PMC:3359311 / 653-1502 JSONTXT

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T369","span":{"begin":104,"end":109},"obj":"P01584"},{"id":"T370","span":{"begin":358,"end":363},"obj":"P01584"},{"id":"T371","span":{"begin":528,"end":533},"obj":"P01584"},{"id":"T372","span":{"begin":596,"end":601},"obj":"P01584"},{"id":"T373","span":{"begin":795,"end":800},"obj":"P01584"},{"id":"T374","span":{"begin":804,"end":808},"obj":"P10145"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Results\nBronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T49","span":{"begin":54,"end":61},"obj":"Gene_expression"},{"id":"T50","span":{"begin":93,"end":103},"obj":"Positive_regulation"},{"id":"T51","span":{"begin":104,"end":109},"obj":"Protein"},{"id":"T52","span":{"begin":332,"end":340},"obj":"Gene_expression"},{"id":"T53","span":{"begin":358,"end":363},"obj":"Protein"},{"id":"T54","span":{"begin":408,"end":412},"obj":"Positive_regulation"},{"id":"T55","span":{"begin":528,"end":533},"obj":"Protein"},{"id":"T56","span":{"begin":534,"end":544},"obj":"Gene_expression"},{"id":"T57","span":{"begin":550,"end":560},"obj":"Positive_regulation"},{"id":"T58","span":{"begin":596,"end":601},"obj":"Protein"},{"id":"T59","span":{"begin":789,"end":794},"obj":"Regulation"},{"id":"T60","span":{"begin":795,"end":800},"obj":"Protein"},{"id":"T61","span":{"begin":809,"end":819},"obj":"Gene_expression"},{"id":"T62","span":{"begin":820,"end":834},"obj":"Positive_regulation"}],"relations":[{"id":"R30","pred":"themeOf","subj":"T49","obj":"T50"},{"id":"R31","pred":"themeOf","subj":"T51","obj":"T49"},{"id":"R32","pred":"themeOf","subj":"T52","obj":"T54"},{"id":"R33","pred":"themeOf","subj":"T53","obj":"T52"},{"id":"R34","pred":"themeOf","subj":"T55","obj":"T56"},{"id":"R35","pred":"themeOf","subj":"T56","obj":"T57"},{"id":"R36","pred":"themeOf","subj":"T60","obj":"T61"},{"id":"R37","pred":"themeOf","subj":"T61","obj":"T62"},{"id":"R38","pred":"themeOf","subj":"T62","obj":"T59"}],"attributes":[{"id":"M6","pred":"Negation","subj":"T49","obj":"true"},{"id":"M7","pred":"Negation","subj":"T59","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Results\nBronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa."}

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{"project":"GO-CC","denotations":[{"id":"T689","span":{"begin":29,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T690","span":{"begin":136,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T691","span":{"begin":276,"end":281},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T692","span":{"begin":761,"end":766},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Results\nBronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa."}

{"project":"GO-MF","denotations":[{"id":"T696","span":{"begin":804,"end":808},"obj":"http://purl.obolibrary.org/obo/GO_0005153"}],"text":"Results\nBronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa."}

{"project":"GO-BP","denotations":[{"id":"T686","span":{"begin":804,"end":819},"obj":"http://purl.obolibrary.org/obo/GO_0032677"},{"id":"T687","span":{"begin":804,"end":819},"obj":"http://purl.obolibrary.org/obo/GO_0032637"}],"text":"Results\nBronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa."}

{"project":"UBERON-AE","denotations":[{"id":"T36","span":{"begin":258,"end":263},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"Results\nBronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa."}

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