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2_test

Id Subject Object Predicate Lexical cue
22529521-16230799-67992090 507-508 16230799 denotes 2
22529521-9547234-67992091 510-511 9547234 denotes 9
22529521-15680377-67992092 721-722 15680377 denotes 3
22529521-19574840-67992093 724-726 19574840 denotes 10
22529521-19577550-67992094 728-730 19577550 denotes 11
22529521-8945720-67992095 1099-1101 8945720 denotes 12
22529521-8719627-67992096 1103-1105 8719627 denotes 13
22529521-21114487-67992097 1180-1182 21114487 denotes 14
22529521-15269258-67992098 1242-1244 15269258 denotes 15
22529521-10340762-67992099 1246-1248 10340762 denotes 16
22529521-19430250-67992100 1735-1737 19430250 denotes 17
22529521-18162315-67992101 1952-1954 18162315 denotes 18
22529521-19515491-67992102 2214-2216 19515491 denotes 19
22529521-15856023-67992103 3031-3033 15856023 denotes 21
22529521-15139523-67992104 3173-3175 15139523 denotes 22
22529521-18715849-67992105 3350-3351 18715849 denotes 4
22529521-19125683-67992106 3353-3354 19125683 denotes 5
22529521-19394962-67992107 3356-3358 19394962 denotes 23
22529521-16585964-67992108 3626-3628 16585964 denotes 24
22529521-18241676-67992109 3881-3883 18241676 denotes 25
22529521-20486765-67992110 4062-4064 20486765 denotes 26
22529521-18162315-67992111 4154-4156 18162315 denotes 18
22529521-7572279-67992112 4510-4512 7572279 denotes 27
22529521-21833844-67992113 4514-4516 21833844 denotes 28
22529521-19507272-67992114 4668-4670 19507272 denotes 29

