PMC:3320587 / 5587-6081 JSONTXT

{"project":"pmc-enju-pas","denotations":[{"id":"T1771","span":{"begin":482,"end":493},"obj":"NN"},{"id":"T1770","span":{"begin":476,"end":481},"obj":"NN"},{"id":"T1769","span":{"begin":473,"end":475},"obj":"IN"},{"id":"T1768","span":{"begin":461,"end":472},"obj":"NN"},{"id":"T1767","span":{"begin":449,"end":460},"obj":"JJ"},{"id":"T1766","span":{"begin":446,"end":448},"obj":"IN"},{"id":"T1765","span":{"begin":436,"end":445},"obj":"NN"},{"id":"T1764","span":{"begin":427,"end":435},"obj":"JJ"},{"id":"T1763","span":{"begin":425,"end":426},"obj":"DT"},{"id":"T1762","span":{"begin":422,"end":424},"obj":"VB"},{"id":"T1761","span":{"begin":416,"end":421},"obj":"NN"},{"id":"T1760","span":{"begin":411,"end":415},"obj":"IN"},{"id":"T1759","span":{"begin":399,"end":410},"obj":"VB"},{"id":"T1758","span":{"begin":395,"end":398},"obj":"CC"},{"id":"T1757","span":{"begin":393,"end":394},"obj":"-COMMA-"},{"id":"T1756","span":{"begin":385,"end":393},"obj":"NN"},{"id":"T1755","span":{"begin":378,"end":384},"obj":"JJ"},{"id":"T1754","span":{"begin":371,"end":377},"obj":"JJ"},{"id":"T1753","span":{"begin":358,"end":370},"obj":"JJ"},{"id":"T1752","span":{"begin":354,"end":357},"obj":"DT"},{"id":"T1751","span":{"begin":351,"end":353},"obj":"TO"},{"id":"T1750","span":{"begin":340,"end":350},"obj":"NN"},{"id":"T1749","span":{"begin":334,"end":339},"obj":"NN"},{"id":"T1748","span":{"begin":331,"end":333},"obj":"IN"},{"id":"T1747","span":{"begin":323,"end":330},"obj":"NN"},{"id":"T1746","span":{"begin":317,"end":322},"obj":"JJ"},{"id":"T1745","span":{"begin":313,"end":316},"obj":"DT"},{"id":"T1744","span":{"begin":306,"end":312},"obj":"VB"},{"id":"T1743","span":{"begin":298,"end":305},"obj":"NN"},{"id":"T1742","span":{"begin":292,"end":297},"obj":"DT"},{"id":"T1741","span":{"begin":290,"end":291},"obj":"-COMMA-"},{"id":"T1740","span":{"begin":286,"end":290},"obj":"RB"},{"id":"T1739","span":{"begin":278,"end":284},"obj":"NN"},{"id":"T1738","span":{"begin":262,"end":277},"obj":"JJ"},{"id":"T1737","span":{"begin":260,"end":261},"obj":"DT"},{"id":"T1736","span":{"begin":257,"end":259},"obj":"IN"},{"id":"T1735","span":{"begin":247,"end":256},"obj":"NN"},{"id":"T1734","span":{"begin":241,"end":246},"obj":"JJ"},{"id":"T1733","span":{"begin":238,"end":240},"obj":"IN"},{"id":"T1732","span":{"begin":227,"end":237},"obj":"NN"},{"id":"T1731","span":{"begin":222,"end":226},"obj":"NN"},{"id":"T1730","span":{"begin":216,"end":221},"obj":"NN"},{"id":"T1729","span":{"begin":206,"end":215},"obj":"VB"},{"id":"T1728","span":{"begin":196,"end":205},"obj":"NN"},{"id":"T1727","span":{"begin":192,"end":195},"obj":"NN"},{"id":"T1726","span":{"begin":187,"end":191},"obj":"IN"},{"id":"T1725","span":{"begin":175,"end":186},"obj":"VB"},{"id":"T1724","span":{"begin":172,"end":174},"obj":"PRP"},{"id":"T1723","span":{"begin":170,"end":171},"obj":"-COMMA-"},{"id":"T1722","span":{"begin":162,"end":170},"obj":"RB"},{"id":"T1721","span":{"begin":156,"end":160},"obj":"NN"},{"id":"T1720","span":{"begin":152,"end":155},"obj":"CC"},{"id":"T1719","span":{"begin":148,"end":151},"obj":"NN"},{"id":"T1718","span":{"begin":142,"end":147},"obj":"JJ"},{"id":"T1717","span":{"begin":139,"end":141},"obj":"IN"},{"id":"T1716","span":{"begin":127,"end":138},"obj":"NN"},{"id":"T1715","span":{"begin":121,"end":126},"obj":"NN"},{"id":"T1714","span":{"begin":118,"end":120},"obj":"IN"},{"id":"T1713","span":{"begin":106