PMC:3359311 / 1504-1954 JSONTXT

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T375","span":{"begin":108,"end":113},"obj":"P01584"},{"id":"T376","span":{"begin":198,"end":203},"obj":"P01584"},{"id":"T377","span":{"begin":338,"end":343},"obj":"P01584"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Conclusion\nHematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T63","span":{"begin":83,"end":90},"obj":"Positive_regulation"},{"id":"T64","span":{"begin":108,"end":113},"obj":"Protein"},{"id":"T65","span":{"begin":160,"end":169},"obj":"Positive_regulation"},{"id":"T66","span":{"begin":198,"end":203},"obj":"Protein"},{"id":"T67","span":{"begin":204,"end":213},"obj":"Localization"},{"id":"T68","span":{"begin":328,"end":337},"obj":"Positive_regulation"},{"id":"T69","span":{"begin":337,"end":343},"obj":"Protein"},{"id":"T70","span":{"begin":344,"end":354},"obj":"Gene_expression"},{"id":"T71","span":{"begin":373,"end":376},"obj":"Positive_regulation"}],"relations":[{"id":"R39","pred":"themeOf","subj":"T64","obj":"T63"},{"id":"R40","pred":"themeOf","subj":"T66","obj":"T67"},{"id":"R41","pred":"themeOf","subj":"T67","obj":"T65"},{"id":"R42","pred":"themeOf","subj":"T68","obj":"T71"},{"id":"R43","pred":"themeOf","subj":"T69","obj":"T70"},{"id":"R44","pred":"themeOf","subj":"T70","obj":"T68"}],"attributes":[{"id":"M8","pred":"Speculation","subj":"T71","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Conclusion\nHematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T836","span":{"begin":108,"end":113},"obj":"Protein"},{"id":"T837","span":{"begin":198,"end":203},"obj":"Protein"},{"id":"T838","span":{"begin":239,"end":273},"obj":"Protein"},{"id":"T839","span":{"begin":204,"end":213},"obj":"Localization"},{"id":"T840","span":{"begin":204,"end":213},"obj":"Localization"},{"id":"T841","span":{"begin":338,"end":343},"obj":"Protein"},{"id":"T842","span":{"begin":405,"end":410},"obj":"Protein"},{"id":"T843","span":{"begin":436,"end":440},"obj":"Protein"},{"id":"T844","span":{"begin":344,"end":354},"obj":"Gene_expression"},{"id":"T845","span":{"begin":373,"end":376},"obj":"Positive_regulation"},{"id":"T846","span":{"begin":393,"end":401},"obj":"Positive_regulation"},{"id":"T847","span":{"begin":428,"end":432},"obj":"Negative_regulation"},{"id":"T848","span":{"begin":328,"end":337},"obj":"Positive_regulation"}],"relations":[{"id":"R686","pred":"themeOf","subj":"T837","obj":"T839"},{"id":"R687","pred":"themeOf","subj":"T838","obj":"T840"},{"id":"R688","pred":"themeOf","subj":"T841","obj":"T844"},{"id":"R689","pred":"themeOf","subj":"T842","obj":"T846"},{"id":"R690","pred":"themeOf","subj":"T843","obj":"T847"},{"id":"R691","pred":"themeOf","subj":"T844","obj":"T845"},{"id":"R692","pred":"themeOf","subj":"T844","obj":"T848"}],"text":"Conclusion\nHematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function."}

{"project":"events-check-again","denotations":[{"id":"T793","span":{"begin":83,"end":90},"obj":"Positive_regulation"},{"id":"T794","span":{"begin":108,"end":113},"obj":"Protein"},{"id":"T795","span":{"begin":160,"end":169},"obj":"Positive_regulation"},{"id":"T796","span":{"begin":198,"end":203},"obj":"Protein"},{"id":"T797","span":{"begin":204,"end":213},"obj":"Localization"},{"id":"T798","span":{"begin":328,"end":337},"obj":"Positive_regulation"},{"id":"T799","span":{"begin":337,"end":343},"obj":"Protein"},{"id":"T800","span":{"begin":344,"end":354},"obj":"Gene_expression"},{"id":"T801","span":{"begin":373,"end":376},"obj":"Positive_regulation"}],"relations":[{"id":"R661","pred":"themeOf","subj":"T794","obj":"T793"},{"id":"R662","pred":"themeOf","subj":"T796","obj":"T797"},{"id":"R663","pred":"themeOf","subj":"T797","obj":"T795"},{"id":"R664","pred":"themeOf","subj":"T798","obj":"T801"},{"id":"R665","pred":"themeOf","subj":"T799","obj":"T800"},{"id":"R666","pred":"themeOf","subj":"T800","obj":"T798"}],"attributes":[{"id":"M20","pred":"Speculation","subj":"T801","obj":"true"}],"text":"Conclusion\nHematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function."}

{"project":"GO-CC","denotations":[{"id":"T693","span":{"begin":25,"end":30},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Conclusion\nHematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function."}

{"project":"GO-BP","denotations":[{"id":"T685","span":{"begin":204,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"Conclusion\nHematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function."}

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