PMC:3585731 / 21889-22645
Annnotations
testone
{"project":"testone","denotations":[{"id":"T8937","span":{"begin":560,"end":569},"obj":"Negative_regulation"},{"id":"T8936","span":{"begin":527,"end":536},"obj":"Negative_regulation"},{"id":"T8935","span":{"begin":488,"end":497},"obj":"Negative_regulation"},{"id":"T8934","span":{"begin":320,"end":329},"obj":"Negative_regulation"},{"id":"T8933","span":{"begin":282,"end":292},"obj":"Negative_regulation"},{"id":"T8899","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T8898","span":{"begin":352,"end":358},"obj":"Protein"}],"relations":[{"id":"R5803","pred":"themeOf","subj":"T8898","obj":"T8934"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
2_test
{"project":"2_test","denotations":[{"id":"23469174-18955974-90505435","span":{"begin":156,"end":158},"obj":"18955974"},{"id":"23469174-12150925-90505436","span":{"begin":360,"end":362},"obj":"12150925"},{"id":"23469174-20860370-90505437","span":{"begin":461,"end":463},"obj":"20860370"},{"id":"23469174-16697955-90505438","span":{"begin":506,"end":508},"obj":"16697955"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
pmc-enju-pas
{"project":"pmc-enju-pas","denotations":[{"id":"T9757","span":{"begin":754,"end":755},"obj":"-RRB-"},{"id":"T9756","span":{"begin":752,"end":754},"obj":"NN"},{"id":"T9755","span":{"begin":747,"end":751},"obj":"NN"},{"id":"T9754","span":{"begin":746,"end":747},"obj":"-LRB-"},{"id":"T9753","span":{"begin":740,"end":745},"obj":"NN"},{"id":"T9752","span":{"begin":732,"end":739},"obj":"VB"},{"id":"T9751","span":{"begin":727,"end":731},"obj":"NN"},{"id":"T9750","span":{"begin":723,"end":726},"obj":"CC"},{"id":"T9749","span":{"begin":714,"end":722},"obj":"NN"},{"id":"T9748","span":{"begin":709,"end":713},"obj":"CC"},{"id":"T9747","span":{"begin":704,"end":708},"obj":"IN"},{"id":"T9746","span":{"begin":698,"end":703},"obj":"NN"},{"id":"T9745","span":{"begin":687,"end":697},"obj":"VB"},{"id":"T9744","span":{"begin":684,"end":686},"obj":"IN"},{"id":"T9743","span":{"begin":672,"end":683},"obj":"NN"},{"id":"T9742","span":{"begin":669,"end":671},"obj":"IN"},{"id":"T9741","span":{"begin":664,"end":668},"obj":"NN"},{"id":"T9740","span":{"begin":660,"end":663},"obj":"IN"},{"id":"T9739","span":{"begin":655,"end":659},"obj":"NN"},{"id":"T9738","span":{"begin":653,"end":654},"obj":"DT"},{"id":"T9737","span":{"begin":642,"end":652},"obj":"VB"},{"id":"T9736","span":{"begin":637,"end":641},"obj":"NN"},{"id":"T9735","span":{"begin":627,"end":636},"obj":"NN"},{"id":"T9734","span":{"begin":612,"end":626},"obj":"JJ"},{"id":"T9733","span":{"begin":608,"end":611},"obj":"DT"},{"id":"T9732","span":{"begin":598,"end":607},"obj":"VB"},{"id":"T9731","span":{"begin":590,"end":597},"obj":"RB"},{"id":"T9730","span":{"begin":584,"end":589},"obj":"NN"},{"id":"T9729","span":{"begin":578,"end":583},"obj":"VB"},{"id":"T9728","span":{"begin":573,"end":577},"obj":"NN"},{"id":"T9727","span":{"begin":570,"end":572},"obj":"IN"},{"id":"T9726","span":{"begin":560,"end":569},"obj":"NN"},{"id":"T9725","span":{"begin":557,"end":558},"obj":"-RRB-"},{"id":"T9724","span":{"begin":555,"end":557},"obj":"NN"},{"id":"T9723","span":{"begin":550,"end":554},"obj":"NN"},{"id":"T9722","span":{"begin":549,"end":550},"obj":"-LRB-"},{"id":"T9721","span":{"begin":537,"end":548},"obj":"NN"},{"id":"T9720","span":{"begin":527,"end":536},"obj":"VB"},{"id":"T9719","span":{"begin":515,"end":526},"obj":"RB"},{"id":"T9718","span":{"begin":510,"end":514},"obj":"RB"},{"id":"T9717","span":{"begin":508,"end":509},"obj":"-RRB-"},{"id":"T9716","span":{"begin":506,"end":508},"obj":"CD"},{"id":"T9715","span":{"begin":505,"end":506},"obj":"-LRB-"},{"id":"T9714","span":{"begin":498,"end":504},"obj":"NN"},{"id":"T9713","span":{"begin":488,"end":497},"obj":"NN"},{"id":"T9712","span":{"begin":478,"end":487},"obj":"NN"},{"id":"T9711","span":{"begin":473,"end":477},"obj":"JJ"},{"id":"T9710","span":{"begin":469,"end":472},"obj":"DT"},{"id":"T9709","span":{"begin":465,"end":468},"obj":"CC"},{"id":"T9708","span":{"begin":463,"end":464},"obj":"-RRB-"},{"id":"T9707","span":{"begin":461,"end":463},"obj":"CD"},{"id":"T9706","span":{"begin":460,"end":461},"obj":"-LRB-"},{"id":"T9705","span":{"begin":453,"end":459},"obj":"NN"},{"id":"T9704","span":{"begin":443,"end":452},"obj":"NN"},{"id":"T9703","span":{"begin":436,"end":442},"obj":"NN"},{"id":"T9702","span":{"begin":431,"end":435},"obj":"NN"},{"id":"T9701","span":{"begin":424,"end":430},"obj":"JJ"},{"id":"T9700","span":{"begin":420,"end":423},"obj":"DT"},{"id":"T9699","span":{"begin":418,"end":419},"obj":"-COMMA-"},{"id":"T9698","span":{"begin":409,"end":418},"obj":"RB"},{"id":"T9697","span":{"begin":406,"end":407},"obj":"-RRB-"},{"id":"T9696","span":{"begin":404,"end":406},"obj":"NN"},{"id":"T9695","span":{"begin":399,"end":403},"obj":"NN"},{"id":"T9694","span":{"begin":398,"end":399},"obj":"-LRB-"},{"id":"T9693","span":{"begin":386,"end":397},"obj":"NN"},{"id":"T9692","span":{"begin":381,"end":385},"obj":"IN"},{"id":"T9691","span":{"begin":375,"end":380},"obj":"NN"},{"id":"T9690","span":{"begin":365,"end":374},"obj":"JJ"},{"id":"T9689","span":{"begin":363,"end":364},"obj":"-COMMA-"},{"id":"T9688","span":{"begin":362,"end":363},"obj":"-RRB-"},{"id":"T9687","span":{"begin":360,"end":