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PMC:3585731 / 27738-34067 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T31168 2756-2766 Gene_expression denotes expressing
T31167 1892-1902 Gene_expression denotes expression
T31166 2961-2965 Protein denotes TNFα
T31165 2730-2733 Protein denotes 18S
T31164 2659-2663 Protein denotes TNFα
T13521 3248-3257 Positive_regulation denotes increased
T13520 3184-3199 Phosphorylation denotes Phosphorylation
T13519 3117-3126 Positive_regulation denotes increased
T13516 1815-1822 Regulation denotes changes
T13515 1798-1806 Positive_regulation denotes required
T13514 1689-1699 Positive_regulation denotes activation
T13513 1676-1684 Regulation denotes regulate
T13512 1586-1596 Positive_regulation denotes activation
T13511 1573-1581 Negative_regulation denotes uncouple
T13510 1559-1569 Positive_regulation denotes sufficient
T13509 1328-1340 Positive_regulation denotes upregulation
T13508 1298-1313 Phosphorylation denotes phosphorylation
T13507 1270-1280 Positive_regulation denotes activation
T13506 1177-1192 Phosphorylation denotes phosphorylation
T13505 1154-1162 Positive_regulation denotes increase
T13504 1034-1041 Positive_regulation denotes induced
T13503 678-688 Gene_expression denotes expressing
T13502 569-575 Entity denotes domain
T13501 534-542 Negative_regulation denotes deletion
T13500 487-499 Localization denotes localization
T13499 305-315 Positive_regulation denotes activation
T13498 115-125 Gene_expression denotes expressing
T13497 0-10 Gene_expression denotes Expression
T13496 6274-6278 Protein denotes TNFα
T13495 6028-6034 Protein denotes p70S6K
T13494 6018-6022 Protein denotes MDM2
T13493 6011-6016 Protein denotes Foxo4
T13492 6004-6009 Protein denotes FoxO1
T13491 5952-5959 Protein denotes Myr-Akt
T13490 5845-5850 Protein denotes T308D
T13489 5601-5606 Protein denotes T308D
T13488 5571-5575 Protein denotes TNFα
T13487 5560-5565 Protein denotes c-Jun
T13486 5395-5399 Protein denotes PDK1
T13485 5225-5230 Protein denotes S473A
T13484 5158-5163 Protein denotes S473A
T13483 5033-5045 Protein denotes S473D mutant
T13482 4577-4580 Protein denotes Akt
T13481 3969-3976 Protein denotes Myr-Akt
T13480 3915-3919 Protein denotes TNFα
T13479 3782-3789 Protein denotes Myr-Akt
T13478 3666-3670 Protein denotes MDM2
T13477 3656-3661 Protein denotes FoxO1
T13476 3552-3557 Protein denotes FoxO4
T13475 3538-3540 Protein denotes S6
T13474 3530-3536 Protein denotes p70S6K
T13473 3494-3501 Protein denotes Myr-Akt
T13472 3302-3307 Protein denotes K179M
T13471 3281-3288 Protein denotes Myr-Akt
T13470 3127-3134 Protein denotes Myr-Akt
T13469 3090-3097 Protein denotes Myr-Akt
T13467 1755-1759 Protein denotes RIP1
T13466 1646-1650 Protein denotes RIP1
T13465 1344-1348 Protein denotes TNFα
T13464 1292-1297 Protein denotes c-Jun
T13463 1088-1095 Protein denotes Myr-Akt
T13462 996-1001 Protein denotes K179M
T13461 975-982 Protein denotes Myr-Akt
T13460 689-696 Protein denotes Myr-Akt
T13459 364-371 Protein denotes Myr-Akt
T13458 358-362 Protein denotes Akt1
T13457 286-290 Protein denotes RIP1
T13456 210-215 Protein denotes K179M
T13455 164-171 Protein denotes Myr-Akt
T13454 158-162 Protein denotes Akt1
T13551 6266-6273 Positive_regulation denotes promote
T13550 6205-6213 Positive_regulation denotes allowing
T13549 5930-5944 Phosphorylation denotes phosphorylated
T13548 5533-5548 Phosphorylation denotes phosphorylation
T13547 5403-5416 Phosphorylation denotes phosphorylate
T13546 5349-5363 Phosphorylation denotes phosphorylated
T13545 5338-5342 Entity denotes site
T13544 5305-5314 Negative_regulation denotes inability
T13543 5260-5274 Phosphorylation denotes phosphorylated
T13542 5057-5071 Phosphorylation denotes phosphorylated
T13541 4538-4547 Negative_regulation denotes reduction
T13540 4499-4508 Negative_regulation denotes mutations
T13539 4421-4431 Regulation denotes regulation
T13538 4398-4413 Phosphorylation denotes phosphorylation
T13537 4382-4386 Regulation denotes role
T13536 4271-4280 Positive_regulation denotes following
T13535 4255-4270 Phosphorylation denotes phosphorylation
T13534 4238-4247 Positive_regulation denotes increased
T13533 4164-4173 Entity denotes PH domain
T13532 4147-4154 Negative_regulation denotes lacking
T13531 4086-4098 Localization denotes localization
T13530 4009-4016 Regulation denotes effects
T13529 3959-3968 Gene_expression denotes expressed
T13528 3763-3778 Phosphorylation denotes phosphorylation
T13527 3689-3698 Positive_regulation denotes increased
T13526 3637-3652 Phosphorylation denotes phosphorylation
T13525 3570-3584 Phosphorylation denotes phosphorylated
T13524 3466-3475 Positive_regulation denotes increased
T13523 3267-3277 Gene_expression denotes expression
T13522 3258-3262 Positive_regulation denotes upon
R8889 T13454 T13498 themeOf Akt1,expressing
R8890 T13455 T13454 equivalentTo Myr-Akt,Akt1
R8891 T13458 T13500 themeOf Akt1,localization
R8892 T13459 T13458 equivalentTo Myr-Akt,Akt1
R8893 T13460 T13503 themeOf Myr-Akt,expressing
R8894 T13464 T13508 themeOf c-Jun,phosphorylation
R8895 T13465 T13509 themeOf TNFα,upregulation
R8896 T13466 T13513 causeOf RIP1,regulate
R8898 T13471 T13523 themeOf Myr-Akt,expression
R8899 T13474 T13525 themeOf p70S6K,phosphorylated
R8900 T13475 T13525 themeOf S6,phosphorylated
R8901 T13476 T13525 themeOf FoxO4,phosphorylated
R8902 T13477 T13526 themeOf FoxO1,phosphorylation
R8903 T13478 T13526 themeOf MDM2,phosphorylation
R8904 T13479 T13528 themeOf Myr-Akt,phosphorylation
R8905 T13481 T13529 themeOf Myr-Akt,expressed
R8906 T13483 T13542 themeOf S473D mutant,phosphorylated
R8907 T13487 T13548 themeOf c-Jun,phosphorylation
R8908 T13488 T13548 themeOf TNFα,phosphorylation
R8909 T13490 T13549 themeOf T308D,phosphorylated
R8910 T13491 T13549 themeOf Myr-Akt,phosphorylated
R8911 T13494 T13549 themeOf MDM2,phosphorylated
R8912 T13495 T13549 causeOf p70S6K,phosphorylated
R8913 T13506 T13505 themeOf phosphorylation,increase
R8914 T13508 T13507 themeOf phosphorylation,activation
R8915 T13511 T13510 themeOf uncouple,sufficient
R8916 T13512 T13511 themeOf activation,uncouple
R8917 T13514 T13513 themeOf activation,regulate
R8918 T13516 T13515 themeOf changes,required
R8919 T13523 T13521 causeOf expression,increased
R8920 T13523 T13522 themeOf expression,upon
R8921 T13526 T13527 themeOf phosphorylation,increased
R8922 T13533 T13532 themeOf PH domain,lacking
R8923 T13535 T13534 themeOf phosphorylation,increased
R8924 T13535 T13536 themeOf phosphorylation,following
R8925 T13538 T13537 themeOf phosphorylation,role
R8926 T13540 T13541 causeOf mutations,reduction

2_test

Id Subject Object Predicate Lexical cue
23469174-8702995-90505449 412-414 8702995 denotes 37
23469174-8978681-90505450 4619-4621 8978681 denotes 38
23469174-23030823-90505451 5425-5427 23030823 denotes 39