,"end":117},"obj":"NN"},{"id":"T1712","span":{"begin":94,"end":105},"obj":"JJ"},{"id":"T1711","span":{"begin":84,"end":93},"obj":"JJ"},{"id":"T1710","span":{"begin":80,"end":83},"obj":"IN"},{"id":"T1709","span":{"begin":69,"end":79},"obj":"NN"},{"id":"T1708","span":{"begin":61,"end":68},"obj":"JJ"},{"id":"T1707","span":{"begin":58,"end":60},"obj":"IN"},{"id":"T1706","span":{"begin":54,"end":57},"obj":"VB"},{"id":"T1705","span":{"begin":49,"end":53},"obj":"NN"},{"id":"T1704","span":{"begin":41,"end":48},"obj":"NN"},{"id":"T1703","span":{"begin":33,"end":40},"obj":"JJ"},{"id":"T1702","span":{"begin":29,"end":32},"obj":"PRP-DOLLAR-"},{"id":"T1701","span":{"begin":25,"end":28},"obj":"CC"},{"id":"T1700","span":{"begin":19,"end":24},"obj":"NN"},{"id":"T1699","span":{"begin":14,"end":18},"obj":"IN"},{"id":"T1698","span":{"begin":9,"end":13},"obj":"VB"},{"id":"T1697","span":{"begin":6,"end":8},"obj":"PRP"},{"id":"T1696","span":{"begin":4,"end":5},"obj":"-COMMA-"},{"id":"T1695","span":{"begin":0,"end":4},"obj":"RB"}],"relations":[{"id":"R1276","pred":"arg1Of","subj":"T1697","obj":"T1698"},{"id":"R1277","pred":"arg1Of","subj":"T1698","obj":"T1695"},{"id":"R1278","pred":"arg1Of","subj":"T1698","obj":"T1696"},{"id":"R1279","pred":"arg1Of","subj":"T1700","obj":"T1701"},{"id":"R1280","pred":"arg1Of","subj":"T1701","obj":"T1706"},{"id":"R1281","pred":"arg1Of","subj":"T1701","obj":"T1707"},{"id":"R1282","pred":"arg2Of","subj":"T1705","obj":"T1701"},{"id":"R1283","pred":"arg1Of","subj":"T1705","obj":"T1702"},{"id":"R1284","pred":"arg1Of","subj":"T1705","obj":"T1703"},{"id":"R1285","pred":"arg1Of","subj":"T1705","obj":"T1704"},{"id":"R1286","pred":"arg2Of","subj":"T1706","obj":"T1698"},{"id":"R1287","pred":"arg1Of","subj":"T1706","obj":"T1699"},{"id":"R1288","pred":"arg2Of","subj":"T1707","obj":"T1706"},{"id":"R1289","pred":"arg2Of","subj":"T1709","obj":"T1707"},{"id":"R1290","pred":"arg1Of","subj":"T1709","obj":"T1708"},{"id":"R1291","pred":"arg1Of","subj":"T1709","obj":"T1710"},{"id":"R1292","pred":"arg2Of","subj":"T1713","obj":"T1710"},{"id":"R1293","pred":"arg1Of","subj":"T1713","obj":"T1711"},{"id":"R1294","pred":"arg1Of","subj":"T1713","obj":"T1712"},{"id":"R1295","pred":"arg1Of","subj":"T1713","obj":"T1714"},{"id":"R1296","pred":"arg2Of","subj":"T1716","obj":"T1714"},{"id":"R1297","pred":"arg1Of","subj":"T1716","obj":"T1715"},{"id":"R1298","pred":"arg1Of","subj":"T1716","obj":"T1717"},{"id":"R1299","pred":"arg1Of","subj":"T1719","obj":"T1720"},{"id":"R1300","pred":"arg2Of","subj":"T1720","obj":"T1717"},{"id":"R1301","pred":"arg1Of","subj":"T1720","obj":"T1718"},{"id":"R1302","pred":"arg2Of","subj":"T1721","obj":"T1720"},{"id":"R1303","pred":"arg1Of","subj":"T1724","obj":"T1725"},{"id":"R1304","pred":"arg1Of","subj":"T1725","obj":"T1722"},{"id":"R1305","pred":"arg1Of","subj":"T1725","obj":"T1723"},{"id":"R1306","pred":"arg1Of","subj":"T1728","obj":"T1727"},{"id":"R1307","pred":"arg1Of","subj":"T1728","obj":"T1729"},{"id":"R1308","pred":"arg2Of","subj":"T1729","obj":"T1725"},{"id":"R1309","pred":"arg1Of","subj":"T1729","obj":"T1726"},{"id":"R1310","pred":"arg1Of","subj":"T1729","obj":"T1736"},{"id":"R1311","pred":"arg2Of","subj":"T1732","obj":"T1729"},{"id":"R1312","pred":"arg1Of","subj":"T1732","obj":"T1730"},{"id":"R1313","pred":"arg1Of","subj":"T1732","obj":"T1731"},{"id":"R1314","pred":"arg1Of","subj":"T1732","obj":"T1733"},{"id":"R1315","pred":"arg2Of","subj":"T1735","obj":"