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PMC:3359311 / 16297-17810 JSONTXT

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bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T5633 46-51 P01584 denotes IL-1β
T5634 256-261 P01584 denotes IL-1β
T5635 469-474 P01584 denotes IL-1β
T5636 478-482 P10145 denotes IL-8
T5637 553-558 P01584 denotes IL-1β
T5638 681-685 P10145 denotes IL-8
T14806 879-884 P01584 denotes IL-1β
T14807 1076-1081 P01584 denotes IL-1β
T14808 1090-1094 P10145 denotes IL-8
T14809 1294-1299 P01584 denotes IL-1β
T14810 1435-1440 P01584 denotes IL-1β
T14811 1456-1460 P10145 denotes IL-8
T14812 1476-1480 P05412 denotes AP-1

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T5486 37-45 Positive_regulation denotes increase true
T5487 46-51 Protein denotes IL-1β
T5488 52-62 Gene_expression denotes production
T5489 249-255 Regulation denotes alters true
T5490 256-261 Protein denotes IL-1β
T5491 262-272 Gene_expression denotes production
T5492 463-468 Regulation denotes alter true
T5493 469-474 Protein denotes IL-1β
T5494 483-493 Gene_expression denotes production
T5495 553-558 Protein denotes IL-1β
T5496 559-569 Gene_expression denotes production
T14661 870-878 Positive_regulation denotes increase true
T14662 879-884 Protein denotes IL-1β
T14663 885-895 Gene_expression denotes production
T14664 1076-1081 Protein denotes IL-1β
T14665 1095-1105 Gene_expression denotes production true
T14666 1294-1299 Protein denotes IL-1β
T14667 1300-1310 Gene_expression denotes production true
T14668 1435-1440 Protein denotes IL-1β
T14669 1441-1450 Localization denotes secretion true
R4746 T5487 T5488 themeOf IL-1β,production
R4747 T5488 T5486 themeOf production,increase
R4748 T5490 T5491 themeOf IL-1β,production
R4749 T5491 T5489 themeOf production,alters
R4750 T5493 T5494 themeOf IL-1β,production
R4751 T5494 T5492 themeOf production,alter
R4752 T5495 T5496 themeOf IL-1β,production
R13025 T14662 T14663 themeOf IL-1β,production
R13026 T14663 T14661 themeOf production,increase
R13027 T14664 T14665 themeOf IL-1β,production
R13028 T14666 T14667 themeOf IL-1β,production
R13029 T14668 T14669 themeOf IL-1β,secretion

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T5823 14-18 Protein denotes CFTR
T5824 46-51 Protein denotes IL-1β
T5825 0-10 Negative_regulation denotes Disruption
T5826 52-62 Gene_expression denotes production
T5827 37-45 Positive_regulation denotes increase
T5828 175-193 Protein denotes NLRP3 inflammasome
T5829 232-236 Protein denotes CFTR
T5830 256-261 Protein denotes IL-1β
T5831 356-360 Protein denotes CFTR
T5832 237-248 Positive_regulation denotes dysfunction
T5833 262-272 Gene_expression denotes production
T5834 249-255 Positive_regulation denotes alters
T5835 469-474 Protein denotes IL-1β
T5836 478-482 Protein denotes IL-8
T5837 483-493 Gene_expression denotes production
T5838 483-493 Gene_expression denotes production
T5839 463-468 Regulation denotes alter
T5840 463-468 Regulation denotes alter
T5841 553-558 Protein denotes IL-1β
T5842 657-667 Protein denotes CFTRinh172
T5843 669-672 Protein denotes Fig
T5844 559-569 Gene_expression denotes production
T5845 681-685 Protein denotes IL-8
T5846 687-694 Protein denotes Fig. 8e
T5847 700-705 Protein denotes NF-κB
T5848 716-723 Protein denotes Fig. 8f
T15001 847-851 Protein denotes CFTR
T15002 879-884 Protein denotes IL-1β
T15003 833-843 Negative_regulation denotes Disruption
T15004 885-895 Gene_expression denotes production
T15005 870-878 Positive_regulation denotes increase
T15006 1056-1060 Protein denotes PAO1
T15007 1236-1246 Protein denotes CFTRinh172
T15008 1294-1299 Protein denotes IL-1β
T15009 1300-1310 Gene_expression denotes production
T15010 1409-1413 Protein denotes PAO1
T15011 1473-1475 Protein denotes κB
T15012 1476-1480 Protein denotes AP-1
R5050 T5835 T5837 themeOf IL-1β,production
R5051 T5836 T5838 themeOf IL-8,production
R5042 T5823 T5825 themeOf CFTR,Disruption
R5043 T5824 T5826 themeOf IL-1β,production
R5044 T5825 T5827 causeOf Disruption,increase
R5045 T5826 T5827 themeOf production,increase
R5046 T5829 T5832 themeOf CFTR,dysfunction
R5047 T5830 T5833 themeOf IL-1β,production
R5048 T5832 T5834 causeOf dysfunction,alters
R5049 T5833 T5834 themeOf production,alters
R5052 T5837 T5839 themeOf production,alter
R5053 T5838 T5840 themeOf production,alter
R5054 T5841 T5844 themeOf IL-1β,production
R13332 T15001 T15003 themeOf CFTR,Disruption
R13333 T15002 T15004 themeOf IL-1β,production
R13334 T15003 T15005 causeOf Disruption,increase
R13335 T15004 T15005 themeOf production,increase
R13336 T15008 T15009 themeOf IL-1β,production

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T5812 37-45 Positive_regulation denotes increase true
T5813 46-51 Protein denotes IL-1β
T5814 52-62 Gene_expression denotes production
T5815 249-255 Regulation denotes alters true
T5816 256-261 Protein denotes IL-1β
T5817 262-272 Gene_expression denotes production
T5818 463-468 Regulation denotes alter true
T5819 469-474 Protein denotes IL-1β
T5820 483-493 Gene_expression denotes production
T5821 553-558 Protein denotes IL-1β
T5822 559-569 Gene_expression denotes production
T14992 870-878 Positive_regulation denotes increase true
T14993 879-884 Protein denotes IL-1β
T14994 885-895 Gene_expression denotes production
T14995 1076-1081 Protein denotes IL-1β
T14996 1095-1105 Gene_expression denotes production true
T14997 1294-1299 Protein denotes IL-1β
T14998 1300-1310 Gene_expression denotes production true
T14999 1435-1440 Protein denotes IL-1β
T15000 1441-1450 Localization denotes secretion true
R5035 T5813 T5814 themeOf IL-1β,production
R5036 T5814 T5812 themeOf production,increase
R5037 T5816 T5817 themeOf IL-1β,production
R5038 T5817 T5815 themeOf production,alters
R5039 T5819 T5820 themeOf IL-1β,production
R5040 T5820 T5818 themeOf production,alter
R5041 T5821 T5822 themeOf IL-1β,production
R13327 T14993 T14994 themeOf IL-1β,production
R13328 T14994 T14992 themeOf production,increase
R13329 T14995 T14996 themeOf IL-1β,production
R13330 T14997 T14998 themeOf IL-1β,production
R13331 T14999 T15000 themeOf IL-1β,secretion

GO-CC

Id Subject Object Predicate Lexical cue
T5786 82-87 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5787 280-285 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5788 638-643 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5789 782-787 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14971 1339-1344 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

GO-MF

Id Subject Object Predicate Lexical cue
T5784 478-482 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T5785 681-685 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T14972 1090-1094 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T14973 1456-1460 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8