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T14913 6323-6328 NN denotes death
T31429 3033-3040 VB denotes plotted
T31428 3029-3032 VB denotes was
T31427 3018-3028 NN denotes average±SD
T31426 3016-3017 -COMMA- denotes ,
T31425 3010-3016 NN denotes graphs
T31424 3006-3009 DT denotes all
T31423 3003-3005 IN denotes In
T31422 3000-3001 -RRB- denotes )
T31421 2999-3000 NN denotes G
T31420 2998-2999 -LRB- denotes (
T31419 2994-2997 NN denotes hrs
T31418 2992-2993 CD denotes 9
T31417 2989-2991 IN denotes at
T31416 2981-2988 NN denotes qRT-PCR
T31415 2978-2980 IN denotes by
T31414 2971-2977 NN denotes levels
T31413 2966-2970 NN denotes mRNA
T31412 2961-2965 NN denotes TNFα
T31411 2958-2960 IN denotes of
T31410 2947-2957 NN denotes evaluation
T31409 2944-2946 CC denotes or
T31408 2942-2943 -COMMA- denotes ,
T31407 2941-2942 -RRB- denotes )
T31406 2940-2941 NN denotes F
T31405 2939-2940 -LRB- denotes (
T31404 2936-2938 NN denotes hr
T31403 2934-2935 CD denotes 9
T31402 2931-2933 IN denotes at
T31401 2926-2930 NN denotes blot
T31400 2918-2925 JJ denotes western
T31399 2916-2917 -COMMA- denotes ,
T31398 2915-2916 -RRB- denotes )
T31397 2914-2915 NN denotes E
T31396 2913-2914 -LRB- denotes (
T31395 2910-2912 NN denotes hr
T31394 2907-2909 CD denotes 24
T31393 2904-2906 IN denotes at
T31392 2898-2903 NN denotes assay
T31391 2888-2897 NN denotes viability
T31390 2885-2887 IN denotes by
T31389 2876-2884 VB denotes followed
T31388 2874-2875 -COMMA- denotes ,
T31387 2864-2874 NN denotes conditions
T31386 2859-2863 JJ denotes free
T31385 2853-2858 NN denotes serum
T31384 2847-2852 IN denotes under
T31383 2838-2846 NN denotes zVAD.fmk
T31382 2833-2837 IN denotes with
T31381 2825-2832 VB denotes treated
T31380 2820-2824 VB denotes were
T31379 2813-2819 NN denotes Ser473
T31378 2809-2812 CC denotes and
T31377 2802-2808 NN denotes Thr308
T31376 2799-2801 IN denotes of
T31375 2791-2798 NN denotes mutants
T31374 2787-2790 NN denotes Asp
T31373 2783-2786 CC denotes and
T31372 2779-2782 NN denotes Ala
T31371 2775-2778 CC denotes and
T31370 2767-2774 NN denotes Myr-Akt
T31369 2756-2766 VB denotes expressing
T31368 2750-2755 NN denotes cells
T31367 2745-2749 NN denotes L929
T31366 2743-2744 -RRB- denotes )
T31365 2740-2743 NN denotes E-G
T31364 2739-2740 -LRB- denotes (
T31363 2734-2738 NN denotes RNA.
T31362 2730-2733 NN denotes 18S
T31361 2724-2729 NN denotes mouse
T31360 2718-2723 VB denotes using
T31359 2707-2717 VB denotes normalized
T31358 2703-2706 CC denotes and
T31357 2695-2702 NN denotes qRT-PCR
T31356 2692-2694 IN denotes by
T31355 2681-2691 VB denotes determined
T31354 2676-2680 VB denotes were
T31353 2669-2675 NN denotes levels
T31352 2664-2668 NN denotes mRNA
T31351 2659-2663 NN denotes TNFα
T31350 2647-2657 NN denotes conditions
T31349 2642-2646 JJ denotes free
T31348 2636-2641 NN denotes serum
T31347 2630-2635 IN denotes under
T31346 2627-2629 NN denotes hr
T31345 2625-2626 CD denotes 9
T31344 2621-2624 IN denotes for
T31343 2612-2620 NN denotes zVAD.fmk
T31342 2607-2611 IN denotes with
T31341 2596-2606 VB denotes stimulated
T31340 2591-2595 VB denotes were
T31339 2589-2590 -COMMA- denotes ,
T31338 2583-2589 NN denotes K179KM
T31337 2575-2582 NN denotes Myr-Akt
T31336 2571-2574 CC denotes and
T31335 2563-2570 NN denotes Myr-Akt
T31334 2558-2562 IN denotes with
T31333 2549-2557 VB denotes infected
T31332 2542-2548 RB denotes stably
T31331 2540-2541 -COMMA- denotes ,
T31330 2535-2540 NN denotes cells
T31329 2530-2534 NN denotes L929
T31328 2528-2529 -RRB- denotes )
T31327 2527-2528 NN denotes D
T31326 2526-2527 -LRB- denotes (
T31325 2515-2525 VB denotes indicated.
T31324 2511-2514 VB denotes are
T31323 2505-2510 NN denotes bands
T31322 2503-2504 -RRB- denotes )
T31321 2502-2503 SYM denotes *
T31320 2501-2502 -LRB- denotes (
T31279 2276-2285 VB denotes performed
T31278 2271-2275 VB denotes were
T31277 2264-2270 NN denotes assays
T31276 2254-2263 NN denotes Viability
T31275 2251-2252 -RRB- denotes )
T31274 2250-2251 NN denotes B
T31273 2249-2250 -LRB- denotes (
T31272 2243-2248 NN denotes Nec-1
T31271 2238-2242 IN denotes with
T31270 2227-2237 NN denotes conditions
T31269 2222-2226 JJ denotes free
T31268 2216-2221 NN denotes serum
T31267 2213-2215 CC denotes or
T31266 2207-2212 NN denotes serum
T31265 2204-2206 CC denotes or
T31264 2202-2203 -RRB- denotes )
T31263 2201-2202 NN denotes A
T31262 2200-2201 -LRB- denotes (
T31261 2189-2199 NN denotes conditions
T31260 2184-2188 JJ denotes free
T31259 2178-2183 NN denotes serum
T31258 2172-2177 IN denotes under
T31257 2163-2171 NN denotes zVAD.fmk
T31256 2160-2162 IN denotes of
T31255 2151-2159 NN denotes addition
T31254 2147-2150 DT denotes the
T31253 2144-2146 IN denotes by
T31252 2136-2143 VB denotes induced
T31251 2132-2135 VB denotes was
T31250 2120-2131 NN denotes Necroptosis
T31249 2113-2118 NN denotes K179M
T31248 2105-2112 NN denotes Myr-Akt
T31247 2096-2104 JJ denotes inactive
T31246 2082-2095 RB denotes catalytically
T31245 2078-2081 DT denotes the
T31244 2075-2077 CC denotes or
T31243 2067-2074 NN denotes Myr-Akt
T31242 2058-2066 VB denotes encoding
T31241 2050-2057 NN denotes viruses
T31240 2047-2049 CC denotes or
T31239 2036-2046 NN denotes retrovirus
T31238 2031-2035 NN denotes MSCV
T31237 2025-2030 JJ denotes empty
T31236 2020-2024 IN denotes with
T31235 2011-2019 VB denotes infected
T31234 2004-2010 RB denotes stably
T31233 1999-2003 VB denotes were
T31232 1993-1998 NN denotes cells
T31231 1988-1992 NN denotes L929
T31230 1986-1987 -RRB- denotes )
T31229 1985-1986 NN denotes B
T31228 1984-1985 -COMMA- denotes ,
T31227 1983-1984 NN denotes A
T31226 1982-1983 -LRB- denotes (
T31225 1970-1980 NN denotes conditions
T31224 1965-1969 JJ denotes free
T31223 1959-1964 NN denotes serum
T31222 1953-1958 IN denotes under
T31221 1941-1952 NN denotes necroptosis
T31220 1932-1940 VB denotes restores
T31219 1928-1931 NN denotes Akt
T31218 1921-1927 JJ denotes active
T31217 1906-1920 RB denotes constitutively
T31216 1903-1905 IN denotes of
T31215 1892-1902 NN denotes expression
T31319 2493-2500 NN denotes Myr-Akt
T31318 2489-2492 CC denotes and
T31317 2487-2488 -RRB- denotes )
T31316 2486-2487 NN denotes ∼
T31315 2485-2486 -LRB- denotes (
T31314 2481-2484 NN denotes Akt
T31313 2470-2480 JJ denotes Endogenous
T31312 2458-2468 NN denotes antibodies
T31311 2448-2457 JJ denotes indicated
T31310 2444-2447 DT denotes the
T31309 2438-2443 VB denotes using
T31308 2433-2437 NN denotes blot
T31307 2425-2432 JJ denotes western
T31306 2422-2424 IN denotes by
T31305 2413-2421 VB denotes followed
T31304 2411-2412 -COMMA- denotes ,
T31303 2409-2411 NN denotes hr
T31302 2407-2408 CD denotes 9
T31301 2403-2406 IN denotes for
T31300 2392-2402 NN denotes conditions
T31299 2387-2391 JJ denotes free
T31298 2381-2386 NN denotes serum
T31297 2375-2380 IN denotes under
T31296 2369-2374 NN denotes Nec-1
T31295 2362-2368 CC denotes and/or
T31294 2353-2361 NN denotes zVAD.fmk
T31293 2348-2352 IN denotes with
T31292 2340-2347 VB denotes treated
T31291 2335-2339 VB denotes were
T31290 2329-2334 NN denotes cells
T31289 2323-2328 NN denotes K179M
T31288 2315-2322 JJ denotes Myr-Akt
T31287 2311-2314 CC denotes and
T31286 2303-2310 NN denotes Myr-Akt
T31285 2301-2302 -RRB- denotes )
T31284 2300-2301 NN denotes C
T31283 2299-2300 -LRB- denotes (
T31282 2295-2298 NN denotes hr.
T31281 2292-2294 CD denotes 24
T31280 2286-2291 IN denotes after
T14912 6318-6322 NN denotes cell
T14911 6309-6317 JJ denotes eventual
T14910 6305-6308 CC denotes and
T14909 6294-6304 NN denotes activation
T14908 6290-6293 NN denotes JNK
T14907 6288-6289 -COMMA- denotes ,
T14906 6279-6288 NN denotes synthesis
T14905 6274-6278 NN denotes TNFα
T14904 6266-6273 VB denotes promote
T14903 6264-6265 -COMMA- denotes ,
T14902 6253-6264 NN denotes necroptosis
T14901 6246-6252 IN denotes during
T14900 6235-6245 NN denotes substrates
T14899 6221-6234 VB denotes phosphorylate
T14898 6218-6220 TO denotes to
T14897 6214-6217 NN denotes Akt
T14896 6205-6213 VB denotes allowing
T14895 6203-6204 -COMMA- denotes ,
T14894 6197-6203 NN denotes kinase
T14893 6193-6196 NN denotes Akt
T14892 6189-6192 CC denotes and
T14891 6179-6188 NN denotes machinery
T14890 6167-6178 JJ denotes necroptotic
T14889 6159-6166 IN denotes between
T14888 6154-6158 NN denotes link
T14887 6145-6153 JJ denotes critical
T14886 6143-6144 DT denotes a
T14885 6134-6142 VB denotes provides
T14884 6118-6133 NN denotes phosphorylation
T14883 6111-6117 NN denotes Thr308
T14882 6090-6110 JJ denotes necroptosis-specific
T14881 6085-6089 IN denotes that
T14880 6082-6084 VB denotes is
T14879 6080-6081 -COMMA- denotes ,
T14878 6073-6080 NN denotes results
T14877 6067-6072 DT denotes these
T14876 6064-6066 IN denotes on
T14875 6058-6063 VB denotes based
T14874 6056-6057 -COMMA- denotes ,
T14872 6047-6050 PRP-DOLLAR- denotes Our
T14871 6044-6045 -RRB- denotes )
T14870 6041-6044 NN denotes S8D
T14869 6036-6040 NN denotes Fig.
T14868 6035-6036 -LRB- denotes (
T14867 6028-6034 NN denotes p70S6K
T14866 6024-6027 CC denotes and
T14865 6022-6023 -COMMA- denotes ,
T14864 6018-6022 NN denotes MDM2
T14863 6016-6017 -COMMA- denotes ,
T14862 6011-6016 NN denotes Foxo4
T14861 6009-6010 -COMMA- denotes ,
T14860 6004-6009 NN denotes FoxO1
T14850 5945-5947 IN denotes by
T14849 5930-5944 VB denotes phosphorylated
T14848 5925-5929 VB denotes were
T14847 5920-5924 WDT denotes that
T14846 5909-5919 NN denotes substrates
T14845 5901-5908 JJ denotes several
T14844 5898-5900 IN denotes of
T14843 5882-5897 NN denotes phosphorylation
T14842 5871-5881 JJ denotes downstream
T14841 5867-5870 DT denotes the
T14840 5859-5866 VB denotes support
T14839 5855-5858 RB denotes not
T14838 5851-5854 VB denotes did
T14837 5845-5850 NN denotes T308D
T14836 5843-5844 -COMMA- denotes ,
T14835 5837-5843 VB denotes tested
T14834 5832-5836 WRB denotes When
T14833 5825-5830 NN denotes cells
T14832 5821-5824 DT denotes the
T14831 5818-5820 IN denotes in
T14830 5807-5817 NN denotes substrates
T14829 5804-5806 IN denotes of
T14828 5793-5803 NN denotes repertoire
T14827 5786-5792 JJ denotes entire
T14826 5782-5785 DT denotes the
T14825 5768-5781 VB denotes phosphorylate
T14824 5765-5767 TO denotes to
T14823 5756-5764 NN denotes activity
T14822 5745-5755 JJ denotes sufficient
T14821 5740-5744 VB denotes have
T14820 5736-5739 RB denotes not
T14819 5732-5735 MD denotes may
T14818 5725-5731 NN denotes kinase
T14817 5721-5724 DT denotes the
T14816 5718-5720 IN denotes of
T14815 5713-5717 NN denotes form
T14814 5706-5712 JJ denotes mutant
T14813 5701-5705 DT denotes this
T14812 5697-5700 CC denotes and
T14811 5681-5696 NN denotes phosphorylation
T14810 5678-5680 IN denotes of
T14809 5672-5677 NN denotes mimic
T14808 5664-5671 JJ denotes perfect
T14807 5662-5663 DT denotes a
T14806 5659-5661 VB denotes be
T14805 5655-5658 RB denotes not
T14804 5651-5654 MD denotes may
T14803 5649-5650 -COMMA- denotes ,
T14802 5640-5649 NN denotes construct
T14801 5636-5639 NN denotes Akt
T14800 5629-5635 JJ denotes active
T14799 5626-5628 DT denotes an
T14798 5620-5625 VB denotes being
T14797 5617-5619 IN denotes of
T14796 5611-5616 NN denotes spite
T14795 5608-5610 IN denotes in
T14794 5606-5607 -COMMA- denotes ,
T14793 5601-5606 NN denotes T308D
T14792 5596-5600 IN denotes that
T14791 5587-5595 VB denotes suggests
T14790 5582-5586 DT denotes This
T14789 5576-5580 NN denotes mRNA
T14788 5571-5575 NN denotes TNFα
T14787 5567-5570 CC denotes and
T14786 5565-5566 -COMMA- denotes ,
T14785 5560-5565 NN denotes c-Jun
T14784 5556-5559 CC denotes and
T14783 5552-5555 NN denotes JNK
T14782 5549-5551 IN denotes of
T14781 5533-5548 NN denotes phosphorylation
T14780 5531-5532 -COMMA- denotes ,
T14779 5526-5531 NN denotes death
T14778 5521-5525 NN denotes cell
T14777 5511-5520 VB denotes promoting
T14776 5508-5510 IN denotes in
T14775 5501-5507 JJ denotes active
T14774 5496-5500 RB denotes less
T14773 5482-5495 RB denotes significantly
T14772 5477-5481 VB denotes were
T14771 5470-5476 NN denotes Thr308
T14770 5467-5469 IN denotes of
T14769 5459-5466 NN denotes mutants
T14768 5455-5458 NN denotes Asp
T14767 5451-5454 CC denotes and
T14766 5447-5450 NN denotes Ala
T14765 5442-5446 CC denotes both
T14764 5440-5441 -COMMA- denotes ,
T14763 5430-5440 RB denotes Strikingly
T14762 5427-5428 -RRB- denotes ]
T14761 5425-5427 CD denotes 39
T14760 5424-5425 -LRB- denotes [
T14759 5417-5423 NN denotes Thr308
T14758 5403-5416 VB denotes phosphorylate
T14757 5400-5402 TO denotes to
T14756 5395-5399 NN denotes PDK1
T14755 5391-5394 IN denotes for
T14754 5386-5390 NN denotes site
T14753 5378-5385 NN denotes docking
T14752 5376-5377 DT denotes a
T14751 5368-5375 VB denotes provide
T14750 5364-5367 CC denotes and
T14749 5349-5363 VB denotes phosphorylated
T14748 5346-5348 VB denotes be
T14747 5343-5345 TO denotes to
T14746 5338-5342 NN denotes site
T14745 5334-5337 CD denotes 473
T14744 5326-5333 VB denotes mutated
T14743 5322-5325 NNP denotes Ala
T14742 5318-5321 DT denotes the
T14741 5315-5317 IN denotes of
T14740 5305-5314 NN denotes inability
T14739 5301-5304 DT denotes the
T14738 5298-5300 TO denotes to
T14737 5294-5297 JJ denotes due
T14736 5285-5293 RB denotes possibly
T14735 5278-5284 NN denotes Thr308
T14734 5275-5277 IN denotes on
T14733 5260-5274 VB denotes phosphorylated
T14732 5248-5259 RB denotes efficiently
T14731 5245-5247 VB denotes be
T14730 5242-5244 TO denotes to
T14729 5235-5241 JJ denotes unable
T14728 5231-5234 VB denotes was
T14727 5225-5230 NN denotes S473A
T14726 5212-5223 NN denotes necroptosis
T14725 5209-5211 IN denotes of
T14724 5201-5208 NN denotes aspects
T14723 5197-5200 DT denotes all
T14722 5194-5196 IN denotes in
T14721 5187-5193 JJ denotes active
T14720 5182-5186 RB denotes less
T14719 5168-5181 RB denotes significantly
T14718 5164-5167 VB denotes was
T14717 5158-5163 NN denotes S473A
T14716 5152-5157 IN denotes while
T14715 5150-5151 -COMMA- denotes ,
T14714 5142-5150 NN denotes activity
T14713 5134-5141 VB denotes reduced
T14712 5125-5133 RB denotes slightly
T14711 5120-5124 RB denotes only
T14710 5110-5119 VB denotes displayed
T14709 5108-5109 -COMMA- denotes ,
T14708 5104-5108 NN denotes zVAD
T14707 5101-5103 IN denotes of
T14706 5092-5100 NN denotes addition
T14705 5088-5091 DT denotes the
T14704 5082-5087 IN denotes after
T14703 5075-5081 NN denotes Thr308
T14702 5072-5074 IN denotes on
T14701 5057-5071 VB denotes phosphorylated
T14700 5053-5056 VB denotes was
T14699 5047-5052 WDT denotes which
T14698 5045-5046 -COMMA- denotes ,
T14697 5039-5045 NN denotes mutant
T14696 5033-5038 NN denotes S473D
T14695 5029-5032 DT denotes the
T14694 5027-5028 -COMMA- denotes ,
T14693 5019-5027 VB denotes expected
T14692 5016-5018 IN denotes As
T14691 5013-5014 -RRB- denotes )
T14690 5012-5013 NN denotes G
T14689 5011-5012 -COMMA- denotes ,
T14688 5010-5011 NN denotes F
T14687 5009-5010 -COMMA- denotes ,
T14686 5007-5009 NNP denotes 7E
T14685 5002-5006 NNP denotes Fig.
T14684 5001-5002 -LRB- denotes (
T14683 4993-5000 NN denotes changes
T14682 4981-4992 JJ denotes necroptotic
T14681 4973-4980 VB denotes promote
T14680 4970-4972 TO denotes to
T14679 4962-4969 NN denotes ability
T14678 4956-4961 PRP-DOLLAR- denotes their
T14677 4953-4955 IN denotes in
T14676 4941-4952 NN denotes differences
T14675 4935-4940 JJ denotes major
T14674 4925-4934 VB denotes displayed
T14673 4917-4924 NN denotes mutants
T14672 4910-4916 NN denotes Ser473
T14671 4906-4909 CC denotes and
T14670 4899-4905 NN denotes Thr308
T14669 4897-4898 -COMMA- denotes ,
T14668 4887-4897 NN denotes activities
T14667 4877-4886 JJ denotes catalytic
T14666 4869-4876 JJ denotes similar
T14665 4861-4868 IN denotes Despite
T14664 4858-4859 -RRB- denotes )
T14663 4855-4858 NN denotes S8C
T14662 4850-4854 NN denotes Fig.
T14661 4849-4850 -LRB- denotes (
T14660 4840-4848 NN denotes activity
T14659 4837-4839 IN denotes in
T14658 4827-4836 NN denotes decreases
T14657 4816-4826 JJ denotes comparable
T14656 4806-4815 VB denotes displayed
T14655 4798-4805 NN denotes mutants
T14654 4794-4797 NN denotes Ala
T14653 4789-4793 DT denotes both
T14652 4783-4788 IN denotes while
T14651 4781-4782 -COMMA- denotes ,
T14650 4778-4781 NN denotes Akt
T14649 4773-4777 NN denotes type
T14648 4768-4772 JJ denotes wild
T14647 4765-4767 TO denotes to
T14646 4754-4764 JJ denotes comparable
T14645 4745-4753 NN denotes activity
T14644 4735-4744 VB denotes displayed
T14643 4727-4734 NN denotes mutants
T14642 4723-4726 NN denotes Asp
T14641 4718-4722 DT denotes both
T14640 4716-4717 -COMMA- denotes ,
T14639 4711-4716 NN denotes hands
T14638 4707-4710 PRP-DOLLAR- denotes our
T14637 4704-4706 IN denotes In
T14636 4691-4702 NN denotes necroptosis
T14635 4684-4690 IN denotes during
T14602 4512-4518 NN denotes Thr308
T14601 4509-4511 IN denotes at
T14600 4499-4508 NN denotes mutations
T14599 4495-4498 NN denotes Ala
T14598 4490-4494 IN denotes that
T14597 4481-4489 VB denotes reported
T14596 4476-4480 VB denotes been
T14595 4472-4475 VB denotes has
T14594 4469-4471 PRP denotes It
T14593 4464-4468 NNP denotes Akt.
T14592 4461-4463 IN denotes of
T14591 4451-4460 NN denotes functions
T14590 4439-4450 JJ denotes necroptotic
T14589 4435-4438 DT denotes the
T14588 4432-4434 IN denotes of
T14587 4421-4431 NN denotes regulation
T14586 4417-4420 DT denotes the
T14585 4414-4416 IN denotes in
T14584 4398-4413 NN denotes phosphorylation
T14583 4391-4397 NN denotes Thr308
T14582 4387-4390 IN denotes for
T14581 4382-4386 NN denotes role
T14580 4373-4381 JJ denotes critical
T14579 4369-4372 CC denotes and
T14578 4360-4368 JJ denotes specific
T14577 4358-4359 DT denotes a
T14576 4352-4357 VB denotes found
T14575 4349-4351 PRP denotes we
T14574 4347-4348 -COMMA- denotes ,
T14573 4341-4347 RB denotes Second
T14572 4338-4339 -RRB- denotes )
T14571 4337-4338 NN denotes B
T14570 4336-4337 -COMMA- denotes ,
T14569 4333-4336 NN denotes S8A
T14568 4328-4332 NNP denotes Fig.
T14567 4327-4328 -LRB- denotes (
T14566 4316-4326 NN denotes conditions
T14565 4311-4315 JJ denotes free
T14564 4305-4310 NN denotes serum
T14563 4299-4304 IN denotes under
T14562 4290-4298 NN denotes addition
T14561 4281-4289 NN denotes zVAD.fmk
T14560 4271-4280 VB denotes following
T14559 4255-4270 NN denotes phosphorylation
T14558 4248-4254 NN denotes Thr308
T14557 4238-4247 VB denotes increased
T14556 4235-4237 CC denotes or
T14555 4229-4234 NN denotes death
T14554 4224-4228 NN denotes cell
T14553 4221-4223 IN denotes of
T14552 4210-4220 NN denotes activation
T14551 4206-4209 DT denotes the
T14550 4198-4205 VB denotes support
T14549 4194-4197 RB denotes not
T14548 4190-4193 VB denotes did
T14547 4186-4189 NN denotes tag
T14546 4182-4185 NN denotes Myr
T14545 4178-4181 DT denotes the
T14544 4174-4177 CC denotes and
T14543 4167-4173 NN denotes domain
T14542 4164-4166 NN denotes PH
T14541 4160-4163 DT denotes the
T14540 4155-4159 CC denotes both
T14539 4147-4154 VB denotes lacking
T14538 4140-4146 NN denotes mutant
T14537 4138-4139 DT denotes a
T14536 4135-4137 CC denotes or
T14535 4131-4134 NN denotes Akt
T14534 4124-4130 NN denotes length
T14533 4119-4123 JJ denotes Full
T14532 4109-4117 VB denotes required
T14531 4106-4108 VB denotes is
T14530 4102-4105 NN denotes Akt
T14529 4099-4101 IN denotes of
T14528 4086-4098 NN denotes localization
T14527 4077-4085 NN denotes membrane
T14526 4072-4076 IN denotes that
T14525 4066-4071 VB denotes found
T14524 4063-4065 PRP denotes we
T14523 4061-4062 -COMMA- denotes ,
T14522 4056-4061 RB denotes First
T14521 4043-4054 NN denotes necroptosis
T14520 4040-4042 IN denotes on
T14519 4030-4039 NN denotes mutations
T14518 4026-4029 NN denotes Akt
T14517 4020-4025 JJ denotes other
T14516 4017-4019 IN denotes of
T14515 4009-4016 NN denotes effects
T14514 4005-4008 DT denotes the
T14513 3997-4004 VB denotes examine
T14512 3994-3996 TO denotes to
T14511 3991-3993 PRP denotes us
T14510 3983-3990 VB denotes allowed
T14509 3978-3982 DT denotes This
T14508 3969-3977 NNP denotes Myr-Akt.
T14507 3959-3968 VB denotes expressed
T14506 3954-3958 NN denotes over
T14505 3950-3953 DT denotes the
T14504 3947-3949 IN denotes on
T14503 3937-3946 JJ denotes dependent
T14502 3932-3936 VB denotes were
T14501 3930-3931 -RRB- denotes )
T14500 3920-3930 NN denotes production
T14499 3915-3919 NN denotes TNFα
T14498 3913-3914 -COMMA- denotes ,
T14497 3903-3913 NN denotes activation
T14496 3899-3902 NN denotes JNK
T14495 3897-3898 -COMMA- denotes ,
T14494 3892-3897 NN denotes death
T14493 3887-3891 NN denotes cell
T14492 3886-3887 -LRB- denotes (
T14491 3879-3885 NN denotes events
T14490 3868-3878 JJ denotes downstream
T14489 3851-3867 JJ denotes zVAD.fmk-induced
T14488 3847-3850 DT denotes all
T14487 3836-3846 NN denotes conditions
T14486 3831-3835 JJ denotes free
T14485 3825-3830 NN denotes serum
T14484 3819-3824 IN denotes Under
T14483 3809-3817 NN denotes activity
T14482 3805-3808 PRP-DOLLAR- denotes its
T14481 3796-3804 VB denotes promoted
T14480 3790-3795 RB denotes still
T14479 3782-3789 NN denotes Myr-Akt
T14478 3779-3781 IN denotes of
T14477 3763-3778 NN denotes phosphorylation
T14476 3756-3762 NN denotes Thr308
T14475 3744-3755 JJ denotes necroptotic
T14474 3739-3743 IN denotes that
T14473 3728-3738 VB denotes indicating
T14472 3726-3727 -COMMA- denotes ,
T14471 3718-3726 NN denotes zVAD.fmk
T14470 3715-3717 IN denotes of
T14469 3706-3714 NN denotes presence
T14468 3702-3705 DT denotes the
T14467 3699-3701 IN denotes in
T14466 3689-3698 VB denotes increased
T14465 3675-3688 RB denotes significantly
T14464 3671-3674 VB denotes was
T14463 3666-3670 NN denotes MDM2
T14462 3662-3665 CC denotes and
T14461 3656-3661 NN denotes FoxO1
T14460 3653-3655 IN denotes of
T14459 3637-3652 NN denotes phosphorylation
T14458 3635-3636 -COMMA- denotes ,
T14457 3631-3635 NN denotes hand
T14456 3625-3630 JJ denotes other
T14455 3621-3624 DT denotes the
T14454 3618-3620 IN denotes On
T14453 3608-3616 NN denotes zVAD.fmk
T14452 3605-3607 IN denotes of
T14451 3597-3604 NN denotes absence
T14450 3593-3596 DT denotes the
T14449 3590-3592 IN denotes in
T14448 3585-3589 RB denotes even
T14447 3570-3584 VB denotes phosphorylated
T14446 3564-3569 RB denotes fully
T14445 3559-3563 VB denotes were
T14444 3557-3558 -COMMA- denotes ,
T14443 3552-3557 NN denotes FoxO4
T14442 3548-3551 CC denotes and
T14441 3542-3547 NN denotes GSK-3
T14440 3540-3541 -COMMA- denotes ,
T14439 3538-3540 NN denotes S6
T14438 3536-3537 -COMMA- denotes ,
T14437 3530-3536 NN denotes p70S6K
T14436 3520-3529 VB denotes including
T14435 3518-3519 -COMMA- denotes ,
T14434 3508-3518 NN denotes substrates
T14433 3503-3507 DT denotes Some
T14432 3494-3502 NNP denotes Myr-Akt.
T14431 3491-3493 IN denotes of
T14430 3482-3490 NN denotes activity
T14429 3476-3481 JJ denotes basal
T14428 3466-3475 VB denotes increased
T14427 3462-3465 DT denotes the
T14426 3459-3461 TO denotes to
T14425 3455-3458 IN denotes due
T14424 3448-3454 RB denotes likely
T14423 3446-3447 -COMMA- denotes ,
T14422 3440-3446 VB denotes varied
T14421 3424-3439 NN denotes phosphorylation
T14420 3418-3423 PRP-DOLLAR- denotes their
T14419 3415-3417 IN denotes on
T14418 3406-3414 NN denotes zVAD.fmk
T14417 3403-3405 IN denotes of
T14416 3396-3402 NN denotes effect
T14415 3392-3395 DT denotes The
T14414 3389-3390 -RRB- denotes )
T14413 3387-3389 NN denotes 7C
T14859 5994-6003 VB denotes including
T14858 5989-5993 NN denotes zVAD
T14857 5986-5988 IN denotes of
T14856 5977-5985 NN denotes presence
T14855 5973-5976 DT denotes the
T14854 5970-5972 IN denotes in
T14853 5960-5969 NN denotes construct
T14852 5952-5959 JJ denotes Myr-Akt
T14851 5948-5951 DT denotes the
T14412 3382-3386 NN denotes Fig.
T14411 3381-3382 -LRB- denotes (
T14410 3375-3380 NN denotes cells
T14409 3370-3374 NN denotes L929
T14408 3367-3369 IN denotes in
T14407 3356-3366 NN denotes substrates
T14406 3352-3355 NNP denotes Akt
T14405 3348-3351 VB denotes are
T14404 3338-3347 NN denotes molecules
T14403 3332-3337 DT denotes these
T14402 3327-3331 IN denotes that
T14401 3316-3326 VB denotes confirming
T14400 3314-3315 -COMMA- denotes ,
T14399 3308-3314 NN denotes mutant
T14398 3302-3307 NN denotes K179M
T14397 3298-3301 DT denotes the
T14396 3294-3297 RB denotes not
T14395 3290-3293 CC denotes but
T14394 3288-3289 -COMMA- denotes ,
T14393 3281-3288 NN denotes Myr-Akt
T14392 3278-3280 IN denotes of
T14391 3267-3277 NN denotes expression
T14390 3263-3266 DT denotes the
T14389 3258-3262 IN denotes upon
T14388 3248-3257 VB denotes increased
T14387 3244-3247 VB denotes was
T14370 3144-3146 IN denotes as
T14369 3135-3143 NN denotes activity
T14368 3127-3134 NN denotes Myr-Akt
T14367 3117-3126 VB denotes increased
T14366 3105-3116 NN denotes necroptosis
T14365 3098-3104 IN denotes during
T14364 3090-3097 NN denotes Myr-Akt
T14363 3087-3089 IN denotes of
T14358 1830-1841 NN denotes necroptosis
T14357 1823-1829 IN denotes during
T14356 1815-1822 NN denotes changes
T14355 1811-1814 NN denotes Akt
T14354 1807-1810 IN denotes for
T14353 1798-1806 VB denotes required
T14352 1791-1797 NN denotes inputs
T14351 1779-1790 JJ denotes independent
T14350 1775-1778 CD denotes two
T14349 1767-1774 VB denotes provide
T14348 1760-1766 NN denotes kinase
T14347 1755-1759 NN denotes RIP1
T14346 1751-1754 CC denotes and
T14345 1743-1750 NN denotes factors
T14344 1736-1742 NN denotes growth
T14343 1731-1735 IN denotes that
T14342 1720-1730 VB denotes suggesting
T14341 1718-1719 -COMMA- denotes ,
T14340 1707-1718 NN denotes necroptosis
T14339 1700-1706 IN denotes during
T14338 1689-1699 NN denotes activation
T14337 1685-1688 NN denotes Akt
T14336 1676-1684 VB denotes regulate
T14335 1673-1675 TO denotes to
T14334 1668-1672 JJ denotes able
T14333 1662-1667 RB denotes still
T14332 1658-1661 VB denotes was
T14331 1651-1657 NN denotes kinase
T14330 1646-1650 NN denotes RIP1
T14329 1635-1644 NN denotes signaling
T14328 1628-1634 NN denotes factor
T14327 1621-1627 NN denotes growth
T14326 1616-1620 IN denotes from
T14325 1604-1615 NN denotes necroptosis
T14324 1597-1603 IN denotes during
T14323 1586-1596 NN denotes activation
T14322 1582-1585 NN denotes Akt
T14321 1573-1581 VB denotes uncouple
T14320 1570-1572 TO denotes to
T14319 1559-1569 JJ denotes sufficient
T14318 1556-1558 VB denotes is
T14317 1552-1555 NN denotes Akt
T14316 1542-1551 VB denotes localized
T14315 1533-1541 NN denotes membrane
T14314 1529-1532 CC denotes and
T14313 1522-1528 JJ denotes active
T14312 1519-1521 IN denotes of
T14311 1510-1518 NN denotes presence
T14310 1506-1509 DT denotes the
T14309 1501-1505 IN denotes that
T14308 1488-1500 VB denotes demonstrated
T14307 1483-1487 NN denotes data
T14306 1477-1482 DT denotes These
T14305 1466-1475 NN denotes signaling
T14304 1454-1465 JJ denotes necroptotic
T14303 1451-1453 IN denotes of
T14302 1446-1450 NN denotes apex
T14301 1442-1445 DT denotes the
T14300 1439-1441 IN denotes at
T14299 1435-1438 NN denotes Akt
T14298 1431-1434 IN denotes for
T14297 1426-1430 NN denotes role
T14296 1416-1425 JJ denotes important
T14295 1413-1415 DT denotes an
T14294 1402-1412 VB denotes confirming
T14293 1400-1401 -COMMA- denotes ,
T14292 1390-1400 NN denotes conditions
T14291 1385-1389 JJ denotes free
T14290 1379-1384 NN denotes serum
T14289 1373-1378 IN denotes under
T14288 1367-1372 VB denotes occur
T14287 1364-1366 TO denotes to
T14286 1362-1363 -RRB- denotes )
T14285 1360-1362 NN denotes 7D
T14284 1355-1359 NNP denotes Fig.
T14283 1354-1355 -LRB- denotes (
T14282 1349-1353 NN denotes mRNA
T14281 1344-1348 NN denotes TNFα
T14280 1341-1343 IN denotes of
T14279 1328-1340 NN denotes upregulation
T14278 1324-1327 CC denotes and
T14277 1322-1323 -RRB- denotes )
T14276 1320-1322 NN denotes 7C
T14275 1315-1319 NN denotes Fig.
T14274 1314-1315 -LRB- denotes (
T14273 1298-1313 NN denotes phosphorylation
T14272 1292-1297 NN denotes c-Jun
T14271 1288-1291 CC denotes and
T14270 1284-1287 NN denotes JNK
T14269 1281-1283 IN denotes of
T14268 1270-1280 NN denotes activation
T14267 1260-1269 VB denotes including
T14266 1258-1259 -COMMA- denotes ,
T14265 1252-1258 NN denotes events
T14264 1233-1251 JJ denotes zVAD.fmk-dependent
T14263 1227-1232 JJ denotes other
T14262 1219-1226 VB denotes allowed
T14261 1214-1218 RB denotes also
T14260 1206-1213 NN denotes Myr-Akt
T14259 1203-1204 -RRB- denotes )
T14258 1202-1203 NN denotes C
T14257 1201-1202 -COMMA- denotes ,
T14256 1199-1201 NN denotes 7B
T14255 1194-1198 NNP denotes Fig.
T14254 1193-1194 -LRB- denotes (
T14253 1177-1192 NN denotes phosphorylation
T14252 1170-1176 NN denotes Thr308
T14251 1166-1169 NN denotes Akt
T14250 1163-1165 IN denotes in
T14249 1154-1162 NN denotes increase
T14248 1146-1153 VB denotes delayed
T14247 1125-1145 JJ denotes necroptosis-specific
T14246 1121-1124 DT denotes the
T14245 1117-1120 CC denotes and
T14244 1111-1116 NN denotes death
T14243 1106-1110 NN denotes cell
T14242 1096-1105 JJ denotes dependent
T14241 1088-1095 NN denotes Myr-Akt
T14240 1083-1087 CC denotes both
T14239 1073-1082 VB denotes prevented
T14238 1067-1072 NN denotes Nec-1
T14237 1064-1065 -RRB- denotes )
T14236 1063-1064 NN denotes B
T14235 1062-1063 -COMMA- denotes ,
T14234 1060-1062 NNP denotes 7A
T14233 1055-1059 NNP denotes Fig.
T14232 1054-1055 -LRB- denotes (
T14231 1042-1053 NN denotes necroptosis
T14230 1025-1041 JJ denotes zVAD.fmk-induced
T14229 1016-1024 VB denotes restored
T14228 1010-1015 RB denotes fully
T14227 1008-1009 -COMMA- denotes ,
T14226 1002-1008 NN denotes mutant
T14225 996-1001 NN denotes K179M
T14224 992-995 DT denotes the
T14223 988-991 RB denotes not
T14222 984-987 CC denotes but
T14221 982-983 -COMMA- denotes ,
T14220 975-982 NN denotes Myr-Akt
T14219 964-974 NN denotes conditions
T14218 959-963 JJ denotes free
T14217 953-958 NN denotes serum
T14216 947-952 IN denotes Under
T14215 940-945 NN denotes death
T14214 935-939 NN denotes cell
T14213 923-934 JJ denotes necroptotic
T14212 916-922 VB denotes induce
T14211 913-915 TO denotes to
T14210 902-912 JJ denotes sufficient
T14209 898-901 RB denotes not
T14208 895-897 VB denotes is
T14207 889-894 RB denotes alone
T14206 885-888 NN denotes Akt
T14205 878-884 JJ denotes active
T14204 873-877 IN denotes that
T14203 863-872 VB denotes indicates
T14202 858-862 DT denotes This
T14201 855-856 -RRB- denotes )
T14200 853-855 NN denotes 7B
T14199 848-852 NNP denotes Fig.
T14198 847-848 -LRB- denotes (
T14197 836-846 NN denotes starvation
T14196 830-835 NN denotes serum
T14195 827-829 IN denotes by
T14194 815-826 NN denotes necroptosis
T14193 808-814 VB denotes induce
T14192 805-807 TO denotes to
T14191 795-804 VB denotes triggered
T14190 791-794 RB denotes not
T14189 786-790 VB denotes were
T14188 782-785 CC denotes and
T14187 780-781 -COMMA- denotes ,
T14186 775-780 NN denotes cells
T14185 767-774 NN denotes control
T14184 760-766 NN denotes vector
T14183 754-759 JJ denotes empty
T14182 750-753 DT denotes the
T14181 745-749 IN denotes from
T14634 4678-4683 NN denotes sites
T14633 4673-4677 DT denotes both
T14632 4670-4672 IN denotes at
T14631 4662-4669 NN denotes mutants
T14630 4658-4661 NN denotes Asp
T14629 4654-4657 CC denotes and
T14628 4650-4653 NN denotes Ala
T14627 4647-4649 IN denotes of
T14626 4640-4646 NN denotes effect
T14625 4636-4639 DT denotes the
T14624 4627-4635 VB denotes examined
T14623 4624-4626 PRP denotes We
T14622 4621-4622 -RRB- denotes ]
T14621 4619-4621 CD denotes 38
T14620 4618-4619 -LRB- denotes [
T14619 4609-4617 NN denotes activity
T14618 4600-4608 VB denotes increase
T14617 4592-4599 NN denotes mutants
T14616 4588-4591 NN denotes Asp
T14615 4582-4587 IN denotes while
T14614 4580-4581 -COMMA- denotes ,
T14613 4577-4580 NN denotes Akt
T14612 4574-4576 IN denotes of
T14611 4565-4573 NN denotes activity
T14610 4555-4564 JJ denotes catalytic
T14609 4551-4554 DT denotes the
T14608 4548-4550 IN denotes in
T14607 4538-4547 NN denotes reduction
T14606 4536-4537 DT denotes a
T14605 4530-4535 VB denotes cause
T14604 4523-4529 NN denotes Ser473
T14603 4519-4522 CC denotes and
T14180 727-744 JJ denotes indistinguishable
T14179 720-726 NN denotes manner
T14178 718-719 DT denotes a
T14177 715-717 IN denotes in
T14176 710-714 VB denotes grew
T14175 708-709 -COMMA- denotes ,
T14174 702-708 JJ denotes viable
T14173 697-701 VB denotes were
T14172 689-696 NN denotes Myr-Akt
T14171 678-688 VB denotes expressing
T14170 672-677 NN denotes cells
T14169 668-671 DT denotes the
T14168 663-667 IN denotes that
T14167 658-662 VB denotes note
T14166 655-657 TO denotes to
T14165 645-654 JJ denotes important
T14164 642-644 VB denotes is
T14163 639-641 PRP denotes It
T14162 633-637 JJ denotes free
T14161 627-632 NN denotes serum
T14160 621-626 IN denotes under
T14159 614-620 JJ denotes active
T14158 611-613 VB denotes is
T14157 606-610 WDT denotes that
T14156 602-605 NN denotes Akt
T14155 599-601 DT denotes an
T14386 3233-3243 NN denotes substrates
T14385 3229-3232 NN denotes Akt
T14384 3219-3228 VB denotes described
T14383 3208-3218 RB denotes previously
T14382 3203-3207 JJ denotes many
T14381 3200-3202 IN denotes of
T14380 3184-3199 NN denotes Phosphorylation
T14379 3181-3182 -RRB- denotes )
T14378 3180-3181 CD denotes 5
T14377 3175-3179 NNP denotes Fig.
T14376 3174-3175 -LRB- denotes (
T14375 3170-3173 NN denotes Akt
T14374 3159-3169 JJ denotes endogenous
T14373 3154-3158 IN denotes with
T14372 3150-3153 VB denotes did
T14371 3147-3149 PRP denotes it
T14154 596-598 IN denotes in
T14153 586-595 VB denotes resulting
T14152 584-585 -RRB- denotes )
T14151 582-584 NN denotes 7A
T14150 577-581 NN denotes Fig.
T14149 576-577 -LRB- denotes (
T14148 569-575 NN denotes domain
T14147 566-568 NN denotes PH
T14146 550-565 JJ denotes auto-inhibitory
T14145 546-549 DT denotes the
T14144 543-545 IN denotes of
T14143 534-542 NN denotes deletion
T14142 530-533 DT denotes the
T14141 527-529 IN denotes by
T14140 523-526 CC denotes and
T14139 514-522 NN denotes membrane
T14138 507-513 NN denotes plasma
T14137 503-506 DT denotes the
T14136 500-502 TO denotes to
T14135 487-499 NN denotes localization
T14134 474-486 JJ denotes constitutive
T14133 465-473 VB denotes provides
T14132 459-464 WDT denotes which
T14131 452-458 NN denotes signal
T14130 437-451 NN denotes myristoylation
T14129 435-436 DT denotes a
T14128 432-434 IN denotes of
T14127 423-431 NN denotes addition
T14126 419-422 DT denotes the
T14125 416-418 IN denotes by
T14124 414-415 -RRB- denotes ]
T14123 412-414 CD denotes 37
T14122 411-412 -LRB- denotes [
T14121 401-410 VB denotes described
T14120 390-400 RB denotes previously
T14119 387-389 IN denotes as
T14118 377-386 VB denotes generated
T14117 373-376 VB denotes was
T14116 371-372 -RRB- denotes )
T14115 364-371 NN denotes Myr-Akt
T14114 363-364 -LRB- denotes (
T14113 358-362 NN denotes Akt1
T14112 351-357 JJ denotes active
T14111 336-350 RB denotes Constitutively
T14110 323-334 NN denotes necroptosis
T14109 316-322 IN denotes during
T14108 305-315 NN denotes activation
T14107 301-304 NN denotes Akt
T14106 298-300 TO denotes to
T14105 291-297 NN denotes kinase
T14104 286-290 NN denotes RIP1
T14103 282-285 CC denotes and
T14102 274-281 NN denotes factors
T14101 267-273 NN denotes growth
T14100 264-266 IN denotes of
T14099 251-263 NN denotes contribution
T14098 247-250 DT denotes the
T14097 236-246 VB denotes understand
T14096 228-235 RB denotes further
T14095 225-227 TO denotes to
T14094 219-224 NN denotes order
T14093 216-218 IN denotes in
T14092 210-215 NN denotes K179M
T14091 203-209 JJ denotes mutant
T14090 194-202 JJ denotes inactive
T14089 180-193 RB denotes catalytically
T14088 176-179 DT denotes the
T14087 173-175 CC denotes or
T14086 171-172 -RRB- denotes )
T14085 164-171 NN denotes Myr-Akt
T14084 163-164 -LRB- denotes (
T14083 158-162 NN denotes Akt1
T14082 153-157 NN denotes type
T14081 148-152 JJ denotes wild
T14080 141-147 JJ denotes active
T14079 126-140 RB denotes constitutively
T14078 115-125 VB denotes expressing
T14077 108-114 RB denotes stably
T14076 102-107 NN denotes cells
T14075 97-101 NN denotes L929
T14074 92-96 VB denotes used
T14073 89-91 PRP denotes We
T14072 78-88 NNP denotes Conditions
T14071 73-77 NNP denotes Free
T14070 67-72 NNP denotes Serum
T14069 61-66 NNP denotes Under
T14068 49-60 NNP denotes Necroptosis
T14067 41-48 NNP denotes Rescues
T14066 39-40 -COMMA- denotes ,
T14065 36-39 NNP denotes Akt
T14064 29-35 JJ denotes Active
T14063 14-28 RB denotes Constitutively
T14062 11-13 IN denotes of
T14061 0-10 NN denotes Expression
T14873 6051-6056 NN denotes model
T31214 1887-1891 IN denotes Over
R9042 T14061 T14062 arg1Of Expression,of
R9043 T14064 T14063 arg1Of Active,Constitutively
R9044 T14065 T14062 arg2Of Akt,of
R9045 T14065 T14064 arg1Of Akt,Active
R9046 T14065 T14066 arg1Of Akt,","
R9047 T14071 T14067 arg1Of Free,Rescues
R9048 T14071 T14068 arg1Of Free,Necroptosis
R9049 T14071 T14069 arg1Of Free,Under
R9050 T14071 T14070 arg1Of Free,Serum
R9051 T14072 T14066 arg2Of Conditions,","
R9052 T14072 T14071 arg1Of Conditions,Free
R9053 T14073 T14074 arg1Of We,used
R9054 T14076 T14074 arg2Of cells,used
R9055 T14076 T14075 arg1Of cells,L929
R9056 T14076 T14078 arg1Of cells,expressing
R9057 T14076 T14097 arg1Of cells,understand
R9058 T14078 T14077 arg1Of expressing,stably
R9059 T14078 T14093 arg1Of expressing,in
R9060 T14080 T14079 arg1Of active,constitutively
R9061 T14083 T14080 arg1Of Akt1,active
R9062 T14083 T14081 arg1Of Akt1,wild
R9063 T14083 T14082 arg1Of Akt1,type
R9064 T14083 T14084 arg1Of Akt1,(
R9065 T14083 T14087 arg1Of Akt1,or
R9066 T14085 T14084 arg2Of Myr-Akt,(
R9067 T14086 T14084 arg3Of ),(
R9068 T14087 T14078 arg2Of or,expressing
R9069 T14092 T14087 arg2Of K179M,or
R9070 T14092 T14088 arg1Of K179M,the
R9071 T14092 T14089 arg1Of K179M,catalytically
R9072 T14092 T14090 arg1Of K179M,inactive
R9073 T14092 T14091 arg1Of K179M,mutant
R9074 T14094 T14093 arg2Of order,in
R9075 T14097 T14093 arg3Of understand,in
R9076 T14097 T14095 arg1Of understand,to
R9077 T14097 T14096 arg1Of understand,further
R9078 T14099 T14097 arg2Of contribution,understand
R9079 T14099 T14098 arg1Of contribution,the
R9080 T14099 T14100 arg1Of contribution,of
R9081 T14099 T14106 arg1Of contribution,to
R9082 T14102 T14101 arg1Of factors,growth
R9083 T14102 T14103 arg1Of factors,and
R9084 T14103 T14100 arg2Of and,of
R9085 T14105 T14103 arg2Of kinase,and
R9086 T14105 T14104 arg1Of kinase,RIP1
R9087 T14108 T14106 arg2Of activation,to
R9088 T14108 T14107 arg1Of activation,Akt
R9089 T14108 T14109 arg1Of activation,during
R9090 T14110 T14109 arg2Of necroptosis,during
R9091 T14112 T14111 arg1Of active,Constitutively
R9092 T14113 T14112 arg1Of Akt1,active
R9093 T14113 T14114 arg1Of Akt1,(
R9094 T14113 T14117 arg1Of Akt1,was
R9095 T14113 T14118 arg2Of Akt1,generated
R9096 T14115 T14114 arg2Of Myr-Akt,(
R9097 T14116 T14114 arg3Of ),(
R9098 T14118 T14117 arg2Of generated,was
R9099 T14118 T14119 arg1Of generated,as
R9100 T14118 T14125 arg1Of generated,by
R9101 T14118 T14141 arg1Of generated,by
R9102 T14121 T14120 arg1Of described,previously
R9103 T14123 T14119 arg2Of 37,as
R9104 T14123 T14121 arg1Of 37,described
R9105 T14123 T14122 arg2Of 37,[
R9106 T14124 T14122 arg3Of ],[
R9107 T14125 T14140 arg1Of by,and
R9108 T14127 T14125 arg2Of addition,by
R9109 T14127 T14126 arg1Of addition,the
R9110 T14127 T14128 arg1Of addition,of
R9111 T14131 T14128 arg2Of signal,of
R9112 T14131 T14129 arg1Of signal,a
R9113 T14131 T14130 arg1Of signal,myristoylation
R9114 T14131 T14132 arg1Of signal,which
R9115 T14131 T14133 arg1Of signal,provides
R9116 T14135 T14133 arg2Of localization,provides
R9117 T14135 T14134 arg1Of localization,constitutive
R9118 T14135 T14136 arg1Of localization,to
R9119 T14139 T14136 arg2Of membrane,to
R9120 T14139 T14137 arg1Of membrane,the
R9121 T14139 T14138 arg1Of membrane,plasma
R9122 T14141 T14140 arg2Of by,and
R9123 T14143 T14141 arg2Of deletion,by
R9124 T14143 T14142 arg1Of deletion,the
R9125 T14143 T14144 arg1Of deletion,of
R9126 T14148 T14144 arg2Of domain,of
R9127 T14148 T14145 arg1Of domain,the