T1733"},{"id":"R1316","pred":"arg1Of","subj":"T1735","obj":"T1734"},{"id":"R1317","pred":"arg2Of","subj":"T1739","obj":"T1736"},{"id":"R1318","pred":"arg1Of","subj":"T1739","obj":"T1737"},{"id":"R1319","pred":"arg1Of","subj":"T1739","obj":"T1738"},{"id":"R1320","pred":"arg1Of","subj":"T1743","obj":"T1742"},{"id":"R1321","pred":"arg1Of","subj":"T1743","obj":"T1744"},{"id":"R1322","pred":"arg1Of","subj":"T1743","obj":"T1759"},{"id":"R1323","pred":"arg1Of","subj":"T1744","obj":"T1758"},{"id":"R1324","pred":"arg2Of","subj":"T1747","obj":"T1744"},{"id":"R1325","pred":"arg1Of","subj":"T1747","obj":"T1745"},{"id":"R1326","pred":"arg1Of","subj":"T1747","obj":"T1746"},{"id":"R1327","pred":"arg1Of","subj":"T1747","obj":"T1748"},{"id":"R1328","pred":"arg2Of","subj":"T1750","obj":"T1748"},{"id":"R1329","pred":"arg1Of","subj":"T1750","obj":"T1749"},{"id":"R1330","pred":"arg1Of","subj":"T1750","obj":"T1751"},{"id":"R1331","pred":"arg2Of","subj":"T1756","obj":"T1751"},{"id":"R1332","pred":"arg1Of","subj":"T1756","obj":"T1752"},{"id":"R1333","pred":"arg1Of","subj":"T1756","obj":"T1753"},{"id":"R1334","pred":"arg1Of","subj":"T1756","obj":"T1754"},{"id":"R1335","pred":"arg1Of","subj":"T1756","obj":"T1755"},{"id":"R1336","pred":"arg1Of","subj":"T1758","obj":"T1740"},{"id":"R1337","pred":"arg1Of","subj":"T1758","obj":"T1741"},{"id":"R1338","pred":"arg1Of","subj":"T1758","obj":"T1757"},{"id":"R1339","pred":"arg2Of","subj":"T1759","obj":"T1758"},{"id":"R1340","pred":"arg1Of","subj":"T1761","obj":"T1762"},{"id":"R1341","pred":"arg2Of","subj":"T1762","obj":"T1759"},{"id":"R1342","pred":"arg1Of","subj":"T1762","obj":"T1760"},{"id":"R1343","pred":"arg2Of","subj":"T1765","obj":"T1762"},{"id":"R1344","pred":"arg1Of","subj":"T1765","obj":"T1763"},{"id":"R1345","pred":"arg1Of","subj":"T1765","obj":"T1764"},{"id":"R1346","pred":"arg1Of","subj":"T1765","obj":"T1766"},{"id":"R1347","pred":"arg2Of","subj":"T1768","obj":"T1766"},{"id":"R1348","pred":"arg1Of","subj":"T1768","obj":"T1767"},{"id":"R1349","pred":"arg1Of","subj":"T1768","obj":"T1769"},{"id":"R1350","pred":"arg2Of","subj":"T1771","obj":"T1769"},{"id":"R1351","pred":"arg1Of","subj":"T1771","obj":"T1770"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T997","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T996","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T995","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T994","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T993","span":{"begin":19,"end":24},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T1789","span":{"begin":334,"end":339},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1788","span":{"begin":216,"end":221},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1787","span":{"begin":19,"end":24},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1777","span":{"begin":262,"end":267},"obj":"http://www.uniprot.org/uniprot/Q99836"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"GO-BP","denotations":[{"id":"T1034","span":{"begin":378,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T1033","span":{"begin":371,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0045824"},{"id":"T1032","span":{"begin":371,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0045089"},{"id":"T1031","span":{"begin":371,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0002218"},{"id":"T1030","span":{"begin":371,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