T45","span":{"begin":115,"end":119},"obj":"Protein"},{"id":"T44","span":{"begin":83,"end":113},"obj":"Protein"},{"id":"T43","span":{"begin":44,"end":54},"obj":"Regulation"},{"id":"T37","span":{"begin":664,"end":668},"obj":"Protein"},{"id":"T36","span":{"begin":613,"end":617},"obj":"Protein"},{"id":"T35","span":{"begin":447,"end":451},"obj":"Protein"},{"id":"T34","span":{"begin":287,"end":291},"obj":"Protein"},{"id":"T33","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T32","span":{"begin":115,"end":119},"obj":"Protein"},{"id":"T31","span":{"begin":83,"end":113},"obj":"Protein"}],"relations":[{"id":"R8","pred":"causeOf","subj":"T44","obj":"T43"},{"id":"R9","pred":"equivalentTo","subj":"T45","obj":"T44"},{"id":"R10","pred":"themeOf","subj":"T47","obj":"T48"},{"id":"R11","pred":"themeOf","subj":"T48","obj":"T46"},{"id":"R12","pred":"themeOf","subj":"T50","obj":"T49"},{"id":"R13","pred":"themeOf","subj":"T55","obj":"T54"}],"text":"k, we investigated the signaling mechanisms controlled by the necroptosis mediator receptor interacting protein-1 (RIP1) kinase. We show that Akt kinase activity is critical for necroptosis in L929 cells and plays a key role in TNFα production. During necroptosis, Akt is activated in a RIP1 dependent fashion through its phosphorylation on Thr308. In L929 cells, this activation requires independent signaling inputs from both growth factors and RIP1. Akt controls necroptosis through downstream targeting of mammalian Target of Rapamycin complex 1 (mTORC1). Akt activity, mediated in part through mTORC1, links RIP1 to JNK activation and autocrine production of TNFα. In other cell types, such as mouse lung fibroblasts and macrophages, Akt exhibited control over necropt"}