362},"obj":"CD"},{"id":"T9686","span":{"begin":359,"end":360},"obj":"-LRB-"},{"id":"T9685","span":{"begin":352,"end":358},"obj":"NN"},{"id":"T9684","span":{"begin":342,"end":351},"obj":"NN"},{"id":"T9683","span":{"begin":337,"end":341},"obj":"NN"},{"id":"T9682","span":{"begin":333,"end":336},"obj":"DT"},{"id":"T9681","span":{"begin":330,"end":332},"obj":"IN"},{"id":"T9680","span":{"begin":320,"end":329},"obj":"NN"},{"id":"T9679","span":{"begin":317,"end":319},"obj":"DT"},{"id":"T9678","span":{"begin":315,"end":316},"obj":"-COMMA-"},{"id":"T9677","span":{"begin":306,"end":315},"obj":"NN"},{"id":"T9676","span":{"begin":303,"end":305},"obj":"IN"},{"id":"T9675","span":{"begin":296,"end":302},"obj":"NN"},{"id":"T9674","span":{"begin":293,"end":295},"obj":"IN"},{"id":"T9673","span":{"begin":282,"end":292},"obj":"NN"},{"id":"T9672","span":{"begin":277,"end":281},"obj":"IN"},{"id":"T9671","span":{"begin":271,"end":276},"obj":"VB"},{"id":"T9670","span":{"begin":268,"end":270},"obj":"PRP"},{"id":"T9669","span":{"begin":255,"end":266},"obj":"NN"},{"id":"T9668","span":{"begin":248,"end":254},"obj":"IN"},{"id":"T9667","span":{"begin":242,"end":247},"obj":"NN"},{"id":"T9666","span":{"begin":229,"end":241},"obj":"JJ"},{"id":"T9665","span":{"begin":223,"end":228},"obj":"PRP-DOLLAR-"},{"id":"T9664","span":{"begin":215,"end":222},"obj":"VB"},{"id":"T9663","span":{"begin":205,"end":214},"obj":"NN"},{"id":"T9662","span":{"begin":200,"end":204},"obj":"JJ"},{"id":"T9661","span":{"begin":194,"end":199},"obj":"DT"},{"id":"T9660","span":{"begin":186,"end":193},"obj":"IN"},{"id":"T9659","span":{"begin":183,"end":185},"obj":"VB"},{"id":"T9658","span":{"begin":174,"end":182},"obj":"NN"},{"id":"T9657","span":{"begin":164,"end":173},"obj":"JJ"},{"id":"T9656","span":{"begin":161,"end":163},"obj":"DT"},{"id":"T9655","span":{"begin":158,"end":159},"obj":"-RRB-"},{"id":"T9654","span":{"begin":156,"end":158},"obj":"CD"},{"id":"T9653","span":{"begin":155,"end":156},"obj":"-LRB-"},{"id":"T9652","span":{"begin":148,"end":154},"obj":"NN"},{"id":"T9651","span":{"begin":144,"end":147},"obj":"CC"},{"id":"T9650","span":{"begin":138,"end":143},"obj":"NN"},{"id":"T9649","span":{"begin":136,"end":137},"obj":"-COMMA-"},{"id":"T9648","span":{"begin":130,"end":136},"obj":"NN"},{"id":"T9647","span":{"begin":120,"end":129},"obj":"VB"},{"id":"T9646","span":{"begin":110,"end":119},"obj":"NN"},{"id":"T9645","span":{"begin":101,"end":109},"obj":"JJ"},{"id":"T9644","span":{"begin":98,"end":100},"obj":"IN"},{"id":"T9643","span":{"begin":90,"end":97},"obj":"NN"},{"id":"T9642","span":{"begin":86,"end":89},"obj":"DT"},{"id":"T9641","span":{"begin":78,"end":85},"obj":"IN"},{"id":"T9640","span":{"begin":68,"end":77},"obj":"NN"},{"id":"T9639","span":{"begin":59,"end":67},"obj":"VB"},{"id":"T9638","span":{"begin":54,"end":58},"obj":"WDT"},{"id":"T9637","span":{"begin":46,"end":53},"obj":"NN"},{"id":"T9636","span":{"begin":33,"end":45},"obj":"JJ"},{"id":"T9635","span":{"begin":31,"end":32},"obj":"DT"},{"id":"T9634","span":{"begin":28,"end":30},"obj":"VB"},{"id":"T9633","span":{"begin":25,"end":27},"obj":"TO"},{"id":"T9632","span":{"begin":14,"end":24},"obj":"VB"},{"id":"T9631","span":{"begin":11,"end":13},"obj":"VB"},{"id":"T9630","span":{"begin":4,"end":10},"obj":"NN"},{"id":"T9629","span":{"begin":0,"end":3},"obj":"NN"}],"relations":[{"id":"R6144","pred":"arg1Of","subj":"T9630","obj":"T9629"},{"id":"R6145","pred":"arg1Of","subj":"T9630","obj":"T9631"},{"id":"R6146","pred":"arg2Of","subj":"T9630","obj":"T9632"},{"id":"R6147","pred":"arg1Of","subj":"T9630","obj":"T9634"},{"id":"R6148","pred":"arg2Of","subj":"T9632","obj":"T9631"},{"id":"R6149","pred":"arg3Of","subj":"T9634","obj":"T9632"},{"id":"R6150","pred":"arg1Of","subj":"T9634","obj":"T9633"},{"id":"R6151","pred":"arg2Of","subj":"T9637","obj":"T9634"},{"id":"R6152","pred":"arg1Of","subj":"T9637","obj":"T9635"},{"id":"R6153","pred":"arg1Of","subj":"T9637","obj":"T9636"},{"id":"R6154","pred":"arg1Of","subj":"T9637","obj":"T9638"},{"id":"R6155","pred":"arg1Of","subj":"T9637","obj":"T9639"},{"id":"R6156","pred":"arg1Of","subj":"T9639","obj":"T9641"},{"id":"R6157","pred":"arg2Of","subj":"T9640","obj":"T9639"},{"id":"R6158","pred":"arg2Of","subj":"T9643","obj":"T9641"},{"id":"R6159","pred":"arg1Of","subj":"T9643","obj":"T9642"},{"id":"R6160","pred":"arg1Of","subj":"T9643","obj":"T9644"},{"id":"R6161","pred":"arg2Of","subj":"T9646","obj":"T9644"},{"id":"R6162","pred":"arg1Of","subj":"T9646","obj":"T9645"},{"id":"R6163","pred":"arg1Of","subj":"T9646","obj":"T9647"},{"id":"R6164","pred":"arg1Of","subj":"T9648","obj":"T9649"},{"id":"R6165","pred":"arg1Of","subj":"T9649","obj":"T9651"},{"id":"R6166","pred":"arg2Of","subj":"T9650","obj":"T9649"},{"id":"R6167","pred":"arg2Of","subj":"T9651","obj":"T9647"},{"id":"R6168","pred":"arg1Of","subj":"T9651","obj":"T9653"},{"id":"R6169","pred":"arg2Of","subj":"T9652","obj":"T9651"},{"id":"R6170","pred":"arg2Of","subj":"T9654","obj":"T9653"},{"id":"R6171","pred":"arg3Of","subj":"T9655","obj":"T9653"},{"id":"R6172","pred":"arg1Of","subj":"T9658","obj":"T9656"},{"id":"R6173","pred":"arg1Of","subj":"T9658","obj":"T9657"},{"id":"R6174","pred":"arg1Of","subj":"T9658","obj":"T9659"},{"id":"R6175","pred":"arg1Of","subj":"T9663","obj":"T9661"},{"id":"R