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T8267 5318-5321 NN denotes TBI
T8266 5312-5317 IN denotes after
T8265 5304-5311 NN denotes therapy
T8264 5286-5303 JJ denotes anti-inflammatory
T8263 5282-5285 IN denotes for
T8262 5275-5281 NN denotes target
T8261 5265-5274 JJ denotes important
T8260 5262-5264 DT denotes an
T8259 5259-5261 VB denotes be
T8258 5255-5258 MD denotes may
T8257 5250-5254 NN denotes Nrf2
T8256 5245-5249 IN denotes that
T8255 5237-5244 VB denotes suggest
T8254 5229-5236 NN denotes results
T8253 5223-5228 DT denotes These
T8252 5215-5221 NN denotes injury
T8251 5207-5214 NN denotes scratch
T8250 5201-5206 IN denotes after
T8249 5190-5200 NN denotes astrocytes
T8248 5187-5189 IN denotes in
T8247 5180-5186 NN denotes deaths
T8246 5175-5179 NN denotes cell
T8245 5170-5174 JJ denotes more
T8244 5167-5169 IN denotes in
T8243 5157-5166 VB denotes resulting
T8242 5152-5156 NN denotes MMP9
T8241 5148-5151 CC denotes and
T8240 5146-5147 -COMMA- denotes ,
T8239 5142-5146 NN denotes IL-6
T8238 5140-5141 -COMMA- denotes ,
T8237 5135-5140 NN denotes IL-1β
T8236 5133-5134 -COMMA- denotes ,
T8235 5128-5133 NN denotes TNF-α
T8234 5125-5127 IN denotes of
T8233 5114-5124 NN denotes expression
T8232 5110-5113 DT denotes the
T8231 5106-5109 CC denotes and
T8230 5100-5105 NN denotes NF-κB
T8229 5097-5099 IN denotes of
T8228 5086-5096 NN denotes activation
T8227 5082-5085 DT denotes the
T8226 5074-5081 VB denotes induced
T8225 5069-5073 NN denotes Nrf2
T8224 5066-5068 IN denotes of
T8223 5056-5065 NN denotes depletion
T8222 5054-5055 -COMMA- denotes ,
T8221 5044-5054 NN denotes conclusion
T8220 5041-5043 IN denotes In
T8219 5035-5039 NN denotes time
T8218 5029-5034 JJ denotes first
T8217 5025-5028 DT denotes the
T8216 5021-5024 IN denotes for
T8215 5014-5020 NN denotes injury
T8214 5006-5013 NN denotes scratch
T8213 5000-5005 IN denotes after
T8212 4989-4999 NN denotes astrocytes
T8211 4980-4988 NN denotes knockout
T8210 4975-4979 NN denotes Nrf2
T8209 4972-4974 IN denotes in
T8208 4967-4971 NN denotes MMP9
T8207 4963-4966 CC denotes and
T8206 4961-4962 -COMMA- denotes ,
T8205 4957-4961 NN denotes IL-6
T8204 4955-4956 -COMMA- denotes ,
T8203 4950-4955 NN denotes IL-1β
T8202 4948-4949 -COMMA- denotes ,
T8201 4943-4948 NN denotes TNF-α
T8200 4940-4942 IN denotes of
T8199 4929-4939 NN denotes expression
T8198 4917-4928 VB denotes upregulated
T8197 4913-4916 DT denotes the
T8196 4900-4912 VB denotes demonstrated
T8195 4892-4899 NN denotes results
T8194 4888-4891 PRP-DOLLAR- denotes Our
T8193 4883-4886 NN denotes TBI
T8192 4877-4882 IN denotes after
T8191 4867-4876 NN denotes mediators
T8190 4851-4866 JJ denotes proinflammatory
T8189 4847-4850 CC denotes and
T8188 4845-4846 -COMMA- denotes ,
T8187 4841-4845 NN denotes Nrf2
T8186 4839-4840 -COMMA- denotes ,
T8185 4829-4839 NN denotes astrocytes
T8184 4823-4828 IN denotes among
T8183 4810-4822 NN denotes relationship
T8182 4806-4809 DT denotes the
T8181 4803-4805 IN denotes on
T8180 4795-4802 VB denotes focused
T8179 4789-4794 NN denotes study
T8178 4786-4788 DT denotes no
T8177 4783-4785 VB denotes is
T8176 4777-4782 EX denotes there
T8175 4775-4776 -COMMA- denotes ,
T8174 4772-4775 RB denotes now
T8173 4767-4771 RB denotes till
T8172 4763-4766 CC denotes But
T8171 4755-4761 NN denotes injury
T8170 4749-4754 NN denotes brain
T8169 4743-4748 IN denotes after
T8168 4735-4742 NN denotes process
T8167 4722-4734 JJ denotes inflammatory
T8166 4719-4721 IN denotes in
T8165 4708-4718 NN denotes astrocytes
T8164 4705-4707 IN denotes of
T8163 4700-4704 NN denotes role
T8162 4696-4699 DT denotes the
T8161 4687-4695 VB denotes indicate
T8160 4679-4686 NN denotes results
T8159 4673-4678 DT denotes Those
T8158 4670-4671 -RRB- denotes ]
T8157 4668-4670 CD denotes 29
T8156 4667-4668 -LRB- denotes [
T8155 4646-4666 NN denotes immunohistochemistry
T8154 4643-4645 IN denotes by
T8153 4635-4642 NN denotes tissues
T8152 4629-4634 NN denotes brain
T8151 4626-4628 IN denotes in
T8150 4617-4625 VB denotes observed
T8149 4612-4616 VB denotes were
T8148 4601-4611 NN denotes astrocytes
T8147 4587-4600 JJ denotes MMP9-positive
T8146 4585-4586 -COMMA- denotes ,
T8145 4576-4585 NN denotes occlusion
T8144 4569-4575 NN denotes artery
T8143 4560-4568 JJ denotes cerebral
T8142 4553-4559 JJ denotes middle
T8141 4547-4552 IN denotes after
T8140 4542-4546 IN denotes that
T8139 4533-4541 VB denotes revealed
T8138 4527-4532 NN denotes study
T8137 4519-4526 DT denotes Another
T8136 4516-4517 -RRB- denotes ]
T8135 4514-4516 CD denotes 28
T8134 4512-4513 -COMMA- denotes ,
T8133 4510-4512 CD denotes 27
T8132 4509-4510 -LRB- denotes [
T8131 4495-4508 NN denotes oxyhemoglobin
T8130 4492-4494 CC denotes or
T8129 4488-4491 NN denotes LPS
T8128 4483-4487 IN denotes with
T8127 4473-4482 NN denotes treatment
T8126 4467-4472 IN denotes after
T8125 4456-4466 NN denotes astrocytes
T8124 4447-4455 VB denotes cultured
T8123 4444-4446 IN denotes in
T8122 4439-4443 NN denotes IL-6
T8121 4435-4438 CC denotes and
T8120 4433-4434 -COMMA- denotes ,
T8119 4428-4433 NN denotes IL-1β
T8118 4426-4427 -COMMA- denotes ,
T8117 4421-4426 NN denotes TNF-α
T8116 4418-4420 IN denotes of
T8115 4407-4417 NN denotes expression
T8114 4403-4406 DT denotes the
T8113 4392-4402 VB denotes identified
T8112 4386-4391 NN denotes study
T8111 4377-4385 JJ denotes Previous
T8110 4372-4375 NN denotes TBI
T8109 4366-4371 IN denotes after
T8108 4358-4365 NN denotes pathway
T8107 4349-4357 NN denotes Nrf2-ARE
T8049 4051-4052 -RRB- denotes )
T8048 4046-4051 NN denotes MAPKs
T8047 4045-4046 -LRB- denotes (
T8046 4038-4044 NN denotes kinase
T8045 4030-4037 NN denotes protein
T8044 4012-4029 JJ denotes mitogen-activated
T8043 4003-4011 JJ denotes upstream
T8042 3999-4002 DT denotes the
T8041 3996-3998 IN denotes by
T8040 3986-3995 VB denotes regulated
T8039 3983-3985 VB denotes be
T8038 3979-3982 MD denotes may
T8037 3973-3978 WDT denotes which
T8036 3971-3972 -COMMA- denotes ,
T8035 3967-3971 NN denotes Nrf2
T8034 3963-3966 CC denotes and
T8033 3957-3962 NN denotes NF-κB
T8032 3949-3956 IN denotes between
T8031 3939-3948 NN denotes crosstalk
T8030 3928-3938 NN denotes complicate
T8029 3918-3927 JJ denotes potential
T8028 3914-3917 DT denotes the
T8027 3905-3913 VB denotes indicate
T8026 3896-3904 NN denotes findings
T8025 3890-3895 DT denotes these
T8024 3886-3889 PDT denotes All
T8023 3883-3884 -RRB- denotes ]
T8022 3881-3883 CD denotes 25
T8021 3880-3881 -LRB- denotes [
T8020 3864-3879 NN denotes hypoacetylation
T8019 3856-3863 NN denotes histone
T8018 3850-3855 JJ denotes local
T8017 3847-3849 CC denotes or
T8016 3843-3846 NN denotes CBP
T8015 3840-3842 IN denotes of
T8014 3833-3839 NN denotes domain
T8013 3825-3832 NN denotes CH1-KIX
T8012 3821-3824 DT denotes the
T8011 3816-3820 IN denotes with
T8010 3804-3815 NN denotes interaction
T8009 3792-3803 JJ denotes competitive
T8008 3789-3791 IN denotes by
T8007 3783-3788 NN denotes level
T8006 3767-3782 JJ denotes transcriptional
T8005 3764-3766 IN denotes at
T8004 3756-3763 NN denotes pathway
T8003 3747-3755 NN denotes Nrf2-ARE
T8002 3743-3746 DT denotes the
T8001 3733-3742 VB denotes repressed
T8000 3725-3732 NN denotes subunit
T7999 3721-3724 NN denotes p65
T7998 3715-3720 NN denotes NF-κB
T7997 3708-3713 NN denotes level
T7996 3692-3707 JJ denotes transcriptional
T7995 3689-3691 IN denotes at
T7994 3684-3688 NN denotes Nrf2
T7993 3676-3683 VB denotes inhibit
T7992 3672-3675 MD denotes can
T7991 3666-3671 NN denotes NF-κB
T7990 3661-3665 IN denotes that
T7989 3652-3660 VB denotes reported
T7988 3649-3651 VB denotes is
T7987 3646-3648 PRP denotes it
T7986 3644-3645 -COMMA- denotes ,
T7985 3631-3644 RB denotes Interestingly
T7984 3628-3629 -RRB- denotes ]
T7983 3626-3628 CD denotes 24
T7982 3625-3626 -LRB- denotes [
T7981 3618-3624 NN denotes sepsis
T7980 3605-3617 JJ denotes experimental
T7979 3599-3604 IN denotes after
T7978 3594-3598 NN denotes mice
T7977 3579-3593 JJ denotes Nrf2-deficient
T7976 3576-3578 IN denotes of
T7975 3564-3575 NN denotes fibroblasts
T7974 3554-3563 JJ denotes embryonic
T7973 3548-3553 NN denotes mouse
T7972 3544-3547 CC denotes and
T7971 3542-3543 -COMMA- denotes ,
T7970 3531-3542 NN denotes macrophages
T7969 3529-3530 -COMMA- denotes ,
T7968 3525-3529 NN denotes lung
T7967 3522-3524 IN denotes in
T7966 3511-3521 VB denotes discovered
T7965 3506-3510 RB denotes also
T7964 3503-3505 VB denotes is
T7963 3497-3502 NN denotes NF-κB
T7962 3494-3496 IN denotes of
T7961 3483-3493 NN denotes activation
T7960 3474-3482 VB denotes Enhanced
T7959 3466-3472 NN denotes injury
T7958 3458-3465 NN denotes scratch
T7957 3452-3457 IN denotes after
T7956 3441-3451 NN denotes astrocytes
T7955 3432-3440 VB denotes cultured
T7954 3429-3431 IN denotes in
T7953 3421-3428 VB denotes existed
T7952 3408-3420 NN denotes relationship
T7951 3403-3407 JJ denotes such
T7950 3393-3402 VB denotes confirmed
T7949 3385-3392 RB denotes further
T7948 3379-3384 NN denotes study
T7947 3374-3378 DT denotes this
T7946 3369-3373 IN denotes from
T7945 3361-3368 NN denotes Results
T7944 3358-3359 -RRB- denotes ]
T7943 3356-3358 CD denotes 23
T7942 3354-3355 -COMMA- denotes ,
T7941 3353-3354 CD denotes 5
T7940 3351-3352 -COMMA- denotes ,
T7939 3350-3351 CD denotes 4
T7938 3349-3350 -LRB- denotes [
T7937 3345-3348 NNP denotes TBI
T7936 3339-3344 IN denotes after
T7935 3329-3338 NN denotes intestine
T7934 3325-3328 CC denotes and
T7933 3323-3324 -COMMA- denotes ,
T7932 3318-3323 NN denotes brain
T7931 3316-3317 -COMMA- denotes ,
T7930 3312-3316 NN denotes lung
T7929 3309-3311 IN denotes in
T7928 3300-3308 NN denotes response
T7927 3287-3299 JJ denotes inflammatory
T7926 3283-3286 CC denotes and
T7925 3274-3282 NN denotes activity
T7924 3268-3273 NN denotes NF-κB
T7923 3265-3267 IN denotes of
T7922 3252-3264 NN denotes augmentation
T7921 3244-3251 VB denotes induces
T7920 3239-3243 NN denotes Nrf2
T7919 3236-3238 IN denotes of
T7918 3226-3235 NN denotes depletion
T7917 3221-3225 IN denotes that
T7916 3212-3220 VB denotes indicate
T7915 3204-3211 NN denotes studies
T7914 3195-3203 JJ denotes previous
T7913 3191-3194 PRP-DOLLAR- denotes our
T7912 3189-3190 -COMMA- denotes ,
T7911 3178-3189 RB denotes Furthermore
T7910 3175-3176 -RRB- denotes ]
T7909 3173-3175 CD denotes 22
T7908 3172-3173 -LRB- denotes [
T7907 3170-3171 -RRB- denotes )
T7906 3167-3170 NN denotes CUR
T7905 3166-3167 -LRB- denotes (
T7904 3157-3165 NN denotes curcumin
T7903 3153-3156 CC denotes and
T7902 3149-3152 NN denotes SFN
T7901 3146-3148 IN denotes as
T7900 3141-3145 JJ denotes such
T7899 3139-3140 -COMMA- denotes ,
T7898 3129-3139 NN denotes activators
T7897 3124-3128 NN denotes Nrf2
T7896 3116-3123 JJ denotes diverse
T7895 3113-3115 IN denotes by
T7894 3102-3112 VB denotes attenuated
T7893 3099-3101 VB denotes be
T7892 3093-3098 MD denotes could
T7891 3091-3092 -RRB- denotes )
T7890 3088-3091 NN denotes LPS
T7889 3087-3088 -LRB- denotes (
T7888 3068-3086 NN denotes lipopolysaccharide
T7887 3065-3067 IN denotes by
T7886 3057-3064 VB denotes induced
T7885 3046-3056 NN denotes activation
T7884 3040-3045 NN denotes NF-κB
T7883 3036-3039 CC denotes And
T7882 3033-3034 -RRB- denotes ]
T7881 3031-3033 CD denotes 21
T7880 3030-3031 -LRB- denotes [
T7879 3020-3029 NN denotes signaling
T7878 3014-3019 NN denotes NF-κB
T7877 3002-3013 VB denotes alleviating
T7876 2989-3001 RB denotes consequently
T7875 2987-2988 -COMMA- denotes ,
T7874 2974-2987 NN denotes translocation
T7873 2966-2973 JJ denotes nuclear
T7872 2958-2965 NN denotes subunit
T7871 2952-2957 NN denotes NF-κB
T7870 2948-2951 NN denotes p65
T7869 2944-2947 CC denotes and
T7868 2928-2943 NN denotes phosphorylation
T7867 2920-2927 NN denotes IKK/IκB
T7866 2912-2919 VB denotes inhibit
T7865 2909-2911 TO denotes to
T7864 2904-2908 JJ denotes able
T7863 2901-2903 VB denotes be
T7862 2898-2900 TO denotes to
T7861 2892-2897 VB denotes found
T7860 2889-2891 VB denotes is
T7859 2885-2888 NN denotes SFN
T7858 2882-2884 IN denotes of
T7857 2867-2881 NN denotes Administration
T7856 2856-2865 NN denotes signaling
T7855 2850-2855 NN denotes NF-κB
T7854 2847-2849 IN denotes by
T7853 2838-2846 VB denotes mediated
T7852 2834-2837 VB denotes are
T7851 2828-2833 WDT denotes which
T7850 2819-2827 NN denotes pathways
T7849 2803-2818 JJ denotes proinflammatory
T7848 2800-2802 IN denotes of
T7847 2788-2799 NN denotes suppression
T7846 2785-2787 IN denotes by
T7845 2776-2784 VB denotes achieved
T7844 2773-2775 VB denotes be
T7843 2769-2772 MD denotes may
T7842 2764-2768 NN denotes Nrf2
T7841 2761-2763 IN denotes of
T7840 2754-2760 NN denotes effect
T7839 2742-2753 JJ denotes antioxidant
T7838 2737-2741 IN denotes that
T7837 2725-2736 NN denotes possibility
T7836 2721-2724 DT denotes the
T7835 2713-2720 VB denotes suggest
T7834 2705-2712 NN denotes studies
T7731 2112-2113 -LRB- denotes (
T7730 2095-2111 JJ denotes 4-Hydroxynonenal
T7729 2091-2094 IN denotes for
T7728 2074-2090 NN denotes immunoreactivity
T7727 2070-2073 DT denotes the
T7726 2060-2069 VB denotes decreases
T7725 2056-2059 CC denotes and
T7724 2052-2055 NN denotes rat
T7723 2049-2051 IN denotes of
T7722 2042-2048 NN denotes memory
T7721 2034-2041 JJ denotes spatial
T7720 2025-2033 VB denotes improves
T7719 2011-2024 RB denotes significantly
T7718 2009-2010 -COMMA- denotes ,
T7717 2005-2009 NN denotes Nrf2
T7716 2002-2004 IN denotes of
T7715 1994-2001 NN denotes inducer
T7714 1991-1993 DT denotes an
T7713 1989-1990 -COMMA- denotes ,
T7712 1986-1989 NNP denotes SFN
T7711 1983-1985 IN denotes of
T7710 1968-1982 NN denotes administration
T7709 1957-1967 NN denotes Postinjury
T7708 1954-1955 -RRB- denotes ]
T7707 1952-1954 CD denotes 18
T7706 1951-1952 -LRB- denotes [
T7705 1945-1950 NN denotes brain
T7704 1942-1944 IN denotes in
T7703 1935-1941 NN denotes damage
T7702 1931-1934 DT denotes the
T7701 1924-1930 VB denotes reduce
T7700 1911-1923 RB denotes subsequently
T7699 1905-1910 MD denotes would
T7698 1899-1904 WDT denotes which
T7697 1897-1898 -COMMA- denotes ,
T7696 1896-1897 -RRB- denotes )
T7695 1892-1896 NN denotes NQO1
T7694 1891-1892 -LRB- denotes (
T7693 1874-1890 NN denotes oxidoreductase-1
T7692 1866-1873 NN denotes quinone
T7691 1864-1865 -COLON- denotes :
T7690 1863-1864 NN denotes H
T7689 1862-1863 -RRB- denotes )
T7688 1861-1862 NN denotes P
T7687 1860-1861 -LRB- denotes (
T7686 1856-1859 NN denotes NAD
T7685 1852-1855 CC denotes and
T7684 1850-1851 -RRB- denotes )
T7683 1846-1850 NN denotes HO-1
T7682 1845-1846 -LRB- denotes (
T7681 1833-1844 NN denotes oxygenase-1
T7680 1828-1832 NN denotes heme
T7679 1825-1827 IN denotes as
T7678 1820-1824 JJ denotes such
T7677 1818-1819 -COMMA- denotes ,
T7676 1813-1818 NN denotes genes
T7675 1801-1812 JJ denotes antioxidant
T7674 1798-1800 IN denotes of
T7673 1792-1797 NN denotes group
T7672 1790-1791 DT denotes a
T7671 1787-1789 IN denotes of
T7670 1773-1786 NN denotes transcription
T7669 1763-1772 VB denotes activates
T7668 1758-1762 NN denotes Nrf2
T7667 1755-1757 IN denotes of
T7666 1749-1754 NN denotes level
T7665 1740-1748 VB denotes Enhanced
T7664 1737-1738 -RRB- denotes ]
T7663 1735-1737 CD denotes 17
T7662 1734-1735 -LRB- denotes [
T7661 1730-1733 NNP denotes TBI
T7660 1724-1729 IN denotes after
T7659 1717-1723 NN denotes tissue
T7658 1711-1716 NN denotes brain
T7657 1708-1710 IN denotes in
T7656 1703-1707 NN denotes Nrf2
T7655 1700-1702 IN denotes of
T7654 1687-1699 NN denotes augmentation
T7653 1683-1686 DT denotes the
T7652 1676-1682 VB denotes proved
T7651 1672-1675 VB denotes has
T7650 1666-1671 NN denotes study
T7649 1657-1665 JJ denotes previous
T7648 1653-1656 PRP-DOLLAR- denotes Our
T7647 1648-1651 NNP denotes TBI
T7646 1645-1647 IN denotes in
T7645 1636-1644 VB denotes involved
T7644 1632-1635 DT denotes all
T7643 1628-1631 VB denotes are
T7642 1622-1627 WDT denotes which
T7641 1620-1621 -COMMA- denotes ,
T7640 1609-1620 NN denotes metabolites
T7639 1603-1608 JJ denotes toxic
T7638 1600-1602 IN denotes of
T7637 1587-1599 NN denotes accumulation
T7636 1583-1586 CC denotes and
T7635 1581-1582 -COMMA- denotes ,
T7634 1575-1581 NN denotes damage
T7633 1562-1574 JJ denotes inflammatory
T7632 1560-1561 -COMMA- denotes ,
T7631 1554-1560 NN denotes stress
T7630 1544-1553 JJ denotes oxidative
T7629 1535-1543 VB denotes reducing
T7628 1532-1534 IN denotes in
T7627 1522-1531 NN denotes regulator
T7626 1518-1521 JJ denotes key
T7625 1514-1517 DT denotes the
T7624 1511-1513 VB denotes be
T7623 1508-1510 TO denotes to
T7622 1501-1507 VB denotes proved
T7621 1496-1500 VB denotes been
T7620 1492-1495 VB denotes has
T7619 1484-1491 NN denotes pathway
T7618 1475-1483 NN denotes Nrf2-ARE
T7617 1470-1473 NN denotes TBI
T7616 1464-1469 IN denotes after
T7615 1459-1463 NN denotes loop
T7614 1444-1458 JJ denotes autoregulatory
T7613 1439-1443 JJ denotes such
T7612 1431-1438 VB denotes prevent
T7611 1428-1430 TO denotes to
T7610 1421-1427 NN denotes factor
T7609 1412-1420 JJ denotes upstream
T7608 1409-1411 DT denotes an
T7607 1406-1408 IN denotes on
T7606 1396-1405 VB denotes targeting
T7605 1392-1395 IN denotes for
T7604 1385-1391 NN denotes choice
T7603 1380-1384 JJ denotes good
T7602 1378-1379 DT denotes a
T7601 1375-1377 VB denotes is
T7600 1372-1374 PRP denotes It
T7599 1365-1370 NN denotes brain
T7598 1362-1364 TO denotes to
T7597 1355-1361 NN denotes injury
T7596 1345-1354 JJ denotes secondary
T7595 1337-1344 VB denotes induces
T7594 1333-1336 CC denotes and
T7593 1320-1332 NN denotes inflammation
T7592 1317-1319 IN denotes of
T7591 1310-1316 NN denotes effect
T7590 1301-1309 JJ denotes damaging
T7589 1297-1300 DT denotes the
T7588 1286-1296 VB denotes aggravates
T7587 1276-1285 RB denotes extremely
T7586 1271-1275 NN denotes loop
T7585 1256-1270 JJ denotes autoregulatory
T7584 1251-1255 DT denotes This
T7583 1248-1249 -RRB- denotes ]
T7582 1246-1248 CD denotes 16
T7581 1244-1245 -COMMA- denotes ,
T7580 1242-1244 CD denotes 15
T7579 1241-1242 -LRB- denotes [
T7578 1235-1240 NN denotes NF-κB
T7577 1232-1234 IN denotes of
T7576 1221-1231 NN denotes activation
T7575 1214-1220 VB denotes induce
T7574 1210-1213 MD denotes can
T7573 1205-1209 RB denotes also
T7572 1199-1204 NN denotes IL-1β
T7571 1195-1198 CC denotes and
T7570 1189-1194 NN denotes TNF-α
T7569 1185-1188 CC denotes and
T7568 1183-1184 -COMMA- denotes ,
T7567 1182-1183 -RRB- denotes ]
T7566 1180-1182 CD denotes 14
T7565 1179-1180 -LRB- denotes [
T7564 1173-1178 NN denotes cells
T7563 1163-1172 NN denotes carcinoma
T7562 1157-1162 NN denotes colon
T7561 1151-1156 JJ denotes human
T7560 1148-1150 IN denotes in
T7559 1143-1147 NN denotes MMP9
T7558 1140-1142 IN denotes of
T7557 1125-1139 NN denotes overexpression
T7556 1117-1124 VB denotes induces
T7555 1112-1116 NN denotes IL-6
T7554 1108-1111 CC denotes and
T7553 1106-1107 -COMMA- denotes ,
T7552 1105-1106 -RRB- denotes ]
T7551 1103-1105 CD denotes 13
T7550 1101-1102 -COMMA- denotes ,
T7549 1099-1101 CD denotes 12
T7548 1098-1099 -LRB- denotes [
T7547 1087-1097 NN denotes astrocytes
T7546 1084-1086 IN denotes in
T7545 1079-1083 NN denotes MMP9
T7544 1075-1078 IN denotes for
T7543 1063-1074 NN denotes stimulators
T7542 1056-1062 JJ denotes potent
T8106 4346-4348 IN denotes of
T8105 4335-4345 NN denotes activation
T8104 4332-4334 IN denotes in
T8103 4326-4331 NN denotes cells
T8102 4315-4325 NN denotes respondent
T8101 4312-4314 IN denotes of
T8100 4307-4311 NN denotes kind
T8099 4303-4306 CD denotes one
T8098 4300-4302 VB denotes be
T8097 4296-4299 MD denotes may
T8096 4285-4295 NN denotes astrocytes
T8095 4280-4284 IN denotes that
T8094 4271-4279 VB denotes reasoned
T8093 4268-4270 VB denotes be
T8092 4264-4267 MD denotes can
T8091 4261-4263 PRP denotes it
T8090 4259-4260 -COMMA- denotes ,
T8089 4252-4259 NN denotes nucleus
T8088 4249-4251 IN denotes in
T8087 4242-4248 RB denotes mainly
T8086 4233-4241 NN denotes function
T8085 4228-4232 VB denotes take
T8084 4221-4227 MD denotes should
T8083 4215-4220 WDT denotes which
T8082 4208-4214 NN denotes factor
T8081 4194-4207 NN denotes transcription
T8080 4192-4193 DT denotes a
T8079 4189-4191 VB denotes is
T8078 4184-4188 NN denotes Nrf2
T8077 4179-4183 IN denotes that
T8076 4174-4178 NN denotes fact
T8075 4170-4173 DT denotes the
T8074 4167-4169 IN denotes of
T8073 4162-4166 NN denotes view
T8072 4159-4161 IN denotes In
T8071 4156-4157 -RRB- denotes ]
T8070 4154-4156 CD denotes 18
T8069 4153-4154 -LRB- denotes [
T8068 4149-4152 NNP denotes TBI
T8067 4143-4148 IN denotes after
T8066 4132-4142 NN denotes astrocytes
T8065 4129-4131 IN denotes of
T8064 4121-4128 NN denotes nucleus
T8063 4118-4120 IN denotes in
T8062 4109-4117 VB denotes detected
T8061 4102-4108 RB denotes mainly
T8060 4099-4101 VB denotes is
T8059 4094-4098 NN denotes Nrf2
T8058 4089-4093 IN denotes that
T8057 4079-4088 VB denotes confirmed
T8056 4074-4078 VB denotes been
T8055 4070-4073 VB denotes has
T8054 4067-4069 PRP denotes It
T8053 4064-4065 -RRB- denotes ]
T8052 4062-4064 CD denotes 26
T8051 4061-4062 -LRB- denotes [
T8050 4053-4060 NN denotes pathway
T7541 1052-1055 VB denotes are
T7540 1046-1051 NN denotes IL-1β
T7539 1042-1045 CC denotes and
T7538 1036-1041 NN denotes TNF-α
T7537 1034-1035 -COMMA- denotes ,
T7536 1027-1034 NN denotes example
T7535 1023-1026 IN denotes For
T7534 1012-1021 NN denotes mediators
T7533 996-1011 JJ denotes proinflammatory
T7532 990-995 DT denotes these
T7531 984-989 IN denotes among
T7530 979-983 NN denotes loop
T7529 964-978 JJ denotes autoregulatory
T7528 961-963 DT denotes an
T7527 958-960 VB denotes is
T7526 952-957 EX denotes there
T7525 947-951 IN denotes that
T7524 934-946 VB denotes demonstrated
T7523 929-933 VB denotes been
T7522 925-928 VB denotes has
T7521 922-924 PRP denotes It
T7520 910-920 NN denotes astrocytes
T7519 901-909 VB denotes cultured
T7518 898-900 IN denotes in
T7517 892-897 IN denotes above
T7516 882-891 VB denotes mentioned
T7410 278-288 NN denotes expression
T7409 269-277 VB denotes enhanced
T7408 265-268 CC denotes and
T7407 259-264 NN denotes NF-κB
T7406 256-258 IN denotes of
T7405 247-255 NN denotes activity
T7404 240-246 JJ denotes higher
T7403 232-239 VB denotes induced
T7402 225-231 NN denotes injury
T7401 217-224 NN denotes scratch
T7400 212-216 IN denotes that
T7399 203-211 VB denotes revealed
T7398 200-202 PRP denotes we
T7397 195-199 RB denotes Also
T7396 183-193 NN denotes astrocytes
T7395 174-182 VB denotes cultured
T7394 171-173 IN denotes in
T7393 166-170 NN denotes MMP9
T7392 162-165 CC denotes and
T7391 160-161 -COMMA- denotes ,
T7390 156-160 NN denotes IL-6
T7389 154-155 -COMMA- denotes ,
T7388 149-154 NN denotes IL-1β
T7387 147-148 -COMMA- denotes ,
T7386 142-147 NN denotes TNF-α
T7385 139-141 IN denotes of
T7384 124-138 NN denotes overexpression
T7383 120-123 CC denotes and
T7382 111-119 NN denotes activity
T7381 103-110 NN denotes binding
T7380 99-102 NN denotes DNA
T7379 93-98 NN denotes NF-κB
T7378 90-92 IN denotes of
T7377 77-89 NN denotes upregulation
T7376 73-76 DT denotes the
T7375 65-72 VB denotes induced
T7374 58-64 NN denotes injury
T7373 50-57 NN denotes scratch
T7372 45-49 IN denotes that
T7371 32-44 VB denotes demonstrated
T7370 26-31 NN denotes study
T7369 18-25 JJ denotes present
T7368 14-17 DT denotes The
T7833 2698-2704 JJ denotes animal
T7832 2693-2697 IN denotes from
T7831 2684-2692 VB denotes obtained
T7830 2679-2683 NN denotes Data
T7829 2671-2677 NN denotes deaths
T7828 2660-2670 NN denotes astrocytes
T7827 2655-2659 JJ denotes more
T7826 2652-2654 TO denotes to
T7825 2648-2651 VB denotes led
T7824 2638-2647 NN denotes mediators
T7823 2622-2637 JJ denotes proinflammatory
T7822 2616-2621 DT denotes these
T7821 2613-2615 IN denotes of
T7820 2598-2612 NN denotes overexpression
T7819 2594-2597 CC denotes and
T7818 2592-2593 -COMMA- denotes ,
T7817 2588-2592 NN denotes time
T7816 2582-2587 JJ denotes first
T7815 2578-2581 DT denotes the
T7814 2574-2577 IN denotes for
T7813 2562-2573 NN denotes astrocyetes
T7812 2553-2561 JJ denotes wildtype
T7811 2550-2552 IN denotes in
T7810 2545-2549 IN denotes than
T7809 2534-2544 NN denotes astrocytes
T7808 2525-2533 NN denotes knockout
T7807 2520-2524 NN denotes Nrf2
T7806 2511-2519 VB denotes cultured
T7805 2508-2510 IN denotes in
T7804 2497-2507 VB denotes aggravated
T7803 2492-2496 RB denotes more
T7802 2488-2491 VB denotes was
T7801 2481-2487 NN denotes injury
T7800 2473-2480 NN denotes scratch
T7799 2467-2472 IN denotes after
T7798 2462-2466 NN denotes MMP9
T7797 2458-2461 CC denotes and
T7796 2456-2457 -COMMA- denotes ,
T7795 2452-2456 NN denotes IL-6
T7794 2450-2451 -COMMA- denotes ,
T7793 2445-2450 NN denotes IL-1β
T7792 2443-2444 -COMMA- denotes ,
T7791 2438-2443 NN denotes TNF-α
T7790 2435-2437 IN denotes of
T7789 2420-2434 NN denotes overexpression
T7788 2415-2419 IN denotes that
T7787 2406-2414 VB denotes revealed
T7786 2398-2405 NN denotes results
T7785 2394-2397 PRP-DOLLAR- denotes our
T7784 2392-2393 -COMMA- denotes ,
T7783 2388-2392 RB denotes Here
T7782 2385-2386 -RRB- denotes ]
T7781 2383-2385 CD denotes 20
T7780 2382-2383 -LRB- denotes [
T7779 2378-2381 NNP denotes TBI
T7778 2372-2377 IN denotes after
T7777 2366-2371 NN denotes brain
T7776 2363-2365 IN denotes in
T7775 2353-2362 NN denotes mediators
T7774 2337-2352 JJ denotes proinflammatory
T7773 2334-2336 IN denotes of
T7772 2323-2333 NN denotes expression
T7771 2316-2322 JJ denotes higher
T7770 2308-2315 VB denotes induces
T7769 2303-2307 NN denotes Nrf2
T7768 2300-2302 IN denotes of
T7767 2290-2299 NN denotes Depletion
T7766 2285-2288 NNP denotes TBI
T7765 2282-2284 TO denotes to
T7764 2270-2281 JJ denotes susceptible
T7763 2265-2269 RB denotes more
T7762 2258-2264 VB denotes appear
T7761 2253-2257 NN denotes mice
T7760 2238-2252 JJ denotes Nrf2-deficient
T7759 2236-2237 -COMMA- denotes ,
T7758 2232-2236 NN denotes hand
T7757 2226-2231 JJ denotes other
T7756 2222-2225 DT denotes the
T7755 2219-2221 IN denotes On
T7754 2216-2217 -RRB- denotes ]
T7753 2214-2216 CD denotes 19
T7752 2213-2214 -LRB- denotes [
T7751 2209-2212 NNP denotes TBI
T7750 2203-2208 IN denotes after
T7749 2191-2202 NN denotes hippocampus
T7748 2188-2190 IN denotes of
T7747 2179-2187 NN denotes subfield
T7746 2175-2178 NN denotes CA3
T7745 2171-2174 DT denotes the
T7744 2167-2170 CC denotes and
T7743 2160-2166 NN denotes cortex
T7742 2156-2159 DT denotes the
T7741 2153-2155 IN denotes in
T7740 2151-2152 -COMMA- denotes ,
T7739 2139-2151 NN denotes peroxidation
T7738 2133-2138 NN denotes lipid
T7737 2130-2132 IN denotes of
T7736 2123-2129 NN denotes marker
T7735 2121-2122 DT denotes a
T7734 2119-2120 -COMMA- denotes ,
T7733 2118-2119 -RRB- denotes )
T7732 2113-2118 NN denotes 4-HNE
T7515 872-881 NN denotes mediators
T7514 856-871 JJ denotes proinflammatory
T7513 852-855 CC denotes and
T7512 850-851 -COMMA- denotes ,
T7511 846-850 NN denotes MMP9
T7510 843-845 IN denotes of
T7509 828-842 NN denotes overexpression
T7508 826-827 -COMMA- denotes ,
T7507 818-826 NN denotes activity
T7506 810-817 NN denotes binding
T7505 806-809 NN denotes DNA
T7504 800-805 NN denotes NF-κB
T7503 797-799 IN denotes of
T7502 787-796 NN denotes elevation
T7501 779-786 VB denotes induced
T7500 772-778 NN denotes injury
T7499 764-771 NN denotes scratch
T7498 759-763 IN denotes that
T7497 750-758 VB denotes revealed
T7496 745-749 RB denotes also
T7495 737-744 NN denotes results
T7494 733-736 PRP-DOLLAR- denotes Our
T7493 730-731 -RRB- denotes ]
T7492 728-730 CD denotes 11
T7491 726-727 -COMMA- denotes ,
T7490 724-726 CD denotes 10
T7489 722-723 -COMMA- denotes ,
T7488 721-722 CD denotes 3
T7487 720-721 -LRB- denotes [
T7486 716-719 NNP denotes TBI
T7485 710-715 IN denotes after
T7484 702-709 NN denotes tissues
T7483 696-701 NN denotes brain
T7482 693-695 IN denotes in
T7481 691-692 -COMMA- denotes ,
T7480 687-691 NN denotes IL-6
T7479 683-686 CC denotes and
T7478 681-682 -COMMA- denotes ,
T7477 676-681 NN denotes IL-1β
T7476 674-675 -COMMA- denotes ,
T7475 669-674 NN denotes TNF-α
T7474 659-668 VB denotes including
T7473 657-658 -COMMA- denotes ,
T7472 648-657 NN denotes cytokines
T7471 632-647 JJ denotes proinflammatory
T7470 629-631 IN denotes of
T7469 621-628 NN denotes battery
T7468 619-620 DT denotes a
T7467 615-618 CC denotes and
T7466 610-614 NN denotes MMP9
T7465 607-609 IN denotes of
T7464 593-606 NN denotes transcription
T7463 585-592 VB denotes induces
T7462 581-584 CC denotes and
T7461 571-580 VB denotes activated
T7460 567-570 VB denotes was
T7459 564-566 PRP denotes it
T7458 559-563 IN denotes once
T7457 555-558 NN denotes DNA
T7456 550-554 IN denotes with
T7455 544-549 VB denotes binds
T7454 538-543 NN denotes NF-κB
T7453 536-537 -COMMA- denotes ,
T7452 530-536 NN denotes factor
T7451 519-529 NN denotes transcript
T7450 517-518 DT denotes a
T7449 514-516 IN denotes As
T7448 511-512 -RRB- denotes ]
T7447 510-511 CD denotes 9
T7446 508-509 -COMMA- denotes ,
T7445 507-508 CD denotes 2
T7444 506-507 -LRB- denotes [
T7443 499-505 NN denotes injury
T7442 489-498 JJ denotes traumatic
T7441 483-488 IN denotes after
T7440 478-482 NN denotes cord
T7439 471-477 JJ denotes spinal
T7438 467-470 CC denotes and
T7437 461-466 NN denotes brain
T7436 458-460 IN denotes in
T7435 448-457 VB denotes activated
T7434 445-447 VB denotes is
T7433 439-444 NN denotes NF-κB
T7432 434-438 IN denotes that
T7431 421-433 VB denotes demonstrated
T7430 416-420 VB denotes been
T7429 412-415 VB denotes has
T7428 409-411 PRP denotes It
T7427 403-407 NN denotes time
T7426 397-402 JJ denotes first
T7425 393-396 DT denotes the
T7424 389-392 IN denotes for
T7423 378-388 NN denotes astrocytes
T7422 369-377 JJ denotes wildtype
T7421 366-368 IN denotes in
T7420 360-365 DT denotes those
T7419 355-359 IN denotes than
T7418 344-354 NN denotes astrocytes
T7417 335-343 VB denotes cultured
T7416 326-334 NN denotes knockout
T7415 321-325 NN denotes Nrf2
T7414 318-320 IN denotes in
T7413 308-317 NN denotes cytokines
T7412 292-307 JJ denotes proinflammatory
T7411 289-291 IN denotes of
R5909 T7370 T7368 arg1Of study,The
R5910 T7370 T7369 arg1Of study,present
R5911 T7370 T7371 arg1Of study,demonstrated
R5912 T7374 T7373 arg1Of injury,scratch
R5913 T7374 T7375 arg1Of injury,induced
R5914 T7375 T7371 arg2Of induced,demonstrated
R5915 T7375 T7372 arg1Of induced,that
R5916 T7377 T7376 arg1Of upregulation,the
R5917 T7377 T7378 arg1Of upregulation,of
R5918 T7377 T7383 arg1Of upregulation,and
R5919 T7382 T7378 arg2Of activity,of
R5920 T7382 T7379 arg1Of activity,NF-κB
R5921 T7382 T7380 arg1Of activity,DNA
R5922 T7382 T7381 arg1Of activity,binding
R5923 T7383 T7375 arg2Of and,induced
R5924 T7384 T7383 arg2Of overexpression,and
R5925 T7384 T7385 arg1Of overexpression,of
R5926 T7386 T7387 arg1Of TNF-α,","
R5927 T7387 T7389 arg1Of ",",","
R5928 T7388 T7387 arg2Of IL-1β,","
R5929 T7389 T7392 arg1Of ",",and
R5930 T7390 T7389 arg2Of IL-6,","
R5931 T7392 T7385 arg2Of and,of
R5932 T7392 T7391 arg1Of and,","
R5933 T7392 T7394 arg1Of and,in
R5934 T7393 T7392 arg2Of MMP9,and
R5935 T7396 T7394 arg2Of astrocytes,in
R5936 T7396 T7395 arg2Of astrocytes,cultured
R5937 T7398 T7399 arg1Of we,revealed
R5938 T7399 T7397 arg1Of revealed,Also
R5939 T7402 T7401 arg1Of injury,scratch
R5940 T7402 T7403 arg1Of injury,induced
R5941 T7403 T7399 arg2Of induced,revealed
R5942 T7403 T7400 arg1Of induced,that
R5943 T7405 T7404 arg1Of activity,higher
R5944 T7405 T7406 arg1Of activity,of
R5945 T7405 T7408 arg1Of activity,and
R5946 T7407 T7406 arg2Of NF-κB,of
R5947 T7408 T7403 arg2Of and,induced
R5948 T7410 T7408 arg2Of expression,and
R5949 T7410 T7409 arg2Of expression,enhanced
R5950 T7410 T7411 arg1Of expression,of
R5951 T7410 T7414 arg1Of expression,in
R5952 T7413 T7411 arg2Of cytokines,of
R5953 T7413 T7412 arg1Of cytokines,proinflammatory
R5954 T7418 T7414 arg2Of astrocytes,in
R5955 T7418 T7415 arg1Of astrocytes,Nrf2
R5956 T7418 T7416 arg1Of astrocytes,knockout
R5957 T7418 T7417 arg2Of astrocytes,cultured
R5958 T7418 T7419 arg1Of astrocytes,than
R5959 T7420 T7419 arg2Of those,than
R5960 T7420 T7421 arg1Of those,in
R5961 T7423 T7421 arg2Of astrocytes,in
R5962 T7423 T7422 arg1Of astrocytes,wildtype
R5963 T7423 T7424 arg1Of astrocytes,for
R5964 T7427 T7424 arg2Of time,for
R5965 T7427 T7425 arg1Of time,the
R5966 T7427 T7426 arg1Of time,first
R5967 T7428 T7429 arg1Of It,has
R5968 T7428 T7430 arg1Of It,been
R5969 T7428 T7431 arg2Of It,demonstrated
R5970 T7431 T7429 arg2Of demonstrated,has
R5971 T7431 T7430 arg2Of demonstrated,been
R5972 T7433 T7434 arg1Of NF-κB,is
R5973 T7433 T7435 arg2Of NF-κB,activated
R5974 T7435 T7431 arg3Of activated,demonstrated
R5975 T7435 T7432 arg1Of activated,that
R5976 T7435 T7434 arg2Of activated,is
R5977 T7435 T7436 arg1Of activated,in
R5978 T7435 T7441 arg1Of activated,after
R5979 T7435 T7444 arg1Of activated,[
R5980 T7437 T7438 arg1Of brain,and
R5981 T7438 T7436 arg2Of and,in
R5982 T7440 T7438 arg2Of cord,and
R5983 T7440 T7439 arg1Of cord,spinal
R5984 T7443 T7441 arg2Of injury,after
R5985 T7443 T7442 arg1Of injury,traumatic
R5986 T7445 T7444 arg2Of 2,[
R5987 T7445 T7446 arg1Of 2,","
R5988 T7447 T7446 arg2Of 9,","
R5989 T7448 T7444 arg3Of ],[
R5990 T7452 T7449 arg2Of factor,As
R5991 T7452 T7450 arg1Of factor,a
R5992 T7452 T7451 arg1Of factor,transcript
R5993 T7454 T7455 arg1Of NF-κB,binds
R5994 T7454 T7463 arg1Of NF-κB,induces
R5995 T7455 T7456 arg1Of binds,with
R5996 T7455 T7458 arg1Of binds,once
R5997 T7455 T7462 arg1Of binds,and
R5998 T7457 T7456 arg2Of DNA,with
R5999 T7459 T7460 arg1Of it,was
R6000 T7459 T7461 arg2Of it,activated
R6001 T7461 T7458 arg2Of activated,once
R6002 T7461 T7460 arg2Of activated,was
R6003 T7462 T7449 arg1Of and,As
R6004 T7462 T7453 arg1Of and,","
R6005 T7463 T7462 arg2Of induces,and
R6006 T7464 T7463 arg2Of transcription,induces
R6007 T7464 T7465 arg1Of transcription,of
R6008 T7464 T7470 arg1Of transcription,of
R6009 T7466 T7467 arg1Of MMP9,and
R6010 T7467 T7465 arg2Of and,of
R6011 T7469 T7467 arg2Of battery,and
R6012 T7469 T7468 arg1Of battery,a
R6013 T7472 T7470 arg2Of cytokines,of
R6014 T7472 T7471 arg1Of cytokines,proinflammatory
R6015 T7472 T7473 arg1Of cytokines,","
R6016 T7472 T7474 arg1Of cytokines,including
R6017 T7475 T7476 arg1Of TNF-α,","
R6018 T7476 T7479 arg1Of ",",and
R6019 T7477 T7476 arg2Of IL-1β,","
R6020 T7479 T7474 arg2Of and,including
R6021 T7479 T7478 arg1Of and,","
R6022 T7479 T7481 arg1Of and,","
R6023 T7479 T7482 arg1Of and,in
R6024 T7479 T7485 arg1Of and,after
R6025 T7480 T7479 arg2Of IL-6,and
R6026 T7484 T7482 arg2Of tissues,in
R6027 T7484 T7483 arg1Of tissues,brain
R6028 T7486 T7485 arg2Of TBI,after
R6029 T7486 T7487 arg1Of TBI,[
R6030 T7488 T7489 arg1Of 3,","
R6031 T7489 T7487 arg2Of ",",[
R6032 T7489 T7491 arg1Of ",",","
R6033 T7490 T7489 arg2Of 10,","
R6034 T7492 T7491 arg2Of 11,","
R6035 T7493 T7487 arg3Of ],[
R6036 T7495 T7494 arg1Of results,Our
R6037 T7495 T7497 arg1Of results,revealed
R6038 T7497 T7496 arg1Of revealed,also
R6039 T7500 T7499 arg1Of injury,scratch
R6040 T7500 T7501 arg1Of injury,induced
R6041 T7501 T7497 arg2Of induced,revealed
R6042 T7501 T7498 arg1Of induced,that
R6043 T7502 T7501 arg2Of elevation,induced
R6044 T7502 T7503 arg1Of elevation,of
R6045 T7507 T7504 arg1Of activity,NF-κB
R6046 T7507 T7505 arg1Of activity,DNA
R6047 T7507 T7506 arg1Of activity,binding
R6048 T7507 T7508 arg1Of activity,","
R6049 T7508 T7513 arg1Of ",",and
R6050 T7509 T7508 arg2Of overexpression,","
R6051 T7509 T7510 arg1Of overexpression,of
R6052 T7511 T7510 arg2Of MMP9,of
R6053 T7513 T7503 arg2Of and,of
R6054 T7513 T7512 arg1Of and,","
R6055 T7515 T7513 arg2Of mediators,and
R6056 T7515 T7514 arg1Of mediators,proinflammatory
R6057 T7515 T7516 arg2Of mediators,mentioned
R6058 T7516 T7517 arg1Of mentioned,above
R6059 T7516 T7518 arg1Of mentioned,in
R6060 T7520 T7518 arg2Of astrocytes,in
R6061 T7520 T7519 arg2Of astrocytes,cultured
R6062 T7521 T7522 arg1Of It,has
R6063 T7521 T7523 arg1Of It,been
R6064 T7521 T7524 arg2Of It,demonstrated
R6065 T7524 T7522 arg2Of demonstrated,has
R6066 T7524 T7523 arg2Of demonstrated,been
R6067 T7526 T7527 arg1Of there,is
R6068 T7527 T7524 arg3Of is,demonstrated
R6069 T7527 T7525 arg1Of is,that
R6070 T7530 T7527 arg2Of loop,is
R6071 T7530 T7528 arg1Of loop,an
R6072 T7530 T7529 arg1Of loop,autoregulatory
R6073 T7530 T7531 arg1Of loop,among
R6074 T7534 T7531 arg2Of mediators,among
R6075 T7534 T7532 arg1Of mediators,these
R6076 T7534 T7533 arg1Of mediators,proinflammatory
R6077 T7536 T7535 arg2Of example,For
R6078 T7538 T7539 arg1Of TNF-α,and
R6079 T7539 T7541 arg1Of and,are
R6080 T7540 T7539 arg2Of IL-1β,and
R6081 T7541 T7554 arg1Of are,and
R6082 T7543 T7541 arg2Of stimulators,are
R6083 T7543 T7542 arg1Of stimulators,potent
R6084 T7543 T7544 arg1Of stimulators,for
R6085 T7543 T7546 arg1Of stimulators,in
R6086 T7545 T7544 arg2Of MMP9,for
R6087 T7547 T7546 arg2Of astrocytes,in
R6088 T7547 T7548 arg1Of astrocytes,[
R6089 T7549 T7550 arg1Of 12,","
R6090 T7550 T7548 arg2Of ",",[
R6091 T7551 T7550 arg2Of 13,","
R6092 T7552 T7548 arg3Of ],[
R6093 T7554 T7535 arg1Of and,For
R6094 T7554 T7537 arg1Of and,","
R6095 T7554 T7553 arg1Of and,","
R6096 T7555 T7556 arg1Of IL-6,induces
R6097 T7556 T7560 arg1Of induces,in
R6098 T7556 T7569 arg1Of induces,and
R6099 T7557 T7556 arg2Of overexpression,induces
R6100 T7557 T7558 arg1Of overexpression,of
R6101 T7559 T7558 arg2Of MMP9,of
R6102 T7564 T7560 arg2Of cells,in
R6103 T7564 T7561 arg1Of cells,human
R6104 T7564 T7562 arg1Of cells,colon
R6105 T7564 T7563 arg1Of cells,carcinoma
R6106 T7564 T7565 arg1Of cells,[
R6107 T7566 T7565 arg2Of 14,[
R6108 T7567 T7565 arg3Of ],[
R6109 T7569 T7554 arg2Of and,and
R6110 T7569 T7568 arg1Of and,","
R6111 T7570 T7571 arg1Of TNF-α,and
R6112 T7571 T7574 arg1Of and,can
R6113 T7571 T7575 arg1Of and,induce
R6114 T7572 T7571 arg2Of IL-1β,and
R6115 T7575 T7569 arg2Of induce,and
R6116 T7575 T7573 arg1Of induce,also
R6117 T7575 T7574 arg2Of induce,can
R6118 T7575 T7579 arg1Of induce,[
R6119 T7576 T7575 arg2Of activation,induce
R6120 T7576 T7577 arg1Of activation,of
R6121 T7578 T7577 arg2Of NF-κB,of
R6122 T7580 T7579 arg2Of 15,[
R6123 T7580 T7581 arg1Of 15,","
R6124 T7582 T7581 arg2Of 16,","
R6125 T7583 T7579 arg3Of ],[
R6126 T7586 T7584 arg1Of loop,This
R6127 T7586 T7585 arg1Of loop,autoregulatory
R6128 T7586 T7588 arg1Of loop,aggravates
R6129 T7586 T7595 arg1Of loop,induces
R6130 T7588 T7594 arg1Of aggravates,and
R6131 T7591 T7588 arg2Of effect,aggravates
R6132 T7591 T7589 arg1Of effect,the
R6133 T7591 T7590 arg1Of effect,damaging
R6134 T7591 T7592 arg1Of effect,of
R6135 T7593 T7592 arg2Of inflammation,of
R6136 T7594 T7587 arg1Of and,extremely
R6137 T7595 T7594 arg2Of induces,and
R6138 T7597 T7595 arg2Of injury,induces
R6139 T7597 T7596 arg1Of injury,secondary
R6140 T7597 T7598 arg1Of injury,to
R6141 T7599 T7598 arg2Of brain,to
R6142 T7600 T7601 arg1Of It,is
R6143 T7604 T7601 arg2Of choice,is
R6144 T7604 T7602 arg1Of choice,a
R6145 T7604 T7603 arg1Of choice,good
R6146 T7604 T7605 arg1Of choice,for
R6147 T7606 T7605 arg2Of targeting,for
R6148 T7606 T7607 arg1Of targeting,on
R6149 T7606 T7611 modOf targeting,to
R6150 T7610 T7606 arg2Of factor,targeting
R6151 T7610 T7608 arg1Of factor,an
R6152 T7610 T7609 arg1Of factor,upstream
R6153 T7612 T7611 arg1Of prevent,to
R6154 T7612 T7616 arg1Of prevent,after
R6155 T7615 T7612 arg2Of loop,prevent
R6156 T7615 T7613 arg1Of loop,such
R6157 T7615 T7614 arg1Of loop,autoregulatory
R6158 T7617 T7616 arg2Of TBI,after
R6159 T7619 T7618 arg1Of pathway,Nrf2-ARE
R6160 T7619 T7620 arg1Of pathway,has
R6161 T7619 T7621 arg1Of pathway,been
R6162 T7619 T7622 arg2Of pathway,proved
R6163 T7619 T7624 arg1Of pathway,be
R6164 T7622 T7620 arg2Of proved,has
R6165 T7622 T7621 arg2Of proved,been
R6166 T7624 T7622 arg3Of be,proved
R6167 T7624 T7623 arg1Of be,to
R6168 T7627 T7624 arg2Of regulator,be
R6169 T7627 T7625 arg1Of regulator,the
R6170 T7627 T7626 arg1Of regulator,key
R6171 T7627 T7628 arg1Of regulator,in
R6172 T7629 T7628 arg2Of reducing,in
R6173 T7631 T7630 arg1Of stress,oxidative
R6174 T7631 T7632 arg1Of stress,","
R6175 T7632 T7636 arg1Of ",",and
R6176 T7634 T7632 arg2Of damage,","
R6177 T7634 T7633 arg1Of damage,inflammatory
R6178 T7636 T7629 arg2Of and,reducing
R6179 T7636 T7635 arg1Of and,","
R6180 T7637 T7636 arg2Of accumulation,and
R6181 T7637 T7638 arg1Of accumulation,of
R6182 T7640 T7638 arg2Of metabolites,of
R6183 T7640 T7639 arg1Of metabolites,toxic
R6184 T7640 T7641 arg1Of metabolites,","
R6185 T7640 T7642 arg1Of metabolites,which
R6186 T7640 T7643 arg1Of metabolites,are
R6187 T7640 T7645 arg2Of metabolites,involved
R6188 T7645 T7643 arg2Of involved,are
R6189 T7645 T7644 arg1Of involved,all
R6190 T7645 T7646 arg1Of involved,in
R6191 T7647 T7646 arg2Of TBI,in
R6192 T7650 T7648 arg1Of study,Our
R6193 T7650 T7649 arg1Of study,previous
R6194 T7650 T7651 arg1Of study,has
R6195 T7650 T7652 arg1Of study,proved
R6196 T7652 T7651 arg2Of proved,has
R6197 T7652 T7660 arg1Of proved,after
R6198 T7654 T7652 arg2Of augmentation,proved
R6199 T7654 T7653 arg1Of augmentation,the
R6200 T7654 T7655 arg1Of augmentation,of
R6201 T7654 T7657 arg1Of augmentation,in
R6202 T7656 T7655 arg2Of Nrf2,of
R6203 T7659 T7657 arg2Of tissue,in
R6204 T7659 T7658 arg1Of tissue,brain
R6205 T7661 T7660 arg2Of TBI,after
R6206 T7661 T7662 arg1Of TBI,[
R6207 T7663 T7662 arg2Of 17,[
R6208 T7664 T7662 arg3Of ],[
R6209 T7666 T7665 arg2Of level,Enhanced
R6210 T7666 T7667 arg1Of level,of
R6211 T7666 T7669 arg1Of level,activates
R6212 T7668 T7667 arg2Of Nrf2,of
R6213 T7670 T7669 arg2Of transcription,activates
R6214 T7670 T7671 arg1Of transcription,of
R6215 T7670 T7677 arg1Of transcription,","
R6216 T7670 T7679 arg1Of transcription,as
R6217 T7673 T7671 arg2Of group,of
R6218 T7673 T7672 arg1Of group,a
R6219 T7673 T7674 arg1Of group,of
R6220 T7676 T7674 arg2Of genes,of
R6221 T7676 T7675 arg1Of genes,antioxidant
R6222 T7679 T7678 arg1Of as,such
R6223 T7681 T7680 arg1Of oxygenase-1,heme
R6224 T7681 T7682 arg1Of oxygenase-1,(
R6225 T7681 T7685 arg1Of oxygenase-1,and
R6226 T7683 T7682 arg2Of HO-1,(
R6227 T7684 T7682 arg3Of ),(
R6228 T7685 T7679 arg2Of and,as
R6229 T7685 T7691 arg1Of and,:
R6230 T7688 T7687 arg2Of P,(
R6231 T7689 T7687 arg3Of ),(
R6232 T7690 T7685 arg2Of H,and
R6233 T7690 T7686 arg1Of H,NAD
R6234 T7690 T7687 arg1Of H,(
R6235 T7693 T7691 arg2Of oxidoreductase-1,:
R6236 T7693 T7692 arg1Of oxidoreductase-1,quinone
R6237 T7693 T7694 arg1Of oxidoreductase-1,(
R6238 T7693 T7697 arg1Of oxidoreductase-1,","
R6239 T7693 T7698 arg1Of oxidoreductase-1,which
R6240 T7693 T7699 arg1Of oxidoreductase-1,would
R6241 T7693 T7701 arg1Of oxidoreductase-1,reduce
R6242 T7695 T7694 arg2Of NQO1,(
R6243 T7696 T7694 arg3Of ),(
R6244 T7701 T7699 arg2Of reduce,would
R6245 T7701 T7700 arg1Of reduce,subsequently
R6246 T7703 T7701 arg2Of damage,reduce
R6247 T7703 T7702 arg1Of damage,the
R6248 T7703 T7704 arg1Of damage,in
R6249 T7705 T7704 arg2Of brain,in
R6250 T7705 T7706 arg1Of brain,[
R6251 T7707 T7706 arg2Of 18,[
R6252 T7708 T7706 arg3Of ],[
R6253 T7710 T7709 arg1Of administration,Postinjury
R6254 T7710 T7711 arg1Of administration,of
R6255 T7710 T7720 arg1Of administration,improves
R6256 T7710 T7726 arg1Of administration,decreases
R6257 T7712 T7711 arg2Of SFN,of
R6258 T7712 T7713 arg1Of SFN,","
R6259 T7715 T7713 arg2Of inducer,","
R6260 T7715 T7714 arg1Of inducer,an
R6261 T7715 T7716 arg1Of inducer,of
R6262 T7717 T7716 arg2Of Nrf2,of
R6263 T7720 T7725 arg1Of improves,and
R6264 T7722 T7720 arg2Of memory,improves
R6265 T7722 T7721 arg1Of memory,spatial
R6266 T7722 T7723 arg1Of memory,of
R6267 T7724 T7723 arg2Of rat,of
R6268 T7725 T7718 arg1Of and,","
R6269 T7725 T7719 arg1Of and,significantly
R6270 T7726 T7725 arg2Of decreases,and
R6271 T7728 T7726 arg2Of immunoreactivity,decreases
R6272 T7728 T7727 arg1Of immunoreactivity,the
R6273 T7728 T7729 arg1Of immunoreactivity,for
R6274 T7728 T7740 arg1Of immunoreactivity,","
R6275 T7728 T7741 arg1Of immunoreactivity,in
R6276 T7730 T7729 arg2Of 4-Hydroxynonenal,for
R6277 T7730 T7731 arg1Of 4-Hydroxynonenal,(
R6278 T7730 T7734 arg1Of 4-Hydroxynonenal,","
R6279 T7732 T7731 arg2Of 4-HNE,(
R6280 T7733 T7731 arg3Of ),(
R6281 T7736 T7734 arg2Of marker,","
R6282 T7736 T7735 arg1Of marker,a
R6283 T7736 T7737 arg1Of marker,of
R6284 T7739 T7737 arg2Of peroxidation,of
R6285 T7739 T7738 arg1Of peroxidation,lipid
R6286 T7743 T7742 arg1Of cortex,the
R6287 T7743 T7744 arg1Of cortex,and
R6288 T7744 T7741 arg2Of and,in
R6289 T7747 T7744 arg2Of subfield,and
R6290 T7747 T7745 arg1Of subfield,the
R6291 T7747 T7746 arg1Of subfield,CA3
R6292 T7747 T7748 arg1Of subfield,of
R6293 T7747 T7750 arg1Of subfield,after
R6294 T7749 T7748 arg2Of hippocampus,of
R6295 T7751 T7750 arg2Of TBI,after
R6296 T7751 T7752 arg1Of TBI,[
R6297 T7753 T7752 arg2Of 19,[
R6298 T7754 T7752 arg3Of ],[
R6299 T7758 T7755 arg2Of hand,On
R6300 T7758 T7756 arg1Of hand,the
R6301 T7758 T7757 arg1Of hand,other
R6302 T7761 T7760 arg1Of mice,Nrf2-deficient
R6303 T7761 T7762 arg1Of mice,appear
R6304 T7761 T7764 arg1Of mice,susceptible
R6305 T7762 T7755 arg1Of appear,On
R6306 T7762 T7759 arg1Of appear,","
R6307 T7764 T7762 arg2Of susceptible,appear
R6308 T7764 T7763 arg1Of susceptible,more
R6309 T7764 T7765 arg1Of susceptible,to
R6310 T7766 T7765 arg2Of TBI,to
R6311 T7767 T7768 arg1Of Depletion,of
R6312 T7767 T7770 arg1Of Depletion,induces
R6313 T7769 T7768 arg2Of Nrf2,of
R6314 T7770 T7776 arg1Of induces,in
R6315 T7772 T7770 arg2Of expression,induces
R6316 T7772 T7771 arg1Of expression,higher
R6317 T7772 T7773 arg1Of expression,of
R6318 T7775 T7773 arg2Of mediators,of
R6319 T7775 T7774 arg1Of mediators,proinflammatory
R6320 T7777 T7776 arg2Of brain,in
R6321 T7777 T7778 arg1Of brain,after
R6322 T7779 T7778 arg2Of TBI,after
R6323 T7779 T7780 arg1Of TBI,[
R6324 T7781 T7780 arg2Of 20,[
R6325 T7782 T7780 arg3Of ],[
R6326 T7786 T7785 arg1Of results,our
R6327 T7786 T7787 arg1Of results,revealed
R6328 T7787 T7783 arg1Of revealed,Here
R6329 T7787 T7784 arg1Of revealed,","
R6330 T7789 T7790 arg1Of overexpression,of
R6331 T7789 T7802 arg1Of overexpression,was
R6332 T7789 T7804 arg2Of overexpression,aggravated
R6333 T7791 T7792 arg1Of TNF-α,","
R6334 T7792 T7794 arg1Of ",",","
R6335 T7793 T7792 arg2Of IL-1β,","
R6336 T7794 T7797 arg1Of ",",and
R6337 T7795 T7794 arg2Of IL-6,","
R6338 T7797 T7790 arg2Of and,of
R6339 T7797 T7796 arg1Of and,","
R6340 T7797 T7799 arg1Of and,after
R6341 T7798 T7797 arg2Of MMP9,and
R6342 T7801 T7799 arg2Of injury,after
R6343 T7801 T7800 arg1Of injury,scratch
R6344 T7804 T7802 arg2Of aggravated,was
R6345 T7804 T7803 arg1Of aggravated,more
R6346 T7804 T7805 arg1Of aggravated,in
R6347 T7804 T7810 arg1Of aggravated,than
R6348 T7804 T7814 arg1Of aggravated,for
R6349 T7804 T7819 arg1Of aggravated,and
R6350 T7809 T7805 arg2Of astrocytes,in
R6351 T7809 T7806 arg2Of astrocytes,cultured
R6352 T7809 T7807 arg1Of astrocytes,Nrf2
R6353 T7809 T7808 arg1Of astrocytes,knockout
R6354 T7811 T7810 arg2Of in,than
R6355 T7813 T7811 arg2Of astrocyetes,in
R6356 T7813 T7812 arg1Of astrocyetes,wildtype
R6357 T7817 T7814 arg2Of time,for
R6358 T7817 T7815 arg1Of time,the
R6359 T7817 T7816 arg1Of time,first
R6360 T7819 T7787 arg2Of and,revealed
R6361 T7819 T7788 arg1Of and,that
R6362 T7819 T7818 arg1Of and,","
R6363 T7820 T7821 arg1Of overexpression,of
R6364 T7820 T7825 arg1Of overexpression,led
R6365 T7824 T7821 arg2Of mediators,of
R6366 T7824 T7822 arg1Of mediators,these
R6367 T7824 T7823 arg1Of mediators,proinflammatory
R6368 T7825 T7819 arg2Of led,and
R6369 T7825 T7826 arg1Of led,to
R6370 T7829 T7826 arg2Of deaths,to
R6371 T7829 T7827 arg1Of deaths,more
R6372 T7829 T7828 arg1Of deaths,astrocytes
R6373 T7830 T7831 arg2Of Data,obtained
R6374 T7830 T7835 arg1Of Data,suggest
R6375 T7831 T7832 arg1Of obtained,from
R6376 T7834 T7832 arg2Of studies,from
R6377 T7834 T7833 arg1Of studies,animal
R6378 T7837 T7835 arg2Of possibility,suggest
R6379 T7837 T7836 arg1Of possibility,the
R6380 T7840 T7839 arg1Of effect,antioxidant
R6381 T7840 T7841 arg1Of effect,of
R6382 T7840 T7843 arg1Of effect,may
R6383 T7840 T7844 arg1Of effect,be
R6384 T7840 T7845 arg2Of effect,achieved
R6385 T7842 T7841 arg2Of Nrf2,of
R6386 T7845 T7837 arg2Of achieved,possibility
R6387 T7845 T7838 arg1Of achieved,that
R6388 T7845 T7843 arg2Of achieved,may
R6389 T7845 T7844 arg2Of achieved,be
R6390 T7847 T7845 arg1Of suppression,achieved
R6391 T7847 T7846 arg2Of suppression,by
R6392 T7847 T7848 arg1Of suppression,of
R6393 T7850 T7848 arg2Of pathways,of
R6394 T7850 T7849 arg1Of pathways,proinflammatory
R6395 T7850 T7851 arg1Of pathways,which
R6396 T7850 T7852 arg1Of pathways,are
R6397 T7850 T7853 arg2Of pathways,mediated
R6398 T7853 T7852 arg2Of mediated,are
R6399 T7856 T7853 arg1Of signaling,mediated
R6400 T7856 T7854 arg2Of signaling,by
R6401 T7856 T7855 arg1Of signaling,NF-κB
R6402 T7857 T7858 arg1Of Administration,of
R6403 T7857 T7860 arg1Of Administration,is
R6404 T7857 T7861 arg2Of Administration,found
R6405 T7857 T7863 arg1Of Administration,be
R6406 T7857 T7864 arg1Of Administration,able
R6407 T7857 T7866 arg1Of Administration,inhibit
R6408 T7857 T7877 arg1Of Administration,alleviating
R6409 T7859 T7858 arg2Of SFN,of
R6410 T7861 T7860 arg2Of found,is
R6411 T7863 T7861 arg3Of be,found
R6412 T7863 T7862 arg1Of be,to
R6413 T7864 T7863 arg2Of able,be
R6414 T7866 T7864 arg2Of inhibit,able
R6415 T7866 T7865 arg1Of inhibit,to
R6416 T7866 T7875 arg1Of inhibit,","
R6417 T7866 T7877 modOf inhibit,alleviating
R6418 T7868 T7867 arg1Of phosphorylation,IKK/IκB
R6419 T7868 T7869 arg1Of phosphorylation,and
R6420 T7869 T7866 arg2Of and,inhibit
R6421 T7874 T7869 arg2Of translocation,and
R6422 T7874 T7870 arg1Of translocation,p65
R6423 T7874 T7871 arg1Of translocation,NF-κB
R6424 T7874 T7872 arg1Of translocation,subunit
R6425 T7874 T7873 arg1Of translocation,nuclear
R6426 T7877 T7876 arg1Of alleviating,consequently
R6427 T7879 T7877 arg2Of signaling,alleviating
R6428 T7879 T7878 arg1Of signaling,NF-κB
R6429 T7879 T7880 arg1Of signaling,[
R6430 T7881 T7880 arg2Of 21,[
R6431 T7882 T7880 arg3Of ],[
R6432 T7885 T7884 arg1Of activation,NF-κB
R6433 T7885 T7886 arg2Of activation,induced
R6434 T7885 T7892 arg1Of activation,could
R6435 T7885 T7893 arg1Of activation,be
R6436 T7885 T7894 arg2Of activation,attenuated
R6437 T7888 T7886 arg1Of lipopolysaccharide,induced
R6438 T7888 T7887 arg2Of lipopolysaccharide,by
R6439 T7888 T7889 arg1Of lipopolysaccharide,(
R6440 T7890 T7889 arg2Of LPS,(
R6441 T7891 T7889 arg3Of ),(
R6442 T7894 T7883 arg1Of attenuated,And
R6443 T7894 T7892 arg2Of attenuated,could
R6444 T7894 T7893 arg2Of attenuated,be
R6445 T7894 T7908 arg1Of attenuated,[
R6446 T7898 T7894 arg1Of activators,attenuated
R6447 T7898 T7895 arg2Of activators,by
R6448 T7898 T7896 arg1Of activators,diverse
R6449 T7898 T7897 arg1Of activators,Nrf2
R6450 T7898 T7899 arg1Of activators,","
R6451 T7898 T7901 arg1Of activators,as
R6452 T7901 T7900 arg1Of as,such
R6453 T7902 T7903 arg1Of SFN,and
R6454 T7903 T7901 arg2Of and,as
R6455 T7903 T7905 arg1Of and,(
R6456 T7904 T7903 arg2Of curcumin,and
R6457 T7906 T7905 arg2Of CUR,(
R6458 T7907 T7905 arg3Of ),(
R6459 T7909 T7908 arg2Of 22,[
R6460 T7910 T7908 arg3Of ],[
R6461 T7915 T7913 arg1Of studies,our
R6462 T7915 T7914 arg1Of studies,previous
R6463 T7915 T7916 arg1Of studies,indicate
R6464 T7916 T7911 arg1Of indicate,Furthermore
R6465 T7916 T7912 arg1Of indicate,","
R6466 T7918 T7919 arg1Of depletion,of
R6467 T7918 T7921 arg1Of depletion,induces
R6468 T7920 T7919 arg2Of Nrf2,of
R6469 T7921 T7916 arg2Of induces,indicate
R6470 T7921 T7917 arg1Of induces,that
R6471 T7922 T7921 arg2Of augmentation,induces
R6472 T7922 T7923 arg1Of augmentation,of
R6473 T7922 T7929 arg1Of augmentation,in
R6474 T7922 T7936 arg1Of augmentation,after
R6475 T7925 T7924 arg1Of activity,NF-κB
R6476 T7925 T7926 arg1Of activity,and
R6477 T7926 T7923 arg2Of and,of
R6478 T7928 T7926 arg2Of response,and
R6479 T7928 T7927 arg1Of response,inflammatory
R6480 T7930 T7931 arg1Of lung,","
R6481 T7931 T7934 arg1Of ",",and
R6482 T7932 T7931 arg2Of brain,","
R6483 T7934 T7929 arg2Of and,in
R6484 T7934 T7933 arg1Of and,","
R6485 T7935 T7934 arg2Of intestine,and
R6486 T7937 T7936 arg2Of TBI,after
R6487 T7937 T7938 arg1Of TBI,[
R6488 T7939 T7940 arg1Of 4,","
R6489 T7940 T7938 arg2Of ",",[
R6490 T7940 T7942 arg1Of ",",","
R6491 T7941 T7940 arg2Of 5,","
R6492 T7943 T7942 arg2Of 23,","
R6493 T7944 T7938 arg3Of ],[
R6494 T7945 T7946 arg1Of Results,from
R6495 T7945 T7950 arg1Of Results,confirmed
R6496 T7948 T7946 arg2Of study,from
R6497 T7948 T7947 arg1Of study,this
R6498 T7950 T7949 arg1Of confirmed,further
R6499 T7952 T7951 arg1Of relationship,such
R6500 T7952 T7953 arg1Of relationship,existed
R6501 T7953 T7950 arg2Of existed,confirmed
R6502 T7953 T7954 arg1Of existed,in
R6503 T7953 T7957 arg1Of existed,after
R6504 T7956 T7954 arg2Of astrocytes,in
R6505 T7956 T7955 arg2Of astrocytes,cultured
R6506 T7959 T7957 arg2Of injury,after
R6507 T7959 T7958 arg1Of injury,scratch
R6508 T7961 T7960 arg2Of activation,Enhanced
R6509 T7961 T7962 arg1Of activation,of
R6510 T7961 T7964 arg1Of activation,is
R6511 T7961 T7966 arg2Of activation,discovered
R6512 T7963 T7962 arg2Of NF-κB,of
R6513 T7966 T7964 arg2Of discovered,is
R6514 T7966 T7965 arg1Of discovered,also
R6515 T7966 T7967 arg1Of discovered,in
R6516 T7966 T7979 arg1Of discovered,after
R6517 T7966 T7982 arg1Of discovered,[
R6518 T7968 T7969 arg1Of lung,","
R6519 T7969 T7972 arg1Of ",",and
R6520 T7970 T7969 arg2Of macrophages,","
R6521 T7972 T7967 arg2Of and,in
R6522 T7972 T7971 arg1Of and,","
R6523 T7975 T7972 arg2Of fibroblasts,and
R6524 T7975 T7973 arg1Of fibroblasts,mouse
R6525 T7975 T7974 arg1Of fibroblasts,embryonic
R6526 T7975 T7976 arg1Of fibroblasts,of
R6527 T7978 T7976 arg2Of mice,of
R6528 T7978 T7977 arg1Of mice,Nrf2-deficient
R6529 T7981 T7979 arg2Of sepsis,after
R6530 T7981 T7980 arg1Of sepsis,experimental
R6531 T7983 T7982 arg2Of 24,[
R6532 T7984 T7982 arg3Of ],[
R6533 T7987 T7988 arg1Of it,is
R6534 T7987 T7989 arg2Of it,reported
R6535 T7989 T7985 arg1Of reported,Interestingly
R6536 T7989 T7986 arg1Of reported,","
R6537 T7989 T7988 arg2Of reported,is
R6538 T7991 T7992 arg1Of NF-κB,can
R6539 T7991 T7993 arg1Of NF-κB,inhibit
R6540 T7993 T7989 arg3Of inhibit,reported
R6541 T7993 T7990 arg1Of inhibit,that
R6542 T7993 T7992 arg2Of inhibit,can
R6543 T7993 T7995 arg1Of inhibit,at
R6544 T7994 T7993 arg2Of Nrf2,inhibit
R6545 T7997 T7995 arg2Of level,at
R6546 T7997 T7996 arg1Of level,transcriptional
R6547 T8000 T7998 arg1Of subunit,NF-κB
R6548 T8000 T7999 arg1Of subunit,p65
R6549 T8000 T8001 arg1Of subunit,repressed
R6550 T8001 T8008 arg1Of repressed,by
R6551 T8004 T8001 arg2Of pathway,repressed
R6552 T8004 T8002 arg1Of pathway,the
R6553 T8004 T8003 arg1Of pathway,Nrf2-ARE
R6554 T8004 T8005 arg1Of pathway,at
R6555 T8007 T8005 arg2Of level,at
R6556 T8007 T8006 arg1Of level,transcriptional
R6557 T8010 T8009 arg1Of interaction,competitive
R6558 T8010 T8011 arg1Of interaction,with
R6559 T8010 T8017 arg1Of interaction,or
R6560 T8014 T8011 arg2Of domain,with
R6561 T8014 T8012 arg1Of domain,the
R6562 T8014 T8013 arg1Of domain,CH1-KIX
R6563 T8014 T8015 arg1Of domain,of
R6564 T8016 T8015 arg2Of CBP,of
R6565 T8017 T8008 arg2Of or,by
R6566 T8020 T8017 arg2Of hypoacetylation,or
R6567 T8020 T8018 arg1Of hypoacetylation,local
R6568 T8020 T8019 arg1Of hypoacetylation,histone
R6569 T8020 T8021 arg1Of hypoacetylation,[
R6570 T8022 T8021 arg2Of 25,[
R6571 T8023 T8021 arg3Of ],[
R6572 T8026 T8024 arg1Of findings,All
R6573 T8026 T8025 arg1Of findings,these
R6574 T8026 T8027 arg1Of findings,indicate
R6575 T8031 T8027 arg2Of crosstalk,indicate
R6576 T8031 T8028 arg1Of crosstalk,the
R6577 T8031 T8029 arg1Of crosstalk,potential
R6578 T8031 T8030 arg1Of crosstalk,complicate
R6579 T8031 T8032 arg1Of crosstalk,between
R6580 T8033 T8034 arg1Of NF-κB,and
R6581 T8034 T8032 arg2Of and,between
R6582 T8034 T8036 arg1Of and,","
R6583 T8034 T8037 arg1Of and,which
R6584 T8034 T8038 arg1Of and,may
R6585 T8034 T8039 arg1Of and,be
R6586 T8034 T8040 arg2Of and,regulated
R6587 T8035 T8034 arg2Of Nrf2,and
R6588 T8040 T8038 arg2Of regulated,may
R6589 T8040 T8039 arg2Of regulated,be
R6590 T8040 T8051 arg1Of regulated,[
R6591 T8046 T8044 arg1Of kinase,mitogen-activated
R6592 T8046 T8045 arg1Of kinase,protein
R6593 T8046 T8047 arg1Of kinase,(
R6594 T8048 T8047 arg2Of MAPKs,(
R6595 T8049 T8047 arg3Of ),(
R6596 T8050 T8040 arg1Of pathway,regulated
R6597 T8050 T8041 arg2Of pathway,by
R6598 T8050 T8042 arg1Of pathway,the
R6599 T8050 T8043 arg1Of pathway,upstream
R6600 T8050 T8046 arg1Of pathway,kinase
R6601 T8052 T8051 arg2Of 26,[
R6602 T8053 T8051 arg3Of ],[
R6603 T8057 T8055 arg2Of confirmed,has
R6604 T8057 T8056 arg2Of confirmed,been
R6605 T8059 T8060 arg1Of Nrf2,is
R6606 T8059 T8062 arg2Of Nrf2,detected
R6607 T8062 T8054 arg1Of detected,It
R6608 T8062 T8055 arg1Of detected,has
R6609 T8062 T8056 arg1Of detected,been
R6610 T8062 T8057 arg2Of detected,confirmed
R6611 T8062 T8058 arg1Of detected,that
R6612 T8062 T8060 arg2Of detected,is
R6613 T8062 T8061 arg1Of detected,mainly
R6614 T8062 T8063 arg1Of detected,in
R6615 T8064 T8063 arg2Of nucleus,in
R6616 T8064 T8065 arg1Of nucleus,of
R6617 T8066 T8065 arg2Of astrocytes,of
R6618 T8066 T8067 arg1Of astrocytes,after
R6619 T8068 T8067 arg2Of TBI,after
R6620 T8068 T8069 arg1Of TBI,[
R6621 T8070 T8069 arg2Of 18,[
R6622 T8071 T8069 arg3Of ],[
R6623 T8073 T8072 arg2Of view,In
R6624 T8073 T8074 arg1Of view,of
R6625 T8076 T8074 arg2Of fact,of
R6626 T8076 T8075 arg1Of fact,the
R6627 T8078 T8079 arg1Of Nrf2,is
R6628 T8079 T8076 arg2Of is,fact
R6629 T8079 T8077 arg1Of is,that
R6630 T8082 T8079 arg2Of factor,is
R6631 T8082 T8080 arg1Of factor,a
R6632 T8082 T8081 arg1Of factor,transcription
R6633 T8082 T8083 arg1Of factor,which
R6634 T8082 T8084 arg1Of factor,should
R6635 T8082 T8085 arg1Of factor,take
R6636 T8085 T8084 arg2Of take,should
R6637 T8085 T8088 arg1Of take,in
R6638 T8086 T8085 arg2Of function,take
R6639 T8088 T8087 arg1Of in,mainly
R6640 T8089 T8088 arg2Of nucleus,in
R6641 T8091 T8092 arg1Of it,can
R6642 T8091 T8093 arg1Of it,be
R6643 T8091 T8094 arg2Of it,reasoned
R6644 T8094 T8072 arg1Of reasoned,In
R6645 T8094 T8090 arg1Of reasoned,","
R6646 T8094 T8092 arg2Of reasoned,can
R6647 T8094 T8093 arg2Of reasoned,be
R6648 T8096 T8097 arg1Of astrocytes,may
R6649 T8096 T8098 arg1Of astrocytes,be
R6650 T8098 T8094 arg3Of be,reasoned
R6651 T8098 T8095 arg1Of be,that
R6652 T8098 T8097 arg2Of be,may
R6653 T8098 T8104 arg1Of be,in
R6654 T8100 T8098 arg2Of kind,be
R6655 T8100 T8099 arg1Of kind,one
R6656 T8100 T8101 arg1Of kind,of
R6657 T8103 T8101 arg2Of cells,of
R6658 T8103 T8102 arg1Of cells,respondent
R6659 T8105 T8104 arg2Of activation,in
R6660 T8105 T8106 arg1Of activation,of
R6661 T8108 T8106 arg2Of pathway,of
R6662 T8108 T8107 arg1Of pathway,Nrf2-ARE
R6663 T8108 T8109 arg1Of pathway,after
R6664 T8110 T8109 arg2Of TBI,after
R6665 T8112 T8111 arg1Of study,Previous
R6666 T8112 T8113 arg1Of study,identified
R6667 T8113 T8126 arg1Of identified,after
R6668 T8115 T8113 arg2Of expression,identified
R6669 T8115 T8114 arg1Of expression,the
R6670 T8115 T8116 arg1Of expression,of
R6671 T8115 T8123 arg1Of expression,in
R6672 T8117 T8118 arg1Of TNF-α,","
R6673 T8118 T8121 arg1Of ",",and
R6674 T8119 T8118 arg2Of IL-1β,","
R6675 T8121 T8116 arg2Of and,of
R6676 T8121 T8120 arg1Of and,","
R6677 T8122 T8121 arg2Of IL-6,and
R6678 T8125 T8123 arg2Of astrocytes,in
R6679 T8125 T8124 arg2Of astrocytes,cultured
R6680 T8127 T8126 arg2Of treatment,after
R6681 T8127 T8128 arg1Of treatment,with
R6682 T8129 T8130 arg1Of LPS,or
R6683 T8130 T8128 arg2Of or,with
R6684 T8130 T8132 arg1Of or,[
R6685 T8131 T8130 arg2Of oxyhemoglobin,or
R6686 T8133 T8132 arg2Of 27,[
R6687 T8133 T8134 arg1Of 27,","
R6688 T8135 T8134 arg2Of 28,","
R6689 T8136 T8132 arg3Of ],[
R6690 T8138 T8137 arg1Of study,Another
R6691 T8138 T8139 arg1Of study,revealed
R6692 T8145 T8141 arg2Of occlusion,after
R6693 T8145 T8142 arg1Of occlusion,middle
R6694 T8145 T8143 arg1Of occlusion,cerebral
R6695 T8145 T8144 arg1Of occlusion,artery
R6696 T8148 T8147 arg1Of astrocytes,MMP9-positive
R6697 T8148 T8149 arg1Of astrocytes,were
R6698 T8148 T8150 arg2Of astrocytes,observed
R6699 T8150 T8139 arg2Of observed,revealed
R6700 T8150 T8140 arg1Of observed,that
R6701 T8150 T8141 arg1Of observed,after
R6702 T8150 T8146 arg1Of observed,","
R6703 T8150 T8149 arg2Of observed,were
R6704 T8150 T8151 arg1Of observed,in
R6705 T8150 T8154 arg1Of observed,by
R6706 T8150 T8156 arg1Of observed,[
R6707 T8153 T8151 arg2Of tissues,in
R6708 T8153 T8152 arg1Of tissues,brain
R6709 T8155 T8154 arg2Of immunohistochemistry,by
R6710 T8157 T8156 arg2Of 29,[
R6711 T8158 T8156 arg3Of ],[
R6712 T8160 T8159 arg1Of results,Those
R6713 T8160 T8161 arg1Of results,indicate
R6714 T8161 T8169 arg1Of indicate,after
R6715 T8163 T8161 arg2Of role,indicate
R6716 T8163 T8162 arg1Of role,the
R6717 T8163 T8164 arg1Of role,of
R6718 T8163 T8166 arg1Of role,in
R6719 T8165 T8164 arg2Of astrocytes,of
R6720 T8168 T8166 arg2Of process,in
R6721 T8168 T8167 arg1Of process,inflammatory
R6722 T8171 T8169 arg2Of injury,after
R6723 T8171 T8170 arg1Of injury,brain
R6724 T8174 T8177 modOf now,is
R6725 T8174 T8180 arg1Of now,focused
R6726 T8176 T8177 arg1Of there,is
R6727 T8177 T8175 arg1Of is,","
R6728 T8179 T8177 arg2Of study,is
R6729 T8179 T8178 arg1Of study,no
R6730 T8180 T8172 arg1Of focused,But
R6731 T8180 T8173 arg1Of focused,till
R6732 T8180 T8181 arg1Of focused,on
R6733 T8180 T8192 arg1Of focused,after
R6734 T8183 T8181 arg2Of relationship,on
R6735 T8183 T8182 arg1Of relationship,the
R6736 T8183 T8184 arg1Of relationship,among
R6737 T8185 T8186 arg1Of astrocytes,","
R6738 T8186 T8189 arg1Of ",",and
R6739 T8187 T8186 arg2Of Nrf2,","
R6740 T8189 T8184 arg2Of and,among
R6741 T8189 T8188 arg1Of and,","
R6742 T8191 T8189 arg2Of mediators,and
R6743 T8191 T8190 arg1Of mediators,proinflammatory
R6744 T8193 T8192 arg2Of TBI,after
R6745 T8195 T8194 arg1Of results,Our
R6746 T8195 T8196 arg1Of results,demonstrated
R6747 T8199 T8196 arg2Of expression,demonstrated
R6748 T8199 T8197 arg1Of expression,the
R6749 T8199 T8198 arg2Of expression,upregulated
R6750 T8199 T8200 arg1Of expression,of
R6751 T8199 T8209 arg1Of expression,in
R6752 T8201 T8202 arg1Of TNF-α,","
R6753 T8202 T8204 arg1Of ",",","
R6754 T8203 T8202 arg2Of IL-1β,","
R6755 T8204 T8207 arg1Of ",",and
R6756 T8205 T8204 arg2Of IL-6,","
R6757 T8207 T8200 arg2Of and,of
R6758 T8207 T8206 arg1Of and,","
R6759 T8208 T8207 arg2Of MMP9,and
R6760 T8212 T8209 arg2Of astrocytes,in
R6761 T8212 T8210 arg1Of astrocytes,Nrf2
R6762 T8212 T8211 arg1Of astrocytes,knockout
R6763 T8212 T8213 arg1Of astrocytes,after
R6764 T8215 T8213 arg2Of injury,after
R6765 T8215 T8214 arg1Of injury,scratch
R6766 T8215 T8216 arg1Of injury,for
R6767 T8219 T8216 arg2Of time,for
R6768 T8219 T8217 arg1Of time,the
R6769 T8219 T8218 arg1Of time,first
R6770 T8221 T8220 arg2Of conclusion,In
R6771 T8223 T8224 arg1Of depletion,of
R6772 T8223 T8226 arg1Of depletion,induced
R6773 T8225 T8224 arg2Of Nrf2,of
R6774 T8226 T8220 arg1Of induced,In
R6775 T8226 T8222 arg1Of induced,","
R6776 T8226 T8243 modOf induced,resulting
R6777 T8228 T8227 arg1Of activation,the
R6778 T8228 T8229 arg1Of activation,of
R6779 T8228 T8231 arg1Of activation,and
R6780 T8230 T8229 arg2Of NF-κB,of
R6781 T8231 T8226 arg2Of and,induced
R6782 T8233 T8231 arg2Of expression,and
R6783 T8233 T8232 arg1Of expression,the
R6784 T8233 T8234 arg1Of expression,of
R6785 T8235 T8236 arg1Of TNF-α,","
R6786 T8236 T8238 arg1Of ",",","
R6787 T8237 T8236 arg2Of IL-1β,","
R6788 T8238 T8241 arg1Of ",",and
R6789 T8239 T8238 arg2Of IL-6,","
R6790 T8241 T8234 arg2Of and,of
R6791 T8241 T8240 arg1Of and,","
R6792 T8242 T8241 arg2Of MMP9,and
R6793 T8243 T8244 arg1Of resulting,in
R6794 T8247 T8244 arg2Of deaths,in
R6795 T8247 T8245 arg1Of deaths,more
R6796 T8247 T8246 arg1Of deaths,cell
R6797 T8247 T8248 arg1Of deaths,in
R6798 T8249 T8248 arg2Of astrocytes,in
R6799 T8249 T8250 arg1Of astrocytes,after
R6800 T8252 T8250 arg2Of injury,after
R6801 T8252 T8251 arg1Of injury,scratch
R6802 T8254 T8253 arg1Of results,These
R6803 T8254 T8255 arg1Of results,suggest
R6804 T8257 T8258 arg1Of Nrf2,may
R6805 T8257 T8259 arg1Of Nrf2,be
R6806 T8259 T8255 arg2Of be,suggest
R6807 T8259 T8256 arg1Of be,that
R6808 T8259 T8258 arg2Of be,may
R6809 T8262 T8259 arg2Of target,be
R6810 T8262 T8260 arg1Of target,an
R6811 T8262 T8261 arg1Of target,important
R6812 T8262 T8263 arg1Of target,for
R6813 T8262 T8266 arg1Of target,after
R6814 T8265 T8263 arg2Of therapy,for
R6815 T8265 T8264 arg1Of therapy,anti-inflammatory
R6816 T8267 T8266 arg2Of TBI,after