0045088"},{"id":"T1029","span":{"begin":371,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0002227"},{"id":"T1028","span":{"begin":371,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T1027","span":{"begin":222,"end":237},"obj":"http://purl.obolibrary.org/obo/GO_0010467"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"GO-MF","denotations":[{"id":"T1043","span":{"begin":41,"end":48},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"sentences","denotations":[{"id":"T941","span":{"begin":286,"end":494},"obj":"Sentence"},{"id":"T940","span":{"begin":162,"end":285},"obj":"Sentence"},{"id":"T939","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T31","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T32","span":{"begin":162,"end":285},"obj":"Sentence"},{"id":"T33","span":{"begin":286,"end":494},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"simple1","denotations":[{"id":"T1091","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T1090","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T1089","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T1088","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T1087","span":{"begin":19,"end":24},"obj":"Protein"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T2693","span":{"begin":340,"end":350},"obj":"Gene_expression"},{"id":"T2692","span":{"begin":206,"end":215},"obj":"Positive_regulation"},{"id":"T2691","span":{"begin":227,"end":237},"obj":"Gene_expression"},{"id":"T2685","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T2684","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T2683","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T2682","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T2681","span":{"begin":19,"end":24},"obj":"Protein"}],"relations":[{"id":"R2084","pred":"themeOf","subj":"T2682","obj":"T2691"},{"id":"R2090","pred":"themeOf","subj":"T2684","obj":"T2693"},{"id":"R2096","pred":"themeOf","subj":"T2691","obj":"T2692"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T1874","span":{"begin":340,"end":350},"obj":"Gene_expression"},{"id":"T1873","span":{"begin":206,"end":215},"obj":"Positive_regulation"},{"id":"T1872","span":{"begin":227,"end":237},"obj":"Gene_expression"},{"id":"T1871","span":{"begin":41,"end":48},"obj":"Binding"},{"id":"T1864","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T1863","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T1862","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T1861","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T1860","span":{"begin":19,"end":24},"obj":"Protein"}],"relations":[{"id":"R1388","pred":"themeOf","subj":"T1861","obj":"T1872"},{"id":"R1389","pred":"themeOf","subj":"T1863","obj":"T1874"},{"id":"R1390","pred":"themeOf","subj":"T1872","obj":"T1873"},{"id":"R1387","pred":"themeOf","subj":"T1860","obj":"T1871"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"DLUT931","denotations":[{"id":"T1823","span":{"begin":340,"end":350},"obj":"Gene_expression"},{"id":"T1822","span":{"begin":206,"end":215},"obj":"Positive_regulation"},{"id":"T1821","span":{"begin":227,"end":237},"obj":"Gene_expression"},{"id":"T1820","span":{"begin":41,"end":48},"obj":"Binding"},{"id":"T1813","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T1812","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T1811","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T1810","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