GO-BP

Id Subject Object Predicate Lexical cue
T5782 478-493 http://purl.obolibrary.org/obo/GO_0032677 denotes IL-8 production
T5783 478-493 http://purl.obolibrary.org/obo/GO_0032637 denotes IL-8 production
T14967 1090-1105 http://purl.obolibrary.org/obo/GO_0032677 denotes IL-8 production
T14968 1090-1105 http://purl.obolibrary.org/obo/GO_0032637 denotes IL-8 production
T14969 1173-1204 http://purl.obolibrary.org/obo/GO_0030225 denotes differentiated into macrophages
T14970 1441-1450 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T5639 0-10 NN denotes Disruption
T5640 11-13 IN denotes of
T5641 14-18 NNP denotes CFTR
T5642 19-27 NN denotes activity
T5643 28-32 VBZ denotes does
T5644 33-36 RB denotes not
T5645 37-45 VB denotes increase
T5646 46-51 JJ denotes IL-1β
T5647 52-62 NN denotes production
T5648 63-65 IN denotes in
T5649 66-71 NNP denotes PBMCs
T5650 72-75 CC denotes and
T5651 76-81 NNP denotes THP-1
T5652 82-87 NNS denotes cells
T5653 88-89 DT denotes A
T5654 90-98 JJ denotes previous
T5655 99-104 NN denotes study
T5656 105-108 VBZ denotes has
T5657 109-118 VBN denotes indicated
T5658 119-120 DT denotes a
T5659 121-125 NN denotes role
T5660 126-129 IN denotes for
T5661 130-138 NN denotes chloride
T5662 139-142 NN denotes ion
T5663 143-156 NN denotes concentration
T5664 157-159 IN denotes in
T5665 160-171 NN denotes suppression
T5666 172-174 IN denotes of
T5667 175-180 CD denotes NLRP3
T5668 181-193 JJ denotes inflammasome
T5669 194-204 NN denotes activation
T5670 205-206 NNP denotes [
T5671 206-208 CD denotes 34
T5672 208-209 NNP denotes ]
T5673 209-210 . denotes .
T5674 211-213 TO denotes To
T5675 214-223 VB denotes determine
T5676 224-231 IN denotes whether
T5677 232-236 NNP denotes CFTR
T5678 237-248 NN denotes dysfunction
T5679 249-255 VBZ denotes alters
T5680 256-261 JJ denotes IL-1β
T5681 262-272 NN denotes production
T5682 272-273 , denotes ,
T5683 274-279 CD denotes THP-1
T5684 280-285 NNS denotes cells
T5685 286-289 CC denotes and
T5686 290-295 NNS denotes PBMCs
T5687 296-300 IN denotes from
T5688 301-303 NNP denotes CF
T5689 304-312 NNS denotes patients
T5690 313-316 CC denotes and
T5691 317-324 JJ denotes healthy
T5692 325-333 NNS denotes controls
T5693 334-338 VBD denotes were
T5694 339-346 VBN denotes treated
T5695 347-351 IN denotes with
T5696 352-355 DT denotes the
T5697 356-360 NNP denotes CFTR
T5698 361-370 NN denotes inhibitor
T5699 370-371 , denotes ,
T5700 372-382 NNP denotes CFTRinh172
T5701 382-383 , denotes ,
T5702 384-389 RB denotes prior
T5703 390-392 TO denotes to
T5704 393-403 NN denotes simulation
T5705 404-408 IN denotes with
T5706 409-413 JJ denotes live
T5707 414-416 NNP denotes P.
T5708 417-427 NN denotes aeruginosa
T5709 427-428 . denotes .
T5710 429-438 NNP denotes Treatment
T5711 439-443 IN denotes with
T5712 444-454 NNP denotes CFTRinh172
T5713 455-458 VBD denotes did
T5714 459-462 RB denotes not
T5715 463-468 VB denotes alter
T5716 469-474 JJ denotes IL-1β
T5717 475-477 CC denotes or
T5718 478-482 JJ denotes IL-8
T5719 483-493 NN denotes production
T5720 494-496 IN denotes in
T5721 497-504 NN denotes control
T5722 505-513 NNS denotes subjects
T5723 514-516 CC denotes or
T5724 517-519 NN denotes CF
T5725 520-528 NNS denotes patients
T5726 529-530 -LRB- denotes (
T5727 530-534 NNP denotes Fig.
T5728 535-537 CD denotes 8a
T5729 538-539 NN denotes b
T5730 539-540 -RRB- denotes )
T5731 540-541 . denotes .
T5732 542-551 RB denotes Similarly
T5733 551-552 , denotes ,
T5734 553-558 JJ denotes IL-1β
T5735 559-569 NN denotes production
T5736 570-573 VBD denotes was
T5737 574-577 RB denotes not
T5738 578-587 JJ denotes different
T5739 588-590 IN denotes in
T5740 591-607 JJ denotes monocyte-derived
T5741 608-619 NNS denotes macrophages
T5742 620-622 CC denotes or
T5743 623-628 CD denotes THP-1
T5744 629-637 NN denotes reporter
T5745 638-643 NNS denotes cells
T5746 644-651 VBN denotes treated
T5747 652-656 IN denotes with
T5748 657-667 NNP denotes CFTRinh172
T5749 668-669 -LRB- denotes (
T5750 669-673 NNP denotes Fig.
T5751 674-676 CD denotes 8c
T5752 677-678 LS denotes d
T5753 678-679 -RRB- denotes )
T5754 679-680 . denotes .
T5755 681-685 NN denotes IL-8
T5756 686-687 -LRB- denotes (
T5757 687-691 NNP denotes Fig.
T5758 692-694 CD denotes 8e
T5759 694-695 -RRB- denotes )
T5760 696-699 CC denotes and
T5761 700-705 JJ denotes NF-κB
T5762 706-714 NN denotes activity
T5763 715-716 -LRB- denotes (
T5764 716-720 NNP denotes Fig.
T5765 721-723 CD denotes 8f
T5766 723-724 -RRB- denotes )
T5767 725-729 VBD denotes were
T5768 730-734 RB denotes also
T5769 735-744 JJ denotes unchanged
T5770 745-747 IN denotes in
T5771 748-766 JJ denotes CFTRinh172-treated
T5772 767-772 CD denotes THP-1
T5773 773-781 NN denotes reporter
T5774 782-787 NNS denotes cells
T5775 787-788 . denotes .
T14813 833-843 NN denotes Disruption
T14814 844-846 IN denotes of
T14815 847-851 NNP denotes CFTR
T14816 852-860 NN denotes activity
T14817 861-865 VBZ denotes does
T14818 866-869 RB denotes not
T14819 870-878 VB denotes increase
T14820 879-884 JJ denotes IL-1β
T14821 885-895 NN denotes production
T14822 896-898 IN denotes in
T14823 899-904 NNP denotes PBMCs
T14824 905-907 CC denotes or
T14825 908-919 NNS denotes macrophages
T14826 919-920 . denotes .
T14827 921-926 NNS denotes PBMCs
T14828 927-931 IN denotes from
T14829 932-934 NNP denotes CF
T14830 935-943 NNS denotes patients
T14831 944-945 -LRB- denotes (
T14832 945-946 FW denotes n
T14833 947-948 SYM denotes =
T14834 949-951 CD denotes 15
T14835 951-952 -RRB- denotes )
T14836 953-956 CC denotes and
T14837 957-965 NNS denotes controls
T14838 966-967 -LRB- denotes (
T14839 967-968 FW denotes n
T14840 969-970 SYM denotes =
T14841 971-973 CD denotes 13
T14842 973-974 -RRB- denotes )
T14843 975-979 VBD denotes were
T14844 980-987 VBN denotes treated
T14845 988-992 IN denotes with
T14846 993-1003 NNP denotes CFTRinh172
T14847 1004-1005 -LRB- denotes (
T14848 1005-1007 CD denotes 10
T14849 1008-1010 NNP denotes µM
T14850 1010-1011 -RRB- denotes )
T14851 1012-1015 IN denotes for
T14852 1016-1018 CD denotes 18
T14853 1019-1024 NNS denotes hours
T14854 1025-1030 RB denotes prior
T14855 1031-1033 TO denotes to
T14856 1034-1045 NN denotes stimulation
T14857 1046-1050 IN denotes with
T14858 1051-1055 JJ denotes live
T14859 1056-1060 NNP denotes PAO1
T14860 1061-1062 -LRB- denotes (
T14861 1062-1065 NNP denotes MOI
T14862 1066-1067 SYM denotes =
T14863 1068-1069 LS denotes 1
T14864 1069-1070 -RRB- denotes )
T14865 1070-1071 . denotes .
T14866 1072-1073 -LRB- denotes (
T14867 1073-1074 NN denotes A
T14868 1074-1075 -RRB- denotes )
T14869 1076-1081 NN denotes IL-1β
T14870 1082-1085 CC denotes and
T14871 1086-1087 -LRB- denotes (
T14872 1087-1088 NNP denotes B
T14873 1088-1089 -RRB- denotes )
T14874 1090-1094 JJ denotes IL-8
T14875 1095-1105 NN denotes production
T14876 1106-1109 VBD denotes was