R9128 T14148 T14146 arg1Of domain,auto-inhibitory
R9129 T14148 T14147 arg1Of domain,PH
R9130 T14148 T14149 arg1Of domain,(
R9131 T14148 T14153 arg1Of domain,resulting
R9132 T14151 T14149 arg2Of 7A,(
R9133 T14151 T14150 arg1Of 7A,Fig.
R9134 T14152 T14149 arg3Of ),(
R9135 T14153 T14154 arg1Of resulting,in
R9136 T14156 T14154 arg2Of Akt,in
R9137 T14156 T14155 arg1Of Akt,an
R9138 T14156 T14157 arg1Of Akt,that
R9139 T14156 T14158 arg1Of Akt,is
R9140 T14156 T14159 arg1Of Akt,active
R9141 T14159 T14158 arg2Of active,is
R9142 T14159 T14160 arg1Of active,under
R9143 T14161 T14160 arg2Of serum,under
R9144 T14161 T14162 arg1Of serum,free
R9145 T14165 T14164 arg2Of important,is
R9146 T14167 T14166 arg1Of note,to
R9147 T14167 T14176 arg1Of note,grew
R9148 T14167 T14189 arg1Of note,were
R9149 T14167 T14191 arg2Of note,triggered
R9150 T14170 T14169 arg1Of cells,the
R9151 T14170 T14171 arg1Of cells,expressing
R9152 T14170 T14173 arg1Of cells,were
R9153 T14170 T14174 arg1Of cells,viable
R9154 T14172 T14171 arg2Of Myr-Akt,expressing
R9155 T14173 T14167 arg2Of were,note
R9156 T14173 T14168 arg1Of were,that
R9157 T14174 T14173 arg2Of viable,were
R9158 T14176 T14177 arg1Of grew,in
R9159 T14176 T14188 arg1Of grew,and
R9160 T14179 T14177 arg2Of manner,in
R9161 T14179 T14178 arg1Of manner,a
R9162 T14179 T14180 arg1Of manner,indistinguishable
R9163 T14180 T14181 arg1Of indistinguishable,from
R9164 T14186 T14181 arg2Of cells,from
R9165 T14186 T14182 arg1Of cells,the
R9166 T14186 T14183 arg1Of cells,empty
R9167 T14186 T14184 arg1Of cells,vector
R9168 T14186 T14185 arg1Of cells,control
R9169 T14188 T14163 arg1Of and,It
R9170 T14188 T14164 arg1Of and,is
R9171 T14188 T14165 arg1Of and,important
R9172 T14188 T14175 arg1Of and,","
R9173 T14188 T14187 arg1Of and,","
R9174 T14191 T14188 arg2Of triggered,and
R9175 T14191 T14189 arg2Of triggered,were
R9176 T14191 T14190 arg1Of triggered,not
R9177 T14191 T14192 modOf triggered,to
R9178 T14193 T14192 arg1Of induce,to
R9179 T14193 T14195 arg1Of induce,by
R9180 T14194 T14193 arg2Of necroptosis,induce
R9181 T14197 T14195 arg2Of starvation,by
R9182 T14197 T14196 arg1Of starvation,serum
R9183 T14197 T14198 arg1Of starvation,(
R9184 T14200 T14198 arg2Of 7B,(
R9185 T14200 T14199 arg1Of 7B,Fig.
R9186 T14201 T14198 arg3Of ),(
R9187 T14202 T14203 arg1Of This,indicates
R9188 T14206 T14205 arg1Of Akt,active
R9189 T14206 T14207 arg1Of Akt,alone
R9190 T14206 T14208 arg1Of Akt,is
R9191 T14206 T14210 arg1Of Akt,sufficient
R9192 T14208 T14203 arg2Of is,indicates
R9193 T14208 T14204 arg1Of is,that
R9194 T14208 T14209 arg1Of is,not
R9195 T14210 T14208 arg2Of sufficient,is
R9196 T14212 T14210 arg2Of induce,sufficient
R9197 T14212 T14211 arg1Of induce,to
R9198 T14215 T14212 arg2Of death,induce
R9199 T14215 T14213 arg1Of death,necroptotic
R9200 T14215 T14214 arg1Of death,cell
R9201 T14219 T14216 arg2Of conditions,Under
R9202 T14219 T14217 arg1Of conditions,serum
R9203 T14219 T14218 arg1Of conditions,free
R9204 T14220 T14222 arg1Of Myr-Akt,but
R9205 T14222 T14221 arg1Of but,","
R9206 T14222 T14223 arg1Of but,not
R9207 T14222 T14229 arg1Of but,restored
R9208 T14226 T14222 arg2Of mutant,but
R9209 T14226 T14224 arg1Of mutant,the
R9210 T14226 T14225 arg1Of mutant,K179M
R9211 T14229 T14216 arg1Of restored,Under
R9212 T14229 T14227 arg1Of restored,","
R9213 T14229 T14228 arg1Of restored,fully
R9214 T14231 T14229 arg2Of necroptosis,restored
R9215 T14231 T14230 arg1Of necroptosis,zVAD.fmk-induced
R9216 T14231 T14232 arg1Of necroptosis,(
R9217 T14234 T14232 arg2Of 7A,(
R9218 T14234 T14233 arg1Of 7A,Fig.
R9219 T14234 T14235 arg1Of 7A,","
R9220 T14236 T14235 arg2Of B,","
R9221 T14237 T14232 arg3Of ),(
R9222 T14238 T14239 arg1Of Nec-1,prevented
R9223 T14239 T14254 arg1Of prevented,(
R9224 T14242 T14241 arg1Of dependent,Myr-Akt
R9225 T14244 T14240 arg1Of death,both
R9226 T14244 T14242 arg1Of death,dependent
R9227 T14244 T14243 arg1Of death,cell
R9228 T14244 T14245 arg1Of death,and
R9229 T14245 T14239 arg2Of and,prevented
R9230 T14249 T14245 arg2Of increase,and
R9231 T14249 T14246 arg1Of increase,the
R9232 T14249 T14247 arg1Of increase,necroptosis-specific
R9233 T14249 T14248 arg2Of increase,delayed
R9234 T14249 T14250 arg1Of increase,in
R9235 T14253 T14250 arg2Of phosphorylation,in
R9236 T14253 T14251 arg1Of phosphorylation,Akt
R9237 T14253 T14252 arg1Of phosphorylation,Thr308
R9238 T14256 T14254 arg2Of 7B,(
R9239 T14256 T14255 arg1Of 7B,Fig.
R9240 T14256 T14257 arg1Of 7B,","
R9241 T14258 T14257 arg2Of C,","
R9242 T14259 T14254 arg3Of ),(
R9243 T14260 T14262 arg1Of Myr-Akt,allowed
R9244 T14262 T14261 arg1Of allowed,also
R9245 T14262 T14293 arg1Of allowed,","
R9246 T14262 T14294 modOf allowed,confirming
R9247 T14265 T14262 arg2Of events,allowed
R9248 T14265 T14263 arg1Of events,other
R9249 T14265 T14264 arg1Of events,zVAD.fmk-dependent
R9250 T14265 T14266 arg1Of events,","
R9251 T14265 T14267 arg1Of events,including
R9252 T14265 T14288 arg1Of events,occur
R9253 T14268 T14269 arg1Of activation,of
R9254 T14268 T14271 arg1Of activation,and
R9255 T14270 T14269 arg2Of JNK,of
R9256 T14271 T14278 arg1Of and,and
R9257 T14273 T14271 arg2Of phosphorylation,and
R9258 T14273 T14272 arg1Of phosphorylation,c-Jun
R9259 T14273 T14274 arg1Of phosphorylation,(
R9260 T14276 T14274 arg2Of 7C,(
R9261 T14276 T14275 arg1Of 7C,Fig.
R9262 T14277 T14274 arg3Of ),(
R9263 T14278 T14267 arg2Of and,including
R9264 T14279 T14278 arg2Of upregulation,and
R9265 T14279 T14280 arg1Of upregulation,of
R9266 T14282 T14280 arg2Of mRNA,of
R9267 T14282 T14281 arg1Of mRNA,TNFα
R9268 T14282 T14283 arg1Of mRNA,(
R9269 T14285 T14283 arg2Of 7D,(
R9270 T14285 T14284 arg1Of 7D,Fig.
R9271 T14286 T14283 arg3Of ),(
R9272 T14288 T14262 arg3Of occur,allowed
R9273 T14288 T14287 arg1Of occur,to
R9274 T14288 T14289 arg1Of occur,under
R9275 T14292 T14289 arg2Of conditions,under
R9276 T14292 T14290 arg1Of conditions,serum
R9277 T14292 T14291 arg1Of conditions,free
R9278 T14297 T14294 arg2Of role,confirming
R9279 T14297 T14295 arg1Of role,an
R9280 T14297 T14296 arg1Of role,important
R9281 T14297 T14298 arg1Of role,for
R9282 T14297 T14300 arg1Of role,at
R9283 T14299 T14298 arg2Of Akt,for
R9284 T14302 T14300 arg2Of apex,at
R9285 T14302 T14301 arg1Of apex,the
R9286 T14302 T14303 arg1Of apex,of
R9287 T14305 T14303 arg2Of signaling,of
R9288 T14305 T14304 arg1Of signaling,necroptotic
R9289 T14307 T14306 arg1Of data,These
R9290 T14307 T14308 arg1Of data,demonstrated
R9291 T14311 T14310 arg1Of presence,the
R9292 T14311 T14312 arg1Of presence,of
R9293 T14311 T14318 arg1Of presence,is
R9294 T14311 T14319 arg1Of presence,sufficient
R9295 T14317 T14312 arg2Of Akt,of
R9296 T14317 T14313 arg1Of Akt,active
R9297 T14317 T14314 arg1Of Akt,and
R9298 T14317 T14315 arg1Of Akt,membrane
R9299 T14317 T14316 arg2Of Akt,localized
R9300 T14318 T14308 arg2Of is,demonstrated
R9301 T14318 T14309 arg1Of is,that
R9302 T14319 T14318 arg2Of sufficient,is
R9303 T14321 T14319 arg2Of uncouple,sufficient
R9304 T14321 T14320 arg1Of uncouple,to
R9305 T14321 T14324 arg1Of uncouple,during
R9306 T14323 T14321 arg2Of activation,uncouple
R9307 T14323 T14322 arg1Of activation,Akt
R9308 T14325 T14324 arg2Of necroptosis,during
R9309 T14325 T14326 arg1Of necroptosis,from
R9310 T14329 T14326 arg2Of signaling,from
R9311 T14329 T14327 arg1Of signaling,growth
R9312 T14329 T14328 arg1Of signaling,factor
R9313 T14331 T14330 arg1Of kinase,RIP1
R9314 T14331 T14332 arg1Of kinase,was
R9315 T14331 T14334 arg1Of kinase,able
R9316 T14331 T14336 arg1Of kinase,regulate
R9317 T14332 T14333 arg1Of was,still
R9318 T14332 T14341 arg1Of was,","
R9319 T14332 T14342 modOf was,suggesting
R9320 T14334 T14332 arg2Of able,was
R9321 T14336 T14334 arg2Of regulate,able
R9322 T14336 T14335 arg1Of regulate,to
R9323 T14336 T14339 arg1Of regulate,during
R9324 T14338 T14336 arg2Of activation,regulate
R9325 T14338 T14337 arg1Of activation,Akt
R9326 T14340 T14339 arg2Of necroptosis,during
R9327 T14345 T14344 arg1Of factors,growth
R9328 T14345 T14346 arg1Of factors,and
R9329 T14346 T14349 arg1Of and,provide
R9330 T14348 T14346 arg2Of kinase,and
R9331 T14348 T14347 arg1Of kinase,RIP1
R9332 T14349 T14342 arg2Of provide,suggesting
R9333 T14349 T14343 arg1Of provide,that
R9334 T14352 T14349 arg2Of inputs,provide
R9335 T14352 T14350 arg1Of inputs,two
R9336 T14352 T14351 arg1Of inputs,independent
R9337 T14352 T14353 arg2Of inputs,required
R9338 T14353 T14354 arg1Of required,for
R9339 T14356 T14354 arg2Of changes,for
R9340 T14356 T14355 arg1Of changes,Akt
R9341 T14356 T14357 arg1Of changes,during
R9342 T14358 T14357 arg2Of necroptosis,during
R9349 T14364 T14363 arg2Of Myr-Akt,of
R9350 T14366 T14365 arg2Of necroptosis,during
R9351 T14369 T14367 arg2Of activity,increased
R9352 T14369 T14368 arg1Of activity,Myr-Akt
R9353 T14370 T14367 arg3Of as,increased
R9354 T14371 T14372 arg1Of it,did
R9355 T14372 T14370 arg2Of did,as
R9356 T14372 T14373 arg1Of did,with
R9357 T14372 T14376 arg1Of did,(
R9358 T14375 T14373 arg2Of Akt,with
R9359 T14375 T14374 arg1Of Akt,endogenous
R9360 T14377 T14376 arg2Of Fig.,(
R9361 T14377 T14378 arg1Of Fig.,5
R9362 T14379 T14376 arg3Of ),(
R9363 T14380 T14381 arg1Of Phosphorylation,of
R9364 T14380 T14387 arg1Of Phosphorylation,was
R9365 T14380 T14388 arg2Of Phosphorylation,increased
R9366 T14384 T14383 arg1Of described,previously
R9367 T14386 T14381 arg2Of substrates,of
R9368 T14386 T14382 arg1Of substrates,many
R9369 T14386 T14384 arg1Of substrates,described
R9370 T14386 T14385 arg1Of substrates,Akt
R9371 T14388 T14387 arg2Of increased,was
R9372 T14388 T14389 arg1Of increased,upon
R9373 T14388 T14400 arg1Of increased,","
R9374 T14388 T14401 modOf increased,confirming
R9375 T14391 T14390 arg1Of expression,the
R9376 T14391 T14392 arg1Of expression,of
R9377 T14391 T14395 arg1Of expression,but
R9378 T14393 T14392 arg2Of Myr-Akt,of
R9379 T14395 T14389 arg2Of but,upon
R9380 T14395 T14394 arg1Of but,","
R9381 T14395 T14396 arg1Of but,not
R9382 T14399 T14395 arg2Of mutant,but
R9383 T14399 T14397 arg1Of mutant,the
R9384 T14399 T14398 arg1Of mutant,K179M
R9385 T14404 T14403 arg1Of molecules,these
R9386 T14404 T14405 arg1Of molecules,are
R9387 T14405 T14401 arg2Of are,confirming
R9388 T14405 T14402 arg1Of are,that
R9389 T14405 T14408 arg1Of are,in
R9390 T14407 T14405 arg2Of substrates,are
R9391 T14407 T14406 arg1Of substrates,Akt
R9392 T14410 T14408 arg2Of cells,in
R9393 T14410 T14409 arg1Of cells,L929
R9394 T14410 T14411 arg1Of cells,(
R9395 T14413 T14411 arg2Of 7C,(
R9396 T14413 T14412 arg1Of 7C,Fig.
R9397 T14414 T14411 arg3Of ),(
R9398 T14416 T14415 arg1Of effect,The
R9399 T14416 T14417 arg1Of effect,of
R9400 T14416 T14419 arg1Of effect,on
R9401 T14416 T14422 arg1Of effect,varied
R9402 T14418 T14417 arg2Of zVAD.fmk,of
R9403 T14421 T14419 arg2Of phosphorylation,on
R9404 T14421 T14420 arg1Of phosphorylation,their
R9405 T14422 T14423 arg1Of varied,","
R9406 T14422 T14424 arg1Of varied,likely
R9407 T14422 T14425 arg1Of varied,due
R9408 T14425 T14426 arg1Of due,to
R9409 T14430 T14425 arg2Of activity,due
R9410 T14430 T14427 arg1Of activity,the
R9411 T14430 T14428 arg2Of activity,increased
R9412 T14430 T14429 arg1Of activity,basal
R9413 T14430 T14431 arg1Of activity,of
R9414 T14432 T14431 arg2Of Myr-Akt.,of
R9415 T14434 T14433 arg1Of substrates,Some
R9416 T14434 T14435 arg1Of substrates,","
R9417 T14434 T14436 arg1Of substrates,including
R9418 T14434 T14445 arg1Of substrates,were
R9419 T14434 T14447 arg2Of substrates,phosphorylated
R9420 T14437 T14438 arg1Of p70S6K,","
R9421 T14438 T14440 arg1Of ",",","
R9422 T14439 T14438 arg2Of S6,","
R9423 T14440 T14442 arg1Of ",",and
R9424 T14441 T14440 arg2Of GSK-3,","
R9425 T14442 T14436 arg2Of and,including
R9426 T14443 T14442 arg2Of FoxO4,and
R9427 T14447 T14422 arg2Of phosphorylated,varied
R9428 T14447 T14444 arg1Of phosphorylated,","
R9429 T14447 T14445 arg2Of phosphorylated,were
R9430 T14447 T14446 arg1Of phosphorylated,fully
R9431 T14447 T14449 arg1Of phosphorylated,in
R9432 T14449 T14448 arg1Of in,even
R9433 T14451 T14449 arg2Of absence,in
R9434 T14451 T14450 arg1Of absence,the
R9435 T14451 T14452 arg1Of absence,of
R9436 T14453 T14452 arg2Of zVAD.fmk,of
R9437 T14457 T14454 arg2Of hand,On
R9438 T14457 T14455 arg1Of hand,the
R9439 T14457 T14456 arg1Of hand,other
R9440 T14459 T14460 arg1Of phosphorylation,of
R9441 T14459 T14464 arg1Of phosphorylation,was
R9442 T14459 T14466 arg2Of phosphorylation,increased
R9443 T14461 T14462 arg1Of FoxO1,and
R9444 T14462 T14460 arg2Of and,of
R9445 T14463 T14462 arg2Of MDM2,and
R9446 T14466 T14454 arg1Of increased,On
R9447 T14466 T14458 arg1Of increased,","
R9448 T14466 T14464 arg2Of increased,was
R9449 T14466 T14465 arg1Of increased,significantly
R9450 T14466 T14467 arg1Of increased,in
R9451 T14466 T14472 arg1Of increased,","
R9452 T14466 T14473 modOf increased,indicating
R9453 T14467 T14468 arg1Of in,the
R9454 T14467 T14470 arg1Of in,of
R9455 T14469 T14467 arg2Of presence,in
R9456 T14471 T14467 arg3Of zVAD.fmk,in
R9457 T14477 T14475 arg1Of phosphorylation,necroptotic
R9458 T14477 T14476 arg1Of phosphorylation,Thr308
R9459 T14477 T14478 arg1Of phosphorylation,of
R9460 T14477 T14481 arg1Of phosphorylation,promoted
R9461 T14479 T14478 arg2Of Myr-Akt,of
R9462 T14481 T14473 arg2Of promoted,indicating
R9463 T14481 T14474 arg1Of promoted,that
R9464 T14481 T14480 arg1Of promoted,still
R9465 T14483 T14481 arg2Of activity,promoted
R9466 T14483 T14482 arg1Of activity,its
R9467 T14487 T14484 arg2Of conditions,Under
R9468 T14487 T14485 arg1Of conditions,serum
R9469 T14487 T14486 arg1Of conditions,free
R9470 T14491 T14488 arg1Of events,all
R9471 T14491 T14489 arg1Of events,zVAD.fmk-induced
R9472 T14491 T14490 arg1Of events,downstream
R9473 T14491 T14492 arg1Of events,(
R9474 T14491 T14502 arg1Of events,were
R9475 T14491 T14503 arg1Of events,dependent
R9476 T14494 T14492 arg2Of death,(
R9477 T14494 T14493 arg1Of death,cell
R9478 T14494 T14495 arg1Of death,","
R9479 T14494 T14498 arg1Of death,","
R9480 T14497 T14495 arg2Of activation,","
R9481 T14497 T14496 arg1Of activation,JNK
R9482 T14500 T14498 arg2Of production,","
R9483 T14500 T14499 arg1Of production,TNFα
R9484 T14501 T14492 arg3Of ),(
R9485 T14502 T14484 arg1Of were,Under
R9486 T14502 T14504 arg1Of were,on
R9487 T14503 T14502 arg2Of dependent,were
R9488 T14506 T14505 arg1Of over,the
R9489 T14506 T14507 arg1Of over,expressed
R9490 T14507 T14504 arg2Of expressed,on
R9491 T14508 T14507 arg2Of Myr-Akt.,expressed
R9492 T14508 T14510 arg1Of Myr-Akt.,allowed
R9493 T14510 T14507 arg3Of allowed,expressed
R9494 T14510 T14509 arg1Of allowed,This
R9495 T14511 T14510 arg2Of us,allowed
R9496 T14511 T14513 arg1Of us,examine
R9497 T14513 T14510 arg3Of examine,allowed
R9498 T14513 T14512 arg1Of examine,to
R9499 T14515 T14513 arg2Of effects,examine
R9500 T14515 T14514 arg1Of effects,the
R9501 T14515 T14516 arg1Of effects,of
R9502 T14515 T14520 arg1Of effects,on
R9503 T14519 T14516 arg2Of mutations,of
R9504 T14519 T14517 arg1Of mutations,other
R9505 T14519 T14518 arg1Of mutations,Akt
R9506 T14521 T14520 arg2Of necroptosis,on
R9507 T14524 T14525 arg1Of we,found
R9508 T14525 T14522 arg1Of found,First
R9509 T14525 T14523 arg1Of found,","
R9510 T14528 T14527 arg1Of localization,membrane
R9511 T14528 T14529 arg1Of localization,of
R9512 T14528 T14531 arg1Of localization,is
R9513 T14528 T14532 arg2Of localization,required
R9514 T14530 T14529 arg2Of Akt,of
R9515 T14532 T14525 arg2Of required,found
R9516 T14532 T14526 arg1Of required,that
R9517 T14532 T14531 arg2Of required,is
R9518 T14535 T14533 arg1Of Akt,Full
R9519 T14535 T14534 arg1Of Akt,length
R9520 T14535 T14536 arg1Of Akt,or
R9521 T14536 T14548 arg1Of or,did
R9522 T14536 T14550 arg1Of or,support
R9523 T14538 T14536 arg2Of mutant,or
R9524 T14538 T14537 arg1Of mutant,a
R9525 T14538 T14539 arg1Of mutant,lacking
R9526 T14543 T14541 arg1Of domain,the
R9527 T14543 T14542 arg1Of domain,PH
R9528 T14543 T14544 arg1Of domain,and
R9529 T14544 T14539 arg2Of and,lacking
R9530 T14544 T14540 arg1Of and,both
R9531 T14547 T14544 arg2Of tag,and
R9532 T14547 T14545 arg1Of tag,the
R9533 T14547 T14546 arg1Of tag,Myr
R9534 T14550 T14548 arg2Of support,did
R9535 T14550 T14549 arg1Of support,not
R9536 T14550 T14560 arg1Of support,following
R9537 T14552 T14550 arg2Of activation,support
R9538 T14552 T14551 arg1Of activation,the
R9539 T14552 T14553 arg1Of activation,of
R9540 T14555 T14554 arg1Of death,cell
R9541 T14555 T14556 arg1Of death,or
R9542 T14556 T14553 arg2Of or,of
R9543 T14559 T14556 arg2Of phosphorylation,or
R9544 T14559 T14557 arg2Of phosphorylation,increased
R9545 T14559 T14558 arg1Of phosphorylation,Thr308
R9546 T14562 T14560 arg2Of addition,following
R9547 T14562 T14561 arg1Of addition,zVAD.fmk
R9548 T14562 T14563 arg1Of addition,under
R9549 T14566 T14563 arg2Of conditions,under
R9550 T14566 T14564 arg1Of conditions,serum
R9551 T14566 T14565 arg1Of conditions,free
R9552 T14566 T14567 arg1Of conditions,(
R9553 T14569 T14567 arg2Of S8A,(
R9554 T14569 T14568 arg1Of S8A,Fig.
R9555 T14569 T14570 arg1Of S8A,","
R9556 T14571 T14570 arg2Of B,","
R9557 T14572 T14567 arg3Of ),(
R9558 T14575 T14576 arg1Of we,found
R9559 T14578 T14579 arg1Of specific,and
R9560 T14580 T14579 arg2Of critical,and
R9561 T14581 T14577 arg1Of role,a
R9562 T14581 T14578 arg1Of role,specific
R9563 T14581 T14580 arg1Of role,critical
R9564 T14581 T14582 arg1Of role,for
R9565 T14581 T14585 arg1Of role,in
R9566 T14581 T14595 arg1Of role,has
R9567 T14581 T14596 arg1Of role,been
R9568 T14581 T14597 arg2Of role,reported
R9569 T14584 T14582 arg2Of phosphorylation,for
R9570 T14584 T14583 arg1Of phosphorylation,Thr308
R9571 T14587 T14585 arg2Of regulation,in
R9572 T14587 T14586 arg1Of regulation,the
R9573 T14587 T14588 arg1Of regulation,of
R9574 T14591 T14588 arg2Of functions,of
R9575 T14591 T14589 arg1Of functions,the
R9576 T14591 T14590 arg1Of functions,necroptotic
R9577 T14591 T14592 arg1Of functions,of
R9578 T14594 T14592 arg2Of It,of
R9579 T14594 T14593 arg1Of It,Akt.
R9580 T14597 T14573 arg1Of reported,Second
R9581 T14597 T14574 arg1Of reported,","
R9582 T14597 T14576 arg2Of reported,found
R9583 T14597 T14595 arg2Of reported,has
R9584 T14597 T14596 arg2Of reported,been
R9585 T14600 T14599 arg1Of mutations,Ala
R9586 T14600 T14601 arg1Of mutations,at
R9587 T14600 T14605 arg1Of mutations,cause
R9588 T14602 T14603 arg1Of Thr308,and
R9589 T14603 T14601 arg2Of and,at
R9590 T14604 T14603 arg2Of Ser473,and
R9591 T14605 T14597 arg3Of cause,reported
R9592 T14605 T14598 arg1Of cause,that
R9593 T14605 T14614 arg1Of cause,","
R9594 T14605 T14615 arg1Of cause,while
R9595 T14607 T14605 arg2Of reduction,cause
R9596 T14607 T14606 arg1Of reduction,a
R9597 T14607 T14608 arg1Of reduction,in
R9598 T14611 T14608 arg2Of activity,in
R9599 T14611 T14609 arg1Of activity,the
R9600 T14611 T14610 arg1Of activity,catalytic
R9601 T14611 T14612 arg1Of activity,of
R9602 T14613 T14612 arg2Of Akt,of
R9603 T14617 T14616 arg1Of mutants,Asp
R9604 T14617 T14618 arg1Of mutants,increase
R9605 T14618 T14615 arg2Of increase,while
R9606 T14619 T14618 arg2Of activity,increase
R9607 T14619 T14620 arg1Of activity,[
R9608 T14621 T14620 arg2Of 38,[
R9609 T14622 T14620 arg3Of ],[
R9610 T14623 T14624 arg1Of We,examined
R9611 T14626 T14624 arg2Of effect,examined
R9612 T14626 T14625 arg1Of effect,the
R9613 T14626 T14627 arg1Of effect,of
R9614 T14626 T14632 arg1Of effect,at
R9615 T14628 T14629 arg1Of Ala,and
R9616 T14630 T14629 arg2Of Asp,and
R9617 T14631 T14627 arg2Of mutants,of
R9618 T14631 T14628 arg1Of mutants,Ala
R9619 T14631 T14630 arg1Of mutants,Asp
R9620 T14634 T14632 arg2Of sites,at
R9621 T14634 T14633 arg1Of sites,both
R9622 T14634 T14635 arg1Of sites,during
R9623 T14636 T14635 arg2Of necroptosis,during
R9624 T14639 T14637 arg2Of hands,In
R9625 T14639 T14638 arg1Of hands,our
R9626 T14643 T14641 arg1Of mutants,both
R9627 T14643 T14642 arg1Of mutants,Asp
R9628 T14643 T14644 arg1Of mutants,displayed
R9629 T14644 T14637 arg1Of displayed,In
R9630 T14644 T14640 arg1Of displayed,","
R9631 T14644 T14651 arg1Of displayed,","
R9632 T14644 T14652 arg1Of displayed,while
R9633 T14645 T14644 arg2Of activity,displayed
R9634 T14645 T14646 arg1Of activity,comparable
R9635 T14646 T14647 arg1Of comparable,to
R9636 T14650 T14647 arg2Of Akt,to
R9637 T14650 T14648 arg1Of Akt,wild
R9638 T14650 T14649 arg1Of Akt,type
R9639 T14655 T14653 arg1Of mutants,both
R9640 T14655 T14654 arg1Of mutants,Ala
R9641 T14655 T14656 arg1Of mutants,displayed
R9642 T14656 T14652 arg2Of displayed,while
R9643 T14658 T14656 arg2Of decreases,displayed
R9644 T14658 T14657 arg1Of decreases,comparable
R9645 T14658 T14659 arg1Of decreases,in
R9646 T14660 T14659 arg2Of activity,in
R9647 T14660 T14661 arg1Of activity,(
R9648 T14663 T14661 arg2Of S8C,(
R9649 T14663 T14662 arg1Of S8C,Fig.
R9650 T14664 T14661 arg3Of ),(
R9651 T14668 T14665 arg2Of activities,Despite
R9652 T14668 T14666 arg1Of activities,similar
R9653 T14668 T14667 arg1Of activities,catalytic
R9654 T14670 T14671 arg1Of Thr308,and
R9655 T14672 T14671 arg2Of Ser473,and
R9656 T14673 T14670 arg1Of mutants,Thr308
R9657 T14673 T14672 arg1Of mutants,Ser473
R9658 T14673 T14674 arg1Of mutants,displayed
R9659 T14674 T14665 arg1Of displayed,Despite
R9660 T14674 T14669 arg1Of displayed,","
R9661 T14674 T14677 arg1Of displayed,in
R9662 T14676 T14674 arg2Of differences,displayed
R9663 T14676 T14675 arg1Of differences,major
R9664 T14679 T14677 arg2Of ability,in
R9665 T14679 T14678 arg1Of ability,their
R9666 T14679 T14680 modOf ability,to
R9667 T14681 T14680 arg1Of promote,to
R9668 T14683 T14681 arg2Of changes,promote
R9669 T14683 T14682 arg1Of changes,necroptotic
R9670 T14683 T14684 arg1Of changes,(
R9671 T14686 T14684 arg2Of 7E,(
R9672 T14686 T14685 arg1Of 7E,Fig.
R9673 T14686 T14687 arg1Of 7E,","
R9674 T14686 T14689 arg1Of 7E,","
R9675 T14688 T14687 arg2Of F,","
R9676 T14690 T14689 arg2Of G,","
R9677 T14691 T14684 arg3Of ),(
R9678 T14693 T14692 arg2Of expected,As
R9679 T14697 T14695 arg1Of mutant,the
R9680 T14697 T14696 arg1Of mutant,S473D
R9681 T14697 T14698 arg1Of mutant,","
R9682 T14697 T14699 arg1Of mutant,which
R9683 T14697 T14700 arg1Of mutant,was
R9684 T14697 T14701 arg2Of mutant,phosphorylated
R9685 T14697 T14710 arg1Of mutant,displayed
R9686 T14701 T14700 arg2Of phosphorylated,was
R9687 T14701 T14702 arg1Of phosphorylated,on
R9688 T14701 T14704 arg1Of phosphorylated,after
R9689 T14703 T14702 arg2Of Thr308,on
R9690 T14706 T14704 arg2Of addition,after
R9691 T14706 T14705 arg1Of addition,the
R9692 T14706 T14707 arg1Of addition,of
R9693 T14708 T14707 arg2Of zVAD,of
R9694 T14710 T14692 arg1Of displayed,As
R9695 T14710 T14694 arg1Of displayed,","
R9696 T14710 T14709 arg1Of displayed,","
R9697 T14710 T14715 arg1Of displayed,","
R9698 T14710 T14716 arg1Of displayed,while
R9699 T14712 T14711 arg1Of slightly,only
R9700 T14713 T14712 arg1Of reduced,slightly
R9701 T14714 T14710 arg2Of activity,displayed
R9702 T14714 T14713 arg1Of activity,reduced
R9703 T14717 T14718 arg1Of S473A,was
R9704 T14717 T14721 arg1Of S473A,active
R9705 T14718 T14716 arg2Of was,while
R9706 T14720 T14719 arg1Of less,significantly
R9707 T14721 T14718 arg2Of active,was
R9708 T14721 T14720 arg1Of active,less
R9709 T14721 T14722 arg1Of active,in
R9710 T14724 T14722 arg2Of aspects,in
R9711 T14724 T14723 arg1Of aspects,all
R9712 T14724 T14725 arg1Of aspects,of
R9713 T14726 T14725 arg2Of necroptosis,of
R9714 T14727 T14728 arg1Of S473A,was
R9715 T14727 T14729 arg1Of S473A,unable
R9716 T14727 T14731 arg1Of S473A,be
R9717 T14727 T14733 arg2Of S473A,phosphorylated
R9718 T14727 T14751 arg1Of S473A,provide
R9719 T14728 T14750 arg1Of was,and
R9720 T14729 T14728 arg2Of unable,was
R9721 T14729 T14738 arg1Of unable,to
R9722 T14733 T14729 arg2Of phosphorylated,unable
R9723 T14733 T14730 arg1Of phosphorylated,to
R9724 T14733 T14731 arg2Of phosphorylated,be
R9725 T14733 T14732 arg1Of phosphorylated,efficiently
R9726 T14733 T14734 arg1Of phosphorylated,on
R9727 T14733 T14736 arg1Of phosphorylated,possibly
R9728 T14735 T14734 arg2Of Thr308,on
R9729 T14738 T14737 arg1Of to,due
R9730 T14740 T14738 arg2Of inability,to
R9731 T14740 T14739 arg1Of inability,the
R9732 T14740 T14741 arg1Of inability,of
R9733 T14740 T14747 modOf inability,to
R9734 T14740 T14748 arg1Of inability,be
R9735 T14740 T14749 arg2Of inability,phosphorylated
R9736 T14746 T14741 arg2Of site,of
R9737 T14746 T14742 arg1Of site,the
R9738 T14746 T14743 arg1Of site,Ala
R9739 T14746 T14744 arg2Of site,mutated
R9740 T14746 T14745 arg1Of site,473
R9741 T14749 T14747 arg1Of phosphorylated,to
R9742 T14749 T14748 arg2Of phosphorylated,be
R9743 T14750 T14760 arg1Of and,[
R9744 T14751 T14750 arg2Of provide,and
R9745 T14754 T14751 arg2Of site,provide
R9746 T14754 T14752 arg1Of site,a
R9747 T14754 T14753 arg1Of site,docking
R9748 T14754 T14755 arg1Of site,for
R9749 T14756 T14755 arg2Of PDK1,for
R9750 T14756 T14758 arg1Of PDK1,phosphorylate
R9751 T14758 T14755 arg3Of phosphorylate,for
R9752 T14758 T14757 arg1Of phosphorylate,to
R9753 T14759 T14758 arg2Of Thr308,phosphorylate
R9754 T14761 T14760 arg2Of 39,[
R9755 T14762 T14760 arg3Of ],[
R9756 T14766 T14767 arg1Of Ala,and
R9757 T14767 T14765 arg1Of and,both
R9758 T14767 T14772 arg1Of and,were
R9759 T14767 T14775 arg1Of and,active
R9760 T14767 T14777 arg1Of and,promoting
R9761 T14769 T14767 arg2Of mutants,and
R9762 T14769 T14768 arg1Of mutants,Asp
R9763 T14769 T14770 arg1Of mutants,of
R9764 T14771 T14770 arg2Of Thr308,of
R9765 T14772 T14763 arg1Of were,Strikingly
R9766 T14772 T14764 arg1Of were,","
R9767 T14774 T14773 arg1Of less,significantly
R9768 T14775 T14772 arg2Of active,were
R9769 T14775 T14774 arg1Of active,less
R9770 T14775 T14776 arg1Of active,in
R9771 T14777 T14776 arg2Of promoting,in
R9772 T14779 T14778 arg1Of death,cell
R9773 T14779 T14780 arg1Of death,","
R9774 T14780 T14784 arg1Of ",",and
R9775 T14781 T14780 arg2Of phosphorylation,","
R9776 T14781 T14782 arg1Of phosphorylation,of
R9777 T14783 T14782 arg2Of JNK,of
R9778 T14784 T14787 arg1Of and,and
R9779 T14785 T14784 arg2Of c-Jun,and
R9780 T14787 T14777 arg2Of and,promoting
R9781 T14787 T14786 arg1Of and,","
R9782 T14789 T14787 arg2Of mRNA,and
R9783 T14789 T14788 arg1Of mRNA,TNFα
R9784 T14790 T14791 arg1Of This,suggests
R9785 T14793 T14804 arg1Of T308D,may
R9786 T14793 T14806 arg1Of T308D,be
R9787 T14796 T14795 arg2Of spite,in
R9788 T14796 T14797 arg1Of spite,of
R9789 T14798 T14797 arg2Of being,of
R9790 T14802 T14798 arg2Of construct,being
R9791 T14802 T14799 arg1Of construct,an
R9792 T14802 T14800 arg1Of construct,active
R9793 T14802 T14801 arg1Of construct,Akt
R9794 T14806 T14794 arg1Of be,","
R9795 T14806 T14795 arg1Of be,in
R9796 T14806 T14803 arg1Of be,","
R9797 T14806 T14804 arg2Of be,may
R9798 T14806 T14805 arg1Of be,not
R9799 T14806 T14812 arg1Of be,and
R9800 T14809 T14806 arg2Of mimic,be
R9801 T14809 T14807 arg1Of mimic,a
R9802 T14809 T14808 arg1Of mimic,perfect
R9803 T14809 T14810 arg1Of mimic,of
R9804 T14811 T14810 arg2Of phosphorylation,of
R9805 T14812 T14791 arg2Of and,suggests
R9806 T14812 T14792 arg1Of and,that
R9807 T14815 T14813 arg1Of form,this
R9808 T14815 T14814 arg1Of form,mutant
R9809 T14815 T14816 arg1Of form,of
R9810 T14815 T14819 arg1Of form,may
R9811 T14815 T14821 arg1Of form,have
R9812 T14818 T14816 arg2Of kinase,of
R9813 T14818 T14817 arg1Of kinase,the
R9814 T14821 T14812 arg2Of have,and
R9815 T14821 T14819 arg2Of have,may
R9816 T14821 T14820 arg1Of have,not
R9817 T14821 T14824 modOf have,to
R9818 T14823 T14821 arg2Of activity,have
R9819 T14823 T14822 arg1Of activity,sufficient
R9820 T14825 T14824 arg1Of phosphorylate,to
R9821 T14828 T14825 arg2Of repertoire,phosphorylate
R9822 T14828 T14826 arg1Of repertoire,the
R9823 T14828 T14827 arg1Of repertoire,entire
R9824 T14828 T14829 arg1Of repertoire,of
R9825 T14828 T14831 arg1Of repertoire,in
R9826 T14830 T14829 arg2Of substrates,of
R9827 T14833 T14831 arg2Of cells,in
R9828 T14833 T14832 arg1Of cells,the
R9829 T14835 T14834 arg2Of tested,When
R9830 T14837 T14838 arg1Of T308D,did
R9831 T14837 T14840 arg1Of T308D,support
R9832 T14840 T14834 arg1Of support,When
R9833 T14840 T14836 arg1Of support,","
R9834 T14840 T14838 arg2Of support,did
R9835 T14840 T14839 arg1Of support,not
R9836 T14843 T14840 arg2Of phosphorylation,support
R9837 T14843 T14841 arg1Of phosphorylation,the
R9838 T14843 T14842 arg1Of phosphorylation,downstream
R9839 T14843 T14844 arg1Of phosphorylation,of
R9840 T14846 T14844 arg2Of substrates,of
R9841 T14846 T14845 arg1Of substrates,several
R9842 T14846 T14847 arg1Of substrates,that
R9843 T14846 T14848 arg1Of substrates,were
R9844 T14846 T14849 arg2Of substrates,phosphorylated
R9845 T14849 T14848 arg2Of phosphorylated,were
R9846 T14853 T14849 arg1Of construct,phosphorylated
R9847 T14853 T14850 arg2Of construct,by
R9848 T14853 T14851 arg1Of construct,the
R9849 T14853 T14852 arg1Of construct,Myr-Akt
R9850 T14853 T14854 arg1Of construct,in
R9851 T14856 T14854 arg2Of presence,in
R9852 T14856 T14855 arg1Of presence,the
R9853 T14856 T14857 arg1Of presence,of
R9854 T14858 T14857 arg2Of zVAD,of
R9855 T14858 T14859 arg1Of zVAD,including
R9856 T14860 T14861 arg1Of FoxO1,","
R9857 T14861 T14863 arg1Of ",",","
R9858 T14862 T14861 arg2Of Foxo4,","
R9859 T14863 T14866 arg1Of ",",and
R9860 T14864 T14863 arg2Of MDM2,","
R9861 T14866 T14859 arg2Of and,including
R9862 T14866 T14865 arg1Of and,","
R9863 T14867 T14866 arg2Of p70S6K,and
R9864 T14867 T14868 arg1Of p70S6K,(
R9865 T14870 T14868 arg2Of S8D,(
R9866 T14870 T14869 arg1Of S8D,Fig.
R9867 T14871 T14868 arg3Of ),(
R9868 T14873 T14872 arg1Of model,Our
R9869 T14873 T14874 arg1Of model,","
R9870 T14873 T14875 arg1Of model,based
R9871 T14873 T14880 arg1Of model,is
R9872 T14876 T14875 arg2Of on,based
R9873 T14878 T14876 arg2Of results,on
R9874 T14878 T14877 arg1Of results,these
R9875 T14880 T14879 arg1Of is,","
R9876 T14884 T14882 arg1Of phosphorylation,necroptosis-specific
R9877 T14884 T14883 arg1Of phosphorylation,Thr308
R9878 T14884 T14885 arg1Of phosphorylation,provides
R9879 T14884 T14904 arg1Of phosphorylation,promote
R9880 T14885 T14895 arg1Of provides,","
R9881 T14885 T14896 modOf provides,allowing
R9882 T14885 T14903 arg1Of provides,","
R9883 T14888 T14885 arg2Of link,provides
R9884 T14888 T14886 arg1Of link,a
R9885 T14888 T14887 arg1Of link,critical
R9886 T14888 T14889 arg1Of link,between
R9887 T14891 T14890 arg1Of machinery,necroptotic
R9888 T14891 T14892 arg1Of machinery,and
R9889 T14892 T14889 arg2Of and,between
R9890 T14894 T14892 arg2Of kinase,and
R9891 T14894 T14893 arg1Of kinase,Akt
R9892 T14897 T14896 arg2Of Akt,allowing
R9893 T14897 T14899 arg1Of Akt,phosphorylate
R9894 T14899 T14896 arg3Of phosphorylate,allowing
R9895 T14899 T14898 arg1Of phosphorylate,to
R9896 T14899 T14901 arg1Of phosphorylate,during
R9897 T14900 T14899 arg2Of substrates,phosphorylate
R9898 T14902 T14901 arg2Of necroptosis,during
R9899 T14903 T14880 arg2Of ",",is
R9900 T14903 T14881 arg1Of ",",that
R9901 T14904 T14903 arg2Of promote,","
R9902 T14906 T14905 arg1Of synthesis,TNFα
R9903 T14906 T14907 arg1Of synthesis,","
R9904 T14907 T14910 arg1Of ",",and
R9905 T14909 T14907 arg2Of activation,","
R9906 T14909 T14908 arg1Of activation,JNK
R9907 T14910 T14904 arg2Of and,promote
R9908 T14913 T14910 arg2Of death,and
R9909 T14913 T14911 arg1Of death,eventual
R9910 T14913 T14912 arg1Of death,cell
R21541 T31215 T31214 arg1Of expression,Over
R21542 T31215 T31216 arg1Of expression,of
R21543 T31215 T31220 arg1Of expression,restores
R21544 T31218 T31217 arg1Of active,constitutively
R21545 T31219 T31216 arg2Of Akt,of
R21546 T31219 T31218 arg1Of Akt,active
R21547 T31220 T31222 arg1Of restores,under
R21548 T31221 T31220 arg2Of necroptosis,restores
R21549 T31225 T31222 arg2Of conditions,under
R21550 T31225 T31223 arg1Of conditions,serum
R21551 T31225 T31224 arg1Of conditions,free
R21552 T31227 T31226 arg2Of A,(
R21553 T31227 T31228 arg1Of A,","
R21554 T31229 T31228 arg2Of B,","
R21555 T31230 T31226 arg3Of ),(
R21556 T31232 T31226 arg1Of cells,(
R21557 T31232 T31231 arg1Of cells,L929
R21558 T31232 T31233 arg1Of cells,were
R21559 T31232 T31235 arg2Of cells,infected
R21560 T31235 T31233 arg2Of infected,were
R21561 T31235 T31234 arg1Of infected,stably
R21562 T31235 T31236 arg1Of infected,with
R21563 T31239 T31237 arg1Of retrovirus,empty
R21564 T31239 T31238 arg1Of retrovirus,MSCV
R21565 T31239 T31240 arg1Of retrovirus,or
R21566 T31240 T31236 arg2Of or,with
R21567 T31241 T31240 arg2Of viruses,or
R21568 T31241 T31242 arg1Of viruses,encoding
R21569 T31243 T31244 arg1Of Myr-Akt,or
R21570 T31244 T31242 arg2Of or,encoding
R21571 T31249 T31244 arg2Of K179M,or
R21572 T31249 T31245 arg1Of K179M,the
R21573 T31249 T31246 arg1Of K179M,catalytically
R21574 T31249 T31247 arg1Of K179M,inactive
R21575 T31249 T31248 arg1Of K179M,Myr-Akt
R21576 T31250 T31251 arg1Of Necroptosis,was
R21577 T31250 T31252 arg2Of Necroptosis,induced
R21578 T31252 T31251 arg2Of induced,was
R21579 T31255 T31254 arg1Of addition,the
R21580 T31255 T31256 arg1Of addition,of
R21581 T31255 T31258 arg1Of addition,under
R21582 T31255 T31265 arg1Of addition,or
R21583 T31257 T31256 arg2Of zVAD.fmk,of
R21584 T31261 T31258 arg2Of conditions,under
R21585 T31261 T31259 arg1Of conditions,serum
R21586 T31261 T31260 arg1Of conditions,free
R21587 T31261 T31262 arg1Of conditions,(
R21588 T31263 T31262 arg2Of A,(
R21589 T31264 T31262 arg3Of ),(
R21590 T31265 T31252 arg1Of or,induced
R21591 T31265 T31253 arg2Of or,by
R21592 T31266 T31267 arg1Of serum,or
R21593 T31267 T31265 arg2Of or,or
R21594 T31267 T31271 arg1Of or,with
R21595 T31270 T31267 arg2Of conditions,or
R21596 T31270 T31268 arg1Of conditions,serum
R21597 T31270 T31269 arg1Of conditions,free
R21598 T31272 T31271 arg2Of Nec-1,with
R21599 T31272 T31273 arg1Of Nec-1,(
R21600 T31274 T31273 arg2Of B,(
R21601 T31275 T31273 arg3Of ),(
R21602 T31277 T31276 arg1Of assays,Viability
R21603 T31277 T31278 arg1Of assays,were
R21604 T31277 T31279 arg2Of assays,performed
R21605 T31279 T31278 arg2Of performed,were
R21606 T31279 T31280 arg1Of performed,after
R21607 T31282 T31280 arg2Of hr.,after
R21608 T31282 T31281 arg1Of hr.,24
R21609 T31282 T31283 arg1Of hr.,(
R21610 T31282 T31291 modOf hr.,were
R21611 T31284 T31283 arg2Of C,(
R21612 T31285 T31283 arg3Of ),(
R21613 T31286 T31287 arg1Of Myr-Akt,and
R21614 T31287 T31291 arg1Of and,were
R21615 T31287 T31292 arg2Of and,treated
R21616 T31290 T31287 arg2Of cells,and
R21617 T31290 T31288 arg1Of cells,Myr-Akt
R21618 T31290 T31289 arg1Of cells,K179M
R21619 T31292 T31291 arg2Of treated,were
R21620 T31292 T31293 arg1Of treated,with
R21621 T31292 T31297 arg1Of treated,under
R21622 T31292 T31301 arg1Of treated,for
R21623 T31292 T31304 arg1Of treated,","
R21624 T31292 T31305 modOf treated,followed
R21625 T31294 T31295 arg1Of zVAD.fmk,and/or
R21626 T31295 T31293 arg2Of and/or,with
R21627 T31296 T31295 arg2Of Nec-1,and/or
R21628 T31300 T31297 arg2Of conditions,under
R21629 T31300 T31298 arg1Of conditions,serum
R21630 T31300 T31299 arg1Of conditions,free
R21631 T31303 T31301 arg2Of hr,for
R21632 T31303 T31302 arg1Of hr,9
R21633 T31308 T31305 arg1Of blot,followed
R21634 T31308 T31306 arg2Of blot,by
R21635 T31308 T31307 arg1Of blot,western
R21636 T31308 T31309 arg1Of blot,using
R21637 T31312 T31309 arg2Of antibodies,using
R21638 T31312 T31310 arg1Of antibodies,the
R21639 T31312 T31311 arg1Of antibodies,indicated
R21640 T31314 T31313 arg1Of Akt,Endogenous
R21641 T31314 T31315 arg1Of Akt,(
R21642 T31314 T31318 arg1Of Akt,and
R21643 T31316 T31315 arg2Of ∼,(
R21644 T31317 T31315 arg3Of ),(
R21645 T31318 T31324 modOf and,are
R21646 T31318 T31340 arg1Of and,were
R21647 T31318 T31341 arg2Of and,stimulated
R21648 T31319 T31318 arg2Of Myr-Akt,and
R21649 T31319 T31320 arg1Of Myr-Akt,(
R21650 T31321 T31320 arg2Of *,(
R21651 T31322 T31320 arg3Of ),(
R21652 T31323 T31324 arg1Of bands,are
R21653 T31323 T31325 arg2Of bands,indicated.
R21654 T31325 T31324 arg2Of indicated.,are
R21655 T31327 T31326 arg2Of D,(
R21656 T31328 T31326 arg3Of ),(
R21657 T31330 T31325 arg3Of cells,indicated.
R21658 T31330 T31326 arg1Of cells,(
R21659 T31330 T31329 arg1Of cells,L929
R21660 T31330 T31331 arg1Of cells,","
R21661 T31330 T31333 arg2Of cells,infected
R21662 T31333 T31332 arg1Of infected,stably
R21663 T31333 T31334 arg1Of infected,with
R21664 T31335 T31336 arg1Of Myr-Akt,and
R21665 T31336 T31334 arg2Of and,with
R21666 T31338 T31336 arg2Of K179KM,and
R21667 T31338 T31337 arg1Of K179KM,Myr-Akt
R21668 T31341 T31339 arg1Of stimulated,","
R21669 T31341 T31340 arg2Of stimulated,were
R21670 T31341 T31342 arg1Of stimulated,with
R21671 T31341 T31344 arg1Of stimulated,for
R21672 T31341 T31347 arg1Of stimulated,under
R21673 T31343 T31342 arg2Of zVAD.fmk,with
R21674 T31346 T31344 arg2Of hr,for
R21675 T31346 T31345 arg1Of hr,9
R21676 T31350 T31347 arg2Of conditions,under
R21677 T31350 T31348 arg1Of conditions,serum
R21678 T31350 T31349 arg1Of conditions,free
R21679 T31353 T31351 arg1Of levels,TNFα
R21680 T31353 T31352 arg1Of levels,mRNA
R21681 T31353 T31354 arg1Of levels,were
R21682 T31353 T31355 arg2Of levels,determined
R21683 T31353 T31359 arg2Of levels,normalized
R21684 T31353 T31360 arg1Of levels,using
R21685 T31355 T31356 arg1Of determined,by
R21686 T31355 T31358 arg1Of determined,and
R21687 T31357 T31356 arg2Of qRT-PCR,by
R21688 T31358 T31354 arg2Of and,were
R21689 T31359 T31358 arg2Of normalized,and
R21690 T31360 T31359 arg3Of using,normalized
R21691 T31360 T31415 arg1Of using,by
R21692 T31363 T31361 arg1Of RNA.,mouse
R21693 T31363 T31362 arg1Of RNA.,18S
R21694 T31363 T31364 arg1Of RNA.,(
R21695 T31363 T31380 modOf RNA.,were
R21696 T31363 T31399 arg1Of RNA.,","
R21697 T31365 T31364 arg2Of E-G,(
R21698 T31366 T31364 arg3Of ),(
R21699 T31368 T31367 arg1Of cells,L929
R21700 T31368 T31369 arg1Of cells,expressing
R21701 T31368 T31380 arg1Of cells,were
R21702 T31368 T31381 arg2Of cells,treated
R21703 T31370 T31371 arg1Of Myr-Akt,and
R21704 T31371 T31373 arg1Of and,and
R21705 T31372 T31371 arg2Of Ala,and
R21706 T31373 T31369 arg2Of and,expressing
R21707 T31375 T31373 arg2Of mutants,and
R21708 T31375 T31374 arg1Of mutants,Asp
R21709 T31375 T31376 arg1Of mutants,of
R21710 T31377 T31378 arg1Of Thr308,and
R21711 T31378 T31376 arg2Of and,of
R21712 T31379 T31378 arg2Of Ser473,and
R21713 T31381 T31380 arg2Of treated,were
R21714 T31381 T31382 arg1Of treated,with
R21715 T31381 T31384 arg1Of treated,under
R21716 T31381 T31388 arg1Of treated,","
R21717 T31381 T31389 modOf treated,followed
R21718 T31383 T31382 arg2Of zVAD.fmk,with
R21719 T31387 T31384 arg2Of conditions,under
R21720 T31387 T31385 arg1Of conditions,serum
R21721 T31387 T31386 arg1Of conditions,free
R21722 T31392 T31389 arg1Of assay,followed
R21723 T31392 T31390 arg2Of assay,by
R21724 T31392 T31391 arg1Of assay,viability
R21725 T31392 T31393 arg1Of assay,at
R21726 T31395 T31393 arg2Of hr,at
R21727 T31395 T31394 arg1Of hr,24
R21728 T31395 T31396 arg1Of hr,(
R21729 T31397 T31396 arg2Of E,(
R21730 T31398 T31396 arg3Of ),(
R21731 T31399 T31409 arg1Of ",",or
R21732 T31401 T31399 arg2Of blot,","
R21733 T31401 T31400 arg1Of blot,western
R21734 T31401 T31402 arg1Of blot,at
R21735 T31404 T31402 arg2Of hr,at
R21736 T31404 T31403 arg1Of hr,9
R21737 T31404 T31405 arg1Of hr,(
R21738 T31406 T31405 arg2Of F,(
R21739 T31407 T31405 arg3Of ),(
R21740 T31409 T31360 arg2Of or,using
R21741 T31409 T31408 arg1Of or,","
R21742 T31410 T31409 arg2Of evaluation,or
R21743 T31410 T31411 arg1Of evaluation,of
R21744 T31414 T31411 arg2Of levels,of
R21745 T31414 T31412 arg1Of levels,TNFα
R21746 T31414 T31413 arg1Of levels,mRNA
R21747 T31416 T31415 arg2Of qRT-PCR,by
R21748 T31416 T31417 arg1Of qRT-PCR,at
R21749 T31419 T31417 arg2Of hrs,at
R21750 T31419 T31418 arg1Of hrs,9
R21751 T31419 T31420 arg1Of hrs,(
R21752 T31421 T31420 arg2Of G,(
R21753 T31422 T31420 arg3Of ),(
R21754 T31425 T31423 arg2Of graphs,In
R21755 T31425 T31424 arg1Of graphs,all
R21756 T31427 T31428 arg1Of average±SD,was
R21757 T31427 T31429 arg2Of average±SD,plotted
R21758 T31429 T31423 arg1Of plotted,In
R21759 T31429 T31426 arg1Of plotted,","
R21760 T31429 T31428 arg2Of plotted,was