6176","pred":"arg1Of","subj":"T9663","obj":"T9662"},{"id":"R6177","pred":"arg1Of","subj":"T9663","obj":"T9664"},{"id":"R6178","pred":"arg2Of","subj":"T9664","obj":"T9659"},{"id":"R6179","pred":"arg1Of","subj":"T9664","obj":"T9660"},{"id":"R6180","pred":"arg1Of","subj":"T9664","obj":"T9668"},{"id":"R6181","pred":"arg2Of","subj":"T9667","obj":"T9664"},{"id":"R6182","pred":"arg1Of","subj":"T9667","obj":"T9665"},{"id":"R6183","pred":"arg1Of","subj":"T9667","obj":"T9666"},{"id":"R6184","pred":"arg2Of","subj":"T9669","obj":"T9668"},{"id":"R6185","pred":"arg1Of","subj":"T9670","obj":"T9671"},{"id":"R6186","pred":"arg1Of","subj":"T9673","obj":"T9674"},{"id":"R6187","pred":"arg1Of","subj":"T9673","obj":"T9676"},{"id":"R6188","pred":"arg1Of","subj":"T9673","obj":"T9689"},{"id":"R6189","pred":"arg1Of","subj":"T9673","obj":"T9690"},{"id":"R6190","pred":"arg2Of","subj":"T9675","obj":"T9674"},{"id":"R6191","pred":"arg2Of","subj":"T9677","obj":"T9676"},{"id":"R6192","pred":"arg1Of","subj":"T9677","obj":"T9678"},{"id":"R6193","pred":"arg2Of","subj":"T9680","obj":"T9678"},{"id":"R6194","pred":"arg1Of","subj":"T9680","obj":"T9679"},{"id":"R6195","pred":"arg1Of","subj":"T9680","obj":"T9681"},{"id":"R6196","pred":"arg2Of","subj":"T9685","obj":"T9681"},{"id":"R6197","pred":"arg1Of","subj":"T9685","obj":"T9682"},{"id":"R6198","pred":"arg1Of","subj":"T9685","obj":"T9683"},{"id":"R6199","pred":"arg1Of","subj":"T9685","obj":"T9684"},{"id":"R6200","pred":"arg1Of","subj":"T9685","obj":"T9686"},{"id":"R6201","pred":"arg2Of","subj":"T9687","obj":"T9686"},{"id":"R6202","pred":"arg3Of","subj":"T9688","obj":"T9686"},{"id":"R6203","pred":"arg2Of","subj":"T9690","obj":"T9671"},{"id":"R6204","pred":"arg1Of","subj":"T9690","obj":"T9672"},{"id":"R6205","pred":"arg2Of","subj":"T9691","obj":"T9690"},{"id":"R6206","pred":"arg1Of","subj":"T9691","obj":"T9692"},{"id":"R6207","pred":"arg1Of","subj":"T9691","obj":"T9694"},{"id":"R6208","pred":"arg2Of","subj":"T9693","obj":"T9692"},{"id":"R6209","pred":"arg2Of","subj":"T9696","obj":"T9694"},{"id":"R6210","pred":"arg1Of","subj":"T9696","obj":"T9695"},{"id":"R6211","pred":"arg3Of","subj":"T9697","obj":"T9694"},{"id":"R6212","pred":"arg1Of","subj":"T9705","obj":"T9700"},{"id":"R6213","pred":"arg1Of","subj":"T9705","obj":"T9701"},{"id":"R6214","pred":"arg1Of","subj":"T9705","obj":"T9702"},{"id":"R6215","pred":"arg1Of","subj":"T9705","obj":"T9703"},{"id":"R6216","pred":"arg1Of","subj":"T9705","obj":"T9704"},{"id":"R6217","pred":"arg1Of","subj":"T9705","obj":"T9706"},{"id":"R6218","pred":"arg1Of","subj":"T9705","obj":"T9709"},{"id":"R6219","pred":"arg2Of","subj":"T9707","obj":"T9706"},{"id":"R6220","pred":"arg3Of","subj":"T9708","obj":"T9706"},{"id":"R6221","pred":"arg1Of","subj":"T9709","obj":"T9720"},{"id":"R6222","pred":"arg2Of","subj":"T9714","obj":"T9709"},{"id":"R6223","pred":"arg1Of","subj":"T9714","obj":"T9710"},{"id":"R6224","pred":"arg1Of","subj":"T9714","obj":"T9711"},{"id":"R6225","pred":"arg1Of","subj":"T9714","obj":"T9712"},{"id":"R6226","pred":"arg1Of","subj":"T9714","obj":"T9713"},{"id":"R6227","pred":"arg1Of","subj":"T9714","obj":"T9715"},{"id":"R6228","pred":"arg2Of","subj":"T9716","obj":"T9715"},{"id":"R6229","pred":"arg3Of","subj":"T9717","obj":"T9715"},{"id":"R6230","pred":"arg1Of","subj":"T9720","obj":"T9698"},{"id":"R6231","pred":"arg1Of","subj":"T9720","obj":"T9699"},{"id":"R6232","pred":"arg1Of","subj":"T9720","obj":"T9718"},{"id":"R6233","pred":"arg1Of","subj":"T9720","obj":"T9719"},{"id":"R6234","pred":"arg2Of","subj":"T9721","obj":"T9720"},{"id":"R6235","pred":"arg1Of","subj":"T9721","obj":"T9722"},{"id":"R6236","pred":"arg2Of","subj":"T9724","obj":"T9722"},{"id":"R6237","pred":"arg1Of","subj":"T9724","obj":"T9723"},{"id":"R6238","pred":"arg3Of","subj":"T9725","obj":"T9722"},{"id":"R6239","pred":"arg1Of","subj":"T9726","obj":"T9727"},{"id":"R6240","pred":"arg1Of","subj":"T9726","obj":"T9729"},{"id":"R6241","pred":"arg1Of","subj":"T9726","obj":"T9732"},{"id":"R6242","pred":"arg2Of","subj":"T9728","obj":"T9727"},{"id":"R6243","pred":"arg2Of","subj":"T9730","obj":"T9729"},{"id":"R6244","pred":"arg1Of","subj":"T9732","obj":"T9731"},{"id":"R6245","pred":"arg2Of","subj":"T9736","obj":"T9732"},{"id":"R6246","pred":"arg1Of","subj":"T9736","obj":"T9733"},{"id":"R6247","pred":"arg1Of","subj":"T9736","obj":"T9734"},{"id":"R6248","pred":"arg1Of","subj":"T9736","obj":"T9735"},{"id":"R6249","pred":"arg1Of","subj":"T9736","obj":"T9737"},{"id":"R6250","pred":"arg1Of","subj":"T9736","obj":"T9745"},{"id":"R6251","pred":"arg1Of","subj":"T9736","obj":"T9752"},{"id":"R6252","pred":"arg1Of","subj":"T9737","obj":"T9744"},{"id":"R6253","pred":"arg2Of","subj":"T9739","obj":"T9737"},{"id":"R6254","pred":"arg1Of","subj":"T9739","obj":"T9738"},{"id":"R6255","pred":"arg1Of","subj":"T9739","obj":"T9740"},{"id":"R6256","pred":"arg1Of","subj":"T9739","obj":"T9742"},{"id":"R6257","pred":"arg2Of","subj":"T9741","obj":"T9740"},{"id":"R6258","pred":"arg2Of","subj":"T9743","obj":"T9742"},{"id":"R6259","pred":"arg2Of","subj":"T9745","obj":"T9744"},{"id":"R6260","pred":"arg2Of","subj":"T9746","obj":"T9745"},{"id":"R6261","pred":"arg1Of","subj":"T9746","obj":"T9747"},{"id":"R6262","pred":"arg1Of","subj":"T9749","obj":"T9750"},{"id":"R6263","pred":"arg2Of","subj":"T9750","obj":"T9747"},{"id":"R6264","pred":"arg1Of","subj":"T9750","obj":"T9748"},{"id":"R6265","pred":"arg2Of","subj":"T9751","obj":"T9750"},{"id":"R6266","pred":"arg3Of","subj":"T9752","obj":"T9732"},{"id":"R6267","pred":"arg2Of","subj":"T9753","obj":"T9752"},{"id":"R6268","pred":"arg1Of","subj":"T9753","obj":"T9754"},{"id":"R6269","pred":"arg2Of","subj":"T9756","obj":"T9754"},{"id":"R6270","pred":"arg1Of","subj":"T9756","obj":"T9755"},{"id":"R6271","pred":"arg3Of","subj":"T9757","obj":"T9754"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T9214","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T9213","span":{"begin":352,"end":358},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T10267","span":{"begin":0,"end":3},"obj":"http://www.uniprot.org/uniprot/P31751"},{"id":"T10253","span":{"begin":0,"end":3},"obj":"http://www.uniprot.org/uniprot/P31749"},{"id":"T10298","span":{"begin":664,"end":668},"obj":"http://www.uniprot.org/uniprot/P42345"},{"id":"T10297","span":{"begin":573,"end":577},"obj":"http://www.uniprot.org/uniprot/P42345"},{"id":"T10296","span":{"begin":483,"end":487},"obj":"http://www.uniprot.org/uniprot/P42345"},{"id":"T10295","span":{"begin":431,"end":435},"obj":"http://www.uniprot.org/uniprot/P42345"},{"id":"T10294","span":{"begin":337,"end":341},"obj":"http://www.uniprot.org/uniprot/P42345"},{"id":"T10281","span":{"begin":0,"end":3},"obj":"http://www.uniprot.org/uniprot/Q9Y243"},{"id":"T10300","span":{"begin":727,"end":731},"obj":"http://www.uniprot.org/uniprot/P01375"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T9305","span":{"begin":478,"end":482},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T9304","span":{"begin":436,"end":452},"obj":"http://purl.obolibrary.org/obo/GO_0033673"},{"id":"T9303","span":{"begin":68,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T9302","span":{"begin":68,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T9301","span":{"begin":229,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0043066"},{"id":"T9300","span":{"begin":33,"end":45},"obj":"http://purl.obolibrary.org/obo/GO_0043066"},{"id":"T9298","span":{"begin":740,"end":745},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T9292","span":{"begin":138,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0050321"},{"id":"T9270","span":{"begin":672,"end":683},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T9269","span":{"begin":537,"end":548},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T9268","span":{"begin":386,"end":397},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T9267","span":{"begin":255,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T9249","span":{"begin":672,"end":683},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T9248","span":{"begin":537,"end":548},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T9247","span":{"begin":386,"end":397},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T9246","span":{"begin":255,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0070266"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T9319","span":{"begin":478,"end":482},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T9316","span":{"begin":138,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0050321"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T9329","span":{"begin":296,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_0031931"},{"id":"T9328","span":{"begin":130,"end":136},"obj":"http://purl.obolibrary.org/obo/GO_0031931"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
sentences
{"project":"sentences","denotations":[{"id":"T9098","span":{"begin":560,"end":756},"obj":"Sentence"},{"id":"T9097","span":{"begin":409,"end":559},"obj":"Sentence"},{"id":"T9096","span":{"begin":268,"end":408},"obj":"Sentence"},{"id":"T9095","span":{"begin":161,"end":267},"obj":"Sentence"},{"id":"T9094","span":{"begin":0,"end":160},"obj":"Sentence"},{"id":"T140","span":{"begin":0,"end":160},"obj":"Sentence"},{"id":"T141","span":{"begin":161,"end":267},"obj":"Sentence"},{"id":"T142","span":{"begin":268,"end":408},"obj":"Sentence"},{"id":"T143","span":{"begin":409,"end":559},"obj":"Sentence"},{"id":"T144","span":{"begin":560,"end":756},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
simple1
{"project":"simple1","denotations":[{"id":"T9350","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T9349","span":{"begin":352,"end":358},"obj":"Protein"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T10218","span":{"begin":320,"end":329},"obj":"Negative_regulation"},{"id":"T10188","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T10187","span":{"begin":352,"end":358},"obj":"Protein"}],"relations":[{"id":"R6666","pred":"themeOf","subj":"T10187","obj":"T10218"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T10475","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T10474","span":{"begin":352,"end":358},"obj":"Protein"},{"id":"T10505","span":{"begin":732,"end":739},"obj":"Positive_regulation"},{"id":"T10504","span":{"begin":320,"end":329},"obj":"Negative_regulation"}],"relations":[{"id":"R6783","pred":"themeOf","subj":"T10474","obj":"T10504"},{"id":"R6784","pred":"themeOf","subj":"T10475","obj":"T10505"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T10331","