PMC:3543920 / 914-1431 JSONTXT

{"project":"2_test","denotations":[{"id":"23346032-19861545-44837241","span":{"begin":343,"end":344},"obj":"19861545"},{"id":"23346032-19684571-44837242","span":{"begin":346,"end":347},"obj":"19684571"}],"text":"Introduction\nWhole exome sequencing (WES) is a technique to selectively capture and sequence the coding regions of all annotated protein-coding genes. Coupled with next-generation sequencing (NGS) platforms, it enables the analysis of functional regions of the human genome with unprecedented efficiency. Since its first reported application [1, 2], WES has emerged as a powerful and popular tool for researchers elucidating genetic variants underlying human diseases (Fig. 1) despite certain limitations (see below)."}