
PMC:3359311 / 1504-1954
Annnotations
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T375 | 108-113 | P01584 | denotes | IL-1β |
T376 | 198-203 | P01584 | denotes | IL-1β |
T377 | 338-343 | P01584 | denotes | IL-1β |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T63 | 83-90 | Positive_regulation | denotes | induced | |
T64 | 108-113 | Protein | denotes | IL-1β | |
T65 | 160-169 | Positive_regulation | denotes | preserved | |
T66 | 198-203 | Protein | denotes | IL-1β | |
T67 | 204-213 | Localization | denotes | secretion | |
T68 | 328-337 | Positive_regulation | denotes | increased | |
T69 | 337-343 | Protein | denotes | IL-1β | |
T70 | 344-354 | Gene_expression | denotes | production | |
T71 | 373-376 | Positive_regulation | denotes | due | true |
R39 | T64 | T63 | themeOf | IL-1β,induced | |
R40 | T66 | T67 | themeOf | IL-1β,secretion | |
R41 | T67 | T65 | themeOf | secretion,preserved | |
R42 | T68 | T71 | themeOf | increased,due | |
R43 | T69 | T70 | themeOf | IL-1β,production | |
R44 | T70 | T68 | themeOf | production,increased |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T836 | 108-113 | Protein | denotes | IL-1β |
T837 | 198-203 | Protein | denotes | IL-1β |
T838 | 239-273 | Protein | denotes | CF pathogen Pseudomonas aeruginosa |
T839 | 204-213 | Localization | denotes | secretion |
T840 | 204-213 | Localization | denotes | secretion |
T841 | 338-343 | Protein | denotes | IL-1β |
T842 | 405-410 | Protein | denotes | NF-κB |
T843 | 436-440 | Protein | denotes | CFTR |
T844 | 344-354 | Gene_expression | denotes | production |
T845 | 373-376 | Positive_regulation | denotes | due |
T846 | 393-401 | Positive_regulation | denotes | increase |
T847 | 428-432 | Negative_regulation | denotes | loss |
T848 | 328-337 | Positive_regulation | denotes | increased |
R686 | T837 | T839 | themeOf | IL-1β,secretion |
R687 | T838 | T840 | themeOf | CF pathogen Pseudomonas aeruginosa,secretion |
R688 | T841 | T844 | themeOf | IL-1β,production |
R689 | T842 | T846 | themeOf | NF-κB,increase |
R690 | T843 | T847 | themeOf | CFTR,loss |
R691 | T844 | T845 | themeOf | production,due |
R692 | T844 | T848 | themeOf | production,increased |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T793 | 83-90 | Positive_regulation | denotes | induced | |
T794 | 108-113 | Protein | denotes | IL-1β | |
T795 | 160-169 | Positive_regulation | denotes | preserved | |
T796 | 198-203 | Protein | denotes | IL-1β | |
T797 | 204-213 | Localization | denotes | secretion | |
T798 | 328-337 | Positive_regulation | denotes | increased | |
T799 | 337-343 | Protein | denotes | IL-1β | |
T800 | 344-354 | Gene_expression | denotes | production | |
T801 | 373-376 | Positive_regulation | denotes | due | true |
R661 | T794 | T793 | themeOf | IL-1β,induced | |
R662 | T796 | T797 | themeOf | IL-1β,secretion | |
R663 | T797 | T795 | themeOf | secretion,preserved | |
R664 | T798 | T801 | themeOf | increased,due | |
R665 | T799 | T800 | themeOf | IL-1β,production | |