T14877 1110-1118 VBN denotes measured
T14878 1119-1121 IN denotes at
T14879 1122-1124 CD denotes 24
T14880 1125-1130 NNS denotes hours
T14881 1130-1131 . denotes .
T14882 1132-1133 -LRB- denotes (
T14883 1133-1134 $ denotes C
T14884 1134-1135 -RRB- denotes )
T14885 1136-1145 NNPS denotes Monocytes
T14886 1146-1150 IN denotes from
T14887 1151-1159 NNS denotes controls
T14888 1160-1161 -LRB- denotes (
T14889 1161-1162 FW denotes n
T14890 1163-1164 SYM denotes =
T14891 1165-1166 LS denotes 3
T14892 1166-1167 -RRB- denotes )
T14893 1168-1172 VBD denotes were
T14894 1173-1187 VBN denotes differentiated
T14895 1188-1192 IN denotes into
T14896 1193-1204 NNS denotes macrophages
T14897 1204-1205 . denotes .
T14898 1206-1217 NNS denotes Macrophages
T14899 1218-1222 VBD denotes were
T14900 1223-1230 VBN denotes treated
T14901 1231-1235 IN denotes with
T14902 1236-1246 NNP denotes CFTRinh172
T14903 1246-1247 , denotes ,
T14904 1248-1258 VBD denotes stimulated
T14905 1259-1261 IN denotes as
T14906 1262-1265 IN denotes per
T14907 1266-1275 NNS denotes monocytes
T14908 1275-1276 , denotes ,
T14909 1277-1280 CC denotes and
T14910 1281-1289 VBN denotes measured
T14911 1290-1293 IN denotes for
T14912 1294-1299 JJ denotes IL-1β
T14913 1300-1310 NN denotes production
T14914 1311-1313 IN denotes at
T14915 1314-1316 CD denotes 24
T14916 1317-1322 NNS denotes hours
T14917 1322-1323 . denotes .
T14918 1324-1329 CD denotes THP-1
T14919 1330-1338 NN denotes reporter
T14920 1339-1344 NNS denotes cells
T14921 1345-1349 VBD denotes were
T14922 1350-1357 VBN denotes treated
T14923 1358-1362 IN denotes with
T14924 1363-1373 NNP denotes CFTRinh172
T14925 1374-1376 CD denotes 24
T14926 1377-1382 NNS denotes hours
T14927 1383-1388 RB denotes prior
T14928 1389-1391 TO denotes to
T14929 1392-1403 NN denotes stimulation
T14930 1404-1408 IN denotes with
T14931 1409-1413 NNP denotes PAO1
T14932 1414-1417 CC denotes and
T14933 1418-1426 VBN denotes measured
T14934 1427-1430 IN denotes for
T14935 1431-1432 -LRB- denotes (
T14936 1432-1433 NNP denotes D
T14937 1433-1434 -RRB- denotes )
T14938 1435-1440 JJ denotes IL-1β
T14939 1441-1450 NN denotes secretion
T14940 1450-1451 , denotes ,
T14941 1452-1453 -LRB- denotes (
T14942 1453-1454 NNP denotes E
T14943 1454-1455 -RRB- denotes )
T14944 1456-1460 NN denotes IL-8
T14945 1460-1461 , denotes ,
T14946 1462-1465 CC denotes and
T14947 1466-1467 -LRB- denotes (
T14948 1467-1468 NN denotes F
T14949 1468-1469 -RRB- denotes )
T14950 1470-1475 NN denotes NF-κB
T14951 1475-1476 NN denotes /
T14952 1476-1480 NN denotes AP-1
T14953 1481-1489 NN denotes activity
T14954 1490-1492 IN denotes at
T14955 1493-1495 CD denotes 24
T14956 1496-1501 NNS denotes hours
T14957 1502-1503 -LRB- denotes (
T14958 1503-1504 FW denotes n
T14959 1505-1506 SYM denotes =
T14960 1507-1508 LS denotes 4
T14961 1508-1509 -RRB- denotes )
T14962 1509-1510 . denotes .
R4884 T5639 T5645 nsubj Disruption,increase
R4885 T5640 T5639 prep of,Disruption
R4886 T5641 T5642 amod CFTR,activity
R4887 T5642 T5640 pobj activity,of
R4888 T5643 T5645 aux does,increase
R4889 T5644 T5645 neg not,increase
R4890 T5645 T5645 ROOT increase,increase
R4891 T5646 T5647 amod IL-1β,production
R4892 T5647 T5645 dobj production,increase
R4893 T5648 T5647 prep in,production
R4894 T5649 T5648 pobj PBMCs,in
R4895 T5650 T5649 cc and,PBMCs
R4896 T5651 T5649 conj THP-1,PBMCs
R4897 T5652 T5647 conj cells,production
R4898 T5653 T5655 det A,study
R4899 T5654 T5655 amod previous,study
R4900 T5655 T5657 nsubj study,indicated
R4901 T5656 T5657 aux has,indicated
R4902 T5657 T5645 conj indicated,increase
R4903 T5658 T5659 det a,role
R4904 T5659 T5657 dobj role,indicated
R4905 T5660 T5659 prep for,role
R4906 T5661 T5663 compound chloride,concentration
R4907 T5662 T5663 compound ion,concentration
R4908 T5663 T5660 pobj concentration,for
R4909 T5664 T5663 prep in,concentration
R4910 T5665 T5664 pobj suppression,in
R4911 T5666 T5665 prep of,suppression
R4912 T5667 T5669 nmod NLRP3,activation
R4913 T5668 T5669 amod inflammasome,activation
R4914 T5669 T5666 pobj activation,of
R4915 T5670 T5664 pobj [,in
R4916 T5671 T5672 nummod 34,]
R4917 T5672 T5670 appos ],[
R4918 T5673 T5657 punct .,indicated
R4919 T5674 T5675 aux To,determine
R4920 T5675 T5694 advcl determine,treated
R4921 T5676 T5679 mark whether,alters
R4922 T5677 T5678 amod CFTR,dysfunction
R4923 T5678 T5679 nsubj dysfunction,alters
R4924 T5679 T5675 ccomp alters,determine
R4925 T5680 T5681 amod IL-1β,production
R4926 T5681 T5694 nsubjpass production,treated
R4927 T5682 T5681 punct ",",production
R4928 T5683 T5684 nummod THP-1,cells
R4929 T5684 T5681 conj cells,production
R4930 T5685 T5684 cc and,cells
R4931 T5686 T5684 conj PBMCs,cells
R4932 T5687 T5681 prep from,production
R4933 T5688 T5689 compound CF,patients
R4934 T5689 T5687 pobj patients,from
R4935 T5690 T5689 cc and,patients
R4936 T5691 T5692 amod healthy,controls
R4937 T5692 T5689 conj controls,patients
R4938 T5693 T5694 auxpass were,treated
R4939 T5694 T5694 ROOT treated,treated
R4940 T5695 T5694 prep with,treated
R4941 T5696 T5698 det the,inhibitor
R4942 T5697 T5698 compound CFTR,inhibitor
R4943 T5698 T5695 pobj inhibitor,with
R4944 T5699 T5698 punct ",",inhibitor
R4945 T5700 T5698 appos CFTRinh172,inhibitor
R4946 T5701 T5698 punct ",",inhibitor
R4947 T5702 T5694 advmod prior,treated
R4948 T5703 T5702 prep to,prior
R4949 T5704 T5703 pobj simulation,to
R4950 T5705 T5694 prep with,treated
R4951 T5706 T5708 amod live,aeruginosa
R4952 T5707 T5708 compound P.,aeruginosa
R4953 T5708 T5705 pobj aeruginosa,with
R4954 T5709 T5694 punct .,treated
R4955 T5710 T5715 nsubj Treatment,alter
R4956 T5711 T5710 prep with,Treatment
R4957 T5712 T5711 pobj CFTRinh172,with
R4958 T5713 T5715 aux did,alter
R4959 T5714 T5715 neg not,alter
R4960 T5715 T5715 ROOT alter,alter
R4961 T5716 T5719 amod IL-1β,production
R4962 T5717 T5716 cc or,IL-1β
R4963 T5718 T5716 conj IL-8,IL-1β
R4964 T5719 T5715 dobj production,alter
R4965 T5720 T5719 prep in,production
R4966 T5721 T5722 compound control,subjects
R4967 T5722 T5720 pobj subjects,in
R4968 T5723 T5722 cc or,subjects
R4969 T5724 T5725 compound CF,patients
R4970 T5725 T5722 conj patients,subjects
R4971 T5726 T5725 punct (,patients
R4972 T5727 T5728 compound Fig.,8a
R4973 T5728 T5725 appos 8a,patients
R4974 T5729 T5725 appos b,patients
R4975 T5730 T5725 punct ),patients
R4976 T5731 T5715 punct .,alter
R4977 T5732 T5736 advmod Similarly,was
R4978 T5733 T5736 punct ",",was
R4979 T5734 T5735 compound IL-1β,production
R4980 T5735 T5736 nsubj production,was
R4981 T5736 T5736 ROOT was,was
R4982 T5737 T5736 neg not,was
R4983 T5738 T5736 acomp different,was
R4984 T5739 T5738 prep in,different
R4985 T5740 T5741 amod monocyte-derived,macrophages
R4986 T5741 T5739 pobj macrophages,in
R4987 T5742 T5741 cc or,macrophages
R4988 T5743 T5745 nummod THP-1,cells
R4989 T5744 T5745 compound reporter,cells