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T7341 5152-5156 Protein denotes MMP9
T7340 5142-5146 Protein denotes IL-6
T7339 5135-5140 Protein denotes IL-1β
T7338 4967-4971 Protein denotes MMP9
T7337 4957-4961 Protein denotes IL-6
T7336 4950-4955 Protein denotes IL-1β
T7335 4587-4591 Protein denotes MMP9
T7334 4439-4443 Protein denotes IL-6
T7333 4428-4433 Protein denotes IL-1β
T7332 3721-3724 Protein denotes p65
T7331 2948-2951 Protein denotes p65
T7330 2462-2466 Protein denotes MMP9
T7329 2452-2456 Protein denotes IL-6
T7328 2445-2450 Protein denotes IL-1β
T7327 1846-1850 Protein denotes HO-1
T7326 1828-1844 Protein denotes heme oxygenase-1
T7325 1199-1204 Protein denotes IL-1β
T7324 1143-1147 Protein denotes MMP9
T7323 1112-1116 Protein denotes IL-6
T7322 1079-1083 Protein denotes MMP9
T7321 1046-1051 Protein denotes IL-1β
T7320 846-850 Protein denotes MMP9
T7319 687-691 Protein denotes IL-6
T7318 676-681 Protein denotes IL-1β
T7317 610-614 Protein denotes MMP9
T7316 166-170 Protein denotes MMP9
T7315 156-160 Protein denotes IL-6
T7314 149-154 Protein denotes IL-1β

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T8392 3843-3846 http://www.uniprot.org/uniprot/Q92793 denotes CBP
T8391 3721-3724 http://www.uniprot.org/uniprot/P21579 denotes p65
T8390 2948-2951 http://www.uniprot.org/uniprot/P21579 denotes p65
T8389 3721-3724 http://www.uniprot.org/uniprot/Q04206 denotes p65
T8388 2948-2951 http://www.uniprot.org/uniprot/Q04206 denotes p65
T8387 1103-1114 http://www.uniprot.org/uniprot/P35225 denotes 13], and IL
T8386 5142-5146 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8385 4957-4961 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8384 4439-4443 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8383 2452-2456 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8382 1112-1116 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8381 687-691 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8375 1199-1204 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T8374 1046-1051 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T8373 676-681 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T8372 149-154 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T8371 5128-5133 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8370 4943-4948 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8369 4421-4426 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8368 2438-2443 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8367 1189-1194 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8366 1036-1041 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8365 669-674 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8364 142-147 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T8363 4943-4946 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8362 4421-4424 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8361 2438-2441 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8360 1189-1192 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8359 1036-1039 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8358 669-672 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8357 142-145 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8380 156-160 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8379 5135-5140 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T8378 4950-4955 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T8377 4428-4433 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T8376 2445-2450 http://www.uniprot.org/uniprot/P01584 denotes IL-1β

UBERON-AE

Id Subject Object Predicate Lexical cue
T7213 4569-4575 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T7212 4560-4575 http://purl.obolibrary.org/obo/UBERON_0004449 denotes cerebral artery
T7211 4553-4575 http://purl.obolibrary.org/obo/UBERON_0001627 denotes middle cerebral artery
T7210 3329-3338 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T7209 3525-3529 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T7208 3312-3316 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T7207 2160-2166 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T7206 1157-1162 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T7205 1717-1723 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T7204 702-709 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T7203 471-482 http://purl.obolibrary.org/obo/UBERON_0002240 denotes spinal cord
T7202 4749-4754 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7201 4629-4634 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7200 3318-3323 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7199 2366-2371 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7198 1945-1950 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7197 1711-1716 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7196 1365-1370 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7195 696-701 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T7194 461-466 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain

GO-BP

Id Subject Object Predicate Lexical cue
T7367 5175-5186 http://purl.obolibrary.org/obo/GO_0008219 denotes cell deaths
T7366 4326-4345 http://purl.obolibrary.org/obo/GO_0001775 denotes cells in activation
T7365 4020-4044 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T7364 4020-4044 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T7363 4020-4044 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T7362 4020-4044 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T7361 2928-2943 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7360 2920-2923 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T7359 3020-3029 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7358 2856-2865 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7357 3014-3029 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T7356 2850-2865 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T7355 5180-5186 http://purl.obolibrary.org/obo/GO_0016265 denotes deaths
T7354 2671-2677 http://purl.obolibrary.org/obo/GO_0016265 denotes deaths
T7353 2042-2048 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T7352 1892-1896 http://purl.obolibrary.org/obo/GO_0003955 denotes NQO1
T7351 1833-1842 http://purl.obolibrary.org/obo/GO_0016701 denotes oxygenase
T7350 3287-3308 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T7349 1320-1332 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T7348 4194-4207 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7347 1773-1786 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7346 593-606 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7345 5086-5105 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T7344 3483-3502 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T7343 1221-1240 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T7342 439-457 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB is activated

GO-MF

Id Subject Object Predicate Lexical cue
T8295 4020-4044 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T8294 3843-3846 http://purl.obolibrary.org/obo/GO_0008140 denotes CBP
T8293 2920-2923 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8287 4957-4961 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T8286 4439-4443 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T8285 2452-2456 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T8284 1112-1116 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T8283 687-691 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T8282 156-160 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T8281 810-817 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T8280 103-110 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T8279 806-817 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T8278 99-110 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T8292 1892-1896 http://purl.obolibrary.org/obo/GO_0003955 denotes NQO1
T8291 1833-1842 http://purl.obolibrary.org/obo/GO_0016701 denotes oxygenase
T8290 1103-1114 http://purl.obolibrary.org/obo/GO_0005144 denotes 13], and IL
T8289 5142-5146 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6

GO-CC

Id Subject Object Predicate Lexical cue
T8300 4252-4259 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T8299 4121-4128 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T8298 5175-5179 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8297 4326-4331 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8296 1173-1178 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T7247 5223-5322 Sentence denotes These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI.
T7246 5041-5222 Sentence denotes In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury.
T7245 4888-5040 Sentence denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9 in Nrf2 knockout astrocytes after scratch injury for the first time.
T7244 4763-4887 Sentence denotes But till now, there is no study focused on the relationship among astrocytes, Nrf2, and proinflammatory mediators after TBI.
T7243 4673-4762 Sentence denotes Those results indicate the role of astrocytes in inflammatory process after brain injury.
T7242 4519-4672 Sentence denotes Another study revealed that after middle cerebral artery occlusion, MMP9-positive astrocytes were observed in brain tissues by immunohistochemistry [29].
T7241 4377-4518 Sentence denotes Previous study identified the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes after treatment with LPS or oxyhemoglobin [27, 28].
T7240 4159-4376 Sentence denotes In view of the fact that Nrf2 is a transcription factor which should take function mainly in nucleus, it can be reasoned that astrocytes may be one kind of respondent cells in activation of Nrf2-ARE pathway after TBI.
T7239 4067-4158 Sentence denotes It has been confirmed that Nrf2 is mainly detected in nucleus of astrocytes after TBI [18].
T7238 3886-4066 Sentence denotes All these findings indicate the potential complicate crosstalk between NF-κB and Nrf2, which may be regulated by the upstream mitogen-activated protein kinase (MAPKs) pathway [26].
T7237 3715-3885 Sentence denotes NF-κB p65 subunit repressed the Nrf2-ARE pathway at transcriptional level by competitive interaction with the CH1-KIX domain of CBP or local histone hypoacetylation [25].
T7236 3631-3714 Sentence denotes Interestingly, it is reported that NF-κB can inhibit Nrf2 at transcriptional level.
T7235 3474-3630 Sentence denotes Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts of Nrf2-deficient mice after experimental sepsis [24].
T7234 3361-3473 Sentence denotes Results from this study further confirmed such relationship existed in cultured astrocytes after scratch injury.
T7233 3178-3360 Sentence denotes Furthermore, our previous studies indicate that depletion of Nrf2 induces augmentation of NF-κB activity and inflammatory response in lung, brain, and intestine after TBI [4, 5, 23].
T7232 3036-3177 Sentence denotes And NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by diverse Nrf2 activators, such as SFN and curcumin (CUR) [22].
T7231 2867-3035 Sentence denotes Administration of SFN is found to be able to inhibit IKK/IκB phosphorylation and p65 NF-κB subunit nuclear translocation, consequently alleviating NF-κB signaling [21].
T7230 2679-2866 Sentence denotes Data obtained from animal studies suggest the possibility that antioxidant effect of Nrf2 may be achieved by suppression of proinflammatory pathways which are mediated by NF-κB signaling.
T7229 2388-2678 Sentence denotes Here, our results revealed that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch injury was more aggravated in cultured Nrf2 knockout astrocytes than in wildtype astrocyetes for the first time, and overexpression of these proinflammatory mediators led to more astrocytes deaths.
T7228 2290-2387 Sentence denotes Depletion of Nrf2 induces higher expression of proinflammatory mediators in brain after TBI [20].
T7227 2219-2289 Sentence denotes On the other hand, Nrf2-deficient mice appear more susceptible to TBI.
T7226 1957-2218 Sentence denotes Postinjury administration of SFN, an inducer of Nrf2, significantly improves spatial memory of rat and decreases the immunoreactivity for 4-Hydroxynonenal (4-HNE), a marker of lipid peroxidation, in the cortex and the CA3 subfield of hippocampus after TBI [19].
T7225 1740-1956 Sentence denotes Enhanced level of Nrf2 activates transcription of a group of antioxidant genes, such as heme oxygenase-1 (HO-1) and NAD (P)H: quinone oxidoreductase-1 (NQO1), which would subsequently reduce the damage in brain [18].
T7224 1653-1739 Sentence denotes Our previous study has proved the augmentation of Nrf2 in brain tissue after TBI [17].
T7223 1475-1652 Sentence denotes Nrf2-ARE pathway has been proved to be the key regulator in reducing oxidative stress, inflammatory damage, and accumulation of toxic metabolites, which are all involved in TBI.
T7222 1372-1474 Sentence denotes It is a good choice for targeting on an upstream factor to prevent such autoregulatory loop after TBI.
T7221 1251-1371 Sentence denotes This autoregulatory loop extremely aggravates the damaging effect of inflammation and induces secondary injury to brain.
T7220 1023-1250 Sentence denotes For example, TNF-α and IL-1β are potent stimulators for MMP9 in astrocytes [12, 13], and IL-6 induces overexpression of MMP9 in human colon carcinoma cells [14], and TNF-α and IL-1β also can induce activation of NF-κB [15, 16].
T7219 922-1022 Sentence denotes It has been demonstrated that there is an autoregulatory loop among these proinflammatory mediators.
T7218 733-921 Sentence denotes Our results also revealed that scratch injury induced elevation of NF-κB DNA binding activity, overexpression of MMP9, and proinflammatory mediators mentioned above in cultured astrocytes.
T7217 514-732 Sentence denotes As a transcript factor, NF-κB binds with DNA once it was activated and induces transcription of MMP9 and a battery of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6, in brain tissues after TBI [3, 10, 11].
T7216 409-513 Sentence denotes It has been demonstrated that NF-κB is activated in brain and spinal cord after traumatic injury [2, 9].
T7215 195-408 Sentence denotes Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time.
T7214 14-194 Sentence denotes The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes.
T158 0-2 Sentence denotes 4.
T159 3-13 Sentence denotes Discussion
T160 14-194 Sentence denotes The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes.
T161 195-408 Sentence denotes Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time.
T162 409-513 Sentence denotes It has been demonstrated that NF-κB is activated in brain and spinal cord after traumatic injury [2, 9].
T163 514-732 Sentence denotes As a transcript factor, NF-κB binds with DNA once it was activated and induces transcription of MMP9 and a battery of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6, in brain tissues after TBI [3, 10, 11].
T164 733-921 Sentence denotes Our results also revealed that scratch injury induced elevation of NF-κB DNA binding activity, overexpression of MMP9, and proinflammatory mediators mentioned above in cultured astrocytes.
T165 922-1022 Sentence denotes It has been demonstrated that there is an autoregulatory loop among these proinflammatory mediators.
T166 1023-1250 Sentence denotes For example, TNF-α and IL-1β are potent stimulators for MMP9 in astrocytes [12, 13], and IL-6 induces overexpression of MMP9 in human colon carcinoma cells [14], and TNF-α and IL-1β also can induce activation of NF-κB [15, 16].
T167 1251-1371 Sentence denotes This autoregulatory loop extremely aggravates the damaging effect of inflammation and induces secondary injury to brain.
T168 1372-1474 Sentence denotes It is a good choice for targeting on an upstream factor to prevent such autoregulatory loop after TBI.
T169 1475-1652 Sentence denotes Nrf2-ARE pathway has been proved to be the key regulator in reducing oxidative stress, inflammatory damage, and accumulation of toxic metabolites, which are all involved in TBI.
T170 1653-1739 Sentence denotes Our previous study has proved the augmentation of Nrf2 in brain tissue after TBI [17].
T171 1740-1956 Sentence denotes Enhanced level of Nrf2 activates transcription of a group of antioxidant genes, such as heme oxygenase-1 (HO-1) and NAD (P)H: quinone oxidoreductase-1 (NQO1), which would subsequently reduce the damage in brain [18].
T172 1957-2218 Sentence denotes Postinjury administration of SFN, an inducer of Nrf2, significantly improves spatial memory of rat and decreases the immunoreactivity for 4-Hydroxynonenal (4-HNE), a marker of lipid peroxidation, in the cortex and the CA3 subfield of hippocampus after TBI [19].
T173 2219-2289 Sentence denotes On the other hand, Nrf2-deficient mice appear more susceptible to TBI.
T174 2290-2387 Sentence denotes Depletion of Nrf2 induces higher expression of proinflammatory mediators in brain after TBI [20].
T175 2388-2678 Sentence denotes Here, our results revealed that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch injury was more aggravated in cultured Nrf2 knockout astrocytes than in wildtype astrocyetes for the first time, and overexpression of these proinflammatory mediators led to more astrocytes deaths.
T176 2679-2866 Sentence denotes Data obtained from animal studies suggest the possibility that antioxidant effect of Nrf2 may be achieved by suppression of proinflammatory pathways which are mediated by NF-κB signaling.
T177 2867-3035 Sentence denotes Administration of SFN is found to be able to inhibit IKK/IκB phosphorylation and p65 NF-κB subunit nuclear translocation, consequently alleviating NF-κB signaling [21].
T178 3036-3177 Sentence denotes And NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by diverse Nrf2 activators, such as SFN and curcumin (CUR) [22].
T179 3178-3360 Sentence denotes Furthermore, our previous studies indicate that depletion of Nrf2 induces augmentation of NF-κB activity and inflammatory response in lung, brain, and intestine after TBI [4, 5, 23].
T180 3361-3473 Sentence denotes Results from this study further confirmed such relationship existed in cultured astrocytes after scratch injury.
T181 3474-3630 Sentence denotes Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts of Nrf2-deficient mice after experimental sepsis [24].
T182 3631-3714 Sentence denotes Interestingly, it is reported that NF-κB can inhibit Nrf2 at transcriptional level.
T183 3715-3885 Sentence denotes NF-κB p65 subunit repressed the Nrf2-ARE pathway at transcriptional level by competitive interaction with the CH1-KIX domain of CBP or local histone hypoacetylation [25].
T184 3886-4066 Sentence denotes All these findings indicate the potential complicate crosstalk between NF-κB and Nrf2, which may be regulated by the upstream mitogen-activated protein kinase (MAPKs) pathway [26].
T185 4067-4158 Sentence denotes It has been confirmed that Nrf2 is mainly detected in nucleus of astrocytes after TBI [18].
T186 4159-4376 Sentence denotes In view of the fact that Nrf2 is a transcription factor which should take function mainly in nucleus, it can be reasoned that astrocytes may be one kind of respondent cells in activation of Nrf2-ARE pathway after TBI.
T187 4377-4518 Sentence denotes Previous study identified the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes after treatment with LPS or oxyhemoglobin [27, 28].
T188 4519-4672 Sentence denotes Another study revealed that after middle cerebral artery occlusion, MMP9-positive astrocytes were observed in brain tissues by immunohistochemistry [29].
T189 4673-4762 Sentence denotes Those results indicate the role of astrocytes in inflammatory process after brain injury.
T190 4763-4887 Sentence denotes But till now, there is no study focused on the relationship among astrocytes, Nrf2, and proinflammatory mediators after TBI.
T191 4888-5040 Sentence denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9 in Nrf2 knockout astrocytes after scratch injury for the first time.
T192 5041-5222 Sentence denotes In conclusion, depletion of Nrf2 induced the activation of NF-κB and the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch injury.
T193 5223-5322 Sentence denotes These results suggest that Nrf2 may be an important target for anti-inflammatory therapy after TBI.

ICD10

Id Subject Object Predicate Lexical cue
T8277 5215-5221 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8276 5014-5020 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8275 4755-4761 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8274 3466-3472 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8273 2481-2487 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8272 1355-1361 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8271 772-778 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8270 499-505 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8269 225-231 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8268 58-64 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T8288 4560-4585 http://purl.bioontology.org/ontology/ICD10/I66.9 denotes cerebral artery occlusion

simple1

Id Subject Object Predicate Lexical cue
T8356 5152-5156 Protein denotes MMP9
T8355 5142-5146 Protein denotes IL-6
T8354 5135-5140 Protein denotes IL-1β
T8353 4967-4971 Protein denotes MMP9
T8352 4957-4961 Protein denotes IL-6
T8351 4950-4955 Protein denotes IL-1β
T8350 4587-4591 Protein denotes MMP9
T8349 4439-4443 Protein denotes IL-6
T8348 4428-4433 Protein denotes IL-1β
T8347 3721-3724 Protein denotes p65
T8346 2948-2951 Protein denotes p65
T8345 2462-2466 Protein denotes MMP9
T8344 2452-2456 Protein denotes IL-6
T8343 2445-2450 Protein denotes IL-1β
T8342 1846-1850 Protein denotes HO-1
T8341 1828-1844 Protein denotes heme oxygenase-1
T8340 1199-1204 Protein denotes IL-1β
T8339 1143-1147 Protein denotes MMP9
T8338 1112-1116 Protein denotes IL-6
T8337 1079-1083 Protein denotes MMP9
T8336 1046-1051 Protein denotes IL-1β
T8335 846-850 Protein denotes MMP9
T8334 687-691 Protein denotes IL-6
T8333 676-681 Protein denotes IL-1β
T8332 610-614 Protein denotes MMP9
T8331 166-170 Protein denotes MMP9
T8330 156-160 Protein denotes IL-6
T8329 149-154 Protein denotes IL-1β

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T9937 5114-5124 Gene_expression denotes expression
T9936 5074-5081 Positive_regulation denotes induced
T9935 4929-4939 Gene_expression denotes expression
T9934 4917-4928 Positive_regulation denotes upregulated
T9933 4592-4600 Gene_expression denotes positive
T9932 4407-4417 Gene_expression denotes expression
T9931 3733-3742 Negative_regulation denotes repressed
T9930 2912-2919 Negative_regulation denotes inhibit
T9929 2974-2987 Localization denotes translocation
T9928 2497-2507 Positive_regulation denotes aggravated
T9927 2420-2434 Positive_regulation denotes overexpression
T9926 1773-1786 Transcription denotes transcription
T9925 1763-1772 Positive_regulation denotes activates
T9924 1125-1139 Positive_regulation denotes overexpression
T9923 1117-1124 Positive_regulation denotes induces
T9922 828-842 Positive_regulation denotes overexpression
T9921 828-842 Gene_expression denotes overexpression
T9920 585-592 Positive_regulation denotes induces
T9919 593-606 Transcription denotes transcription
T9918 124-138 Gene_expression denotes overexpression
T9917 65-72 Positive_regulation denotes induced
T9916 124-138 Positive_regulation denotes overexpression
T9915 5152-5156 Protein denotes MMP9
T9914 5142-5146 Protein denotes IL-6
T9913 5135-5140 Protein denotes IL-1β
T9912 4967-4971 Protein denotes MMP9
T9911 4957-4961 Protein denotes IL-6
T9910 4950-4955 Protein denotes IL-1β
T9909 4587-4591 Protein denotes MMP9
T9908 4439-4443 Protein denotes IL-6
T9907 4428-4433 Protein denotes IL-1β
T9906 3721-3724 Protein denotes p65
T9905 2948-2951 Protein denotes p65
T9904 2462-2466 Protein denotes MMP9
T9903 2452-2456 Protein denotes IL-6
T9902 2445-2450 Protein denotes IL-1β
T9901 1846-1850 Protein denotes HO-1
T9900 1828-1844 Protein denotes heme oxygenase-1
T9899 1079-1083 Protein denotes MMP9
T9898 1046-1051 Protein denotes IL-1β
T9897 1199-1204 Protein denotes IL-1β
T9896 1143-1147 Protein denotes MMP9
T9895 1112-1116 Protein denotes IL-6
T9894 846-850 Protein denotes MMP9
T9893 687-691 Protein denotes IL-6
T9892 676-681 Protein denotes IL-1β
T9891 610-614 Protein denotes MMP9
T9890 166-170 Protein denotes MMP9
T9889 156-160 Protein denotes IL-6
T9888 149-154 Protein denotes IL-1β
R8145 T9902 T9927 themeOf IL-1β,overexpression
R8146 T9888 T9918 themeOf IL-1β,overexpression
R8147 T9903 T9927 themeOf IL-6,overexpression
R8148 T9904 T9927 themeOf MMP9,overexpression
R8149 T9905 T9929 themeOf p65,translocation
R8150 T9889 T9918 themeOf IL-6,overexpression
R8151 T9906 T9931 themeOf p65,repressed
R8152 T9890 T9918 themeOf MMP9,overexpression
R8153 T9907 T9932 themeOf IL-1β,expression
R8154 T9891 T9919 themeOf MMP9,transcription
R8155 T9908 T9932 themeOf IL-6,expression
R8156 T9894 T9921 themeOf MMP9,overexpression
R8157 T9909 T9933 themeOf MMP9,positive
R8158 T9896 T9924 themeOf MMP9,overexpression
R8159 T9910 T9935 themeOf IL-1β,expression
R8160 T9900 T9926 themeOf heme oxygenase-1,transcription
R8161 T9911 T9935 themeOf IL-6,expression
R8162 T9901 T9926 themeOf HO-1,transcription
R8163 T9912 T9935 themeOf MMP9,expression
R8164 T9913 T9937 themeOf IL-1β,expression
R8165 T9914 T9937 themeOf IL-6,expression
R8166 T9915 T9937 themeOf MMP9,expression
R8167 T9916 T9917 themeOf overexpression,induced
R8168 T9916 T9917 themeOf overexpression,induced
R8169 T9916 T9917 themeOf overexpression,induced
R8170 T9918 T9917 themeOf overexpression,induced
R8171 T9918 T9917 themeOf overexpression,induced
R8172 T9918 T9917 themeOf overexpression,induced
R8173 T9918 T9916 themeOf overexpression,overexpression
R8174 T9918 T9916 themeOf overexpression,overexpression
R8175 T9918 T9916 themeOf overexpression,overexpression
R8176 T9919 T9920 themeOf transcription,induces
R8177 T9921 T9922 themeOf overexpression,overexpression
R8181 T9924 T9923 themeOf overexpression,induces
R8183 T9926 T9925 themeOf transcription,activates
R8185 T9926 T9925 themeOf transcription,activates
R8186 T9927 T9928 themeOf overexpression,aggravated
R8190 T9927 T9928 themeOf overexpression,aggravated
R8191 T9927 T9928 themeOf overexpression,aggravated
R8193 T9929 T9930 themeOf translocation,inhibit
R8194 T9935 T9934 themeOf expression,upregulated
R8199 T9935 T9934 themeOf expression,upregulated
R8201 T9935 T9934 themeOf expression,upregulated
R8202 T9937 T9936 themeOf expression,induced
R8205 T9937 T9936 themeOf expression,induced
R8206 T9937 T9936 themeOf expression,induced

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T8494 5074-5081 Positive_regulation denotes induced
T8493 5114-5124 Gene_expression denotes expression
T8492 5056-5065 Negative_regulation denotes depletion
T8491 4917-4928 Positive_regulation denotes upregulated
T8490 4929-4939 Gene_expression denotes expression
T8489 4592-4600 Gene_expression denotes positive
T8488 4407-4417 Gene_expression denotes expression
T8487 3804-3815 Binding denotes interaction
T8486 3733-3742 Negative_regulation denotes repressed
T8485 2912-2919 Negative_regulation denotes inhibit
T8484 2974-2987 Localization denotes translocation
T8483 2497-2507 Positive_regulation denotes aggravated
T8482 2420-2434 Positive_regulation denotes overexpression
T8481 1763-1772 Positive_regulation denotes activates
T8480 1773-1786 Transcription denotes transcription
T8479 1117-1124 Positive_regulation denotes induces
T8478 1125-1139 Positive_regulation denotes overexpression
T8477 828-842 Positive_regulation denotes overexpression
T8476 779-786 Positive_regulation denotes induced
T8475 585-592 Positive_regulation denotes induces
T8474 593-606 Transcription denotes transcription
T8473 124-138 Positive_regulation denotes overexpression
T8472 65-72 Positive_regulation denotes induced
T8471 5152-5156 Protein denotes MMP9
T8470 5142-5146 Protein denotes IL-6
T8469 5135-5140 Protein denotes IL-1β
T8468 4967-4971 Protein denotes MMP9
T8467 4957-4961 Protein denotes IL-6
T8466 4950-4955 Protein denotes IL-1β
T8465 4587-4591 Protein denotes MMP9
T8464 4439-4443 Protein denotes IL-6
T8463 4428-4433 Protein denotes IL-1β
T8462 3721-3724 Protein denotes p65
T8454 1046-1051 Protein denotes IL-1β
T8453 1199-1204 Protein denotes IL-1β
T8452 1143-1147 Protein denotes MMP9
T8451 1112-1116 Protein denotes IL-6
T8450 846-850 Protein denotes MMP9
T8449 687-691 Protein denotes IL-6
T8448 676-681 Protein denotes IL-1β
T8447 610-614 Protein denotes MMP9
T8446 166-170 Protein denotes MMP9
T8445 156-160 Protein denotes IL-6
T8444 149-154 Protein denotes IL-1β
T8461 2948-2951 Protein denotes p65
T8460 2462-2466 Protein denotes MMP9
T8459 2452-2456 Protein denotes IL-6
T8458 2445-2450 Protein denotes IL-1β
T8457 1846-1850 Protein denotes HO-1
T8456 1828-1844 Protein denotes heme oxygenase-1
T8455 1079-1083 Protein denotes MMP9
R6868 T8444 T8473 themeOf IL-1β,overexpression
R6869 T8445 T8473 themeOf IL-6,overexpression
R6870 T8446 T8472 themeOf MMP9,induced
R6871 T8446 T8473 themeOf MMP9,overexpression
R6872 T8447 T8474 themeOf MMP9,transcription
R6873 T8450 T8477 themeOf MMP9,overexpression
R6874 T8450 T8476 themeOf MMP9,induced
R6875 T8452 T8478 themeOf MMP9,overexpression
R6876 T8456 T8480 themeOf heme oxygenase-1,transcription
R6877 T8457 T8480 themeOf HO-1,transcription
R6878 T8458 T8483 themeOf IL-1β,aggravated
R6879 T8458 T8482 themeOf IL-1β,overexpression
R6880 T8459 T8482 themeOf IL-6,overexpression
R6881 T8460 T8483 themeOf MMP9,aggravated
R6882 T8460 T8482 themeOf MMP9,overexpression
R6883 T8461 T8484 themeOf p65,translocation
R6884 T8462 T8487 themeOf p65,interaction
R6885 T8462 T8486 themeOf p65,repressed
R6886 T8463 T8488 themeOf IL-1β,expression
R6887 T8464 T8488 themeOf IL-6,expression
R6888 T8465 T8489 themeOf MMP9,positive
R6889 T8466 T8490 themeOf IL-1β,expression
R6890 T8467 T8490 themeOf IL-6,expression
R6891 T8468 T8490 themeOf MMP9,expression
R6892 T8469 T8493 themeOf IL-1β,expression
R6893 T8470 T8493 themeOf IL-6,expression
R6894 T8471 T8493 themeOf MMP9,expression
R6895 T8473 T8472 themeOf overexpression,induced
R6896 T8473 T8472 themeOf overexpression,induced
R6897 T8473 T8472 themeOf overexpression,induced
R6898 T8474 T8475 themeOf transcription,induces
R6899 T8478 T8479 themeOf overexpression,induces
R6900 T8480 T8481 themeOf transcription,activates
R6901 T8480 T8481 themeOf transcription,activates
R6902 T8482 T8483 themeOf overexpression,aggravated
R6903 T8482 T8483 themeOf overexpression,aggravated
R6904 T8482 T8483 themeOf overexpression,aggravated
R6905 T8484 T8485 themeOf translocation,inhibit
R6906 T8490 T8491 themeOf expression,upregulated
R6907 T8490 T8491 themeOf expression,upregulated
R6908 T8490 T8491 themeOf expression,upregulated
R6909 T8493 T8494 themeOf expression,induced
R6910 T8493 T8494 themeOf expression,induced
R6911 T8493 T8494 themeOf expression,induced
R6912 T8494 T8492 themeOf induced,depletion
R6913 T8494 T8492 themeOf induced,depletion
R6914 T8494 T8492 themeOf induced,depletion

DLUT931

Id Subject Object Predicate Lexical cue
T8443 5086-5096 Positive_regulation denotes activation
T8442 5114-5124 Gene_expression denotes expression
T8441 4917-4928 Positive_regulation denotes upregulated
T8440 4929-4939 Gene_expression denotes expression
T8439 4592-4600 Gene_expression denotes positive
T8438 4407-4417 Gene_expression denotes expression
T8437 3733-3742 Negative_regulation denotes repressed
T8436 3804-3815 Binding denotes interaction
T8435 2912-2919 Negative_regulation denotes inhibit
T8434 2974-2987 Localization denotes translocation
T8433 2497-2507 Positive_regulation denotes aggravated
T8432 2420-2434 Positive_regulation denotes overexpression
T8431 1763-1772 Positive_regulation denotes activates
T8430 1773-1786 Transcription denotes transcription
T8429 1117-1124 Positive_regulation denotes induces
T8428 1125-1139 Positive_regulation denotes overexpression
T8427 779-786 Positive_regulation denotes induced
T8426 828-842 Positive_regulation denotes overexpression
T8425 585-592 Positive_regulation denotes induces
T8424 593-606 Transcription denotes transcription
T8423 77-89 Positive_regulation denotes upregulation
T8422 65-72 Positive_regulation denotes induced
T8421 124-138 Gene_expression denotes overexpression
T8420 5152-5156 Protein denotes MMP9
T8419 5142-5146 Protein denotes IL-6
T8418 5135-5140 Protein denotes IL-1β
T8417 4967-4971 Protein denotes MMP9
T8416 4957-4961 Protein denotes IL-6
T8415 4950-4955 Protein denotes IL-1β
T8414 4587-4591 Protein denotes MMP9
T8413 4439-4443 Protein denotes IL-6
T8412 4428-4433 Protein denotes IL-1β
T8411 3721-3724 Protein denotes p65
T8410 2948-2951 Protein denotes p65
T8409 2462-2466 Protein denotes MMP9
T8408 2452-2456 Protein denotes IL-6
T8407 2445-2450 Protein denotes IL-1β
T8406 1846-1850 Protein denotes HO-1
T8405 1828-1844 Protein denotes heme oxygenase-1
T8404 1079-1083 Protein denotes MMP9
T8403 1046-1051 Protein denotes IL-1β
T8402 1199-1204 Protein denotes IL-1β
T8401 1143-1147 Protein denotes MMP9
T8400 1112-1116 Protein denotes IL-6
T8399 846-850 Protein denotes MMP9
T8398 687-691 Protein denotes IL-6
T8397 676-681 Protein denotes IL-1β
T8396 610-614 Protein denotes MMP9
T8395 166-170 Protein denotes MMP9
T8394 156-160 Protein denotes IL-6
T8393 149-154 Protein denotes IL-1β
R6832 T8411 T8436 themeOf p65,interaction
R6833 T8412 T8438 themeOf IL-1β,expression
R6835 T8414 T8439 themeOf MMP9,positive
R6836 T8415 T8440 themeOf IL-1β,expression
R6839 T8418 T8442 themeOf IL-1β,expression
R6842 T8421 T8422 themeOf overexpression,induced
R6843 T8421 T8423 themeOf overexpression,upregulation
R6844 T8421 T8422 themeOf overexpression,induced
R6845 T8421 T8422 themeOf overexpression,induced
R6846 T8421 T8423 themeOf overexpression,upregulation
R6847 T8421 T8423 themeOf overexpression,upregulation
R6848 T8423 T8422 themeOf upregulation,induced
R6849 T8423 T8422 themeOf upregulation,induced
R6850 T8423 T8422 themeOf upregulation,induced
R6851 T8424 T8425 themeOf transcription,induces
R6852 T8424 T8425 themeOf transcription,induces
R6853 T8426 T8427 themeOf overexpression,induced
R6854 T8428 T8429 themeOf overexpression,induces
R6855 T8430 T8431 themeOf transcription,activates
R6856 T8430 T8431 themeOf transcription,activates
R6857 T8432 T8433 themeOf overexpression,aggravated
R6860 T8434 T8435 themeOf translocation,inhibit
R6861 T8436 T8437 themeOf interaction,repressed
R6862 T8440 T8441 themeOf expression,upregulated
R6865 T8442 T8443 themeOf expression,activation
R6818 T8393 T8421 themeOf IL-1β,overexpression
R6819 T8394 T8421 themeOf IL-6,overexpression
R6820 T8395 T8421 themeOf MMP9,overexpression
R6821 T8396 T8424 themeOf MMP9,transcription
R6822 T8398 T8424 themeOf IL-6,transcription
R6823 T8399 T8426 themeOf MMP9,overexpression
R6824 T8400 T8429 causeOf IL-6,induces
R6825 T8401 T8428 themeOf MMP9,overexpression
R6826 T8405 T8430 themeOf heme oxygenase-1,transcription
R6827 T8406 T8430 themeOf HO-1,transcription
R6828 T8407 T8432 themeOf IL-1β,overexpression
R6829 T8408 T8432 themeOf IL-6,overexpression
R6831 T8410 T8434 themeOf p65,translocation
R6830 T8409 T8432 themeOf MMP9,overexpression
R6834 T8413 T8438 themeOf IL-6,expression
R6837 T8416 T8440 themeOf IL-6,expression
R6838 T8417 T8440 themeOf MMP9,expression
R6858 T8432 T8433 themeOf overexpression,aggravated
R6859 T8432 T8433 themeOf overexpression,aggravated
R6863 T8440 T8441 themeOf expression,upregulated
R6840 T8419 T8442 themeOf IL-6,expression
R6841 T8420 T8442 themeOf MMP9,expression
R6864 T8440 T8441 themeOf expression,upregulated
R6866 T8442 T8443 themeOf expression,activation
R6867 T8442 T8443 themeOf expression,activation

