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investigate the difference in the cytokine levels between the tumor and spleen tissues of the CCR5+/+ and CCR5−/− mice, we conducted a cytokine array assay using a Mouse Proteome Array (Figure 4A). Among 40 tested cytokines, the levels of IL-1Ra, MIG, MIP-1α increased about 686, 9 and 25-fold respectively, in CCR5−/− mice compared to CCR5+/+ mice. Using this technique, no other cytokines were found to be different between the CCR5−/− mice and the CCR5+/+ mice (Figure 4B). Similar altered cytokine levels were found in the spleens of CCR5−/− mice (Figure 4C). Since the IL-1Ra level was the most significantly elevated, the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western blotting. The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/− mice (Figure 4D-G)."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T6682","span":{"begin":813,"end":817},"obj":"Protein"},{"id":"T6681","span":{"begin":755,"end":761},"obj":"Protein"},{"id":"T6680","span":{"begin":645,"end":651},"obj":"Protein"},{"id":"T6679","span":{"begin":577,"end":583},"obj":"Protein"},{"id":"T6678","span":{"begin":541,"end":545},"obj":"Protein"},{"id":"T6677","span":{"begin":454,"end":458},"obj":"Protein"},{"id":"T6676","span":{"begin":433,"end":437},"obj":"Protein"},{"id":"T6675","span":{"begin":339,"end":343},"obj":"Protein"},{"id":"T6674","span":{"begin":314,"end":318},"obj":"Protein"},{"id":"T6673","span":{"begin":255,"end":261},"obj":"Protein"},{"id":"T6672","span":{"begin":250,"end":253},"obj":"Protein"},{"id":"T6671","span":{"begin":242,"end":248},"obj":"Protein"},{"id":"T6670","span":{"begin":109,"end":113},"obj":"Protein"},{"id":"T6669","span":{"begin":97,"end":101},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"To investigate the difference in the cytokine levels between the tumor and spleen tissues of the CCR5+/+ and CCR5−/− mice, we conducted a cytokine array assay using a Mouse Proteome Array (Figure 4A). Among 40 tested cytokines, the levels of IL-1Ra, MIG, MIP-1α increased about 686, 9 and 25-fold respectively, in CCR5−/− mice compared to CCR5+/+ mice. Using this technique, no other cytokines were found to be different between the CCR5−/− mice and the CCR5+/+ mice (Figure 4B). Similar altered cytokine levels were found in the spleens of CCR5−/− mice (Figure 4C). Since the IL-1Ra level was the most significantly elevated, the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western blotting. The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/− mice (Figure 4D-G)."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T7106","span":{"begin":255,"end":261},"obj":"http://www.uniprot.org/uniprot/P10147"},{"id":"T7105","span":{"begin":813,"end":817},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7104","span":{"begin":541,"end":545},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7103","span":{"begin":454,"end":458},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7102","span":{"begin":433,"end":437},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7101","span":{"begin":339,"end":343},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7100","span":{"begin":314,"end":318},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7099","span":{"begin":109,"end":113},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7098","span":{"begin":97,"end":101},"obj":"http://www.uniprot.org/uniprot/P51681"},{"id":"T7096","span":{"begin":755,"end":761},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T7095","span":{"begin":645,"end":651},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T7094","span":{"begin":577,"end":583},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T7093","span":{"begin":242,"end":248},"obj":"http://www.uniprot.org/uniprot/P18510"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"To investigate the difference in the cytokine levels between the tumor and spleen tissues of the CCR5+/+ and CCR5−/− mice, we conducted a cytokine array assay using a Mouse Proteome Array (Figure 4A). Among 40 tested cytokines, the levels of IL-1Ra, MIG, MIP-1α increased about 686, 9 and 25-fold respectively, in CCR5−/− mice compared to CCR5+/+ mice. Using this technique, no other cytokines were found to be different between the CCR5−/− mice and the CCR5+/+ mice (Figure 4B). Similar altered cytokine levels were found in the spleens of CCR5−/− mice (Figure 4C). Since the IL-1Ra level was the most significantly elevated, the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western blotting. The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/− mice (Figure 4D-G)."}