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T13834 5033-5045 Antecedent denotes S473D mutant
T13833 5047-5052 Anaphor denotes which
T13832 4789-4793 Anaphor denotes both
T13831 4673-4683 Antecedent denotes both sites
T13830 4718-4722 Anaphor denotes both
R9039 T13830 T13831 boundBy both,both sites
R9040 T13832 T13831 boundBy both,both sites
R9041 T13833 T13834 boundBy which,S473D mutant

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T13877 6274-6278 Protein denotes TNFα
T13876 6028-6034 Protein denotes p70S6K
T13875 6018-6022 Protein denotes MDM2
T13874 6011-6016 Protein denotes Foxo4
T13873 6004-6009 Protein denotes FoxO1
T13872 5952-5959 Protein denotes Myr-Akt
T13871 5845-5850 Protein denotes T308D
T13870 5601-5606 Protein denotes T308D
T13869 5571-5575 Protein denotes TNFα
T13868 5560-5565 Protein denotes c-Jun
T13867 5395-5399 Protein denotes PDK1
T13866 5225-5230 Protein denotes S473A
T13865 5158-5163 Protein denotes S473A
T13864 5033-5045 Protein denotes S473D mutant
T13863 4577-4580 Protein denotes Akt
T13862 3969-3976 Protein denotes Myr-Akt
T13861 3915-3919 Protein denotes TNFα
T13860 3782-3789 Protein denotes Myr-Akt
T13859 3666-3670 Protein denotes MDM2
T13858 3656-3661 Protein denotes FoxO1
T13857 3552-3557 Protein denotes FoxO4
T13856 3538-3540 Protein denotes S6
T13855 3530-3536 Protein denotes p70S6K
T13854 3494-3501 Protein denotes Myr-Akt
T13853 3302-3307 Protein denotes K179M
T13852 3281-3288 Protein denotes Myr-Akt
T13851 3127-3134 Protein denotes Myr-Akt
T13850 3090-3097 Protein denotes Myr-Akt
T13848 1755-1759 Protein denotes RIP1
T13847 1646-1650 Protein denotes RIP1
T13846 1344-1348 Protein denotes TNFα
T13845 1292-1297 Protein denotes c-Jun
T13844 1088-1095 Protein denotes Myr-Akt
T13843 996-1001 Protein denotes K179M
T13842 975-982 Protein denotes Myr-Akt
T13841 689-696 Protein denotes Myr-Akt
T13840 364-371 Protein denotes Myr-Akt
T13839 358-362 Protein denotes Akt1
T13838 286-290 Protein denotes RIP1
T13837 210-215 Protein denotes K179M
T13836 164-171 Protein denotes Myr-Akt
T13835 158-162 Protein denotes Akt1
T31196 2961-2965 Protein denotes TNFα
T31195 2730-2733 Protein denotes 18S
T31194 2659-2663 Protein denotes TNFα

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T31465 2961-2965 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T31464 2659-2663 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T31463 2771-2774 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31462 2579-2582 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31461 2567-2570 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31460 2497-2500 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31459 2481-2484 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31458 2319-2322 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31457 2307-2310 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31456 2109-2112 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31455 2071-2074 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31454 1928-1931 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T31453 2771-2774 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31452 2579-2582 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31451 2567-2570 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31450 2497-2500 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31449 2481-2484 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31448 2319-2322 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31447 2307-2310 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31446 2109-2112 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31445 2071-2074 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31444 1928-1931 http://www.uniprot.org/uniprot/P31751 denotes Akt
T31443 2771-2774 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31442 2579-2582 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31441 2567-2570 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31440 2497-2500 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31439 2481-2484 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31438 2319-2322 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31437 2307-2310 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31436 2109-2112 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31435 2071-2074 http://www.uniprot.org/uniprot/P31749 denotes Akt
T31434 1928-1931 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15075 3352-3355 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15074 3285-3288 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15073 3229-3232 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15072 3170-3173 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15071 3131-3134 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15070 3094-3097 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15069 1811-1814 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15068 1685-1688 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15067 1582-1585 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15066 1552-1555 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15065 1435-1438 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15064 1210-1213 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15063 1166-1169 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15062 1092-1095 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15061 979-982 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15060 885-888 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15055 168-171 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15054 36-39 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15053 6214-6217 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15052 6193-6196 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15051 5956-5959 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15050 5636-5639 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15049 4778-4781 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15048 4577-4580 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15047 4464-4467 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15046 4131-4134 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15045 4102-4105 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15044 4026-4029 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15043 3973-3976 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15042 3786-3789 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15041 3498-3501 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15040 3352-3355 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15039 3285-3288 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15038 3229-3232 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15037 3170-3173 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15036 3131-3134 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15035 3094-3097 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15034 1811-1814 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15033 1685-1688 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15032 1582-1585 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15031 1552-1555 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15030 1435-1438 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15029 1210-1213 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15028 1166-1169 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15027 1092-1095 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15026 979-982 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15025 885-888 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15024 693-696 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15023 602-605 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15022 368-371 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15021 301-304 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15020 168-171 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15019 36-39 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15018 6214-6217 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15017 6193-6196 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15016 5956-5959 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15015 5636-5639 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15014 4778-4781 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15013 4577-4580 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15012 4464-4467 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15011 4131-4134 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15010 4102-4105 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15009 4026-4029 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15008 3973-3976 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15007 3786-3789 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15006 3498-3501 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15005 3352-3355 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15004 3285-3288 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15003 3229-3232 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15002 3170-3173 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15001 3131-3134 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15000 3094-3097 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14999 1811-1814 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14998 1685-1688 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14997 1582-1585 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14996 1552-1555 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14995 1435-1438 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14994 1210-1213 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14993 1166-1169 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14992 1092-1095 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14991 979-982 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14990 885-888 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14989 693-696 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14988 602-605 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14987 368-371 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15100 6004-6009 http://www.uniprot.org/uniprot/Q12778 denotes FoxO1
T15099 3656-3661 http://www.uniprot.org/uniprot/Q12778 denotes FoxO1
T15098 6274-6278 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T15097 5571-5575 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T15096 3915-3919 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T15095 1344-1348 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T15094 5560-5565 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T15093 1292-1297 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T15091 1755-1759 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T15090 1646-1650 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T15089 286-290 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T15088 6214-6217 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15087 6193-6196 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15086 5956-5959 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15085 5636-5639 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15084 4778-4781 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15083 4577-4580 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15082 4464-4467 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15081 4131-4134 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15080 4102-4105 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15079 4026-4029 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15078 3973-3976 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15077 3786-3789 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15076 3498-3501 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T14986 301-304 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14985 168-171 http://www.uniprot.org/uniprot/P31749 denotes Akt
T14984 36-39 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15057 368-371 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15056 301-304 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15059 693-696 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15058 602-605 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt

UBERON-AE

Id Subject Object Predicate Lexical cue
T31183 2853-2858 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T31182 2636-2641 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T31181 2381-2386 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T31180 2216-2221 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T31179 2207-2212 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T31178 2178-2183 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T31177 1959-1964 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13695 4305-4310 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13694 3825-3830 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13693 1379-1384 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13692 953-958 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13691 830-835 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13690 627-632 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13689 67-72 http://purl.obolibrary.org/obo/UBERON_0001977 denotes Serum

GO-BP

Id Subject Object Predicate Lexical cue
T31200 2120-2131 http://purl.obolibrary.org/obo/GO_0097528 denotes Necroptosis
T31199 1941-1952 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T31198 2120-2131 http://purl.obolibrary.org/obo/GO_0070266 denotes Necroptosis
T31197 1941-1952 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13955 6279-6288 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T13954 5395-5399 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T13953 4877-4897 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activities
T13952 4555-4573 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T13951 4421-4431 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T13950 4398-4431 http://purl.obolibrary.org/obo/GO_0042325 denotes phosphorylation in the regulation
T13949 4210-4234 http://purl.obolibrary.org/obo/GO_1904094 denotes activation of cell death
T13948 4210-4234 http://purl.obolibrary.org/obo/GO_0043068 denotes activation of cell death
T13947 4210-4234 http://purl.obolibrary.org/obo/GO_0071888 denotes activation of cell death
T13946 4210-4234 http://purl.obolibrary.org/obo/GO_1901216 denotes activation of cell death
T13945 4210-4228 http://purl.obolibrary.org/obo/GO_0001775 denotes activation of cell
T13944 3542-3545 http://purl.obolibrary.org/obo/GO_0050321 denotes GSK
T13943 4077-4098 http://purl.obolibrary.org/obo/GO_0051668 denotes membrane localization
T13942 1533-1551 http://purl.obolibrary.org/obo/GO_0051668 denotes membrane localized
T13941 6290-6293 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13940 5552-5555 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13939 3899-3902 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13938 1284-1287 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13937 6118-6133 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13936 5882-5897 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13935 5681-5696 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13934 5533-5548 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13933 4398-4413 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13932 4255-4270 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13931 3763-3778 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13930 3637-3652 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13929 3424-3439 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13927 1298-1313 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13926 1177-1192 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13925 6323-6328 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13924 5526-5531 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13923 4229-4234 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13922 3892-3897 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13921 1111-1116 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13920 940-945 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13919 6318-6328 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13918 5521-5531 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13917 4224-4234 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13916 3887-3897 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13915 1106-1116 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13914 935-945 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13913 4086-4098 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T13912 487-499 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T13911 1635-1644 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T13910 1466-1475 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T13909 452-458 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T13908 1736-1742 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T13907 1621-1627 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T13906 267-273 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T13905 6253-6264 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13904 6090-6101 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13903 5212-5223 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13902 4691-4702 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13901 4043-4054 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13900 3105-3116 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13899 1830-1841 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13898 1707-1718 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13897 1604-1615 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13896 1125-1136 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13895 1042-1053 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13894 815-826 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13893 323-334 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13892 49-60 http://purl.obolibrary.org/obo/GO_0097528 denotes Necroptosis
T13891 6253-6264 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13890 6090-6101 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13889 5212-5223 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13888 4691-4702 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13887 4043-4054 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13886 3105-3116 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13885 1830-1841 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13884 1707-1718 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13883 1604-1615 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13882 1125-1136 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13881 1042-1053 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13880 815-826 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13879 323-334 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13878 49-60 http://purl.obolibrary.org/obo/GO_0070266 denotes Necroptosis

GO-MF

Id Subject Object Predicate Lexical cue
T13963 5395-5399 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T13962 4877-4897 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activities
T13961 4555-4573 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T13960 3542-3545 http://purl.obolibrary.org/obo/GO_0050321 denotes GSK
T13959 6290-6293 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13958 5552-5555 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13957 3899-3902 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13956 1284-1287 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T31201 2458-2468 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies

GO-CC

Id Subject Object Predicate Lexical cue
T31207 2458-2468 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T31206 2458-2468 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T31205 2750-2755 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T31204 2535-2540 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T31203 2329-2334 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T31202 1993-1998 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13974 1446-1450 http://purl.obolibrary.org/obo/GO_0097683 denotes apex
T13973 4077-4085 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T13972 1533-1541 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T13971 514-522 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T13970 507-522 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membrane
T13969 6318-6322 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13968 5825-5830 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13967 3375-3380 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13966 775-780 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13965 672-677 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13964 102-107 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T31190 3003-3041 Sentence denotes In all graphs, average±SD was plotted.
T31189 2659-3002 Sentence denotes TNFα mRNA levels were determined by qRT-PCR and normalized using mouse 18S RNA. (E-G) L929 cells expressing Myr-Akt and Ala and Asp mutants of Thr308 and Ser473 were treated with zVAD.fmk under serum free conditions, followed by viability assay at 24 hr (E), western blot at 9 hr (F), or evaluation of TNFα mRNA levels by qRT-PCR at 9 hrs (G).
T31188 2470-2658 Sentence denotes Endogenous Akt (∼) and Myr-Akt (*) bands are indicated. (D) L929 cells, stably infected with Myr-Akt and Myr-Akt K179KM, were stimulated with zVAD.fmk for 9 hr under serum free conditions.
T31187 2254-2469 Sentence denotes Viability assays were performed after 24 hr. (C) Myr-Akt and Myr-Akt K179M cells were treated with zVAD.fmk and/or Nec-1 under serum free conditions for 9 hr, followed by western blot using the indicated antibodies.
T31186 2120-2253 Sentence denotes Necroptosis was induced by the addition of zVAD.fmk under serum free conditions (A) or serum or serum free conditions with Nec-1 (B).
T31185 1982-2119 Sentence denotes (A,B) L929 cells were stably infected with empty MSCV retrovirus or viruses encoding Myr-Akt or the catalytically inactive Myr-Akt K179M.
T31184 1887-1981 Sentence denotes Over expression of constitutively active Akt restores necroptosis under serum free conditions.
T13722 6047-6329 Sentence denotes Our model, based on these results, is that necroptosis-specific Thr308 phosphorylation provides a critical link between necroptotic machinery and Akt kinase, allowing Akt to phosphorylate substrates during necroptosis, promote TNFα synthesis, JNK activation and eventual cell death.
T13721 5832-6046 Sentence denotes When tested, T308D did not support the downstream phosphorylation of several substrates that were phosphorylated by the Myr-Akt construct in the presence of zVAD including FoxO1, Foxo4, MDM2, and p70S6K (Fig. S8D).
T13720 5582-5831 Sentence denotes This suggests that T308D, in spite of being an active Akt construct, may not be a perfect mimic of phosphorylation and this mutant form of the kinase may not have sufficient activity to phosphorylate the entire repertoire of substrates in the cells.
T13719 5430-5581 Sentence denotes Strikingly, both Ala and Asp mutants of Thr308 were significantly less active in promoting cell death, phosphorylation of JNK and c-Jun, and TNFα mRNA.
T13718 5225-5429 Sentence denotes S473A was unable to be efficiently phosphorylated on Thr308 possibly due to the inability of the Ala mutated 473 site to be phosphorylated and provide a docking site for PDK1 to phosphorylate Thr308 [39].
T13717 5016-5224 Sentence denotes As expected, the S473D mutant, which was phosphorylated on Thr308 after the addition of zVAD, displayed only slightly reduced activity, while S473A was significantly less active in all aspects of necroptosis.
T13716 4861-5015 Sentence denotes Despite similar catalytic activities, Thr308 and Ser473 mutants displayed major differences in their ability to promote necroptotic changes (Fig. 7E,F,G).
T13715 4704-4860 Sentence denotes In our hands, both Asp mutants displayed activity comparable to wild type Akt, while both Ala mutants displayed comparable decreases in activity (Fig. S8C).
T13714 4624-4703 Sentence denotes We examined the effect of Ala and Asp mutants at both sites during necroptosis.
T13713 4341-4623 Sentence denotes Second, we found a specific and critical role for Thr308 phosphorylation in the regulation of the necroptotic functions of Akt. It has been reported that Ala mutations at Thr308 and Ser473 cause a reduction in the catalytic activity of Akt, while Asp mutants increase activity [38].
T13712 4119-4340 Sentence denotes Full length Akt or a mutant lacking both the PH domain and the Myr tag did not support the activation of cell death or increased Thr308 phosphorylation following zVAD.fmk addition under serum free conditions (Fig. S8A,B).
T13711 4056-4118 Sentence denotes First, we found that membrane localization of Akt is required.
T13710 3819-4055 Sentence denotes Under serum free conditions all zVAD.fmk-induced downstream events (cell death, JNK activation, TNFα production) were dependent on the over expressed Myr-Akt. This allowed us to examine the effects of other Akt mutations on necroptosis.
T13709 3618-3818 Sentence denotes On the other hand, phosphorylation of FoxO1 and MDM2 was significantly increased in the presence of zVAD.fmk, indicating that necroptotic Thr308 phosphorylation of Myr-Akt still promoted its activity.
T13708 3392-3617 Sentence denotes The effect of zVAD.fmk on their phosphorylation varied, likely due to the increased basal activity of Myr-Akt. Some substrates, including p70S6K, S6, GSK-3 and FoxO4, were fully phosphorylated even in the absence of zVAD.fmk.
T13707 3184-3391 Sentence denotes Phosphorylation of many previously described Akt substrates was increased upon the expression of Myr-Akt, but not the K179M mutant, confirming that these molecules are Akt substrates in L929 cells (Fig. 7C).
T13705 1646-1842 Sentence denotes RIP1 kinase was still able to regulate Akt activation during necroptosis, suggesting that growth factors and RIP1 kinase provide two independent inputs required for Akt changes during necroptosis.
T13704 1477-1645 Sentence denotes These data demonstrated that the presence of active and membrane localized Akt is sufficient to uncouple Akt activation during necroptosis from growth factor signaling.
T13703 1206-1476 Sentence denotes Myr-Akt also allowed other zVAD.fmk-dependent events, including activation of JNK and c-Jun phosphorylation (Fig. 7C) and upregulation of TNFα mRNA (Fig. 7D) to occur under serum free conditions, confirming an important role for Akt at the apex of necroptotic signaling.
T13702 1067-1205 Sentence denotes Nec-1 prevented both Myr-Akt dependent cell death and the necroptosis-specific delayed increase in Akt Thr308 phosphorylation (Fig. 7B,C).
T13701 947-1066 Sentence denotes Under serum free conditions Myr-Akt, but not the K179M mutant, fully restored zVAD.fmk-induced necroptosis (Fig. 7A,B).
T13700 858-946 Sentence denotes This indicates that active Akt alone is not sufficient to induce necroptotic cell death.
T13699 639-857 Sentence denotes It is important to note that the cells expressing Myr-Akt were viable, grew in a manner indistinguishable from the empty vector control cells, and were not triggered to induce necroptosis by serum starvation (Fig. 7B).
T13698 336-638 Sentence denotes Constitutively active Akt1 (Myr-Akt) was generated as previously described [37] by the addition of a myristoylation signal which provides constitutive localization to the plasma membrane and by the deletion of the auto-inhibitory PH domain (Fig. 7A) resulting in an Akt that is active under serum free.
T13697 89-335 Sentence denotes We used L929 cells stably expressing constitutively active wild type Akt1 (Myr-Akt) or the catalytically inactive mutant K179M in order to further understand the contribution of growth factors and RIP1 kinase to Akt activation during necroptosis.
T13696 0-88 Sentence denotes Expression of Constitutively Active Akt, Rescues Necroptosis Under Serum Free Conditions
T176 0-88 Sentence denotes Expression of Constitutively Active Akt, Rescues Necroptosis Under Serum Free Conditions
T177 89-335 Sentence denotes We used L929 cells stably expressing constitutively active wild type Akt1 (Myr-Akt) or the catalytically inactive mutant K179M in order to further understand the contribution of growth factors and RIP1 kinase to Akt activation during necroptosis.
T178 336-638 Sentence denotes Constitutively active Akt1 (Myr-Akt) was generated as previously described [37] by the addition of a myristoylation signal which provides constitutive localization to the plasma membrane and by the deletion of the auto-inhibitory PH domain (Fig. 7A) resulting in an Akt that is active under serum free.
T179 639-857 Sentence denotes It is important to note that the cells expressing Myr-Akt were viable, grew in a manner indistinguishable from the empty vector control cells, and were not triggered to induce necroptosis by serum starvation (Fig. 7B).
T180 858-946 Sentence denotes This indicates that active Akt alone is not sufficient to induce necroptotic cell death.
T181 947-1066 Sentence denotes Under serum free conditions Myr-Akt, but not the K179M mutant, fully restored zVAD.fmk-induced necroptosis (Fig. 7A,B).
T182 1067-1205 Sentence denotes Nec-1 prevented both Myr-Akt dependent cell death and the necroptosis-specific delayed increase in Akt Thr308 phosphorylation (Fig. 7B,C).
T183 1206-1476 Sentence denotes Myr-Akt also allowed other zVAD.fmk-dependent events, including activation of JNK and c-Jun phosphorylation (Fig. 7C) and upregulation of TNFα mRNA (Fig. 7D) to occur under serum free conditions, confirming an important role for Akt at the apex of necroptotic signaling.
T184 1477-1645 Sentence denotes These data demonstrated that the presence of active and membrane localized Akt is sufficient to uncouple Akt activation during necroptosis from growth factor signaling.
T185 1646-1842 Sentence denotes RIP1 kinase was still able to regulate Akt activation during necroptosis, suggesting that growth factors and RIP1 kinase provide two independent inputs required for Akt changes during necroptosis.
T186 1843-1981 Sentence denotes 10.1371/journal.pone.0056576.g007 Figure 7 Over expression of constitutively active Akt restores necroptosis under serum free conditions.
T187 1982-2119 Sentence denotes (A,B) L929 cells were stably infected with empty MSCV retrovirus or viruses encoding Myr-Akt or the catalytically inactive Myr-Akt K179M.
T188 2120-2253 Sentence denotes Necroptosis was induced by the addition of zVAD.fmk under serum free conditions (A) or serum or serum free conditions with Nec-1 (B).
T189 2254-2469 Sentence denotes Viability assays were performed after 24 hr. (C) Myr-Akt and Myr-Akt K179M cells were treated with zVAD.fmk and/or Nec-1 under serum free conditions for 9 hr, followed by western blot using the indicated antibodies.
T190 2470-2658 Sentence denotes Endogenous Akt (∼) and Myr-Akt (*) bands are indicated. (D) L929 cells, stably infected with Myr-Akt and Myr-Akt K179KM, were stimulated with zVAD.fmk for 9 hr under serum free conditions.
T191 2659-3002 Sentence denotes TNFα mRNA levels were determined by qRT-PCR and normalized using mouse 18S RNA. (E-G) L929 cells expressing Myr-Akt and Ala and Asp mutants of Thr308 and Ser473 were treated with zVAD.fmk under serum free conditions, followed by viability assay at 24 hr (E), western blot at 9 hr (F), or evaluation of TNFα mRNA levels by qRT-PCR at 9 hrs (G).
T192 3003-3041 Sentence denotes In all graphs, average±SD was plotted.
T193 3042-3183 Sentence denotes RIP1 kinase-dependent Thr308 phosphorylation of Myr-Akt during necroptosis increased Myr-Akt activity as it did with endogenous Akt (Fig. 5).
T194 3184-3391 Sentence denotes Phosphorylation of many previously described Akt substrates was increased upon the expression of Myr-Akt, but not the K179M mutant, confirming that these molecules are Akt substrates in L929 cells (Fig. 7C).
T195 3392-3502 Sentence denotes The effect of zVAD.fmk on their phosphorylation varied, likely due to the increased basal activity of Myr-Akt.
T196 3503-3617 Sentence denotes Some substrates, including p70S6K, S6, GSK-3 and FoxO4, were fully phosphorylated even in the absence of zVAD.fmk.
T197 3618-3818 Sentence denotes On the other hand, phosphorylation of FoxO1 and MDM2 was significantly increased in the presence of zVAD.fmk, indicating that necroptotic Thr308 phosphorylation of Myr-Akt still promoted its activity.
T198 3819-3977 Sentence denotes Under serum free conditions all zVAD.fmk-induced downstream events (cell death, JNK activation, TNFα production) were dependent on the over expressed Myr-Akt.
T199 3978-4055 Sentence denotes This allowed us to examine the effects of other Akt mutations on necroptosis.
T200 4056-4118 Sentence denotes First, we found that membrane localization of Akt is required.
T201 4119-4340 Sentence denotes Full length Akt or a mutant lacking both the PH domain and the Myr tag did not support the activation of cell death or increased Thr308 phosphorylation following zVAD.fmk addition under serum free conditions (Fig. S8A,B).
T202 4341-4468 Sentence denotes Second, we found a specific and critical role for Thr308 phosphorylation in the regulation of the necroptotic functions of Akt.
T203 4469-4623 Sentence denotes It has been reported that Ala mutations at Thr308 and Ser473 cause a reduction in the catalytic activity of Akt, while Asp mutants increase activity [38].
T204 4624-4703 Sentence denotes We examined the effect of Ala and Asp mutants at both sites during necroptosis.
T205 4704-4860 Sentence denotes In our hands, both Asp mutants displayed activity comparable to wild type Akt, while both Ala mutants displayed comparable decreases in activity (Fig. S8C).
T206 4861-5015 Sentence denotes Despite similar catalytic activities, Thr308 and Ser473 mutants displayed major differences in their ability to promote necroptotic changes (Fig. 7E,F,G).
T207 5016-5224 Sentence denotes As expected, the S473D mutant, which was phosphorylated on Thr308 after the addition of zVAD, displayed only slightly reduced activity, while S473A was significantly less active in all aspects of necroptosis.
T208 5225-5429 Sentence denotes S473A was unable to be efficiently phosphorylated on Thr308 possibly due to the inability of the Ala mutated 473 site to be phosphorylated and provide a docking site for PDK1 to phosphorylate Thr308 [39].
T209 5430-5581 Sentence denotes Strikingly, both Ala and Asp mutants of Thr308 were significantly less active in promoting cell death, phosphorylation of JNK and c-Jun, and TNFα mRNA.
T210 5582-5831 Sentence denotes This suggests that T308D, in spite of being an active Akt construct, may not be a perfect mimic of phosphorylation and this mutant form of the kinase may not have sufficient activity to phosphorylate the entire repertoire of substrates in the cells.
T211 5832-6046 Sentence denotes When tested, T308D did not support the downstream phosphorylation of several substrates that were phosphorylated by the Myr-Akt construct in the presence of zVAD including FoxO1, Foxo4, MDM2, and p70S6K (Fig. S8D).
T212 6047-6329 Sentence denotes Our model, based on these results, is that necroptosis-specific Thr308 phosphorylation provides a critical link between necroptotic machinery and Akt kinase, allowing Akt to phosphorylate substrates during necroptosis, promote TNFα synthesis, JNK activation and eventual cell death.

simple1

Id Subject Object Predicate Lexical cue
T31213 2961-2965 Protein denotes TNFα
T31212 2730-2733 Protein denotes 18S
T31211 2659-2663 Protein denotes TNFα
T14041 3656-3661 Protein denotes FoxO1
T14040 3552-3557 Protein denotes FoxO4
T14039 3538-3540 Protein denotes S6
T14038 3530-3536 Protein denotes p70S6K
T14037 3494-3501 Protein denotes Myr-Akt
T14036 3302-3307 Protein denotes K179M
T14035 3281-3288 Protein denotes Myr-Akt
T14034 3127-3134 Protein denotes Myr-Akt
T14033 3090-3097 Protein denotes Myr-Akt
T14031 1755-1759 Protein denotes RIP1
T14030 1646-1650 Protein denotes RIP1
T14029 1344-1348 Protein denotes TNFα
T14028 1292-1297 Protein denotes c-Jun
T14027 1088-1095 Protein denotes Myr-Akt
T14026 996-1001 Protein denotes K179M
T14025 975-982 Protein denotes Myr-Akt
T14024 689-696 Protein denotes Myr-Akt
T14023 364-371 Protein denotes Myr-Akt
T14022 358-362 Protein denotes Akt1
T14021 286-290 Protein denotes RIP1
T14020 210-215 Protein denotes K179M
T14019 164-171 Protein denotes Myr-Akt
T14018 158-162 Protein denotes Akt1
T14060 6274-6278 Protein denotes TNFα
T14059 6028-6034 Protein denotes p70S6K
T14058 6018-6022 Protein denotes MDM2
T14057 6011-6016 Protein denotes Foxo4
T14056 6004-6009 Protein denotes FoxO1
T14055 5952-5959 Protein denotes Myr-Akt
T14054 5845-5850 Protein denotes T308D
T14053 5601-5606 Protein denotes T308D
T14052 5571-5575 Protein denotes TNFα
T14051 5560-5565 Protein denotes c-Jun
T14050 5395-5399 Protein denotes PDK1
T14049 5225-5230 Protein denotes S473A
T14048 5158-5163 Protein denotes S473A
T14047 5033-5045 Protein denotes S473D mutant
T14046 4577-4580 Protein denotes Akt
T14045 3969-3976 Protein denotes Myr-Akt
T14044 3915-3919 Protein denotes TNFα
T14043 3782-3789 Protein denotes Myr-Akt
T14042 3666-3670 Protein denotes MDM2

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T31433 2669-2675 Transcription denotes levels
T31432 2961-2965 Protein denotes TNFα
T31431 2730-2733 Protein denotes 18S
T31430 2659-2663 Protein denotes TNFα
T14983 6279-6288 Gene_expression denotes synthesis
T14982 6266-6273 Positive_regulation denotes promote
T14981 5989-5993 Negative_regulation denotes zVAD
T14980 5930-5944 Phosphorylation denotes phosphorylated
T14979 5681-5696 Phosphorylation denotes phosphorylation
T14978 5533-5548 Phosphorylation denotes phosphorylation
T14977 5511-5520 Positive_regulation denotes promoting
T14976 5260-5274 Phosphorylation denotes phosphorylated
T14975 5187-5193 Gene_expression denotes active
T14974 5057-5071 Phosphorylation denotes phosphorylated
T14973 4538-4547 Negative_regulation denotes reduction
T14972 3959-3968 Gene_expression denotes expressed
T14971 3920-3930 Gene_expression denotes production
T14970 3763-3778 Phosphorylation denotes phosphorylation
T14969 3637-3652 Phosphorylation denotes phosphorylation
T14968 3689-3698 Positive_regulation denotes increased
T14967 3570-3584 Phosphorylation denotes phosphorylated
T14966 3466-3475 Positive_regulation denotes increased
T14965 3248-3257 Positive_regulation denotes increased
T14964 3267-3277 Gene_expression denotes expression
T14961 3117-3126 Positive_regulation denotes increased
T14960 1328-1340 Positive_regulation denotes upregulation
T14959 1298-1313 Phosphorylation denotes phosphorylation
T14958 678-688 Gene_expression denotes expressing
T14957 115-125 Gene_expression denotes expressing
T14956 6274-6278 Protein denotes TNFα
T14955 6028-6034 Protein denotes p70S6K
T14954 6018-6022 Protein denotes MDM2
T14953 6011-6016 Protein denotes Foxo4
T14952 6004-6009 Protein denotes FoxO1
T14951 5952-5959 Protein denotes Myr-Akt
T14950 5845-5850 Protein denotes T308D
T14949 5601-5606 Protein denotes T308D
T14948 5571-5575 Protein denotes TNFα
T14947 5560-5565 Protein denotes c-Jun
T14946 5395-5399 Protein denotes PDK1
T14945 5225-5230 Protein denotes S473A
T14944 5158-5163 Protein denotes S473A
T14943 5033-5045 Protein denotes S473D mutant
T14942 4577-4580 Protein denotes Akt
T14941 3969-3976 Protein denotes Myr-Akt
T14940 3915-3919 Protein denotes TNFα
T14939 3782-3789 Protein denotes Myr-Akt
T14938 3666-3670 Protein denotes MDM2
T14937 3656-3661 Protein denotes FoxO1
T14936 3552-3557 Protein denotes FoxO4
T14935 3538-3540 Protein denotes S6
T14934 3530-3536 Protein denotes p70S6K
T14933 3494-3501 Protein denotes Myr-Akt
T14932 3302-3307 Protein denotes K179M
T14931 3281-3288 Protein denotes Myr-Akt
T14930 3127-3134 Protein denotes Myr-Akt
T14929 3090-3097 Protein denotes Myr-Akt
T14927 1755-1759 Protein denotes RIP1
T14926 1646-1650 Protein denotes RIP1
T14925 1344-1348 Protein denotes TNFα
T14924 1292-1297 Protein denotes c-Jun
T14923 1088-1095 Protein denotes Myr-Akt
T14922 996-1001 Protein denotes K179M
T14921 975-982 Protein denotes Myr-Akt
T14920 689-696 Protein denotes Myr-Akt
T14919 364-371 Protein denotes Myr-Akt
T14918 358-362 Protein denotes Akt1
T14917 286-290 Protein denotes RIP1
T14916 210-215 Protein denotes K179M
T14915 164-171 Protein denotes Myr-Akt
T14914 158-162 Protein denotes Akt1
R9911 T14914 T14957 themeOf Akt1,expressing
R9912 T14915 T14957 themeOf Myr-Akt,expressing
R9913 T14916 T14957 themeOf K179M,expressing
R9914 T14920 T14958 themeOf Myr-Akt,expressing
R9915 T14924 T14959 themeOf c-Jun,phosphorylation
R9916 T14925 T14960 themeOf TNFα,upregulation
R9919 T14930 T14961 themeOf Myr-Akt,increased
R9920 T14931 T14964 themeOf Myr-Akt,expression
R9921 T14932 T14964 themeOf K179M,expression
R9922 T14933 T14966 themeOf Myr-Akt,increased
R9923 T14934 T14967 themeOf p70S6K,phosphorylated
R9924 T14935 T14967 themeOf S6,phosphorylated
R9925 T14936 T14967 themeOf FoxO4,phosphorylated
R9926 T14937 T14969 themeOf FoxO1,phosphorylation
R9927 T14938 T14969 themeOf MDM2,phosphorylation
R9928 T14939 T14970 themeOf Myr-Akt,phosphorylation
R9929 T14940 T14971 themeOf TNFα,production
R9930 T14941 T14972 themeOf Myr-Akt,expressed
R9931 T14942 T14973 themeOf Akt,reduction
R9932 T14943 T14974 themeOf S473D mutant,phosphorylated
R9933 T14944 T14975 themeOf S473A,active
R9934 T14945 T14976 themeOf S473A,phosphorylated
R9935 T14947 T14978 themeOf c-Jun,phosphorylation
R9936 T14948 T14977 themeOf TNFα,promoting
R9937 T14949 T14979 themeOf T308D,phosphorylation
R9938 T14953 T14980 themeOf Foxo4,phosphorylated
R9939 T14953 T14981 themeOf Foxo4,zVAD
R9940 T14956 T14983 themeOf TNFα,synthesis
R9943 T14964 T14965 themeOf expression,increased
R9944 T14964 T14965 themeOf expression,increased
R9945 T14969 T14968 themeOf phosphorylation,increased
R9946 T14969 T14968 themeOf phosphorylation,increased
R9947 T14978 T14977 themeOf phosphorylation,promoting
R9948 T14983 T14982 themeOf synthesis,promote
R21761 T31430 T31433 themeOf TNFα,levels

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T31704 2961-2965 Protein denotes TNFα
T31703 2730-2733 Protein denotes 18S
T31702 2659-2663 Protein denotes TNFα
T15293 6279-6288 Gene_expression denotes synthesis
T15292 6266-6273 Positive_regulation denotes promote
T15291 5681-5696 Phosphorylation denotes phosphorylation
T15290 5511-5520 Positive_regulation denotes promoting
T15289 5533-5548 Phosphorylation denotes phosphorylation
T15288 5260-5274 Phosphorylation denotes phosphorylated
T15287 5057-5071 Phosphorylation denotes phosphorylated
T15286 4538-4547 Negative_regulation denotes reduction
T15285 3959-3968 Gene_expression denotes expressed
T15284 3920-3930 Gene_expression denotes production
T15283 3689-3698 Positive_regulation denotes increased
T15282 3637-3652 Phosphorylation denotes phosphorylation
T15281 3763-3778 Phosphorylation denotes phosphorylation
T15280 3570-3584 Phosphorylation denotes phosphorylated
T15279 3267-3277 Gene_expression denotes expression
T15278 3248-3257 Positive_regulation denotes increased
T15276 3117-3126 Positive_regulation denotes increased
T15274 1328-1340 Positive_regulation denotes upregulation
T15273 1298-1313 Phosphorylation denotes phosphorylation
T15272 678-688 Gene_expression denotes expressing
T15246 3302-3307 Protein denotes K179M
T15245 3281-3288 Protein denotes Myr-Akt
T15244 3127-3134 Protein denotes Myr-Akt
T15243 3090-3097 Protein denotes Myr-Akt
T15241 1755-1759 Protein denotes RIP1
T15240 1646-1650 Protein denotes RIP1
T15239 1344-1348 Protein denotes TNFα
T15238 1292-1297 Protein denotes c-Jun
T15237 1088-1095 Protein denotes Myr-Akt
T15236 996-1001 Protein denotes K179M
T15235 975-982 Protein denotes Myr-Akt
T15234 689-696 Protein denotes Myr-Akt
T15233 364-371 Protein denotes Myr-Akt
T15232 358-362 Protein denotes Akt1
T15231 286-290 Protein denotes RIP1
T15230 210-215 Protein denotes K179M
T15229 164-171 Protein denotes Myr-Akt
T15228 158-162 Protein denotes Akt1
T15259 5225-5230 Protein denotes S473A
T15258 5158-5163 Protein denotes S473A
T15257 5033-5045 Protein denotes S473D mutant
T15256 4577-4580 Protein denotes Akt
T15255 3969-3976 Protein denotes Myr-Akt
T15254 3915-3919 Protein denotes TNFα
T15253 3782-3789 Protein denotes Myr-Akt
T15252 3666-3670 Protein denotes MDM2
T15251 3656-3661 Protein denotes FoxO1
T15250 3552-3557 Protein denotes FoxO4
T15249 3538-3540 Protein denotes S6
T15248 3530-3536 Protein denotes p70S6K
T15247 3494-3501 Protein denotes Myr-Akt
T15271 115-125 Gene_expression denotes expressing
T15270 6274-6278 Protein denotes TNFα
T15269 6028-6034 Protein denotes p70S6K
T15268 6018-6022 Protein denotes MDM2
T15267 6011-6016 Protein denotes Foxo4
T15266 6004-6009 Protein denotes FoxO1
T15265 5952-5959 Protein denotes Myr-Akt
T15264 5845-5850 Protein denotes T308D
T15263 5601-5606 Protein denotes T308D
T15262 5571-5575 Protein denotes TNFα
T15261 5560-5565 Protein denotes c-Jun
T15260 5395-5399 Protein denotes PDK1
R10009 T15228 T15271 themeOf Akt1,expressing
R10010 T15229 T15271 themeOf Myr-Akt,expressing
R10011 T15230 T15271 themeOf K179M,expressing
R10012 T15234 T15272 themeOf Myr-Akt,expressing
R10013 T15238 T15273 themeOf c-Jun,phosphorylation
R10014 T15239 T15274 themeOf TNFα,upregulation
R10017 T15245 T15279 themeOf Myr-Akt,expression
R10018 T15248 T15280 themeOf p70S6K,phosphorylated
R10019 T15249 T15280 themeOf S6,phosphorylated
R10020 T15250 T15280 themeOf FoxO4,phosphorylated
R10021 T15251 T15282 themeOf FoxO1,phosphorylation
R10022 T15252 T15282 themeOf MDM2,phosphorylation
R10023 T15253 T15281 themeOf Myr-Akt,phosphorylation
R10024 T15254 T15284 themeOf TNFα,production
R10025 T15255 T15285 themeOf Myr-Akt,expressed
R10026 T15256 T15286 themeOf Akt,reduction
R10027 T15257 T15287 themeOf S473D mutant,phosphorylated
R10028 T15259 T15288 themeOf S473A,phosphorylated
R10029 T15261 T15290 themeOf c-Jun,promoting
R10030 T15261 T15289 themeOf c-Jun,phosphorylation
R10031 T15263 T15291 themeOf T308D,phosphorylation
R10032 T15270 T15293 themeOf TNFα,synthesis
R10037 T15279 T15278 themeOf expression,increased
R10038 T15282 T15283 themeOf phosphorylation,increased
R10039 T15282 T15283 themeOf phosphorylation,increased
R10040 T15289 T15290 themeOf phosphorylation,promoting
R10041 T15293 T15292 themeOf synthesis,promote