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Speculation
T10101 4403-4466 Gene_expression denotes the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes
T10100 4403-4466 Gene_expression denotes the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes
T10099 4403-4466 Gene_expression denotes the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes
T10098 1125-1147 Positive_regulation denotes overexpression of MMP9
T10097 1125-1147 Gene_expression denotes overexpression of MMP9
T10096 217-317 Positive_regulation denotes scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines
T10095 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10094 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10093 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10092 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10091 73-119 Positive_regulation denotes the upregulation of NF-κB DNA binding activity
T10090 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T10089 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T10088 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T10087 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T10086 3661-3713 Negative_regulation denotes that NF-κB can inhibit Nrf2 at transcriptional level true
T10085 2847-2865 Positive_regulation denotes by NF-κB signaling
T10084 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10083 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10082 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10081 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10080 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10079 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10078 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10077 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10076 3014-3029 Positive_regulation denotes NF-κB signaling
T10075 434-505 Positive_regulation denotes that NF-κB is activated in brain and spinal cord after traumatic injury
T10074 278-317 Gene_expression denotes expression of proinflammatory cytokines
T10073 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10072 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10071 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10039 2300-2307 Protein denotes of Nrf2
T10038 3040-3115 Protein denotes NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by
T10037 843-851 Protein denotes of MMP9,
T10036 369-407 Entity denotes wildtype astrocytes for the first time
T10035 901-920 Entity denotes cultured astrocytes
T10034 538-543 Protein denotes NF-κB
T10033 4705-4718 Entity denotes of astrocytes
T10032 4989-4999 Entity denotes astrocytes
T10031 2445-2450 Protein denotes IL-1β
T10030 1700-1723 Protein denotes of Nrf2 in brain tissue
T10029 4179-4188 Protein denotes that Nrf2
T10028 4967-4971 Protein denotes MMP9
T10027 669-674 Protein denotes TNF-α
T10026 4957-4961 Protein denotes IL-6
T10025 5250-5254 Protein denotes Nrf2
T10024 2462-2480 Protein denotes MMP9 after scratch
T10023 3594-3629 Protein denotes mice after experimental sepsis [24]
T10022 5152-5156 Protein denotes MMP9
T10021 1846-1850 Protein denotes HO-1
T10020 1600-1620 Entity denotes of toxic metabolites
T10019 4121-4142 Entity denotes nucleus of astrocytes
T10018 4421-4426 Protein denotes TNF-α
T10017 5135-5140 Protein denotes IL-1β
T10016 1828-1898 Entity denotes heme oxygenase-1 (HO-1) and NAD (P)H: quinone oxidoreductase-1 (NQO1),
T10015 1232-1240 Protein denotes of NF-κB
T10014 289-317 Protein denotes of proinflammatory cytokines
T10013 3268-3273 Protein denotes NF-κB
T10012 3088-3091 Entity denotes LPS
T10011 3684-3688 Protein denotes Nrf2
T10010 4132-4142 Entity denotes astrocytes
T10009 156-160 Protein denotes IL-6
T10008 149-154 Protein denotes IL-1β
T10007 2452-2456 Protein denotes IL-6
T10006 2761-2768 Protein denotes of Nrf2
T10005 1986-1990 Protein denotes SFN,
T10004 4192-4259 Protein denotes a transcription factor which should take function mainly in nucleus
T10003 2885-2888 Protein denotes SFN
T10002 550-558 Entity denotes with DNA
T10001 3065-3092 Entity denotes by lipopolysaccharide (LPS)
T10000 2238-2257 Protein denotes Nrf2-deficient mice
T9999 3666-3671 Protein denotes NF-κB
T9998 3129-3139 Entity denotes activators
T9997 4439-4443 Protein denotes IL-6
T9996 800-851 Protein denotes NF-κB DNA binding activity, overexpression of MMP9,
T9995 1801-1812 Entity denotes antioxidant
T9994 4046-4051 Protein denotes MAPKs
T9993 4587-4591 Protein denotes MMP9
T9992 2175-2178 Protein denotes CA3
T9991 3856-3863 Entity denotes histone
T9990 174-193 Entity denotes cultured astrocytes
T9989 5128-5133 Protein denotes TNF-α
T9988 1866-1888 Protein denotes quinone oxidoreductase
T9987 3715-3732 Protein denotes NF-κB p65 subunit
T9986 4428-4433 Protein denotes IL-1β
T9985 2948-2951 Protein denotes p65
T9984 687-691 Protein denotes IL-6
T9983 1189-1194 Protein denotes TNF-α
T9982 3967-3972 Protein denotes Nrf2,
T9981 1199-1204 Protein denotes IL-1β
T9980 2525-2544 Entity denotes knockout astrocytes
T9979 1046-1051 Protein denotes IL-1β
T9978 3829-3832 Entity denotes KIX
T9977 3149-3152 Protein denotes SFN
T9976 4841-4845 Protein denotes Nrf2
T9975 3843-3846 Protein denotes CBP
T9974 142-147 Protein denotes TNF-α
T9973 4447-4466 Entity denotes cultured astrocytes
T9972 3494-3502 Protein denotes of NF-κB
T9971 2652-2677 Entity denotes to more astrocytes deaths
T9970 4950-4955 Protein denotes IL-1β
T9969 3996-4065 Protein denotes by the upstream mitogen-activated protein kinase (MAPKs) pathway [26]
T9968 1801-1819 Protein denotes antioxidant genes,
T9967 93-98 Protein denotes NF-κB
T9966 3432-3451 Entity denotes cultured astrocytes
T9965 166-170 Protein denotes MMP9
T9964 4943-4948 Protein denotes TNF-α
T9963 3957-3962 Protein denotes NF-κB
T9962 1112-1116 Protein denotes IL-6
T9961 5190-5200 Entity denotes astrocytes
T9960 607-614 Protein denotes of MMP9
T9959 4495-4508 Entity denotes oxyhemoglobin
T9958 3014-3019 Protein denotes NF-κB
T9957 1140-1147 Protein denotes of MMP9
T9956 2850-2855 Protein denotes NF-κB
T9955 1861-1862 Entity denotes P
T9954 3531-3542 Entity denotes macrophages
T9953 1087-1102 Entity denotes astrocytes [12,
T9952 517-529 Protein denotes a transcript
T9951 4829-4846 Entity denotes astrocytes, Nrf2,
T9950 5142-5146 Protein denotes IL-6
T9949 3816-3839 Entity denotes with the CH1-KIX domain
T9948 676-681 Protein denotes IL-1β
T9947 434-444 Protein denotes that NF-κB
T9946 2438-2443 Protein denotes TNF-α
T9945 2948-2987 Protein denotes p65 NF-κB subunit nuclear translocation
T9944 3715-3720 Protein denotes NF-κB
T9943 4326-4375 Entity denotes cells in activation of Nrf2-ARE pathway after TBI
T9942 256-264 Protein denotes of NF-κB
T9941 1079-1083 Protein denotes MMP9
T9940 648-691 Protein denotes cytokines, including TNF-α, IL-1β, and IL-6
T9939 4285-4295 Entity denotes astrocytes
T9938 4592-4611 Entity denotes positive astrocytes
T10070 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10069 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10068 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10067 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10066 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10065 1700-1724 Localization denotes of Nrf2 in brain tissue
T10064 593-614 Transcription denotes transcription of MMP9
T10063 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10062 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10061 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10060 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10059 3474-3575 Positive_regulation denotes Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts
T10058 1587-1620 Binding denotes accumulation of toxic metabolites
T10057 3040-3115 Negative_regulation denotes NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by true
T10056 3474-3502 Positive_regulation denotes Enhanced activation of NF-κB
T10055 1221-1249 Positive_regulation denotes activation of NF-κB [15, 16]
T10054 538-580 Binding denotes NF-κB binds with DNA once it was activated
T10053 5082-5105 Protein denotes the activation of NF-κB
T10052 1892-1896 Protein denotes NQO1
T10051 3157-3171 Entity denotes curcumin (CUR)
T10050 344-354 Entity denotes astrocytes
T10049 1856-1863 Entity denotes NAD (P)
T10048 3548-3575 Entity denotes mouse embryonic fibroblasts
T10047 4488-4491 Entity denotes LPS
T10046 5286-5321 Entity denotes anti-inflammatory therapy after TBI
T10045 4252-4259 Entity denotes nucleus
T10044 2133-2138 Entity denotes lipid
T10043 4094-4098 Protein denotes Nrf2
T10042 1036-1041 Protein denotes TNF-α
T10041 2742-2753 Entity denotes antioxidant
T10040 1828-1851 Protein denotes heme oxygenase-1 (HO-1)
R8178 T9946 T10077 themeOf TNF-α,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8179 T9946 T10084 themeOf TNF-α,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8180 T9947 T10075 themeOf that NF-κB,that NF-κB is activated in brain and spinal cord after traumatic injury
R8182 T9950 T10087 themeOf IL-6,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8184 T9956 T10085 causeOf NF-κB,by NF-κB signaling
R8187 T9957 T10097 themeOf of MMP9,overexpression of MMP9
R8188 T9957 T10098 themeOf of MMP9,overexpression of MMP9
R8189 T9958 T10076 causeOf NF-κB,NF-κB signaling
R8192 T9960 T10064 themeOf of MMP9,transcription of MMP9
R8195 T9964 T10062 themeOf TNF-α,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8196 T9965 T10066 themeOf MMP9,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8197 T9965 T10071 themeOf MMP9,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8198 T9970 T10061 themeOf IL-1β,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8200 T9972 T10059 themeOf of NF-κB,"Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts"
R8203 T9974 T10070 themeOf TNF-α,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8204 T9974 T10073 themeOf TNF-α,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8207 T10014 T10074 themeOf of proinflammatory cytokines,expression of proinflammatory cytokines
R8208 T10015 T10055 themeOf of NF-κB,"activation of NF-κB [15, 16]"
R8209 T9986 T10101 themeOf IL-1β,"the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes"
R8210 T10017 T10090 themeOf IL-1β,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8211 T9989 T10088 themeOf TNF-α,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8212 T10018 T10099 themeOf TNF-α,"the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes"
R8213 T10022 T10089 themeOf MMP9,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8214 T9997 T10100 themeOf IL-6,"the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes"
R8215 T10024 T10079 themeOf MMP9 after scratch,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8216 T9999 T10086 causeOf NF-κB,that NF-κB can inhibit Nrf2 at transcriptional level
R8217 T10024 T10081 themeOf MMP9 after scratch,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8218 T10002 T10054 themeOf with DNA,NF-κB binds with DNA once it was activated
R8219 T10026 T10060 themeOf IL-6,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8220 T10028 T10063 themeOf MMP9,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8221 T10007 T10078 themeOf IL-6,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8222 T10007 T10082 themeOf IL-6,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8223 T10008 T10067 themeOf IL-1β,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8224 T10008 T10069 themeOf IL-1β,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8225 T10009 T10068 themeOf IL-6,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8226 T10009 T10072 themeOf IL-6,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8227 T10011 T10086 themeOf Nrf2,that NF-κB can inhibit Nrf2 at transcriptional level
R8228 T10030 T10065 themeOf of Nrf2 in brain tissue,of Nrf2 in brain tissue
R8229 T10031 T10080 themeOf IL-1β,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8230 T10031 T10083 themeOf IL-1β,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8231 T10034 T10054 themeOf NF-κB,NF-κB binds with DNA once it was activated
R8232 T10038 T10057 causeOf NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by,NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by
R8233 T10059 T10056 themeOf "Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts",Enhanced activation of NF-κB
R8234 T10060 T10094 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8235 T10061 T10095 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8236 T10062 T10092 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8237 T10063 T10093 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8238 T10074 T10096 themeOf expression of proinflammatory cytokines,scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T9677 5321-5322 . denotes .
T9676 5318-5321 NNP denotes TBI
T9675 5312-5317 IN denotes after
T9674 5304-5311 NN denotes therapy
T9673 5286-5303 JJ denotes anti-inflammatory
T9672 5282-5285 IN denotes for
T9671 5275-5281 NN denotes target
T9670 5265-5274 JJ denotes important
T9669 5262-5264 DT denotes an
T9668 5259-5261 VB denotes be
T9667 5255-5258 MD denotes may
T9666 5250-5254 NNP denotes Nrf2
T9665 5245-5249 IN denotes that
T9664 5237-5244 VBP denotes suggest
T9663 5229-5236 NNS denotes results
T9662 5223-5228 DT denotes These
T9661 5221-5222 . denotes .
T9660 5215-5221 NN denotes injury
T9659 5207-5214 NN denotes scratch
T9658 5201-5206 IN denotes after
T9657 5190-5200 NNS denotes astrocytes
T9656 5187-5189 IN denotes in
T9655 5180-5186 NNS denotes deaths
T9654 5175-5179 NN denotes cell
T9653 5170-5174 JJR denotes more
T9652 5167-5169 IN denotes in
T9651 5157-5166 VBG denotes resulting
T9650 5152-5156 NNP denotes MMP9
T9649 5148-5151 CC denotes and
T9648 5146-5147 , denotes ,
T9647 5142-5146 NNP denotes IL-6
T9646 5140-5141 , denotes ,
T9645 5135-5140 NNP denotes IL-1β
T9644 5133-5134 , denotes ,
T9643 5128-5133 NNP denotes TNF-α
T9642 5125-5127 IN denotes of
T9641 5114-5124 NN denotes expression
T9640 5110-5113 DT denotes the
T9639 5106-5109 CC denotes and
T9638 5100-5105 NNP denotes NF-κB
T9637 5097-5099 IN denotes of
T9636 5086-5096 NN denotes activation
T9635 5082-5085 DT denotes the
T9634 5074-5081 VBD denotes induced
T9439 3983-3985 VB denotes be
T9438 3979-3982 MD denotes may
T9437 3973-3978 WDT denotes which
T9436 3971-3972 , denotes ,
T9435 3967-3971 NNP denotes Nrf2
T9434 3963-3966 CC denotes and
T9433 3957-3962 NNP denotes NF-κB
T9432 3949-3956 IN denotes between
T9431 3939-3948 NN denotes crosstalk
T9430 3928-3938 VBP denotes complicate
T9429 3918-3927 JJ denotes potential
T9428 3914-3917 DT denotes the
T9427 3905-3913 VBP denotes indicate
T9426 3896-3904 NNS denotes findings
T9425 3890-3895 DT denotes these
T9424 3886-3889 PDT denotes All
T9423 3884-3885 . denotes .
T9422 3883-3884 NNP denotes ]
T9421 3881-3883 CD denotes 25
T9420 3880-3881 NNP denotes [
T9419 3864-3879 NN denotes hypoacetylation
T9418 3856-3863 NN denotes histone
T9417 3850-3855 JJ denotes local
T9416 3847-3849 CC denotes or
T9415 3843-3846 NNP denotes CBP
T9414 3840-3842 IN denotes of
T9413 3833-3839 NN denotes domain
T9412 3825-3832 NNP denotes CH1-KIX
T9410 3816-3820 IN denotes with
T9409 3804-3815 NN denotes interaction
T9408 3792-3803 JJ denotes competitive
T9407 3789-3791 IN denotes by
T9406 3783-3788 NN denotes level
T9405 3767-3782 JJ denotes transcriptional
T9404 3764-3766 IN denotes at
T9403 3756-3763 NN denotes pathway
T9402 3747-3755 JJ denotes Nrf2-ARE
T9401 3743-3746 DT denotes the
T9400 3733-3742 VBD denotes repressed
T9399 3725-3732 NN denotes subunit
T9398 3721-3724 CD denotes p65
T9397 3715-3720 NNP denotes NF-κB
T9396 3713-3714 . denotes .
T9395 3708-3713 NN denotes level
T9394 3692-3707 JJ denotes transcriptional
T9393 3689-3691 IN denotes at
T9392 3684-3688 NNP denotes Nrf2
T9391 3676-3683 VB denotes inhibit
T9390 3672-3675 MD denotes can
T9389 3666-3671 NNP denotes NF-κB
T9388 3661-3665 IN denotes that
T9387 3652-3660 VBN denotes reported
T9386 3649-3651 VBZ denotes is
T9385 3646-3648 PRP denotes it
T9384 3644-3645 , denotes ,
T9383 3631-3644 RB denotes Interestingly
T9382 3629-3630 . denotes .
T9381 3628-3629 NNP denotes ]
T9380 3626-3628 CD denotes 24
T9379 3625-3626 NNP denotes [
T9378 3618-3624 NN denotes sepsis
T9377 3605-3617 JJ denotes experimental
T9376 3599-3604 IN denotes after
T9375 3594-3598 NNS denotes mice
T9374 3579-3593 JJ denotes Nrf2-deficient
T9373 3576-3578 IN denotes of
T9372 3564-3575 NNS denotes fibroblasts
T9371 3554-3563 JJ denotes embryonic
T9370 3548-3553 NN denotes mouse
T9369 3544-3547 CC denotes and
T9368 3542-3543 , denotes ,
T9367 3531-3542 NNS denotes macrophages
T9366 3529-3530 , denotes ,
T9365 3525-3529 NN denotes lung
T9364 3522-3524 IN denotes in
T9363 3511-3521 VBN denotes discovered
T9362 3506-3510 RB denotes also
T9361 3503-3505 VBZ denotes is
T9360 3497-3502 NNP denotes NF-κB
T9359 3494-3496 IN denotes of
T9358 3483-3493 NN denotes activation
T9357 3474-3482 VBN denotes Enhanced
T9356 3472-3473 . denotes .
T9355 3466-3472 NN denotes injury
T9354 3458-3465 NN denotes scratch
T9353 3452-3457 IN denotes after
T9352 3441-3451 NNS denotes astrocytes
T9351 3432-3440 JJ denotes cultured
T9350 3429-3431 IN denotes in
T9349 3421-3428 VBD denotes existed
T9348 3408-3420 NN denotes relationship
T9347 3403-3407 JJ denotes such
T9346 3393-3402 VBD denotes confirmed
T9345 3385-3392 JJ denotes further
T9344 3379-3384 NN denotes study
T9343 3374-3378 DT denotes this
T9342 3369-3373 IN denotes from
T9341 3361-3368 NNS denotes Results
T9340 3359-3360 . denotes .
T9339 3358-3359 NNP denotes ]
T9338 3356-3358 CD denotes 23
T9337 3354-3355 , denotes ,
T9336 3353-3354 CD denotes 5
T9335 3351-3352 , denotes ,
T9334 3350-3351 CD denotes 4
T9333 3349-3350 NNP denotes [
T9332 3345-3348 NNP denotes TBI
T9331 3339-3344 IN denotes after
T9330 3329-3338 JJ denotes intestine
T9329 3325-3328 CC denotes and
T9328 3323-3324 , denotes ,
T9327 3318-3323 NN denotes brain
T9326 3316-3317 , denotes ,
T9325 3312-3316 NN denotes lung
T9324 3309-3311 IN denotes in
T9323 3300-3308 NN denotes response
T9322 3287-3299 JJ denotes inflammatory
T9321 3283-3286 CC denotes and
T9320 3274-3282 NN denotes activity
T9319 3268-3273 JJ denotes NF-κB
T9318 3265-3267 IN denotes of
T9317 3252-3264 NN denotes augmentation
T9316 3244-3251 VBZ denotes induces
T9315 3239-3243 JJ denotes Nrf2
T9314 3236-3238 IN denotes of
T9313 3226-3235 NN denotes depletion
T9312 3221-3225 IN denotes that
T9311 3212-3220 VBP denotes indicate
T9310 3204-3211 NNS denotes studies
T9309 3195-3203 JJ denotes previous
T9308 3191-3194 PRP$ denotes our
T9307 3189-3190 , denotes ,
T9306 3178-3189 RB denotes Furthermore
T9305 3176-3177 . denotes .
T9304 3175-3176 NNP denotes ]
T9303 3173-3175 CD denotes 22
T9302 3172-3173 NNP denotes [
T9301 3170-3171 -RRB- denotes )
T9300 3167-3170 NNP denotes CUR
T9299 3166-3167 -LRB- denotes (
T9298 3157-3165 NN denotes curcumin
T9297 3153-3156 CC denotes and
T9296 3149-3152 NNP denotes SFN
T9295 3146-3148 IN denotes as
T9294 3141-3145 JJ denotes such
T9293 3139-3140 , denotes ,
T9292 3129-3139 NNS denotes activators
T9291 3124-3128 JJ denotes Nrf2
T9290 3116-3123 JJ denotes diverse
T9289 3113-3115 IN denotes by
T9288 3102-3112 VBN denotes attenuated
T9287 3099-3101 VB denotes be
T9286 3093-3098 MD denotes could
T9285 3091-3092 -RRB- denotes )
T9284 3088-3091 NNP denotes LPS
T9283 3087-3088 -LRB- denotes (
T9282 3068-3086 NN denotes lipopolysaccharide
T9281 3065-3067 IN denotes by
T9280 3057-3064 VBN denotes induced
T9279 3046-3056 NN denotes activation
T9278 3040-3045 JJ denotes NF-κB
T9277 3036-3039 CC denotes And
T9276 3034-3035 . denotes .
T9275 3033-3034 NNP denotes ]
T9274 3031-3033 CD denotes 21
T9273 3030-3031 NNP denotes [
T9272 3020-3029 VBG denotes signaling
T9271 3014-3019 JJ denotes NF-κB
T9270 3002-3013 VBG denotes alleviating
T9269 2989-3001 RB denotes consequently
T9268 2987-2988 , denotes ,
T9267 2974-2987 NN denotes translocation
T9266 2966-2973 JJ denotes nuclear
T9265 2958-2965 NN denotes subunit
T9264 2952-2957 JJ denotes NF-κB
T9263 2948-2951 CD denotes p65
T9262 2944-2947 CC denotes and
T9261 2928-2943 NN denotes phosphorylation
T9260 2925-2927 NNP denotes κB
T9259 2920-2925 NNP denotes IKK/I
T9258 2912-2919 VB denotes inhibit
T9257 2909-2911 TO denotes to
T9256 2904-2908 JJ denotes able
T9255 2901-2903 VB denotes be
T9254 2898-2900 TO denotes to
T9253 2892-2897 VBN denotes found
T9252 2889-2891 VBZ denotes is
T9251 2885-2888 NNP denotes SFN
T9250 2882-2884 IN denotes of
T9249 2867-2881 NNP denotes Administration
T9248 2865-2866 . denotes .
T9247 2856-2865 VBG denotes signaling
T9246 2850-2855 JJ denotes NF-κB
T9245 2847-2849 IN denotes by
T9244 2838-2846 VBN denotes mediated
T9243 2834-2837 VBP denotes are
T9242 2828-2833 WDT denotes which
T9241 2819-2827 NNS denotes pathways
T9240 2803-2818 JJ denotes proinflammatory
T9239 2800-2802 IN denotes of
T9238 2788-2799 NN denotes suppression
T9237 2785-2787 IN denotes by
T9236 2776-2784 VBN denotes achieved
T9235 2773-2775 VB denotes be
T9234 2769-2772 MD denotes may
T9233 2764-2768 NNP denotes Nrf2
T9232 2761-2763 IN denotes of
T9231 2754-2760 NN denotes effect
T9230 2742-2753 JJ denotes antioxidant
T9229 2737-2741 WDT denotes that
T9228 2725-2736 NN denotes possibility
T9227 2721-2724 DT denotes the
T9226 2713-2720 VBP denotes suggest
T9225 2705-2712 NNS denotes studies
T9224 2698-2704 JJ denotes animal
T9114 2070-2073 DT denotes the
T9113 2060-2069 VBZ denotes decreases
T9112 2056-2059 CC denotes and
T9111 2052-2055 NN denotes rat
T9110 2049-2051 IN denotes of
T9109 2042-2048 NN denotes memory
T9108 2034-2041 JJ denotes spatial
T9107 2025-2033 VBZ denotes improves
T9106 2011-2024 RB denotes significantly
T9105 2009-2010 , denotes ,
T9104 2005-2009 NNP denotes Nrf2
T9103 2002-2004 IN denotes of
T9102 1994-2001 NN denotes inducer
T9101 1991-1993 DT denotes an
T9100 1989-1990 , denotes ,
T9099 1986-1989 NNP denotes SFN
T9098 1983-1985 IN denotes of
T9097 1968-1982 NN denotes administration
T9096 1957-1967 NNP denotes Postinjury
T9095 1955-1956 . denotes .
T9094 1954-1955 NNP denotes ]
T9093 1952-1954 CD denotes 18
T9092 1951-1952 NNP denotes [
T9091 1945-1950 NN denotes brain
T9090 1942-1944 IN denotes in
T9089 1935-1941 NN denotes damage
T9088 1931-1934 DT denotes the
T9087 1924-1930 VB denotes reduce
T9086 1911-1923 RB denotes subsequently
T9085 1905-1910 MD denotes would
T9084 1899-1904 WDT denotes which
T9083 1897-1898 , denotes ,
T9082 1896-1897 -RRB- denotes )
T9081 1892-1896 CD denotes NQO1
T9080 1891-1892 -LRB- denotes (
T9079 1874-1890 JJ denotes oxidoreductase-1
T9078 1866-1873 VB denotes quinone
T9077 1864-1865 : denotes :
T9076 1863-1864 NNP denotes H
T9075 1862-1863 -RRB- denotes )
T9074 1861-1862 NNP denotes P
T9073 1860-1861 -LRB- denotes (
T9072 1856-1859 NNP denotes NAD
T9071 1852-1855 CC denotes and
T9070 1850-1851 -RRB- denotes )
T9069 1846-1850 JJ denotes HO-1
T9068 1845-1846 -LRB- denotes (
T9067 1833-1844 JJ denotes oxygenase-1
T9066 1828-1832 NN denotes heme
T9065 1825-1827 IN denotes as
T9064 1820-1824 JJ denotes such
T9063 1818-1819 , denotes ,
T9062 1813-1818 NNS denotes genes
T9061 1801-1812 JJ denotes antioxidant
T9060 1798-1800 IN denotes of
T9059 1792-1797 NN denotes group
T9058 1790-1791 DT denotes a
T9057 1787-1789 IN denotes of
T9056 1773-1786 NN denotes transcription
T9055 1763-1772 NNS denotes activates
T9054 1758-1762 JJ denotes Nrf2
T9053 1755-1757 IN denotes of
T9052 1749-1754 NN denotes level
T9051 1740-1748 JJ denotes Enhanced
T9050 1738-1739 . denotes .
T9049 1737-1738 NNP denotes ]
T9048 1735-1737 CD denotes 17
T9047 1734-1735 NNP denotes [
T9046 1730-1733 NNP denotes TBI
T9045 1724-1729 IN denotes after
T9044 1717-1723 NN denotes tissue
T9043 1711-1716 NN denotes brain
T9042 1708-1710 IN denotes in
T9041 1703-1707 NNP denotes Nrf2
T9040 1700-1702 IN denotes of
T9039 1687-1699 NN denotes augmentation
T9038 1683-1686 DT denotes the
T9037 1676-1682 VBN denotes proved
T9036 1672-1675 VBZ denotes has
T9035 1666-1671 NN denotes study
T9034 1657-1665 JJ denotes previous
T9033 1653-1656 PRP$ denotes Our
T9032 1651-1652 . denotes .
T9031 1648-1651 NNP denotes TBI
T9030 1645-1647 IN denotes in
T9029 1636-1644 VBN denotes involved
T9028 1632-1635 DT denotes all
T9027 1628-1631 VBP denotes are
T9026 1622-1627 WDT denotes which
T9025 1620-1621 , denotes ,
T9024 1609-1620 NNS denotes metabolites
T9023 1603-1608 JJ denotes toxic
T9022 1600-1602 IN denotes of
T9021 1587-1599 NN denotes accumulation
T9020 1583-1586 CC denotes and
T9019 1581-1582 , denotes ,
T9018 1575-1581 NN denotes damage
T9017 1562-1574 JJ denotes inflammatory
T9016 1560-1561 , denotes ,
T9015 1554-1560 NN denotes stress
T9014 1544-1553 JJ denotes oxidative
T9013 1535-1543 VBG denotes reducing
T9012 1532-1534 IN denotes in
T9011 1522-1531 NN denotes regulator
T9010 1518-1521 JJ denotes key
T9009 1514-1517 DT denotes the
T9008 1511-1513 VB denotes be
T9007 1508-1510 TO denotes to
T9006 1501-1507 VBN denotes proved
T9005 1496-1500 VBN denotes been
T9004 1492-1495 VBZ denotes has
T9003 1484-1491 NN denotes pathway
T9002 1475-1483 JJ denotes Nrf2-ARE
T9001 1473-1474 . denotes .
T9000 1470-1473 NNP denotes TBI
T8999 1464-1469 IN denotes after
T8998 1459-1463 NN denotes loop
T8997 1444-1458 JJ denotes autoregulatory
T8996 1439-1443 JJ denotes such
T8995 1431-1438 VB denotes prevent
T8994 1428-1430 TO denotes to
T8993 1421-1427 NN denotes factor
T8992 1412-1420 JJ denotes upstream
T8991 1409-1411 DT denotes an
T8990 1406-1408 IN denotes on
T8989 1396-1405 VBG denotes targeting
T8988 1392-1395 IN denotes for
T8987 1385-1391 NN denotes choice
T8986 1380-1384 JJ denotes good
T8985 1378-1379 DT denotes a
T8984 1375-1377 VBZ denotes is
T8983 1372-1374 PRP denotes It
T8982 1370-1371 . denotes .
T8981 1365-1370 NN denotes brain
T8980 1362-1364 TO denotes to
T8979 1355-1361 NN denotes injury
T8978 1345-1354 JJ denotes secondary
T8977 1337-1344 VBZ denotes induces
T8976 1333-1336 CC denotes and
T8975 1320-1332 NN denotes inflammation
T8974 1317-1319 IN denotes of
T8973 1310-1316 NN denotes effect
T8972 1301-1309 JJ denotes damaging
T8971 1297-1300 DT denotes the
T8970 1286-1296 VBZ denotes aggravates
T8969 1276-1285 RB denotes extremely
T8968 1271-1275 NN denotes loop
T8967 1256-1270 JJ denotes autoregulatory
T8966 1251-1255 DT denotes This
T8965 1249-1250 . denotes .
T8964 1248-1249 NN denotes ]
T8963 1246-1248 CD denotes 16
T8962 1244-1245 , denotes ,
T8961 1242-1244 CD denotes 15
T8960 1241-1242 NNP denotes [
T8959 1235-1240 NNP denotes NF-κB
T8958 1232-1234 IN denotes of
T8957 1221-1231 NN denotes activation
T8956 1214-1220 VB denotes induce
T8955 1210-1213 MD denotes can
T8954 1205-1209 RB denotes also
T8953 1199-1204 NNP denotes IL-1β
T8952 1195-1198 CC denotes and
T8951 1189-1194 NNP denotes TNF-α
T8950 1185-1188 CC denotes and
T8949 1183-1184 , denotes ,
T8948 1182-1183 NNP denotes ]
T8947 1180-1182 CD denotes 14
T8946 1179-1180 NNP denotes [
T8945 1173-1178 NNS denotes cells
T8944 1163-1172 NN denotes carcinoma
T8943 1157-1162 NN denotes colon
T8942 1151-1156 JJ denotes human
T8941 1148-1150 IN denotes in
T8940 1143-1147 NNP denotes MMP9
T8939 1140-1142 IN denotes of
T8938 1125-1139 NN denotes overexpression
T8937 1117-1124 VBZ denotes induces
T8936 1112-1116 NNP denotes IL-6
T8935 1108-1111 CC denotes and
T8934 1106-1107 , denotes ,
T8933 1105-1106 NNP denotes ]
T8932 1103-1105 CD denotes 13
T8931 1101-1102 , denotes ,
T8930 1099-1101 CD denotes 12
T8929 1098-1099 NNP denotes [
T8928 1087-1097 NNS denotes astrocytes
T8927 1084-1086 IN denotes in
T8926 1079-1083 NNP denotes MMP9
T8925 1075-1078 IN denotes for
T9629 5044-5054 NN denotes conclusion
T9628 5041-5043 IN denotes In
T9627 5039-5040 . denotes .
T9626 5035-5039 NN denotes time
T9625 5029-5034 JJ denotes first
T9624 5025-5028 DT denotes the
T9623 5021-5024 IN denotes for
T9622 5014-5020 NN denotes injury
T9621 5006-5013 NN denotes scratch
T9620 5000-5005 IN denotes after
T9619 4989-4999 NNS denotes astrocytes
T9618 4980-4988 NN denotes knockout
T9617 4975-4979 NNP denotes Nrf2
T9616 4972-4974 IN denotes in
T9615 4967-4971 NNP denotes MMP9
T9614 4963-4966 CC denotes and
T9613 4961-4962 , denotes ,
T9612 4957-4961 NNP denotes IL-6
T9611 4955-4956 , denotes ,
T9610 4950-4955 NNP denotes IL-1β
T9609 4948-4949 , denotes ,
T9608 4943-4948 NNP denotes TNF-α
T9607 4940-4942 IN denotes of
T9606 4929-4939 NN denotes expression
T9605 4917-4928 JJ denotes upregulated
T9604 4913-4916 DT denotes the
T9603 4900-4912 VBD denotes demonstrated
T9602 4892-4899 NNS denotes results
T9601 4888-4891 PRP$ denotes Our
T9600 4886-4887 . denotes .
T9599 4883-4886 NNP denotes TBI
T9598 4877-4882 IN denotes after
T9597 4867-4876 NNS denotes mediators
T9596 4851-4866 JJ denotes proinflammatory
T9595 4847-4850 CC denotes and
T9594 4845-4846 , denotes ,
T9593 4841-4845 NNP denotes Nrf2
T9592 4839-4840 , denotes ,
T9591 4829-4839 NNS denotes astrocytes
T9590 4823-4828 IN denotes among
T9589 4810-4822 NN denotes relationship
T9588 4806-4809 DT denotes the
T9587 4803-4805 IN denotes on
T9586 4795-4802 VBD denotes focused
T9585 4789-4794 NN denotes study
T9584 4786-4788 DT denotes no
T9583 4783-4785 VBZ denotes is
T9582 4777-4782 EX denotes there
T9581 4775-4776 , denotes ,
T9580 4772-4775 RB denotes now
T9579 4767-4771 IN denotes till
T9578 4763-4766 CC denotes But
T9577 4761-4762 . denotes .
T9576 4755-4761 NN denotes injury
T9575 4749-4754 NN denotes brain
T9574 4743-4748 IN denotes after
T9573 4735-4742 NN denotes process
T9572 4722-4734 JJ denotes inflammatory
T9571 4719-4721 IN denotes in
T9570 4708-4718 NNS denotes astrocytes
T9569 4705-4707 IN denotes of
T9568 4700-4704 NN denotes role
T9567 4696-4699 DT denotes the
T9566 4687-4695 VBP denotes indicate
T9565 4679-4686 NNS denotes results
T9564 4673-4678 DT denotes Those
T9563 4671-4672 . denotes .
T9562 4670-4671 NNP denotes ]
T9561 4668-4670 CD denotes 29
T9560 4667-4668 NNP denotes [
T9559 4646-4666 NN denotes immunohistochemistry
T9558 4643-4645 IN denotes by
T9557 4635-4642 NNS denotes tissues
T9556 4629-4634 NN denotes brain
T9555 4626-4628 IN denotes in
T9554 4617-4625 VBN denotes observed
T9553 4612-4616 VBD denotes were
T9552 4601-4611 NNS denotes astrocytes
T9551 4587-4600 JJ denotes MMP9-positive
T9550 4585-4586 , denotes ,
T9549 4576-4585 NN denotes occlusion
T9548 4569-4575 NN denotes artery
T9547 4560-4568 JJ denotes cerebral
T9546 4553-4559 JJ denotes middle
T9545 4547-4552 IN denotes after
T9544 4542-4546 IN denotes that
T9543 4533-4541 VBD denotes revealed
T9542 4527-4532 NN denotes study
T9541 4519-4526 DT denotes Another
T9540 4517-4518 . denotes .
T9539 4516-4517 NN denotes ]
T9538 4514-4516 CD denotes 28
T9537 4512-4513 , denotes ,
T9536 4510-4512 CD denotes 27
T9535 4509-4510 NNP denotes [
T9534 4495-4508 VBN denotes oxyhemoglobin
T9533 4492-4494 CC denotes or
T9532 4488-4491 NNP denotes LPS
T9531 4483-4487 IN denotes with
T9530 4473-4482 NN denotes treatment
T9529 4467-4472 IN denotes after
T9528 4456-4466 NNS denotes astrocytes
T9527 4447-4455 JJ denotes cultured
T9526 4444-4446 IN denotes in
T9525 4439-4443 NNP denotes IL-6
T9524 4435-4438 CC denotes and
T9523 4433-4434 , denotes ,
T9522 4428-4433 NNP denotes IL-1β
T9521 4426-4427 , denotes ,
T9520 4421-4426 NNP denotes TNF-α
T9519 4418-4420 IN denotes of
T9518 4407-4417 NN denotes expression
T9517 4403-4406 DT denotes the
T9516 4392-4402 VBD denotes identified
T9515 4386-4391 NN denotes study
T9514 4377-4385 JJ denotes Previous
T9513 4375-4376 . denotes .
T9512 4372-4375 NNP denotes TBI
T9511 4366-4371 IN denotes after
T9510 4358-4365 NN denotes pathway
T9509 4349-4357 JJ denotes Nrf2-ARE
T9508 4346-4348 IN denotes of
T9507 4335-4345 NN denotes activation
T9506 4332-4334 IN denotes in
T9505 4326-4331 NNS denotes cells
T9504 4315-4325 NN denotes respondent
T9503 4312-4314 IN denotes of
T9502 4307-4311 NN denotes kind
T9501 4303-4306 CD denotes one
T9500 4300-4302 VB denotes be
T9499 4296-4299 MD denotes may
T9498 4285-4295 NNS denotes astrocytes
T9497 4280-4284 IN denotes that
T9496 4271-4279 VBN denotes reasoned
T9495 4268-4270 VB denotes be
T9494 4264-4267 MD denotes can
T9493 4261-4263 PRP denotes it
T9492 4259-4260 , denotes ,
T9491 4252-4259 NN denotes nucleus
T9490 4249-4251 IN denotes in
T9489 4242-4248 RB denotes mainly
T9488 4233-4241 NN denotes function
T9487 4228-4232 VB denotes take
T9486 4221-4227 MD denotes should
T9485 4215-4220 WDT denotes which
T9484 4208-4214 NN denotes factor
T9483 4194-4207 NN denotes transcription
T9482 4192-4193 DT denotes a
T9481 4189-4191 VBZ denotes is
T9480 4184-4188 NNP denotes Nrf2
T9479 4179-4183 IN denotes that
T9478 4174-4178 NN denotes fact
T9477 4170-4173 DT denotes the
T9476 4167-4169 IN denotes of
T9475 4162-4166 NN denotes view
T9474 4159-4161 IN denotes In
T9473 4157-4158 . denotes .
T9472 4156-4157 NNP denotes ]
T9471 4154-4156 CD denotes 18
T9470 4153-4154 NNP denotes [
T9469 4149-4152 NNP denotes TBI
T9468 4143-4148 IN denotes after
T9467 4132-4142 NNS denotes astrocytes
T9466 4129-4131 IN denotes of
T9465 4121-4128 NN denotes nucleus
T9464 4118-4120 IN denotes in
T9463 4109-4117 VBN denotes detected
T9462 4102-4108 RB denotes mainly
T9461 4099-4101 VBZ denotes is
T9460 4094-4098 NNP denotes Nrf2
T9459 4089-4093 IN denotes that
T9458 4079-4088 VBN denotes confirmed
T9457 4074-4078 VBN denotes been
T9456 4070-4073 VBZ denotes has
T9455 4067-4069 PRP denotes It
T9454 4065-4066 . denotes .
T9453 4064-4065 NNP denotes ]
T9452 4062-4064 CD denotes 26
T9451 4061-4062 NNP denotes [
T9450 4053-4060 VBP denotes pathway
T9449 4051-4052 -RRB- denotes )
T9448 4046-4051 NNS denotes MAPKs
T9447 4045-4046 -LRB- denotes (
T9446 4038-4044 NN denotes kinase
T9445 4030-4037 NN denotes protein
T9444 4012-4029 JJ denotes mitogen-activated
T9443 4003-4011 JJ denotes upstream
T9442 3999-4002 DT denotes the
T9441 3996-3998 IN denotes by
T9440 3986-3995 VBN denotes regulated
T8924 1063-1074 NNS denotes stimulators
T8923 1056-1062 JJ denotes potent
T8922 1052-1055 VBP denotes are
T8921 1046-1051 NNP denotes IL-1β
T8920 1042-1045 CC denotes and
T8919 1036-1041 NNP denotes TNF-α
T8918 1034-1035 , denotes ,
T8917 1027-1034 NN denotes example
T8916 1023-1026 IN denotes For
T8915 1021-1022 . denotes .
T8914 1012-1021 NNS denotes mediators
T8913 996-1011 JJ denotes proinflammatory
T8912 990-995 DT denotes these
T8911 984-989 IN denotes among
T8910 979-983 NN denotes loop
T8909 964-978 JJ denotes autoregulatory
T8908 961-963 DT denotes an
T8907 958-960 VBZ denotes is
T8906 952-957 EX denotes there
T8905 947-951 IN denotes that
T8904 934-946 VBN denotes demonstrated
T8903 929-933 VBN denotes been
T8902 925-928 VBZ denotes has
T8901 922-924 PRP denotes It
T8900 920-921 . denotes .
T8899 910-920 NNS denotes astrocytes
T8832 538-543 JJ denotes NF-κB
T8831 536-537 , denotes ,
T8830 530-536 NN denotes factor
T8829 519-529 NN denotes transcript
T8828 517-518 DT denotes a
T8827 514-516 IN denotes As
T8826 512-513 . denotes .
T8825 511-512 NN denotes ]
T8824 510-511 CD denotes 9
T8823 508-509 , denotes ,
T8822 507-508 CD denotes 2
T8821 506-507 NN denotes [
T8820 499-505 NN denotes injury
T8819 489-498 JJ denotes traumatic
T8818 483-488 IN denotes after
T8817 478-482 NN denotes cord
T8816 471-477 JJ denotes spinal
T8815 467-470 CC denotes and
T8814 461-466 NN denotes brain
T8813 458-460 IN denotes in
T8812 448-457 VBN denotes activated
T8811 445-447 VBZ denotes is
T8810 439-444 NNP denotes NF-κB
T8809 434-438 IN denotes that
T8808 421-433 VBN denotes demonstrated
T8807 416-420 VBN denotes been
T8806 412-415 VBZ denotes has
T8805 409-411 PRP denotes It
T8804 407-408 . denotes .
T8803 403-407 NN denotes time
T8802 397-402 JJ denotes first
T8801 393-396 DT denotes the
T8800 389-392 IN denotes for
T8799 378-388 NNS denotes astrocytes
T8798 369-377 NN denotes wildtype
T8797 366-368 IN denotes in
T8796 360-365 DT denotes those
T8795 355-359 IN denotes than
T8794 344-354 NNS denotes astrocytes
T8793 335-343 VBD denotes cultured
T8792 326-334 NN denotes knockout
T8791 321-325 JJ denotes Nrf2
T8790 318-320 IN denotes in
T8789 308-317 NNS denotes cytokines
T8788 292-307 JJ denotes proinflammatory
T8787 289-291 IN denotes of
T8786 278-288 NN denotes expression
T8785 269-277 JJ denotes enhanced
T8784 265-268 CC denotes and
T8783 259-264 NNP denotes NF-κB
T8782 256-258 IN denotes of
T8781 247-255 NN denotes activity
T8780 240-246 JJR denotes higher
T8779 232-239 VBD denotes induced
T8778 225-231 NN denotes injury
T8777 217-224 NN denotes scratch
T8776 212-216 IN denotes that
T8775 203-211 VBD denotes revealed
T8774 200-202 PRP denotes we
T8773 195-199 RB denotes Also
T8772 193-194 . denotes .
T8771 183-193 NNS denotes astrocytes
T8770 174-182 JJ denotes cultured
T8769 171-173 IN denotes in
T8768 166-170 NNP denotes MMP9
T8767 162-165 CC denotes and
T8766 160-161 , denotes ,
T8765 156-160 NNP denotes IL-6
T8764 154-155 , denotes ,
T8763 149-154 NNP denotes IL-1β
T8762 147-148 , denotes ,
T8761 142-147 NNP denotes TNF-α
T8760 139-141 IN denotes of
T8759 124-138 NN denotes overexpression
T8758 120-123 CC denotes and
T8757 111-119 NN denotes activity
T8756 103-110 JJ denotes binding
T8755 99-102 NNP denotes DNA
T8754 93-98 NNP denotes NF-κB
T8753 90-92 IN denotes of
T8752 77-89 NN denotes upregulation
T8751 73-76 DT denotes the
T8750 65-72 VBD denotes induced
T8749 58-64 NN denotes injury
T8748 50-57 NN denotes scratch
T8747 45-49 IN denotes that
T8746 32-44 VBD denotes demonstrated
T8745 26-31 NN denotes study
T8744 18-25 JJ denotes present
T8743 14-17 DT denotes The
T9633 5069-5073 JJ denotes Nrf2
T9632 5066-5068 IN denotes of
T9631 5056-5065 NN denotes depletion
T9630 5054-5055 , denotes ,
T9223 2693-2697 IN denotes from
T9222 2684-2692 VBD denotes obtained
T9221 2679-2683 NNP denotes Data
T9220 2677-2678 . denotes .
T9219 2671-2677 NNS denotes deaths
T9218 2660-2670 NNS denotes astrocytes
T9217 2655-2659 JJR denotes more
T9216 2652-2654 TO denotes to
T9215 2648-2651 VBD denotes led
T9214 2638-2647 NNS denotes mediators
T9213 2622-2637 JJ denotes proinflammatory
T9212 2616-2621 DT denotes these
T9211 2613-2615 IN denotes of
T9210 2598-2612 NN denotes overexpression
T9209 2594-2597 CC denotes and
T9208 2592-2593 , denotes ,
T9207 2588-2592 NN denotes time
T9206 2582-2587 JJ denotes first
T9205 2578-2581 DT denotes the
T9204 2574-2577 IN denotes for
T9203 2562-2573 NNS denotes astrocyetes
T9202 2553-2561 NN denotes wildtype
T9201 2550-2552 IN denotes in
T9200 2545-2549 IN denotes than
T9199 2534-2544 NNS denotes astrocytes
T9198 2525-2533 NN denotes knockout
T9197 2520-2524 JJ denotes Nrf2
T9196 2511-2519 JJ denotes cultured
T9195 2508-2510 IN denotes in
T9194 2497-2507 VBN denotes aggravated
T9193 2492-2496 RBR denotes more
T9192 2488-2491 VBD denotes was
T9191 2481-2487 NN denotes injury
T9190 2473-2480 NN denotes scratch
T9189 2467-2472 IN denotes after
T9188 2462-2466 NNP denotes MMP9
T9187 2458-2461 CC denotes and
T9186 2456-2457 , denotes ,