R4990 T5745 T5741 conj cells,macrophages
R4991 T5746 T5741 acl treated,macrophages
R4992 T5747 T5746 prep with,treated
R4993 T5748 T5747 pobj CFTRinh172,with
R4994 T5749 T5748 punct (,CFTRinh172
R4995 T5750 T5748 appos Fig.,CFTRinh172
R4996 T5751 T5750 nummod 8c,Fig.
R4997 T5752 T5746 npadvmod d,treated
R4998 T5753 T5752 punct ),d
R4999 T5754 T5736 punct .,was
R5000 T5755 T5767 nsubj IL-8,were
R5001 T5756 T5757 punct (,Fig.
R5002 T5757 T5755 appos Fig.,IL-8
R5003 T5758 T5757 nummod 8e,Fig.
R5004 T5759 T5757 punct ),Fig.
R5005 T5760 T5755 cc and,IL-8
R5006 T5761 T5762 amod NF-κB,activity
R5007 T5762 T5755 conj activity,IL-8
R5008 T5763 T5755 punct (,IL-8
R5009 T5764 T5755 appos Fig.,IL-8
R5010 T5765 T5764 nummod 8f,Fig.
R5011 T5766 T5755 punct ),IL-8
R5012 T5767 T5767 ROOT were,were
R5013 T5768 T5767 advmod also,were
R5014 T5769 T5767 acomp unchanged,were
R5015 T5770 T5767 prep in,were
R5016 T5771 T5774 amod CFTRinh172-treated,cells
R5017 T5772 T5774 nummod THP-1,cells
R5018 T5773 T5774 compound reporter,cells
R5019 T5774 T5770 pobj cells,in
R5020 T5775 T5767 punct .,were
R13167 T14813 T14819 nsubj Disruption,increase
R13168 T14814 T14813 prep of,Disruption
R13169 T14815 T14816 amod CFTR,activity
R13170 T14816 T14814 pobj activity,of
R13171 T14817 T14819 aux does,increase
R13172 T14818 T14819 neg not,increase
R13173 T14819 T14819 ROOT increase,increase
R13174 T14820 T14821 amod IL-1β,production
R13175 T14821 T14819 dobj production,increase
R13176 T14822 T14821 prep in,production
R13177 T14823 T14822 pobj PBMCs,in
R13178 T14824 T14823 cc or,PBMCs
R13179 T14825 T14823 conj macrophages,PBMCs
R13180 T14826 T14819 punct .,increase
R13181 T14827 T14844 nsubjpass PBMCs,treated
R13182 T14828 T14827 prep from,PBMCs
R13183 T14829 T14830 compound CF,patients
R13184 T14830 T14828 pobj patients,from
R13185 T14831 T14830 punct (,patients
R13186 T14832 T14834 nmod n,15
R13187 T14833 T14834 punct =,15
R13188 T14834 T14827 appos 15,PBMCs
R13189 T14835 T14827 punct ),PBMCs
R13190 T14836 T14827 cc and,PBMCs
R13191 T14837 T14827 conj controls,PBMCs
R13192 T14838 T14837 punct (,controls
R13193 T14839 T14841 advmod n,13
R13194 T14840 T14841 punct =,13
R13195 T14841 T14837 appos 13,controls
R13196 T14842 T14837 punct ),controls
R13197 T14843 T14844 auxpass were,treated
R13198 T14844 T14844 ROOT treated,treated
R13199 T14845 T14844 prep with,treated
R13200 T14846 T14845 pobj CFTRinh172,with
R13201 T14847 T14849 punct (,µM
R13202 T14848 T14849 nummod 10,µM
R13203 T14849 T14846 appos µM,CFTRinh172
R13204 T14850 T14844 punct ),treated
R13205 T14851 T14844 prep for,treated
R13206 T14852 T14853 nummod 18,hours
R13207 T14853 T14851 pobj hours,for
R13208 T14854 T14844 advmod prior,treated
R13209 T14855 T14854 prep to,prior
R13210 T14856 T14855 pobj stimulation,to
R13211 T14857 T14844 prep with,treated
R13212 T14858 T14859 amod live,PAO1
R13213 T14859 T14857 pobj PAO1,with
R13214 T14860 T14861 punct (,MOI
R13215 T14861 T14859 appos MOI,PAO1
R13216 T14862 T14863 punct =,1
R13217 T14863 T14861 nummod 1,MOI
R13218 T14864 T14863 punct ),1
R13219 T14865 T14844 punct .,treated
R13220 T14866 T14869 punct (,IL-1β
R13221 T14867 T14869 nmod A,IL-1β
R13222 T14868 T14867 punct ),A
R13223 T14869 T14877 nsubjpass IL-1β,measured
R13224 T14870 T14869 cc and,IL-1β
R13225 T14871 T14872 punct (,B
R13226 T14872 T14875 nmod B,production
R13227 T14873 T14872 punct ),B
R13228 T14874 T14875 compound IL-8,production
R13229 T14875 T14869 conj production,IL-1β
R13230 T14876 T14877 auxpass was,measured
R13231 T14877 T14877 ROOT measured,measured
R13232 T14878 T14877 prep at,measured
R13233 T14879 T14880 nummod 24,hours
R13234 T14880 T14878 pobj hours,at
R13235 T14881 T14877 punct .,measured
R13236 T14882 T14883 punct (,C
R13237 T14883 T14883 ROOT C,C
R13238 T14884 T14883 punct ),C
R13239 T14885 T14894 nsubjpass Monocytes,differentiated
R13240 T14886 T14885 prep from,Monocytes
R13241 T14887 T14886 pobj controls,from
R13242 T14888 T14887 punct (,controls
R13243 T14889 T14887 appos n,controls
R13244 T14890 T14887 punct =,controls
R13245 T14891 T14894 nsubjpass 3,differentiated
R13246 T14892 T14891 punct ),3
R13247 T14893 T14894 auxpass were,differentiated
R13248 T14894 T14894 ROOT differentiated,differentiated
R13249 T14895 T14894 prep into,differentiated
R13250 T14896 T14895 pobj macrophages,into
R13251 T14897 T14894 punct .,differentiated
R13252 T14898 T14900 nsubjpass Macrophages,treated
R13253 T14899 T14900 auxpass were,treated
R13254 T14900 T14900 ROOT treated,treated
R13255 T14901 T14900 prep with,treated
R13256 T14902 T14901 pobj CFTRinh172,with
R13257 T14903 T14904 punct ",",stimulated
R13258 T14904 T14900 advcl stimulated,treated
R13259 T14905 T14904 prep as,stimulated
R13260 T14906 T14905 prep per,as
R13261 T14907 T14906 pobj monocytes,per
R13262 T14908 T14904 punct ",",stimulated
R13263 T14909 T14904 cc and,stimulated
R13264 T14910 T14904 conj measured,stimulated
R13265 T14911 T14910 prep for,measured
R13266 T14912 T14913 compound IL-1β,production
R13267 T14913 T14911 pobj production,for
R13268 T14914 T14910 prep at,measured
R13269 T14915 T14916 nummod 24,hours
R13270 T14916 T14914 pobj hours,at
R13271 T14917 T14900 punct .,treated
R13272 T14918 T14920 nummod THP-1,cells
R13273 T14919 T14920 compound reporter,cells
R13274 T14920 T14922 nsubjpass cells,treated
R13275 T14921 T14922 auxpass were,treated
R13276 T14922 T14922 ROOT treated,treated
R13277 T14923 T14922 prep with,treated
R13278 T14924 T14923 pobj CFTRinh172,with
R13279 T14925 T14926 nummod 24,hours
R13280 T14926 T14927 npadvmod hours,prior
R13281 T14927 T14922 advmod prior,treated
R13282 T14928 T14927 prep to,prior
R13283 T14929 T14928 pobj stimulation,to
R13284 T14930 T14922 prep with,treated
R13285 T14931 T14930 pobj PAO1,with
R13286 T14932 T14922 cc and,treated
R13287 T14933 T14922 conj measured,treated
R13288 T14934 T14933 prep for,measured
R13289 T14935 T14936 punct (,D
R13290 T14936 T14934 pobj D,for
R13291 T14937 T14933 punct ),measured
R13292 T14938 T14939 amod IL-1β,secretion
R13293 T14939 T14939 ROOT secretion,secretion
R13294 T14940 T14939 punct ",",secretion
R13295 T14941 T14944 punct (,IL-8
R13296 T14942 T14944 nmod E,IL-8
R13297 T14943 T14944 punct ),IL-8
R13298 T14944 T14939 appos IL-8,secretion
R13299 T14945 T14944 punct ",",IL-8
R13300 T14946 T14944 cc and,IL-8
R13301 T14947 T14948 punct (,F
R13302 T14948 T14950 nmod F,NF-κB
R13303 T14949 T14950 punct ),NF-κB
R13304 T14950 T14944 conj NF-κB,IL-8
R13305 T14951 T14953 nmod /,activity
R13306 T14952 T14953 compound AP-1,activity
R13307 T14953 T14950 dobj activity,NF-κB
R13308 T14954 T14950 prep at,NF-κB
R13309 T14955 T14956 nummod 24,hours
R13310 T14956 T14954 pobj hours,at
R13311 T14957 T14956 punct (,hours
R13312 T14958 T14956 parataxis n,hours
R13313 T14959 T14960 punct =,4
R13314 T14960 T14956 nummod 4,hours
R13315 T14961 T14950 punct ),NF-κB
R13316 T14962 T14922 punct .,treated