R666 | T800 | T798 | themeOf | production,increased |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T693 | 25-30 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T685 | 204-213 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T595 | 0-10 | NNP | denotes | Conclusion |
T596 | 11-24 | NNP | denotes | Hematopoeitic |
T597 | 25-30 | NNS | denotes | cells |
T598 | 31-37 | VBP | denotes | appear |
T599 | 38-40 | TO | denotes | to |
T600 | 41-43 | VB | denotes | be |
T601 | 44-47 | DT | denotes | the |
T602 | 48-59 | JJ | denotes | predominant |
T603 | 60-66 | NN | denotes | source |
T604 | 67-69 | IN | denotes | of |
T605 | 70-90 | JJ | denotes | inflammasome-induced |
T606 | 91-107 | JJ | denotes | pro-inflammatory |
T607 | 108-113 | NN | denotes | IL-1β |
T608 | 114-116 | IN | denotes | in |
T609 | 117-120 | NNP | denotes | CF. |
T610 | 121-126 | NNP | denotes | PBMCs |
T611 | 127-134 | VBD | denotes | derived |
T612 | 135-139 | IN | denotes | from |
T613 | 140-142 | NNP | denotes | CF |
T614 | 143-151 | NNS | denotes | subjects |
T615 | 152-159 | VBP | denotes | display |
T616 | 160-169 | VBN | denotes | preserved |
T617 | 170-182 | JJ | denotes | inflammasome |
T618 | 183-193 | NN | denotes | activation |
T619 | 194-197 | CC | denotes | and |
T620 | 198-203 | JJ | denotes | IL-1β |
T621 | 204-213 | NN | denotes | secretion |
T622 | 214-216 | IN | denotes | in |
T623 | 217-225 | NN | denotes | response |
T624 | 226-228 | TO | denotes | to |
T625 | 229-232 | DT | denotes | the |
T626 | 233-238 | JJ | denotes | major |
T627 | 239-241 | NNP | denotes | CF |
T628 | 242-250 | NN | denotes | pathogen |
T629 | 251-262 | NNP | denotes | Pseudomonas |
T630 | 263-273 | NN | denotes | aeruginosa |
T631 | 273-274 | . | denotes | . |
T632 | 275-282 | RB | denotes | However |
T633 | 282-283 | , | denotes | , |
T634 | 284-287 | PRP$ | denotes | our |
T635 | 288-292 | NNS | denotes | data |
T636 | 293-295 | VBP | denotes | do |
T637 | 296-299 | RB | denotes | not |
T638 | 300-307 | VB | denotes | support |
T639 | 308-311 | DT | denotes | the |
T640 | 312-322 | NN | denotes | hypothesis |
T641 | 323-327 | WDT | denotes | that |
T642 | 328-337 | VBD | denotes | increased |
T643 | 338-343 | JJ | denotes | IL-1β |
T644 | 344-354 | NN | denotes | production |
T645 | 355-357 | IN | denotes | in |
T646 | 358-360 | NNP | denotes | CF |
T647 | 361-369 | NNS | denotes | subjects |
T648 | 370-372 | VBZ | denotes | is |
T649 | 373-376 | JJ | denotes | due |
T650 | 377-379 | TO | denotes | to |
T651 | 380-382 | DT | denotes | an |
T652 | 383-392 | JJ | denotes | intrinsic |
T653 | 393-401 | NN | denotes | increase |
T654 | 402-404 | IN | denotes | in |
T655 | 405-410 | JJ | denotes | NF-κB |
T656 | 411-419 | NN | denotes | activity |
T657 | 420-427 | IN | denotes | through |
T658 | 428-432 | NN | denotes | loss |
T659 | 433-435 | IN | denotes | of |
T660 | 436-440 | NNP | denotes | CFTR |
T661 | 441-449 | NN | denotes | function |
T662 | 449-450 | . | denotes | . |
R533 | T595 | T596 | compound | Conclusion,Hematopoeitic |
R534 | T596 | T597 | compound | Hematopoeitic,cells |
R535 | T597 | T598 | nsubj | cells,appear |
R536 | T598 | T598 | ROOT | appear,appear |