T1809","span":{"begin":19,"end":24},"obj":"Protein"}],"relations":[{"id":"R1367","pred":"themeOf","subj":"T1821","obj":"T1822"},{"id":"R1364","pred":"themeOf","subj":"T1809","obj":"T1820"},{"id":"R1365","pred":"themeOf","subj":"T1810","obj":"T1821"},{"id":"R1366","pred":"themeOf","subj":"T1812","obj":"T1823"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T2780","span":{"begin":192,"end":205},"obj":"Regulation"},{"id":"T2774","span":{"begin":216,"end":256},"obj":"Gene_expression"},{"id":"T2773","span":{"begin":331,"end":350},"obj":"Gene_expression"},{"id":"T2772","span":{"begin":172,"end":284},"obj":"Positive_regulation"},{"id":"T2767","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T2763","span":{"begin":156,"end":160},"obj":"Entity"},{"id":"T2756","span":{"begin":449,"end":460},"obj":"Protein"},{"id":"T2752","span":{"begin":14,"end":24},"obj":"Protein"},{"id":"T2741","span":{"begin":262,"end":277},"obj":"Protein"},{"id":"T2740","span":{"begin":84,"end":105},"obj":"Protein"},{"id":"T2733","span":{"begin":148,"end":151},"obj":"Protein"},{"id":"T2723","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T2721","span":{"begin":192,"end":195},"obj":"Protein"},{"id":"T2720","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T2717","span":{"begin":49,"end":53},"obj":"Entity"},{"id":"T2712","span":{"begin":241,"end":256},"obj":"Entity"},{"id":"T2695","span":{"begin":358,"end":370},"obj":"Protein"}],"relations":[{"id":"R2143","pred":"themeOf","subj":"T2721","obj":"T2780"},{"id":"R2144","pred":"themeOf","subj":"T2723","obj":"T2773"},{"id":"R2156","pred":"themeOf","subj":"T2767","obj":"T2774"},{"id":"R2159","pred":"themeOf","subj":"T2774","obj":"T2772"},{"id":"R2161","pred":"causeOf","subj":"T2780","obj":"T2772"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T2624","span":{"begin":222,"end":226},"obj":"NN"},{"id":"T2623","span":{"begin":216,"end":221},"obj":"NNP"},{"id":"T2622","span":{"begin":206,"end":215},"obj":"VBZ"},{"id":"T2621","span":{"begin":196,"end":205},"obj":"NN"},{"id":"T2620","span":{"begin":192,"end":195},"obj":"NNP"},{"id":"T2619","span":{"begin":187,"end":191},"obj":"IN"},{"id":"T2618","span":{"begin":175,"end":186},"obj":"VBP"},{"id":"T2617","span":{"begin":172,"end":174},"obj":"PRP"},{"id":"T2616","span":{"begin":170,"end":171},"obj":","},{"id":"T2615","span":{"begin":162,"end":170},"obj":"RB"},{"id":"T2614","span":{"begin":160,"end":161},"obj":"."},{"id":"T2613","span":{"begin":156,"end":160},"obj":"NNP"},{"id":"T2612","span":{"begin":152,"end":155},"obj":"CC"},{"id":"T2611","span":{"begin":148,"end":151},"obj":"NNP"},{"id":"T2610","span":{"begin":142,"end":147},"obj":"JJ"},{"id":"T2609","span":{"begin":139,"end":141},"obj":"IN"},{"id":"T2608","span":{"begin":127,"end":138},"obj":"NN"},{"id":"T2607","span":{"begin":121,"end":126},"obj":"JJ"},{"id":"T2606","span":{"begin":118,"end":120},"obj":"IN"},{"id":"T2605","span":{"begin":106,"end":117},"obj":"NN"},{"id":"T2604","span":{"begin":94,"end":105},"obj":"JJ"},{"id":"T2603","span":{"begin":84,"end":93},"obj":"JJ"},{"id":"T2602","span":{"begin":80,"end":83},"obj":"IN"},{"id":"T2601","span":{"begin":69,"end":79},"obj":"NN"},{"id":"T2600","span":{"begin":61,"end":68},"obj":"JJ"},{"id":"T2599","span":{"begin":58,"end":60},"obj":"IN"},{"id":"T2598","span":{"begin":54,"end":57},"obj":"VBP"},{"id":"T2597","span":{"begin":49,"end":53},"obj":"NN"},{"id":"T2596","span":{"begin