DLUT931

Id Subject Object Predicate Lexical cue
T15160 4538-4547 Negative_regulation denotes reduction
T15159 3959-3968 Gene_expression denotes expressed
T15158 3920-3930 Gene_expression denotes production
T15157 3763-3778 Phosphorylation denotes phosphorylation
T15156 3689-3698 Positive_regulation denotes increased
T15155 3637-3652 Phosphorylation denotes phosphorylation
T15154 3570-3584 Phosphorylation denotes phosphorylated
T15153 3466-3475 Positive_regulation denotes increased
T15152 3248-3257 Positive_regulation denotes increased
T15151 3267-3277 Gene_expression denotes expression
T15148 1270-1280 Positive_regulation denotes activation
T15147 1328-1340 Positive_regulation denotes upregulation
T15146 1298-1313 Phosphorylation denotes phosphorylation
T15145 678-688 Gene_expression denotes expressing
T15144 115-125 Gene_expression denotes expressing
T15143 6274-6278 Protein denotes TNFα
T15142 6028-6034 Protein denotes p70S6K
T15141 6018-6022 Protein denotes MDM2
T15140 6011-6016 Protein denotes Foxo4
T15139 6004-6009 Protein denotes FoxO1
T15138 5952-5959 Protein denotes Myr-Akt
T15137 5845-5850 Protein denotes T308D
T15136 5601-5606 Protein denotes T308D
T15135 5571-5575 Protein denotes TNFα
T15134 5560-5565 Protein denotes c-Jun
T15133 5395-5399 Protein denotes PDK1
T15132 5225-5230 Protein denotes S473A
T15131 5158-5163 Protein denotes S473A
T15130 5033-5045 Protein denotes S473D mutant
T15129 4577-4580 Protein denotes Akt
T15128 3969-3976 Protein denotes Myr-Akt
T15127 3915-3919 Protein denotes TNFα
T15126 3782-3789 Protein denotes Myr-Akt
T15125 3666-3670 Protein denotes MDM2
T15124 3656-3661 Protein denotes FoxO1
T15123 3552-3557 Protein denotes FoxO4
T15122 3538-3540 Protein denotes S6
T15121 3530-3536 Protein denotes p70S6K
T15120 3494-3501 Protein denotes Myr-Akt
T15119 3302-3307 Protein denotes K179M
T15118 3281-3288 Protein denotes Myr-Akt
T15117 3127-3134 Protein denotes Myr-Akt
T15116 3090-3097 Protein denotes Myr-Akt
T15114 1755-1759 Protein denotes RIP1
T15113 1646-1650 Protein denotes RIP1
T15112 1344-1348 Protein denotes TNFα
T15111 1292-1297 Protein denotes c-Jun
T15110 1088-1095 Protein denotes Myr-Akt
T15109 996-1001 Protein denotes K179M
T15108 975-982 Protein denotes Myr-Akt
T15107 689-696 Protein denotes Myr-Akt
T15106 364-371 Protein denotes Myr-Akt
T15105 358-362 Protein denotes Akt1
T15104 286-290 Protein denotes RIP1
T15103 210-215 Protein denotes K179M
T15102 164-171 Protein denotes Myr-Akt
T15101 158-162 Protein denotes Akt1
T15167 5882-5897 Phosphorylation denotes phosphorylation
T15166 5681-5696 Phosphorylation denotes phosphorylation
T15165 5533-5548 Phosphorylation denotes phosphorylation
T15164 5511-5520 Positive_regulation denotes promoting
T15163 5403-5416 Phosphorylation denotes phosphorylate
T15162 5260-5274 Phosphorylation denotes phosphorylated
T15161 5057-5071 Phosphorylation denotes phosphorylated
T15168 5930-5944 Phosphorylation denotes phosphorylated
T31470 2971-2977 Transcription denotes levels
T31469 2669-2675 Transcription denotes levels
T31468 2961-2965 Protein denotes TNFα
T31467 2730-2733 Protein denotes 18S
T31466 2659-2663 Protein denotes TNFα
R9949 T15101 T15144 themeOf Akt1,expressing
R9950 T15102 T15144 themeOf Myr-Akt,expressing
R9951 T15103 T15144 themeOf K179M,expressing
R9952 T15107 T15145 themeOf Myr-Akt,expressing
R9953 T15111 T15146 themeOf c-Jun,phosphorylation
R9954 T15112 T15147 themeOf TNFα,upregulation
R9957 T15118 T15151 themeOf Myr-Akt,expression
R9958 T15119 T15151 themeOf K179M,expression
R9959 T15120 T15153 themeOf Myr-Akt,increased
R9960 T15121 T15154 themeOf p70S6K,phosphorylated
R9961 T15122 T15154 themeOf S6,phosphorylated
R9962 T15123 T15154 themeOf FoxO4,phosphorylated
R9963 T15124 T15155 themeOf FoxO1,phosphorylation
R9964 T15125 T15155 themeOf MDM2,phosphorylation
R9965 T15126 T15157 themeOf Myr-Akt,phosphorylation
R9966 T15127 T15158 themeOf TNFα,production
R9967 T15128 T15159 themeOf Myr-Akt,expressed
R9968 T15129 T15160 themeOf Akt,reduction
R9969 T15130 T15161 themeOf S473D mutant,phosphorylated
R9970 T15132 T15162 themeOf S473A,phosphorylated
R9971 T15133 T15163 themeOf PDK1,phosphorylate
R9972 T15134 T15165 themeOf c-Jun,phosphorylation
R9973 T15135 T15164 themeOf TNFα,promoting
R9974 T15136 T15166 themeOf T308D,phosphorylation
R9975 T15137 T15167 themeOf T308D,phosphorylation
R9976 T15138 T15168 themeOf Myr-Akt,phosphorylated
R9977 T15139 T15168 themeOf FoxO1,phosphorylated
R9978 T15140 T15168 themeOf Foxo4,phosphorylated
R9979 T15141 T15168 themeOf MDM2,phosphorylated
R9980 T15142 T15168 themeOf p70S6K,phosphorylated
R9981 T15146 T15148 themeOf phosphorylation,activation
R9982 T15146 T15147 themeOf phosphorylation,upregulation
R9983 T15147 T15148 themeOf upregulation,activation
R9984 T15147 T15148 themeOf upregulation,activation
R9987 T15151 T15152 themeOf expression,increased
R9988 T15151 T15152 themeOf expression,increased
R9989 T15155 T15156 themeOf phosphorylation,increased
R9990 T15155 T15156 themeOf phosphorylation,increased
R9991 T15165 T15164 themeOf phosphorylation,promoting
R21762 T31466 T31469 themeOf TNFα,levels
R21763 T31468 T31470 themeOf TNFα,levels

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T31780 2575-2590 Entity denotes Myr-Akt K179KM,
T31779 2958-2988 Protein denotes of TNFα mRNA levels by qRT-PCR
T31778 2303-2310 Entity denotes Myr-Akt
T31777 2961-2965 Protein denotes TNFα
T31776 2315-2334 Entity denotes Myr-Akt K179M cells
T31775 2724-2737 Protein denotes mouse 18S RNA
T31774 2315-2334 Protein denotes Myr-Akt K179M cells
T31773 2730-2733 Protein denotes 18S
T31772 2767-2774 Entity denotes Myr-Akt
T31771 2992-3001 Protein denotes 9 hrs (G)
T31770 2659-2663 Protein denotes TNFα
T31769 2470-2488 Protein denotes Endogenous Akt (∼)
T31768 2940-2941 Entity denotes F
T31767 2315-2334 Entity denotes Myr-Akt K179M cells
T31766 2813-2819 Entity denotes Ser473
T31765 2369-2411 Protein denotes Nec-1 under serum free conditions for 9 hr
T31764 2096-2118 Protein denotes inactive Myr-Akt K179M
T31763 2160-2171 Entity denotes of zVAD.fmk
T31762 2745-2749 Entity denotes L929
T31761 2563-2570 Protein denotes Myr-Akt
T31760 2493-2500 Protein denotes Myr-Akt
T31759 2575-2590 Entity denotes Myr-Akt K179KM,
T31758 2659-2675 Protein denotes TNFα mRNA levels
T31757 2740-2743 Entity denotes E-G
T31756 2745-2819 Entity denotes L929 cells expressing Myr-Akt and Ala and Asp mutants of Thr308 and Ser473
T31755 2353-2361 Entity denotes zVAD.fmk
T31754 2096-2118 Entity denotes inactive Myr-Akt K179M
T31753 2802-2808 Entity denotes Thr308
T31752 2838-2846 Entity denotes zVAD.fmk
T31751 2458-2468 Entity denotes antibodies
T31750 2575-2590 Protein denotes Myr-Akt K179KM,
T31749 2067-2074 Entity denotes Myr-Akt
T31748 2493-2500 Entity denotes Myr-Akt
T31747 2067-2074 Protein denotes Myr-Akt
T31746 2563-2570 Entity denotes Myr-Akt
T31745 2787-2790 Protein denotes Asp
T31744 2981-2988 Protein denotes qRT-PCR
T31743 2243-2252 Protein denotes Nec-1 (B)
T31742 2767-2774 Protein denotes Myr-Akt
T31741 2612-2629 Entity denotes zVAD.fmk for 9 hr
T31740 2779-2782 Entity denotes Ala
T31739 2303-2310 Protein denotes Myr-Akt
T15771 3744-3789 Phosphorylation denotes necroptotic Thr308 phosphorylation of Myr-Akt
T15770 6290-6304 Positive_regulation denotes JNK activation
T15769 5533-5565 Phosphorylation denotes phosphorylation of JNK and c-Jun
T15768 5533-5565 Phosphorylation denotes phosphorylation of JNK and c-Jun
T15767 419-451 Positive_regulation denotes the addition of a myristoylation
T15766 1328-1353 Positive_regulation denotes upregulation of TNFα mRNA
T15765 1582-1596 Positive_regulation denotes Akt activation
T15764 3263-3315 Gene_expression denotes the expression of Myr-Akt, but not the K179M mutant,
T15762 4973-5000 Positive_regulation denotes promote necroptotic changes
T15761 3462-3501 Positive_regulation denotes the increased basal activity of Myr-Akt
T15760 3899-3913 Positive_regulation denotes JNK activation
T15759 668-696 Gene_expression denotes the cells expressing Myr-Akt
T15758 1685-1699 Positive_regulation denotes Akt activation
T15757 301-315 Positive_regulation denotes Akt activation
T15755 3637-3727 Positive_regulation denotes phosphorylation of FoxO1 and MDM2 was significantly increased in the presence of zVAD.fmk,
T15754 3637-3727 Positive_regulation denotes phosphorylation of FoxO1 and MDM2 was significantly increased in the presence of zVAD.fmk,
T15752 1163-1192 Phosphorylation denotes in Akt Thr308 phosphorylation
T15751 3637-3670 Phosphorylation denotes phosphorylation of FoxO1 and MDM2
T15750 3637-3670 Phosphorylation denotes phosphorylation of FoxO1 and MDM2
T15749 1621-1644 Positive_regulation denotes growth factor signaling
T15748 336-386 Gene_expression denotes Constitutively active Akt1 (Myr-Akt) was generated
T15747 3887-3930 Gene_expression denotes cell death, JNK activation, TNFα production
T15746 1673-1718 Regulation denotes to regulate Akt activation during necroptosis
T15745 1227-1297 Positive_regulation denotes other zVAD.fmk-dependent events, including activation of JNK and c-Jun
T15744 1227-1297 Positive_regulation denotes other zVAD.fmk-dependent events, including activation of JNK and c-Jun
T15743 503-522 Entity denotes the plasma membrane
T15742 5571-5580 Protein denotes TNFα mRNA
T15741 3538-3540 Protein denotes S6
T15740 1206-1213 Protein denotes Myr-Akt
T15739 5636-5639 Protein denotes Akt
T15738 5821-5830 Entity denotes the cells
T15737 5804-5817 Entity denotes of substrates
T15736 5664-5696 Entity denotes perfect mimic of phosphorylation
T15735 1533-1551 Entity denotes membrane localized
T15734 4658-4683 Protein denotes Asp mutants at both sites
T15733 5075-5081 Entity denotes Thr308
T15732 6214-6217 Protein denotes Akt
T15702 301-304 Protein denotes Akt
T15701 4026-4029 Protein denotes Akt
T15700 5470-5476 Entity denotes Thr308
T15699 1233-1251 Entity denotes zVAD.fmk-dependent
T15698 3552-3557 Protein denotes FoxO4
T15697 1341-1353 Protein denotes of TNFα mRNA
T15696 4794-4805 Entity denotes Ala mutants
T15695 4910-4916 Entity denotes Ser473
T15694 1621-1634 Protein denotes growth factor
T15693 530-568 Protein denotes the deletion of the auto-inhibitory PH
T15692 4099-4105 Protein denotes of Akt
T15691 4582-4599 Protein denotes while Asp mutants
T15690 1646-1650 Protein denotes RIP1
T15689 5552-5555 Protein denotes JNK
T15688 4131-4134 Protein denotes Akt
T15687 5560-5565 Protein denotes c-Jun
T15686 4119-4123 Protein denotes Full
T15685 3170-3173 Protein denotes Akt
T15684 3229-3243 Entity denotes Akt substrates
T15683 1344-1348 Protein denotes TNFα
T15682 1088-1105 Protein denotes Myr-Akt dependent
T15681 141-172 Protein denotes active wild type Akt1 (Myr-Akt)
T15680 5318-5325 Entity denotes the Ala
T15679 6018-6022 Protein denotes MDM2
T15678 5376-5390 Entity denotes a docking site
T15677 3229-3232 Protein denotes Akt
T15676 4495-4498 Entity denotes Ala
T15675 3503-3558 Entity denotes Some substrates, including p70S6K, S6, GSK-3 and FoxO4,
T15673 4523-4529 Entity denotes Ser473
T15672 689-696 Protein denotes Myr-Akt
T15671 4160-4173 Entity denotes the PH domain
T15669 4391-4397 Entity denotes Thr308
T15668 1292-1297 Protein denotes c-Jun
T15667 975-1009 Entity denotes Myr-Akt, but not the K179M mutant,
T15666 3605-3616 Entity denotes of zVAD.fmk
T15665 5601-5650 Protein denotes T308D, in spite of being an active Akt construct,
T15664 5447-5450 Entity denotes Ala
T15663 3542-3547 Protein denotes GSK-3
T15662 4072-4108 Entity denotes that membrane localization of Akt is
T15661 6290-6293 Protein denotes JNK
T15660 1284-1287 Protein denotes JNK
T15659 750-780 Entity denotes the empty vector control cells
T15658 6036-6039 Protein denotes Fig
T15657 1025-1041 Entity denotes zVAD.fmk-induced
T15656 3656-3661 Protein denotes FoxO1
T15655 1442-1475 Entity denotes the apex of necroptotic signaling
T15654 4650-4653 Entity denotes Ala
T15653 194-215 Protein denotes inactive mutant K179M
T15652 4512-4518 Entity denotes Thr308
T15651 1315-1318 Protein denotes Fig
T15650 6193-6203 Protein denotes Akt kinase
T15649 1811-1814 Protein denotes Akt
T15648 3969-3976 Protein denotes Myr-Akt
T15646 5952-5959 Protein denotes Myr-Akt
T15645 6011-6016 Protein denotes Foxo4
T15644 3298-3314 Protein denotes the K179M mutant
T15643 1166-1169 Protein denotes Akt
T15642 4248-4254 Entity denotes Thr308
T15641 1646-1657 Protein denotes RIP1 kinase
T15640 1166-1176 Entity denotes Akt Thr308
T15639 5152-5163 Protein denotes while S473A
T15638 3715-3726 Entity denotes of zVAD.fmk
T15637 286-297 Protein denotes RIP1 kinase
T15636 5571-5575 Protein denotes TNFα
T15635 6111-6117 Entity denotes Thr308
T15634 351-372 Protein denotes active Akt1 (Myr-Akt)
T15633 164-171 Protein denotes Myr-Akt
T15632 3332-3347 Entity denotes these molecules
T15631 3779-3789 Protein denotes of Myr-Akt
T15630 3352-3366 Entity denotes Akt substrates
T15629 5417-5428 Entity denotes Thr308 [39]
T15628 4281-4289 Entity denotes zVAD.fmk
T15627 1194-1197 Protein denotes Fig
T15626 5395-5399 Protein denotes PDK1
T15625 4461-4467 Protein denotes of Akt
T15624 286-290 Protein denotes RIP1
T15623 5334-5342 Entity denotes 473 site
T15622 5845-5850 Protein denotes T308D
T15621 4899-4905 Entity denotes Thr308
T15620 3899-3902 Protein denotes JNK
T15619 1435-1438 Protein denotes Akt
T15618 3887-3919 Protein denotes cell death, JNK activation, TNFα
T15617 5225-5230 Protein denotes S473A
T15616 364-371 Protein denotes Myr-Akt
T15615 6235-6245 Entity denotes substrates
T15614 3491-3501 Protein denotes of Myr-Akt
T15613 602-637 Protein denotes Akt that is active under serum free
T15612 3127-3134 Protein denotes Myr-Akt
T15611 6004-6009 Protein denotes FoxO1
T15610 3278-3288 Protein denotes of Myr-Akt
T15609 3352-3355 Protein denotes Akt
T15608 4574-4580 Protein denotes of Akt
T15607 5901-6034 Entity denotes several substrates that were phosphorylated by the Myr-Akt construct in the presence of zVAD including FoxO1, Foxo4, MDM2, and p70S6K
T15606 1685-1688 Protein denotes Akt
T15731 6193-6196 Protein denotes Akt
T15730 668-696 Entity denotes the cells expressing Myr-Akt
T15729 873-888 Protein denotes that active Akt
T15728 5455-5476 Protein denotes Asp mutants of Thr308
T15727 5278-5284 Entity denotes Thr308
T15726 6274-6288 Protein denotes TNFα synthesis
T15725 1582-1585 Protein denotes Akt
T15724 1355-1358 Protein denotes Fig
T15723 5718-5731 Protein denotes of the kinase
T15722 569-585 Entity denotes domain (Fig. 7A)
T15721 1755-1766 Protein denotes RIP1 kinase
T15720 4182-4185 Entity denotes Myr
T15719 4164-4166 Protein denotes PH
T15718 3666-3670 Protein denotes MDM2
T15717 979-982 Protein denotes Akt
T15716 5029-5046 Protein denotes the S473D mutant,
T15715 975-1009 Entity denotes Myr-Akt, but not the K179M mutant,
T15714 3530-3536 Protein denotes p70S6K
T15713 4328-4331 Protein denotes Fig
T15712 1519-1555 Protein denotes of active and membrane localized Akt
T15711 4765-4782 Protein denotes to wild type Akt,
T15710 1755-1759 Protein denotes RIP1
T15709 4718-4734 Protein denotes both Asp mutants
T15708 3087-3097 Protein denotes of Myr-Akt
T15707 3403-3414 Entity denotes of zVAD.fmk
T15706 3756-3762 Entity denotes Thr308
T15705 6028-6034 Protein denotes p70S6K
T15704 992-1008 Protein denotes the K179M mutant
T15703 3851-3867 Entity denotes zVAD.fmk-induced
R10210 T15606 T15758 themeOf Akt,Akt activation
R10211 T15610 T15764 themeOf of Myr-Akt,"the expression of Myr-Akt, but not the K179M mutant,"
R10213 T15614 T15761 themeOf of Myr-Akt,the increased basal activity of Myr-Akt
R10214 T15618 T15747 themeOf "cell death, JNK activation, TNFα","cell death, JNK activation, TNFα production"
R10215 T15620 T15760 themeOf JNK,JNK activation
R10217 T15634 T15748 themeOf active Akt1 (Myr-Akt),Constitutively active Akt1 (Myr-Akt) was generated
R10218 T15640 T15643 partOf Akt Thr308,Akt
R10219 T15640 T15752 siteOf Akt Thr308,in Akt Thr308 phosphorylation
R10220 T15643 T15752 themeOf Akt,in Akt Thr308 phosphorylation
R10223 T15656 T15751 themeOf FoxO1,phosphorylation of FoxO1 and MDM2
R10224 T15660 T15744 themeOf JNK,"other zVAD.fmk-dependent events, including activation of JNK and c-Jun"
R10226 T15668 T15745 themeOf c-Jun,"other zVAD.fmk-dependent events, including activation of JNK and c-Jun"
R10227 T15672 T15759 themeOf Myr-Akt,the cells expressing Myr-Akt
R10229 T15687 T15768 themeOf c-Jun,phosphorylation of JNK and c-Jun
R10231 T15694 T15749 causeOf growth factor,growth factor signaling
R10232 T15697 T15766 themeOf of TNFα mRNA,upregulation of TNFα mRNA
R10233 T15702 T15757 themeOf Akt,Akt activation
R10234 T15706 T15631 partOf Thr308,of Myr-Akt
R10237 T15718 T15750 themeOf MDM2,phosphorylation of FoxO1 and MDM2
R10238 T15725 T15765 themeOf Akt,Akt activation
R10239 T15750 T15754 themeOf phosphorylation of FoxO1 and MDM2,"phosphorylation of FoxO1 and MDM2 was significantly increased in the presence of zVAD.fmk,"
R10240 T15751 T15755 themeOf phosphorylation of FoxO1 and MDM2,"phosphorylation of FoxO1 and MDM2 was significantly increased in the presence of zVAD.fmk,"
R10243 T15758 T15746 themeOf Akt activation,to regulate Akt activation during necroptosis
R10225 T15661 T15770 themeOf JNK,JNK activation
R10230 T15689 T15769 themeOf JNK,phosphorylation of JNK and c-Jun
R10235 T15706 T15771 siteOf Thr308,necroptotic Thr308 phosphorylation of Myr-Akt
R10216 T15631 T15771 themeOf of Myr-Akt,necroptotic Thr308 phosphorylation of Myr-Akt

