PMC:3312845 / 28471-34035 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
22240205-3981213-63147438	316-318	3981213	denotes	12
22240205-3085437-63147439	319-321	3085437	denotes	13
22240205-15962509-63147440	322-324	15962509	denotes	15
22240205-3960307-63147441	325-327	3960307	denotes	16
22240205-15356194-63147442	328-330	15356194	denotes	28
22240205-3981213-63147443	454-456	3981213	denotes	12
22240205-3085437-63147444	457-459	3085437	denotes	13
22240205-15962509-63147445	460-462	15962509	denotes	15
22240205-3960307-63147446	463-465	3960307	denotes	16
22240205-15356194-63147447	466-468	15356194	denotes	28
22240205-3981213-63147448	576-578	3981213	denotes	12
22240205-3085437-63147449	579-581	3085437	denotes	13
22240205-15962509-63147450	582-584	15962509	denotes	15
22240205-3960307-63147451	585-587	3960307	denotes	16
22240205-15356194-63147452	588-590	15356194	denotes	28
22240205-21029730-63147453	1144-1145	21029730	denotes	5
22240205-2648633-63147453	1144-1145	2648633	denotes	5
22240205-21742016-63147453	1144-1145	21742016	denotes	5
22240205-20886625-63147453	1144-1145	20886625	denotes	5
22240205-9530927-63147454	1241-1243	9530927	denotes	29
22240205-15653325-63147455	1632-1634	15653325	denotes	30
22240205-3500474-63147456	1909-1911	3500474	denotes	31
22240205-21029730-63147457	1993-1994	21029730	denotes	5
22240205-21742016-63147458	1995-1996	21742016	denotes	7
22240205-20886625-63147459	1997-1998	20886625	denotes	8
22240205-15653325-63147460	1999-2001	15653325	denotes	30
22240205-2783587-63147461	2002-2004	2783587	denotes	32
22240205-9678508-63147462	2131-2133	9678508	denotes	33
22240205-9225736-63147463	2299-2301	9225736	denotes	34
22240205-11955477-63147464	2368-2370	11955477	denotes	35
22240205-7649815-63147464	2368-2370	7649815	denotes	35
22240205-2783587-63147464	2368-2370	2783587	denotes	35
22240205-20001970-63147465	2684-2686	20001970	denotes	39
22240205-21029730-63147466	2950-2951	21029730	denotes	5
22240205-20886625-63147467	2952-2953	20886625	denotes	8
22240205-8078878-63147468	2994-2996	8078878	denotes	40
22240205-9405476-63147469	3939-3941	9405476	denotes	41
22240205-20939924-63147470	4407-4409	20939924	denotes	20
22240205-10947836-63147471	4507-4509	10947836	denotes	42
22240205-7499865-63147472	4614-4616	7499865	denotes	43
22240205-20939924-63147473	4642-4644	20939924	denotes	20

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T12820	5559-5563	NN	denotes	loss
T12819	5539-5558	JJ	denotes	neuronal-astroglial
T12818	5535-5538	CC	denotes	and
T12817	5522-5534	NN	denotes	infiltration
T12816	5511-5521	NN	denotes	neutrophil
T12815	5508-5510	TO	denotes	to
T12814	5499-5507	JJ	denotes	relevant
T12813	5496-5498	VB	denotes	is
T12812	5490-5495	WDT	denotes	which
T12811	5488-5489	-COMMA-	denotes	,
T12810	5483-5488	NN	denotes	edema
