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The HIV-1Lai/Bal-Env infectious molecular clone was constructed by replacing the envelope (env) gp160 amino acids 103–717 of the HIV-1Lai (B subtype that utilizes CXCR4) molecular clone with the corresponding region of HIV-1Bal (B subtype that utilizes CCR5). The HIV-1Lai/Bal-Env chimeric virus uses CCR5 as a secondary receptor. The infectious molecular clone of HIV-198IN22 was constructed using DNA extracted from PBMC that were infected with a primary isolate of HIV-198IN22. HIV-1Lai/Bal-Env and HIV-198IN22 mutant viruses were constructed by introducing point mutations using standard PCR-based mutagenesis methods."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T4475","span":{"begin":666,"end":669},"obj":"Protein"},{"id":"T4474","span":{"begin":473,"end":477},"obj":"Protein"},{"id":"T4473","span":{"begin":449,"end":452},"obj":"Protein"},{"id":"T4472","span":{"begin":326,"end":334},"obj":"Positive_regulation"},{"id":"T4471","span":{"begin":425,"end":429},"obj":"Protein"},{"id":"T4470","span":{"begin":335,"end":340},"obj":"Protein"},{"id":"T4469","span":{"begin":268,"end":273},"obj":"Protein"},{"id":"T4468","span":{"begin":263,"end":266},"obj":"Protein"},{"id":"T4467","span":{"begin":253,"end":261},"obj":"Protein"}],"relations":[{"id":"R3509","pred":"themeOf","subj":"T4470","obj":"T4472"}],"text":"HIV-1 infectious molecular clones\nThe plasmid encoding the full-length infectious molecular clone of HIV-1Lai was obtained from the NIH AIDS Reagent and Reference Program. The HIV-1Lai/Bal-Env infectious molecular clone was constructed by replacing the envelope (env) gp160 amino acids 103–717 of the HIV-1Lai (B subtype that utilizes CXCR4) molecular clone with the corresponding region of HIV-1Bal (B subtype that utilizes CCR5). The HIV-1Lai/Bal-Env chimeric virus uses CCR5 as a secondary receptor. The infectious molecular clone of HIV-198IN22 was constructed using DNA extracted from PBMC that were infected with a primary isolate of HIV-198IN22. HIV-1Lai/Bal-Env and HIV-198IN22 mutant viruses were constructed by introducing point mutations using standard PCR-based mutagenesis methods."}

{"project":"testone","denotations":[{"id":"T4312","span":{"begin":425,"end":429},"obj":"Protein"},{"id":"T4311","span":{"begin":335,"end":340},"obj":"Protein"},{"id":"T4310","span":{"begin":268,"end":273},"obj":"Protein"}],"text":"HIV-1 infectious molecular clones\nThe plasmid encoding the full-length infectious molecular clone of HIV-1Lai was obtained from the NIH AIDS Reagent and Reference Program. The HIV-1Lai/Bal-Env infectious molecular clone was constructed by replacing the envelope (env) gp160 amino acids 103–717 of the HIV-1Lai (B subtype that utilizes CXCR4) molecular clone with the corresponding region of HIV-1Bal (B subtype that utilizes CCR5). The HIV-1Lai/Bal-Env chimeric virus uses CCR5 as a secondary receptor. The infectious molecular clone of HIV-198IN22 was constructed using DNA extracted from PBMC that were infected with a primary isolate of HIV-198IN22. HIV-1Lai/Bal-Env and HIV-198IN22 mutant viruses were constructed by introducing point mutations using standard PCR-based mutagenesis methods."}

{"project":"test3","denotations":[{"id":"T4318","span":{"begin":425,"end":429},"obj":"Protein"},{"id":"T4317","span":{"begin":335,"end":340},"obj":"Protein"},{"id":"T4316","span":{"begin":268,"end":273},"obj":"Protein"},{"id":"T4315","span":{"begin":425,"end":429},"obj":"Protein"},{"id":"T4314","span":{"begin":335,"end":340},"obj":"Protein"},{"id":"T4313","span":{"begin":268,"end":273},"obj":"Protein"}],"text":"HIV-1 infectious molecular clones\nThe plasmid encoding the full-length infectious molecular clone of HIV-1Lai was obtained from the NIH AIDS Reagent and Reference Program. The HIV-1Lai/Bal-Env infectious molecular clone was constructed by replacing the envelope (env) gp160 amino acids 103–717 of the HIV-1Lai (B subtype that utilizes CXCR4) molecular clone with the corresponding region of HIV-1Bal (B subtype that utilizes CCR5). The HIV-1Lai/Bal-Env chimeric virus uses CCR5 as a secondary receptor. The infectious molecular clone of HIV-198IN22 was constructed using DNA extracted from PBMC that were infected with a primary isolate of HIV-198IN22. HIV-1Lai/Bal-Env and HIV-198IN22 mutant viruses were constructed by introducing point mutations using standard PCR-based mutagenesis methods."}