":41,"end":48},"obj":"JJ"},{"id":"T2595","span":{"begin":33,"end":40},"obj":"JJ"},{"id":"T2594","span":{"begin":29,"end":32},"obj":"PRP$"},{"id":"T2593","span":{"begin":25,"end":28},"obj":"CC"},{"id":"T2592","span":{"begin":19,"end":24},"obj":"CD"},{"id":"T2591","span":{"begin":14,"end":18},"obj":"IN"},{"id":"T2590","span":{"begin":9,"end":13},"obj":"VBP"},{"id":"T2589","span":{"begin":6,"end":8},"obj":"PRP"},{"id":"T2588","span":{"begin":4,"end":5},"obj":","},{"id":"T2587","span":{"begin":0,"end":4},"obj":"RB"},{"id":"T2666","span":{"begin":493,"end":494},"obj":"."},{"id":"T2665","span":{"begin":482,"end":493},"obj":"NN"},{"id":"T2664","span":{"begin":476,"end":481},"obj":"JJ"},{"id":"T2663","span":{"begin":473,"end":475},"obj":"IN"},{"id":"T2662","span":{"begin":461,"end":472},"obj":"NN"},{"id":"T2661","span":{"begin":449,"end":460},"obj":"JJ"},{"id":"T2660","span":{"begin":446,"end":448},"obj":"IN"},{"id":"T2659","span":{"begin":436,"end":445},"obj":"NN"},{"id":"T2658","span":{"begin":427,"end":435},"obj":"JJ"},{"id":"T2657","span":{"begin":425,"end":426},"obj":"DT"},{"id":"T2656","span":{"begin":422,"end":424},"obj":"VBZ"},{"id":"T2655","span":{"begin":416,"end":421},"obj":"NNP"},{"id":"T2654","span":{"begin":411,"end":415},"obj":"DT"},{"id":"T2653","span":{"begin":399,"end":410},"obj":"VB"},{"id":"T2652","span":{"begin":395,"end":398},"obj":"CC"},{"id":"T2651","span":{"begin":393,"end":394},"obj":","},{"id":"T2650","span":{"begin":385,"end":393},"obj":"NN"},{"id":"T2649","span":{"begin":378,"end":384},"obj":"JJ"},{"id":"T2648","span":{"begin":371,"end":377},"obj":"NN"},{"id":"T2647","span":{"begin":358,"end":370},"obj":"JJ"},{"id":"T2646","span":{"begin":354,"end":357},"obj":"DT"},{"id":"T2645","span":{"begin":351,"end":353},"obj":"TO"},{"id":"T2644","span":{"begin":340,"end":350},"obj":"NN"},{"id":"T2643","span":{"begin":334,"end":339},"obj":"CD"},{"id":"T2642","span":{"begin":331,"end":333},"obj":"IN"},{"id":"T2641","span":{"begin":323,"end":330},"obj":"NNS"},{"id":"T2640","span":{"begin":317,"end":322},"obj":"VBN"},{"id":"T2639","span":{"begin":313,"end":316},"obj":"DT"},{"id":"T2638","span":{"begin":306,"end":312},"obj":"VBP"},{"id":"T2637","span":{"begin":298,"end":305},"obj":"NNS"},{"id":"T2636","span":{"begin":292,"end":297},"obj":"DT"},{"id":"T2635","span":{"begin":290,"end":291},"obj":","},{"id":"T2634","span":{"begin":286,"end":290},"obj":"RB"},{"id":"T2633","span":{"begin":284,"end":285},"obj":"."},{"id":"T2632","span":{"begin":278,"end":284},"obj":"NN"},{"id":"T2631","span":{"begin":262,"end":277},"obj":"JJ"},{"id":"T2630","span":{"begin":260,"end":261},"obj":"DT"},{"id":"T2629","span":{"begin":257,"end":259},"obj":"IN"},{"id":"T2628","span":{"begin":247,"end":256},"obj":"NNS"},{"id":"T2627","span":{"begin":241,"end":246},"obj":"JJ"},{"id":"T2626","span":{"begin":238,"end":240},"obj":"IN"},{"id":"T2625","span":{"begin":227,"end":237},"obj":"NN"}],"relations":[{"id":"R2025","pred":"pobj","subj":"T2665","obj":"T2663"},{"id":"R2030","pred":"punct","subj":"T2666","obj":"T2638"},{"id":"R2048","pred":"advmod","subj":"T2587","obj":"T2590"},{"id":"R2049","pred":"punct","subj":"T2588","obj":"T2590"},{"id":"R2051","pred":"nsubj","subj":"T2589","obj":"T2590"},{"id":"R2053","pred":"ROOT","subj":"T2590","obj":"T2590"},{"id":"R2054","pred":"mark","subj":"T2591","obj":"T2598"},{"id":"R2055","pred":"nsubj","subj":"T2592","obj":"T2598"},{"id":"R2056","pred":"cc","subj