PMC:3312845 / 6715-8147 JSONTXT

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The infusion kit was sealed with dental cement and connected to an osmotic pump (1007D, Alzet, Cupertino, CA). The pump was placed in a subcutaneous pocket in the dorsal region. Animals received 0.5 μl/hr of vehicle or compound for 1 week. Therefore, the dose of sTNFp55R was 0.6 μg/day per each animal. The compounds began to be immediately infused after surgery. Since the volume of vasogenic edema peaked at 2-3 days after SE in our previous studies [5-8,20], we chose this time point. 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