PMC:3567831 / 16565-17591 JSONTXT

{"project":"0_colil","denotations":[{"id":"22761504-18202887-6872","span":{"begin":336,"end":338},"obj":"18202887"},{"id":"22761504-17483110-6873","span":{"begin":552,"end":553},"obj":"17483110"},{"id":"22761504-16053960-6874","span":{"begin":555,"end":556},"obj":"16053960"},{"id":"22761504-9626846-6875","span":{"begin":1022,"end":1024},"obj":"9626846"}],"text":"The treatment strategy for obstructive HCM is significantly dependent on the degree of symptoms due to obstruction. The benefits and risks of each procedure should be analysed scientifically on the basis of current evidence. It is commonly accepted that medical therapy remains the first-line treatment in the majority of HCM patients [13], but if the peak instantaneous LVOT gradient is ≥50 mmHg (at rest or with provocation) and the symptoms cannot be managed with medications, septal reduction therapy is strongly recommended to avoid sudden death [5, 6]. In this retrospective study, we found that LVOT gradient was low (\u003c50 mmHg) in six patients (six of 93) at rest but became much higher (\u003e50 mmHg) after provocation. These patients all had drug-refractory symptoms after activity and underwent myectomy with a very good outcome. Therefore, some labile obstructive HCM patients also need surgical intervention. A provocation test is very important for patients in order not to miss the diagnosis of obstructive HCM [14]."}

{"project":"TEST0","denotations":[{"id":"22761504-111-117-6872","span":{"begin":336,"end":338},"obj":"[\"18202887\"]"},{"id":"22761504-233-238-6873","span":{"begin":552,"end":553},"obj":"[\"17483110\"]"},{"id":"22761504-236-241-6874","span":{"begin":555,"end":556},"obj":"[\"16053960\"]"},{"id":"22761504-105-111-6875","span":{"begin":1022,"end":1024},"obj":"[\"9626846\"]"}],"text":"The treatment strategy for obstructive HCM is significantly dependent on the degree of symptoms due to obstruction. The benefits and risks of each procedure should be analysed scientifically on the basis of current evidence. It is commonly accepted that medical therapy remains the first-line treatment in the majority of HCM patients [13], but if the peak instantaneous LVOT gradient is ≥50 mmHg (at rest or with provocation) and the symptoms cannot be managed with medications, septal reduction therapy is strongly recommended to avoid sudden death [5, 6]. In this retrospective study, we found that LVOT gradient was low (\u003c50 mmHg) in six patients (six of 93) at rest but became much higher (\u003e50 mmHg) after provocation. These patients all had drug-refractory symptoms after activity and underwent myectomy with a very good outcome. Therefore, some labile obstructive HCM patients also need surgical intervention. A provocation test is very important for patients in order not to miss the diagnosis of obstructive HCM [14]."}

{"project":"2_test","denotations":[{"id":"22761504-18202887-28905038","span":{"begin":336,"end":338},"obj":"18202887"},{"id":"22761504-17483110-28905039","span":{"begin":552,"end":553},"obj":"17483110"},{"id":"22761504-16053960-28905040","span":{"begin":555,"end":556},"obj":"16053960"},{"id":"22761504-9626846-28905041","span":{"begin":1022,"end":1024},"obj":"9626846"}],"text":"The treatment strategy for obstructive HCM is significantly dependent on the degree of symptoms due to obstruction. The benefits and risks of each procedure should be analysed scientifically on the basis of current evidence. It is commonly accepted that medical therapy remains the first-line treatment in the majority of HCM patients [13], but if the peak instantaneous LVOT gradient is ≥50 mmHg (at rest or with provocation) and the symptoms cannot be managed with medications, septal reduction therapy is strongly recommended to avoid sudden death [5, 6]. In this retrospective study, we found that LVOT gradient was low (\u003c50 mmHg) in six patients (six of 93) at rest but became much higher (\u003e50 mmHg) after provocation. These patients all had drug-refractory symptoms after activity and underwent myectomy with a very good outcome. Therefore, some labile obstructive HCM patients also need surgical intervention. A provocation test is very important for patients in order not to miss the diagnosis of obstructive HCM [14]."}

{"project":"MyTest","denotations":[{"id":"22761504-18202887-28905038","span":{"begin":336,"end":338},"obj":"18202887"},{"id":"22761504-17483110-28905039","span":{"begin":552,"end":553},"obj":"17483110"},{"id":"22761504-16053960-28905040","span":{"begin":555,"end":556},"obj":"16053960"},{"id":"22761504-9626846-28905041","span":{"begin":1022,"end":1024},"obj":"9626846"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The treatment strategy for obstructive HCM is significantly dependent on the degree of symptoms due to obstruction. The benefits and risks of each procedure should be analysed scientifically on the basis of current evidence. It is commonly accepted that medical therapy remains the first-line treatment in the majority of HCM patients [13], but if the peak instantaneous LVOT gradient is ≥50 mmHg (at rest or with provocation) and the symptoms cannot be managed with medications, septal reduction therapy is strongly recommended to avoid sudden death [5, 6]. In this retrospective study, we found that LVOT gradient was low (\u003c50 mmHg) in six patients (six of 93) at rest but became much higher (\u003e50 mmHg) after provocation. These patients all had drug-refractory symptoms after activity and underwent myectomy with a very good outcome. Therefore, some labile obstructive HCM patients also need surgical intervention. A provocation test is very important for patients in order not to miss the diagnosis of obstructive HCM [14]."}

{"project":"testtesttest","denotations":[{"id":"T128","span":{"begin":371,"end":375},"obj":"Body_part"},{"id":"T129","span":{"begin":602,"end":606},"obj":"Body_part"}],"attributes":[{"id":"A128","pred":"uberon_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/UBERON_0005956"},{"id":"A129","pred":"uberon_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/UBERON_0005956"}],"text":"The treatment strategy for obstructive HCM is significantly dependent on the degree of symptoms due to obstruction. The benefits and risks of each procedure should be analysed scientifically on the basis of current evidence. It is commonly accepted that medical therapy remains the first-line treatment in the majority of HCM patients [13], but if the peak instantaneous LVOT gradient is ≥50 mmHg (at rest or with provocation) and the symptoms cannot be managed with medications, septal reduction therapy is strongly recommended to avoid sudden death [5, 6]. In this retrospective study, we found that LVOT gradient was low (\u003c50 mmHg) in six patients (six of 93) at rest but became much higher (\u003e50 mmHg) after provocation. These patients all had drug-refractory symptoms after activity and underwent myectomy with a very good outcome. Therefore, some labile obstructive HCM patients also need surgical intervention. A provocation test is very important for patients in order not to miss the diagnosis of obstructive HCM [14]."}