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T31698 3040-3041 . denotes .
T31697 3033-3040 VBN denotes plotted
T31696 3029-3032 VBD denotes was
T31695 3026-3028 NNP denotes SD
T31694 3025-3026 NN denotes ±
T31693 3018-3025 JJ denotes average
T31692 3016-3017 , denotes ,
T31691 3010-3016 NNS denotes graphs
T31690 3006-3009 DT denotes all
T31689 3003-3005 IN denotes In
T31688 3001-3002 . denotes .
T31687 3000-3001 -RRB- denotes )
T31686 2999-3000 NNP denotes G
T31685 2998-2999 -LRB- denotes (
T31684 2994-2997 NNS denotes hrs
T31683 2992-2993 CD denotes 9
T31682 2989-2991 IN denotes at
T31681 2981-2988 NNP denotes qRT-PCR
T31680 2978-2980 IN denotes by
T31679 2971-2977 NNS denotes levels
T31678 2966-2970 NNP denotes mRNA
T31677 2961-2965 NNP denotes TNFα
T31676 2958-2960 IN denotes of
T31675 2947-2957 NN denotes evaluation
T31674 2944-2946 CC denotes or
T31673 2942-2943 , denotes ,
T31672 2941-2942 -RRB- denotes )
T31671 2940-2941 NN denotes F
T31670 2939-2940 -LRB- denotes (
T31669 2936-2938 NN denotes hr
T31668 2934-2935 CD denotes 9
T31667 2931-2933 IN denotes at
T31666 2926-2930 NN denotes blot
T31628 2737-2738 . denotes .
T31587 2515-2524 VBN denotes indicated
T31586 2511-2514 VBP denotes are
T31585 2505-2510 NNS denotes bands
T31584 2503-2504 -RRB- denotes )
T31583 2502-2503 SYM denotes *
T31582 2501-2502 -LRB- denotes (
T31581 2493-2500 NNP denotes Myr-Akt
T31580 2489-2492 CC denotes and
T31579 2487-2488 -RRB- denotes )
T31578 2486-2487 VBN denotes ∼
T31535 2252-2253 . denotes .
T31534 2251-2252 -RRB- denotes )
T31533 2250-2251 NNP denotes B
T31532 2249-2250 -LRB- denotes (
T31531 2243-2248 NN denotes Nec-1
T31530 2238-2242 IN denotes with
T31529 2227-2237 NNS denotes conditions
T31528 2222-2226 JJ denotes free
T31527 2216-2221 NN denotes serum
T31526 2213-2215 CC denotes or
T31525 2207-2212 NN denotes serum
T31524 2204-2206 CC denotes or
T31523 2202-2203 -RRB- denotes )
T31522 2201-2202 NNP denotes A
T31521 2200-2201 -LRB- denotes (
T31520 2189-2199 NNS denotes conditions
T31519 2184-2188 JJ denotes free
T31518 2178-2183 NN denotes serum
T31517 2172-2177 IN denotes under
T31516 2163-2171 NNP denotes zVAD.fmk
T31515 2160-2162 IN denotes of
T31514 2151-2159 NN denotes addition
T31513 2147-2150 DT denotes the
T31512 2144-2146 IN denotes by
T31511 2136-2143 VBN denotes induced
T31510 2132-2135 VBD denotes was
T31509 2120-2131 NNP denotes Necroptosis
T31508 2118-2119 . denotes .
T31507 2113-2118 NNP denotes K179M
T31506 2105-2112 NNP denotes Myr-Akt
T31505 2096-2104 JJ denotes inactive
T31504 2082-2095 RB denotes catalytically
T31503 2078-2081 DT denotes the
T31502 2075-2077 CC denotes or
T31501 2067-2074 NNP denotes Myr-Akt
T31500 2058-2066 VBG denotes encoding
T31499 2050-2057 NNS denotes viruses
T31498 2047-2049 CC denotes or
T31497 2036-2046 NN denotes retrovirus
T31496 2031-2035 NNP denotes MSCV
T31495 2025-2030 JJ denotes empty
T31494 2020-2024 IN denotes with
T31493 2011-2019 VBN denotes infected
T31492 2004-2010 RB denotes stably
T31491 1999-2003 VBD denotes were
T31577 2485-2486 -LRB- denotes (
T31576 2481-2484 NNP denotes Akt
T31575 2470-2480 NNP denotes Endogenous
T31574 2468-2469 . denotes .
T31573 2458-2468 NNS denotes antibodies
T31572 2448-2457 VBN denotes indicated
T31571 2444-2447 DT denotes the
T31570 2438-2443 VBG denotes using
T31569 2433-2437 NN denotes blot
T31568 2425-2432 JJ denotes western
T31567 2422-2424 IN denotes by
T31566 2413-2421 VBN denotes followed
T31565 2411-2412 , denotes ,
T31564 2409-2411 NN denotes hr
T31563 2407-2408 CD denotes 9
T31562 2403-2406 IN denotes for
T31561 2392-2402 NNS denotes conditions
T31560 2387-2391 JJ denotes free
T31559 2381-2386 NN denotes serum
T31558 2375-2380 IN denotes under
T31557 2369-2374 NNP denotes Nec-1
T31556 2362-2368 CC denotes and/or
T31555 2353-2361 NNP denotes zVAD.fmk
T31554 2348-2352 IN denotes with
T31553 2340-2347 VBN denotes treated
T31552 2335-2339 VBD denotes were
T31551 2329-2334 NNS denotes cells
T31550 2323-2328 NNP denotes K179M
T31549 2315-2322 NNP denotes Myr-Akt
T31548 2311-2314 CC denotes and
T31547 2303-2310 NNP denotes Myr-Akt
T31546 2301-2302 -RRB- denotes )
T31545 2300-2301 NNP denotes C
T31544 2299-2300 -LRB- denotes (
T31543 2297-2298 . denotes .
T31542 2295-2297 NN denotes hr
T31541 2292-2294 CD denotes 24
T31540 2286-2291 IN denotes after
T31539 2276-2285 VBN denotes performed
T31538 2271-2275 VBD denotes were
T31537 2264-2270 NNS denotes assays
T31536 2254-2263 NN denotes Viability
T16656 6328-6329 . denotes .
T16655 6323-6328 NN denotes death
T16654 6318-6322 NN denotes cell
T16653 6309-6317 JJ denotes eventual
T16652 6305-6308 CC denotes and
T16651 6294-6304 NN denotes activation
T16650 6290-6293 NNP denotes JNK
T16649 6288-6289 , denotes ,
T16648 6279-6288 NN denotes synthesis
T16647 6274-6278 NNP denotes TNFα
T16646 6266-6273 VB denotes promote
T16645 6264-6265 , denotes ,
T16644 6253-6264 NN denotes necroptosis
T16643 6246-6252 IN denotes during
T16642 6235-6245 NNS denotes substrates
T16641 6221-6234 VB denotes phosphorylate
T16640 6218-6220 TO denotes to
T16639 6214-6217 NNP denotes Akt
T16583 5882-5897 NN denotes phosphorylation
T16582 5871-5881 JJ denotes downstream
T16581 5867-5870 DT denotes the
T16580 5859-5866 VB denotes support
T16579 5855-5858 RB denotes not
T16578 5851-5854 VBD denotes did
T16577 5845-5850 CD denotes T308D
T16576 5843-5844 , denotes ,
T16575 5837-5843 VBN denotes tested
T16574 5832-5836 WRB denotes When
T16573 5830-5831 . denotes .
T16572 5825-5830 NNS denotes cells
T16571 5821-5824 DT denotes the
T16570 5818-5820 IN denotes in
T16569 5807-5817 NNS denotes substrates
T16568 5804-5806 IN denotes of
T16567 5793-5803 NN denotes repertoire
T16566 5786-5792 JJ denotes entire
T16565 5782-5785 DT denotes the
T16564 5768-5781 VB denotes phosphorylate
T16563 5765-5767 TO denotes to
T16562 5756-5764 NN denotes activity
T16561 5745-5755 JJ denotes sufficient
T16560 5740-5744 VB denotes have
T16559 5736-5739 RB denotes not
T16558 5732-5735 MD denotes may
T16557 5725-5731 NN denotes kinase
T16556 5721-5724 DT denotes the
T16555 5718-5720 IN denotes of
T16554 5713-5717 NN denotes form
T16553 5706-5712 JJ denotes mutant
T16552 5701-5705 DT denotes this
T16551 5697-5700 CC denotes and
T16550 5681-5696 NN denotes phosphorylation
T16549 5678-5680 IN denotes of
T16548 5672-5677 VB denotes mimic
T16547 5664-5671 JJ denotes perfect
T16546 5662-5663 DT denotes a
T16545 5659-5661 VB denotes be
T16544 5655-5658 RB denotes not
T16543 5651-5654 MD denotes may
T16542 5649-5650 , denotes ,
T16541 5640-5649 VBP denotes construct
T16540 5636-5639 NNP denotes Akt
T16539 5629-5635 JJ denotes active
T16538 5626-5628 DT denotes an
T16537 5620-5625 VBG denotes being
T16536 5617-5619 IN denotes of
T16535 5611-5616 NN denotes spite
T16534 5608-5610 IN denotes in
T16533 5606-5607 , denotes ,
T16532 5601-5606 CD denotes T308D
T16531 5596-5600 IN denotes that
T16530 5587-5595 VBZ denotes suggests
T16529 5582-5586 DT denotes This
T16528 5580-5581 . denotes .
T16527 5576-5580 NNP denotes mRNA
T16526 5571-5575 NNP denotes TNFα
T16525 5567-5570 CC denotes and
T16524 5565-5566 , denotes ,
T16523 5560-5565 NNP denotes c-Jun
T16522 5556-5559 CC denotes and
T16521 5552-5555 NNP denotes JNK
T16520 5549-5551 IN denotes of
T16519 5533-5548 NN denotes phosphorylation
T16518 5531-5532 , denotes ,
T16517 5526-5531 NN denotes death
T16516 5521-5525 NN denotes cell
T16515 5511-5520 VBG denotes promoting
T16514 5508-5510 IN denotes in
T16513 5501-5507 JJ denotes active
T16512 5496-5500 RBR denotes less
T16511 5482-5495 RB denotes significantly
T16510 5477-5481 VBD denotes were
T16509 5470-5476 CD denotes Thr308
T16508 5467-5469 IN denotes of
T16507 5459-5466 NNS denotes mutants
T16506 5455-5458 NNP denotes Asp
T16505 5451-5454 CC denotes and
T16504 5447-5450 NNP denotes Ala
T16503 5442-5446 DT denotes both
T16502 5440-5441 , denotes ,
T16501 5430-5440 RB denotes Strikingly
T16500 5428-5429 . denotes .
T16499 5427-5428 NNP denotes ]
T16498 5425-5427 CD denotes 39
T16497 5424-5425 NNP denotes [
T16496 5417-5423 NNP denotes Thr308
T16495 5403-5416 VB denotes phosphorylate
T16494 5400-5402 TO denotes to
T16493 5395-5399 CD denotes PDK1
T16492 5391-5394 IN denotes for
T16491 5386-5390 NN denotes site
T16490 5378-5385 NN denotes docking
T16489 5376-5377 DT denotes a
T16488 5368-5375 VB denotes provide
T16487 5364-5367 CC denotes and
T16486 5349-5363 VBN denotes phosphorylated
T16485 5346-5348 VB denotes be
T16484 5343-5345 TO denotes to
T16483 5338-5342 NN denotes site
T16482 5334-5337 CD denotes 473
T16481 5326-5333 VBD denotes mutated
T16480 5322-5325 NNP denotes Ala
T16479 5318-5321 DT denotes the
T16478 5315-5317 IN denotes of
T16477 5305-5314 NN denotes inability
T16476 5301-5304 DT denotes the
T16475 5298-5300 TO denotes to
T16474 5294-5297 JJ denotes due
T16473 5285-5293 RB denotes possibly
T16472 5278-5284 CD denotes Thr308
T16471 5275-5277 IN denotes on
T16470 5260-5274 VBN denotes phosphorylated
T16469 5248-5259 RB denotes efficiently
T16468 5245-5247 VB denotes be
T16467 5242-5244 TO denotes to
T16466 5235-5241 JJ denotes unable
T16465 5231-5234 VBD denotes was
T16464 5225-5230 CD denotes S473A
T16463 5223-5224 . denotes .
T16462 5212-5223 NN denotes necroptosis
T16461 5209-5211 IN denotes of
T16460 5201-5208 NNS denotes aspects
T16459 5197-5200 DT denotes all
T16458 5194-5196 IN denotes in
T16457 5187-5193 JJ denotes active
T16456 5182-5186 RBR denotes less
T16455 5168-5181 RB denotes significantly
T16454 5164-5167 VBD denotes was
T16453 5158-5163 NNP denotes S473A
T16452 5152-5157 IN denotes while
T16451 5150-5151 , denotes ,
T16450 5142-5150 NN denotes activity
T16449 5134-5141 JJ denotes reduced
T16448 5125-5133 RB denotes slightly
T16447 5120-5124 RB denotes only
T16405 4899-4905 NNP denotes Thr308
T16404 4897-4898 , denotes ,
T16403 4887-4897 NNS denotes activities
T16402 4877-4886 JJ denotes catalytic
T16401 4869-4876 JJ denotes similar
T16400 4861-4868 IN denotes Despite
T16399 4859-4860 . denotes .
T16398 4858-4859 -RRB- denotes )
T16397 4855-4858 CD denotes S8C
T16396 4853-4854 . denotes .
T16395 4850-4853 NNP denotes Fig
T16394 4849-4850 -LRB- denotes (
T16393 4840-4848 NN denotes activity
T16392 4837-4839 IN denotes in
T16391 4827-4836 VBZ denotes decreases
T16390 4816-4826 JJ denotes comparable
T16389 4806-4815 VBD denotes displayed
T16388 4798-4805 NNS denotes mutants
T16387 4794-4797 NNP denotes Ala
T16386 4789-4793 DT denotes both
T16339 4548-4550 IN denotes in
T16338 4538-4547 NN denotes reduction
T16337 4536-4537 DT denotes a
T16336 4530-4535 NN denotes cause
T16335 4523-4529 CD denotes Ser473
T16334 4519-4522 CC denotes and
T16333 4512-4518 CD denotes Thr308
T16332 4509-4511 IN denotes at
T16331 4499-4508 NNS denotes mutations
T16330 4495-4498 NNP denotes Ala
T16329 4490-4494 IN denotes that
T16328 4481-4489 VBN denotes reported
T16327 4476-4480 VBN denotes been
T16326 4472-4475 VBZ denotes has
T16325 4469-4471 PRP denotes It
T16324 4467-4468 . denotes .
T16323 4464-4467 NNP denotes Akt
T16322 4461-4463 IN denotes of
T16321 4451-4460 NNS denotes functions
T16320 4439-4450 JJ denotes necroptotic
T16319 4435-4438 DT denotes the
T16318 4432-4434 IN denotes of
T16317 4421-4431 NN denotes regulation
T16316 4417-4420 DT denotes the
T16315 4414-4416 IN denotes in
T16314 4398-4413 NN denotes phosphorylation
T16313 4391-4397 NNP denotes Thr308
T16312 4387-4390 IN denotes for
T16311 4382-4386 NN denotes role
T16310 4373-4381 JJ denotes critical
T16309 4369-4372 CC denotes and
T16308 4360-4368 JJ denotes specific
T16307 4358-4359 DT denotes a
T16306 4352-4357 VBD denotes found
T16305 4349-4351 PRP denotes we
T16304 4347-4348 , denotes ,
T16303 4341-4347 NNP denotes Second
T16302 4339-4340 . denotes .
T16301 4338-4339 -RRB- denotes )
T16300 4337-4338 NNP denotes B
T16299 4336-4337 , denotes ,
T16298 4333-4336 CD denotes S8A
T16297 4331-4332 . denotes .
T16296 4328-4331 NNP denotes Fig
T16295 4327-4328 -LRB- denotes (
T16294 4316-4326 NNS denotes conditions
T16293 4311-4315 JJ denotes free
T16292 4305-4310 NN denotes serum
T16291 4299-4304 IN denotes under
T16290 4290-4298 NN denotes addition
T16289 4281-4289 NNP denotes zVAD.fmk
T16288 4271-4280 VBG denotes following
T16287 4255-4270 NN denotes phosphorylation
T16286 4248-4254 JJ denotes Thr308
T16285 4238-4247 VBN denotes increased
T16284 4235-4237 CC denotes or
T16283 4229-4234 NN denotes death
T16282 4224-4228 NN denotes cell
T16281 4221-4223 IN denotes of
T16280 4210-4220 NN denotes activation
T16279 4206-4209 DT denotes the
T16278 4198-4205 VB denotes support
T16277 4194-4197 RB denotes not
T16276 4190-4193 VBD denotes did
T16275 4186-4189 NN denotes tag
T16274 4182-4185 NNP denotes Myr
T16273 4178-4181 DT denotes the
T16272 4174-4177 CC denotes and
T16271 4167-4173 NN denotes domain
T16270 4164-4166 NNP denotes PH
T16269 4160-4163 DT denotes the
T16268 4155-4159 DT denotes both
T16267 4147-4154 VBG denotes lacking
T16266 4140-4146 JJ denotes mutant
T16265 4138-4139 DT denotes a
T16264 4135-4137 CC denotes or
T16263 4131-4134 NNP denotes Akt
T16262 4124-4130 NN denotes length
T16261 4119-4123 JJ denotes Full
T16260 4117-4118 . denotes .
T16259 4109-4117 VBN denotes required
T16258 4106-4108 VBZ denotes is
T16257 4102-4105 NNP denotes Akt
T16256 4099-4101 IN denotes of
T16255 4086-4098 NN denotes localization
T16254 4077-4085 NN denotes membrane
T16253 4072-4076 IN denotes that
T16252 4066-4071 VBD denotes found
T16251 4063-4065 PRP denotes we
T16250 4061-4062 , denotes ,
T16249 4056-4061 RB denotes First
T16248 4054-4055 . denotes .
T16247 4043-4054 NN denotes necroptosis
T16246 4040-4042 IN denotes on
T16245 4030-4039 NNS denotes mutations
T16244 4026-4029 NNP denotes Akt
T16243 4020-4025 JJ denotes other
T16242 4017-4019 IN denotes of
T16241 4009-4016 NNS denotes effects
T16240 4005-4008 DT denotes the
T16239 3997-4004 VB denotes examine
T16238 3994-3996 TO denotes to
T16237 3991-3993 PRP denotes us
T16236 3983-3990 VBD denotes allowed
T16235 3978-3982 DT denotes This
T16234 3976-3977 . denotes .
T16233 3969-3976 NNP denotes Myr-Akt
T16232 3959-3968 VBN denotes expressed
T16231 3954-3958 JJ denotes over
T16230 3950-3953 DT denotes the
T16229 3947-3949 IN denotes on
T16228 3937-3946 JJ denotes dependent
T16227 3932-3936 VBD denotes were
T16226 3930-3931 -RRB- denotes )
T16225 3920-3930 NN denotes production
T16224 3915-3919 JJ denotes TNFα
T16223 3913-3914 , denotes ,
T16222 3903-3913 NN denotes activation
T16221 3899-3902 NNP denotes JNK
T16220 3897-3898 , denotes ,
T16219 3892-3897 NN denotes death
T16218 3887-3891 NN denotes cell
T16217 3886-3887 -LRB- denotes (
T16216 3879-3885 NNS denotes events
T16215 3868-3878 JJ denotes downstream
T16214 3851-3867 JJ denotes zVAD.fmk-induced
T16213 3847-3850 DT denotes all
T16212 3836-3846 NNS denotes conditions
T16211 3831-3835 JJ denotes free
T16210 3825-3830 NN denotes serum
T16209 3819-3824 IN denotes Under
T16208 3817-3818 . denotes .
T16207 3809-3817 NN denotes activity
T16206 3805-3808 PRP$ denotes its
T16205 3796-3804 VBD denotes promoted
T16204 3790-3795 RB denotes still
T16203 3782-3789 NNP denotes Myr-Akt
T16202 3779-3781 IN denotes of
T16201 3763-3778 NN denotes phosphorylation
T16200 3756-3762 NNP denotes Thr308
T16199 3744-3755 JJ denotes necroptotic
T16198 3739-3743 IN denotes that
T16197 3728-3738 VBG denotes indicating
T16196 3726-3727 , denotes ,
T16195 3718-3726 NNP denotes zVAD.fmk
T16194 3715-3717 IN denotes of
T16193 3706-3714 NN denotes presence
T16192 3702-3705 DT denotes the
T16191 3699-3701 IN denotes in
T16190 3689-3698 VBN denotes increased
T16189 3675-3688 RB denotes significantly
T16188 3671-3674 VBD denotes was
T16187 3666-3670 NNP denotes MDM2
T16186 3662-3665 CC denotes and
T16185 3656-3661 NNP denotes FoxO1
T16184 3653-3655 IN denotes of
T16183 3637-3652 NN denotes phosphorylation
T16182 3635-3636 , denotes ,
T16181 3631-3635 NN denotes hand
T16180 3625-3630 JJ denotes other
T16179 3621-3624 DT denotes the
T16178 3618-3620 IN denotes On
T16177 3616-3617 . denotes .
T16176 3608-3616 NNP denotes zVAD.fmk
T16175 3605-3607 IN denotes of
T16174 3597-3604 NN denotes absence
T16173 3593-3596 DT denotes the
T16172 3590-3592 IN denotes in
T16171 3585-3589 RB denotes even
T16170 3570-3584 VBN denotes phosphorylated
T16169 3564-3569 RB denotes fully
T16168 3559-3563 VBD denotes were
T16167 3557-3558 , denotes ,
T16166 3552-3557 NNP denotes FoxO4
T16165 3548-3551 CC denotes and
T16164 3542-3547 NNP denotes GSK-3
T16163 3540-3541 , denotes ,
T16162 3538-3540 NNP denotes S6
T16161 3536-3537 , denotes ,
T16160 3530-3536 NNP denotes p70S6K
T16159 3520-3529 VBG denotes including
T16158 3518-3519 , denotes ,
T16157 3508-3518 NNS denotes substrates
T16156 3503-3507 DT denotes Some
T16155 3501-3502 . denotes .
T16154 3494-3501 NNP denotes Myr-Akt
T16153 3491-3493 IN denotes of
T16152 3482-3490 NN denotes activity
T16151 3476-3481 NN denotes basal
T16150 3466-3475 VBN denotes increased
T16638 6205-6213 VBG denotes allowing
T16637 6203-6204 , denotes ,
T16636 6197-6203 NN denotes kinase
T16635 6193-6196 NNP denotes Akt
T16634 6189-6192 CC denotes and
T16633 6179-6188 NN denotes machinery
T16632 6167-6178 JJ denotes necroptotic
T16631 6159-6166 IN denotes between
T16630 6154-6158 NN denotes link
T16629 6145-6153 JJ denotes critical
T16628 6143-6144 DT denotes a
T16627 6134-6142 VBZ denotes provides
T16626 6118-6133 NN denotes phosphorylation
T16625 6111-6117 NNP denotes Thr308
T16624 6090-6110 JJ denotes necroptosis-specific
T16623 6085-6089 IN denotes that
T16622 6082-6084 VBZ denotes is
T16621 6080-6081 , denotes ,
T16620 6073-6080 NNS denotes results
T16619 6067-6072 DT denotes these
T16618 6064-6066 IN denotes on
T16617 6058-6063 VBN denotes based
T16616 6056-6057 , denotes ,
T16615 6051-6056 NN denotes model
T16614 6047-6050 PRP$ denotes Our
T16613 6045-6046 . denotes .
T16612 6044-6045 -RRB- denotes )
T16611 6041-6044 CD denotes S8D
T16610 6039-6040 . denotes .
T16609 6036-6039 NNP denotes Fig
T16608 6035-6036 -LRB- denotes (
T16607 6028-6034 NNP denotes p70S6K
T16606 6024-6027 CC denotes and
T16605 6022-6023 , denotes ,
T16604 6018-6022 NNP denotes MDM2
T16603 6016-6017 , denotes ,
T16602 6011-6016 NNP denotes Foxo4
T16601 6009-6010 , denotes ,
T16600 6004-6009 NNP denotes FoxO1
T16599 5994-6003 VBG denotes including
T16598 5989-5993 NNP denotes zVAD
T16597 5986-5988 IN denotes of
T16596 5977-5985 NN denotes presence
T16595 5973-5976 DT denotes the
T16594 5970-5972 IN denotes in
T16593 5960-5969 VBP denotes construct
T16592 5952-5959 NNP denotes Myr-Akt
T16591 5948-5951 DT denotes the
T16590 5945-5947 IN denotes by
T16589 5930-5944 VBN denotes phosphorylated
T16588 5925-5929 VBD denotes were
T16587 5920-5924 WDT denotes that
T16586 5909-5919 NNS denotes substrates
T16585 5901-5908 JJ denotes several
T16584 5898-5900 IN denotes of
T16149 3462-3465 DT denotes the
T16148 3459-3461 TO denotes to
T16147 3455-3458 JJ denotes due
T16146 3448-3454 JJ denotes likely
T16145 3446-3447 , denotes ,
T16144 3440-3446 VBD denotes varied
T16143 3424-3439 NN denotes phosphorylation
T16142 3418-3423 PRP$ denotes their
T16141 3415-3417 IN denotes on
T16140 3406-3414 NNP denotes zVAD.fmk
T16139 3403-3405 IN denotes of
T16138 3396-3402 NN denotes effect
T16137 3392-3395 DT denotes The
T16136 3390-3391 . denotes .
T16135 3389-3390 -RRB- denotes )
T16134 3387-3389 NNP denotes 7C
T16133 3382-3386 NNP denotes Fig.
T16132 3381-3382 -LRB- denotes (
T16131 3375-3380 NNS denotes cells
T16130 3370-3374 CD denotes L929
T16129 3367-3369 IN denotes in
T16128 3356-3366 VBZ denotes substrates
T16127 3352-3355 NNP denotes Akt
T16126 3348-3351 VBP denotes are
T16125 3338-3347 NNS denotes molecules
T16124 3332-3337 DT denotes these
T16104 3208-3218 RB denotes previously
T16103 3203-3207 JJ denotes many
T16102 3200-3202 IN denotes of
T16101 3184-3199 NNP denotes Phosphorylation
T16100 3182-3183 . denotes .
T16099 3181-3182 -RRB- denotes )
T16098 3180-3181 CD denotes 5
T16097 3175-3179 NNP denotes Fig.
T16096 3174-3175 -LRB- denotes (
T16095 3170-3173 NNP denotes Akt
T16094 3159-3169 JJ denotes endogenous
T16093 3154-3158 IN denotes with
T16092 3150-3153 VBD denotes did
T16091 3147-3149 PRP denotes it
T16090 3144-3146 IN denotes as
T16089 3135-3143 NN denotes activity
T16088 3127-3134 NNP denotes Myr-Akt
T16087 3117-3126 VBD denotes increased
T16086 3105-3116 NN denotes necroptosis
T16085 3098-3104 IN denotes during
T16084 3090-3097 NNP denotes Myr-Akt
T16083 3087-3089 IN denotes of
T16078 1841-1842 . denotes .
T16077 1830-1841 NN denotes necroptosis
T16076 1823-1829 IN denotes during
T16075 1815-1822 NNS denotes changes
T16074 1811-1814 NNP denotes Akt
T16073 1807-1810 IN denotes for
T16072 1798-1806 VBN denotes required
T16071 1791-1797 NNS denotes inputs
T16070 1779-1790 JJ denotes independent
T16069 1775-1778 CD denotes two
T16068 1767-1774 VBP denotes provide
T16067 1760-1766 NN denotes kinase
T16066 1755-1759 CD denotes RIP1
T16065 1751-1754 CC denotes and
T16064 1743-1750 NNS denotes factors
T16063 1736-1742 NN denotes growth
T16062 1731-1735 IN denotes that
T16061 1720-1730 VBG denotes suggesting
T16060 1718-1719 , denotes ,
T16059 1707-1718 NN denotes necroptosis
T16058 1700-1706 IN denotes during
T16057 1689-1699 NN denotes activation
T16056 1685-1688 NNP denotes Akt
T16055 1676-1684 VB denotes regulate
T16054 1673-1675 TO denotes to
T16053 1668-1672 JJ denotes able
T16052 1662-1667 RB denotes still
T16051 1658-1661 VBD denotes was
T16050 1651-1657 NN denotes kinase
T16049 1646-1650 CD denotes RIP1
T16048 1644-1645 . denotes .
T16047 1635-1644 VBG denotes signaling
T16046 1628-1634 NN denotes factor
T16045 1621-1627 NN denotes growth
T16044 1616-1620 IN denotes from
T16043 1604-1615 NN denotes necroptosis
T16042 1597-1603 IN denotes during
T16041 1586-1596 NN denotes activation
T16040 1582-1585 NNP denotes Akt
T16039 1573-1581 VB denotes uncouple
T16038 1570-1572 TO denotes to
T16037 1559-1569 JJ denotes sufficient
T16036 1556-1558 VBZ denotes is
T16035 1552-1555 NNP denotes Akt
T16034 1542-1551 VBN denotes localized
T16033 1533-1541 JJ denotes membrane
T16032 1529-1532 CC denotes and
T16031 1522-1528 JJ denotes active
T16030 1519-1521 IN denotes of
T16029 1510-1518 NN denotes presence
T16028 1506-1509 DT denotes the
T16027 1501-1505 IN denotes that
T16026 1488-1500 VBD denotes demonstrated
T16025 1483-1487 NNS denotes data
T16024 1477-1482 DT denotes These
T16023 1475-1476 . denotes .
T16022 1466-1475 VBG denotes signaling
T16021 1454-1465 JJ denotes necroptotic
T16020 1451-1453 IN denotes of
T16019 1446-1450 NN denotes apex
T16018 1442-1445 DT denotes the
T16017 1439-1441 IN denotes at
T16016 1435-1438 NNP denotes Akt
T16015 1431-1434 IN denotes for
T16014 1426-1430 NN denotes role
T16013 1416-1425 JJ denotes important
T16012 1413-1415 DT denotes an
T16011 1402-1412 VBG denotes confirming
T16010 1400-1401 , denotes ,
T16009 1390-1400 NNS denotes conditions
T16008 1385-1389 JJ denotes free
T16007 1379-1384 NN denotes serum
T16006 1373-1378 IN denotes under
T16005 1367-1372 VB denotes occur
T16004 1364-1366 TO denotes to
T16003 1362-1363 -RRB- denotes )
T16002 1360-1362 NNP denotes 7D
T16001 1355-1359 NNP denotes Fig.
T16000 1354-1355 -LRB- denotes (
T15999 1349-1353 NNP denotes mRNA
T15998 1344-1348 NNP denotes TNFα
T15997 1341-1343 IN denotes of
T15996 1328-1340 NN denotes upregulation
T15995 1324-1327 CC denotes and
T15994 1322-1323 -RRB- denotes )
T15993 1320-1322 NNP denotes 7C
T15992 1315-1319 NNP denotes Fig.
T15991 1314-1315 -LRB- denotes (
T15990 1298-1313 NN denotes phosphorylation
T15989 1292-1297 JJ denotes c-Jun
T15988 1288-1291 CC denotes and
T15987 1284-1287 NNP denotes JNK
T15986 1281-1283 IN denotes of
T15985 1270-1280 NN denotes activation
T15984 1260-1269 VBG denotes including
T15983 1258-1259 , denotes ,
T15982 1252-1258 NNS denotes events
T15981 1233-1251 JJ denotes zVAD.fmk-dependent
T15980 1227-1232 JJ denotes other
T15979 1219-1226 VBD denotes allowed
T15978 1214-1218 RB denotes also
T15977 1206-1213 NNP denotes Myr-Akt
T15976 1204-1205 . denotes .
T15975 1203-1204 -RRB- denotes )
T15974 1202-1203 NNP denotes C
T15973 1201-1202 , denotes ,
T15972 1199-1201 NN denotes 7B
T15971 1194-1198 NNP denotes Fig.
T15970 1193-1194 -LRB- denotes (
T15969 1177-1192 NN denotes phosphorylation
T15968 1170-1176 NNP denotes Thr308
T15967 1166-1169 NNP denotes Akt
T15966 1163-1165 IN denotes in
T15965 1154-1162 NN denotes increase
T15964 1146-1153 JJ denotes delayed
T15963 1125-1145 JJ denotes necroptosis-specific
T15962 1121-1124 DT denotes the
T15961 1117-1120 CC denotes and
T15960 1111-1116 NN denotes death
T15959 1106-1110 NN denotes cell
T15958 1096-1105 JJ denotes dependent
T15957 1088-1095 NNP denotes Myr-Akt
T15956 1083-1087 DT denotes both
T15955 1073-1082 VBN denotes prevented
T15954 1067-1072 JJ denotes Nec-1
T15953 1065-1066 . denotes .
T15952 1064-1065 -RRB- denotes )
T15951 1063-1064 NNP denotes B
T15950 1062-1063 , denotes ,
T15949 1060-1062 NN denotes 7A
T15948 1055-1059 NNP denotes Fig.
T15947 1054-1055 -LRB- denotes (
T15946 1042-1053 NN denotes necroptosis
T15945 1025-1041 JJ denotes zVAD.fmk-induced
T15944 1016-1024 VBN denotes restored
T15943 1010-1015 RB denotes fully
T15942 1008-1009 , denotes ,
T15941 1002-1008 JJ denotes mutant
T15940 996-1001 NNP denotes K179M
T15939 992-995 DT denotes the
T15938 988-991 RB denotes not
T15937 984-987 CC denotes but
T15936 982-983 , denotes ,
T15935 975-982 NNP denotes Myr-Akt
T15934 964-974 NNS denotes conditions
T15933 959-963 JJ denotes free
T15932 953-958 NN denotes serum
T15931 947-952 IN denotes Under
T15930 945-946 . denotes .
T15929 940-945 NN denotes death
T15928 935-939 NN denotes cell
T15927 923-934 JJ denotes necroptotic
T15926 916-922 VB denotes induce
T15925 913-915 TO denotes to
T15924 902-912 JJ denotes sufficient
T15923 898-901 RB denotes not
T15922 895-897 VBZ denotes is
T15921 889-894 RB denotes alone
T15920 885-888 NNP denotes Akt
T15919 878-884 JJ denotes active
T15918 873-877 IN denotes that
T15917 863-872 VBZ denotes indicates
T15916 858-862 DT denotes This
T15915 856-857 . denotes .
T16349 4600-4608 NN denotes increase
T16348 4592-4599 NNS denotes mutants
T16347 4588-4591 NNP denotes Asp
T16346 4582-4587 IN denotes while
T16345 4580-4581 , denotes ,
T16344 4577-4580 NNP denotes Akt
T16343 4574-4576 IN denotes of
T16342 4565-4573 NN denotes activity
T16341 4555-4564 JJ denotes catalytic
T16340 4551-4554 DT denotes the
T15914 855-856 -RRB- denotes )
T15913 853-855 NN denotes 7B
T15912 848-852 NNP denotes Fig.
T15911 847-848 -LRB- denotes (
T15910 836-846 NN denotes starvation
T15909 830-835 NN denotes serum
T15908 827-829 IN denotes by
T15907 815-826 NN denotes necroptosis
T15906 808-814 VB denotes induce
T15905 805-807 TO denotes to
T15904 795-804 VBN denotes triggered
T15903 791-794 RB denotes not
T15902 786-790 VBD denotes were
T15901 782-785 CC denotes and
T15900 780-781 , denotes ,
T15899 775-780 NNS denotes cells
T15898 767-774 NN denotes control
T15897 760-766 NN denotes vector
T15896 754-759 JJ denotes empty
T15895 750-753 DT denotes the
T15894 745-749 IN denotes from
T15893 727-744 JJ denotes indistinguishable
T15892 720-726 NN denotes manner
T15891 718-719 DT denotes a
T15890 715-717 IN denotes in
T15889 710-714 VBD denotes grew
T15852 523-526 CC denotes and
T15851 514-522 NN denotes membrane
T15850 507-513 NN denotes plasma
T15849 503-506 DT denotes the
T15848 500-502 TO denotes to
T15847 487-499 NN denotes localization
T15846 474-486 JJ denotes constitutive
T15845 465-473 VBZ denotes provides
T15844 459-464 WDT denotes which
T15843 452-458 NN denotes signal
T15842 437-451 NN denotes myristoylation
T15841 435-436 DT denotes a
T15840 432-434 IN denotes of
T15839 423-431 NN denotes addition
T15838 419-422 DT denotes the
T15837 416-418 IN denotes by
T15836 414-415 NNP denotes ]
T15835 412-414 CD denotes 37
T15834 411-412 NNP denotes [
T15833 401-410 VBN denotes described
T15832 390-400 RB denotes previously
T15831 387-389 IN denotes as
T15830 377-386 VBN denotes generated
T15829 373-376 VBD denotes was
T15828 371-372 -RRB- denotes )
T15827 364-371 NNP denotes Myr-Akt
T15826 363-364 -LRB- denotes (
T15825 358-362 NNP denotes Akt1
T15824 351-357 JJ denotes active
T15823 336-350 RB denotes Constitutively
T15822 334-335 . denotes .
T15821 323-334 NN denotes necroptosis
T15820 316-322 IN denotes during
T15819 305-315 NN denotes activation
T15818 301-304 NNP denotes Akt
T15817 298-300 TO denotes to
T15816 291-297 NN denotes kinase
T15815 286-290 CD denotes RIP1
T15814 282-285 CC denotes and
T15813 274-281 NNS denotes factors
T15812 267-273 NN denotes growth
T15811 264-266 IN denotes of
T15810 251-263 NN denotes contribution
T15809 247-250 DT denotes the
T15808 236-246 VBP denotes understand
T15807 228-235 JJ denotes further
T15806 225-227 TO denotes to
T15805 219-224 NN denotes order
T15804 216-218 IN denotes in
T15803 210-215 NNP denotes K179M
T15802 203-209 JJ denotes mutant
T15801 194-202 JJ denotes inactive
T15800 180-193 RB denotes catalytically
T15799 176-179 DT denotes the
T15798 173-175 CC denotes or
T15797 171-172 -RRB- denotes )
T15796 164-171 NNP denotes Myr-Akt
T15795 163-164 -LRB- denotes (
T15794 158-162 NNP denotes Akt1
T15793 153-157 NN denotes type
T15792 148-152 JJ denotes wild
T15791 141-147 JJ denotes active
T15790 126-140 RB denotes constitutively
T15789 115-125 VBG denotes expressing
T15788 108-114 RB denotes stably
T15787 102-107 NNS denotes cells
T15786 97-101 CD denotes L929
T15785 92-96 VBD denotes used
T15784 89-91 PRP denotes We
T15783 78-88 NNPS denotes Conditions
T15782 73-77 NNP denotes Free
T15781 67-72 NNP denotes Serum
T15780 61-66 IN denotes Under
T15779 49-60 NNP denotes Necroptosis
T15778 41-48 NNP denotes Rescues
T15777 39-40 , denotes ,
T15776 36-39 NNP denotes Akt
T16123 3327-3331 IN denotes that
T16122 3316-3326 VBG denotes confirming
T16121 3314-3315 , denotes ,
T16120 3308-3314 JJ denotes mutant
T16119 3302-3307 NNP denotes K179M
T16118 3298-3301 DT denotes the
T16117 3294-3297 RB denotes not
T16116 3290-3293 CC denotes but
T16115 3288-3289 , denotes ,
T16114 3281-3288 NNP denotes Myr-Akt
T16113 3278-3280 IN denotes of
T16112 3267-3277 NN denotes expression
T16111 3263-3266 DT denotes the
T16110 3258-3262 IN denotes upon
T16109 3248-3257 VBN denotes increased
T16108 3244-3247 VBD denotes was
T16107 3233-3243 NNS denotes substrates
T16106 3229-3232 NNP denotes Akt
T16105 3219-3228 VBN denotes described
T15888 708-709 , denotes ,
T15887 702-708 JJ denotes viable
T15886 697-701 VBD denotes were
T15885 689-696 NNP denotes Myr-Akt
T15884 678-688 VBG denotes expressing
T15883 672-677 NNS denotes cells
T15882 668-671 DT denotes the
T15881 663-667 IN denotes that
T15880 658-662 VB denotes note
T15879 655-657 TO denotes to
T15878 645-654 JJ denotes important
T15877 642-644 VBZ denotes is
T15876 639-641 PRP denotes It
T15875 637-638 . denotes .
T15874 633-637 JJ denotes free
T15873 627-632 NN denotes serum
T15872 621-626 IN denotes under
T15871 614-620 JJ denotes active
T15870 611-613 VBZ denotes is
T15869 606-610 WDT denotes that
T15868 602-605 NNP denotes Akt
T15867 599-601 DT denotes an
T15866 596-598 IN denotes in
T15865 586-595 VBG denotes resulting
T15864 584-585 -RRB- denotes )
T15863 582-584 NN denotes 7A
T15862 577-581 NNP denotes Fig.
T15861 576-577 -LRB- denotes (
T15860 569-575 NN denotes domain
T15859 566-568 NNP denotes PH
T15858 550-565 JJ denotes auto-inhibitory
T15857 546-549 DT denotes the
T15856 543-545 IN denotes of
T15855 534-542 NN denotes deletion
T15854 530-533 DT denotes the
T15853 527-529 IN denotes by
T31472 1892-1902 NN denotes expression
T31471 1887-1891 IN denotes Over
T31588 2524-2525 . denotes .
T31488 1986-1987 -RRB- denotes )
T31487 1985-1986 NNP denotes B
T31486 1984-1985 , denotes ,
T31485 1983-1984 DT denotes A
T31484 1982-1983 -LRB- denotes (
T31483 1980-1981 . denotes .
T31482 1970-1980 NNS denotes conditions
T31481 1965-1969 JJ denotes free
T31480 1959-1964 NN denotes serum
T31479 1953-1958 IN denotes under
T31478 1941-1952 NN denotes necroptosis
T31477 1932-1940 VBZ denotes restores
T31476 1928-1931 NNP denotes Akt
T31475 1921-1927 JJ denotes active
T31474 1906-1920 RB denotes constitutively
T31473 1903-1905 IN denotes of
T31490 1993-1998 NNS denotes cells
T31489 1988-1992 NNP denotes L929
T31627 2734-2737 NNP denotes RNA
T31626 2730-2733 CD denotes 18S
T31625 2724-2729 NN denotes mouse
T31624 2718-2723 VBG denotes using
T31623 2707-2717 VBN denotes normalized
T31622 2703-2706 CC denotes and
T31621 2695-2702 NNP denotes qRT-PCR
T31620 2692-2694 IN denotes by
T31619 2681-2691 VBN denotes determined
T31618 2676-2680 VBD denotes were
T31617 2669-2675 NNS denotes levels
T31616 2664-2668 NNP denotes mRNA
T31615 2659-2663 NNP denotes TNFα
T31614 2657-2658 . denotes .
T31613 2647-2657 NNS denotes conditions
T31612 2642-2646 JJ denotes free
T31611 2636-2641 NN denotes serum
T31610 2630-2635 IN denotes under
T31609 2627-2629 NN denotes hr
T31608 2625-2626 CD denotes 9
T31607 2621-2624 IN denotes for
T31606 2612-2620 NNP denotes zVAD.fmk
T31605 2607-2611 IN denotes with
T31604 2596-2606 VBN denotes stimulated
T31603 2591-2595 VBD denotes were
T31602 2589-2590 , denotes ,
T31601 2583-2589 NNP denotes K179KM
T31600 2575-2582 NNP denotes Myr-Akt
T31599 2571-2574 CC denotes and
T31598 2563-2570 NNP denotes Myr-Akt
T31597 2558-2562 IN denotes with
T31596 2549-2557 VBN denotes infected
T31595 2542-2548 RB denotes stably
T31594 2540-2541 , denotes ,
T31593 2535-2540 NNS denotes cells
T31592 2530-2534 NNP denotes L929
T31591 2528-2529 -RRB- denotes )
T31590 2527-2528 NNP denotes D
T31589 2526-2527 -LRB- denotes (
T31665 2918-2925 JJ denotes western
T31664 2916-2917 , denotes ,
T31663 2915-2916 -RRB- denotes )
T31662 2914-2915 NNP denotes E
T31661 2913-2914 -LRB- denotes (
T31660 2910-2912 NN denotes hr
T31659 2907-2909 CD denotes 24
T31658 2904-2906 IN denotes at
T31657 2898-2903 NN denotes assay
T31656 2888-2897 NN denotes viability
T31655 2885-2887 IN denotes by
T31654 2876-2884 VBN denotes followed
T31653 2874-2875 , denotes ,
T31652 2864-2874 NNS denotes conditions
T31651 2859-2863 JJ denotes free
T31650 2853-2858 NN denotes serum
T31649 2847-2852 IN denotes under
T31648 2838-2846 NNP denotes zVAD.fmk
T31647 2833-2837 IN denotes with
T31646 2825-2832 VBN denotes treated
T31645 2820-2824 VBD denotes were
T31644 2813-2819 NNP denotes Ser473
T31643 2809-2812 CC denotes and
T31642 2802-2808 NNP denotes Thr308
T31641 2799-2801 IN denotes of
T31640 2791-2798 NNS denotes mutants
T31639 2787-2790 NNP denotes Asp
T31638 2783-2786 CC denotes and
T31637 2779-2782 NNP denotes Ala
T31636 2775-2778 CC denotes and
T31635 2767-2774 NNP denotes Myr-Akt
T31634 2756-2766 VBG denotes expressing
T31633 2750-2755 NNS denotes cells
T31632 2745-2749 NNP denotes L929
T31631 2743-2744 -RRB- denotes )
T31630 2740-2743 NNP denotes E-G
T31629 2739-2740 -LRB- denotes (
T15775 29-35 NNP denotes Active
T15774 14-28 NNP denotes Constitutively
T15773 11-13 IN denotes of
T15772 0-10 NN denotes Expression
T16385 4783-4788 IN denotes while
T16384 4781-4782 , denotes ,
T16383 4778-4781 NNP denotes Akt
T16382 4773-4777 NN denotes type
T16381 4768-4772 JJ denotes wild
T16380 4765-4767 TO denotes to
T16379 4754-4764 JJ denotes comparable
T16378 4745-4753 NN denotes activity
T16377 4735-4744 VBD denotes displayed
T16376 4727-4734 NNS denotes mutants
T16375 4723-4726 NNP denotes Asp
T16374 4718-4722 DT denotes both
T16373 4716-4717 , denotes ,
T16372 4711-4716 NNS denotes hands
T16371 4707-4710 PRP$ denotes our
T16370 4704-4706 IN denotes In
T16369 4702-4703 . denotes .
T16368 4691-4702 NN denotes necroptosis
T16367 4684-4690 IN denotes during
T16366 4678-4683 NNS denotes sites
T16365 4673-4677 DT denotes both
T16364 4670-4672 IN denotes at
T16363 4662-4669 NNS denotes mutants
T16362 4658-4661 NNP denotes Asp
T16361 4654-4657 CC denotes and
T16360 4650-4653 NNP denotes Ala
T16359 4647-4649 IN denotes of
T16358 4640-4646 NN denotes effect
T16357 4636-4639 DT denotes the
T16356 4627-4635 VBD denotes examined
T16355 4624-4626 PRP denotes We
T16354 4622-4623 . denotes .
T16353 4621-4622 NNP denotes ]
T16352 4619-4621 CD denotes 38
T16351 4618-4619 NNP denotes [
T16350 4609-4617 NN denotes activity
T16446 5110-5119 VBD denotes displayed
T16445 5108-5109 , denotes ,
T16444 5104-5108 NNP denotes zVAD
T16443 5101-5103 IN denotes of
T16442 5092-5100 NN denotes addition
T16441 5088-5091 DT denotes the
T16440 5082-5087 IN denotes after
T16439 5075-5081 CD denotes Thr308
T16438 5072-5074 IN denotes on
T16437 5057-5071 VBN denotes phosphorylated
T16436 5053-5056 VBD denotes was
T16435 5047-5052 WDT denotes which
T16434 5045-5046 , denotes ,
T16433 5039-5045 JJ denotes mutant
T16432 5033-5038 NNP denotes S473D
T16431 5029-5032 DT denotes the
T16430 5027-5028 , denotes ,
T16429 5019-5027 VBN denotes expected
T16428 5016-5018 IN denotes As
T16427 5014-5015 . denotes .
T16426 5013-5014 -RRB- denotes )
T16425 5012-5013 NNP denotes G
T16424 5011-5012 , denotes ,
T16423 5010-5011 NN denotes F
T16422 5009-5010 , denotes ,
T16421 5007-5009 NNP denotes 7E
T16420 5002-5006 NNP denotes Fig.
T16419 5001-5002 -LRB- denotes (
T16418 4993-5000 NNS denotes changes
T16417 4981-4992 JJ denotes necroptotic
T16416 4973-4980 VB denotes promote
T16415 4970-4972 TO denotes to
T16414 4962-4969 NN denotes ability
T16413 4956-4961 PRP$ denotes their
T16412 4953-4955 IN denotes in
T16411 4941-4952 NNS denotes differences
T16410 4935-4940 JJ denotes major
T16409 4925-4934 VBD denotes displayed
T16408 4917-4924 NNS denotes mutants
T16407 4910-4916 NNP denotes Ser473
T16406 4906-4909 CC denotes and
R10244 T15772 T15776 nmod Expression,Akt
R10245 T15773 T15772 prep of,Expression
R10246 T15774 T15773 pobj Constitutively,of
R10247 T15775 T15776 compound Active,Akt
R10248 T15776 T15776 ROOT Akt,Akt
R10249 T15777 T15776 punct ",",Akt
R10250 T15778 T15779 compound Rescues,Necroptosis
R10251 T15779 T15776 appos Necroptosis,Akt
R10252 T15780 T15785 prep Under,used
R10253 T15781 T15783 compound Serum,Conditions
R10254 T15782 T15783 compound Free,Conditions
R10255 T15783 T15780 pobj Conditions,Under
R10256 T15784 T15785 nsubj We,used
R10257 T15785 T15785 ROOT used,used
R10258 T15786 T15787 nummod L929,cells
R10259 T15787 T15785 dobj cells,used
R10260 T15788 T15789 advmod stably,expressing
R10261 T15789 T15785 advcl expressing,used
R10262 T15790 T15791 advmod constitutively,active
R10263 T15791 T15793 amod active,type
R10264 T15792 T15793 amod wild,type
R10265 T15793 T15789 dobj type,expressing
R10266 T15794 T15793 appos Akt1,type
R10267 T15795 T15796 punct (,Myr-Akt
R10268 T15796 T15794 appos Myr-Akt,Akt1
R10269 T15797 T15796 punct ),Myr-Akt
R10270 T15798 T15794 cc or,Akt1
R10271 T15799 T15803 det the,K179M
R10272 T15800 T15801 advmod catalytically,inactive
R10273 T15801 T15803 amod inactive,K179M
R10274 T15802 T15803 compound mutant,K179M
R10275 T15803 T15794 conj K179M,Akt1
R10276 T15804 T15789 prep in,expressing
R10277 T15805 T15804 pobj order,in
R10278 T15806 T15808 aux to,understand
R10279 T15807 T15808 advmod further,understand
R10280 T15808 T15805 acl understand,order
R10281 T15809 T15810 det the,contribution
R10282 T15810 T15808 dobj contribution,understand
R10283 T15811 T15810 prep of,contribution
R10284 T15812 T15813 compound growth,factors
R10285 T15813 T15811 pobj factors,of
R10286 T15814 T15813 cc and,factors
R10287 T15815 T15816 nummod RIP1,kinase
R10288 T15816 T15813 conj kinase,factors
R10289 T15817 T15816 prep to,kinase
R10290 T15818 T15819 compound Akt,activation
R10291 T15819 T15817 pobj activation,to
R10292 T15820 T15816 prep during,kinase
R10293 T15821 T15820 pobj necroptosis,during
R10294 T15822 T15785 punct .,used
R10295 T15823 T15824 advmod Constitutively,active
R10296 T15824 T15825 amod active,Akt1
R10297 T15825 T15830 nsubjpass Akt1,generated
R10298 T15826 T15827 punct (,Myr-Akt
R10299 T15827 T15825 appos Myr-Akt,Akt1
R10300 T15828 T15825 punct ),Akt1
R10301 T15829 T15830 auxpass was,generated
R10302 T15830 T15830 ROOT generated,generated
R10303 T15831 T15833 mark as,described
R10304 T15832 T15833 advmod previously,described
R10305 T15833 T15830 advcl described,generated
R10306 T15834 T15836 nmod [,]
R10307 T15835 T15836 nummod 37,]
R10308 T15836 T15833 dobj ],described
R10309 T15837 T15833 prep by,described
R10310 T15838 T15839 det the,addition
R10311 T15839 T15837 pobj addition,by
R10312 T15840 T15839 prep of,addition
R10313 T15841 T15843 det a,signal
R10314 T15842 T15843 compound myristoylation,signal
R10315 T15843 T15840 pobj signal,of
R10316 T15844 T15845 nsubj which,provides
R10317 T15845 T15843 relcl provides,signal
R10318 T15846 T15847 amod constitutive,localization
R10319 T15847 T15845 dobj localization,provides
R10320 T15848 T15845 dative to,provides
R10321 T15849 T15851 det the,membrane
R10322 T15850 T15851 compound plasma,membrane
R10323 T15851 T15848 pobj membrane,to
R10324 T15852 T15845 cc and,provides
R10325 T15853 T15843 prep by,signal
R10326 T15854 T15855 det the,deletion
R10327 T15855 T15853 pobj deletion,by
R10328 T15856 T15855 prep of,deletion
R10329 T15857 T15860 det the,domain
R10330 T15858 T15860 amod auto-inhibitory,domain
R10331 T15859 T15860 compound PH,domain
R10332 T15860 T15856 pobj domain,of
R10333 T15861 T15860 punct (,domain
R10334 T15862 T15863 compound Fig.,7A
R10335 T15863 T15860 appos 7A,domain
R10336 T15864 T15860 punct ),domain
R10337 T15865 T15833 advcl resulting,described
R10338 T15866 T15865 prep in,resulting
R10339 T15867 T15868 det an,Akt
R10340 T15868 T15866 pobj Akt,in
R10341 T15869 T15870 nsubj that,is
R10342 T15870 T15868 relcl is,Akt
R10343 T15871 T15870 acomp active,is
R10344 T15872 T15870 prep under,is
R10345 T15873 T15874 npadvmod serum,free
R10346 T15874 T15870 acomp free,is
R10347 T15875 T15830 punct .,generated
R10348 T15876 T15877 nsubj It,is
R10349 T15877 T15877 ROOT is,is
R10350 T15878 T15877 acomp important,is
R10351 T15879 T15880 aux to,note
R10352 T15880 T15877 xcomp note,is
R10353 T15881 T15886 mark that,were
R10354 T15882 T15883 det the,cells
R10355 T15883 T15886 nsubj cells,were
R10356 T15884 T15883 acl expressing,cells
R10357 T15885 T15884 dobj Myr-Akt,expressing
R10358 T15886 T15880 ccomp were,note
R10359 T15887 T15886 acomp viable,were
R10360 T15888 T15889 punct ",",grew
R10361 T15889 T15886 conj grew,were
R10362 T15890 T15889 prep in,grew
R10363 T15891 T15892 det a,manner
R10364 T15892 T15890 pobj manner,in
R10365 T15893 T15892 amod indistinguishable,manner
R10366 T15894 T15893 prep from,indistinguishable
R10367 T15895 T15899 det the,cells
R10368 T15896 T15899 amod empty,cells
R10369 T15897 T15898 compound vector,control
R10370 T15898 T15899 compound control,cells
R10371 T15899 T15894 pobj cells,from
R10372 T15900 T15889 punct ",",grew
R10373 T15901 T15889 cc and,grew
R10374 T15902 T15904 auxpass were,triggered
R10375 T15903 T15904 neg not,triggered
R10376 T15904 T15889 conj triggered,grew
R10377 T15905 T15906 aux to,induce
R10378 T15906 T15904 xcomp induce,triggered
R10379 T15907 T15906 dobj necroptosis,induce
R10380 T15908 T15906 prep by,induce
R10381 T15909 T15910 compound serum,starvation
R10382 T15910 T15908 pobj starvation,by
R10383 T15911 T15910 punct (,starvation
R10384 T15912 T15913 compound Fig.,7B
R10385 T15913 T15910 appos 7B,starvation
R10386 T15914 T15910 punct ),starvation
R10387 T15915 T15877 punct .,is
R10388 T15916 T15917 nsubj This,indicates
R10389 T15917 T15917 ROOT indicates,indicates
R10390 T15918 T15922 mark that,is
R10391 T15919 T15920 amod active,Akt
R10392 T15920 T15922 nsubj Akt,is
R10393 T15921 T15920 advmod alone,Akt
R10394 T15922 T15917 ccomp is,indicates
R10395 T15923 T15922 neg not,is
R10396 T15924 T15922 acomp sufficient,is
R10397 T15925 T15926 aux to,induce
R10398 T15926 T15924 xcomp induce,sufficient
R10399 T15927 T15929 amod necroptotic,death
R10400 T15928 T15929 compound cell,death
R10401 T15929 T15926 dobj death,induce
R10402 T15930 T15917 punct .,indicates
R10403 T15931 T15941 prep Under,mutant
R10404 T15932 T15934 amod serum,conditions
R10405 T15933 T15934 amod free,conditions
R10406 T15934 T15931 pobj conditions,Under
R10407 T15935 T15941 dep Myr-Akt,mutant
R10408 T15936 T15941 punct ",",mutant
R10409 T15937 T15941 cc but,mutant
R10410 T15938 T15941 neg not,mutant
R10411 T15939 T15941 det the,mutant
R10412 T15940 T15941 compound K179M,mutant
R10413 T15941 T15941 ROOT mutant,mutant
R10414 T15942 T15946 punct ",",necroptosis
R10415 T15943 T15944 advmod fully,restored
R10416 T15944 T15946 amod restored,necroptosis
R10417 T15945 T15946 amod zVAD.fmk-induced,necroptosis
R10418 T15946 T15941 appos necroptosis,mutant
R10419 T15947 T15949 punct (,7A
R10420 T15948 T15949 compound Fig.,7A
R10421 T15949 T15946 appos 7A,necroptosis
R10422 T15950 T15949 punct ",",7A
R10423 T15951 T15949 appos B,7A
R10424 T15952 T15949 punct ),7A
R10425 T15953 T15941 punct .,mutant
R10426 T15954 T15955 nsubj Nec-1,prevented
R10427 T15955 T15955 ROOT prevented,prevented
R10428 T15956 T15960 det both,death
R10429 T15957 T15960 nmod Myr-Akt,death
R10430 T15958 T15960 amod dependent,death
R10431 T15959 T15960 compound cell,death
R10432 T15960 T15955 dobj death,prevented
R10433 T15961 T15960 cc and,death
R10434 T15962 T15965 det the,increase
R10435 T15963 T15965 amod necroptosis-specific,increase
R10436 T15964 T15965 amod delayed,increase
R10437 T15965 T15960 conj increase,death
R10438 T15966 T15965 prep in,increase
R10439 T15967 T15969 compound Akt,phosphorylation
R10440 T15968 T15969 compound Thr308,phosphorylation
R10441 T15969 T15966 pobj phosphorylation,in
R10442 T15970 T15972 punct (,7B
R10443 T15971 T15972 compound Fig.,7B
R10444 T15972 T15969 appos 7B,phosphorylation
R10445 T15973 T15972 punct ",",7B
R10446 T15974 T15972 appos C,7B
R10447 T15975 T15972 punct ),7B
R10448 T15976 T15955 punct .,prevented
R10449 T15977 T15979 nsubj Myr-Akt,allowed
R10450 T15978 T15979 advmod also,allowed
R10451 T15979 T15979 ROOT allowed,allowed
R10452 T15980 T15982 amod other,events
R10453 T15981 T15982 amod zVAD.fmk-dependent,events
R10454 T15982 T16005 nsubj events,occur
R10455 T15983 T15982 punct ",",events
R10456 T15984 T15982 prep including,events
R10457 T15985 T15984 pobj activation,including
R10458 T15986 T15985 prep of,activation
R10459 T15987 T15990 nmod JNK,phosphorylation
R10460 T15988 T15987 cc and,JNK
R10461 T15989 T15990 amod c-Jun,phosphorylation
R10462 T15990 T15986 pobj phosphorylation,of
R10463 T15991 T15993 punct (,7C
R10464 T15992 T15993 compound Fig.,7C
R10465 T15993 T15990 appos 7C,phosphorylation
R10466 T15994 T15993 punct ),7C
R10467 T15995 T15990 cc and,phosphorylation
R10468 T15996 T15990 conj upregulation,phosphorylation
R10469 T15997 T15990 prep of,phosphorylation
R10470 T15998 T15999 compound TNFα,mRNA
R10471 T15999 T15997 pobj mRNA,of
R10472 T16000 T15999 punct (,mRNA
R10473 T16001 T16002 compound Fig.,7D
R10474 T16002 T15999 appos 7D,mRNA
R10475 T16003 T15999 punct ),mRNA
R10476 T16004 T16005 aux to,occur
R10477 T16005 T15979 ccomp occur,allowed
R10478 T16006 T16005 prep under,occur
R10479 T16007 T16009 amod serum,conditions
R10480 T16008 T16009 amod free,conditions
R10481 T16009 T16006 pobj conditions,under
R10482 T16010 T15979 punct ",",allowed
R10483 T16011 T15979 advcl confirming,allowed
R10484 T16012 T16014 det an,role
R10485 T16013 T16014 amod important,role
R10486 T16014 T16011 dobj role,confirming
R10487 T16015 T16014 prep for,role
R10488 T16016 T16015 pobj Akt,for
R10489 T16017 T16014 prep at,role
R10490 T16018 T16019 det the,apex
R10491 T16019 T16017 pobj apex,at
R10492 T16020 T16019 prep of,apex
R10493 T16021 T16022 amod necroptotic,signaling
R10494 T16022 T16020 pobj signaling,of
R10495 T16023 T15979 punct .,allowed
R10496 T16024 T16025 det These,data
R10497 T16025 T16026 nsubj data,demonstrated
R10498 T16026 T16026 ROOT demonstrated,demonstrated
R10499 T16027 T16036 mark that,is
R10500 T16028 T16029 det the,presence
R10501 T16029 T16036 nsubj presence,is
R10502 T16030 T16029 prep of,presence
R10503 T16031 T16035 amod active,Akt
R10504 T16032 T16031 cc and,active
R10505 T16033 T16031 conj membrane,active
R10506 T16034 T16035 amod localized,Akt
R10507 T16035 T16030 pobj Akt,of
R10508 T16036 T16026 ccomp is,demonstrated
R10509 T16037 T16036 acomp sufficient,is
R10510 T16038 T16039 aux to,uncouple
R10511 T16039 T16037 xcomp uncouple,sufficient
R10512 T16040 T16041 compound Akt,activation
R10513 T16041 T16039 dobj activation,uncouple
R10514 T16042 T16039 prep during,uncouple
R10515 T16043 T16042 pobj necroptosis,during
R10516 T16044 T16043 prep from,necroptosis
R10517 T16045 T16046 compound growth,factor
R10518 T16046 T16044 pobj factor,from
R10519 T16047 T16036 advcl signaling,is
R10520 T16048 T16026 punct .,demonstrated
R10521 T16049 T16050 nummod RIP1,kinase
R10522 T16050 T16051 nsubj kinase,was
R10523 T16051 T16051 ROOT was,was
R10524 T16052 T16051 advmod still,was
R10525 T16053 T16051 acomp able,was
R10526 T16054 T16055 aux to,regulate
R10527 T16055 T16053 xcomp regulate,able
R10528 T16056 T16057 compound Akt,activation
R10529 T16057 T16055 dobj activation,regulate
R10530 T16058 T16055 prep during,regulate
R10531 T16059 T16058 pobj necroptosis,during
R10532 T16060 T16051 punct ",",was
R10533 T16061 T16051 advcl suggesting,was
R10534 T16062 T16068 mark that,provide
R10535 T16063 T16064 compound growth,factors
R10536 T16064 T16068 nsubj factors,provide
R10537 T16065 T16064 cc and,factors
R10538 T16066 T16067 nummod RIP1,kinase
R10539 T16067 T16064 conj kinase,factors
R10540 T16068 T16061 ccomp provide,suggesting
R10541 T16069 T16071 nummod two,inputs
R10542 T16070 T16071 amod independent,inputs
R10543 T16071 T16068 dobj inputs,provide
R10544 T16072 T16071 acl required,inputs
R10545 T16073 T16072 prep for,required
R10546 T16074 T16075 compound Akt,changes
R10547 T16075 T16073 pobj changes,for
R10548 T16076 T16075 prep during,changes
R10549 T16077 T16076 pobj necroptosis,during
R10550 T16078 T16051 punct .,was
R10556 T16084 T16083 pobj Myr-Akt,of
R10557 T16085 T16087 prep during,increased
R10558 T16086 T16085 pobj necroptosis,during
R10559 T16087 T16087 ROOT increased,increased
R10560 T16088 T16089 compound Myr-Akt,activity
R10561 T16089 T16087 dobj activity,increased
R10562 T16090 T16092 mark as,did
R10563 T16091 T16092 nsubj it,did
R10564 T16092 T16087 advcl did,increased
R10565 T16093 T16092 prep with,did
R10566 T16094 T16095 compound endogenous,Akt
R10567 T16095 T16093 pobj Akt,with
R10568 T16096 T16097 punct (,Fig.
R10569 T16097 T16095 appos Fig.,Akt
R10570 T16098 T16097 nummod 5,Fig.
R10571 T16099 T16095 punct ),Akt
R10572 T16100 T16087 punct .,increased
R10573 T16101 T16109 nsubjpass Phosphorylation,increased
R10574 T16102 T16101 prep of,Phosphorylation
R10575 T16103 T16107 amod many,substrates
R10576 T16104 T16105 advmod previously,described
R10577 T16105 T16107 amod described,substrates
R10578 T16106 T16107 compound Akt,substrates
R10579 T16107 T16102 pobj substrates,of
R10580 T16108 T16109 auxpass was,increased
R10581 T16109 T16109 ROOT increased,increased
R10582 T16110 T16109 prep upon,increased
R10583 T16111 T16112 det the,expression
R10584 T16112 T16110 pobj expression,upon
R10585 T16113 T16112 prep of,expression
R10586 T16114 T16113 pobj Myr-Akt,of
R10587 T16115 T16109 punct ",",increased
R10588 T16116 T16109 cc but,increased
R10589 T16117 T16120 neg not,mutant
R10590 T16118 T16120 det the,mutant
R10591 T16119 T16120 compound K179M,mutant
R10592 T16120 T16128 amod mutant,substrates
R10593 T16121 T16120 punct ",",mutant
R10594 T16122 T16120 acl confirming,mutant
R10595 T16123 T16126 mark that,are
R10596 T16124 T16125 det these,molecules
R10597 T16125 T16126 nsubj molecules,are
R10598 T16126 T16122 ccomp are,confirming
R10599 T16127 T16128 compound Akt,substrates
R10600 T16128 T16109 conj substrates,increased
R10601 T16129 T16128 prep in,substrates
R10602 T16130 T16131 nummod L929,cells
R10603 T16131 T16129 pobj cells,in
R10604 T16132 T16128 punct (,substrates
R10605 T16133 T16134 compound Fig.,7C
R10606 T16134 T16128 appos 7C,substrates
R10607 T16135 T16128 punct ),substrates
R10608 T16136 T16109 punct .,increased
R10609 T16137 T16138 det The,effect
R10610 T16138 T16144 nsubj effect,varied
R10611 T16139 T16138 prep of,effect
R10612 T16140 T16139 pobj zVAD.fmk,of
R10613 T16141 T16138 prep on,effect
R10614 T16142 T16143 poss their,phosphorylation
R10615 T16143 T16141 pobj phosphorylation,on
R10616 T16144 T16144 ROOT varied,varied
R10617 T16145 T16144 punct ",",varied
R10618 T16146 T16147 amod likely,due
R10619 T16147 T16148 amod due,to
R10620 T16148 T16144 prep to,varied
R10621 T16149 T16152 det the,activity
R10622 T16150 T16152 amod increased,activity
R10623 T16151 T16152 compound basal,activity
R10624 T16152 T16148 pobj activity,to
R10625 T16153 T16152 prep of,activity
R10626 T16154 T16153 pobj Myr-Akt,of
R10627 T16155 T16144 punct .,varied
R10628 T16156 T16157 det Some,substrates
R10629 T16157 T16170 nsubjpass substrates,phosphorylated
R10630 T16158 T16157 punct ",",substrates
R10631 T16159 T16157 prep including,substrates
R10632 T16160 T16159 pobj p70S6K,including
R10633 T16161 T16160 punct ",",p70S6K
R10634 T16162 T16160 conj S6,p70S6K
R10635 T16163 T16162 punct ",",S6
R10636 T16164 T16162 conj GSK-3,S6
R10637 T16165 T16164 cc and,GSK-3
R10638 T16166 T16164 conj FoxO4,GSK-3
R10639 T16167 T16170 punct ",",phosphorylated
R10640 T16168 T16170 auxpass were,phosphorylated
R10641 T16169 T16170 advmod fully,phosphorylated
R10642 T16170 T16170 ROOT phosphorylated,phosphorylated
R10643 T16171 T16172 advmod even,in
R10644 T16172 T16170 prep in,phosphorylated
R10645 T16173 T16174 det the,absence
R10646 T16174 T16172 pobj absence,in
R10647 T16175 T16174 prep of,absence
R10648 T16176 T16175 pobj zVAD.fmk,of
R10649 T16177 T16170 punct .,phosphorylated
R10650 T16178 T16190 prep On,increased
R10651 T16179 T16181 det the,hand
R10652 T16180 T16181 amod other,hand
R10653 T16181 T16178 pobj hand,On
R10654 T16182 T16190 punct ",",increased
R10655 T16183 T16190 nsubjpass phosphorylation,increased
R10656 T16184 T16183 prep of,phosphorylation
R10657 T16185 T16184 pobj FoxO1,of
R10658 T16186 T16185 cc and,FoxO1
R10659 T16187 T16185 conj MDM2,FoxO1
R10660 T16188 T16190 auxpass was,increased
R10661 T16189 T16190 advmod significantly,increased
R10662 T16190 T16190 ROOT increased,increased
R10663 T16191 T16190 prep in,increased
R10664 T16192 T16193 det the,presence
R10665 T16253 T16259 mark that,required
R10666 T16193 T16191 pobj presence,in
R10667 T16254 T16255 compound membrane,localization
R10668 T16194 T16193 prep of,presence
R10669 T16255 T16259 nsubjpass localization,required
R10670 T16256 T16255 prep of,localization
R10671 T16195 T16194 pobj zVAD.fmk,of
R10672 T16257 T16256 pobj Akt,of
R10673 T16258 T16259 auxpass is,required
R10674 T16196 T16190 punct ",",increased
R10675 T16259 T16252 ccomp required,found
R10676 T16197 T16190 advcl indicating,increased
R10677 T16198 T16205 mark that,promoted
R10678 T16260 T16252 punct .,found
R10679 T16261 T16262 amod Full,length
R10680 T16262 T16263 compound length,Akt
R10681 T16199 T16201 amod necroptotic,phosphorylation
R10682 T16263 T16278 nsubj Akt,support
R10683 T16264 T16263 cc or,Akt
R10684 T16265 T16266 det a,mutant
R10685 T16200 T16201 compound Thr308,phosphorylation
R10686 T16266 T16263 conj mutant,Akt
R10687 T16267 T16263 acl lacking,Akt
R10688 T16268 T16271 preconj both,domain
R10689 T16201 T16205 nsubj phosphorylation,promoted
R10690 T16269 T16271 det the,domain
R10691 T16270 T16271 compound PH,domain
R10692 T16202 T16201 prep of,phosphorylation
R10693 T16271 T16267 dobj domain,lacking
R10694 T16272 T16271 cc and,domain
R10695 T16203 T16202 pobj Myr-Akt,of
R10696 T16273 T16275 det the,tag
R10697 T16274 T16275 compound Myr,tag
R10698 T16275 T16271 conj tag,domain
R10699 T16204 T16205 advmod still,promoted
R10700 T16276 T16278 aux did,support
R10701 T16277 T16278 neg not,support
R10702 T16278 T16278 ROOT support,support
R10703 T16205 T16197 ccomp promoted,indicating
R10704 T16279 T16280 det the,activation
R10705 T16280 T16278 dobj activation,support
R10706 T16281 T16280 prep of,activation
R10707 T16206 T16207 poss its,activity
R10708 T16282 T16283 compound cell,death
R10709 T16283 T16281 pobj death,of
R10710 T16284 T16280 cc or,activation
R10711 T16285 T16287 amod increased,phosphorylation
R10712 T16286 T16287 amod Thr308,phosphorylation
R10713 T16287 T16280 conj phosphorylation,activation
R10714 T16207 T16205 dobj activity,promoted
R10715 T16288 T16278 prep following,support
R10716 T16289 T16290 compound zVAD.fmk,addition
R10717 T16290 T16288 pobj addition,following
R10718 T16208 T16190 punct .,increased
R10719 T16291 T16290 prep under,addition
R10720 T16292 T16293 npadvmod serum,free
R10721 T16293 T16294 amod free,conditions
R10722 T16209 T16232 prep Under,expressed
R10723 T16294 T16291 pobj conditions,under
R10724 T16295 T16278 punct (,support
R10725 T16296 T16278 dobj Fig,support
R10726 T16297 T16296 punct .,Fig
R10727 T16210 T16212 nmod serum,conditions
R10728 T16298 T16298 ROOT S8A,S8A
R10729 T16299 T16300 punct ",",B
R10730 T16211 T16212 amod free,conditions
R10731 T16300 T16298 appos B,S8A
R10732 T16301 T16298 punct ),S8A
R10733 T16302 T16298 punct .,S8A
R10734 T16303 T16306 advmod Second,found
R10735 T16212 T16209 pobj conditions,Under
R10736 T16304 T16306 punct ",",found
R10737 T16305 T16306 nsubj we,found
R10738 T16213 T16216 det all,events
R10739 T16306 T16306 ROOT found,found
R10740 T16214 T16216 amod zVAD.fmk-induced,events
R10741 T16215 T16216 amod downstream,events
R10742 T16307 T16311 det a,role
R10743 T16308 T16311 amod specific,role
R10744 T16216 T16232 nsubj events,expressed
R10745 T16309 T16308 cc and,specific
R10746 T16310 T16308 conj critical,specific
R10747 T16217 T16219 punct (,death
R10748 T16311 T16306 dobj role,found
R10749 T16312 T16311 prep for,role
R10750 T16218 T16219 compound cell,death
R10751 T16313 T16314 compound Thr308,phosphorylation
R10752 T16314 T16312 pobj phosphorylation,for
R10753 T16315 T16314 prep in,phosphorylation
R10754 T16219 T16216 dobj death,events
R10755 T16316 T16317 det the,regulation
R10756 T16317 T16315 pobj regulation,in
R10757 T16318 T16317 prep of,regulation
R10758 T16319 T16321 det the,functions
R10759 T16320 T16321 amod necroptotic,functions
R10760 T16220 T16216 punct ",",events
R10761 T16321 T16318 pobj functions,of
R10762 T16322 T16321 prep of,functions
R10763 T16323 T16322 pobj Akt,of
R10764 T16221 T16222 compound JNK,activation
R10765 T16324 T16306 punct .,found
R10766 T16325 T16328 nsubjpass It,reported
R10767 T16326 T16328 aux has,reported
R10768 T16222 T16225 nmod activation,production
R10769 T16327 T16328 auxpass been,reported
R10770 T16328 T16328 ROOT reported,reported
R10771 T16329 T16336 mark that,cause
R10772 T16223 T16225 punct ",",production
R10773 T16330 T16331 compound Ala,mutations
R10774 T16331 T16336 nsubj mutations,cause
R10775 T16332 T16331 prep at,mutations
R10776 T16224 T16225 compound TNFα,production
R10777 T16333 T16332 pobj Thr308,at
R10778 T16334 T16333 cc and,Thr308
R10779 T16335 T16333 conj Ser473,Thr308
R10780 T16225 T16228 nsubjpass production,dependent
R10781 T16336 T16328 ccomp cause,reported
R10782 T16337 T16338 det a,reduction
R10783 T16338 T16336 dobj reduction,cause
R10784 T16226 T16225 punct ),production
R10785 T16227 T16228 auxpass were,dependent
R10786 T16339 T16338 prep in,reduction
R10787 T16228 T16216 advcl dependent,events
R10788 T16340 T16342 det the,activity
R10789 T16229 T16228 prep on,dependent
R10790 T16341 T16342 amod catalytic,activity
R10791 T16230 T16231 det the,over
R10792 T16231 T16229 pobj over,on
R10793 T16342 T16339 pobj activity,in
R10794 T16232 T16232 ROOT expressed,expressed
R10795 T16343 T16342 prep of,activity
R10796 T16233 T16232 dobj Myr-Akt,expressed
R10797 T16234 T16232 punct .,expressed
R10798 T16344 T16343 pobj Akt,of
R10799 T16235 T16236 nsubj This,allowed
R10800 T16345 T16336 punct ",",cause
R10801 T16236 T16236 ROOT allowed,allowed
R10802 T16346 T16349 mark while,increase
R10803 T16347 T16348 amod Asp,mutants
R10804 T16237 T16239 nsubj us,examine
R10805 T16348 T16349 nsubj mutants,increase
R10806 T16349 T16336 advcl increase,cause
R10807 T16238 T16239 aux to,examine
R10808 T16239 T16236 ccomp examine,allowed
R10809 T16350 T16349 dobj activity,increase
R10810 T16240 T16241 det the,effects
R10811 T16351 T16353 nmod [,]
R10812 T16352 T16353 nummod 38,]
R10813 T16241 T16239 dobj effects,examine
R10814 T16353 T16350 appos ],activity
R10815 T16354 T16328 punct .,reported
R10816 T16242 T16241 prep of,effects
R10817 T16355 T16356 nsubj We,examined
R10818 T16356 T16356 ROOT examined,examined
R10819 T16243 T16245 amod other,mutations
R10820 T16357 T16358 det the,effect
R10821 T16358 T16356 dobj effect,examined
R10822 T16244 T16245 compound Akt,mutations
R10823 T16359 T16358 prep of,effect
R10824 T16360 T16359 pobj Ala,of
R10825 T16361 T16360 cc and,Ala
R10826 T16245 T16242 pobj mutations,of
R10827 T16362 T16360 conj Asp,Ala
R10828 T16363 T16359 pobj mutants,of
R10829 T16364 T16363 prep at,mutants
R10830 T16246 T16245 prep on,mutations
R10831 T16365 T16366 det both,sites
R10832 T16366 T16364 pobj sites,at
R10833 T16247 T16246 pobj necroptosis,on
R10834 T16367 T16356 prep during,examined
R10835 T16368 T16367 pobj necroptosis,during
R10836 T16369 T16356 punct .,examined
R10837 T16370 T16377 prep In,displayed
R10838 T16248 T16236 punct .,allowed
R10839 T16371 T16372 poss our,hands
R10840 T16372 T16370 pobj hands,In
R10841 T16249 T16252 advmod First,found
R10842 T16373 T16377 punct ",",displayed
R10843 T16374 T16376 det both,mutants
R10844 T16375 T16376 compound Asp,mutants
R10845 T16250 T16252 punct ",",found
R10846 T16376 T16377 nsubj mutants,displayed
R10847 T16377 T16377 ROOT displayed,displayed
R10848 T16378 T16377 dobj activity,displayed
R10849 T16251 T16252 nsubj we,found
R10850 T16379 T16378 amod comparable,activity
R10851 T16380 T16383 prep to,Akt
R10852 T16252 T16252 ROOT found,found
R10853 T16381 T16382 amod wild,type
R10854 T16382 T16380 pobj type,to
R10855 T16383 T16377 oprd Akt,displayed
R10856 T16406 T16405 cc and,Thr308
R10857 T16384 T16377 punct ",",displayed
R10858 T16385 T16389 mark while,displayed
R10859 T16386 T16388 det both,mutants
R10860 T16387 T16388 compound Ala,mutants
R10861 T16407 T16405 conj Ser473,Thr308
R10862 T16388 T16389 nsubj mutants,displayed
R10863 T16389 T16377 advcl displayed,displayed
R10864 T16390 T16391 amod comparable,decreases
R10865 T16391 T16389 dobj decreases,displayed
R10866 T16408 T16409 nsubj mutants,displayed
R10867 T16392 T16389 prep in,displayed
R10868 T16393 T16392 pobj activity,in
R10869 T16409 T16409 ROOT displayed,displayed
R10870 T16394 T16395 punct (,Fig
R10871 T16395 T16393 appos Fig,activity
R10872 T16396 T16377 punct .,displayed
R10873 T16397 T16397 ROOT S8C,S8C
R10874 T16410 T16411 amod major,differences
R10875 T16398 T16397 punct ),S8C
R10876 T16399 T16397 punct .,S8C
R10877 T16411 T16409 dobj differences,displayed
R10878 T16400 T16409 prep Despite,displayed
R10879 T16401 T16403 amod similar,activities
R10880 T16402 T16403 amod catalytic,activities
R10881 T16412 T16411 prep in,differences
R10882 T16403 T16400 pobj activities,Despite
R10883 T16404 T16409 punct ",",displayed
R10884 T16413 T16414 poss their,ability
R10885 T16405 T16408 nmod Thr308,mutants
R10886 T16414 T16412 pobj ability,in
R10887 T16415 T16416 aux to,promote
R10888 T16416 T16414 acl promote,ability
R10889 T16417 T16418 amod necroptotic,changes
R10890 T16447 T16448 advmod only,slightly
R10891 T16418 T16416 dobj changes,promote
R10892 T16448 T16449 advmod slightly,reduced
R10893 T16449 T16450 amod reduced,activity
R10894 T16419 T16421 punct (,7E
R10895 T16450 T16446 dobj activity,displayed
R10896 T16451 T16446 punct ",",displayed
R10897 T16452 T16454 mark while,was
R10898 T16420 T16421 compound Fig.,7E
R10899 T16453 T16454 nsubj S473A,was
R10900 T16454 T16446 advcl was,displayed
R10901 T16421 T16425 dep 7E,G
R10902 T16455 T16457 advmod significantly,active
R10903 T16456 T16457 advmod less,active
R10904 T16457 T16454 acomp active,was
R10905 T16458 T16457 prep in,active
R10906 T16422 T16421 punct ",",7E
R10907 T16459 T16460 det all,aspects
R10908 T16460 T16458 pobj aspects,in
R10909 T16461 T16460 prep of,aspects
R10910 T16462 T16461 pobj necroptosis,of
R10911 T16463 T16437 punct .,phosphorylated
R10912 T16423 T16425 advmod F,G
R10913 T16464 T16465 nsubj S473A,was
R10914 T16465 T16465 ROOT was,was
R10915 T16466 T16465 acomp unable,was
R10916 T16424 T16425 punct ",",G
R10917 T16467 T16470 aux to,phosphorylated
R10918 T16468 T16470 auxpass be,phosphorylated
R10919 T16469 T16470 advmod efficiently,phosphorylated
R10920 T16425 T16416 dep G,promote
R10921 T16470 T16466 xcomp phosphorylated,unable
R10922 T16471 T16470 prep on,phosphorylated
R10923 T16472 T16481 punct Thr308,mutated
R10924 T16426 T16409 punct ),displayed
R10925 T16473 T16474 advmod possibly,due
R10926 T16427 T16409 punct .,displayed
R10927 T16474 T16481 prep due,mutated
R10928 T16475 T16474 pcomp to,due
R10929 T16428 T16429 mark As,expected
R10930 T16476 T16477 det the,inability
R10931 T16477 T16481 nsubj inability,mutated
R10932 T16478 T16477 prep of,inability
R10933 T16429 T16437 advcl expected,phosphorylated
R10934 T16479 T16480 det the,Ala
R10935 T16480 T16478 pobj Ala,of
R10936 T16481 T16481 ROOT mutated,mutated
R10937 T16482 T16483 nummod 473,site
R10938 T16430 T16437 punct ",",phosphorylated
R10939 T16483 T16481 dobj site,mutated
R10940 T16484 T16486 aux to,phosphorylated
R10941 T16431 T16433 det the,mutant
R10942 T16485 T16486 auxpass be,phosphorylated
R10943 T16486 T16483 relcl phosphorylated,site
R10944 T16487 T16481 cc and,mutated
R10945 T16488 T16481 conj provide,mutated
R10946 T16432 T16433 compound S473D,mutant
R10947 T16489 T16491 det a,site
R10948 T16490 T16491 compound docking,site
R10949 T16433 T16437 nsubjpass mutant,phosphorylated
R10950 T16491 T16488 dobj site,provide
R10951 T16492 T16495 mark for,phosphorylate
R10952 T16493 T16495 nsubj PDK1,phosphorylate
R10953 T16434 T16433 punct ",",mutant
R10954 T16494 T16495 aux to,phosphorylate
R10955 T16495 T16491 advcl phosphorylate,site
R10956 T16496 T16497 compound Thr308,[
R10957 T16435 T16436 nsubj which,was
R10958 T16497 T16495 dobj [,phosphorylate
R10959 T16498 T16499 nummod 39,]
R10960 T16499 T16497 appos ],[
R10961 T16500 T16481 punct .,mutated
R10962 T16501 T16510 advmod Strikingly,were
R10963 T16436 T16437 auxpass was,phosphorylated
R10964 T16502 T16510 punct ",",were
R10965 T16437 T16437 ROOT phosphorylated,phosphorylated
R10966 T16503 T16504 det both,Ala
R10967 T16504 T16510 nsubj Ala,were
R10968 T16505 T16504 cc and,Ala
R10969 T16438 T16437 prep on,phosphorylated
R10970 T16506 T16504 conj Asp,Ala
R10971 T16507 T16504 conj mutants,Ala
R10972 T16508 T16507 prep of,mutants
R10973 T16439 T16438 pobj Thr308,on
R10974 T16509 T16508 pobj Thr308,of
R10975 T16510 T16510 ROOT were,were
R10976 T16440 T16437 prep after,phosphorylated
R10977 T16511 T16513 advmod significantly,active
R10978 T16512 T16513 advmod less,active
R10979 T16513 T16510 acomp active,were
R10980 T16441 T16442 det the,addition
R10981 T16514 T16513 prep in,active
R10982 T16442 T16440 pobj addition,after
R10983 T16515 T16514 pcomp promoting,in
R10984 T16516 T16517 compound cell,death
R10985 T16517 T16515 dobj death,promoting
R10986 T16518 T16514 punct ",",in
R10987 T16443 T16442 prep of,addition
R10988 T16519 T16513 conj phosphorylation,active
R10989 T16520 T16519 prep of,phosphorylation
R10990 T16521 T16520 pobj JNK,of
R10991 T16444 T16443 pobj zVAD,of
R10992 T16522 T16521 cc and,JNK
R10993 T16523 T16521 conj c-Jun,JNK
R10994 T16445 T16446 punct ",",displayed
R10995 T16524 T16523 punct ",",c-Jun
R10996 T16525 T16523 cc and,c-Jun
R10997 T16526 T16527 compound TNFα,mRNA
R10998 T16446 T16437 dep displayed,phosphorylated
R10999 T16527 T16523 conj mRNA,c-Jun
R11000 T16528 T16510 punct .,were
R11001 T16544 T16545 neg not,be
R11002 T16529 T16530 nsubj This,suggests
R11003 T16530 T16530 ROOT suggests,suggests
R11004 T16531 T16545 mark that,be
R11005 T16545 T16530 ccomp be,suggests
R11006 T16532 T16541 nsubj T308D,construct
R11007 T16533 T16532 punct ",",T308D
R11008 T16534 T16541 prep in,construct
R11009 T16535 T16534 pobj spite,in
R11010 T16536 T16535 prep of,spite
R11011 T16537 T16536 pcomp being,of
R11012 T16546 T16548 det a,mimic
R11013 T16538 T16540 det an,Akt
R11014 T16539 T16540 amod active,Akt
R11015 T16540 T16537 attr Akt,being
R11016 T16541 T16545 csubj construct,be
R11017 T16547 T16548 amod perfect,mimic
R11018 T16542 T16545 punct ",",be
R11019 T16543 T16545 aux may,be
R11020 T16548 T16545 attr mimic,be
R11021 T16549 T16548 prep of,mimic
R11022 T16550 T16549 pobj phosphorylation,of
R11023 T16641 T16638 ccomp phosphorylate,allowing
R11024 T16551 T16548 cc and,mimic
R11025 T16642 T16641 dobj substrates,phosphorylate
R11026 T16643 T16641 prep during,phosphorylate
R11027 T16644 T16643 pobj necroptosis,during
R11028 T16552 T16554 det this,form
R11029 T16645 T16641 punct ",",phosphorylate
R11030 T16646 T16641 dep promote,phosphorylate
R11031 T16553 T16554 amod mutant,form
R11032 T16647 T16648 compound TNFα,synthesis
R11033 T16648 T16646 dobj synthesis,promote
R11034 T16649 T16641 punct ",",phosphorylate
R11035 T16554 T16545 attr form,be
R11036 T16650 T16651 compound JNK,activation
R11037 T16651 T16641 conj activation,phosphorylate
R11038 T16555 T16554 prep of,form
R11039 T16652 T16651 cc and,activation
R11040 T16653 T16655 amod eventual,death
R11041 T16654 T16655 compound cell,death
R11042 T16556 T16557 det the,kinase
R11043 T16655 T16651 conj death,activation
R11044 T16656 T16622 punct .,is
R11045 T16557 T16555 pobj kinase,of
R11046 T16558 T16560 aux may,have
R11047 T16559 T16560 neg not,have
R11048 T16560 T16545 conj have,be
R11049 T16561 T16562 amod sufficient,activity
R11050 T16562 T16560 dobj activity,have
R11051 T16563 T16564 aux to,phosphorylate
R11052 T16564 T16562 relcl phosphorylate,activity
R11053 T16565 T16567 det the,repertoire
R11054 T16566 T16567 amod entire,repertoire
R11055 T16567 T16564 dobj repertoire,phosphorylate
R11056 T16568 T16567 prep of,repertoire
R11057 T16569 T16568 pobj substrates,of
R11058 T16570 T16569 prep in,substrates
R11059 T16571 T16572 det the,cells
R11060 T16572 T16570 pobj cells,in
R11061 T16573 T16530 punct .,suggests
R11062 T16574 T16575 advmod When,tested
R11063 T16575 T16580 advcl tested,support
R11064 T16576 T16580 punct ",",support
R11065 T16577 T16580 nsubj T308D,support
R11066 T16578 T16580 aux did,support
R11067 T16579 T16580 neg not,support
R11068 T16580 T16580 ROOT support,support
R11069 T16581 T16583 det the,phosphorylation
R11070 T16582 T16583 amod downstream,phosphorylation
R11071 T16583 T16580 dobj phosphorylation,support
R11072 T16584 T16583 prep of,phosphorylation
R11073 T16585 T16586 amod several,substrates
R11074 T16586 T16584 pobj substrates,of
R11075 T16587 T16589 nsubjpass that,phosphorylated
R11076 T16588 T16589 auxpass were,phosphorylated
R11077 T16589 T16586 relcl phosphorylated,substrates
R11078 T16590 T16589 agent by,phosphorylated
R11079 T16591 T16592 det the,Myr-Akt
R11080 T16592 T16590 pobj Myr-Akt,by
R11081 T16593 T16580 conj construct,support
R11082 T16594 T16593 prep in,construct
R11083 T16595 T16596 det the,presence
R11084 T16596 T16594 pobj presence,in
R11085 T16597 T16596 prep of,presence
R11086 T16598 T16597 pobj zVAD,of
R11087 T16599 T16596 prep including,presence
R11088 T16600 T16599 pobj FoxO1,including
R11089 T16601 T16600 punct ",",FoxO1
R11090 T16602 T16600 conj Foxo4,FoxO1
R11091 T16603 T16602 punct ",",Foxo4
R11092 T16604 T16602 conj MDM2,Foxo4
R11093 T16605 T16604 punct ",",MDM2
R11094 T16606 T16604 cc and,MDM2
R11095 T16607 T16604 conj p70S6K,MDM2
R11096 T16608 T16609 punct (,Fig
R11097 T16609 T16607 appos Fig,p70S6K
R11098 T16610 T16580 punct .,support
R11099 T16611 T16611 ROOT S8D,S8D
R11100 T16612 T16611 punct ),S8D
R11101 T16613 T16611 punct .,S8D
R11102 T16614 T16615 poss Our,model
R11103 T16615 T16622 nsubj model,is
R11104 T16616 T16615 punct ",",model
R11105 T16617 T16615 prep based,model
R11106 T16618 T16617 prep on,based
R11107 T16619 T16620 det these,results
R11108 T16620 T16618 pobj results,on
R11109 T16621 T16615 punct ",",model
R11110 T16622 T16622 ROOT is,is
R11111 T16623 T16627 mark that,provides
R11112 T16624 T16626 amod necroptosis-specific,phosphorylation
R11113 T16625 T16626 compound Thr308,phosphorylation
R11114 T16626 T16627 nsubj phosphorylation,provides
R11115 T16627 T16622 ccomp provides,is
R11116 T16628 T16630 det a,link
R11117 T16629 T16630 amod critical,link
R11118 T16630 T16627 dobj link,provides
R11119 T16631 T16630 prep between,link
R11120 T16632 T16633 amod necroptotic,machinery
R11121 T16633 T16631 pobj machinery,between
R11122 T16634 T16633 cc and,machinery
R11123 T16635 T16636 compound Akt,kinase
R11124 T16636 T16633 conj kinase,machinery
R11125 T16637 T16627 punct ",",provides
R11126 T16638 T16627 advcl allowing,provides
R11127 T16639 T16641 nsubj Akt,phosphorylate
R11128 T16640 T16641 aux to,phosphorylate
R21764 T31471 T31477 prep Over,restores
R21765 T31472 T31471 pobj expression,Over
R21766 T31473 T31472 prep of,expression
R21767 T31474 T31475 advmod constitutively,active
R21768 T31475 T31476 amod active,Akt
R21769 T31476 T31473 pobj Akt,of
R21770 T31477 T31477 ROOT restores,restores
R21771 T31478 T31477 dobj necroptosis,restores
R21772 T31479 T31477 prep under,restores
R21773 T31480 T31481 npadvmod serum,free
R21774 T31481 T31482 amod free,conditions
R21775 T31482 T31479 pobj conditions,under
R21776 T31483 T31477 punct .,restores
R21777 T31484 T31493 punct (,infected
R21778 T31485 T31493 intj A,infected
R21779 T31486 T31493 punct ",",infected
R21780 T31487 T31490 nmod B,cells
R21781 T31488 T31487 punct ),B
R21782 T31489 T31490 compound L929,cells
R21783 T31490 T31493 nsubjpass cells,infected
R21784 T31491 T31493 auxpass were,infected
R21785 T31492 T31493 advmod stably,infected
R21786 T31493 T31493 ROOT infected,infected
R21787 T31494 T31493 prep with,infected
R21788 T31495 T31497 amod empty,retrovirus
R21789 T31496 T31497 compound MSCV,retrovirus
R21790 T31497 T31494 pobj retrovirus,with
R21791 T31498 T31497 cc or,retrovirus
R21792 T31499 T31497 conj viruses,retrovirus
R21793 T31500 T31499 acl encoding,viruses
R21794 T31501 T31500 dobj Myr-Akt,encoding
R21795 T31502 T31501 cc or,Myr-Akt
R21796 T31503 T31507 det the,K179M
R21797 T31504 T31505 advmod catalytically,inactive
R21798 T31505 T31507 amod inactive,K179M
R21799 T31506 T31507 compound Myr-Akt,K179M
R21800 T31507 T31501 conj K179M,Myr-Akt
R21801 T31508 T31493 punct .,infected
R21802 T31509 T31511 nsubjpass Necroptosis,induced
R21803 T31510 T31511 auxpass was,induced
R21804 T31511 T31511 ROOT induced,induced
R21805 T31512 T31511 agent by,induced
R21806 T31513 T31514 det the,addition
R21807 T31514 T31512 pobj addition,by
R21808 T31515 T31514 prep of,addition
R21809 T31516 T31515 pobj zVAD.fmk,of
R21810 T31517 T31511 prep under,induced
R21811 T31518 T31519 npadvmod serum,free
R21812 T31519 T31520 amod free,conditions
R21813 T31520 T31517 pobj conditions,under
R21814 T31521 T31522 punct (,A
R21815 T31522 T31520 appos A,conditions
R21816 T31523 T31522 punct ),A
R21817 T31524 T31522 cc or,A
R21818 T31525 T31529 nmod serum,conditions
R21819 T31526 T31525 cc or,serum
R21820 T31527 T31525 conj serum,serum
R21821 T31528 T31529 amod free,conditions
R21822 T31529 T31520 appos conditions,conditions
R21823 T31530 T31529 prep with,conditions
R21824 T31531 T31530 pobj Nec-1,with
R21825 T31532 T31533 punct (,B
R21826 T31533 T31531 appos B,Nec-1
R21827 T31534 T31531 punct ),Nec-1
R21828 T31535 T31511 punct .,induced
R21829 T31536 T31537 compound Viability,assays
R21830 T31537 T31539 nsubjpass assays,performed
R21831 T31538 T31539 auxpass were,performed
R21832 T31539 T31539 ROOT performed,performed
R21833 T31540 T31539 prep after,performed
R21834 T31541 T31542 nummod 24,hr
R21835 T31542 T31540 pobj hr,after
R21836 T31543 T31539 punct .,performed
R21837 T31544 T31547 punct (,Myr-Akt
R21838 T31545 T31547 nmod C,Myr-Akt
R21839 T31546 T31547 punct ),Myr-Akt
R21840 T31547 T31551 nmod Myr-Akt,cells
R21841 T31548 T31547 cc and,Myr-Akt
R21842 T31549 T31550 compound Myr-Akt,K179M
R21843 T31550 T31547 conj K179M,Myr-Akt
R21844 T31551 T31553 nsubjpass cells,treated
R21845 T31552 T31553 auxpass were,treated
R21846 T31553 T31553 ROOT treated,treated
R21847 T31554 T31553 prep with,treated
R21848 T31555 T31554 pobj zVAD.fmk,with
R21849 T31556 T31555 cc and/or,zVAD.fmk
R21850 T31557 T31555 conj Nec-1,zVAD.fmk
R21851 T31558 T31553 prep under,treated
R21852 T31559 T31558 pobj serum,under
R21853 T31560 T31561 amod free,conditions
R21854 T31561 T31558 pobj conditions,under
R21855 T31562 T31553 prep for,treated
R21856 T31563 T31564 nummod 9,hr
R21857 T31564 T31562 pobj hr,for
R21858 T31565 T31553 punct ",",treated
R21859 T31566 T31553 advcl followed,treated
R21860 T31567 T31566 agent by,followed
R21861 T31568 T31569 amod western,blot
R21862 T31569 T31567 pobj blot,by
R21863 T31570 T31566 advcl using,followed
R21864 T31571 T31573 det the,antibodies
R21865 T31572 T31573 amod indicated,antibodies
R21866 T31573 T31570 dobj antibodies,using
R21867 T31574 T31553 punct .,treated
R21868 T31575 T31576 compound Endogenous,Akt
R21869 T31576 T31587 nsubjpass Akt,indicated
R21870 T31577 T31578 punct (,∼
R21871 T31578 T31576 parataxis ∼,Akt
R21872 T31579 T31578 punct ),∼
R21873 T31580 T31576 cc and,Akt
R21874 T31581 T31576 conj Myr-Akt,Akt
R21875 T31582 T31583 punct (,*
R21876 T31583 T31576 appos *,Akt
R21877 T31584 T31583 punct ),*
R21878 T31585 T31587 nsubjpass bands,indicated
R21879 T31586 T31587 auxpass are,indicated
R21880 T31587 T31587 ROOT indicated,indicated
R21881 T31588 T31587 punct .,indicated
R21882 T31589 T31604 punct (,stimulated
R21883 T31590 T31593 nmod D,cells
R21884 T31591 T31590 punct ),D
R21885 T31592 T31593 compound L929,cells
R21886 T31593 T31604 nsubjpass cells,stimulated
R21887 T31594 T31593 punct ",",cells
R21888 T31595 T31596 advmod stably,infected
R21889 T31596 T31593 acl infected,cells
R21890 T31597 T31596 prep with,infected
R21891 T31598 T31597 pobj Myr-Akt,with
R21892 T31599 T31598 cc and,Myr-Akt
R21893 T31600 T31601 compound Myr-Akt,K179KM
R21894 T31601 T31598 conj K179KM,Myr-Akt
R21895 T31602 T31604 punct ",",stimulated
R21896 T31603 T31604 auxpass were,stimulated
R21897 T31604 T31604 ROOT stimulated,stimulated
R21898 T31605 T31604 prep with,stimulated
R21899 T31606 T31605 pobj zVAD.fmk,with
R21900 T31607 T31604 prep for,stimulated
R21901 T31608 T31609 nummod 9,hr
R21902 T31609 T31607 pobj hr,for
R21903 T31610 T31609 prep under,hr
R21904 T31611 T31612 npadvmod serum,free
R21905 T31612 T31613 amod free,conditions
R21906 T31613 T31610 pobj conditions,under
R21907 T31614 T31604 punct .,stimulated
R21908 T31615 T31616 compound TNFα,mRNA
R21909 T31616 T31617 compound mRNA,levels
R21910 T31617 T31619 nsubjpass levels,determined
R21911 T31618 T31619 auxpass were,determined
R21912 T31619 T31619 ROOT determined,determined
R21913 T31620 T31619 agent by,determined
R21914 T31621 T31620 pobj qRT-PCR,by
R21915 T31622 T31619 cc and,determined
R21916 T31623 T31619 conj normalized,determined
R21917 T31624 T31623 advcl using,normalized
R21918 T31625 T31627 nmod mouse,RNA
R21919 T31626 T31627 nummod 18S,RNA
R21920 T31627 T31624 dobj RNA,using
R21921 T31628 T31619 punct .,determined
R21922 T31629 T31646 punct (,treated
R21923 T31630 T31633 compound E-G,cells
R21924 T31631 T31632 punct ),L929
R21925 T31632 T31633 compound L929,cells
R21926 T31633 T31646 nsubjpass cells,treated
R21927 T31634 T31633 acl expressing,cells
R21928 T31635 T31634 dobj Myr-Akt,expressing
R21929 T31636 T31635 cc and,Myr-Akt
R21930 T31637 T31635 conj Ala,Myr-Akt
R21931 T31638 T31637 cc and,Ala
R21932 T31639 T31637 conj Asp,Ala
R21933 T31640 T31635 conj mutants,Myr-Akt
R21934 T31641 T31640 prep of,mutants
R21935 T31642 T31641 pobj Thr308,of
R21936 T31643 T31642 cc and,Thr308
R21937 T31644 T31642 conj Ser473,Thr308
R21938 T31645 T31646 auxpass were,treated
R21939 T31646 T31646 ROOT treated,treated
R21940 T31647 T31646 prep with,treated
R21941 T31648 T31647 pobj zVAD.fmk,with
R21942 T31649 T31646 prep under,treated
R21943 T31650 T31651 npadvmod serum,free
R21944 T31651 T31652 amod free,conditions
R21945 T31652 T31649 pobj conditions,under
R21946 T31653 T31646 punct ",",treated
R21947 T31654 T31646 advcl followed,treated
R21948 T31655 T31654 agent by,followed
R21949 T31656 T31657 compound viability,assay
R21950 T31657 T31655 pobj assay,by
R21951 T31658 T31654 prep at,followed
R21952 T31659 T31660 nummod 24,hr
R21953 T31660 T31658 pobj hr,at
R21954 T31661 T31662 punct (,E
R21955 T31662 T31660 appos E,hr
R21956 T31663 T31662 punct ),E
R21957 T31664 T31660 punct ",",hr
R21958 T31665 T31666 amod western,blot
R21959 T31666 T31654 npadvmod blot,followed
R21960 T31667 T31654 prep at,followed
R21961 T31668 T31669 nummod 9,hr
R21962 T31669 T31667 pobj hr,at
R21963 T31670 T31671 punct (,F
R21964 T31671 T31669 appos F,hr
R21965 T31672 T31669 punct ),hr
R21966 T31673 T31669 punct ",",hr
R21967 T31674 T31669 cc or,hr
R21968 T31675 T31669 conj evaluation,hr
R21969 T31676 T31669 prep of,hr
R21970 T31677 T31678 compound TNFα,mRNA
R21971 T31678 T31679 compound mRNA,levels
R21972 T31679 T31676 pobj levels,of
R21973 T31680 T31654 agent by,followed
R21974 T31681 T31680 pobj qRT-PCR,by
R21975 T31682 T31654 prep at,followed
R21976 T31683 T31684 nummod 9,hrs
R21977 T31684 T31682 pobj hrs,at
R21978 T31685 T31686 punct (,G
R21979 T31686 T31684 appos G,hrs
R21980 T31687 T31684 punct ),hrs
R21981 T31688 T31646 punct .,treated
R21982 T31689 T31697 prep In,plotted
R21983 T31690 T31691 det all,graphs
R21984 T31691 T31689 pobj graphs,In
R21985 T31692 T31697 punct ",",plotted
R21986 T31693 T31694 amod average,±
R21987 T31694 T31695 compound ±,SD
R21988 T31695 T31697 nsubjpass SD,plotted
R21989 T31696 T31697 auxpass was,plotted
R21990 T31697 T31697 ROOT plotted,plotted
R21991 T31698 T31697 punct .,plotted