{"project":"UBERON-AE","denotations":[{"id":"T6635","span":{"begin":798,"end":805},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T6634","span":{"begin":672,"end":679},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T6633","span":{"begin":82,"end":89},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T6632","span":{"begin":791,"end":797},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"T6631","span":{"begin":665,"end":671},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"T6630","span":{"begin":75,"end":81},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"}],"text":"To investigate the difference in the cytokine levels between the tumor and spleen tissues of the CCR5+/+ and CCR5−/− mice, we conducted a cytokine array assay using a Mouse Proteome Array (Figure 4A). Among 40 tested cytokines, the levels of IL-1Ra, MIG, MIP-1α increased about 686, 9 and 25-fold respectively, in CCR5−/− mice compared to CCR5+/+ mice. Using this technique, no other cytokines were found to be different between the CCR5−/− mice and the CCR5+/+ mice (Figure 4B). Similar altered cytokine levels were found in the spleens of CCR5−/− mice (Figure 4C). Since the IL-1Ra level was the most significantly elevated, the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western blotting. The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/− mice (Figure 4D-G)."}

{"project":"sentences","denotations":[{"id":"T6642","span":{"begin":737,"end":840},"obj":"Sentence"},{"id":"T6641","span":{"begin":567,"end":736},"obj":"Sentence"},{"id":"T6640","span":{"begin":480,"end":566},"obj":"Sentence"},{"id":"T6639","span":{"begin":353,"end":479},"obj":"Sentence"},{"id":"T6638","span":{"begin":201,"end":352},"obj":"Sentence"},{"id":"T6637","span":{"begin":0,"end":200},"obj":"Sentence"},{"id":"T108","span":{"begin":0,"end":200},"obj":"Sentence"},{"id":"T109","span":{"begin":201,"end":352},"obj":"Sentence"},{"id":"T110","span":{"begin":353,"end":479},"obj":"Sentence"},{"id":"T111","span":{"begin":480,"end":566},"obj":"Sentence"},{"id":"T112","span":{"begin":567,"end":736},"obj":"Sentence"},{"id":"T113","span":{"begin":737,"end":840},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To investigate the difference in the cytokine levels between the tumor and spleen tissues of the CCR5+/+ and CCR5−/− mice, we conducted a cytokine array assay using a Mouse Proteome Array (Figure 4A). Among 40 tested cytokines, the levels of IL-1Ra, MIG, MIP-1α increased about 686, 9 and 25-fold respectively, in CCR5−/− mice compared to CCR5+/+ mice. Using this technique, no other cytokines were found to be different between the CCR5−/− mice and the CCR5+/+ mice (Figure 4B). Similar altered cytokine levels were found in the spleens of CCR5−/− mice (Figure 4C). Since the IL-1Ra level was the most significantly elevated, the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western blotting. The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/− mice (Figure 4D-G)."}

{"project":"simple1","denotations":[{"id":"T6698","span":{"begin":813,"end":817},"obj":"Protein"},{"id":"T6697","span":{"begin":755,"end":761},"obj":"Protein"},{"id":"T6696","span":{"begin":645,"end":651},"obj":"Protein"},{"id":"T6695","span":{"begin":577,"end":583},"obj":"Protein"},{"id":"T6694","span":{"begin":541,"end":545},"obj":"Protein"},{"id":"T6693","span":{"begin":454,"end":458},"obj":"Protein"},{"id":"T6692","span":{"begin":433,"end":437},"obj":"Protein"},{"id":"T6691","span":{"begin":339,"end":343},"obj":"Protein"},{"id":"T6690","span":{"begin":314,"end":318},"obj":"Protein"},{"id":"T6689","span":{"begin":255,"end":261},"obj":"Protein"},{"id":"T6688","span":{"begin":250,"end":253},"obj":"Protein"},{"id":"T6687","span":{"begin":242,"end":248},"obj":"Protein"},{"id":"T6686","span":{"begin":109,"end":113},"obj":"Protein"},{"id":"T6685","span":{"begin":97,"end":101},"obj":"Protein"}],"text":"To investigate the difference in the cytokine levels between the tumor and spleen tissues of the CCR5+/+ and CCR5−/− mice, we conducted a cytokine array assay using a Mouse Proteome Array (Figure 4A). Among 40 tested cytokines, the levels of IL-1Ra, MIG, MIP-1α increased about 686, 9 and 25-fold respectively, in CCR5−/− mice compared to CCR5+/+ mice. Using this technique, no other cytokines were found to be different between the CCR5−/− mice and the CCR5+/+ mice (Figure 4B). Similar altered cytokine levels were found in the spleens of CCR5−/− mice (Figure 4C). Since the IL-1Ra level was the most significantly elevated, the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western blotting. The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/− mice (Figure 4D-G)."}