T9185 2452-2456 NNP denotes IL-6
T9184 2450-2451 , denotes ,
T9183 2445-2450 NNP denotes IL-1β
T9182 2443-2444 , denotes ,
T9181 2438-2443 NNP denotes TNF-α
T9180 2435-2437 IN denotes of
T9179 2420-2434 NN denotes overexpression
T9178 2415-2419 IN denotes that
T9177 2406-2414 VBD denotes revealed
T9176 2398-2405 NNS denotes results
T9175 2394-2397 PRP$ denotes our
T9174 2392-2393 , denotes ,
T9173 2388-2392 RB denotes Here
T9172 2386-2387 . denotes .
T9171 2385-2386 NNP denotes ]
T9170 2383-2385 CD denotes 20
T9169 2382-2383 NNP denotes [
T9168 2378-2381 NNP denotes TBI
T9167 2372-2377 IN denotes after
T9166 2366-2371 NN denotes brain
T9165 2363-2365 IN denotes in
T9164 2353-2362 NNS denotes mediators
T9163 2337-2352 JJ denotes proinflammatory
T9162 2334-2336 IN denotes of
T9161 2323-2333 NN denotes expression
T9160 2316-2322 JJR denotes higher
T9159 2308-2315 VBZ denotes induces
T9158 2303-2307 JJ denotes Nrf2
T9157 2300-2302 IN denotes of
T9156 2290-2299 NN denotes Depletion
T9155 2288-2289 . denotes .
T9154 2285-2288 NNP denotes TBI
T9153 2282-2284 TO denotes to
T9152 2270-2281 JJ denotes susceptible
T9151 2265-2269 JJR denotes more
T9150 2258-2264 VBP denotes appear
T9149 2253-2257 NNS denotes mice
T9148 2238-2252 JJ denotes Nrf2-deficient
T9147 2236-2237 , denotes ,
T9146 2232-2236 NN denotes hand
T9145 2226-2231 JJ denotes other
T9144 2222-2225 DT denotes the
T9143 2219-2221 IN denotes On
T9142 2217-2218 . denotes .
T9141 2216-2217 NNP denotes ]
T9140 2214-2216 CD denotes 19
T9139 2213-2214 NNP denotes [
T9138 2209-2212 NNP denotes TBI
T9137 2203-2208 IN denotes after
T9136 2191-2202 NN denotes hippocampus
T9135 2188-2190 IN denotes of
T9134 2179-2187 NN denotes subfield
T9133 2175-2178 NNP denotes CA3
T9132 2171-2174 DT denotes the
T9131 2167-2170 CC denotes and
T9130 2160-2166 NN denotes cortex
T9129 2156-2159 DT denotes the
T9128 2153-2155 IN denotes in
T9127 2151-2152 , denotes ,
T9126 2139-2151 NN denotes peroxidation
T9125 2133-2138 JJ denotes lipid
T9124 2130-2132 IN denotes of
T9123 2123-2129 NN denotes marker
T9122 2121-2122 DT denotes a
T9121 2119-2120 , denotes ,
T9120 2118-2119 -RRB- denotes )
T9119 2113-2118 JJ denotes 4-HNE
T9118 2112-2113 -LRB- denotes (
T9117 2095-2111 JJ denotes 4-Hydroxynonenal
T9116 2091-2094 IN denotes for
T9115 2074-2090 NN denotes immunoreactivity
T8898 901-909 JJ denotes cultured
T8897 898-900 IN denotes in
T8896 892-897 IN denotes above
T8895 882-891 VBN denotes mentioned
T8894 872-881 NNS denotes mediators
T8893 856-871 JJ denotes proinflammatory
T8892 852-855 CC denotes and
T8891 850-851 , denotes ,
T8890 846-850 NNP denotes MMP9
T8889 843-845 IN denotes of
T8888 828-842 NN denotes overexpression
T8887 826-827 , denotes ,
T8886 818-826 NN denotes activity
T8885 810-817 JJ denotes binding
T8884 806-809 NNP denotes DNA
T8883 800-805 NNP denotes NF-κB
T8882 797-799 IN denotes of
T8881 787-796 NN denotes elevation
T8880 779-786 VBD denotes induced
T8879 772-778 NN denotes injury
T8878 764-771 NN denotes scratch
T8877 759-763 IN denotes that
T8876 750-758 VBD denotes revealed
T8875 745-749 RB denotes also
T8874 737-744 NNS denotes results
T8873 733-736 PRP$ denotes Our
T8872 731-732 . denotes .
T8871 730-731 NN denotes ]
T8870 728-730 CD denotes 11
T8869 726-727 , denotes ,
T8868 724-726 CD denotes 10
T8867 722-723 , denotes ,
T8866 721-722 CD denotes 3
T8865 720-721 NNP denotes [
T8864 716-719 NNP denotes TBI
T8863 710-715 IN denotes after
T8853 669-674 NNP denotes TNF-α
T8852 659-668 VBG denotes including
T8851 657-658 , denotes ,
T8850 648-657 NNS denotes cytokines
T8849 632-647 JJ denotes proinflammatory
T8848 629-631 IN denotes of
T8847 621-628 NN denotes battery
T8846 619-620 DT denotes a
T8845 615-618 CC denotes and
T8844 610-614 NNP denotes MMP9
T8843 607-609 IN denotes of
T8842 593-606 NN denotes transcription
T8841 585-592 VBZ denotes induces
T8840 581-584 CC denotes and
T8839 571-580 VBN denotes activated
T8838 567-570 VBD denotes was
T8837 564-566 PRP denotes it
T8836 559-563 IN denotes once
T8835 555-558 NNP denotes DNA
T8834 550-554 IN denotes with
T8833 544-549 NNS denotes binds
T8862 702-709 NNS denotes tissues
T8861 696-701 NN denotes brain
T8860 693-695 IN denotes in
T8859 691-692 , denotes ,
T8858 687-691 NNP denotes IL-6
T8857 683-686 CC denotes and
T8856 681-682 , denotes ,
T8855 676-681 NNP denotes IL-1β
T8854 674-675 , denotes ,
T9411 3821-3824 DT denotes the
R7091 T8763 T8761 conj IL-1β,TNF-α
R7092 T8764 T8763 punct ",",IL-1β
R7093 T8765 T8763 conj IL-6,IL-1β
R7094 T8766 T8765 punct ",",IL-6
R7095 T8767 T8765 cc and,IL-6
R7096 T8768 T8765 conj MMP9,IL-6
R7097 T8769 T8752 prep in,upregulation
R7098 T8770 T8771 amod cultured,astrocytes
R7099 T8771 T8769 pobj astrocytes,in
R7100 T8772 T8746 punct .,demonstrated
R7101 T8773 T8775 advmod Also,revealed
R7102 T8774 T8775 nsubj we,revealed
R7103 T8775 T8775 ROOT revealed,revealed
R7104 T8776 T8779 mark that,induced
R7105 T8777 T8778 compound scratch,injury
R7106 T8778 T8779 nsubj injury,induced
R7107 T8779 T8775 ccomp induced,revealed
R7108 T8780 T8781 amod higher,activity
R7109 T8781 T8779 dobj activity,induced
R7110 T8782 T8781 prep of,activity
R7111 T8783 T8782 pobj NF-κB,of
R7112 T8784 T8781 cc and,activity
R7113 T8785 T8786 amod enhanced,expression
R7114 T8786 T8781 conj expression,activity
R7115 T8787 T8786 prep of,expression
R7116 T8788 T8789 amod proinflammatory,cytokines
R7117 T8789 T8787 pobj cytokines,of
R7118 T8790 T8789 prep in,cytokines
R7119 T8791 T8792 amod Nrf2,knockout
R7120 T8792 T8790 pobj knockout,in
R7121 T8793 T8779 conj cultured,induced
R7122 T8794 T8793 dobj astrocytes,cultured
R7123 T8795 T8794 prep than,astrocytes
R7124 T8796 T8795 pobj those,than
R7125 T8797 T8796 prep in,those
R7126 T8798 T8799 compound wildtype,astrocytes
R7127 T8799 T8797 pobj astrocytes,in
R7128 T8800 T8793 prep for,cultured
R7129 T8801 T8803 det the,time
R7130 T8802 T8803 amod first,time
R7131 T8803 T8800 pobj time,for
R7132 T8804 T8775 punct .,revealed
R7133 T8805 T8808 nsubjpass It,demonstrated
R7134 T8806 T8808 aux has,demonstrated
R7135 T8807 T8808 auxpass been,demonstrated
R7136 T8808 T8808 ROOT demonstrated,demonstrated
R7137 T8809 T8812 mark that,activated
R7138 T8810 T8812 nsubjpass NF-κB,activated
R7139 T8811 T8812 auxpass is,activated
R7140 T8812 T8808 ccomp activated,demonstrated
R7141 T8813 T8812 prep in,activated
R7142 T8814 T8813 pobj brain,in
R7143 T8815 T8814 cc and,brain
R7144 T8816 T8817 amod spinal,cord
R7145 T8817 T8814 conj cord,brain
R7146 T8818 T8812 prep after,activated
R7147 T8819 T8821 amod traumatic,[
R7148 T8820 T8821 compound injury,[
R7149 T8821 T8818 pobj [,after
R7150 T8822 T8821 nummod 2,[
R7167 T8839 T8839 ROOT activated,activated
R7168 T8840 T8839 cc and,activated
R7169 T8841 T8839 conj induces,activated
R7170 T8842 T8841 dobj transcription,induces
R7171 T8843 T8842 prep of,transcription
R7172 T8844 T8843 pobj MMP9,of
R7173 T8845 T8842 cc and,transcription
R7174 T8846 T8847 det a,battery
R7175 T8847 T8842 conj battery,transcription
R7176 T8848 T8847 prep of,battery
R7177 T8849 T8850 amod proinflammatory,cytokines
R7178 T8850 T8848 pobj cytokines,of
R7179 T8851 T8850 punct ",",cytokines
R7180 T8852 T8850 prep including,cytokines
R7181 T8853 T8852 pobj TNF-α,including
R7182 T8854 T8853 punct ",",TNF-α
R7183 T8855 T8853 conj IL-1β,TNF-α
R7184 T8856 T8855 punct ",",IL-1β
R7185 T8857 T8855 cc and,IL-1β
R7186 T8858 T8855 conj IL-6,IL-1β
R7187 T8859 T8850 punct ",",cytokines
R7188 T8860 T8847 prep in,battery
R7189 T8861 T8862 compound brain,tissues
R7190 T8862 T8860 pobj tissues,in
R7191 T8863 T8841 prep after,induces
R7192 T8864 T8865 compound TBI,[
R7193 T8865 T8863 pobj [,after
R7194 T8866 T8868 quantmod 3,10
R7195 T8867 T8868 punct ",",10
R7196 T8868 T8871 nummod 10,]
R7197 T8869 T8870 punct ",",11
R7198 T8870 T8871 nummod 11,]
R7199 T8871 T8865 appos ],[
R7200 T8872 T8839 punct .,activated
R7201 T8873 T8874 poss Our,results
R7202 T8874 T8876 nsubj results,revealed
R7203 T8875 T8876 advmod also,revealed
R7204 T8876 T8876 ROOT revealed,revealed
R7205 T8877 T8880 mark that,induced
R7206 T8878 T8879 compound scratch,injury
R7207 T8879 T8880 nsubj injury,induced
R7208 T8880 T8876 ccomp induced,revealed
R7209 T8881 T8880 dobj elevation,induced
R7210 T8882 T8881 prep of,elevation
R7211 T8883 T8884 compound NF-κB,DNA
R7212 T8884 T8882 pobj DNA,of
R7213 T8885 T8886 amod binding,activity
R7214 T8886 T8880 conj activity,induced
R7215 T8887 T8886 punct ",",activity
R7216 T8888 T8886 conj overexpression,activity
R7217 T8889 T8888 prep of,overexpression
R7218 T8890 T8889 pobj MMP9,of
R7219 T8891 T8888 punct ",",overexpression
R7220 T8892 T8888 cc and,overexpression
R7221 T8893 T8894 amod proinflammatory,mediators
R7222 T8894 T8888 conj mediators,overexpression
R7223 T8895 T8894 acl mentioned,mediators
R7224 T8896 T8895 advmod above,mentioned
R7225 T8897 T8895 prep in,mentioned
R7226 T8898 T8899 amod cultured,astrocytes
R7227 T8899 T8897 pobj astrocytes,in
R7228 T8900 T8876 punct .,revealed
R7248 T8920 T8919 cc and,TNF-α
R7249 T8921 T8919 conj IL-1β,TNF-α
R7250 T8922 T8922 ROOT are,are
R7251 T8923 T8924 amod potent,stimulators
R7252 T8924 T8922 attr stimulators,are
R7253 T8925 T8924 prep for,stimulators
R7254 T8926 T8925 pobj MMP9,for
R7255 T8927 T8924 prep in,stimulators
R7256 T8928 T8927 pobj astrocytes,in
R7257 T8929 T8933 nmod [,]
R7258 T8930 T8933 nummod 12,]
R7259 T8931 T8933 punct ",",]
R7260 T8932 T8933 nummod 13,]
R7261 T8933 T8937 nsubj ],induces
R7262 T8934 T8933 punct ",",]
R7263 T8935 T8933 cc and,]
R7264 T8936 T8933 conj IL-6,]
R7265 T8937 T8937 ROOT induces,induces
R7266 T8938 T8937 dobj overexpression,induces
R7267 T8939 T8938 prep of,overexpression
R7268 T8940 T8939 pobj MMP9,of
R7269 T8941 T8938 prep in,overexpression
R7270 T8942 T8944 amod human,carcinoma
R7271 T8943 T8944 compound colon,carcinoma
R7272 T8944 T8945 compound carcinoma,cells
R7273 T8945 T8941 pobj cells,in
R7274 T8946 T8948 nmod [,]
R7275 T8947 T8948 nummod 14,]
R7276 T8948 T8937 dobj ],induces
R7277 T8949 T8948 punct ",",]
R7278 T8950 T8948 cc and,]
R7279 T8951 T8948 conj TNF-α,]
R7280 T8952 T8951 cc and,TNF-α
R7281 T8953 T8951 conj IL-1β,TNF-α
R7282 T8954 T8956 advmod also,induce
R7283 T8955 T8956 aux can,induce
R7284 T8956 T8937 conj induce,induces
R7285 T8957 T8956 dobj activation,induce
R7286 T8958 T8957 prep of,activation
R7287 T8959 T8960 compound NF-κB,[
R7288 T8960 T8958 pobj [,of
R7289 T8961 T8960 nummod 15,[
R7290 T8962 T8960 punct ",",[
R7291 T8963 T8964 nummod 16,]
R7292 T8964 T8960 appos ],[
R7293 T8965 T8937 punct .,induces
R7294 T8966 T8968 det This,loop
R7295 T8967 T8968 amod autoregulatory,loop
R7296 T8968 T8970 nsubj loop,aggravates
R7297 T8969 T8970 advmod extremely,aggravates
R7298 T8970 T8970 ROOT aggravates,aggravates
R7299 T8971 T8973 det the,effect
R7300 T8972 T8973 amod damaging,effect
R7301 T8973 T8970 dobj effect,aggravates
R7302 T8974 T8973 prep of,effect
R7303 T8975 T8974 pobj inflammation,of
R7304 T8976 T8970 cc and,aggravates
R7305 T8977 T8970 conj induces,aggravates
R7306 T8978 T8979 amod secondary,injury
R7307 T8979 T8977 dobj injury,induces
R7327 T8998 T8995 dobj loop,prevent
R7328 T9026 T9029 nsubjpass which,involved
R7329 T9027 T9029 auxpass are,involved
R7330 T8999 T8998 prep after,loop
R7331 T9028 T9029 dep all,involved
R7332 T9029 T9024 relcl involved,metabolites
R7333 T9000 T8999 pobj TBI,after
R7334 T9030 T9029 prep in,involved
R7335 T9031 T9030 pobj TBI,in
R7336 T9001 T8984 punct .,is
R7337 T9032 T9006 punct .,proved
R7338 T9033 T9035 poss Our,study
R7339 T9002 T9003 amod Nrf2-ARE,pathway
R7340 T9034 T9035 amod previous,study
R7341 T9035 T9037 nsubj study,proved
R7342 T9036 T9037 aux has,proved
R7343 T9003 T9006 nsubjpass pathway,proved
R7344 T9037 T9037 ROOT proved,proved
R7345 T9038 T9039 det the,augmentation
R7346 T9039 T9037 dobj augmentation,proved
R7347 T9004 T9006 aux has,proved
R7348 T9040 T9039 prep of,augmentation
R7349 T9041 T9040 pobj Nrf2,of
R7350 T9042 T9039 prep in,augmentation
R7351 T9005 T9006 auxpass been,proved
R7352 T9043 T9044 compound brain,tissue
R7353 T9044 T9042 pobj tissue,in
R7354 T9045 T9037 prep after,proved
R7355 T9006 T9006 ROOT proved,proved
R7356 T9046 T9047 compound TBI,[
R7357 T9047 T9045 pobj [,after
R7358 T9007 T9008 aux to,be
R7359 T9048 T9047 nummod 17,[
R7360 T9049 T9047 conj ],[
R7361 T9008 T9006 xcomp be,proved
R7362 T9050 T9037 punct .,proved
R7363 T9051 T9052 amod Enhanced,level
R7364 T9052 T9052 ROOT level,level
R7365 T9009 T9011 det the,regulator
R7366 T9053 T9052 prep of,level
R7367 T9010 T9011 amod key,regulator
R7368 T9054 T9055 amod Nrf2,activates
R7369 T9055 T9053 pobj activates,of
R7370 T9056 T9055 dobj transcription,activates
R7371 T9011 T9008 attr regulator,be
R7374 T9012 T9011 prep in,regulator
R7375 T9013 T9012 pcomp reducing,in
R7376 T9014 T9015 amod oxidative,stress
R7377 T9015 T9013 dobj stress,reducing
R7378 T9016 T9015 punct ",",stress
R7381 T9017 T9018 amod inflammatory,damage
R7385 T9018 T9015 conj damage,stress
R7388 T9019 T9018 punct ",",damage
R7390 T9020 T9018 cc and,damage
R7391 T9021 T9018 conj accumulation,damage
R7394 T9022 T9021 prep of,accumulation
R7398 T9023 T9024 amod toxic,metabolites
R7401 T9024 T9022 pobj metabolites,of
R7407 T9078 T9079 compound quinone,oxidoreductase-1
R7409 T9079 T9052 appos oxidoreductase-1,level
R7410 T9080 T9079 punct (,oxidoreductase-1
R7411 T9081 T9079 appos NQO1,oxidoreductase-1
R7413 T9082 T9079 punct ),oxidoreductase-1
R7414 T9083 T9052 punct ",",level
R7415 T9084 T9087 nsubj which,reduce
R7417 T9085 T9087 aux would,reduce
R7418 T9086 T9087 advmod subsequently,reduce
R7420 T9087 T9052 relcl reduce,level
R7421 T9088 T9089 det the,damage
R7422 T9089 T9087 dobj damage,reduce
R7423 T9090 T9089 prep in,damage
R7424 T9091 T9090 pobj brain,in
R7426 T9092 T9094 nmod [,]
R7427 T9093 T9094 nummod 18,]
R7428 T9094 T9089 appos ],damage
R7429 T9095 T9052 punct .,level
R7430 T9096 T9097 compound Postinjury,administration
R7432 T9097 T9107 nsubj administration,improves
R7433 T9098 T9097 prep of,administration
R7434 T9099 T9098 pobj SFN,of
R7436 T9100 T9099 punct ",",SFN
R7438 T9101 T9102 det an,inducer
R7439 T9102 T9099 appos inducer,SFN
R7441 T9103 T9102 prep of,inducer
R7442 T9104 T9103 pobj Nrf2,of
R7443 T9105 T9107 punct ",",improves
R7444 T9166 T9165 pobj brain,in
R7445 T9106 T9107 advmod significantly,improves
R7446 T9107 T9107 ROOT improves,improves
R7447 T9108 T9109 amod spatial,memory
R7448 T9167 T9159 prep after,induces
R7449 T9109 T9107 dobj memory,improves
R7450 T9110 T9109 prep of,memory
R7451 T9111 T9110 pobj rat,of
R7452 T9168 T9169 compound TBI,[
R7453 T9112 T9107 cc and,improves
R7454 T9113 T9107 conj decreases,improves
R7455 T9114 T9115 det the,immunoreactivity
R7456 T9169 T9171 nmod [,]
R7457 T9115 T9113 dobj immunoreactivity,decreases
R7458 T9116 T9115 prep for,immunoreactivity
R7459 T9117 T9116 pobj 4-Hydroxynonenal,for
R7460 T9170 T9171 nummod 20,]
R7461 T9118 T9117 punct (,4-Hydroxynonenal
R7462 T9119 T9117 appos 4-HNE,4-Hydroxynonenal
R7463 T9120 T9117 punct ),4-Hydroxynonenal
R7464 T9171 T9167 pobj ],after
R7465 T9121 T9115 punct ",",immunoreactivity
R7466 T9122 T9123 det a,marker
R7467 T9123 T9115 appos marker,immunoreactivity
R7468 T9172 T9159 punct .,induces
R7469 T9124 T9123 prep of,marker
R7470 T9125 T9126 amod lipid,peroxidation
R7471 T9126 T9124 pobj peroxidation,of
R7472 T9173 T9177 advmod Here,revealed
R7473 T9127 T9113 punct ",",decreases
R7474 T9128 T9113 prep in,decreases
R7475 T9129 T9130 det the,cortex
R7476 T9130 T9128 pobj cortex,in
R7477 T9131 T9130 cc and,cortex
R7478 T9132 T9134 det the,subfield
R7479 T9174 T9177 punct ",",revealed
R7480 T9133 T9134 compound CA3,subfield
R7481 T9134 T9130 conj subfield,cortex
R7482 T9175 T9176 poss our,results
R7483 T9176 T9177 nsubj results,revealed
R7485 T9177 T9177 ROOT revealed,revealed
R7488 T9178 T9192 mark that,was
R7491 T9179 T9192 nsubj overexpression,was
R7495 T9180 T9179 prep of,overexpression
R7498 T9181 T9180 pobj TNF-α,of
R7499 T9182 T9181 punct ",",TNF-α
R7500 T9145 T9146 amod other,hand
R7501 T9146 T9143 pobj hand,On
R7502 T9183 T9181 conj IL-1β,TNF-α
R7503 T9147 T9150 punct ",",appear
R7504 T9148 T9149 amod Nrf2-deficient,mice
R7505 T9184 T9183 punct ",",IL-1β
R7506 T9149 T9150 nsubj mice,appear
R7507 T9150 T9150 ROOT appear,appear
R7508 T9185 T9183 conj IL-6,IL-1β
R7509 T9151 T9152 advmod more,susceptible
R7510 T9152 T9150 oprd susceptible,appear
R7511 T9153 T9152 prep to,susceptible
R7512 T9186 T9185 punct ",",IL-6
R7513 T9154 T9153 pobj TBI,to
R7514 T9155 T9150 punct .,appear
R7515 T9187 T9185 cc and,IL-6
R7516 T9188 T9185 conj MMP9,IL-6
R7517 T9189 T9179 prep after,overexpression
R7518 T9190 T9191 compound scratch,injury
R7519 T9191 T9189 pobj injury,after
R7520 T9192 T9194 auxpass was,aggravated
R7521 T9253 T9253 ROOT found,found
R7522 T9193 T9194 advmod more,aggravated
R7523 T9254 T9255 aux to,be
R7524 T9255 T9253 xcomp be,found
R7525 T9256 T9255 acomp able,be
R7526 T9257 T9258 aux to,inhibit
R7527 T9258 T9256 xcomp inhibit,able
R7528 T9194 T9177 ccomp aggravated,revealed
R7529 T9259 T9261 compound IKK/I,phosphorylation
R7530 T9260 T9261 compound κB,phosphorylation
R7531 T9261 T9258 dobj phosphorylation,inhibit
R7532 T9195 T9194 prep in,aggravated
R7533 T9262 T9261 cc and,phosphorylation
R7534 T9263 T9267 nummod p65,translocation
R7535 T9196 T9199 amod cultured,astrocytes
R7536 T9264 T9267 amod NF-κB,translocation
R7537 T9265 T9267 nmod subunit,translocation
R7538 T9197 T9199 amod Nrf2,astrocytes
R7539 T9266 T9267 amod nuclear,translocation
R7540 T9267 T9261 conj translocation,phosphorylation
R7541 T9198 T9199 compound knockout,astrocytes
R7542 T9268 T9253 punct ",",found
R7543 T9269 T9270 advmod consequently,alleviating
R7544 T9270 T9253 advcl alleviating,found
R7545 T9199 T9195 pobj astrocytes,in
R7546 T9271 T9270 dobj NF-κB,alleviating
R7547 T9272 T9271 csubj signaling,NF-κB
R7548 T9273 T9275 nmod [,]
R7549 T9200 T9194 prep than,aggravated
R7550 T9274 T9275 nummod 21,]
R7551 T9275 T9272 dobj ],signaling
R7552 T9276 T9253 punct .,found
R7553 T9201 T9200 prep in,than
R7554 T9277 T9288 cc And,attenuated
R7555 T9278 T9279 amod NF-κB,activation
R7556 T9279 T9288 nsubjpass activation,attenuated
R7557 T9202 T9203 compound wildtype,astrocyetes
R7558 T9280 T9279 acl induced,activation
R7559 T9281 T9280 agent by,induced
R7560 T9282 T9281 pobj lipopolysaccharide,by
R7561 T9203 T9201 pobj astrocyetes,in
R7562 T9204 T9194 prep for,aggravated
R7563 T9205 T9207 det the,time
R7564 T9283 T9284 punct (,LPS
R7565 T9206 T9207 amod first,time
R7566 T9284 T9282 appos LPS,lipopolysaccharide
R7567 T9207 T9204 pobj time,for
R7568 T9285 T9282 punct ),lipopolysaccharide
R7569 T9286 T9288 aux could,attenuated
R7570 T9208 T9194 punct ",",aggravated
R7571 T9287 T9288 auxpass be,attenuated
R7572 T9288 T9288 ROOT attenuated,attenuated
R7573 T9289 T9288 agent by,attenuated
R7574 T9290 T9292 amod diverse,activators
R7575 T9291 T9292 amod Nrf2,activators
R7576 T9292 T9289 pobj activators,by
R7577 T9209 T9194 cc and,aggravated
R7578 T9293 T9292 punct ",",activators
R7579 T9294 T9295 amod such,as
R7580 T9295 T9292 prep as,activators
R7581 T9296 T9295 pobj SFN,as
R7582 T9210 T9215 nsubj overexpression,led
R7583 T9297 T9296 cc and,SFN
R7584 T9298 T9302 nmod curcumin,[
R7585 T9211 T9210 prep of,overexpression
R7586 T9299 T9300 punct (,CUR
R7587 T9300 T9298 appos CUR,curcumin
R7588 T9301 T9302 punct ),[
R7589 T9212 T9214 det these,mediators
R7590 T9213 T9214 amod proinflammatory,mediators
R7591 T9302 T9296 conj [,SFN
R7593 T9303 T9304 nummod 22,]
R7595 T9304 T9296 conj ],SFN
R7596 T9305 T9288 punct .,attenuated
R7597 T9306 T9311 advmod Furthermore,indicate
R7599 T9307 T9311 punct ",",indicate
R7600 T9308 T9310 poss our,studies
R7601 T9309 T9310 amod previous,studies
R7603 T9310 T9311 nsubj studies,indicate
R7605 T9311 T9311 ROOT indicate,indicate
R7606 T9312 T9316 mark that,induces
R7607 T9313 T9316 nsubj depletion,induces
R7609 T9314 T9313 prep of,depletion
R7610 T9315 T9314 pobj Nrf2,of
R7612 T9316 T9311 ccomp induces,indicate
R7613 T9317 T9316 dobj augmentation,induces
R7614 T9318 T9317 prep of,augmentation
R7616 T9319 T9320 amod NF-κB,activity
R7617 T9320 T9318 pobj activity,of
R7618 T9321 T9320 cc and,activity
R7620 T9322 T9323 amod inflammatory,response
R7621 T9323 T9320 conj response,activity
R7622 T9324 T9323 prep in,response
R7624 T9325 T9324 pobj lung,in
R7625 T9326 T9325 punct ",",lung
R7626 T9327 T9325 conj brain,lung
R7627 T9328 T9327 punct ",",brain
R7628 T9329 T9323 cc and,response
R7629 T9224 T9225 compound animal,studies
R7630 T9330 T9316 oprd intestine,induces
R7631 T9331 T9316 prep after,induces
R7632 T9332 T9333 compound TBI,[
R7633 T9225 T9223 pobj studies,from
R7634 T9333 T9331 pobj [,after
R7635 T9334 T9333 nummod 4,[
R7636 T9335 T9333 punct ",",[
R7637 T9336 T9333 appos 5,[
R7638 T9226 T9222 conj suggest,obtained
R7639 T9337 T9333 punct ",",[
R7640 T9338 T9339 nummod 23,]
R7641 T9227 T9228 det the,possibility
R7642 T9339 T9333 appos ],[
R7643 T9340 T9311 punct .,indicate
R7644 T9341 T9346 nsubj Results,confirmed
R7645 T9228 T9226 dobj possibility,suggest
R7646 T9342 T9341 prep from,Results
R7647 T9343 T9344 det this,study
R7648 T9229 T9236 mark that,achieved
R7649 T9344 T9342 pobj study,from
R7650 T9345 T9346 advmod further,confirmed
R7651 T9346 T9346 ROOT confirmed,confirmed
R7652 T9230 T9231 amod antioxidant,effect
R7653 T9347 T9348 amod such,relationship
R7654 T9348 T9349 nsubj relationship,existed
R7655 T9349 T9346 ccomp existed,confirmed
R7656 T9231 T9236 nsubjpass effect,achieved
R7657 T9232 T9231 prep of,effect
R7658 T9233 T9232 pobj Nrf2,of
R7659 T9234 T9236 aux may,achieved
R7660 T9350 T9349 prep in,existed
R7661 T9235 T9236 auxpass be,achieved
R7662 T9351 T9352 amod cultured,astrocytes
R7663 T9352 T9350 pobj astrocytes,in
R7664 T9236 T9228 acl achieved,possibility
R7665 T9353 T9349 prep after,existed
R7666 T9354 T9355 compound scratch,injury
R7667 T9237 T9236 agent by,achieved
R7668 T9355 T9353 pobj injury,after
R7669 T9356 T9346 punct .,confirmed
R7670 T9357 T9358 amod Enhanced,activation
R7671 T9238 T9237 pobj suppression,by
R7672 T9358 T9363 nsubjpass activation,discovered
R7673 T9359 T9358 prep of,activation
R7674 T9360 T9359 pobj NF-κB,of
R7675 T9361 T9363 auxpass is,discovered
R7676 T9362 T9363 advmod also,discovered
R7677 T9363 T9363 ROOT discovered,discovered
R7678 T9364 T9363 prep in,discovered
R7679 T9239 T9238 prep of,suppression
R7680 T9365 T9364 pobj lung,in
R7681 T9366 T9364 punct ",",in
R7682 T9367 T9364 conj macrophages,in
R7683 T9240 T9241 amod proinflammatory,pathways
R7684 T9368 T9367 punct ",",macrophages
R7685 T9369 T9367 cc and,macrophages
R7686 T9370 T9372 amod mouse,fibroblasts
R7687 T9241 T9239 pobj pathways,of
R7688 T9371 T9372 amod embryonic,fibroblasts
R7689 T9372 T9367 conj fibroblasts,macrophages
R7690 T9242 T9244 nsubjpass which,mediated
R7691 T9373 T9372 prep of,fibroblasts
R7692 T9374 T9375 amod Nrf2-deficient,mice
R7693 T9375 T9373 pobj mice,of
R7694 T9243 T9244 auxpass are,mediated
R7695 T9376 T9363 prep after,discovered
R7696 T9377 T9378 amod experimental,sepsis
R7697 T9244 T9241 relcl mediated,pathways
R7698 T9378 T9376 pobj sepsis,after
R7699 T9379 T9381 nmod [,]
R7700 T9245 T9244 agent by,mediated
R7701 T9380 T9381 nummod 24,]
R7702 T9246 T9247 amod NF-κB,signaling
R7703 T9247 T9245 pcomp signaling,by
R7706 T9248 T9222 punct .,obtained
R7710 T9249 T9253 nsubjpass Administration,found
R7714 T9250 T9249 prep of,Administration
R7716 T9251 T9250 pobj SFN,of
R7717 T9390 T9391 aux can,inhibit
R7718 T9391 T9387 ccomp inhibit,reported
R7719 T9392 T9391 dobj Nrf2,inhibit
R7720 T9252 T9253 auxpass is,found
R7721 T9393 T9391 prep at,inhibit
R7722 T9394 T9395 amod transcriptional,level
R7723 T9411 T9413 det the,domain
R7724 T9395 T9393 pobj level,at
R7725 T9396 T9387 punct .,reported
R7726 T9397 T9399 nmod NF-κB,subunit
R7727 T9398 T9397 nummod p65,NF-κB
R7728 T9399 T9400 nsubj subunit,repressed
R7729 T9400 T9400 ROOT repressed,repressed
R7730 T9401 T9403 det the,pathway
R7731 T9412 T9413 compound CH1-KIX,domain
R7732 T9402 T9403 amod Nrf2-ARE,pathway
R7733 T9403 T9400 dobj pathway,repressed
R7734 T9404 T9400 prep at,repressed
R7735 T9413 T9410 pobj domain,with
R7736 T9405 T9406 amod transcriptional,level
R7737 T9406 T9404 pobj level,at
R7738 T9407 T9400 prep by,repressed
R7739 T9408 T9409 amod competitive,interaction
R7740 T9414 T9413 prep of,domain
R7741 T9409 T9407 pobj interaction,by
R7742 T9410 T9409 prep with,interaction
R7743 T9415 T9414 pobj CBP,of
R7744 T9416 T9415 cc or,CBP
R7745 T9417 T9419 amod local,hypoacetylation
R7746 T9449 T9446 punct ),kinase
R7747 T9418 T9419 compound histone,hypoacetylation
R7748 T9450 T9427 conj pathway,indicate
R7749 T9419 T9420 compound hypoacetylation,[
R7750 T9420 T9415 conj [,CBP
R7753 T9421 T9422 nummod 25,]
R7756 T9422 T9420 appos ],[
R7759 T9423 T9400 punct .,repressed
R7763 T9424 T9426 predet All,findings
R7765 T9425 T9426 det these,findings
R7766 T9426 T9427 nsubj findings,indicate
R7769 T9427 T9427 ROOT indicate,indicate
R7772 T9428 T9431 det the,crosstalk
R7778 T9429 T9431 amod potential,crosstalk
R7780 T9471 T9472 nummod 18,]
R7781 T9472 T9470 appos ],[
R7782 T9430 T9431 compound complicate,crosstalk
R7783 T9473 T9458 punct .,confirmed
R7784 T9474 T9496 prep In,reasoned
R7785 T9475 T9474 pobj view,In
R7786 T9431 T9427 dobj crosstalk,indicate
R7787 T9476 T9475 prep of,view
R7788 T9477 T9478 det the,fact
R7789 T9432 T9431 prep between,crosstalk
R7790 T9478 T9476 pobj fact,of
R7791 T9479 T9481 mark that,is
R7792 T9480 T9481 nsubj Nrf2,is
R7793 T9433 T9432 pobj NF-κB,between
R7794 T9481 T9478 acl is,fact
R7795 T9482 T9484 det a,factor
R7796 T9483 T9484 compound transcription,factor
R7797 T9434 T9433 cc and,NF-κB
R7798 T9484 T9481 attr factor,is
R7799 T9485 T9487 nsubj which,take
R7800 T9435 T9433 conj Nrf2,NF-κB
R7801 T9486 T9487 aux should,take
R7802 T9487 T9484 relcl take,factor
R7803 T9488 T9487 dobj function,take
R7804 T9436 T9433 punct ",",NF-κB
R7805 T9489 T9490 advmod mainly,in
R7806 T9490 T9487 prep in,take
R7807 T9437 T9440 nsubjpass which,regulated
R7808 T9491 T9490 pobj nucleus,in
R7809 T9492 T9496 punct ",",reasoned
R7810 T9493 T9496 nsubjpass it,reasoned
R7811 T9438 T9440 aux may,regulated
R7812 T9494 T9496 aux can,reasoned
R7813 T9495 T9496 auxpass be,reasoned
R7814 T9496 T9496 ROOT reasoned,reasoned
R7815 T9439 T9440 auxpass be,regulated
R7816 T9497 T9500 mark that,be
R7817 T9498 T9500 nsubj astrocytes,be
R7818 T9499 T9500 aux may,be
R7819 T9440 T9431 relcl regulated,crosstalk
R7820 T9500 T9496 ccomp be,reasoned
R7821 T9501 T9502 nummod one,kind
R7822 T9441 T9440 agent by,regulated
R7823 T9502 T9500 attr kind,be
R7824 T9503 T9502 prep of,kind
R7825 T9504 T9505 compound respondent,cells
R7826 T9505 T9503 pobj cells,of
R7827 T9506 T9502 prep in,kind
R7828 T9507 T9506 pobj activation,in
R7829 T9442 T9446 det the,kinase
R7830 T9508 T9507 prep of,activation
R7831 T9509 T9510 compound Nrf2-ARE,pathway
R7832 T9510 T9508 pobj pathway,of
R7833 T9511 T9500 prep after,be
R7834 T9443 T9446 amod upstream,kinase
R7835 T9512 T9511 pobj TBI,after
R7836 T9513 T9496 punct .,reasoned
R7837 T9444 T9445 amod mitogen-activated,protein
R7838 T9514 T9515 amod Previous,study
R7839 T9515 T9516 nsubj study,identified
R7840 T9445 T9446 compound protein,kinase
R7841 T9516 T9516 ROOT identified,identified
R7842 T9517 T9518 det the,expression
R7843 T9518 T9516 dobj expression,identified
R7844 T9446 T9441 pobj kinase,by
R7845 T9519 T9518 prep of,expression
R7846 T9520 T9519 pobj TNF-α,of
R7847 T9447 T9448 punct (,MAPKs
R7848 T9521 T9520 punct ",",TNF-α
R7849 T9522 T9520 conj IL-1β,TNF-α
R7850 T9523 T9522 punct ",",IL-1β
R7851 T9448 T9446 appos MAPKs,kinase
R7852 T9524 T9522 cc and,IL-1β
R7853 T9525 T9522 conj IL-6,IL-1β
R7854 T9526 T9516 prep in,identified
R7855 T9546 T9549 amod middle,occlusion
R7856 T9527 T9528 amod cultured,astrocytes
R7857 T9528 T9526 pobj astrocytes,in
R7858 T9529 T9516 prep after,identified
R7859 T9547 T9549 amod cerebral,occlusion
R7860 T9548 T9549 compound artery,occlusion
R7861 T9549 T9545 pobj occlusion,after
R7864 T9550 T9554 punct ",",observed
R7867 T9551 T9552 amod MMP9-positive,astrocytes
R7871 T9552 T9554 nsubjpass astrocytes,observed
R7874 T9553 T9554 auxpass were,observed
R7875 T9554 T9543 ccomp observed,revealed
R7876 T9539 T9535 appos ],[
R7877 T9540 T9516 punct .,identified
R7878 T9541 T9542 det Another,study
R7879 T9542 T9543 nsubj study,revealed
R7880 T9543 T9543 ROOT revealed,revealed
R7881 T9555 T9554 prep in,observed
R7882 T9544 T9554 mark that,observed
R7883 T9545 T9554 prep after,observed
R7884 T9556 T9557 compound brain,tissues
R7885 T9557 T9555 pobj tissues,in
R7886 T9558 T9554 agent by,observed
R7887 T9559 T9560 compound immunohistochemistry,[
R7888 T9560 T9558 pobj [,by
R7889 T9561 T9562 nummod 29,]
R7890 T9643 T9642 pobj TNF-α,of
R7891 T9562 T9560 appos ],[
R7892 T9644 T9643 punct ",",TNF-α
R7893 T9645 T9643 conj IL-1β,TNF-α
R7894 T9563 T9543 punct .,revealed
R7895 T9646 T9645 punct ",",IL-1β
R7896 T9647 T9645 conj IL-6,IL-1β
R7897 T9648 T9647 punct ",",IL-6
R7898 T9564 T9565 det Those,results
R7899 T9565 T9566 nsubj results,indicate
R7900 T9566 T9566 ROOT indicate,indicate
R7901 T9649 T9647 cc and,IL-6
R7902 T9567 T9568 det the,role
R7903 T9650 T9647 conj MMP9,IL-6
R7904 T9651 T9634 advcl resulting,induced
R7905 T9568 T9566 dobj role,indicate
R7906 T9652 T9651 prep in,resulting
R7907 T9653 T9655 amod more,deaths
R7908 T9569 T9568 prep of,role
R7909 T9654 T9655 compound cell,deaths
R7910 T9655 T9652 pobj deaths,in
R7911 T9656 T9655 prep in,deaths
R7912 T9570 T9569 pobj astrocytes,of
R7913 T9657 T9656 pobj astrocytes,in
R7914 T9658 T9651 prep after,resulting
R7915 T9571 T9570 prep in,astrocytes
R7916 T9659 T9660 compound scratch,injury
R7917 T9660 T9658 pobj injury,after
R7918 T9661 T9634 punct .,induced
R7919 T9572 T9573 amod inflammatory,process
R7920 T9662 T9663 det These,results
R7921 T9663 T9664 nsubj results,suggest
R7922 T9573 T9571 pobj process,in
R7923 T9664 T9664 ROOT suggest,suggest
R7924 T9665 T9668 mark that,be
R7925 T9574 T9568 prep after,role
R7926 T9666 T9668 nsubj Nrf2,be
R7927 T9667 T9668 aux may,be
R7928 T9668 T9664 ccomp be,suggest
R7929 T9669 T9671 det an,target
R7930 T9670 T9671 amod important,target
R7931 T9671 T9668 attr target,be
R7932 T9575 T9576 compound brain,injury
R7933 T9672 T9671 prep for,target
R7934 T9673 T9674 amod anti-inflammatory,therapy
R7935 T9674 T9672 pobj therapy,for
R7936 T9576 T9574 pobj injury,after
R7937 T9675 T9668 prep after,be
R7938 T9676 T9675 pobj TBI,after
R7939 T9577 T9566 punct .,indicate
R7940 T9677 T9664 punct .,suggest
R7941 T9578 T9583 cc But,is
R7942 T9579 T9583 prep till,is
R7943 T9580 T9579 pcomp now,till
R7944 T9581 T9583 punct ",",is
R7945 T9582 T9583 expl there,is
R7946 T9583 T9583 ROOT is,is
R7947 T9584 T9585 det no,study
R7948 T9585 T9583 attr study,is
R7949 T9586 T9585 acl focused,study
R7950 T9587 T9586 prep on,focused
R7951 T9588 T9589 det the,relationship
R7952 T9589 T9587 pobj relationship,on
R7953 T9590 T9589 prep among,relationship
R7954 T9591 T9590 pobj astrocytes,among
R7955 T9592 T9589 punct ",",relationship
R7956 T9593 T9589 appos Nrf2,relationship
R7957 T9594 T9593 punct ",",Nrf2
R7958 T9595 T9589 cc and,relationship
R7959 T9596 T9597 amod proinflammatory,mediators
R7960 T9597 T9589 conj mediators,relationship
R7961 T9598 T9586 prep after,focused
R7964 T9599 T9598 pobj TBI,after
R7967 T9600 T9583 punct .,is
R7974 T9601 T9602 poss Our,results
R7985 T9602 T9603 nsubj results,demonstrated
R7989 T9603 T9603 ROOT demonstrated,demonstrated
R7991 T9604 T9606 det the,expression
R7994 T9605 T9606 amod upregulated,expression
R7995 T9606 T9603 dobj expression,demonstrated
R7996 T9607 T9606 prep of,expression
R7998 T9608 T9607 pobj TNF-α,of
R8000 T9609 T9608 punct ",",TNF-α
R8003 T9610 T9608 conj IL-1β,TNF-α
R8004 T9611 T9610 punct ",",IL-1β
R8005 T9612 T9610 conj IL-6,IL-1β
R8006 T9613 T9612 punct ",",IL-6
R8007 T9614 T9612 cc and,IL-6
R8009 T9615 T9612 conj MMP9,IL-6
R8014 T9616 T9615 prep in,MMP9
R8017 T9617 T9618 compound Nrf2,knockout
R8020 T9618 T9616 pobj knockout,in
R8024 T9619 T9606 appos astrocytes,expression
R8031 T9620 T9603 prep after,demonstrated
R8034 T9621 T9622 compound scratch,injury
R8036 T9622 T9620 pobj injury,after
R8038 T9623 T9622 prep for,injury
R8039 T9624 T9626 det the,time
R8043 T9625 T9626 amod first,time
R8047 T9626 T9623 pobj time,for
R8051 T9627 T9603 punct .,demonstrated
R8054 T9628 T9634 prep In,induced
R8055 T9629 T9628 pobj conclusion,In
R8057 T9630 T9634 punct ",",induced
R8058 T9631 T9634 nsubj depletion,induced
R8062 T9632 T9631 prep of,depletion
R8063 T9633 T9632 pobj Nrf2,of
R8064 T9634 T9634 ROOT induced,induced
R8065 T9635 T9636 det the,activation
R8067 T9636 T9634 dobj activation,induced
R8069 T9637 T9636 prep of,activation
R8072 T9638 T9637 pobj NF-κB,of
R8073 T9639 T9636 cc and,activation
R8074 T9640 T9641 det the,expression
R8075 T9641 T9636 conj expression,activation
R8082 T9642 T9641 prep of,expression
R7071 T8743 T8745 det The,study
R7072 T8744 T8745 amod present,study
R7073 T8745 T8746 nsubj study,demonstrated
R7074 T8746 T8746 ROOT demonstrated,demonstrated
R7075 T8747 T8750 mark that,induced
R7076 T8748 T8749 compound scratch,injury
R7077 T8749 T8750 nsubj injury,induced
R7078 T8750 T8746 ccomp induced,demonstrated
R7079 T8751 T8752 det the,upregulation
R7080 T8752 T8750 dobj upregulation,induced
R7081 T8753 T8752 prep of,upregulation
R7082 T8754 T8755 compound NF-κB,DNA
R7083 T8755 T8753 pobj DNA,of
R7084 T8756 T8757 amod binding,activity
R7085 T8757 T8753 pobj activity,of
R7086 T8758 T8757 cc and,activity
R7087 T8759 T8757 conj overexpression,activity
R7088 T8760 T8759 prep of,overexpression
R7089 T8761 T8760 pobj TNF-α,of
R7090 T8762 T8761 punct ",",TNF-α
R7151 T8823 T8821 punct ",",[
R7152 T8824 T8825 nummod 9,]
R7153 T8825 T8821 appos ],[
R7154 T8826 T8808 punct .,demonstrated
R7155 T8827 T8839 prep As,activated
R7156 T8828 T8830 det a,factor
R7157 T8829 T8830 compound transcript,factor
R7158 T8830 T8827 pobj factor,As
R7159 T8831 T8839 punct ",",activated
R7160 T8832 T8833 amod NF-κB,binds
R7161 T8833 T8839 nsubjpass binds,activated
R7162 T8834 T8833 prep with,binds
R7163 T8835 T8834 pobj DNA,with
R7164 T8836 T8839 mark once,activated
R7165 T8837 T8839 nsubjpass it,activated
R7166 T8838 T8839 auxpass was,activated
R7229 T8901 T8904 nsubjpass It,demonstrated
R7230 T8902 T8904 aux has,demonstrated
R7231 T8903 T8904 auxpass been,demonstrated
R7232 T8904 T8904 ROOT demonstrated,demonstrated
R7233 T8905 T8907 mark that,is
R7234 T8906 T8907 expl there,is
R7235 T8907 T8904 ccomp is,demonstrated
R7236 T8908 T8910 det an,loop
R7237 T8909 T8910 amod autoregulatory,loop
R7238 T8910 T8907 attr loop,is
R7239 T8911 T8910 prep among,loop
R7240 T8912 T8914 det these,mediators
R7241 T8913 T8914 amod proinflammatory,mediators
R7242 T8914 T8911 pobj mediators,among
R7243 T8915 T8904 punct .,demonstrated
R7244 T8916 T8922 prep For,are
R7245 T8917 T8916 pobj example,For
R7246 T8918 T8922 punct ",",are
R7247 T8919 T8922 nsubj TNF-α,are
R7308 T8980 T8977 prep to,induces
R7309 T8981 T8980 pobj brain,to
R7310 T8982 T8970 punct .,aggravates
R7311 T8983 T8984 nsubj It,is
R7312 T8984 T8984 ROOT is,is
R7313 T8985 T8987 det a,choice
R7314 T8986 T8987 amod good,choice
R7315 T8987 T8984 attr choice,is
R7316 T8988 T8987 prep for,choice
R7317 T8989 T8988 pcomp targeting,for
R7318 T8990 T8989 prep on,targeting
R7319 T8991 T8993 det an,factor
R7320 T8992 T8993 amod upstream,factor
R7321 T8993 T8990 pobj factor,on
R7322 T8994 T8995 aux to,prevent
R7323 T8995 T8993 acl prevent,factor
R7324 T8996 T8998 amod such,loop
R7325 T8997 T8998 amod autoregulatory,loop
R7326 T9025 T9024 punct ",",metabolites
R7372 T9057 T9056 prep of,transcription
R7373 T9058 T9059 det a,group
R7379 T9059 T9057 pobj group,of
R7380 T9060 T9059 prep of,group
R7382 T9061 T9062 amod antioxidant,genes
R7383 T9062 T9060 pobj genes,of
R7384 T9063 T9062 punct ",",genes
R7386 T9064 T9065 amod such,as
R7387 T9065 T9062 prep as,genes
R7389 T9066 T9067 compound heme,oxygenase-1
R7392 T9067 T9065 pobj oxygenase-1,as
R7393 T9068 T9069 punct (,HO-1
R7395 T9069 T9067 appos HO-1,oxygenase-1
R7396 T9070 T9069 punct ),HO-1
R7397 T9071 T9067 cc and,oxygenase-1
R7399 T9072 T9067 conj NAD,oxygenase-1
R7400 T9073 T9072 punct (,NAD
R7402 T9074 T9072 appos P,NAD
R7403 T9075 T9072 punct ),NAD
R7405 T9076 T9065 pobj H,as
R7406 T9077 T9055 punct :,activates
R7484 T9135 T9134 prep of,subfield
R7486 T9136 T9135 pobj hippocampus,of
R7487 T9137 T9113 prep after,decreases
R7489 T9138 T9139 compound TBI,[
R7490 T9139 T9141 nmod [,]
R7492 T9140 T9141 nummod 19,]
R7493 T9141 T9137 pobj ],after
R7494 T9142 T9107 punct .,improves
R7496 T9143 T9150 prep On,appear
R7497 T9144 T9146 det the,hand
R7404 T9156 T9159 nsubj Depletion,induces
R7408 T9157 T9156 prep of,Depletion
R7412 T9158 T9157 pobj Nrf2,of
R7416 T9159 T9159 ROOT induces,induces
R7419 T9160 T9161 amod higher,expression
R7425 T9161 T9159 dobj expression,induces
R7431 T9162 T9161 prep of,expression
R7435 T9163 T9164 amod proinflammatory,mediators
R7437 T9164 T9162 pobj mediators,of
R7440 T9165 T9159 prep in,induces
R7592 T9214 T9211 pobj mediators,of
R7594 T9215 T9194 conj led,aggravated
R7598 T9216 T9215 prep to,led
R7602 T9217 T9219 amod more,deaths
R7604 T9218 T9219 compound astrocytes,deaths
R7608 T9219 T9216 pobj deaths,to
R7611 T9220 T9177 punct .,revealed
R7615 T9221 T9222 nsubj Data,obtained
R7619 T9222 T9222 ROOT obtained,obtained
R7623 T9223 T9222 prep from,obtained
R7704 T9381 T9381 ROOT ],]
R7705 T9382 T9363 punct .,discovered
R7707 T9383 T9387 advmod Interestingly,reported
R7708 T9384 T9387 punct ",",reported
R7709 T9385 T9387 nsubjpass it,reported
R7711 T9386 T9387 auxpass is,reported
R7712 T9387 T9387 ROOT reported,reported
R7713 T9388 T9391 mark that,inhibit
R7715 T9389 T9391 nsubj NF-κB,inhibit
R7751 T9451 T9453 nmod [,]
R7752 T9452 T9453 nummod 26,]
R7754 T9453 T9450 dobj ],pathway
R7755 T9454 T9427 punct .,indicate
R7757 T9455 T9458 nsubjpass It,confirmed
R7758 T9456 T9458 aux has,confirmed
R7760 T9457 T9458 auxpass been,confirmed
R7761 T9458 T9458 ROOT confirmed,confirmed
R7762 T9459 T9463 mark that,detected
R7764 T9460 T9463 nsubjpass Nrf2,detected
R7767 T9461 T9463 auxpass is,detected
R7768 T9462 T9463 advmod mainly,detected
R7770 T9463 T9458 ccomp detected,confirmed
R7771 T9464 T9463 prep in,detected
R7773 T9465 T9464 pobj nucleus,in
R7774 T9466 T9465 prep of,nucleus
R7775 T9467 T9466 pobj astrocytes,of
R7776 T9468 T9463 prep after,detected
R7777 T9469 T9470 compound TBI,[
R7779 T9470 T9468 pobj [,after
R7862 T9530 T9529 pobj treatment,after
R7863 T9531 T9530 prep with,treatment
R7865 T9532 T9531 pobj LPS,with
R7866 T9533 T9530 cc or,treatment
R7868 T9534 T9535 compound oxyhemoglobin,[
R7869 T9535 T9516 dobj [,identified
R7870 T9536 T9535 nummod 27,[
R7872 T9537 T9535 punct ",",[
R7873 T9538 T9539 nummod 28,]