R537 | T599 | T600 | aux | to,be |
R538 | T600 | T598 | xcomp | be,appear |
R539 | T601 | T603 | det | the,source |
R540 | T602 | T603 | amod | predominant,source |
R541 | T603 | T600 | attr | source,be |
R542 | T604 | T603 | prep | of,source |
R543 | T605 | T607 | amod | inflammasome-induced,IL-1β |
R544 | T606 | T607 | amod | pro-inflammatory,IL-1β |
R545 | T607 | T604 | pobj | IL-1β,of |
R546 | T608 | T607 | prep | in,IL-1β |
R547 | T609 | T610 | compound | CF.,PBMCs |
R548 | T610 | T608 | pobj | PBMCs,in |
R549 | T611 | T598 | advcl | derived,appear |
R550 | T612 | T611 | prep | from,derived |
R551 | T613 | T614 | compound | CF,subjects |
R552 | T614 | T612 | pobj | subjects,from |
R553 | T615 | T611 | dobj | display,derived |
R554 | T616 | T618 | amod | preserved,activation |
R555 | T617 | T618 | amod | inflammasome,activation |
R556 | T618 | T615 | dobj | activation,display |
R557 | T619 | T618 | cc | and,activation |
R558 | T620 | T621 | amod | IL-1β,secretion |
R559 | T621 | T618 | conj | secretion,activation |
R560 | T622 | T615 | prep | in,display |
R561 | T623 | T622 | pobj | response,in |
R562 | T624 | T623 | prep | to,response |
R563 | T625 | T628 | det | the,pathogen |
R564 | T626 | T628 | amod | major,pathogen |
R565 | T627 | T628 | compound | CF,pathogen |
R566 | T628 | T624 | pobj | pathogen,to |
R567 | T629 | T630 | compound | Pseudomonas,aeruginosa |
R568 | T630 | T628 | appos | aeruginosa,pathogen |
R569 | T631 | T598 | punct | .,appear |
R570 | T632 | T638 | advmod | However,support |
R571 | T633 | T638 | punct | ",",support |
R572 | T634 | T635 | poss | our,data |
R573 | T635 | T638 | nsubj | data,support |
R574 | T636 | T638 | aux | do,support |
R575 | T637 | T638 | neg | not,support |
R576 | T638 | T638 | ROOT | support,support |
R577 | T639 | T640 | det | the,hypothesis |
R578 | T640 | T638 | dobj | hypothesis,support |
R579 | T641 | T642 | nsubj | that,increased |
R580 | T642 | T640 | relcl | increased,hypothesis |
R581 | T643 | T644 | amod | IL-1β,production |
R582 | T644 | T642 | dobj | production,increased |
R583 | T645 | T644 | prep | in,production |
R584 | T646 | T647 | compound | CF,subjects |
R585 | T647 | T645 | pobj | subjects,in |
R586 | T648 | T638 | advcl | is,support |
R587 | T649 | T648 | acomp | due,is |
R588 | T650 | T649 | prep | to,due |
R589 | T651 | T653 | det | an,increase |
R590 | T652 | T653 | amod | intrinsic,increase |
R591 | T653 | T650 | pobj | increase,to |
R592 | T654 | T653 | prep | in,increase |
R593 | T655 | T656 | amod | NF-κB,activity |
R594 | T656 | T654 | pobj | activity,in |
R595 | T657 | T653 | prep | through,increase |
R596 | T658 | T657 | pobj | loss,through |
R597 | T659 | T658 | prep | of,loss |
R598 | T660 | T661 | amod | CFTR,function |
R599 | T661 | T659 | pobj | function,of |
R600 | T662 | T638 | punct | .,support |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T297 | 0-10 | NN | denotes | Conclusion |
T298 | 11-24 | JJ | denotes | Hematopoeitic |
T299 | 25-30 | NN | denotes | cells |
T300 | 31-37 | VB | denotes | appear |
T301 | 38-40 | TO | denotes | to |
