PMC:3359311 / 17086-17809 JSONTXT

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    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T14806","span":{"begin":90,"end":95},"obj":"P01584"},{"id":"T14807","span":{"begin":287,"end":292},"obj":"P01584"},{"id":"T14808","span":{"begin":301,"end":305},"obj":"P10145"},{"id":"T14809","span":{"begin":505,"end":510},"obj":"P01584"},{"id":"T14810","span":{"begin":646,"end":651},"obj":"P01584"},{"id":"T14811","span":{"begin":667,"end":671},"obj":"P10145"},{"id":"T14812","span":{"begin":687,"end":691},"obj":"P05412"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages. Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours. THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).\n\n"}

    bionlp-st-ge-2016-reference

    {"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T14661","span":{"begin":81,"end":89},"obj":"Positive_regulation"},{"id":"T14662","span":{"begin":90,"end":95},"obj":"Protein"},{"id":"T14663","span":{"begin":96,"end":106},"obj":"Gene_expression"},{"id":"T14664","span":{"begin":287,"end":292},"obj":"Protein"},{"id":"T14665","span":{"begin":306,"end":316},"obj":"Gene_expression"},{"id":"T14666","span":{"begin":505,"end":510},"obj":"Protein"},{"id":"T14667","span":{"begin":511,"end":521},"obj":"Gene_expression"},{"id":"T14668","span":{"begin":646,"end":651},"obj":"Protein"},{"id":"T14669","span":{"begin":652,"end":661},"obj":"Localization"}],"relations":[{"id":"R13025","pred":"themeOf","subj":"T14662","obj":"T14663"},{"id":"R13026","pred":"themeOf","subj":"T14663","obj":"T14661"},{"id":"R13027","pred":"themeOf","subj":"T14664","obj":"T14665"},{"id":"R13028","pred":"themeOf","subj":"T14666","obj":"T14667"},{"id":"R13029","pred":"themeOf","subj":"T14668","obj":"T14669"}],"attributes":[{"id":"M207","pred":"Speculation","subj":"T14669","obj":"true"},{"id":"M204","pred":"Negation","subj":"T14661","obj":"true"},{"id":"M205","pred":"Speculation","subj":"T14665","obj":"true"},{"id":"M206","pred":"Speculation","subj":"T14667","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages. Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours. THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).\n\n"}

    bionlp-st-ge-2016-reference-tees

    {"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T15001","span":{"begin":58,"end":62},"obj":"Protein"},{"id":"T15002","span":{"begin":90,"end":95},"obj":"Protein"},{"id":"T15003","span":{"begin":44,"end":54},"obj":"Negative_regulation"},{"id":"T15004","span":{"begin":96,"end":106},"obj":"Gene_expression"},{"id":"T15005","span":{"begin":81,"end":89},"obj":"Positive_regulation"},{"id":"T15006","span":{"begin":267,"end":271},"obj":"Protein"},{"id":"T15007","span":{"begin":447,"end":457},"obj":"Protein"},{"id":"T15008","span":{"begin":505,"end":510},"obj":"Protein"},{"id":"T15009","span":{"begin":511,"end":521},"obj":"Gene_expression"},{"id":"T15010","span":{"begin":620,"end":624},"obj":"Protein"},{"id":"T15011","span":{"begin":684,"end":686},"obj":"Protein"},{"id":"T15012","span":{"begin":687,"end":691},"obj":"Protein"}],"relations":[{"id":"R13332","pred":"themeOf","subj":"T15001","obj":"T15003"},{"id":"R13333","pred":"themeOf","subj":"T15002","obj":"T15004"},{"id":"R13334","pred":"causeOf","subj":"T15003","obj":"T15005"},{"id":"R13335","pred":"themeOf","subj":"T15004","obj":"T15005"},{"id":"R13336","pred":"themeOf","subj":"T15008","obj":"T15009"}],"text":"10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages. Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours. THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).\n\n"}

    events-check-again

    {"project":"events-check-again","denotations":[{"id":"T14992","span":{"begin":81,"end":89},"obj":"Positive_regulation"},{"id":"T14993","span":{"begin":90,"end":95},"obj":"Protein"},{"id":"T14994","span":{"begin":96,"end":106},"obj":"Gene_expression"},{"id":"T14995","span":{"begin":287,"end":292},"obj":"Protein"},{"id":"T14996","span":{"begin":306,"end":316},"obj":"Gene_expression"},{"id":"T14997","span":{"begin":505,"end":510},"obj":"Protein"},{"id":"T14998","span":{"begin":511,"end":521},"obj":"Gene_expression"},{"id":"T14999","span":{"begin":646,"end":651},"obj":"Protein"},{"id":"T15000","span":{"begin":652,"end":661},"obj":"Localization"}],"relations":[{"id":"R13327","pred":"themeOf","subj":"T14993","obj":"T14994"},{"id":"R13328","pred":"themeOf","subj":"T14994","obj":"T14992"},{"id":"R13329","pred":"themeOf","subj":"T14995","obj":"T14996"},{"id":"R13330","pred":"themeOf","subj":"T14997","obj":"T14998"},{"id":"R13331","pred":"themeOf","subj":"T14999","obj":"T15000"}],"attributes":[{"id":"M216","pred":"Negation","subj":"T14992","obj":"true"},{"id":"M218","pred":"Speculation","subj":"T14998","obj":"true"},{"id":"M217","pred":"Speculation","subj":"T14996","obj":"true"},{"id":"M219","pred":"Speculation","subj":"T15000","obj":"true"}],"text":"10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages. Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours. THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).\n\n"}

    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T14971","span":{"begin":550,"end":555},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages. Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours. THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).\n\n"}

    GO-MF

    {"project":"GO-MF","denotations":[{"id":"T14972","span":{"begin":301,"end":305},"obj":"http://purl.obolibrary.org/obo/GO_0005153"},{"id":"T14973","span":{"begin":667,"end":671},"obj":"http://purl.obolibrary.org/obo/GO_0005153"}],"text":"10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages. Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours. THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).\n\n"}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T14967","span":{"begin":301,"end":316},"obj":"http://purl.obolibrary.org/obo/GO_0032677"},{"id":"T14968","span":{"begin":301,"end":316},"obj":"http://purl.obolibrary.org/obo/GO_0032637"},{"id":"T14969","span":{"begin":384,"end":415},"obj":"http://purl.obolibrary.org/obo/GO_0030225"},{"id":"T14970","span":{"begin":652,"end":661},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages. Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours. THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).\n\n"}

    bionlp-st-ge-2016-spacy-parsed

    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Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.\nPBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). 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