T12809	5473-5482	JJ	denotes	vasogenic
T12808	5462-5472	JJ	denotes	SE-induced
T12807	5459-5461	IN	denotes	in
T12806	5450-5458	VB	denotes	involved
T12805	5447-5449	VB	denotes	be
T12804	5443-5446	MD	denotes	may
T12803	5427-5442	NN	denotes	phosphorylation
T12802	5421-5426	NN	denotes	NF-κB
T12801	5417-5420	CD	denotes	435
T12800	5409-5416	NN	denotes	p65-Thr
T12799	5400-5408	VB	denotes	mediated
T12798	5394-5399	NN	denotes	TNF-α
T12797	5390-5393	IN	denotes	via
T12796	5381-5389	NN	denotes	function
T12795	5376-5380	NN	denotes	cell
T12794	5364-5375	JJ	denotes	endothelial
T12793	5361-5363	IN	denotes	of
T12792	5349-5360	NN	denotes	impairments
T12791	5344-5348	IN	denotes	that
T12790	5337-5343	VB	denotes	reveal
T12282	2033-2045	JJ	denotes	pathological
T12281	2027-2032	JJ	denotes	above
T12280	2023-2026	DT	denotes	the
T12279	2020-2022	IN	denotes	of
T12278	2013-2019	NN	denotes	phases
T12277	2007-2012	JJ	denotes	Acute
T12276	2004-2005	-RRB-	denotes	]
T12275	1993-2004	CD	denotes	5,7,8,30,32
T12274	1992-1993	-LRB-	denotes	[
T12273	1986-1991	NN	denotes	cells
T12272	1974-1985	JJ	denotes	endothelial
T12271	1971-1973	IN	denotes	in
T12270	1966-1970	VB	denotes	lost
T12269	1963-1965	VB	denotes	is
T12268	1952-1962	NN	denotes	expression
T12267	1945-1951	NN	denotes	SMI-71
T12266	1943-1944	-COMMA-	denotes	,
T12265	1933-1943	NN	denotes	conditions
T12264	1920-1932	JJ	denotes	pathological
T12263	1914-1919	IN	denotes	Under
T12262	1911-1912	-RRB-	denotes	]
T12261	1909-1911	CD	denotes	31
T12260	1908-1909	-LRB-	denotes	[
T12259	1904-1907	NNP	denotes	BBB
T12258	1900-1903	NN	denotes	rat
T12257	1897-1899	IN	denotes	of
T12256	1891-1896	NN	denotes	cells
T12255	1879-1890	JJ	denotes	endothelial
T12254	1876-1878	IN	denotes	by
T12253	1866-1875	VB	denotes	expressed
T12252	1858-1865	NN	denotes	protein
T12251	1856-1857	DT	denotes	a
T12250	1853-1855	VB	denotes	is
T12249	1851-1852	-COMMA-	denotes	,
T12248	1844-1851	NN	denotes	antigen
T12247	1836-1843	NN	denotes	barrier
T12246	1824-1835	JJ	denotes	endothelial
T12245	1821-1823	DT	denotes	an
T12244	1819-1820	-COMMA-	denotes	,
T12243	1813-1819	NN	denotes	SMI-71
T12242	1801-1811	NN	denotes	expression
T12241	1794-1800	NN	denotes	SMI-71
T12240	1791-1793	IN	denotes	of
T12239	1784-1790	NN	denotes	degree
T12238	1780-1783	DT	denotes	the
T12237	1777-1779	TO	denotes	to
T12236	1765-1776	NN	denotes	correlation
T12235	1757-1764	JJ	denotes	inverse
T12234	1754-1756	DT	denotes	an
T12233	1747-1753	VB	denotes	showed
T12232	1730-1746	NN	denotes	immunoreactivity
T12231	1726-1729	PRP-DOLLAR-	denotes	its
T12230	1722-1725	CC	denotes	and
T12229	1720-1721	-COMMA-	denotes	,
T12228	1715-1720	NN	denotes	cells
T12227	1703-1714	JJ	denotes	endothelial
T12226	1700-1702	IN	denotes	in
T12225	1691-1699	VB	denotes	detected
T12224	1687-1690	VB	denotes	was