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T15449 6294-6304 Positive_regulation denotes activation
T15448 6294-6304 Positive_regulation denotes activation
T15447 6279-6288 Gene_expression denotes synthesis
T15446 6290-6293 Protein denotes JNK
T15445 6274-6278 Protein denotes TNFα
T15444 6214-6217 Protein denotes Akt
T15443 6193-6203 Protein denotes Akt kinase
T15442 5930-5944 Phosphorylation denotes phosphorylated
T15441 5930-5944 Phosphorylation denotes phosphorylated
T15440 5930-5944 Phosphorylation denotes phosphorylated
T15439 5930-5944 Phosphorylation denotes phosphorylated
T15438 6041-6044 Protein denotes S8D
T15437 6036-6039 Protein denotes Fig
T15436 6028-6034 Protein denotes p70S6K
T15435 6018-6022 Protein denotes MDM2
T15434 6011-6016 Protein denotes Foxo4
T15433 5989-6009 Protein denotes zVAD including FoxO1
T15432 5956-5959 Protein denotes Akt
T15431 5952-5955 Protein denotes Myr
T15430 5681-5696 Phosphorylation denotes phosphorylation
T15429 5636-5639 Protein denotes Akt
T15428 5511-5520 Positive_regulation denotes promoting
T15427 5511-5520 Positive_regulation denotes promoting
T15426 5533-5548 Phosphorylation denotes phosphorylation
T15425 5533-5548 Phosphorylation denotes phosphorylation
T15424 5511-5520 Positive_regulation denotes promoting
T15423 5571-5580 Protein denotes TNFα mRNA
T15422 5560-5565 Protein denotes c-Jun
T15421 5552-5555 Protein denotes JNK
T15420 5349-5363 Phosphorylation denotes phosphorylated
T15419 5260-5274 Phosphorylation denotes phosphorylated
T15418 5395-5399 Protein denotes PDK1
T15417 5278-5284 Protein denotes Thr308
T15416 4910-4924 Protein denotes Ser473 mutants
T15415 4899-4905 Protein denotes Thr308
T15414 4827-4836 Negative_regulation denotes decreases
T15413 4794-4805 Protein denotes Ala mutants
T15412 4723-4734 Protein denotes Asp mutants
T15411 4640-4646 Regulation denotes effect
T15410 4658-4669 Protein denotes Asp mutants
T15409 4538-4547 Negative_regulation denotes reduction
T15408 4588-4599 Protein denotes Asp mutants
T15407 4577-4580 Protein denotes Akt
T15406 4382-4386 Regulation denotes role
T15405 4421-4431 Regulation denotes regulation
T15404 4398-4413 Phosphorylation denotes phosphorylation
T15403 4464-4467 Protein denotes Akt
T15402 4391-4397 Protein denotes Thr308
T15401 4238-4247 Positive_regulation denotes increased
T15400 4255-4270 Phosphorylation denotes phosphorylation
T15399 4147-4154 Negative_regulation denotes lacking
T15398 4147-4154 Negative_regulation denotes lacking
T15397 4248-4254 Protein denotes Thr308
T15396 4182-4189 Protein denotes Myr tag
T15395 4164-4173 Protein denotes PH domain
T15394 4119-4134 Protein denotes Full length Akt
T15393 4086-4098 Localization denotes localization
T15392 4102-4105 Protein denotes Akt
T15391 3903-3913 Positive_regulation denotes activation
T15390 3959-3968 Gene_expression denotes expressed
T15378 3689-3698 Positive_regulation denotes increased
T15377 3637-3652 Phosphorylation denotes phosphorylation
T15376 3637-3652 Phosphorylation denotes phosphorylation
T15375 3786-3789 Protein denotes Akt
T15374 3782-3785 Protein denotes Myr
T15373 3666-3670 Protein denotes MDM2
T15372 3656-3661 Protein denotes FoxO1
T15371 3570-3584 Phosphorylation denotes phosphorylated
T15370 3570-3584 Phosphorylation denotes phosphorylated
T15369 3570-3584 Phosphorylation denotes phosphorylated
T15368 3570-3584 Phosphorylation denotes phosphorylated
T15367 3552-3557 Protein denotes FoxO4
T15366 3542-3547 Protein denotes GSK-3
T15365 3538-3540 Protein denotes S6
T15364 3530-3536 Protein denotes p70S6K
T15363 3466-3475 Positive_regulation denotes increased
T15362 3494-3501 Protein denotes Myr-Akt
T15361 3267-3277 Gene_expression denotes expression
T15360 3267-3277 Gene_expression denotes expression
T15359 3248-3257 Positive_regulation denotes increased
T15358 3184-3199 Phosphorylation denotes Phosphorylation
T15357 3352-3355 Protein denotes Akt
T15356 3285-3288 Protein denotes Akt
T15355 3281-3284 Protein denotes Myr
T15347 3131-3134 Protein denotes Akt
T15346 3127-3130 Protein denotes Myr
T15345 3090-3097 Protein denotes Myr-Akt
T15343 1676-1684 Regulation denotes regulate
T15342 1689-1699 Positive_regulation denotes activation
T15341 1755-1766 Protein denotes RIP1 kinase
T15340 1685-1688 Protein denotes Akt
T15339 1646-1657 Protein denotes RIP1 kinase
T15338 1573-1581 Positive_regulation denotes uncouple
T15337 1586-1596 Positive_regulation denotes activation
T15336 1582-1585 Protein denotes Akt
T15313 693-696 Protein denotes Akt
T15312 689-692 Protein denotes Myr
T15311 487-499 Localization denotes localization
T15310 351-357 Positive_regulation denotes active
T15309 351-357 Positive_regulation denotes active
T15308 368-371 Protein denotes Akt
T15307 364-367 Protein denotes Myr
T15306 358-362 Protein denotes Akt1
T15305 251-263 Positive_regulation denotes contribution
T15304 305-315 Positive_regulation denotes activation
T15303 141-147 Positive_regulation denotes active
T15302 141-147 Positive_regulation denotes active
T15301 115-125 Gene_expression denotes expressing
T15300 115-125 Gene_expression denotes expressing
T15299 115-125 Gene_expression denotes expressing
T15298 301-304 Protein denotes Akt
T15297 286-297 Protein denotes RIP1 kinase
T15296 168-171 Protein denotes Akt
T15295 164-167 Protein denotes Myr
T15294 148-162 Protein denotes wild type Akt1
T15354 3229-3232 Protein denotes Akt
T15352 3117-3126 Positive_regulation denotes increased
T15351 3117-3126 Positive_regulation denotes increased
T15349 3175-3178 Protein denotes Fig
T15348 3170-3173 Protein denotes Akt
T15335 1552-1555 Protein denotes Akt
T15334 1270-1280 Positive_regulation denotes activation
T15333 1328-1340 Positive_regulation denotes upregulation
T15332 1298-1313 Phosphorylation denotes phosphorylation
T15331 1270-1280 Positive_regulation denotes activation
T15330 1435-1438 Protein denotes Akt
T15329 1355-1358 Protein denotes Fig
T15328 1344-1353 Protein denotes TNFα mRNA
T15327 1292-1297 Protein denotes c-Jun
T15326 1284-1287 Protein denotes JNK
T15325 1210-1213 Protein denotes Akt
T15324 1206-1209 Protein denotes Myr
T15323 1073-1082 Negative_regulation denotes prevented
T15322 1154-1162 Positive_regulation denotes increase
T15321 1177-1192 Phosphorylation denotes phosphorylation
T15320 1166-1169 Protein denotes Akt
T15319 1092-1095 Protein denotes Akt
T15318 1088-1091 Protein denotes Myr
T15317 1067-1072 Protein denotes Nec-1
T15316 885-888 Protein denotes Akt
T15315 678-688 Gene_expression denotes expressing
T15314 678-688 Gene_expression denotes expressing
T15389 3959-3968 Gene_expression denotes expressed
T15388 3920-3930 Gene_expression denotes production
T15387 3903-3913 Positive_regulation denotes activation
T15386 3973-3976 Protein denotes Akt
T15385 3969-3972 Protein denotes Myr
T15384 3915-3919 Protein denotes TNFα
T15383 3899-3902 Protein denotes JNK
T15382 3763-3778 Phosphorylation denotes phosphorylation
T15381 3763-3778 Phosphorylation denotes phosphorylation
T15380 3744-3755 Entity denotes necroptotic
T15379 3689-3698 Positive_regulation denotes increased
T31721 2756-2766 Gene_expression denotes expressing
T31720 2961-2970 Protein denotes TNFα mRNA
T31719 2767-2774 Protein denotes Myr-Akt
T31718 2724-2737 Protein denotes mouse 18S RNA
T31717 2659-2668 Protein denotes TNFα mRNA
T31716 2612-2620 Protein denotes zVAD.fmk
T31715 2575-2589 Protein denotes Myr-Akt K179KM
T31714 2563-2570 Protein denotes Myr-Akt
T31713 2497-2500 Protein denotes Akt
T31712 2493-2496 Protein denotes Myr
T31711 2353-2361 Protein denotes zVAD.fmk
T31710 2319-2322 Protein denotes Akt
T31709 2315-2318 Protein denotes Myr
T31708 2307-2310 Protein denotes Akt
T31707 2303-2306 Protein denotes Myr
T31706 2105-2118 Protein denotes Myr-Akt K179M
T31705 2067-2074 Protein denotes Myr-Akt
R10042 T15294 T15299 themeOf wild type Akt1,expressing
R10043 T15294 T15302 themeOf wild type Akt1,active
R10044 T15295 T15300 themeOf Myr,expressing
R10045 T15296 T15301 themeOf Akt,expressing
R10046 T15296 T15303 themeOf Akt,active
R10047 T15298 T15304 themeOf Akt,activation
R10048 T15304 T15305 themeOf activation,contribution
R10049 T15306 T15309 themeOf Akt1,active
R10050 T15308 T15310 themeOf Akt,active
R10051 T15308 T15311 themeOf Akt,localization
R10052 T15312 T15314 themeOf Myr,expressing
R10053 T15313 T15315 themeOf Akt,expressing
R10054 T15317 T15323 causeOf Nec-1,prevented
R10055 T15320 T15321 themeOf Akt,phosphorylation
R10056 T15321 T15322 themeOf phosphorylation,increase
R10057 T15322 T15323 themeOf increase,prevented
R10058 T15326 T15331 themeOf JNK,activation
R10059 T15327 T15332 themeOf c-Jun,phosphorylation
R10060 T15328 T15333 themeOf TNFα mRNA,upregulation
R10061 T15329 T15333 causeOf Fig,upregulation
R10062 T15332 T15334 themeOf phosphorylation,activation
R10063 T15336 T15337 themeOf Akt,activation
R10064 T15337 T15338 themeOf activation,uncouple
R10065 T15339 T15343 causeOf RIP1 kinase,regulate
R10066 T15340 T15342 themeOf Akt,activation
R10067 T15342 T15343 themeOf activation,regulate
R10070 T15347 T15351 themeOf Akt,increased
R10071 T15347 T15352 themeOf Akt,increased
R10072 T15349 T15351 causeOf Fig,increased
R10075 T15354 T15358 themeOf Akt,Phosphorylation
R10076 T15355 T15360 themeOf Myr,expression
R10077 T15356 T15361 themeOf Akt,expression
R10078 T15358 T15359 themeOf Phosphorylation,increased
R10079 T15362 T15363 themeOf Myr-Akt,increased
R10080 T15364 T15368 themeOf p70S6K,phosphorylated
R10081 T15365 T15369 themeOf S6,phosphorylated
R10082 T15366 T15370 themeOf GSK-3,phosphorylated
R10083 T15367 T15371 themeOf FoxO4,phosphorylated
R10084 T15372 T15376 themeOf FoxO1,phosphorylation
R10085 T15373 T15377 themeOf MDM2,phosphorylation
R10086 T15374 T15381 themeOf Myr,phosphorylation
R10087 T15374 T15380 partOf Myr,necroptotic
R10088 T15375 T15382 themeOf Akt,phosphorylation
R10089 T15375 T15380 partOf Akt,necroptotic
R10090 T15376 T15378 themeOf phosphorylation,increased
R10091 T15377 T15379 themeOf phosphorylation,increased
R10092 T15380 T15381 Site necroptotic,phosphorylation
R10093 T15380 T15382 Site necroptotic,phosphorylation
R10094 T15383 T15387 themeOf JNK,activation
R10095 T15384 T15388 themeOf TNFα,production
R10096 T15385 T15389 themeOf Myr,expressed
R10097 T15386 T15390 themeOf Akt,expressed
R10098 T15388 T15391 themeOf production,activation
R10099 T15392 T15393 themeOf Akt,localization
R10100 T15394 T15401 causeOf Full length Akt,increased
R10101 T15395 T15398 themeOf PH domain,lacking
R10102 T15396 T15399 themeOf Myr tag,lacking
R10103 T15397 T15400 themeOf Thr308,phosphorylation
R10104 T15400 T15401 themeOf phosphorylation,increased
R10105 T15402 T15404 themeOf Thr308,phosphorylation
R10106 T15403 T15405 themeOf Akt,regulation
R10107 T15405 T15406 themeOf regulation,role
R10108 T15407 T15409 themeOf Akt,reduction
R10109 T15410 T15411 themeOf Asp mutants,effect
R10110 T15413 T15414 themeOf Ala mutants,decreases
R10111 T15417 T15419 themeOf Thr308,phosphorylated
R10112 T15417 T15420 themeOf Thr308,phosphorylated
R10113 T15421 T15425 themeOf JNK,phosphorylation
R10114 T15422 T15426 themeOf c-Jun,phosphorylation
R10115 T15423 T15424 themeOf TNFα mRNA,promoting
R10116 T15425 T15427 themeOf phosphorylation,promoting
R10117 T15426 T15428 themeOf phosphorylation,promoting
R10118 T15429 T15430 themeOf Akt,phosphorylation
R10119 T15432 T15439 themeOf Akt,phosphorylated
R10120 T15433 T15440 themeOf zVAD including FoxO1,phosphorylated
R10121 T15434 T15441 themeOf Foxo4,phosphorylated
R10122 T15435 T15442 themeOf MDM2,phosphorylated
R10123 T15445 T15447 themeOf TNFα,synthesis
R10124 T15446 T15448 themeOf JNK,activation
R10125 T15447 T15449 themeOf synthesis,activation
R21992 T31719 T31721 themeOf Myr-Akt,expressing