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T10330","span":{"begin":352,"end":358},"obj":"Protein"},{"id":"T10362","span":{"begin":732,"end":739},"obj":"Positive_regulation"},{"id":"T10361","span":{"begin":320,"end":329},"obj":"Negative_regulation"}],"relations":[{"id":"R6712","pred":"themeOf","subj":"T10330","obj":"T10361"},{"id":"R6713","pred":"themeOf","subj":"T10331","obj":"T10362"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T10920","span":{"begin":586,"end":589},"obj":"Protein"},{"id":"T10909","span":{"begin":293,"end":302},"obj":"Entity"},{"id":"T10906","span":{"begin":320,"end":407},"obj":"Entity"},{"id":"T10882","span":{"begin":664,"end":668},"obj":"Protein"},{"id":"T10876","span":{"begin":130,"end":136},"obj":"Entity"},{"id":"T10870","span":{"begin":352,"end":363},"obj":"Protein"},{"id":"T10867","span":{"begin":469,"end":509},"obj":"Protein"},{"id":"T10866","span":{"begin":337,"end":341},"obj":"Protein"},{"id":"T10861","span":{"begin":0,"end":10},"obj":"Protein"},{"id":"T10857","span":{"begin":747,"end":750},"obj":"Protein"},{"id":"T10856","span":{"begin":443,"end":452},"obj":"Entity"},{"id":"T10855","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T10848","span":{"begin":573,"end":577},"obj":"Protein"},{"id":"T10845","span":{"begin":333,"end":407},"obj":"Entity"},{"id":"T10841","span":{"begin":443,"end":464},"obj":"Entity"},{"id":"T10839","span":{"begin":31,"end":159},"obj":"Protein"},{"id":"T10835","span":{"begin":420,"end":442},"obj":"Protein"},{"id":"T10834","span":{"begin":0,"end":3},"obj":"Protein"},{"id":"T10831","span":{"begin":698,"end":703},"obj":"Entity"},{"id":"T10830","span":{"begin":488,"end":497},"obj":"Entity"},{"id":"T10822","span":{"begin":138,"end":143},"obj":"Protein"},{"id":"T10821","span":{"begin":627,"end":636},"obj":"Entity"},{"id":"T10820","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T10817","span":{"begin":303,"end":316},"obj":"Entity"},{"id":"T10816","span":{"begin":570,"end":586},"obj":"Entity"},{"id":"T10811","span":{"begin":194,"end":214},"obj":"Entity"},{"id":"T10802","span":{"begin":469,"end":509},"obj":"Entity"},{"id":"T10796","span":{"begin":714,"end":722},"obj":"Entity"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
bionlp-st-ge-2016-spacy-parsed
{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T11323","span":{"begin":755,"end":756},"obj":"."},{"id":"T11322","span":{"begin":754,"end":755},"obj":"-RRB-"},{"id":"T11321","span":{"begin":752,"end":754},"obj":"NNP"},{"id":"T11320","span":{"begin":747,"end":751},"obj":"NNP"},{"id":"T11319","span":{"begin":746,"end":747},"obj":"-LRB-"},{"id":"T11318","span":{"begin":740,"end":745},"obj":"NN"},{"id":"T11317","span":{"begin":732,"end":739},"obj":"VBD"},{"id":"T11316","span":{"begin":727,"end":731},"obj":"NNP"},{"id":"T11315","span":{"begin":723,"end":726},"obj":"CC"},{"id":"T11314","span":{"begin":714,"end":722},"obj":"NNP"},{"id":"T11313","span":{"begin":709,"end":713},"obj":"DT"},{"id":"T11312","span":{"begin":704,"end":708},"obj":"IN"},{"id":"T11311","span":{"begin":698,"end":703},"obj":"NNS"},{"id":"T11310","span":{"begin":687,"end":697},"obj":"VBG"},{"id":"T11309","span":{"begin":684,"end":686},"obj":"IN"},{"id":"T11308","span":{"begin":672,"end":683},"obj":"NN"},{"id":"T11307","span":{"begin":669,"end":671},"obj":"IN"},{"id":"T11306","span":{"begin":664,"end":668},"obj":"NNP"},{"id":"T11305","span":{"begin":660,"end":663},"obj":"IN"},{"id":"T11304","span":{"begin":655,"end":659},"obj":"NN"},{"id":"T11291","span":{"begin":560,"end":569},"obj":"NNP"},{"id":"T11290","span":{"begin":558,"end":559},"obj":"."},{"id":"T11289","span":{"begin":557,"end":558},"obj":"-RRB-"},{"id":"T11288","span":{"begin":555,"end":557},"obj":"NNP"},{"id":"T11287","span":{"begin":550,"end":554},"obj":"NNP"},{"id":"T11286","span":{"begin":549,"end":550},"obj":"-LRB-"},{"id":"T11285","span":{"begin":537,"end":548},"obj":"NN"},{"id":"T11284","span":{"begin":527,"end":536},"obj":"VBN"},{"id":"T11283","span":{"begin":515,"end":526},"obj":"RB"},{"id":"T11282","span":{"begin":510,"end":514},"obj":"RB"},{"id":"T11281","span":{"begin":508,"end":509},"obj":"NNP"},{"id":"T11280","span":{"begin":506,"end":508},"obj":"CD"},{"id":"T11279","span":{"begin":505,"end":506},"obj":"NNP"},{"id":"T11278","span":{"begin":498,"end":504},"obj":"NN"},{"id":"T11277","span":{"begin":488,"end":497},"obj":"NN"},{"id":"T11276","span":{"begin":478,"end":487},"obj":"JJ"},{"id":"T11275","span":{"begin":473,"end":477},"obj":"JJ"},{"id":"T11274","span":{"begin":469,"end":472},"obj":"DT"},{"id":"T11273","span":{"begin":465,"end":468},"obj":"CC"},{"id":"T11272","span":{"begin":463,"end":464},"obj":"NNP"},{"id":"T11271","span":{"begin":461,"end":463},"obj":"CD"},{"id":"T11270","span":{"begin":460,"end":461},"obj":"NNP"},{"id":"T11269","span":{"begin":453,"end":459},"obj":"NNP"},{"id":"T11268","span":{"begin":443,"end":452},"obj":"NN"},{"id":"T11267","span":{"begin":436,"end":442},"obj":"NN"},{"id":"T11266","span":{"begin":431,"end":435},"obj":"NNP"},{"id":"T11265","span":{"begin":424,"end":430},"obj":"JJ"},{"id":"T11264","span":{"begin":420,"end":423},"obj":"DT"},{"id":"T11263","span":{"begin":418,"end":419},"obj":","},{"id":"T11262","span":{"begin":409,"end":418},"obj":"RB"},{"id":"T11261","span":{"begin":407,"end":408},"obj":"."