T12223	1670-1686	NN	denotes	immunoreactivity
T12222	1659-1669	NN	denotes	p65-Thr435
T12221	1657-1658	-COMMA-	denotes	,
T12220	1652-1657	NN	denotes	study
T12219	1644-1651	JJ	denotes	present
T12218	1640-1643	DT	denotes	the
T12217	1637-1639	IN	denotes	In
T12216	1634-1635	-RRB-	denotes	]
T12215	1632-1634	CD	denotes	30
T12214	1631-1632	-LRB-	denotes	[
T12213	1623-1630	NN	denotes	nucleus
T12212	1619-1622	DT	denotes	the
T12211	1616-1618	CC	denotes	or
T12210	1606-1615	NN	denotes	cytoplasm
T12209	1602-1605	DT	denotes	the
T12208	1595-1601	CC	denotes	either
T12207	1592-1594	IN	denotes	in
T12206	1585-1591	VB	denotes	occurs
T12205	1569-1584	NN	denotes	phosphorylation
T12204	1565-1568	NN	denotes	p65
T12203	1561-1564	CC	denotes	and
T12202	1559-1560	-COMMA-	denotes	,
T12201	1550-1559	NN	denotes	potential
T12200	1534-1549	NN	denotes	transactivation
T12199	1530-1533	PRP-DOLLAR-	denotes	its
T12198	1521-1529	VB	denotes	enhances
T12197	1515-1520	NN	denotes	NF-κB
T12196	1512-1514	IN	denotes	of
T12195	1496-1511	NN	denotes	phosphorylation
T12194	1492-1495	NN	denotes	p65
T12193	1479-1490	NN	denotes	development
T12192	1473-1478	NN	denotes	edema
T12191	1463-1472	JJ	denotes	vasogenic
T12190	1460-1462	IN	denotes	in
T12189	1454-1459	NN	denotes	event
T12188	1445-1453	JJ	denotes	upstream
T12187	1438-1444	JJ	denotes	unique
T12186	1436-1437	DT	denotes	a
T12185	1433-1435	VB	denotes	be
T12184	1429-1432	RB	denotes	not
T12183	1425-1428	MD	denotes	may
T12182	1415-1424	NN	denotes	signaling
T12181	1409-1414	NN	denotes	TNF-α
T12180	1404-1408	IN	denotes	that
T12179	1396-1403	VB	denotes	suggest
T12178	1387-1395	NN	denotes	findings
T12177	1383-1386	PRP-DOLLAR-	denotes	our
T12176	1381-1382	-COMMA-	denotes	,
T12175	1372-1381	RB	denotes	Therefore
T12174	1368-1370	NN	denotes	PC
T12173	1364-1367	DT	denotes	the
T12172	1361-1363	IN	denotes	in
T12171	1354-1360	NN	denotes	damage
T12169	1341-1344	CC	denotes	and
T12168	1335-1340	NN	denotes	edema
T12167	1325-1334	JJ	denotes	vasogenic
T12166	1314-1324	JJ	denotes	SE-induced
T12165	1306-1313	VB	denotes	prevent
T12164	1295-1305	RB	denotes	completely
T12163	1291-1294	RB	denotes	not
T12162	1285-1290	MD	denotes	could
T12161	1276-1284	NN	denotes	infusion
T12160	1268-1275	NN	denotes	sTNFp55
T12159	1266-1267	-COMMA-	denotes	,
T12158	1261-1266	NN	denotes	study
T12157	1253-1260	JJ	denotes	present
T12156	1249-1252	DT	denotes	the
T12155	1246-1248	IN	denotes	In
T12154	1243-1244	-RRB-	denotes	]
T12153	1241-1243	CD	denotes	29
T12152	1240-1241	-LRB-	denotes	[
T12151	1233-1239	NN	denotes	models
T12150	1225-1232	NN	denotes	disease
T12149	1212-1224	JJ	denotes	experimental
T12148	1204-1211	JJ	denotes	various
T12147	1201-1203	IN	denotes	in
T12146	1188-1200	NN	denotes	permeability
T12145	1184-1187	NN	denotes	BBB
T12144	1174-1183	VB	denotes	increases
