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Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T25286","span":{"begin":368,"end":371},"obj":"Protein"},{"id":"T25285","span":{"begin":104,"end":109},"obj":"Protein"},{"id":"T25292","span":{"begin":717,"end":720},"obj":"Protein"},{"id":"T25291","span":{"begin":606,"end":609},"obj":"Protein"},{"id":"T25290","span":{"begin":491,"end":494},"obj":"Protein"},{"id":"T25289","span":{"begin":458,"end":461},"obj":"Protein"},{"id":"T25288","span":{"begin":430,"end":433},"obj":"Protein"},{"id":"T25287","span":{"begin":403,"end":406},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"10.1371/journal.ppat.1002620.g004 Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T25498","span":{"begin":717,"end":720},"obj":"http://www.uniprot.org/uniprot/P03366"},{"id":"T25497","span":{"begin":606,"end":609},"obj":"http://www.uniprot.org/uniprot/P03366"},{"id":"T25496","span":{"begin":717,"end":720},"obj":"http://www.uniprot.org/uniprot/P04585"},{"id":"T25495","span":{"begin":606,"end":609},"obj":"http://www.uniprot.org/uniprot/P04585"},{"id":"T25494","span":{"begin":717,"end":720},"obj":"http://www.uniprot.org/uniprot/P12497"},{"id":"T25493","span":{"begin":606,"end":609},"obj":"http://www.uniprot.org/uniprot/P12497"},{"id":"T25492","span":{"begin":717,"end":720},"obj":"http://www.uniprot.org/uniprot/P04591"},{"id":"T25491","span":{"begin":606,"end":609},"obj":"http://www.uniprot.org/uniprot/P04591"},{"id":"T25490","span":{"begin":491,"end":494},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25489","span":{"begin":458,"end":461},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25488","span":{"begin":430,"end":433},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25487","span":{"begin":403,"end":406},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25486","span":{"begin":368,"end":371},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25485","span":{"begin":168,"end":173},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T25484","span":{"begin":104,"end":109},"obj":"http://www.uniprot.org/uniprot/O94916"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"10.1371/journal.ppat.1002620.g004 Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"GO-MF","denotations":[{"id":"T25294","span":{"begin":174,"end":181},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T25293","span":{"begin":93,"end":100},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"10.1371/journal.ppat.1002620.g004 Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

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Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T25555","span":{"begin":1043,"end":1045},"obj":"Protein"},{"id":"T25554","span":{"begin":1039,"end":1042},"obj":"Protein"},{"id":"T25553","span":{"begin":717,"end":720},"obj":"Protein"},{"id":"T25552","span":{"begin":606,"end":609},"obj":"Protein"},{"id":"T25551","span":{"begin":498,"end":501},"obj":"Protein"},{"id":"T25550","span":{"begin":495,"end":497},"obj":"Protein"},{"id":"T25549","span":{"begin":491,"end":494},"obj":"Protein"},{"id":"T25548","span":{"begin":470,"end":473},"obj":"Protein"},{"id":"T25547","span":{"begin":462,"end":469},"obj":"Protein"},{"id":"T25546","span":{"begin":458,"end":461},"obj":"Protein"},{"id":"T25545","span":{"begin":440,"end":443},"obj":"Protein"},{"id":"T25544","span":{"begin":434,"end":439},"obj":"Protein"},{"id":"T25543","span":{"begin":430,"end":433},"obj":"Protein"},{"id":"T25542","span":{"begin":412,"end":415},"obj":"Protein"},{"id":"T25541","span":{"begin":407,"end":411},"obj":"Protein"},{"id":"T25540","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T25539","span":{"begin":372,"end":374},"obj":"Protein"},{"id":"T25538","span":{"begin":368,"end":371},"obj":"Protein"},{"id":"T25537","span":{"begin":141,"end":151},"obj":"Negative_regulation"},{"id":"T25536","span":{"begin":141,"end":151},"obj":"Negative_regulation"},{"id":"T25535","span":{"begin":141,"end":151},"obj":"Negative_regulation"},{"id":"T25534","span":{"begin":195,"end":214},"obj":"Protein"},{"id":"T25533","span":{"begin":168,"end":187},"obj":"Protein"},{"id":"T25532","span":{"begin":159,"end":164},"obj":"Protein"},{"id":"T25531","span":{"begin":93,"end":100},"obj":"Binding"},{"id":"T25530","span":{"begin":93,"end":100},"obj":"Binding"},{"id":"T25529","span":{"begin":114,"end":119},"obj":"Protein"},{"id":"T25528","span":{"begin":104,"end":109},"obj":"Protein"}],"relations":[{"id":"R18629","pred":"themeOf","subj":"T25528","obj":"T25530"},{"id":"R18630","pred":"themeOf","subj":"T25529","obj":"T25531"},{"id":"R18631","pred":"themeOf","subj":"T25532","obj":"T25535"},{"id":"R18632","pred":"themeOf","subj":"T25533","obj":"T25536"},{"id":"R18633","pred":"themeOf","subj":"T25534","obj":"T25537"}],"text":"10.1371/journal.ppat.1002620.g004 Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"testone","denotations":[{"id":"T25251","span":{"begin":606,"end":609},"obj":"Protein"},{"id":"T25250","span":{"begin":491,"end":494},"obj":"Protein"},{"id":"T25249","span":{"begin":458,"end":461},"obj":"Protein"},{"id":"T25248","span":{"begin":430,"end":433},"obj":"Protein"},{"id":"T25247","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T25246","span":{"begin":368,"end":371},"obj":"Protein"},{"id":"T25245","span":{"begin":104,"end":109},"obj":"Protein"},{"id":"T25253","span":{"begin":93,"end":100},"obj":"Binding"},{"id":"T25252","span":{"begin":717,"end":720},"obj":"Protein"}],"relations":[{"id":"R18446","pred":"themeOf","subj":"T25245","obj":"T25253"}],"text":"10.1371/journal.ppat.1002620.g004 Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"test3","denotations":[{"id":"T25270","span":{"begin":717,"end":720},"obj":"Protein"},{"id":"T25269","span":{"begin":606,"end":609},"obj":"Protein"},{"id":"T25268","span":{"begin":491,"end":494},"obj":"Protein"},{"id":"T25267","span":{"begin":458,"end":461},"obj":"Protein"},{"id":"T25266","span":{"begin":430,"end":433},"obj":"Protein"},{"id":"T25265","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T25264","span":{"begin":368,"end":371},"obj":"Protein"},{"id":"T25263","span":{"begin":104,"end":109},"obj":"Protein"},{"id":"T25262","span":{"begin":93,"end":100},"obj":"Binding"},{"id":"T25261","span":{"begin":717,"end":720},"obj":"Protein"},{"id":"T25260","span":{"begin":606,"end":609},"obj":"Protein"},{"id":"T25259","span":{"begin":491,"end":494},"obj":"Protein"},{"id":"T25258","span":{"begin":458,"end":461},"obj":"Protein"},{"id":"T25257","span":{"begin":430,"end":433},"obj":"Protein"},{"id":"T25256","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T25255","span":{"begin":368,"end":371},"obj":"Protein"},{"id":"T25254","span":{"begin":104,"end":109},"obj":"Protein"}],"relations":[{"id":"R18447","pred":"themeOf","subj":"T25263","obj":"T25262"}],"text":"10.1371/journal.ppat.1002620.g004 Figure 4 MTb-induced HIV-1 replication in PBMC depends on binding of NFAT5 and NF-κB to the LTR.\nSpecific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}