test3

Id Subject Object Predicate Lexical cue
T31176 2961-2965 Protein denotes TNFα
T31175 2756-2766 Gene_expression denotes expressing
T31174 2730-2733 Protein denotes 18S
T31173 2659-2663 Protein denotes TNFα
T31172 2136-2143 Positive_regulation denotes induced
T31171 2961-2965 Protein denotes TNFα
T31170 2730-2733 Protein denotes 18S
T31169 2659-2663 Protein denotes TNFα
T13688 6279-6288 Gene_expression denotes synthesis
T13687 6274-6278 Protein denotes TNFα
T13686 6266-6273 Positive_regulation denotes promote
T13685 6221-6234 Phosphorylation denotes phosphorylate
T13684 6205-6213 Positive_regulation denotes allowing
T13683 6028-6034 Protein denotes p70S6K
T13682 6018-6022 Protein denotes MDM2
T13681 6011-6016 Protein denotes Foxo4
T13680 6004-6009 Protein denotes FoxO1
T13679 5952-5959 Protein denotes Myr-Akt
T13678 5930-5944 Phosphorylation denotes phosphorylated
T13677 5845-5850 Protein denotes T308D
T13676 5629-5635 Positive_regulation denotes active
T13675 5601-5606 Protein denotes T308D
T13674 5571-5575 Protein denotes TNFα
T13673 5560-5565 Protein denotes c-Jun
T13672 5533-5548 Phosphorylation denotes phosphorylation
T13671 5403-5416 Phosphorylation denotes phosphorylate
T13670 5395-5399 Protein denotes PDK1
T13669 5349-5363 Phosphorylation denotes phosphorylated
T13668 5338-5342 Entity denotes site
T13667 5260-5274 Phosphorylation denotes phosphorylated
T13666 5225-5230 Protein denotes S473A
T13665 5158-5163 Protein denotes S473A
T13664 5134-5141 Negative_regulation denotes reduced
T13663 5057-5071 Phosphorylation denotes phosphorylated
T13662 5033-5045 Protein denotes S473D mutant
T13661 4577-4580 Protein denotes Akt
T13660 4538-4547 Negative_regulation denotes reduction
T13659 4421-4431 Regulation denotes regulation
T13658 4398-4413 Phosphorylation denotes phosphorylation
T13657 4382-4386 Regulation denotes role
T13656 4255-4270 Phosphorylation denotes phosphorylation
T13655 4238-4247 Positive_regulation denotes increased
T13654 4147-4154 Negative_regulation denotes lacking
T13653 4109-4117 Positive_regulation denotes required
T13652 4086-4098 Localization denotes localization
T13651 3969-3976 Protein denotes Myr-Akt
T13650 3959-3968 Gene_expression denotes expressed
T13649 3937-3946 Regulation denotes dependent
T13648 3920-3930 Gene_expression denotes production
T13647 3915-3919 Protein denotes TNFα
T13646 3782-3789 Protein denotes Myr-Akt
T13645 3763-3778 Phosphorylation denotes phosphorylation
T13644 3689-3698 Positive_regulation denotes increased
T13643 3666-3670 Protein denotes MDM2
T13642 3656-3661 Protein denotes FoxO1
T13641 3637-3652 Phosphorylation denotes phosphorylation
T13640 3597-3604 Negative_regulation denotes absence
T13639 3570-3584 Phosphorylation denotes phosphorylated
T13638 3552-3557 Protein denotes FoxO4
T13637 3538-3540 Protein denotes S6
T13636 3530-3536 Protein denotes p70S6K
T13635 3494-3501 Protein denotes Myr-Akt
T13634 3466-3475 Positive_regulation denotes increased
T13633 3302-3307 Protein denotes K179M
T13632 3281-3288 Protein denotes Myr-Akt
T13631 3267-3277 Gene_expression denotes expression
T13630 3248-3257 Positive_regulation denotes increased
T13629 3127-3134 Protein denotes Myr-Akt
T13628 3117-3126 Positive_regulation denotes increased
T13627 3090-3097 Protein denotes Myr-Akt
T13623 1798-1806 Positive_regulation denotes required
T13622 1755-1759 Protein denotes RIP1
T13621 1689-1699 Positive_regulation denotes activation
T13620 1676-1684 Regulation denotes regulate
T13619 1646-1650 Protein denotes RIP1
T13618 1586-1596 Positive_regulation denotes activation
T13617 1426-1430 Regulation denotes role
T13616 1344-1348 Protein denotes TNFα
T13615 1328-1340 Positive_regulation denotes upregulation
T13614 1298-1313 Phosphorylation denotes phosphorylation
T13613 1292-1297 Protein denotes c-Jun
T13612 1177-1192 Phosphorylation denotes phosphorylation
T13611 1154-1162 Positive_regulation denotes increase
T13610 1088-1095 Protein denotes Myr-Akt
T13609 996-1001 Protein denotes K179M
T13608 975-982 Protein denotes Myr-Akt
T13607 689-696 Protein denotes Myr-Akt
T13606 678-688 Gene_expression denotes expressing
T13605 586-595 Positive_regulation denotes resulting
T13604 364-371 Protein denotes Myr-Akt
T13603 358-362 Protein denotes Akt1
T13602 305-315 Positive_regulation denotes activation
T13601 286-290 Protein denotes RIP1
T13600 210-215 Protein denotes K179M
T13599 164-171 Protein denotes Myr-Akt
T13598 158-162 Protein denotes Akt1
T13597 115-125 Gene_expression denotes expressing
T13596 29-35 Positive_regulation denotes Active
T13595 0-10 Gene_expression denotes Expression
T13594 6274-6278 Protein denotes TNFα
T13593 6028-6034 Protein denotes p70S6K
T13592 6018-6022 Protein denotes MDM2
T13591 6011-6016 Protein denotes Foxo4
T13590 6004-6009 Protein denotes FoxO1
T13589 5952-5959 Protein denotes Myr-Akt
T13588 5845-5850 Protein denotes T308D
T13587 5601-5606 Protein denotes T308D
T13586 5571-5575 Protein denotes TNFα
T13585 5560-5565 Protein denotes c-Jun
T13584 5395-5399 Protein denotes PDK1
T13583 5225-5230 Protein denotes S473A
T13582 5158-5163 Protein denotes S473A
T13581 5033-5045 Protein denotes S473D mutant
T13580 4577-4580 Protein denotes Akt
T13579 3969-3976 Protein denotes Myr-Akt
T13578 3915-3919 Protein denotes TNFα
T13577 3782-3789 Protein denotes Myr-Akt
T13576 3666-3670 Protein denotes MDM2
T13575 3656-3661 Protein denotes FoxO1
T13574 3552-3557 Protein denotes FoxO4
T13573 3538-3540 Protein denotes S6
T13572 3530-3536 Protein denotes p70S6K
T13571 3494-3501 Protein denotes Myr-Akt
T13570 3302-3307 Protein denotes K179M
T13569 3281-3288 Protein denotes Myr-Akt
T13568 3127-3134 Protein denotes Myr-Akt
T13567 3090-3097 Protein denotes Myr-Akt
T13565 1755-1759 Protein denotes RIP1
T13564 1646-1650 Protein denotes RIP1
T13563 1344-1348 Protein denotes TNFα
T13562 1292-1297 Protein denotes c-Jun
T13561 1088-1095 Protein denotes Myr-Akt
T13560 996-1001 Protein denotes K179M
T13559 975-982 Protein denotes Myr-Akt
T13558 689-696 Protein denotes Myr-Akt
T13557 364-371 Protein denotes Myr-Akt
T13556 358-362 Protein denotes Akt1
T13555 286-290 Protein denotes RIP1
T13554 210-215 Protein denotes K179M
T13553 164-171 Protein denotes Myr-Akt
T13552 158-162 Protein denotes Akt1
R8933 T13616 T13615 themeOf TNFα,upregulation
R8934 T13621 T13620 themeOf activation,regulate
R8938 T13629 T13628 themeOf Myr-Akt,increased
R8939 T13632 T13631 themeOf Myr-Akt,expression
R8940 T13633 T13631 themeOf K179M,expression
R8941 T13636 T13639 themeOf p70S6K,phosphorylated
R8942 T13637 T13639 themeOf S6,phosphorylated
R8943 T13638 T13639 themeOf FoxO4,phosphorylated
R8944 T13641 T13644 themeOf phosphorylation,increased
R8945 T13642 T13641 themeOf FoxO1,phosphorylation
R8946 T13643 T13641 themeOf MDM2,phosphorylation
R8947 T13646 T13645 themeOf Myr-Akt,phosphorylation
R8948 T13647 T13648 themeOf TNFα,production
R8949 T13648 T13649 themeOf production,dependent
R8950 T13650 T13649 themeOf expressed,dependent
R8951 T13651 T13650 themeOf Myr-Akt,expressed
R8952 T13652 T13653 themeOf localization,required
R8953 T13656 T13655 themeOf phosphorylation,increased
R8954 T13658 T13657 themeOf phosphorylation,role
R8955 T13662 T13663 themeOf S473D mutant,phosphorylated
R8956 T13663 T13664 themeOf phosphorylated,reduced
R8957 T13666 T13667 themeOf S473A,phosphorylated
R8958 T13673 T13672 themeOf c-Jun,phosphorylation
R8959 T13674 T13672 themeOf TNFα,phosphorylation
R8960 T13677 T13678 themeOf T308D,phosphorylated
R8961 T13679 T13678 themeOf Myr-Akt,phosphorylated
R8962 T13685 T13684 themeOf phosphorylate,allowing
R8963 T13685 T13686 causeOf phosphorylate,promote
R8964 T13687 T13688 themeOf TNFα,synthesis
R8965 T13688 T13686 themeOf synthesis,promote
R8927 T13598 T13597 themeOf Akt1,expressing
R8928 T13599 T13598 equivalentTo Myr-Akt,Akt1
R8929 T13604 T13603 equivalentTo Myr-Akt,Akt1
R8930 T13607 T13606 themeOf Myr-Akt,expressing
R8931 T13612 T13611 themeOf phosphorylation,increase
R8932 T13613 T13614 themeOf c-Jun,phosphorylation