PMC:3396637 / 4239-5546
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3396637","sourcedb":"PMC","sourceid":"3396637","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3396637","text":"Different subfamilies of TEs have seemingly diverse influences on genes and genomes by changing sequence length to variable extents. Specifically, due to the distinction between “copy-and-paste” of retrotransposons and “cut-and-paste” mostly used by DNA transposons, the former should be a primary player in the event of genome size increase.2 Introns are considered as the major “warehouse” of TEs11,13 and certain families of TEs are observed to correlate with functional genes, such as between mammalian interspersed repeats (MIRs) and immune genes.13 Exploiting the relationship between sequence composition and polymorphism, we noticed that minimal introns (introns in a minimal size range) have unique features distinct from larger introns and demonstrated how these smaller introns escape from TE-driven insertions and also largely free from SS-driven intron expansion.14–16 As many vertebrate genomes have now been sequenced, we are able to address more questions on TE- and SS-driven intron expansions in different vertebrate lineages. In particular, we would like to understand how intron expansion relates to gene functions among the three subgroups of mammals—primates, large mammals, and rodents—and what are the roles of mutation and natural selection played in the course of genome evolution.","tracks":[{"project":"2_test","denotations":[{"id":"22807622-12188048-29768488","span":{"begin":342,"end":343},"obj":"12188048"},{"id":"22807622-20525173-29768489","span":{"begin":398,"end":400},"obj":"20525173"},{"id":"22807622-17181857-29768490","span":{"begin":401,"end":403},"obj":"17181857"},{"id":"22807622-17181857-29768491","span":{"begin":552,"end":554},"obj":"17181857"},{"id":"22807622-12176926-29768492","span":{"begin":876,"end":878},"obj":"12176926"},{"id":"22807622-20419085-29768492","span":{"begin":876,"end":878},"obj":"20419085"},{"id":"22807622-21437290-29768492","span":{"begin":876,"end":878},"obj":"21437290"}],"attributes":[{"subj":"22807622-12188048-29768488","pred":"source","obj":"2_test"},{"subj":"22807622-20525173-29768489","pred":"source","obj":"2_test"},{"subj":"22807622-17181857-29768490","pred":"source","obj":"2_test"},{"subj":"22807622-17181857-29768491","pred":"source","obj":"2_test"},{"subj":"22807622-12176926-29768492","pred":"source","obj":"2_test"},{"subj":"22807622-20419085-29768492","pred":"source","obj":"2_test"},{"subj":"22807622-21437290-29768492","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"22807622-12188048-29768488","span":{"begin":342,"end":344},"obj":"12188048"},{"id":"22807622-20525173-29768489","span":{"begin":398,"end":400},"obj":"20525173"},{"id":"22807622-17181857-29768490","span":{"begin":401,"end":404},"obj":"17181857"},{"id":"22807622-17181857-29768491","span":{"begin":552,"end":555},"obj":"17181857"},{"id":"22807622-12176926-29768492","span":{"begin":876,"end":878},"obj":"12176926"},{"id":"22807622-20419085-29768492","span":{"begin":876,"end":878},"obj":"20419085"},{"id":"22807622-21437290-29768492","span":{"begin":876,"end":878},"obj":"21437290"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"22807622-12188048-29768488","pred":"source","obj":"MyTest"},{"subj":"22807622-20525173-29768489","pred":"source","obj":"MyTest"},{"subj":"22807622-17181857-29768490","pred":"source","obj":"MyTest"},{"subj":"22807622-17181857-29768491","pred":"source","obj":"MyTest"},{"subj":"22807622-12176926-29768492","pred":"source","obj":"MyTest"},{"subj":"22807622-20419085-29768492","pred":"source","obj":"MyTest"},{"subj":"22807622-21437290-29768492","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#a093ec","default":true},{"id":"MyTest","color":"#9fec93"}]}]}}