T12143	1164-1173	NN	denotes	signaling
T12142	1158-1163	NN	denotes	TNF-α
T12141	1156-1157	-COMMA-	denotes	,
T12140	1150-1156	RB	denotes	Indeed
T12139	1147-1148	-RRB-	denotes	]
T12138	1144-1147	CD	denotes	5-8
T12137	1143-1144	-LRB-	denotes	[
T12136	1133-1142	NN	denotes	formation
T12135	1127-1132	NN	denotes	edema
T12134	1117-1126	JJ	denotes	vasogenic
T12133	1106-1116	JJ	denotes	SE-induced
T12132	1103-1105	TO	denotes	to
T12131	1094-1102	JJ	denotes	relevant
T12130	1090-1093	VB	denotes	are
T12129	1084-1089	WDT	denotes	which
T12128	1082-1083	-COMMA-	denotes	,
T12127	1080-1082	NN	denotes	SE
T12126	1077-1079	TO	denotes	to
T12125	1067-1076	NN	denotes	responses
T12124	1055-1066	JJ	denotes	endothelial
T12123	1051-1054	CC	denotes	and
T12122	1040-1050	JJ	denotes	astroglial
T12121	1037-1039	IN	denotes	in
T12120	1025-1036	VB	denotes	participate
T12119	1021-1024	MD	denotes	may
T12118	1015-1020	NN	denotes	TNF-α
T12117	1010-1014	IN	denotes	that
T12116	1001-1009	VB	denotes	indicate
T12115	992-1000	NN	denotes	findings
T12114	986-991	DT	denotes	These
T12113	982-984	NN	denotes	PC
T12112	978-981	DT	denotes	the
T12111	975-977	IN	denotes	in
T12110	968-974	NN	denotes	damage
T12109	959-967	JJ	denotes	neuronal
T12108	955-958	CC	denotes	and
T12107	949-954	NN	denotes	edema
T12106	939-948	JJ	denotes	vasogenic
T12105	928-938	JJ	denotes	SE-induced
T12104	925-927	IN	denotes	of
T12103	917-924	NN	denotes	volumes
T12102	909-916	VB	denotes	reduced
T12101	907-908	-RRB-	denotes	)
T12100	897-907	RB	denotes	completely
T12099	893-896	RB	denotes	not
T12098	889-892	CC	denotes	but
T12097	888-889	-LRB-	denotes	(
T12096	876-887	RB	denotes	effectively
T12095	867-875	NN	denotes	infusion
T12094	859-866	NN	denotes	sTNFp55
T12093	856-858	IN	denotes	by
T12092	846-855	NN	denotes	signaling
T12091	840-845	NN	denotes	TNF-α
T12090	837-839	IN	denotes	of
T12089	828-836	NN	denotes	blockade
T12088	826-827	-COMMA-	denotes	,
T12087	815-826	RB	denotes	Furthermore
T12086	812-813	-RRB-	denotes	)
T12085	805-812	NN	denotes	TNFp75R
T12084	804-805	-LRB-	denotes	(
T12083	798-803	NN	denotes	cells
T12082	786-797	JJ	denotes	endothelial
T12081	782-785	CC	denotes	and
T12080	780-781	-RRB-	denotes	)
T12079	773-780	NN	denotes	TNFp75R
T12078	769-772	CC	denotes	and
T12077	761-768	NN	denotes	TNFp55R
T12076	760-761	-LRB-	denotes	(
T12075	749-759	NN	denotes	astrocytes
T12074	746-748	IN	denotes	in
T12073	733-745	VB	denotes	up-regulated
T12072	728-732	RB	denotes	also
T12071	723-727	VB	denotes	were
T12070	711-722	NN	denotes	expressions
T12069	702-710	NN	denotes	receptor
T12068	698-701	NN	denotes	TNF
T12067	694-696	NN	denotes	SE
T12049	576-590	CD	denotes	12,13,15,16,28
T12048	575-576	-LRB-	denotes	[
T12047	566-574	NN	denotes	epilepsy
T12046	563-565	IN	denotes	of
T12045	551-562	NN	denotes	progression
T12044	548-550	TO	denotes	to