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T5503 0-10 NN denotes Disruption
T5504 11-13 IN denotes of
T5505 14-18 NN denotes CFTR
T5506 19-27 NN denotes activity
T5507 28-32 VB denotes does
T5508 33-36 RB denotes not
T5509 37-45 VB denotes increase
T5510 46-51 NN denotes IL-1β
T5511 52-62 NN denotes production
T5512 63-65 IN denotes in
T5513 66-71 NN denotes PBMCs
T5514 72-75 CC denotes and
T5515 76-81 NN denotes THP-1
T5516 82-87 NN denotes cells
T5517 88-89 DT denotes A
T5518 90-98 JJ denotes previous
T5519 99-104 NN denotes study
T5520 105-108 VB denotes has
T5521 109-118 VB denotes indicated
T5522 119-120 DT denotes a
T5523 121-125 NN denotes role
T5524 126-129 IN denotes for
T5525 130-138 NN denotes chloride
T5526 139-142 NN denotes ion
T5527 143-156 NN denotes concentration
T5528 157-159 IN denotes in
T5529 160-171 NN denotes suppression
T5530 172-174 IN denotes of
T5531 175-180 NN denotes NLRP3
T5532 181-193 JJ denotes inflammasome
T5533 194-204 NN denotes activation
T5534 205-206 -LRB- denotes [
T5535 206-208 CD denotes 34
T5536 208-209 -RRB- denotes ]
T5537 211-213 TO denotes To
T5538 214-223 VB denotes determine
T5539 224-231 IN denotes whether
T5540 232-236 NN denotes CFTR
T5541 237-248 NN denotes dysfunction
T5542 249-255 VB denotes alters
T5543 256-261 NN denotes IL-1β
T5544 262-272 NN denotes production
T5545 272-273 -COMMA- denotes ,
T5546 274-279 NN denotes THP-1
T5547 280-285 NN denotes cells
T5548 286-289 CC denotes and
T5549 290-295 NN denotes PBMCs
T5550 296-300 IN denotes from
T5551 301-303 NN denotes CF
T5552 304-312 NN denotes patients
T5553 313-316 CC denotes and
T5554 317-324 JJ denotes healthy
T5555 325-333 NN denotes controls
T5556 334-338 VB denotes were
T5557 339-346 VB denotes treated
T5558 347-351 IN denotes with
T5559 352-355 DT denotes the
T5560 356-360 NN denotes CFTR
T5561 361-370 NN denotes inhibitor
T5562 370-371 -COMMA- denotes ,
T5563 372-382 NN denotes CFTRinh172
T5564 382-383 -COMMA- denotes ,
T5565 384-389 JJ denotes prior
T5566 390-392 TO denotes to
T5567 393-403 NN denotes simulation
T5568 404-408 IN denotes with
T5569 409-413 JJ denotes live
T5570 414-416 NNP denotes P.
T5571 417-427 NN denotes aeruginosa
T5572 429-438 NN denotes Treatment
T5573 439-443 IN denotes with
T5574 444-454 NN denotes CFTRinh172
T5575 455-458 VB denotes did
T5576 459-462 RB denotes not
T5577 463-468 VB denotes alter
T5578 469-474 NN denotes IL-1β
T5579 475-477 CC denotes or
T5580 478-482 NN denotes IL-8
T5581 483-493 NN denotes production
T5582 494-496 IN denotes in
T5583 497-504 JJ denotes control
T5584 505-513 NN denotes subjects
T5585 514-516 CC denotes or
T5586 517-519 NN denotes CF
T5587 520-528 NN denotes patients
T5588 529-530 -LRB- denotes (
T5589 530-534 NN denotes Fig.
T5590 535-539 NN denotes 8a–b
T5591 539-540 -RRB- denotes )
T5592 542-551 RB denotes Similarly
T5593 551-552 -COMMA- denotes ,
T5594 553-558 NN denotes IL-1β
T5595 559-569 NN denotes production
T5596 570-573 VB denotes was
T5597 574-577 RB denotes not
T5598 578-587 JJ denotes different
T5599 588-590 IN denotes in
T5600 591-607 JJ denotes monocyte-derived
T5601 608-619 NN denotes macrophages
T5602 620-622 CC denotes or
T5603 623-628 NN denotes THP-1
T5604 629-637 NN denotes reporter
T5605 638-643 NN denotes cells
T5606 644-651 VB denotes treated
T5607 652-656 IN denotes with
T5608 657-667 NN denotes CFTRinh172
T5609 668-669 -LRB- denotes (
T5610 669-673 NNP denotes Fig.
T5611 674-678 NNP denotes 8c–d
T5612 678-679 -RRB- denotes )
T5613 681-685 NN denotes IL-8
T5614 686-687 -LRB- denotes (
T5615 687-691 NN denotes Fig.
T5616 692-694 NN denotes 8e
T5617 694-695 -RRB- denotes )
T5618 696-699 CC denotes and
T5619 700-705 NN denotes NF-κB
T5620 706-714 NN denotes activity
T5621 715-716 -LRB- denotes (
T5622 716-720 NNP denotes Fig.
T5623 721-723 NN denotes 8f
T5624 723-724 -RRB- denotes )
T5625 725-729 VB denotes were
T5626 730-734 RB denotes also
T5627 735-744 JJ denotes unchanged
T5628 745-747 IN denotes in
T5629 748-766 JJ denotes CFTRinh172-treated
T5630 767-772 NN denotes THP-1
T5631 773-781 NN denotes reporter
T5632 782-787 NN denotes cells
T14739 1140-1148 NN denotes cytes fr
T14674 833-843 NN denotes Disruption
T14675 844-846 IN denotes of
T14676 847-851 NN denotes CFTR
T14677 852-860 NN denotes activity
T14678 861-865 VB denotes does
T14679 866-869 RB denotes not
T14680 870-878 VB denotes increase
T14681 879-884 NN denotes IL-1β
T14682 885-895 NN denotes production
T14683 896-898 IN denotes in
T14684 899-904 NN denotes PBMCs
T14685 905-907 CC denotes or
T14686 908-919 NN denotes macrophages
T14687 921-926 NN denotes PBMCs
T14688 927-931 IN denotes from
T14689 932-934 NN denotes CF
T14690 935-943 NN denotes patients
T14691 944-945 -LRB- denotes (
T14692 945-951 NN denotes n = 15
T14693 951-952 -RRB- denotes )
T14694 953-956 CC denotes and
T14695 957-965 NN denotes controls
T14696 966-967 -LRB- denotes (
T14697 967-973 NN denotes n = 13
T14698 973-974 -RRB- denotes )
T14699 975-979 VB denotes were
T14700 980-987 VB denotes treated
T14701 988-992 IN denotes with
T14702 993-1003 NN denotes CFTRinh172
T14703 1004-1005 -LRB- denotes (
T14704 1005-1007 CD denotes 10
T14705 1008-1010 NN denotes µM
T14706 1010-1011 -RRB- denotes )
T14707 1012-1015 IN denotes for
T14708 1016-1018 CD denotes 18
T14709 1019-1024 NN denotes hours
T14710 1025-1030 RB denotes prior
T14711 1031-1033 TO denotes to
T14712 1034-1045 NN denotes stimulation
T14713 1046-1050 IN denotes with
T14714 1051-1055 JJ denotes live
T14715 1056-1060 NN denotes PAO1
T14716 1061-1062 -LRB- denotes (
T14717 1062-1069 NN denotes MOI = 1
T14718 1069-1070 -RRB- denotes )
T14719 1070-1071 -LRB- denotes .
T14720 1072-1073 NN denotes (
T14721 1073-1074 -RRB- denotes A
T14722 1074-1079 NN denotes ) IL-
T14723 1079-1082 CC denotes 1β
T14724 1082-1083 -LRB- denotes a
T14725 1083-1084 NN denotes n
T14726 1084-1085 -RRB- denotes d
T14727 1086-1090 NN denotes (B)
T14728 1090-1100 NN denotes IL-8 produ
T14729 1100-1103 VB denotes cti
T14730 1103-1111 VB denotes on was m
T14731 1111-1113 IN denotes ea
T14732 1113-1115 CD denotes su
T14733 1115-1121 NN denotes red at
T14734 1122-1123 -LRB- denotes 2
T14735 1123-1124 NN denotes 4
T14736 1125-1126 -RRB- denotes h
T14737 1126-1135 NN denotes ours. (C)
T14738 1136-1140 IN denotes Mono
T14740 1148-1149 -LRB- denotes o