},{"id":"T11260","span":{"begin":406,"end":407},"obj":"-RRB-"},{"id":"T11259","span":{"begin":404,"end":406},"obj":"NNP"},{"id":"T11258","span":{"begin":399,"end":403},"obj":"NNP"},{"id":"T11257","span":{"begin":398,"end":399},"obj":"-LRB-"},{"id":"T11256","span":{"begin":386,"end":397},"obj":"NN"},{"id":"T11255","span":{"begin":381,"end":385},"obj":"IN"},{"id":"T11254","span":{"begin":375,"end":380},"obj":"NNS"},{"id":"T11253","span":{"begin":365,"end":374},"obj":"VBN"},{"id":"T11252","span":{"begin":363,"end":364},"obj":","},{"id":"T11251","span":{"begin":362,"end":363},"obj":"NNP"},{"id":"T11250","span":{"begin":360,"end":362},"obj":"CD"},{"id":"T11249","span":{"begin":359,"end":360},"obj":"NNP"},{"id":"T11248","span":{"begin":352,"end":358},"obj":"NNP"},{"id":"T11247","span":{"begin":342,"end":351},"obj":"NN"},{"id":"T11246","span":{"begin":337,"end":341},"obj":"NNP"},{"id":"T11245","span":{"begin":333,"end":336},"obj":"DT"},{"id":"T11244","span":{"begin":330,"end":332},"obj":"IN"},{"id":"T11243","span":{"begin":320,"end":329},"obj":"NN"},{"id":"T11242","span":{"begin":317,"end":319},"obj":"DT"},{"id":"T11241","span":{"begin":315,"end":316},"obj":","},{"id":"T11240","span":{"begin":306,"end":315},"obj":"NN"},{"id":"T11239","span":{"begin":303,"end":305},"obj":"IN"},{"id":"T11238","span":{"begin":296,"end":302},"obj":"NNP"},{"id":"T11237","span":{"begin":293,"end":295},"obj":"IN"},{"id":"T11236","span":{"begin":282,"end":292},"obj":"NN"},{"id":"T11235","span":{"begin":277,"end":281},"obj":"IN"},{"id":"T11234","span":{"begin":271,"end":276},"obj":"VBD"},{"id":"T11233","span":{"begin":268,"end":270},"obj":"PRP"},{"id":"T11232","span":{"begin":266,"end":267},"obj":"."},{"id":"T11231","span":{"begin":255,"end":266},"obj":"NN"},{"id":"T11230","span":{"begin":248,"end":254},"obj":"IN"},{"id":"T11229","span":{"begin":242,"end":247},"obj":"NNS"},{"id":"T11228","span":{"begin":229,"end":241},"obj":"JJ"},{"id":"T11227","span":{"begin":223,"end":228},"obj":"PRP$"},{"id":"T11226","span":{"begin":215,"end":222},"obj":"VBP"},{"id":"T11225","span":{"begin":205,"end":214},"obj":"NNS"},{"id":"T11224","span":{"begin":200,"end":204},"obj":"JJ"},{"id":"T11223","span":{"begin":194,"end":199},"obj":"DT"},{"id":"T11222","span":{"begin":186,"end":193},"obj":"IN"},{"id":"T11221","span":{"begin":183,"end":185},"obj":"VBZ"},{"id":"T11220","span":{"begin":174,"end":182},"obj":"NN"},{"id":"T11219","span":{"begin":164,"end":173},"obj":"JJ"},{"id":"T11218","span":{"begin":161,"end":163},"obj":"DT"},{"id":"T11217","span":{"begin":159,"end":160},"obj":"."},{"id":"T11216","span":{"begin":158,"end":159},"obj":"NNP"},{"id":"T11215","span":{"begin":156,"end":158},"obj":"CD"},{"id":"T11214","span":{"begin":155,"end":156},"obj":"NNP"},{"id":"T11213","span":{"begin":148,"end":154},"obj":"NNS"},{"id":"T11212","span":{"begin":144,"end":147},"obj":"CC"},{"id":"T11211","span":{"begin":138,"end":143},"obj":"NNP"},{"id":"T11210","span":{"begin":136,"end":137},"obj":","},{"id":"T11209","span":{"begin":130,"end":136},"obj":"NNP"},{"id":"T11208","span":{"begin":120,"end":129},"obj":"VBG"},{"id":"T11207","span":{"begin":110,"end":119},"obj":"NNS"},{"id":"T11206","span":{"begin":101,"end":109},"obj":"JJ"},{"id":"T11205","span":{"begin":98,"end":100},"obj":"IN"},{"id":"T11204","span":{"begin":90,"end":97},"obj":"NN"},{"id":"T11203","span":{"begin":86,"end":89},"obj":"DT"},{"id":"T11202","span":{"begin":78,"end":85},"obj":"IN"},{"id":"T11201","span":{"begin":68,"end":77},"obj":"NN"},{"id":"T11200","span":{"begin":59,"end":67},"obj":"VBZ"},{"id":"T11199","span":{"begin":54,"end":58},"obj":"WDT"},{"id":"T11198","span":{"begin":46,"end":53},"obj":"NN"},{"id":"T11197","span":{"begin":33,"end":45},"obj":"JJ"},{"id":"T11196","span":{"begin":31,"end":32},"obj":"DT"},{"id":"T11195","span":{"begin":28,"end":30},"obj":"VB"},{"id":"T11194","span":{"begin":25,"end":27},"obj":"TO"},{"id":"T11193","span":{"begin":14,"end":24},"obj":"VBN"},{"id":"T11192","span":{"begin":11,"end":13},"obj":"VBZ"},{"id":"T11191","span":{"begin":4,"end":10},"obj":"NN"},{"id":"T11190","span":{"begin":0,"end":3},"obj":"NNP"},{"id":"T11303","span":{"begin":653,"end":654},"obj":"DT"},{"id":"T11302","span":{"begin":642,"end":652},"obj":"VBG"},{"id":"T11301","span":{"begin":637,"end":641},"obj":"NNS"},{"id":"T11300","span":{"begin":627,"end":636},"obj":"NN"},{"id":"T11299","span":{"begin":612,"end":626},"obj":"JJ"},{"id":"T11298","span":{"begin":608,"end":611},"obj":"DT"},{"id":"T11297","span":{"begin":598,"end":607},"obj":"VBD"},{"id":"T11296","span":{"begin":590,"end":597},"obj":"JJ"},{"id":"T11295","span":{"begin":584,"end":589},"obj":"NNP"},{"id":"T11294","span":{"begin":578,"end":583},"obj":"VBG"},{"id":"T11293","span":{"begin":573,"end":577},"obj":"NNP"},{"id":"T11292","span":{"begin":570,"end":572},"obj":"IN"}],"relations":[{"id":"R7227","pred":"compound","subj":"T11190","obj":"T11191"},{"id":"R7228","pred":"nsubjpass","subj":"T11191","obj":"T11193"},{"id":"R7229","pred":"auxpass","subj":"T11192","obj":"T11193"},{"id":"R7230","pred":"ROOT","subj":"T11193","obj":"T11193"},{"id":"R7231","pred":"aux","subj":"T11194","obj":"T11195"},{"id":"R7232","pred":"xcomp","subj":"T11195","obj":"T11193"},{"id":"R7233","pred":"det","subj":"T11196","