PMC:3320587 / 4764-5586
Annnotations
2_test
{"project":"2_test","denotations":[{"id":"22496647-12359721-98010784","span":{"begin":638,"end":640},"obj":"12359721"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
pmc-enju-pas
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This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T992","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T991","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T990","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T989","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T988","span":{"begin":111,"end":116},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T1794","span":{"begin":581,"end":595},"obj":"http://www.uniprot.org/uniprot/Q15759"},{"id":"T1793","span":{"begin":581,"end":595},"obj":"http://www.uniprot.org/uniprot/P53778"},{"id":"T1792","span":{"begin":581,"end":595},"obj":"http://www.uniprot.org/uniprot/O15264"},{"id":"T1791","span":{"begin":581,"end":595},"obj":"http://www.uniprot.org/uniprot/Q16539"},{"id":"T1790","span":{"begin":132,"end":138},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1786","span":{"begin":662,"end":667},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1785","span":{"begin":508,"end":513},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1784","span":{"begin":280,"end":285},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1783","span":{"begin":111,"end":116},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T1776","span":{"begin":620,"end":625},"obj":"http://www.uniprot.org/uniprot/Q99836"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
UBERON-AE
{"project":"UBERON-AE","denotations":[{"id":"T924","span":{"begin":791,"end":796},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T1010","span":{"begin":546,"end":563},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T1004","span":{"begin":626,"end":635},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T1026","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T1025","span":{"begin":564,"end":591},"obj":"http://purl.obolibrary.org/obo/GO_0000187"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T1042","span":{"begin":315,"end":322},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T1046","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T1045","span":{"begin":309,"end":322},"obj":"http://purl.obolibrary.org/obo/GO_0051059"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T1053","span":{"begin":304,"end":308},"obj":"http://purl.obolibrary.org/obo/GO_0019013"},{"id":"T1052","span":{"begin":809,"end":814},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1051","span":{"begin":90,"end":95},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
sentences
{"project":"sentences","denotations":[{"id":"T938","span":{"begin":497,"end":822},"obj":"Sentence"},{"id":"T937","span":{"begin":275,"end":496},"obj":"Sentence"},{"id":"T936","span":{"begin":0,"end":274},"obj":"Sentence"},{"id":"T28","span":{"begin":0,"end":274},"obj":"Sentence"},{"id":"T29","span":{"begin":275,"end":496},"obj":"Sentence"},{"id":"T30","span":{"begin":497,"end":822},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
simple1
{"project":"simple1","denotations":[{"id":"T1086","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T1085","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T1084","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T1083","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T1082","span":{"begin":111,"end":116},"obj":"Protein"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T2690","span":{"begin":564,"end":573},"obj":"Positive_regulation"},{"id":"T2689","span":{"begin":141,"end":146},"obj":"Binding"},{"id":"T2680","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T2679","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T2678","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T2677","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T2676","span":{"begin":111,"end":116},"obj":"Protein"}],"relations":[{"id":"R2076","pred":"themeOf","subj":"T2676","obj":"T2689"},{"id":"R2077","pred":"themeOf","subj":"T2677","obj":"T2689"},{"id":"R2080","pred":"themeOf","subj":"T2678","obj":"T2690"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T1870","span":{"begin":564,"end":573},"obj":"Positive_regulation"},{"id":"T1869","span":{"begin":680,"end":688},"obj":"Positive_regulation"},{"id":"T1868","span":{"begin":141,"end":146},"obj":"Binding"},{"id":"T1859","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T1858","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T1857","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T1856","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T1855","span":{"begin":111,"end":116},"obj":"Protein"}],"relations":[{"id":"R1383","pred":"themeOf","subj":"T1855","obj":"T1868"},{"id":"R1384","pred":"themeOf","subj":"T1856","obj":"T1868"},{"id":"R1385","pred":"themeOf","subj":"T1857","obj":"T1870"},{"id":"R1386","pred":"themeOf","subj":"T1859","obj":"T1869"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T1819","span":{"begin":680,"end":688},"obj":"Positive_regulation"},{"id":"T1818","span":{"begin":564,"end":573},"obj":"Positive_regulation"},{"id":"T1817","span":{"begin":141,"end":146},"obj":"Binding"},{"id":"T1808","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T1807","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T1806","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T1805","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T1804","span":{"begin":111,"end":116},"obj":"Protein"}],"relations":[{"id":"R1360","pred":"themeOf","subj":"T1804","obj":"T1817"},{"