T14741 1149-1154 NN denotes m con
T14742 1154-1155 -RRB- denotes t
T14743 1155-1159 VB denotes rols
T14744 1160-1174 VB denotes (n = 3) were d
T14745 1174-1178 IN denotes iffe
T14746 1178-1189 NN denotes rentiated i
T14747 1206-1217 NN denotes Macrophages
T14748 1218-1222 VB denotes were
T14749 1223-1230 VB denotes treated
T14750 1231-1235 IN denotes with
T14751 1236-1246 NN denotes CFTRinh172
T14752 1246-1247 -COMMA- denotes ,
T14753 1248-1258 VB denotes stimulated
T14754 1259-1261 IN denotes as
T14755 1262-1265 IN denotes per
T14756 1266-1275 NN denotes monocytes
T14757 1275-1276 -COMMA- denotes ,
T14758 1277-1280 CC denotes and
T14759 1281-1289 VB denotes measured
T14760 1290-1293 IN denotes for
T14761 1294-1299 NN denotes IL-1β
T14762 1300-1310 NN denotes production
T14763 1311-1313 IN denotes at
T14764 1314-1316 CD denotes 24
T14765 1317-1322 NN denotes hours
T14766 1324-1329 NN denotes THP-1
T14767 1330-1338 NN denotes reporter
T14768 1339-1344 NN denotes cells
T14769 1345-1349 VB denotes were
T14770 1350-1357 VB denotes treated
T14771 1358-1362 IN denotes with
T14772 1363-1373 NN denotes CFTRinh172
T14773 1374-1376 CD denotes 24
T14774 1377-1382 NN denotes hours
T14775 1383-1388 RB denotes prior
T14776 1389-1391 TO denotes to
T14777 1392-1403 NN denotes stimulation
T14778 1404-1408 IN denotes with
T14779 1409-1413 NN denotes PAO1
T14780 1414-1417 CC denotes and
T14781 1418-1426 VB denotes measured
T14782 1427-1430 IN denotes for
T14783 1431-1432 -LRB- denotes (
T14784 1432-1433 NN denotes D
T14785 1433-1434 -RRB- denotes )
T14786 1435-1440 NN denotes IL-1β
T14787 1441-1450 NN denotes secretion
T14788 1450-1451 -COMMA- denotes ,
T14789 1452-1453 -LRB- denotes (
T14790 1453-1454 NN denotes E
T14791 1454-1455 -RRB- denotes )
T14792 1456-1460 NN denotes IL-8
T14793 1460-1461 -COMMA- denotes ,
T14794 1462-1465 CC denotes and
T14795 1466-1467 -LRB- denotes (
T14796 1467-1468 NN denotes F
T14797 1468-1469 -RRB- denotes )
T14798 1470-1480 NN denotes NF-κB/AP-1
T14799 1481-1489 NN denotes activity
T14800 1490-1492 IN denotes at
T14801 1493-1495 CD denotes 24
T14802 1496-1501 NN denotes hours
T14803 1502-1503 -LRB- denotes (
T14804 1503-1508 NN denotes n = 4
T14805 1508-1509 -RRB- denotes )
R4753 T5503 T5504 arg1Of Disruption,of
R4754 T5503 T5507 arg1Of Disruption,does
R4755 T5503 T5509 arg1Of Disruption,increase
R4756 T5506 T5504 arg2Of activity,of
R4757 T5506 T5505 arg1Of activity,CFTR
R4758 T5509 T5507 arg2Of increase,does
R4759 T5509 T5508 arg1Of increase,not
R4760 T5511 T5509 arg2Of production,increase
R4761 T5511 T5510 arg1Of production,IL-1β
R4762 T5511 T5512 arg1Of production,in
R4763 T5513 T5514 arg1Of PBMCs,and
R4764 T5514 T5512 arg2Of and,in
R4765 T5516 T5514 arg2Of cells,and
R4766 T5516 T5515 arg1Of cells,THP-1
R4767 T5519 T5517 arg1Of study,A
R4768 T5519 T5518 arg1Of study,previous
R4769 T5519 T5520 arg1Of study,has
R4770 T5519 T5521 arg1Of study,indicated
R4771 T5521 T5520 arg2Of indicated,has
R4772 T5523 T5521 arg2Of role,indicated
R4773 T5523 T5522 arg1Of role,a
R4774 T5523 T5524 arg1Of role,for
R4775 T5523 T5528 arg1Of role,in
R4776 T5527 T5524 arg2Of concentration,for
R4777 T5527 T5525 arg1Of concentration,chloride
R4778 T5527 T5526 arg1Of concentration,ion
R4779 T5529 T5528 arg2Of suppression,in
R4780 T5529 T5530 arg1Of suppression,of
R4781 T5533 T5530 arg2Of activation,of
R4782 T5533 T5531 arg1Of activation,NLRP3
R4783 T5533 T5532 arg1Of activation,inflammasome
R4784 T5533 T5534 arg1Of activation,[
R4785 T5535 T5534 arg2Of 34,[
R4786 T5536 T5534 arg3Of ],[
R4787 T5538 T5537 arg1Of determine,To
R4788 T5541 T5540 arg1Of dysfunction,CFTR
R4789 T5541 T5542 arg1Of dysfunction,alters
R4790 T5542 T5538 arg2Of alters,determine
R4791 T5542 T5539 arg1Of alters,whether
R4792 T5544 T5542 arg2Of production,alters
R4793 T5544 T5543 arg1Of production,IL-1β
R4794 T5547 T5546 arg1Of cells,THP-1
R4795 T5547 T5548 arg1Of cells,and
R4796 T5548 T5556 arg1Of and,were
R4797 T5548 T5557 arg2Of and,treated
R4798 T5549 T5548 arg2Of PBMCs,and
R4799 T5549 T5550 arg1Of PBMCs,from
R4800 T5552 T5551 arg1Of patients,CF
R4801 T5552 T5553 arg1Of patients,and
R4802 T5553 T5550 arg2Of and,from
R4803 T5555 T5553 arg2Of controls,and
R4804 T5555 T5554 arg1Of controls,healthy
R4805 T5557 T5537 modOf treated,To
R4806 T5557 T5545 arg1Of treated,","
R4807 T5557 T5556 arg2Of treated,were
R4808 T5557 T5558 arg1Of treated,with
R4809 T5561 T5558 arg2Of inhibitor,with
R4810 T5561 T5559 arg1Of inhibitor,the
R4811 T5561 T5560 arg1Of inhibitor,CFTR
R4812 T5561 T5562 arg1Of inhibitor,","
R4813 T5563 T5562 arg2Of CFTRinh172,","
R4814 T5563 T5564 arg1Of CFTRinh172,","
R4815 T5563 T5565 arg1Of CFTRinh172,prior
R4816 T5565 T5566 arg1Of prior,to
R4817 T5567 T5566 arg2Of simulation,to
R4818 T5567 T5568 arg1Of simulation,with
R4819 T5571 T5568 arg2Of aeruginosa,with
R4820 T5571 T5569 arg1Of aeruginosa,live
R4821 T5571 T5570 arg1Of aeruginosa,P.
R4822 T5572 T5573 arg1Of Treatment,with
R4823 T5572 T5575 arg1Of Treatment,did
R4824 T5572 T5577 arg1Of Treatment,alter
R4825 T5574 T5573 arg2Of CFTRinh172,with
R4826 T5577 T5575 arg2Of alter,did
R4827 T5577 T5576 arg1Of alter,not
R4828 T5578 T5579 arg1Of IL-1β,or
R4829 T5580 T5579 arg2Of IL-8,or
R4830 T5581 T5578 arg1Of production,IL-1β
R4831 T5581 T5580 arg1Of production,IL-8
R4832 T5581 T5582 arg1Of production,in
R4833 T5581 T5585 arg1Of production,or
R4834 T5584 T5582 arg2Of subjects,in
R4835 T5584 T5583 arg1Of subjects,control
R4836 T5585 T5577 arg2Of or,alter
R4837 T5587 T5585 arg2Of patients,or
R4838 T5587 T5586 arg1Of patients,CF
R4839 T5587 T5588 arg1Of patients,(
R4840 T5590 T5588 arg2Of 8a–b,(
R4841 T5590 T5589 arg1Of 8a–b,Fig.
R4842 T5591 T5588 arg3Of ),(
R4843 T5595 T5594 arg1Of production,IL-1β
R4844 T5595 T5596 arg1Of production,was
R4845 T5595 T5598 arg1Of production,different
R4846 T5596 T5592 arg1Of was,Similarly
R4847 T5596 T5593 arg1Of was,","
R4848 T5596 T5597 arg1Of was,not
R4849 T5598 T5596 arg2Of different,was
R4850 T5598 T5599 arg1Of different,in
R4851 T5601 T5600 arg1Of macrophages,monocyte-derived
R4852 T5601 T5602 arg1Of macrophages,or
R4853 T5602 T5599 arg2Of or,in
R4854 T5602 T5606 arg2Of or,treated
R4855 T5605 T5602 arg2Of cells,or
R4856 T5605 T5603 arg1Of cells,THP-1
R4857 T5605 T5604 arg1Of cells,reporter
R4858 T5606 T5607 arg1Of treated,with