{"project":"DLUT931","denotations":[{"id":"T7128","span":{"begin":766,"end":777},"obj":"Positive_regulation"},{"id":"T7127","span":{"begin":741,"end":751},"obj":"Gene_expression"},{"id":"T7126","span":{"begin":631,"end":641},"obj":"Gene_expression"},{"id":"T7125","span":{"begin":617,"end":625},"obj":"Positive_regulation"},{"id":"T7124","span":{"begin":262,"end":271},"obj":"Positive_regulation"},{"id":"T7122","span":{"begin":813,"end":817},"obj":"Protein"},{"id":"T7121","span":{"begin":755,"end":761},"obj":"Protein"},{"id":"T7120","span":{"begin":645,"end":651},"obj":"Protein"},{"id":"T7119","span":{"begin":577,"end":583},"obj":"Protein"},{"id":"T7118","span":{"begin":541,"end":545},"obj":"Protein"},{"id":"T7117","span":{"begin":454,"end":458},"obj":"Protein"},{"id":"T7116","span":{"begin":433,"end":437},"obj":"Protein"},{"id":"T7115","span":{"begin":339,"end":343},"obj":"Protein"},{"id":"T7114","span":{"begin":314,"end":318},"obj":"Protein"},{"id":"T7113","span":{"begin":255,"end":261},"obj":"Protein"},{"id":"T7112","span":{"begin":250,"end":253},"obj":"Protein"},{"id":"T7111","span":{"begin":242,"end":248},"obj":"Protein"},{"id":"T7110","span":{"begin":109,"end":113},"obj":"Protein"},{"id":"T7109","span":{"begin":97,"end":101},"obj":"Protein"}],"relations":[{"id":"R4873","pred":"themeOf","subj":"T7111","obj":"T7124"},{"id":"R4874","pred":"themeOf","subj":"T7113","obj":"T7124"},{"id":"R4875","pred":"themeOf","subj":"T7119","obj":"T7125"},{"id":"R4876","pred":"themeOf","subj":"T7120","obj":"T7126"},{"id":"R4877","pred":"themeOf","subj":"T7121","obj":"T7127"},{"id":"R4878","pred":"themeOf","subj":"T7126","obj":"T7125"},{"id":"R4879","pred":"themeOf","subj":"T7127","obj":"T7128"}],"text":"To investigate the difference in the cytokine levels between the tumor and spleen tissues of the CCR5+/+ and CCR5−/− mice, we conducted a cytokine array assay using a Mouse Proteome Array (Figure 4A). Among 40 tested cytokines, the levels of IL-1Ra, MIG, MIP-1α increased about 686, 9 and 25-fold respectively, in CCR5−/− mice compared to CCR5+/+ mice. Using this technique, no other cytokines were found to be different between the CCR5−/− mice and the CCR5+/+ mice (Figure 4B). Similar altered cytokine levels were found in the spleens of CCR5−/− mice (Figure 4C). Since the IL-1Ra level was the most significantly elevated, the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western blotting. The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/− mice (Figure 4D-G)."}

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