PMC:3333881 / 3564-4239 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3333881","sourcedb":"PMC","sourceid":"3333881","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3333881","text":" mangabey, lack aberrant immune activation and do not develop AIDS despite high virus replication (28,29). Thus, understanding the mechanisms of NF-κB deregulation by HIV-1 may provide further insights into AIDS pathogenesis.\nIn HIV-1 entry, the binding of the gp120 viral envelope to CD4 induces the NF-κB activity by activation of IKK (30) and procaspase 8 (31). Following viral integration, the early encoded HIV-1 Tat protein interacts with the HIV-1 RNA and host cell factors to sustain the viral replication. 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