T12043	536-547	VB	denotes	contributes
T12042	532-535	CC	denotes	and
T12041	516-531	NN	denotes	epileptogenesis
T12040	513-515	TO	denotes	to
T12039	507-512	VB	denotes	leads
T12038	503-506	NNP	denotes	BBB
T12037	499-502	DT	denotes	the
T12036	496-498	IN	denotes	of
T12035	484-495	NN	denotes	dysfunction
T12034	482-483	-COMMA-	denotes	,
T12033	471-482	RB	denotes	Furthermore
T12032	468-469	-RRB-	denotes	]
T12031	454-468	CD	denotes	12,13,15,16,28
T12030	453-454	-LRB-	denotes	[
T12029	447-452	NN	denotes	onset
T12028	439-446	NN	denotes	seizure
T12027	435-438	CC	denotes	and
T12026	417-434	NN	denotes	hyperexcitability
T12025	412-416	IN	denotes	with
T12024	401-411	VB	denotes	associated
T12023	398-400	VB	denotes	is
T12022	392-397	NN	denotes	space
T12021	378-391	JJ	denotes	extracellular
T12020	374-377	DT	denotes	the
T12019	369-373	IN	denotes	into
T12018	358-368	NN	denotes	components
T12017	344-357	JJ	denotes	serum-derived
T12016	341-343	IN	denotes	of
T12015	333-340	NN	denotes	Leakage
T12014	330-331	-RRB-	denotes	]
T12013	316-330	CD	denotes	12,13,15,16,28
T12012	315-316	-LRB-	denotes	[
T12011	306-314	NN	denotes	epilepsy
T12010	300-305	JJ	denotes	human
T12009	296-299	CC	denotes	and
T12008	283-295	JJ	denotes	experimental
T12007	280-282	IN	denotes	in
T12006	271-279	VB	denotes	reported
T12005	266-270	VB	denotes	been
T12004	262-265	VB	denotes	has
T12003	251-261	NN	denotes	disruption
T12002	247-250	NN	denotes	BBB
T12001	233-245	NN	denotes	infiltration
T12000	222-232	NN	denotes	neutrophil
T11999	219-221	IN	denotes	by
T11998	210-218	VB	denotes	followed
T11997	200-209	NN	denotes	formation
T11996	194-199	NN	denotes	edema
T12789	5328-5336	NN	denotes	findings
T12788	5324-5327	PRP-DOLLAR-	denotes	our
T12787	5322-5323	-COMMA-	denotes	,
T12786	5312-5322	NN	denotes	conclusion
T12785	5309-5311	IN	denotes	In
T12784	5300-5307	NN	denotes	regions
T12783	5294-5299	NN	denotes	brain
T12782	5288-5293	JJ	denotes	other
T12781	5281-5287	IN	denotes	unlike
T12780	5279-5280	-COMMA-	denotes	,
T12779	5277-5279	NN	denotes	PC
T12778	5273-5276	DT	denotes	the
T12777	5270-5272	IN	denotes	in
T12776	5265-5269	NN	denotes	loss
T12775	5245-5264	JJ	denotes	neuronal-astroglial
T12774	5239-5244	VB	denotes	evoke
T12773	5236-5238	TO	denotes	to
T12772	5229-5235	NN	denotes	injury
T12771	5223-5228	NN	denotes	press
T12770	5219-5222	CC	denotes	and
T12769	5206-5218	NN	denotes	infiltration
T12768	5195-5205	NN	denotes	neutrophil
T12767	5188-5194	VB	denotes	induce
T12766	5184-5187	MD	denotes	can
T12765	5178-5183	NN	denotes	TNF-α
T12764	5175-5177	IN	denotes	by
T12763	5167-5174	VB	denotes	induced
T12762	5161-5166	NN	denotes	edema
T12761	5151-5160	JJ	denotes	vasogenic
T12760	5146-5150	IN	denotes	that
T12759	5139-5145	JJ	denotes	likely
T12758	5129-5138	RB	denotes	therefore
T12757	5126-5128	VB	denotes	is