T302 | 41-43 | VB | denotes | be |
T303 | 44-47 | DT | denotes | the |
T304 | 48-59 | JJ | denotes | predominant |
T305 | 60-66 | NN | denotes | source |
T306 | 67-69 | IN | denotes | of |
T307 | 70-90 | JJ | denotes | inflammasome-induced |
T308 | 91-107 | JJ | denotes | pro-inflammatory |
T309 | 108-113 | NN | denotes | IL-1β |
T310 | 114-116 | IN | denotes | in |
T311 | 117-119 | NN | denotes | CF |
T312 | 121-126 | NN | denotes | PBMCs |
T313 | 127-134 | VB | denotes | derived |
T314 | 135-139 | IN | denotes | from |
T315 | 140-142 | NN | denotes | CF |
T316 | 143-151 | NN | denotes | subjects |
T317 | 152-159 | VB | denotes | display |
T318 | 160-169 | VB | denotes | preserved |
T319 | 170-182 | JJ | denotes | inflammasome |
T320 | 183-193 | NN | denotes | activation |
T321 | 194-197 | CC | denotes | and |
T322 | 198-203 | NN | denotes | IL-1β |
T323 | 204-213 | NN | denotes | secretion |
T324 | 214-216 | IN | denotes | in |
T325 | 217-225 | NN | denotes | response |
T326 | 226-228 | TO | denotes | to |
T327 | 229-232 | DT | denotes | the |
T328 | 233-238 | JJ | denotes | major |
T329 | 239-241 | NN | denotes | CF |
T330 | 242-250 | NN | denotes | pathogen |
T331 | 251-262 | NN | denotes | Pseudomonas |
T332 | 263-273 | NN | denotes | aeruginosa |
T333 | 275-282 | RB | denotes | However |
T334 | 282-283 | -COMMA- | denotes | , |
T335 | 284-287 | PRP-DOLLAR- | denotes | our |
T336 | 288-292 | NN | denotes | data |
T337 | 293-295 | VB | denotes | do |
T338 | 296-299 | RB | denotes | not |
T339 | 300-307 | VB | denotes | support |
T340 | 308-311 | DT | denotes | the |
T341 | 312-322 | NN | denotes | hypothesis |
T342 | 323-327 | IN | denotes | that |
T343 | 328-337 | VB | denotes | increased |
T344 | 338-343 | NN | denotes | IL-1β |
T345 | 344-354 | NN | denotes | production |
T346 | 355-357 | IN | denotes | in |
T347 | 358-360 | NN | denotes | CF |
T348 | 361-369 | NN | denotes | subjects |
T349 | 370-372 | VB | denotes | is |
T350 | 373-376 | JJ | denotes | due |
T351 | 377-379 | TO | denotes | to |
T352 | 380-382 | DT | denotes | an |
T353 | 383-392 | JJ | denotes | intrinsic |
T354 | 393-401 | NN | denotes | increase |
T355 | 402-404 | IN | denotes | in |
T356 | 405-410 | NN | denotes | NF-κB |
T357 | 411-419 | NN | denotes | activity |
T358 | 420-427 | IN | denotes | through |
T359 | 428-432 | NN | denotes | loss |
T360 | 433-435 | IN | denotes | of |
T361 | 436-440 | NN | denotes | CFTR |
T362 | 441-449 | NN | denotes | function |
R251 | T299 | T298 | arg1Of | cells,Hematopoeitic |
R252 | T299 | T300 | arg1Of | cells,appear |
R253 | T299 | T302 | arg1Of | cells,be |
R254 | T302 | T300 | arg2Of | be,appear |
R255 | T302 | T301 | arg1Of | be,to |
R256 | T305 | T302 | arg2Of | source,be |
R257 | T305 | T303 | arg1Of | source,the |
R258 | T305 | T304 | arg1Of | source,predominant |
R259 | T305 | T306 | arg1Of | source,of |
R260 | T305 | T310 | arg1Of | source,in |
R261 | T309 | T306 | arg2Of | IL-1β,of |
R262 | T309 | T307 | arg1Of | IL-1β,inflammasome-induced |
R263 | T309 | T308 | arg1Of | IL-1β,pro-inflammatory |
R264 | T311 | T310 | arg2Of | CF,in |
