PMC:3317373 / 20458-20739 JSONTXT

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conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T7341","span":{"begin":111,"end":115},"obj":"Protein"},{"id":"T7340","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T7339","span":{"begin":94,"end":99},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T8386","span":{"begin":101,"end":105},"obj":"http://www.uniprot.org/uniprot/P05231"},{"id":"T8371","span":{"begin":87,"end":92},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8379","span":{"begin":94,"end":99},"obj":"http://www.uniprot.org/uniprot/P01584"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"GO-BP","denotations":[{"id":"T7367","span":{"begin":134,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T7355","span":{"begin":139,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T7345","span":{"begin":45,"end":64},"obj":"http://purl.obolibrary.org/obo/GO_0051092"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"GO-MF","denotations":[{"id":"T8289","span":{"begin":101,"end":105},"obj":"http://purl.obolibrary.org/obo/GO_0005138"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"GO-CC","denotations":[{"id":"T8298","span":{"begin":134,"end":138},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"sentences","denotations":[{"id":"T7247","span":{"begin":182,"end":281},"obj":"Sentence"},{"id":"T7246","span":{"begin":0,"end":181},"obj":"Sentence"},{"id":"T192","span":{"begin":0,"end":181},"obj":"Sentence"},{"id":"T193","span":{"begin":182,"end":281},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"ICD10","denotations":[{"id":"T8277","span":{"begin":174,"end":180},"obj":"http://purl.bioontology.org/ontology/ICD10/T14.9"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"simple1","denotations":[{"id":"T8356","span":{"begin":111,"end":115},"obj":"Protein"},{"id":"T8355","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T8354","span":{"begin":94,"end":99},"obj":"Protein"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T9937","span":{"begin":73,"end":83},"obj":"Gene_expression"},{"id":"T9936","span":{"begin":33,"end":40},"obj":"Positive_regulation"},{"id":"T9915","span":{"begin":111,"end":115},"obj":"Protein"},{"id":"T9914","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T9913","span":{"begin":94,"end":99},"obj":"Protein"}],"relations":[{"id":"R8164","pred":"themeOf","subj":"T9913","obj":"T9937"},{"id":"R8165","pred":"themeOf","subj":"T9914","obj":"T9937"},{"id":"R8166","pred":"themeOf","subj":"T9915","obj":"T9937"},{"id":"R8202","pred":"themeOf","subj":"T9937","obj":"T9936"},{"id":"R8205","pred":"themeOf","subj":"T9937","obj":"T9936"},{"id":"R8206","pred":"themeOf","subj":"T9937","obj":"T9936"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

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{"project":"DLUT931","denotations":[{"id":"T8443","span":{"begin":45,"end":55},"obj":"Positive_regulation"},{"id":"T8442","span":{"begin":73,"end":83},"obj":"Gene_expression"},{"id":"T8420","span":{"begin":111,"end":115},"obj":"Protein"},{"id":"T8419","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T8418","span":{"begin":94,"end":99},"obj":"Protein"}],"relations":[{"id":"R6839","pred":"themeOf","subj":"T8418","obj":"T8442"},{"id":"R6865","pred":"themeOf","subj":"T8442","obj":"T8443"},{"id":"R6840","pred":"themeOf","subj":"T8419","obj":"T8442"},{"id":"R6841","pred":"themeOf","subj":"T8420","obj":"T8442"},{"id":"R6866","pred":"themeOf","subj":"T8442","obj":"T8443"},{"id":"R6867","pred":"themeOf","subj":"T8442","obj":"T8443"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

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conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

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{"project":"testone","denotations":[{"id":"T7107","span":{"begin":73,"end":83},"obj":"Gene_expression"},{"id":"T7106","span":{"begin":45,"end":55},"obj":"Positive_regulation"},{"id":"T7105","span":{"begin":33,"end":40},"obj":"Positive_regulation"},{"id":"T7104","span":{"begin":15,"end":24},"obj":"Negative_regulation"},{"id":"T7079","span":{"begin":111,"end":115},"obj":"Protein"},{"id":"T7078","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T7077","span":{"begin":94,"end":99},"obj":"Protein"}],"relations":[{"id":"R5824","pred":"themeOf","subj":"T7077","obj":"T7107"},{"id":"R5825","pred":"themeOf","subj":"T7078","obj":"T7107"},{"id":"R5826","pred":"themeOf","subj":"T7079","obj":"T7107"},{"id":"R5833","pred":"themeOf","subj":"T7106","obj":"T7105"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}

{"project":"test3","denotations":[{"id":"T7193","span":{"begin":111,"end":115},"obj":"Protein"},{"id":"T7192","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T7191","span":{"begin":94,"end":99},"obj":"Protein"},{"id":"T7190","span":{"begin":73,"end":83},"obj":"Gene_expression"},{"id":"T7189","span":{"begin":45,"end":55},"obj":"Positive_regulation"},{"id":"T7188","span":{"begin":33,"end":40},"obj":"Positive_regulation"},{"id":"T7187","span":{"begin":15,"end":24},"obj":"Negative_regulation"},{"id":"T7135","span":{"begin":111,"end":115},"obj":"Protein"},{"id":"T7134","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T7133","span":{"begin":94,"end":99},"obj":"Protein"}],"relations":[{"id":"R5864","pred":"themeOf","subj":"T7189","obj":"T7188"},{"id":"R5865","pred":"themeOf","subj":"T7191","obj":"T7190"},{"id":"R5866","pred":"themeOf","subj":"T7192","obj":"T7190"},{"id":"R5867","pred":"themeOf","subj":"T7193","obj":"T7190"}],"text":"In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury. These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI."}