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T8742 5250-5254 Protein denotes Nrf2
T8741 5086-5096 Positive_regulation denotes activation
T8740 5086-5096 Positive_regulation denotes activation
T8739 5086-5096 Positive_regulation denotes activation
T8738 5086-5096 Positive_regulation denotes activation
T8737 5074-5081 Positive_regulation denotes induced
T8736 5074-5081 Positive_regulation denotes induced
T8735 5074-5081 Positive_regulation denotes induced
T8734 5074-5081 Positive_regulation denotes induced
T8733 5074-5081 Positive_regulation denotes induced
T8732 5157-5166 Gene_expression denotes resulting
T8731 5157-5166 Gene_expression denotes resulting
T8730 5157-5166 Gene_expression denotes resulting
T8729 5157-5166 Gene_expression denotes resulting
T8728 5114-5124 Gene_expression denotes expression
T8727 5114-5124 Gene_expression denotes expression
T8726 5114-5124 Gene_expression denotes expression
T8725 5114-5124 Gene_expression denotes expression
T8694 4439-4443 Protein denotes IL-6
T8693 4428-4433 Protein denotes IL-1β
T8692 4421-4426 Protein denotes TNF-α
T8691 4335-4345 Positive_regulation denotes activation
T8690 4335-4345 Positive_regulation denotes activation
T8689 4354-4357 Protein denotes ARE
T8688 4349-4353 Protein denotes Nrf2
T8687 4184-4188 Protein denotes Nrf2
T8686 4109-4117 Gene_expression denotes detected
T8685 4094-4098 Protein denotes Nrf2
T8684 3986-3995 Regulation denotes regulated
T8683 3986-3995 Regulation denotes regulated
T8682 4046-4051 Protein denotes MAPKs
T8681 4012-4044 Protein denotes mitogen-activated protein kinase
T8680 3967-3971 Protein denotes Nrf2
T8679 3957-3962 Protein denotes NF-κB
T8678 3804-3815 Binding denotes interaction
T8677 3856-3863 Protein denotes histone
T8676 3843-3846 Protein denotes CBP
T8675 3825-3839 Protein denotes CH1-KIX domain
T8674 3752-3755 Protein denotes ARE
T8673 3747-3751 Protein denotes Nrf2
T8672 3715-3732 Protein denotes NF-κB p65 subunit
T8671 3676-3683 Negative_regulation denotes inhibit
T8670 3684-3688 Protein denotes Nrf2
T8669 3666-3671 Protein denotes NF-κB
T8668 3483-3493 Positive_regulation denotes activation
T8667 3474-3482 Positive_regulation denotes Enhanced
T8666 3584-3593 Negative_regulation denotes deficient
T8665 3483-3493 Positive_regulation denotes activation
T8664 3579-3583 Protein denotes Nrf2
T8663 3497-3502 Protein denotes NF-κB
T8662 3244-3251 Positive_regulation denotes induces
T8661 3252-3264 Positive_regulation denotes augmentation
T8660 3226-3235 Negative_regulation denotes depletion
T8659 3268-3273 Protein denotes NF-κB
T8658 3239-3243 Protein denotes Nrf2
T8657 3149-3152 Protein denotes SFN
T8656 3124-3128 Protein denotes Nrf2
T8655 3040-3045 Protein denotes NF-κB
T8654 2912-2919 Negative_regulation denotes inhibit
T8653 2912-2919 Negative_regulation denotes inhibit
T8652 2912-2919 Negative_regulation denotes inhibit
T8651 2912-2919 Negative_regulation denotes inhibit
T8650 2912-2919 Negative_regulation denotes inhibit
T8649 2974-2987 Localization denotes translocation
T8648 2974-2987 Localization denotes translocation
T8647 2974-2987 Localization denotes translocation
T8646 2966-2973 Entity denotes nuclear
T8645 2928-2943 Phosphorylation denotes phosphorylation
T8644 2928-2943 Phosphorylation denotes phosphorylation
T8643 3014-3019 Protein denotes NF-κB
T8642 2955-2957 Protein denotes κB
T8641 2948-2954 Protein denotes p65 NF
T8640 2924-2927 Protein denotes IκB
T8639 2920-2923 Protein denotes IKK
T8638 2885-2888 Protein denotes SFN
T8607 1846-1850 Protein denotes HO-1
T8606 1892-1896 Protein denotes NQO1
T8605 1828-1844 Protein denotes heme oxygenase-1
T8604 1758-1762 Protein denotes Nrf2
T8603 1687-1699 Positive_regulation denotes augmentation
T8602 1703-1707 Protein denotes Nrf2
T8601 1522-1531 Regulation denotes regulator
T8600 1480-1483 Protein denotes ARE
T8599 1475-1479 Protein denotes Nrf2
T8598 1214-1220 Positive_regulation denotes induce
T8597 1214-1220 Positive_regulation denotes induce
T8596 1117-1124 Positive_regulation denotes induces
T8595 1221-1231 Positive_regulation denotes activation
T8594 1125-1139 Positive_regulation denotes overexpression
T8593 1063-1074 Positive_regulation denotes stimulators
T8592 1063-1074 Positive_regulation denotes stimulators
T8591 1235-1240 Protein denotes NF-κB
T8590 1199-1204 Protein denotes IL-1β
T8589 1189-1194 Protein denotes TNF-α
T8588 1143-1147 Protein denotes MMP9
T8587 1112-1116 Protein denotes IL-6
T8586 1079-1083 Protein denotes MMP9
T8585 1046-1051 Protein denotes IL-1β
T8584 1036-1041 Protein denotes TNF-α
T8583 787-796 Positive_regulation denotes elevation
T8582 779-786 Positive_regulation denotes induced
T8581 779-786 Positive_regulation denotes induced
T8580 779-786 Positive_regulation denotes induced
T8579 828-842 Positive_regulation denotes overexpression
T8578 828-842 Gene_expression denotes overexpression
T8577 787-796 Positive_regulation denotes elevation
T8576 846-850 Protein denotes MMP9
T8575 800-805 Protein denotes NF-κB
T8574 585-592 Positive_regulation denotes induces
T8573 593-606 Transcription denotes transcription
T8572 687-691 Protein denotes IL-6
T8571 676-681 Protein denotes IL-1β
T8570 669-674 Protein denotes TNF-α
T8569 610-614 Protein denotes MMP9
T8568 538-543 Protein denotes NF-κB
T8567 448-457 Positive_regulation denotes activated
T8566 439-444 Protein denotes NF-κB
T8565 232-239 Positive_regulation denotes induced
T8564 278-288 Gene_expression denotes expression
T8563 321-325 Protein denotes Nrf2
T8562 259-264 Protein denotes NF-κB
T8561 65-72 Positive_regulation denotes induced
T8560 65-72 Positive_regulation denotes induced
T8559 65-72 Positive_regulation denotes induced
T8558 65-72 Positive_regulation denotes induced
T8557 77-89 Positive_regulation denotes upregulation
T8556 77-89 Positive_regulation denotes upregulation
T8555 77-89 Positive_regulation denotes upregulation
T8554 77-89 Positive_regulation denotes upregulation
T8553 65-72 Positive_regulation denotes induced
T8552 65-72 Positive_regulation denotes induced
T8551 65-72 Positive_regulation denotes induced
T8550 65-72 Positive_regulation denotes induced
T8549 65-72 Positive_regulation denotes induced
T8548 65-72 Positive_regulation denotes induced
T8547 65-72 Positive_regulation denotes induced
T8546 65-72 Positive_regulation denotes induced
T8545 124-138 Positive_regulation denotes overexpression
T8544 124-138 Positive_regulation denotes overexpression
T8543 124-138 Positive_regulation denotes overexpression
T8542 124-138 Positive_regulation denotes overexpression
T8541 124-138 Gene_expression denotes overexpression
T8540 124-138 Gene_expression denotes overexpression
T8539 124-138 Gene_expression denotes overexpression
T8538 124-138 Gene_expression denotes overexpression
T8537 166-170 Protein denotes MMP9
T8536 156-160 Protein denotes IL-6
T8535 149-154 Protein denotes IL-1β
T8534 142-147 Protein denotes TNF-α
T8533 93-98 Protein denotes NF-κB
T8637 2850-2855 Protein denotes NF-κB
T8636 2764-2768 Protein denotes Nrf2
T8635 2420-2434 Positive_regulation denotes overexpression
T8634 2420-2434 Positive_regulation denotes overexpression
T8633 2420-2434 Positive_regulation denotes overexpression
T8632 2420-2434 Gene_expression denotes overexpression
T8631 2420-2434 Gene_expression denotes overexpression
T8630 2420-2434 Gene_expression denotes overexpression
T8629 2520-2524 Protein denotes Nrf2
T8628 2452-2456 Protein denotes IL-6
T8627 2445-2450 Protein denotes IL-1β
T8626 2438-2443 Protein denotes TNF-α
T8625 2290-2299 Negative_regulation denotes Depletion
T8624 2303-2307 Protein denotes Nrf2
T8623 2243-2252 Negative_regulation denotes deficient
T8622 2238-2242 Protein denotes Nrf2
T8611 1773-1786 Transcription denotes transcription
T8610 1773-1786 Transcription denotes transcription
T8609 1773-1786 Transcription denotes transcription
T8608 1740-1748 Positive_regulation denotes Enhanced
T8621 2060-2069 Negative_regulation denotes decreases
T8620 2060-2069 Negative_regulation denotes decreases
T8619 2060-2069 Negative_regulation denotes decreases
T8618 1994-2001 Positive_regulation denotes inducer
T8617 1994-2001 Positive_regulation denotes inducer
T8616 2005-2009 Protein denotes Nrf2
T8615 1986-1989 Protein denotes SFN
T8614 1763-1772 Positive_regulation denotes activates
T8613 1763-1772 Positive_regulation denotes activates
T8612 1763-1772 Positive_regulation denotes activates
T8719 5128-5133 Protein denotes TNF-α
T8718 5100-5105 Protein denotes NF-κB
T8717 5069-5073 Protein denotes Nrf2
T8716 4900-4912 Positive_regulation denotes demonstrated
T8715 4900-4912 Positive_regulation denotes demonstrated
T8714 4900-4912 Positive_regulation denotes demonstrated
T8713 4900-4912 Positive_regulation denotes demonstrated
T8712 4917-4928 Positive_regulation denotes upregulated
T8711 4917-4928 Positive_regulation denotes upregulated
T8710 4917-4928 Positive_regulation denotes upregulated
T8709 4917-4928 Positive_regulation denotes upregulated
T8708 4929-4939 Gene_expression denotes expression
T8707 4929-4939 Gene_expression denotes expression
T8706 4929-4939 Gene_expression denotes expression
T8705 4929-4939 Gene_expression denotes expression
T8704 4975-4979 Protein denotes Nrf2
T8703 4967-4971 Protein denotes MMP9
T8702 4957-4961 Protein denotes IL-6
T8701 4950-4955 Protein denotes IL-1β
T8700 4943-4948 Protein denotes TNF-α
T8699 4841-4845 Protein denotes Nrf2
T8698 4407-4417 Gene_expression denotes expression
T8697 4407-4417 Gene_expression denotes expression
T8696 4407-4417 Gene_expression denotes expression
T8695 4495-4508 Protein denotes oxyhemoglobin
T8724 5086-5096 Positive_regulation denotes activation
T8723 5056-5065 Negative_regulation denotes depletion
T8722 5152-5156 Protein denotes MMP9
T8721 5142-5146 Protein denotes IL-6
T8720 5135-5140 Protein denotes IL-1β
R6932 T8534 T8538 themeOf TNF-α,overexpression
R6933 T8535 T8539 themeOf IL-1β,overexpression
R6934 T8536 T8540 themeOf IL-6,overexpression
R6935 T8537 T8541 themeOf MMP9,overexpression
R6936 T8538 T8542 themeOf overexpression,overexpression
R6937 T8538 T8546 themeOf overexpression,induced
R6938 T8538 T8554 themeOf overexpression,upregulation
R6939 T8539 T8543 themeOf overexpression,overexpression
R6940 T8539 T8547 themeOf overexpression,induced
R6941 T8539 T8555 themeOf overexpression,upregulation
R6942 T8540 T8544 themeOf overexpression,overexpression
R6943 T8540 T8548 themeOf overexpression,induced
R6944 T8540 T8556 themeOf overexpression,upregulation
R6945 T8541 T8545 themeOf overexpression,overexpression
R6946 T8541 T8549 themeOf overexpression,induced
R6947 T8541 T8557 themeOf overexpression,upregulation
R6948 T8542 T8550 themeOf overexpression,induced
R6949 T8543 T8551 themeOf overexpression,induced
R6950 T8544 T8552 themeOf overexpression,induced
R6951 T8545 T8553 themeOf overexpression,induced
R6952 T8554 T8558 themeOf upregulation,induced
R6953 T8555 T8559 themeOf upregulation,induced
R6954 T8556 T8560 themeOf upregulation,induced
R6955 T8557 T8561 themeOf upregulation,induced
R6956 T8562 T8564 themeOf NF-κB,expression
R6957 T8564 T8565 themeOf expression,induced
R6958 T8566 T8567 themeOf NF-κB,activated
R6959 T8569 T8573 themeOf MMP9,transcription
R6960 T8573 T8574 themeOf transcription,induces
R6961 T8574 T8568 Cause induces,NF-κB
R6998 T8627 T8631 themeOf IL-1β,overexpression
R6999 T8628 T8632 themeOf IL-6,overexpression
R7000 T8630 T8633 themeOf overexpression,overexpression
R7001 T8631 T8634 themeOf overexpression,overexpression
R7002 T8632 T8635 themeOf overexpression,overexpression
R7003 T8639 T8644 themeOf IKK,phosphorylation
R7021 T8664 T8666 themeOf Nrf2,deficient
R7022 T8665 T8667 themeOf activation,Enhanced
R7023 T8667 T8668 themeOf Enhanced,activation
R7024 T8670 T8671 themeOf Nrf2,inhibit
R7025 T8671 T8669 Cause inhibit,NF-κB
R7026 T8676 T8678 themeOf CBP,interaction
R7027 T8679 T8683 themeOf NF-κB,regulated
R7028 T8680 T8684 themeOf Nrf2,regulated
R7029 T8685 T8686 themeOf Nrf2,detected
R7030 T8688 T8690 themeOf Nrf2,activation
R7031 T8689 T8691 themeOf ARE,activation
R7032 T8692 T8696 themeOf TNF-α,expression
R7033 T8693 T8697 themeOf IL-1β,expression
R7034 T8694 T8698 themeOf IL-6,expression
R7035 T8700 T8705 themeOf TNF-α,expression
R7036 T8701 T8706 themeOf IL-1β,expression
R7037 T8702 T8707 themeOf IL-6,expression
R7038 T8703 T8708 themeOf MMP9,expression
R7039 T8705 T8709 themeOf expression,upregulated
R7040 T8706 T8710 themeOf expression,upregulated
R7041 T8707 T8711 themeOf expression,upregulated
R7042 T8708 T8712 themeOf expression,upregulated
R7043 T8709 T8713 themeOf upregulated,demonstrated
R7044 T8710 T8714 themeOf upregulated,demonstrated
R7045 T8711 T8715 themeOf upregulated,demonstrated
R7046 T8712 T8716 themeOf upregulated,demonstrated
R7047 T8717 T8723 themeOf Nrf2,depletion
R7048 T8718 T8724 themeOf NF-κB,activation
R7049 T8719 T8725 themeOf TNF-α,expression
R7050 T8719 T8729 themeOf TNF-α,resulting
R7051 T8720 T8726 themeOf IL-1β,expression
R7052 T8720 T8730 themeOf IL-1β,resulting
R7053 T8721 T8727 themeOf IL-6,expression
R7054 T8721 T8731 themeOf IL-6,resulting
R7055 T8722 T8728 themeOf MMP9,expression
R7056 T8722 T8732 themeOf MMP9,resulting
R7057 T8724 T8733 themeOf activation,induced
R7058 T8725 T8734 themeOf expression,induced
R7060 T8726 T8735 themeOf expression,induced
R7066 T8733 T8723 Cause induced,depletion
R7067 T8734 T8723 Cause induced,depletion
R7068 T8735 T8723 Cause induced,depletion
R6962 T8575 T8577 themeOf NF-κB,elevation
R6963 T8576 T8578 themeOf MMP9,overexpression
R6964 T8577 T8580 themeOf elevation,induced
R6965 T8578 T8579 themeOf overexpression,overexpression
R6966 T8578 T8581 themeOf overexpression,induced
R6967 T8578 T8583 themeOf overexpression,elevation
R6968 T8579 T8582 themeOf overexpression,induced
R6969 T8586 T8592 themeOf MMP9,stimulators
R6970 T8586 T8593 themeOf MMP9,stimulators
R6971 T8588 T8594 themeOf MMP9,overexpression
R6972 T8591 T8595 themeOf NF-κB,activation
R6973 T8592 T8584 Cause stimulators,TNF-α
R6974 T8593 T8585 Cause stimulators,IL-1β
R6975 T8594 T8596 themeOf overexpression,induces
R6976 T8595 T8597 themeOf activation,induce
R6977 T8595 T8598 themeOf activation,induce
R6978 T8596 T8587 Cause induces,IL-6
R6979 T8597 T8589 Cause induce,TNF-α
R6980 T8598 T8590 Cause induce,IL-1β
R6981 T8600 T8601 themeOf ARE,regulator
R6982 T8602 T8603 themeOf Nrf2,augmentation
R6983 T8604 T8608 themeOf Nrf2,Enhanced
R6984 T8605 T8609 themeOf heme oxygenase-1,transcription
R6985 T8606 T8610 themeOf NQO1,transcription
R6986 T8607 T8611 themeOf HO-1,transcription
R6987 T8609 T8612 themeOf transcription,activates
R6988 T8610 T8613 themeOf transcription,activates
R6989 T8611 T8614 themeOf transcription,activates
R6990 T8615 T8617 themeOf SFN,inducer
R6991 T8615 T8619 themeOf SFN,decreases
R6992 T8616 T8618 themeOf Nrf2,inducer
R6993 T8617 T8620 themeOf inducer,decreases
R6994 T8618 T8621 themeOf inducer,decreases
R6995 T8622 T8623 themeOf Nrf2,deficient
R6996 T8624 T8625 themeOf Nrf2,Depletion
R6997 T8626 T8630 themeOf TNF-α,overexpression
R7004 T8639 T8647 themeOf IKK,translocation
R7005 T8640 T8645 themeOf IκB,phosphorylation
R7006 T8641 T8648 themeOf p65 NF,translocation
R7007 T8642 T8649 themeOf κB,translocation
R7008 T8644 T8650 themeOf phosphorylation,inhibit
R7009 T8645 T8651 themeOf phosphorylation,inhibit
R7010 T8647 T8646 ToLoc translocation,nuclear
R7011 T8647 T8652 themeOf translocation,inhibit
R7012 T8648 T8646 ToLoc translocation,nuclear
R7013 T8648 T8653 themeOf translocation,inhibit
R7014 T8649 T8646 ToLoc translocation,nuclear
R7015 T8649 T8654 themeOf translocation,inhibit
R7016 T8658 T8660 themeOf Nrf2,depletion
R7017 T8659 T8661 themeOf NF-κB,augmentation
R7018 T8661 T8662 themeOf augmentation,induces
R7019 T8662 T8660 Cause induces,depletion
R7020 T8663 T8665 themeOf NF-κB,activation
R7059 T8725 T8738 themeOf expression,activation
R7061 T8726 T8739 themeOf expression,activation
R7062 T8727 T8736 themeOf expression,induced
R7063 T8727 T8740 themeOf expression,activation
R7064 T8728 T8737 themeOf expression,induced
R7065 T8728 T8741 themeOf expression,activation
R7069 T8736 T8723 Cause induced,depletion
R7070 T8737 T8723 Cause induced,depletion