R265 | T312 | T313 | arg2Of | PBMCs,derived |
R266 | T312 | T317 | arg1Of | PBMCs,display |
R267 | T313 | T314 | arg1Of | derived,from |
R268 | T316 | T314 | arg2Of | subjects,from |
R269 | T316 | T315 | arg1Of | subjects,CF |
R270 | T317 | T324 | arg1Of | display,in |
R271 | T320 | T318 | arg2Of | activation,preserved |
R272 | T320 | T319 | arg1Of | activation,inflammasome |
R273 | T320 | T321 | arg1Of | activation,and |
R274 | T321 | T317 | arg2Of | and,display |
R275 | T323 | T321 | arg2Of | secretion,and |
R276 | T323 | T322 | arg1Of | secretion,IL-1β |
R277 | T324 | T326 | arg1Of | in,to |
R278 | T325 | T324 | arg2Of | response,in |
R279 | T332 | T324 | arg3Of | aeruginosa,in |
R280 | T332 | T327 | arg1Of | aeruginosa,the |
R281 | T332 | T328 | arg1Of | aeruginosa,major |
R282 | T332 | T329 | arg1Of | aeruginosa,CF |
R283 | T332 | T330 | arg1Of | aeruginosa,pathogen |
R284 | T332 | T331 | arg1Of | aeruginosa,Pseudomonas |
R285 | T336 | T335 | arg1Of | data,our |
R286 | T336 | T337 | arg1Of | data,do |
R287 | T336 | T339 | arg1Of | data,support |
R288 | T339 | T333 | arg1Of | support,However |
R289 | T339 | T334 | arg1Of | support,"," |
R290 | T339 | T337 | arg2Of | support,do |
R291 | T339 | T338 | arg1Of | support,not |
R292 | T341 | T339 | arg2Of | hypothesis,support |
R293 | T341 | T340 | arg1Of | hypothesis,the |
R294 | T345 | T343 | arg2Of | production,increased |
R295 | T345 | T344 | arg1Of | production,IL-1β |
R296 | T345 | T346 | arg1Of | production,in |
R297 | T345 | T349 | arg1Of | production,is |
R298 | T345 | T351 | arg1Of | production,to |
R299 | T348 | T346 | arg2Of | subjects,in |
R300 | T348 | T347 | arg1Of | subjects,CF |
R301 | T349 | T341 | arg2Of | is,hypothesis |
R302 | T349 | T342 | arg1Of | is,that |
R303 | T351 | T349 | arg2Of | to,is |
R304 | T351 | T350 | arg1Of | to,due |
R305 | T354 | T351 | arg2Of | increase,to |
R306 | T354 | T352 | arg1Of | increase,an |
R307 | T354 | T353 | arg1Of | increase,intrinsic |
R308 | T354 | T355 | arg1Of | increase,in |
R309 | T357 | T355 | arg2Of | activity,in |
R310 | T357 | T356 | arg1Of | activity,NF-κB |
R311 | T357 | T358 | arg1Of | activity,through |
R312 | T359 | T358 | arg2Of | loss,through |
R313 | T359 | T360 | arg1Of | loss,of |
R314 | T362 | T360 | arg2Of | function,of |
R315 | T362 | T361 | arg1Of | function,CFTR |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T85 | 0-10 | Sentence | denotes | Conclusion |
T86 | 11-120 | Sentence | denotes | Hematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. |
T87 | 121-274 | Sentence | denotes | PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. |
T88 | 275-450 | Sentence | denotes | However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function. |
T15 | 0-10 | Sentence | denotes | Conclusion |
T16 | 11-120 | Sentence | denotes | Hematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. |
T17 | 121-274 | Sentence | denotes | PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. |
T18 | 275-450 | Sentence | denotes | However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function. |