":"T2593","obj":"T2592"},{"id":"R2058","pred":"poss","subj":"T2594","obj":"T2597"},{"id":"R2059","pred":"amod","subj":"T2595","obj":"T2597"},{"id":"R2060","pred":"amod","subj":"T2596","obj":"T2597"},{"id":"R2061","pred":"conj","subj":"T2597","obj":"T2592"},{"id":"R2063","pred":"ccomp","subj":"T2598","obj":"T2590"},{"id":"R2065","pred":"prep","subj":"T2599","obj":"T2598"},{"id":"R2066","pred":"amod","subj":"T2600","obj":"T2601"},{"id":"R2067","pred":"pobj","subj":"T2601","obj":"T2599"},{"id":"R2068","pred":"prep","subj":"T2602","obj":"T2598"},{"id":"R2070","pred":"amod","subj":"T2603","obj":"T2605"},{"id":"R2071","pred":"amod","subj":"T2604","obj":"T2605"},{"id":"R2072","pred":"pobj","subj":"T2605","obj":"T2602"},{"id":"R2073","pred":"prep","subj":"T2606","obj":"T2605"},{"id":"R2074","pred":"compound","subj":"T2607","obj":"T2608"},{"id":"R2078","pred":"pobj","subj":"T2608","obj":"T2606"},{"id":"R2079","pred":"prep","subj":"T2609","obj":"T2605"},{"id":"R2081","pred":"amod","subj":"T2610","obj":"T2611"},{"id":"R2082","pred":"pobj","subj":"T2611","obj":"T2609"},{"id":"R2083","pred":"cc","subj":"T2612","obj":"T2611"},{"id":"R2085","pred":"conj","subj":"T2613","obj":"T2611"},{"id":"R2086","pred":"punct","subj":"T2614","obj":"T2590"},{"id":"R2087","pred":"advmod","subj":"T2615","obj":"T2618"},{"id":"R2088","pred":"punct","subj":"T2616","obj":"T2618"},{"id":"R2089","pred":"nsubj","subj":"T2617","obj":"T2618"},{"id":"R2091","pred":"ROOT","subj":"T2618","obj":"T2618"},{"id":"R2092","pred":"mark","subj":"T2619","obj":"T2622"},{"id":"R2093","pred":"nsubj","subj":"T2620","obj":"T2622"},{"id":"R2094","pred":"nsubj","subj":"T2621","obj":"T2622"},{"id":"R2095","pred":"ccomp","subj":"T2622","obj":"T2618"},{"id":"R2097","pred":"compound","subj":"T2623","obj":"T2625"},{"id":"R2098","pred":"compound","subj":"T2624","obj":"T2625"},{"id":"R2099","pred":"dobj","subj":"T2625","obj":"T2622"},{"id":"R2100","pred":"prep","subj":"T2626","obj":"T2625"},{"id":"R2101","pred":"amod","subj":"T2627","obj":"T2628"},{"id":"R2102","pred":"pobj","subj":"T2628","obj":"T2626"},{"id":"R2103","pred":"prep","subj":"T2629","obj":"T2622"},{"id":"R2104","pred":"det","subj":"T2630","obj":"T2632"},{"id":"R2105","pred":"amod","subj":"T2631","obj":"T2632"},{"id":"R2106","pred":"pobj","subj":"T2632","obj":"T2629"},{"id":"R2108","pred":"punct","subj":"T2633","obj":"T2618"},{"id":"R2109","pred":"advmod","subj":"T2634","obj":"T2638"},{"id":"R2110","pred":"punct","subj":"T2635","obj":"T2638"},{"id":"R2111","pred":"det","subj":"T2636","obj":"T2637"},{"id":"R2112","pred":"nsubj","subj":"T2637","obj":"T2638"},{"id":"R2113","pred":"ROOT","subj":"T2638","obj":"T2638"},{"id":"R2114","pred":"det","subj":"T2639","obj":"T2641"},{"id":"R2115","pred":"amod","subj":"T2640","obj":"T2641"},{"id":"R2116","pred":"dobj","subj":"T2641","obj":"T2638"},{"id":"R2117","pred":"prep","subj":"T2642","obj":"T2641"},{"id":"R2118","pred":"nummod","subj":"T2643","obj":"T2644"},{"id":"R2119","pred":"pobj","subj":"T2644","obj":"T2642"},{"id":"R2121","pred":"prep","subj":"T2645","obj":"T2644"},{"id":"R2122","pred":"det","subj":"T2646","obj":"T2650"},{"id":"R2123","pred":"amod","subj":"T2647","obj":"T2650"},{"id":"R2124","pred":"amod","subj":"T2648","obj":"T2650"},{"id":"R2125","pred":"amod","subj":"T2649","obj":"T2650"},{"id":"R2126","pred":"pobj","subj":"T2650","obj":"T2645"},{"id":"R2127","pred":"punct","subj":"T2651","obj":"T2638"},{"id":"R2128","pred