T12756	5123-5125	PRP	denotes	it
T12755	5121-5122	-COMMA-	denotes	,
T12754	5114-5121	NN	denotes	reports
T12753	5105-5113	JJ	denotes	previous
T12752	5101-5104	PRP-DOLLAR-	denotes	our
T12751	5097-5100	CC	denotes	and
T12750	5089-5096	JJ	denotes	present
T12749	5085-5088	DT	denotes	the
T12748	5082-5084	TO	denotes	to
T12747	5074-5081	NN	denotes	respect
T12746	5069-5073	IN	denotes	With
T12745	5061-5067	NN	denotes	manner
T12744	5043-5060	JJ	denotes	MIP-2-independent
T12743	5041-5042	DT	denotes	a
T12742	5038-5040	IN	denotes	in
T12741	5028-5037	NN	denotes	formation
T12740	5022-5027	NN	denotes	edema
T12739	5012-5021	JJ	denotes	vasogenic
T12738	5003-5011	VB	denotes	reducing
T12737	5000-5002	IN	denotes	by
T12736	4997-4999	NN	denotes	PC
T12735	4993-4996	DT	denotes	the
T12734	4990-4992	IN	denotes	in
T12733	4977-4989	NN	denotes	infiltration
T12732	4966-4976	NN	denotes	neutrophil
T12731	4956-4965	VB	denotes	inhibited
T12730	4944-4955	RB	denotes	effectively
T12729	4935-4943	NN	denotes	infusion
T12728	4926-4934	NN	denotes	sTNFp55R
T12727	4924-4925	-COMMA-	denotes	,
T12726	4919-4924	NN	denotes	study
T12725	4911-4918	JJ	denotes	present
T12724	4907-4910	DT	denotes	the
T12723	4904-4906	IN	denotes	In
T12722	4890-4902	NN	denotes	infiltration
T12721	4880-4889	NN	denotes	leukocyte
T12720	4873-4879	VB	denotes	affect
T12719	4869-4872	RB	denotes	not
T12718	4863-4868	MD	denotes	could
T12717	4854-4862	NN	denotes	infusion
T12716	4852-4853	-RRB-	denotes	)
T12715	4842-4852	NN	denotes	antagonist
T12714	4836-4841	NN	denotes	IL-1β
T12713	4833-4835	DT	denotes	an
T12712	4832-4833	-LRB-	denotes	(
T12711	4825-4831	NN	denotes	IL-1Ra
T12710	4821-4824	CC	denotes	nor
T12709	4802-4820	NN	denotes	agonist/antagonist
T12708	4793-4801	NN	denotes	receptor
T12707	4788-4792	NN	denotes	P2X7
T12706	4786-4787	DT	denotes	a
T12705	4778-4785	CC	denotes	neither
T12704	4776-4777	-COMMA-	denotes	,
T12703	4769-4776	RB	denotes	however
T12702	4767-4768	-COMMA-	denotes	,
T12701	4765-4767	NN	denotes	PC
T12700	4761-4764	DT	denotes	the
T12699	4758-4760	IN	denotes	In
T12698	4746-4756	NN	denotes	expression
T12697	4740-4745	NN	denotes	MIP-2
T12696	4722-4739	JJ	denotes	receptor-mediated
T12695	4717-4721	NN	denotes	P2X7
T12694	4714-4716	IN	denotes	by
T12693	4704-4713	VB	denotes	regulated
T12692	4700-4703	VB	denotes	was
T12691	4693-4699	NN	denotes	cortex
T12690	4678-4692	JJ	denotes	frontoparietal
T12689	4674-4677	DT	denotes	the
T12688	4671-4673	IN	denotes	in
T12687	4658-4670	NN	denotes	infiltration
T12686	4647-4657	NN	denotes	neutrophil
T12685	4645-4646	-COMMA-	denotes	,
T12684	4644-4645	-RRB-	denotes	]
T12683	4642-4644	CD	denotes	20
T12682	4641-4642	-LRB-	denotes	[
T12681	4635-4640	NN	denotes	study
T12680	4626-4634	JJ	denotes	previous
T12679	4622-4625	PRP-DOLLAR-	denotes	our
T12678	4619-4621	IN	denotes	In
