PMC:3317373 / 15826-16891 JSONTXT

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For example, TNF-α and IL-1β are potent stimulators for MMP9 in astrocytes [12, 13], and IL-6 induces overexpression of MMP9 in human colon carcinoma cells [14], and TNF-α and IL-1β also can induce activation of NF-κB [15, 16]. This autoregulatory loop extremely aggravates the damaging effect of inflammation and induces secondary injury to brain. 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