PMC:3506840 / 7344-8264 JSONTXT

{"project":"AxD_symptoms","denotations":[{"id":"T33","span":{"begin":167,"end":180},"obj":"Phenotype"},{"id":"T34","span":{"begin":186,"end":195},"obj":"Phenotype"}],"attributes":[{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0004322"},{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0002650"}],"text":"It is noteworthy that the bulbar symptom of this patient regressed spontaneously. She is now 25 years old, and is absolutely free of neurological symptoms, except for short stature with scoliosis, presumably a sign of AxD [9]. This case suggests that the symptoms of AxD can be self-remitting, unlike those of other neurodegenerative disorders, and that the prognosis might not necessarily be unfavorable. To our knowledge, no other AxD patient whose symptoms vanished for such a long period of time has been reported in the literature. Very recently, a case of adult-onset AxD with remission and relapse was reported, but the remission was only partial and lasted less than 5 years [10]; atypical AxD has been mistaken for remitting–relapsing multiple sclerosis [1]. Because the cervicomedullary atrophy continues to progress in our patient (Fig. 1B), she might still develop an adult form of the disease in the future."}

{"project":"2_test","denotations":[{"id":"22198646-19084454-75888811","span":{"begin":223,"end":224},"obj":"19084454"},{"id":"22198646-20562394-75888812","span":{"begin":684,"end":686},"obj":"20562394"}],"text":"It is noteworthy that the bulbar symptom of this patient regressed spontaneously. She is now 25 years old, and is absolutely free of neurological symptoms, except for short stature with scoliosis, presumably a sign of AxD [9]. This case suggests that the symptoms of AxD can be self-remitting, unlike those of other neurodegenerative disorders, and that the prognosis might not necessarily be unfavorable. To our knowledge, no other AxD patient whose symptoms vanished for such a long period of time has been reported in the literature. Very recently, a case of adult-onset AxD with remission and relapse was reported, but the remission was only partial and lasted less than 5 years [10]; atypical AxD has been mistaken for remitting–relapsing multiple sclerosis [1]. Because the cervicomedullary atrophy continues to progress in our patient (Fig. 1B), she might still develop an adult form of the disease in the future."}