id":"R1361","pred":"themeOf","subj":"T1805","obj":"T1817"},{"id":"R1362","pred":"themeOf","subj":"T1806","obj":"T1818"},{"id":"R1363","pred":"themeOf","subj":"T1808","obj":"T1819"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T2779","span":{"begin":300,"end":341},"obj":"Localization"},{"id":"T2775","span":{"begin":620,"end":642},"obj":"Positive_regulation"},{"id":"T2766","span":{"begin":692,"end":703},"obj":"Protein"},{"id":"T2760","span":{"begin":300,"end":340},"obj":"Protein"},{"id":"T2757","span":{"begin":280,"end":285},"obj":"Protein"},{"id":"T2755","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T2745","span":{"begin":147,"end":156},"obj":"Entity"},{"id":"T2744","span":{"begin":486,"end":489},"obj":"Protein"},{"id":"T2743","span":{"begin":780,"end":814},"obj":"Entity"},{"id":"T2736","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T2735","span":{"begin":448,"end":464},"obj":"Entity"},{"id":"T2732","span":{"begin":766,"end":775},"obj":"Entity"},{"id":"T2731","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T2726","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T2725","span":{"begin":304,"end":308},"obj":"Entity"},{"id":"T2724","span":{"begin":574,"end":596},"obj":"Protein"},{"id":"T2722","span":{"begin":275,"end":290},"obj":"Entity"},{"id":"T2711","span":{"begin":473,"end":490},"obj":"Entity"},{"id":"T2706","span":{"begin":581,"end":584},"obj":"Protein"},{"id":"T2704","span":{"begin":88,"end":102},"obj":"Entity"},{"id":"T2701","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T2700","span":{"begin":574,"end":596},"obj":"Protein"},{"id":"T2694","span":{"begin":574,"end":596},"obj":"Protein"}],"relations":[{"id":"R2145","pred":"locationOf","subj":"T2725","obj":"T2779"},{"id":"R2146","pred":"causeOf","subj":"T2726","obj":"T2775"},{"id":"R2153","pred":"themeOf","subj":"T2760","obj":"T2779"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
bionlp-st-ge-2016-spacy-parsed
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{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T1917","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T1916","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T1915","span":{"begin":581,"end":595},"obj":"Protein"},{"id":"T1914","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T1913","span":{"begin":291,"end":299},"obj":"Binding"},{"id":"T1912","span":{"begin":291,"end":299},"obj":"Binding"},{"id":"T1911","span":{"begin":304,"end":329},"obj":"Protein"},{"id":"T1910","span":{"begin":280,"end":290},"obj":"Protein"},{"id":"T1905","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T1904","span":{"begin":97,"end":101},"obj":"Protein"},{"id":"T1909","span":{"begin":141,"end":146},"obj":"Binding"},{"id":"T1908","span":{"begin":60,"end":95},"obj":"Protein"},{"id":"T1907","span":{"begin":168,"end":177},"obj":"Protein"},{"id":"T1906","span":{"begin":132,"end":138},"obj":"Protein"}],"relations":[{"id":"R1406","pred":"themeOf","subj":"T1907","obj":"T1909"},{"id":"R1408","pred":"themeOf","subj":"T1908","obj":"T1909"},{"id":"R1409","pred":"themeOf","subj":"T1910","obj":"T1912"},{"id":"R1410","pred":"themeOf","subj":"T1910","obj":"T1913"},{"id":"R1412","pred":"themeOf","subj":"T1911","obj":"T1913"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
testone
{"project":"testone","denotations":[{"id":"T877","span":{"begin":141,"end":146},"obj":"Binding"},{"id":"T867","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T866","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T865","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T864","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T863","span":{"begin":111,"end":116},"obj":"Protein"}],"relations":[{"id":"R614","pred":"themeOf","subj":"T863","obj":"T877"},{"id":"R615","pred":"themeOf","subj":"T864","obj":"T877"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}
test3
{"project":"test3","denotations":[{"id":"T917","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T916","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T915","span":{"begin":564,"end":573},"obj":"Positive_regulation"},{"id":"T914","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T913","span":{"begin":141,"end":146},"obj":"Binding"},{"id":"T912","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T911","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T893","span":{"begin":662,"end":667},"obj":"Protein"},{"id":"T892","span":{"begin":620,"end":625},"obj":"Protein"},{"id":"T891","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T890","span":{"begin":132,"end":138},"obj":"Protein"},{"id":"T889","span":{"begin":111,"end":116},"obj":"Protein"}],"relations":[{"id":"R623","pred":"themeOf","subj":"T911","obj":"T913"},{"id":"R624","pred":"themeOf","subj":"T912","obj":"T913"},{"id":"R625","pred":"themeOf","subj":"T914","obj":"T915"}],"text":"We previously showed that the most primordial member of the nuclear factor of activated T cells (NFAT) family, NFAT5 (also known as TonEBP), binds to a site within the HIV-1 LTR that is highly conserved across all HIV-1 subtypes, and is also conserved in HIV-2 and SIV LTRs. This NFAT5 site overlaps the core NF-κB binding motifs in the LTR and is required for constitutive replication of representative HIV-1 subtype B, C, and E isolates in human primary monocyte-derived macrophages (MDM) [31]. Given that NFAT5 has previously been shown to be transcriptionally activated by the MAP kinase p38, which is downstream of MyD88 signaling, [32], we speculated that NFAT5 may also be involved in MTb-induced activation of HIV-1 replication via a TLR-mediated pathway in monocytes and peripheral blood mononuclear cells (PBMC)."}