T12677	4616-4617	-RRB-	denotes	]
T12676	4614-4616	CD	denotes	43
T12675	4613-4614	-LRB-	denotes	[
T12674	4602-4612	NN	denotes	parenchyma
T12673	4596-4601	NN	denotes	brain
T12672	4593-4595	TO	denotes	to
T12671	4581-4592	NN	denotes	recruitment
T12670	4570-4580	NN	denotes	lymphocyte
T12669	4567-4569	CC	denotes	or
T12668	4556-4566	NN	denotes	neutrophil
T12667	4546-4555	JJ	denotes	efficient
T12472	3287-3292	MD	denotes	would
T12471	3270-3286	NN	denotes	immunoreactivity
T12470	3266-3269	NN	denotes	SMI
T12469	3263-3265	IN	denotes	in
T12468	3255-3262	NN	denotes	changes
T12467	3253-3254	-COMMA-	denotes	,
T12466	3247-3253	NN	denotes	report
T12465	3238-3246	JJ	denotes	previous
T12464	3233-3237	DT	denotes	this
T12463	3230-3232	TO	denotes	to
T12462	3222-3229	NN	denotes	respect
T12461	3217-3221	IN	denotes	With
T12460	3199-3215	NN	denotes	immunoreactivity
T12459	3192-3198	NN	denotes	SMI-71
T12458	3189-3191	IN	denotes	of
T12457	3173-3188	NN	denotes	down-regulation
T12456	3169-3172	CC	denotes	and
T12455	3163-3168	NN	denotes	edema
T12454	3153-3162	JJ	denotes	vasogenic
T12453	3150-3152	IN	denotes	of
T12452	3139-3149	NN	denotes	appearance
T12451	3135-3138	DT	denotes	the
T12450	3132-3134	TO	denotes	to
T12449	3126-3131	JJ	denotes	prior
T12448	3123-3125	NN	denotes	SE
T12447	3117-3122	IN	denotes	after
T12446	3113-3116	NN	denotes	hrs
T12445	3110-3112	CD	denotes	12
T12444	3095-3109	VB	denotes	down-regulated
T12443	3091-3094	VB	denotes	was
T12442	3087-3090	CC	denotes	and
T12441	3085-3086	-COMMA-	denotes	,
T12440	3077-3085	NN	denotes	end-feet
T12439	3064-3076	JJ	denotes	perivascular
T12438	3053-3063	JJ	denotes	astrocytic
T12437	3050-3052	IN	denotes	in
T12436	3046-3049	CC	denotes	and
T12435	3038-3045	NN	denotes	vessels
T12434	3032-3037	NN	denotes	blood
T12433	3029-3031	IN	denotes	in
T12432	3020-3028	VB	denotes	detected
T12431	3016-3019	VB	denotes	was
T12430	2999-3015	NN	denotes	immunoreactivity
T12429	2997-2998	-RRB-	denotes	)
T12428	2996-2997	-RRB-	denotes	]
T12427	2994-2996	CD	denotes	40
T12426	2993-2994	-LRB-	denotes	[
T12425	2985-2992	NN	denotes	protein
T12424	2971-2984	JJ	denotes	actin-binding
T12423	2968-2970	DT	denotes	an
T12422	2967-2968	-LRB-	denotes	(
T12421	2956-2966	NN	denotes	dystrophin
T12420	2954-2955	-COMMA-	denotes	,
T12419	2953-2954	-RRB-	denotes	]
T12418	2950-2953	CD	denotes	5,8
T12417	2949-2950	-LRB-	denotes	[
T12416	2941-2948	NN	denotes	studies
T12415	2932-2940	JJ	denotes	previous
T12414	2928-2931	PRP-DOLLAR-	denotes	our
T12413	2925-2927	IN	denotes	In
T12412	2911-2923	NN	denotes	permeability
T12411	2907-2910	NN	denotes	BBB
T12410	2895-2906	VB	denotes	influencing
T12409	2883-2894	NN	denotes	dysfunction
T12408	2865-2882	JJ	denotes	posttranslational
T12407	2861-2864	PRP-DOLLAR-	denotes	its
T12406	2858-2860	CC	denotes	or