R4859 T5608 T5607 arg2Of CFTRinh172,with
R4860 T5608 T5609 arg1Of CFTRinh172,(
R4861 T5611 T5609 arg2Of 8c–d,(
R4862 T5611 T5610 arg1Of 8c–d,Fig.
R4863 T5612 T5609 arg3Of ),(
R4864 T5613 T5614 arg1Of IL-8,(
R4865 T5613 T5618 arg1Of IL-8,and
R4866 T5616 T5614 arg2Of 8e,(
R4867 T5616 T5615 arg1Of 8e,Fig.
R4868 T5617 T5614 arg3Of ),(
R4869 T5618 T5625 arg1Of and,were
R4870 T5618 T5627 arg1Of and,unchanged
R4871 T5620 T5618 arg2Of activity,and
R4872 T5620 T5619 arg1Of activity,NF-κB
R4873 T5620 T5621 arg1Of activity,(
R4874 T5623 T5621 arg2Of 8f,(
R4875 T5623 T5622 arg1Of 8f,Fig.
R4876 T5624 T5621 arg3Of ),(
R4877 T5625 T5626 arg1Of were,also
R4878 T5627 T5625 arg2Of unchanged,were
R4879 T5627 T5628 arg1Of unchanged,in
R4880 T5632 T5628 arg2Of cells,in
R4881 T5632 T5629 arg1Of cells,CFTRinh172-treated
R4882 T5632 T5630 arg1Of cells,THP-1
R4883 T5632 T5631 arg1Of cells,reporter
R13030 T14674 T14675 arg1Of Disruption,of
R13031 T14674 T14678 arg1Of Disruption,does
R13032 T14674 T14680 arg1Of Disruption,increase
R13033 T14677 T14675 arg2Of activity,of
R13034 T14677 T14676 arg1Of activity,CFTR
R13035 T14680 T14678 arg2Of increase,does
R13036 T14680 T14679 arg1Of increase,not
R13037 T14682 T14680 arg2Of production,increase
R13038 T14682 T14681 arg1Of production,IL-1β
R13039 T14682 T14683 arg1Of production,in
R13040 T14684 T14685 arg1Of PBMCs,or
R13041 T14685 T14683 arg2Of or,in
R13042 T14686 T14685 arg2Of macrophages,or
R13043 T14687 T14688 arg1Of PBMCs,from
R13044 T14687 T14699 arg1Of PBMCs,were
R13045 T14687 T14700 arg2Of PBMCs,treated
R13046 T14687 T14743 arg1Of PBMCs,rols
R13047 T14687 T14744 arg2Of PBMCs,(n = 3) were d
R13048 T14690 T14689 arg1Of patients,CF
R13049 T14690 T14691 arg1Of patients,(
R13050 T14690 T14694 arg1Of patients,and
R13051 T14692 T14691 arg2Of n = 15,(
R13052 T14693 T14691 arg3Of ),(
R13053 T14694 T14688 arg2Of and,from
R13054 T14695 T14694 arg2Of controls,and
R13055 T14695 T14696 arg1Of controls,(
R13056 T14697 T14696 arg2Of n = 13,(
R13057 T14698 T14696 arg3Of ),(
R13058 T14700 T14699 arg2Of treated,were
R13059 T14700 T14701 arg1Of treated,with
R13060 T14700 T14723 arg1Of treated,1β
R13061 T14702 T14701 arg2Of CFTRinh172,with
R13062 T14702 T14703 arg1Of CFTRinh172,(
R13063 T14702 T14707 arg1Of CFTRinh172,for
R13064 T14702 T14711 arg1Of CFTRinh172,to
R13065 T14705 T14703 arg2Of µM,(
R13066 T14705 T14704 arg1Of µM,10
R13067 T14706 T14703 arg3Of ),(
R13068 T14709 T14707 arg2Of hours,for
R13069 T14709 T14708 arg1Of hours,18
R13070 T14711 T14710 arg1Of to,prior
R13071 T14712 T14711 arg2Of stimulation,to
R13072 T14712 T14713 arg1Of stimulation,with
R13073 T14715 T14714 arg1Of PAO1,live
R13074 T14715 T14716 arg1Of PAO1,(
R13075 T14715 T14719 arg1Of PAO1,.
R13076 T14717 T14716 arg2Of MOI = 1,(
R13077 T14718 T14716 arg3Of ),(
R13078 T14720 T14719 arg2Of (,.
R13079 T14721 T14719 arg3Of A,.
R13080 T14722 T14713 arg2Of ) IL-,with
R13081 T14722 T14715 arg1Of ) IL-,PAO1
R13082 T14725 T14724 arg2Of n,a
R13083 T14726 T14724 arg3Of d,a
R13084 T14728 T14724 arg1Of IL-8 produ,a
R13085 T14728 T14727 arg1Of IL-8 produ,(B)
R13086 T14728 T14729 arg1Of IL-8 produ,cti
R13087 T14728 T14730 arg2Of IL-8 produ,on was m
R13088 T14730 T14729 arg2Of on was m,cti
R13089 T14730 T14731 arg1Of on was m,ea
R13090 T14735 T14734 arg2Of 4,2
R13091 T14736 T14734 arg3Of h,2
R13092 T14737 T14731 arg2Of ours. (C),ea
R13093 T14737 T14732 arg1Of ours. (C),su
R13094 T14737 T14733 arg1Of ours. (C),red at
R13095 T14737 T14734 arg1Of ours. (C),2
R13096 T14737 T14738 arg1Of ours. (C),Mono
R13097 T14739 T14738 arg2Of cytes fr,Mono
R13098 T14739 T14740 arg1Of cytes fr,o
R13099 T14741 T14740 arg2Of m con,o
R13100 T14742 T14740 arg3Of t,o
R13101 T14744 T14723 arg2Of (n = 3) were d,1β
R13102 T14744 T14729 modOf (n = 3) were d,cti
R13103 T14744 T14743 arg2Of (n = 3) were d,rols
R13104 T14744 T14745 arg1Of (n = 3) were d,iffe
R13105 T14746 T14745 arg2Of rentiated i,iffe
R13106 T14747 T14748 arg1Of Macrophages,were
R13107 T14747 T14749 arg2Of Macrophages,treated
R13108 T14749 T14748 arg2Of treated,were
R13109 T14749 T14750 arg1Of treated,with
R13110 T14751 T14750 arg2Of CFTRinh172,with
R13111 T14751 T14752 arg1Of CFTRinh172,","
R13112 T14751 T14753 arg2Of CFTRinh172,stimulated
R13113 T14751 T14759 arg2Of CFTRinh172,measured
R13114 T14753 T14755 arg1Of stimulated,per
R13115 T14753 T14758 arg1Of stimulated,and
R13116 T14755 T14754 arg1Of per,as
R13117 T14756 T14755 arg2Of monocytes,per
R13118 T14758 T14757 arg1Of and,","
R13119 T14759 T14758 arg2Of measured,and
R13120 T14759 T14760 arg1Of measured,for
R13121 T14759 T14763 arg1Of measured,at
R13122 T14762 T14760 arg2Of production,for
R13123 T14762 T14761 arg1Of production,IL-1β
R13124 T14765 T14763 arg2Of hours,at
R13125 T14765 T14764 arg1Of hours,24
R13126 T14768 T14766 arg1Of cells,THP-1
R13127 T14768 T14767 arg1Of cells,reporter
R13128 T14768 T14769 arg1Of cells,were
R13129 T14768 T14770 arg2Of cells,treated
R13130 T14768 T14781 arg2Of cells,measured
R13131 T14770 T14771 arg1Of treated,with
R13132 T14770 T14775 arg1Of treated,prior
R13133 T14770 T14780 arg1Of treated,and
R13134 T14772 T14771 arg2Of CFTRinh172,with
R13135 T14774 T14773 arg1Of hours,24
R13136 T14775 T14774 arg1Of prior,hours
R13137 T14775 T14776 arg1Of prior,to
R13138 T14777 T14776 arg2Of stimulation,to
R13139 T14777 T14778 arg1Of stimulation,with
R13140 T14779 T14778 arg2Of PAO1,with
R13141 T14780 T14769 arg2Of and,were
R13142 T14781 T14780 arg2Of measured,and
R13143 T14781 T14782 arg1Of measured,for
R13144 T14784 T14783 arg2Of D,(
R13145 T14785 T14783 arg3Of ),(
R13146 T14787 T14783 arg1Of secretion,(
R13147 T14787 T14786 arg1Of secretion,IL-1β
R13148 T14787 T14788 arg1Of secretion,","
R13149 T14788 T14794 arg1Of ",",and
R13150 T14790 T14789 arg2Of E,(
R13151 T14791 T14789 arg3Of ),(
R13152 T14792 T14788 arg2Of IL-8,","
R13153 T14792 T14789 arg1Of IL-8,(
R13154 T14794 T14782 arg2Of and,for
R13155 T14794 T14793 arg1Of and,","
R13156 T14796 T14795 arg2Of F,(
R13157 T14797 T14795 arg3Of ),(
R13158 T14799 T14794 arg2Of activity,and
R13159 T14799 T14795 arg1Of activity,(
R13160 T14799 T14798 arg1Of activity,NF-κB/AP-1
R13161 T14799 T14800 arg1Of activity,at
R13162 T14802 T14800 arg2Of hours,at
R13163 T14802 T14801 arg1Of hours,24
R13164 T14802 T14803 arg1Of hours,(
R13165 T14804 T14803 arg2Of n = 4,(
R13166 T14805 T14803 arg3Of ),(