":"cc","subj":"T2652","obj":"T2638"},{"id":"R2129","pred":"conj","subj":"T2653","obj":"T2638"},{"id":"R2130","pred":"mark","subj":"T2654","obj":"T2656"},{"id":"R2131","pred":"nsubj","subj":"T2655","obj":"T2656"},{"id":"R2132","pred":"ccomp","subj":"T2656","obj":"T2653"},{"id":"R2133","pred":"det","subj":"T2657","obj":"T2659"},{"id":"R2135","pred":"amod","subj":"T2658","obj":"T2659"},{"id":"R2136","pred":"attr","subj":"T2659","obj":"T2656"},{"id":"R2137","pred":"prep","subj":"T2660","obj":"T2659"},{"id":"R2138","pred":"amod","subj":"T2661","obj":"T2662"},{"id":"R2139","pred":"pobj","subj":"T2662","obj":"T2660"},{"id":"R2140","pred":"prep","subj":"T2663","obj":"T2662"},{"id":"R2141","pred":"amod","subj":"T2664","obj":"T2665"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T1926","span":{"begin":340,"end":350},"obj":"Gene_expression"},{"id":"T1925","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T1924","span":{"begin":358,"end":361},"obj":"Protein"},{"id":"T1923","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T1922","span":{"begin":206,"end":215},"obj":"Positive_regulation"},{"id":"T1921","span":{"begin":227,"end":237},"obj":"Gene_expression"},{"id":"T1920","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T1919","span":{"begin":216,"end":226},"obj":"Protein"},{"id":"T1918","span":{"begin":19,"end":24},"obj":"Protein"}],"relations":[{"id":"R1415","pred":"themeOf","subj":"T1919","obj":"T1921"},{"id":"R1416","pred":"themeOf","subj":"T1921","obj":"T1922"},{"id":"R1418","pred":"themeOf","subj":"T1923","obj":"T1926"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"testone","denotations":[{"id":"T879","span":{"begin":340,"end":350},"obj":"Gene_expression"},{"id":"T878","span":{"begin":206,"end":215},"obj":"Positive_regulation"},{"id":"T872","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T871","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T870","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T869","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T868","span":{"begin":19,"end":24},"obj":"Protein"}],"relations":[{"id":"R616","pred":"themeOf","subj":"T871","obj":"T879"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}

{"project":"test3","denotations":[{"id":"T923","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T922","span":{"begin":340,"end":350},"obj":"Gene_expression"},{"id":"T921","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T920","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T919","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T918","span":{"begin":19,"end":24},"obj":"Protein"},{"id":"T898","span":{"begin":416,"end":421},"obj":"Protein"},{"id":"T897","span":{"begin":334,"end":339},"obj":"Protein"},{"id":"T896","span":{"begin":262,"end":267},"obj":"Protein"},{"id":"T895","span":{"begin":216,"end":221},"obj":"Protein"},{"id":"T894","span":{"begin":19,"end":24},"obj":"Protein"}],"relations":[{"id":"R626","pred":"themeOf","subj":"T921","obj":"T922"}],"text":"Here, we show that NFAT5 and its cognate binding site are of crucial importance for efficient MTb-induced stimulation of HIV-1 replication in human MDM and PBMC. Moreover, we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner. Thus, these results expand the known stimuli of NFAT5 expression to the PRR-mediated innate immune response, and demonstrate that NFAT5 is a critical modulator of MTb-induced enhancement of HIV-1 replication."}