obj":"T11198"},{"id":"R7234","pred":"amod","subj":"T11197","obj":"T11198"},{"id":"R7235","pred":"attr","subj":"T11198","obj":"T11195"},{"id":"R7236","pred":"nsubj","subj":"T11199","obj":"T11200"},{"id":"R7237","pred":"relcl","subj":"T11200","obj":"T11198"},{"id":"R7238","pred":"dobj","subj":"T11201","obj":"T11200"},{"id":"R7239","pred":"prep","subj":"T11202","obj":"T11200"},{"id":"R7240","pred":"det","subj":"T11203","obj":"T11204"},{"id":"R7241","pred":"pobj","subj":"T11204","obj":"T11202"},{"id":"R7242","pred":"prep","subj":"T11205","obj":"T11204"},{"id":"R7243","pred":"amod","subj":"T11206","obj":"T11207"},{"id":"R7244","pred":"pobj","subj":"T11207","obj":"T11205"},{"id":"R7245","pred":"prep","subj":"T11208","obj":"T11207"},{"id":"R7246","pred":"pobj","subj":"T11209","obj":"T11208"},{"id":"R7247","pred":"punct","subj":"T11210","obj":"T11209"},{"id":"R7248","pred":"conj","subj":"T11211","obj":"T11209"},{"id":"R7249","pred":"cc","subj":"T11212","obj":"T11211"},{"id":"R7250","pred":"conj","subj":"T11213","obj":"T11211"},{"id":"R7251","pred":"nmod","subj":"T11214","obj":"T11216"},{"id":"R7252","pred":"nummod","subj":"T11215","obj":"T11216"},{"id":"R7253","pred":"appos","subj":"T11216","obj":"T11213"},{"id":"R7254","pred":"punct","subj":"T11217","obj":"T11193"},{"id":"R7255","pred":"det","subj":"T11218","obj":"T11220"},{"id":"R7256","pred":"amod","subj":"T11219","obj":"T11220"},{"id":"R7257","pred":"nsubj","subj":"T11220","obj":"T11221"},{"id":"R7258","pred":"ROOT","subj":"T11221","obj":"T11221"},{"id":"R7259","pred":"mark","subj":"T11222","obj":"T11226"},{"id":"R7260","pred":"det","subj":"T11223","obj":"T11225"},{"id":"R7261","pred":"amod","subj":"T11224","obj":"T11225"},{"id":"R7262","pred":"nsubj","subj":"T11225","obj":"T11226"},{"id":"R7263","pred":"ccomp","subj":"T11226","obj":"T11221"},{"id":"R7264","pred":"poss","subj":"T11227","obj":"T11229"},{"id":"R7265","pred":"amod","subj":"T11228","obj":"T11229"},{"id":"R7266","pred":"dobj","subj":"T11229","obj":"T11226"},{"id":"R7267","pred":"prep","subj":"T11230","obj":"T11226"},{"id":"R7268","pred":"pobj","subj":"T11231","obj":"T11230"},{"id":"R7269","pred":"punct","subj":"T11232","obj":"T11221"},{"id":"R7270","pred":"nsubj","subj":"T11233","obj":"T11234"},{"id":"R7271","pred":"ROOT","subj":"T11234","obj":"T11234"},{"id":"R7272","pred":"det","subj":"T11235","obj":"T11236"},{"id":"R7273","pred":"dobj","subj":"T11236","obj":"T11234"},{"id":"R7274","pred":"prep","subj":"T11237","obj":"T11236"},{"id":"R7275","pred":"pobj","subj":"T11238","obj":"T11237"},{"id":"R7276","pred":"prep","subj":"T11239","obj":"T11236"},{"id":"R7277","pred":"pobj","subj":"T11240","obj":"T11239"},{"id":"R7278","pred":"punct","subj":"T11241","obj":"T11240"},{"id":"R7279","pred":"det","subj":"T11242","obj":"T11243"},{"id":"R7280","pred":"conj","subj":"T11243","obj":"T11236"},{"id":"R7281","pred":"prep","subj":"T11244","obj":"T11243"},{"id":"R7282","pred":"det","subj":"T11245","obj":"T11247"},{"id":"R7283","pred":"compound","subj":"T11246","obj":"T11247"},{"id":"R7284","pred":"pobj","subj":"T11247","obj":"T11244"},{"id":"R7285","pred":"compound","subj":"T11248","obj":"T11249"},{"id":"R7286","pred":"appos","subj":"T11249","obj":"T11247"},{"id":"R7287","pred":"nummod","subj":"T11250","obj":"T11251"},{"id":"R7288","pred":"appos","subj":"T11251","obj":"T11247"},{"id":"R7289","pred":"punct","subj":"T11252","obj":"T11251"},{"id":"R7290","pred":"amod","subj":"T11253","obj":"T11254"},{"id":"R7291","pred":"appos","subj":"T11254","obj":"T11247"},{"id":"R7294","pred":"punct","subj":"T11257","obj":"T11256"},{"id":"R7295","pred":"compound","subj":"T11258","obj":"T11259"},{"id":"R7296","pred":"appos","subj":"T11259","obj":"T11256"},{"id":"R7297","pred":"punct","subj":"T11260","obj":"T11256"},{"id":"R7298","pred":"punct","subj":"T11261","obj":"T11234"},{"id":"R7299","pred":"advmod","subj":"T11262","obj":"T11284"},{"id":"R7300","pred":"punct","subj":"T11263","obj":"T11284"},{"id":"R7301","pred":"det","subj":"T11264","obj":"T11268"},{"id":"R7302","pred":"amod","subj":"T11265","obj":"T11268"},{"id":"R7303","pred":"compound","subj":"T11266","obj":"T11268"},{"id":"R7304","pred":"compound","subj":"T11267","obj":"T11268"},{"id":"R7305","pred":"nsubj","subj":"T11268","obj":"T11284"},{"id":"R7306","pred":"compound","subj":"T11269","obj":"T11270"},{"id":"R7307","pred":"appos","subj":"T11270","obj":"T11268"},{"id":"R7308","pred":"nummod","subj":"T11271","obj":"T11272"},{"id":"R7309","pred":"appos","subj":"T11272","obj":"T11270"},{"id":"R7310","pred":"cc","subj":"T11273","obj":"T11272"},{"id":"R7311","pred":"det","subj":"T11274","obj":"T11277"},{"id":"R7312","pred":"amod","subj":"T11275","obj":"T11277"},{"id":"R7313","pred":"amod","subj":"T11276","obj":"T11277"},{"id":"R7314","pred":"compound","subj":"T11277","obj":"T11278"},{"id":"R7315","pred":"compound","subj":"T11278","obj":"T11279"},{"id":"R7316","pred":"compound","subj":"T11279","obj":"T11281"},{"id":"R7317","pred":"compound","subj":"T11280","obj":"T11281"},{"id":"R7318","pred":"conj","subj":"T11281","obj":"T11272"},{"id":"R7319","pred":"advmod","subj":"T11282","obj":"T11284"},{"id":"R7320","pred":"advmod","subj":"T11283","obj":"T11284"},{"id":"R7321","pred":"ROOT","subj":"T11284","obj":"T11284"},{"id":"R7322","pred":"dobj","subj":"T11285","obj":"T11284"},{"id":"R7323","pred":"punct","subj":"T11286","obj":"T11288"},{"id":"R7324","pred":"compound","subj":"T11287","obj":"T11288"},{"id":"R7325","pred":"appos","subj":"T11288","obj":"T11285"},{"id":"R7326","pred":"punct","subj":"T11289","obj":"T11288"},{"id":"R7327","pred":"punct","subj":"T11290","obj":"T11284"},{"id":"R7328","pred":"nsubj","subj":"T11291","obj":"T11297"},{"id":"R7329","pred":"prep","subj":"T11292","obj":"T11291"},{"id":"R7330","pred":"pobj","subj":"T11293","obj":"T11292"},{"id":"R7331","pred":"nsubj","subj":"T11294","obj":"T11297"},{"id":"R7332","pred":"compound","subj":"T11295","obj":"T11296"},{"id":"R7333","pred":"advmod","subj":"T11296","obj":"T11297"},{"id":"R7334","pred":"ROOT","subj":"T11297","obj":"T11297"},{"id":"R7335","pred":"det","subj":"T11298","obj":"T11301"},{"id":"R7336","pred":"amod","subj":"T11299","obj":"T11301"},{"id":"R7337","pred":"compound","subj":"T11300","obj":"T11301"},{"id":"R7338","pred":"dobj","subj":"T11301","obj":"T11297"},{"id":"R7339","pred":"acl","subj":"T11302","obj":"T11301"},{"id":"R7340","pred":"det","subj":"T11303","obj":"T11304"},{"id":"R7341","pred":"dobj","subj":"T11304","obj":"T11302"},{"id":"R7342","pred":"prep","subj":"T11305","obj":"T11304"},{"id":"R7343","pred":"pobj","subj":"T11306","obj":"T11305"},{"id":"R7344","pred":"prep","subj":"T11307","obj":"T11304"},{"id":"R7345","pred":"pobj","subj":"T11308","obj":"T11307"},{"id":"R7346","pred":"prep","subj":"T11309","obj":"T11304"},{"id":"R7347","pred":"pcomp","subj":"T11310","obj":"T11309"},{"id":"R7348","pred":"dobj","subj":"T11311","obj":"T11310"},{"id":"R7349","pred":"prep","subj":"T11312","obj":"T11310"},{"id":"R7350","pred":"preconj","subj":"T11313","obj":"T11314"},{"id":"R7351","pred":"pobj","subj":"T11314","obj":"T11312"},{"id":"R7352","pred":"cc","subj":"T11315","obj":"T11314"},{"id":"R7353","pred":"conj","subj":"T11316","obj":"T11314"},{"id":"R7354","pred":"conj","subj":"T11317","obj":"T11297"},{"id":"R7355","pred":"dobj","subj":"T11318","obj":"T11317"},{"id":"R7356","pred":"punct","subj":"T11319","obj":"T11321"},{"id":"R7357","pred":"compound","subj":"T11320","obj":"T11321"},{"id":"R7358","pred":"oprd","subj":"T11321","obj":"T11317"},{"id":"R7359","pred":"punct","subj":"T11322","obj":"T11321"},{"id":"R7360","pred":"punct","subj":"T11323","obj":"T11297"},{"id":"R7292","pred":"prep","subj":"T11255","obj":"T11254"},{"id":"R7293","pred":"pobj","subj":"T11256","obj":"T11255"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
bionlp-st-ge-2016-test-tees
{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T10580","span":{"begin":560,"end":569},"obj":"Negative_regulation"},{"id":"T10579","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T10578","span":{"begin":714,"end":722},"obj":"Protein"},{"id":"T10577","span":{"begin":664,"end":668},"obj":"Protein"},{"id":"T10576","span":{"begin":573,"end":589},"obj":"Protein"},{"id":"T10575","span":{"begin":488,"end":497},"obj":"Negative_regulation"},{"id":"T10574","span":{"begin":488,"end":497},"obj":"Negative_regulation"},{"id":"T10573","span":{"begin":443,"end":452},"obj":"Negative_regulation"},{"id":"T10572","span":{"begin":483,"end":487},"obj":"Protein"},{"id":"T10571","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T10570","span":{"begin":431,"end":442},"obj":"Protein"},{"id":"T10569","span":{"begin":320,"end":329},"obj":"Negative_regulation"},{"id":"T10568","span":{"begin":282,"end":292},"obj":"Negative_regulation"},{"id":"T10567","span":{"begin":337,"end":341},"obj":"Protein"},{"id":"T10566","span":{"begin":296,"end":302},"obj":"Protein"},{"id":"T10565","span":{"begin":0,"end":10},"obj":"Protein"}],"relations":[{"id":"R6827","pred":"themeOf","subj":"T10566","obj":"T10568"},{"id":"R6828","pred":"themeOf","subj":"T10567","obj":"T10569"},{"id":"R6829","pred":"themeOf","subj":"T10570","obj":"T10573"},{"id":"R6830","pred":"themeOf","subj":"T10571","obj":"T10574"},{"id":"R6831","pred":"themeOf","subj":"T10572","obj":"T10575"},{"id":"R6832","pred":"themeOf","subj":"T10576","obj":"T10580"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}
test3
{"project":"test3","denotations":[{"id":"T8980","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T8979","span":{"begin":352,"end":358},"obj":"Protein"},{"id":"T9035","span":{"begin":732,"end":739},"obj":"Positive_regulation"},{"id":"T9034","span":{"begin":727,"end":731},"obj":"Protein"},{"id":"T9033","span":{"begin":560,"end":569},"obj":"Negative_regulation"},{"id":"T9032","span":{"begin":527,"end":536},"obj":"Negative_regulation"},{"id":"T9031","span":{"begin":488,"end":497},"obj":"Negative_regulation"},{"id":"T9030","span":{"begin":443,"end":452},"obj":"Negative_regulation"},{"id":"T9029","span":{"begin":352,"end":358},"obj":"Protein"},{"id":"T9028","span":{"begin":320,"end":329},"obj":"Negative_regulation"}],"relations":[{"id":"R5834","pred":"themeOf","subj":"T9029","obj":"T9028"}],"text":"Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]. An important question is whether these same molecules reverse their pro-survival roles during necroptosis. We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C). Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C). Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D)."}