sentences

Id Subject Object Predicate Lexical cue
T5497 0-87 Sentence denotes Disruption of CFTR activity does not increase IL-1β production in PBMCs and THP-1 cells
T5498 88-210 Sentence denotes A previous study has indicated a role for chloride ion concentration in suppression of NLRP3 inflammasome activation [34].
T5499 211-428 Sentence denotes To determine whether CFTR dysfunction alters IL-1β production, THP-1 cells and PBMCs from CF patients and healthy controls were treated with the CFTR inhibitor, CFTRinh172, prior to simulation with live P. aeruginosa.
T5500 429-541 Sentence denotes Treatment with CFTRinh172 did not alter IL-1β or IL-8 production in control subjects or CF patients (Fig. 8a–b).
T5501 542-680 Sentence denotes Similarly, IL-1β production was not different in monocyte-derived macrophages or THP-1 reporter cells treated with CFTRinh172 (Fig. 8c–d).
T5502 681-788 Sentence denotes IL-8 (Fig. 8e) and NF-κB activity (Fig. 8f) were also unchanged in CFTRinh172-treated THP-1 reporter cells.
T14670 833-920 Sentence denotes Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.
T14671 921-1205 Sentence denotes PBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages.
T14672 1206-1323 Sentence denotes Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours.
T14673 1324-1510 Sentence denotes THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).
T113 0-87 Sentence denotes Disruption of CFTR activity does not increase IL-1β production in PBMCs and THP-1 cells
T114 88-210 Sentence denotes A previous study has indicated a role for chloride ion concentration in suppression of NLRP3 inflammasome activation [34].
T115 211-428 Sentence denotes To determine whether CFTR dysfunction alters IL-1β production, THP-1 cells and PBMCs from CF patients and healthy controls were treated with the CFTR inhibitor, CFTRinh172, prior to simulation with live P. aeruginosa.
T116 429-541 Sentence denotes Treatment with CFTRinh172 did not alter IL-1β or IL-8 production in control subjects or CF patients (Fig. 8a–b).
T117 542-680 Sentence denotes Similarly, IL-1β production was not different in monocyte-derived macrophages or THP-1 reporter cells treated with CFTRinh172 (Fig. 8c–d).
T118 681-788 Sentence denotes IL-8 (Fig. 8e) and NF-κB activity (Fig. 8f) were also unchanged in CFTRinh172-treated THP-1 reporter cells.
T119 789-920 Sentence denotes 10.1371/journal.pone.0037689.g008 Figure 8 Disruption of CFTR activity does not increase IL-1β production in PBMCs or macrophages.
T120 921-1205 Sentence denotes PBMCs from CF patients (n = 15) and controls (n = 13) were treated with CFTRinh172 (10 µM) for 18 hours prior to stimulation with live PAO1 (MOI = 1). (A) IL-1β and (B) IL-8 production was measured at 24 hours. (C) Monocytes from controls (n = 3) were differentiated into macrophages.
T121 1206-1323 Sentence denotes Macrophages were treated with CFTRinh172, stimulated as per monocytes, and measured for IL-1β production at 24 hours.
T122 1324-1510 Sentence denotes THP-1 reporter cells were treated with CFTRinh172 24 hours prior to stimulation with PAO1 and measured for (D) IL-1β secretion, (E) IL-8, and (F) NF-κB/AP-1 activity at 24 hours (n = 4).

2_test

Id Subject Object Predicate Lexical cue
22649552-16301672-88306715 206-208 16301672 denotes 34
T11221 206-208 16301672 denotes 34