PMC:3317373 / 19484-20457 JSONTXT

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{"project":"ICD10","denotations":[{"id":"T8276","span":{"begin":947,"end":953},"obj":"http://purl.bioontology.org/ontology/ICD10/T14.9"},{"id":"T8275","span":{"begin":688,"end":694},"obj":"http://purl.bioontology.org/ontology/ICD10/T14.9"},{"id":"T8288","span":{"begin":493,"end":518},"obj":"http://purl.bioontology.org/ontology/ICD10/I66.9"}],"text":"It has been confirmed that Nrf2 is mainly detected in nucleus of astrocytes after TBI [18]. In view of the fact that Nrf2 is a transcription factor which should take function mainly in nucleus, it can be reasoned that astrocytes may be one kind of respondent cells in activation of Nrf2-ARE pathway after TBI. Previous study identified the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes after treatment with LPS or oxyhemoglobin [27, 28]. Another study revealed that after middle cerebral artery occlusion, MMP9-positive astrocytes were observed in brain tissues by immunohistochemistry [29]. Those results indicate the role of astrocytes in inflammatory process after brain injury. But till now, there is no study focused on the relationship among astrocytes, Nrf2, and proinflammatory mediators after TBI. Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9 in Nrf2 knockout astrocytes after scratch injury for the first time."}

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In view of the fact that Nrf2 is a transcription factor which should take function mainly in nucleus, it can be reasoned that astrocytes may be one kind of respondent cells in activation of Nrf2-ARE pathway after TBI. Previous study identified the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes after treatment with LPS or oxyhemoglobin [27, 28]. Another study revealed that after middle cerebral artery occlusion, MMP9-positive astrocytes were observed in brain tissues by immunohistochemistry [29]. Those results indicate the role of astrocytes in inflammatory process after brain injury. But till now, there is no study focused on the relationship among astrocytes, Nrf2, and proinflammatory mediators after TBI. Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9 in Nrf2 knockout astrocytes after scratch injury for the first time."}

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