testone

Id Subject Object Predicate Lexical cue
T7107 5114-5124 Gene_expression denotes expression
T7106 5086-5096 Positive_regulation denotes activation
T7105 5074-5081 Positive_regulation denotes induced
T7104 5056-5065 Negative_regulation denotes depletion
T7103 4980-4988 Negative_regulation denotes knockout
T7102 4929-4939 Gene_expression denotes expression
T7101 4917-4928 Positive_regulation denotes upregulated
T7100 4407-4417 Gene_expression denotes expression
T7099 3986-3995 Regulation denotes regulated
T7098 3833-3839 Entity denotes domain
T7097 3804-3815 Binding denotes interaction
T7096 3733-3742 Negative_regulation denotes repressed
T7095 3676-3683 Negative_regulation denotes inhibit
T7094 3584-3593 Negative_regulation denotes deficient
T7093 3226-3235 Negative_regulation denotes depletion
T7092 3102-3112 Negative_regulation denotes attenuated
T7091 2974-2987 Localization denotes translocation
T7090 2966-2973 Entity denotes nuclear
T7089 2928-2943 Phosphorylation denotes phosphorylation
T7088 2912-2919 Negative_regulation denotes inhibit
T7087 2525-2533 Negative_regulation denotes knockout
T7086 2420-2434 Positive_regulation denotes overexpression
T7085 2290-2299 Negative_regulation denotes Depletion
T7084 2243-2252 Negative_regulation denotes deficient
T7083 544-549 Binding denotes binds
T7082 124-138 Positive_regulation denotes overexpression
T7081 77-89 Positive_regulation denotes upregulation
T7080 65-72 Positive_regulation denotes induced
T7079 5152-5156 Protein denotes MMP9
T7078 5142-5146 Protein denotes IL-6
T7077 5135-5140 Protein denotes IL-1β
T7076 4967-4971 Protein denotes MMP9
T7075 4957-4961 Protein denotes IL-6
T7074 4950-4955 Protein denotes IL-1β
T7073 4587-4591 Protein denotes MMP9
T7072 4439-4443 Protein denotes IL-6
T7071 4428-4433 Protein denotes IL-1β
T7070 3721-3724 Protein denotes p65
T7069 2948-2951 Protein denotes p65
T7068 2462-2466 Protein denotes MMP9
T7067 2452-2456 Protein denotes IL-6
T7066 2445-2450 Protein denotes IL-1β
T7065 1846-1850 Protein denotes HO-1
T7064 1828-1844 Protein denotes heme oxygenase-1
T7063 1199-1204 Protein denotes IL-1β
T7062 1143-1147 Protein denotes MMP9
T7061 1112-1116 Protein denotes IL-6
T7060 1079-1083 Protein denotes MMP9
T7059 1046-1051 Protein denotes IL-1β
T7058 846-850 Protein denotes MMP9
T7057 687-691 Protein denotes IL-6
T7056 676-681 Protein denotes IL-1β
T7055 610-614 Protein denotes MMP9
T7054 166-170 Protein denotes MMP9
T7053 156-160 Protein denotes IL-6
T7052 149-154 Protein denotes IL-1β
R5809 T7052 T7081 themeOf IL-1β,upregulation
R5810 T7052 T7082 themeOf IL-1β,overexpression
R5811 T7053 T7082 themeOf IL-6,overexpression
R5812 T7054 T7082 themeOf MMP9,overexpression
R5813 T7065 T7064 equivalentTo HO-1,heme oxygenase-1
R5814 T7066 T7086 themeOf IL-1β,overexpression
R5815 T7067 T7086 themeOf IL-6,overexpression
R5816 T7068 T7086 themeOf MMP9,overexpression
R5817 T7069 T7091 themeOf p65,translocation
R5818 T7070 T7097 themeOf p65,interaction
R5819 T7071 T7100 themeOf IL-1β,expression
R5820 T7072 T7100 themeOf IL-6,expression
R5821 T7074 T7102 themeOf IL-1β,expression
R5822 T7075 T7102 themeOf IL-6,expression
R5823 T7076 T7102 themeOf MMP9,expression
R5824 T7077 T7107 themeOf IL-1β,expression
R5825 T7078 T7107 themeOf IL-6,expression
R5826 T7079 T7107 themeOf MMP9,expression
R5827 T7081 T7080 themeOf upregulation,induced
R5828 T7089 T7088 themeOf phosphorylation,inhibit
R5829 T7090 T7091 locationOf nuclear,translocation
R5830 T7091 T7088 themeOf translocation,inhibit
R5831 T7097 T7096 causeOf interaction,repressed
R5832 T7102 T7101 themeOf expression,upregulated
R5833 T7106 T7105 themeOf activation,induced

test3

Id Subject Object Predicate Lexical cue
T7121 1846-1850 Protein denotes HO-1
T7120 1828-1844 Protein denotes heme oxygenase-1
T7119 1199-1204 Protein denotes IL-1β
T7118 1143-1147 Protein denotes MMP9
T7117 1112-1116 Protein denotes IL-6
T7116 1079-1083 Protein denotes MMP9
T7115 1046-1051 Protein denotes IL-1β
T7114 846-850 Protein denotes MMP9
T7113 687-691 Protein denotes IL-6
T7112 676-681 Protein denotes IL-1β
T7111 610-614 Protein denotes MMP9
T7110 166-170 Protein denotes MMP9
T7109 156-160 Protein denotes IL-6
T7108 149-154 Protein denotes IL-1β
T7193 5152-5156 Protein denotes MMP9
T7192 5142-5146 Protein denotes IL-6
T7191 5135-5140 Protein denotes IL-1β
T7190 5114-5124 Gene_expression denotes expression
T7189 5086-5096 Positive_regulation denotes activation
T7188 5074-5081 Positive_regulation denotes induced
T7187 5056-5065 Negative_regulation denotes depletion
T7186 4980-4988 Negative_regulation denotes knockout
T7185 4967-4971 Protein denotes MMP9
T7184 4957-4961 Protein denotes IL-6
T7183 4950-4955 Protein denotes IL-1β
T7182 4929-4939 Gene_expression denotes expression
T7181 4917-4928 Positive_regulation denotes upregulated
T7180 4587-4591 Protein denotes MMP9
T7179 4439-4443 Protein denotes IL-6
T7178 4428-4433 Protein denotes IL-1β
T7177 4407-4417 Gene_expression denotes expression
T7176 3986-3995 Regulation denotes regulated
T7175 3825-3832 Entity denotes CH1-KIX
T7174 3804-3815 Binding denotes interaction
T7173 3721-3724 Protein denotes p65
T7172 3676-3683 Negative_regulation denotes inhibit
T7171 3584-3593 Negative_regulation denotes deficient
T7170 2974-2987 Localization denotes translocation
T7169 2966-2973 Entity denotes nuclear
T7168 2948-2951 Protein denotes p65
T7167 2928-2943 Phosphorylation denotes phosphorylation
T7166 2912-2919 Negative_regulation denotes inhibit
T7165 2754-2760 Regulation denotes effect
T7164 2525-2533 Negative_regulation denotes knockout
T7163 2462-2466 Protein denotes MMP9
T7162 2452-2456 Protein denotes IL-6
T7161 2445-2450 Protein denotes IL-1β
T7160 2420-2434 Positive_regulation denotes overexpression
T7159 2243-2252 Negative_regulation denotes deficient
T7158 1994-2001 Positive_regulation denotes inducer
T7157 1846-1850 Protein denotes HO-1
T7156 1828-1844 Protein denotes heme oxygenase-1
T7155 1199-1204 Protein denotes IL-1β
T7154 1143-1147 Protein denotes MMP9
T7153 1125-1139 Positive_regulation denotes overexpression
T7152 1117-1124 Positive_regulation denotes induces
T7151 1112-1116 Protein denotes IL-6
T7150 1079-1083 Protein denotes MMP9
T7149 1046-1051 Protein denotes IL-1β
T7148 846-850 Protein denotes MMP9
T7147 828-842 Positive_regulation denotes overexpression
T7146 687-691 Protein denotes IL-6
T7145 676-681 Protein denotes IL-1β
T7144 610-614 Protein denotes MMP9
T7143 593-606 Transcription denotes transcription
T7142 585-592 Positive_regulation denotes induces
T7141 326-334 Negative_regulation denotes knockout
T7140 166-170 Protein denotes MMP9
T7139 156-160 Protein denotes IL-6
T7138 149-154 Protein denotes IL-1β
T7137 124-138 Positive_regulation denotes overexpression
T7136 103-110 Binding denotes binding
T7135 5152-5156 Protein denotes MMP9
T7134 5142-5146 Protein denotes IL-6
T7133 5135-5140 Protein denotes IL-1β
T7132 4967-4971 Protein denotes MMP9
T7131 4957-4961 Protein denotes IL-6
T7130 4950-4955 Protein denotes IL-1β
T7129 4587-4591 Protein denotes MMP9
T7128 4439-4443 Protein denotes IL-6
T7127 4428-4433 Protein denotes IL-1β
T7126 3721-3724 Protein denotes p65
T7125 2948-2951 Protein denotes p65
T7124 2462-2466 Protein denotes MMP9
T7123 2452-2456 Protein denotes IL-6
T7122 2445-2450 Protein denotes IL-1β
R5859 T7179 T7177 themeOf IL-6,expression
R5860 T7182 T7181 themeOf expression,upregulated
R5861 T7183 T7182 themeOf IL-1β,expression
R5862 T7184 T7182 themeOf IL-6,expression
R5863 T7185 T7182 themeOf MMP9,expression
R5864 T7189 T7188 themeOf activation,induced
R5865 T7191 T7190 themeOf IL-1β,expression
R5866 T7192 T7190 themeOf IL-6,expression
R5867 T7193 T7190 themeOf MMP9,expression
R5834 T7138 T7137 themeOf IL-1β,overexpression
R5835 T7138 T7136 themeOf IL-1β,binding
R5836 T7139 T7137 themeOf IL-6,overexpression
R5837 T7139 T7136 themeOf IL-6,binding
R5838 T7140 T7136 themeOf MMP9,binding
R5839 T7140 T7137 themeOf MMP9,overexpression
R5840 T7143 T7142 themeOf transcription,induces
R5841 T7144 T7143 themeOf MMP9,transcription
R5842 T7145 T7143 themeOf IL-1β,transcription
R5843 T7146 T7143 themeOf IL-6,transcription
R5844 T7148 T7147 themeOf MMP9,overexpression
R5845 T7151 T7152 causeOf IL-6,induces
R5846 T7153 T7152 themeOf overexpression,induces
R5847 T7154 T7153 themeOf MMP9,overexpression
R5848 T7157 T7156 equivalentTo HO-1,heme oxygenase-1
R5849 T7161 T7160 themeOf IL-1β,overexpression
R5850 T7162 T7160 themeOf IL-6,overexpression
R5851 T7163 T7160 themeOf MMP9,overexpression
R5852 T7167 T7166 themeOf phosphorylation,inhibit
R5853 T7168 T7170 themeOf p65,translocation
R5854 T7169 T7170 locationOf nuclear,translocation
R5855 T7170 T7166 themeOf translocation,inhibit
R5856 T7173 T7174 themeOf p65,interaction
R5857 T7175 T7174 themeOf CH1-KIX,interaction
R5858 T7178 T7177 themeOf IL-1β,expression