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{"project":"test3","denotations":[{"id":"T7119","span":{"begin":176,"end":181},"obj":"Protein"},{"id":"T7118","span":{"begin":120,"end":124},"obj":"Protein"},{"id":"T7117","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T7116","span":{"begin":56,"end":60},"obj":"Protein"},{"id":"T7115","span":{"begin":23,"end":28},"obj":"Protein"},{"id":"T7155","span":{"begin":176,"end":181},"obj":"Protein"},{"id":"T7154","span":{"begin":120,"end":124},"obj":"Protein"},{"id":"T7153","span":{"begin":102,"end":116},"obj":"Positive_regulation"},{"id":"T7152","span":{"begin":94,"end":101},"obj":"Positive_regulation"},{"id":"T7151","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T7150","span":{"begin":56,"end":60},"obj":"Protein"},{"id":"T7149","span":{"begin":23,"end":28},"obj":"Protein"}],"relations":[{"id":"R5845","pred":"causeOf","subj":"T7151","obj":"T7152"},{"id":"R5846","pred":"themeOf","subj":"T7153","obj":"T7152"},{"id":"R5847","pred":"themeOf","subj":"T7154","obj":"T7153"}],"text":"For example, TNF-α and IL-1β are potent stimulators for MMP9 in astrocytes [12, 13], and IL-6 induces overexpression of MMP9 in human colon carcinoma cells [14], and TNF-α and IL-1β also can induce activation of NF-κB [15, 16]."}