T12405	2846-2857	NN	denotes	degradation
T12404	2839-2845	NN	denotes	SMI-71
T12403	2835-2838	IN	denotes	via
T12402	2825-2834	NN	denotes	induction
T12401	2819-2824	NN	denotes	edema
T12400	2809-2818	JJ	denotes	vasogenic
T12399	2806-2808	IN	denotes	in
T12398	2801-2805	NN	denotes	role
T12397	2791-2800	JJ	denotes	important
T12396	2788-2790	DT	denotes	an
T12395	2783-2787	VB	denotes	play
T12394	2779-2782	MD	denotes	may
T12393	2773-2778	NN	denotes	cells
T12392	2761-2772	JJ	denotes	endothelial
T12391	2758-2760	IN	denotes	in
T12390	2742-2757	NN	denotes	phosphorylation
T12389	2731-2741	NN	denotes	p65-Thr435
T12388	2716-2730	JJ	denotes	TNF-α-mediated
T12387	2711-2715	IN	denotes	that
T12386	2702-2710	VB	denotes	indicate
T12385	2693-2701	NN	denotes	findings
T12384	2689-2692	PRP-DOLLAR-	denotes	our
T12383	2687-2688	-COMMA-	denotes	,
T12382	2686-2687	-RRB-	denotes	]
T12381	2684-2686	CD	denotes	39
T12380	2683-2684	-LRB-	denotes	[
T12379	2677-2682	NN	denotes	TNF-α
T12378	2674-2676	IN	denotes	by
T12377	2663-2673	NN	denotes	p65-Thr435
T12376	2660-2662	IN	denotes	of
T12375	2644-2659	NN	denotes	phosphorylation
T12374	2640-2643	DT	denotes	the
T12373	2637-2639	TO	denotes	to
T12372	2629-2636	NN	denotes	respect
T12371	2624-2628	IN	denotes	With
T12370	2607-2622	NN	denotes	down-regulation
T12369	2600-2606	NN	denotes	SMI-71
T12368	2589-2599	JJ	denotes	SE-induced
T12367	2579-2588	VB	denotes	prevented
T12366	2567-2578	RB	denotes	effectively
T12365	2558-2566	NN	denotes	infusion
T12363	2547-2548	-COMMA-	denotes	,
T12362	2536-2547	RB	denotes	Furthermore
T12361	2526-2534	VB	denotes	observed
T12360	2521-2525	VB	denotes	were
T12359	2514-2520	NN	denotes	damage
T12358	2505-2513	JJ	denotes	neuronal
T12357	2501-2504	CC	denotes	and
T12356	2495-2500	NN	denotes	edema
T12355	2485-2494	JJ	denotes	vasogenic
T12354	2480-2484	WRB	denotes	when
T12353	2477-2479	NN	denotes	SE
T12352	2471-2476	IN	denotes	after
T12351	2467-2470	NN	denotes	day
T12350	2465-2466	CD	denotes	1
T12349	2457-2464	NN	denotes	vessels
T12348	2451-2456	NN	denotes	blood
T12347	2448-2450	IN	denotes	in
T12346	2440-2447	VB	denotes	reduced
T12345	2426-2439	RB	denotes	significantly
T12344	2422-2425	VB	denotes	was
T12343	2405-2421	NN	denotes	immunoreactivity
T12342	2398-2404	NN	denotes	SMI-71
T12341	2396-2397	-COMMA-	denotes	,
T12340	2391-2396	NN	denotes	study
T12339	2383-2390	JJ	denotes	present
T12338	2379-2382	DT	denotes	the
T12337	2376-2378	IN	denotes	In
T12336	2373-2374	-RRB-	denotes	]
T12335	2368-2373	CD	denotes	35-38
T12334	2367-2368	-LRB-	denotes	[
T12333	2357-2366	NN	denotes	junctions
T12332	2352-2356	NN	denotes	cell
T12331	2340-2351	JJ	denotes	endothelial
T12330	2337-2339	IN	denotes	at
T12329	2327-2336	VB	denotes	localized
T12328	2323-2326	RB	denotes	not
T12327	2320-2322	VB	denotes	is
T12326	2313-2319	NN	denotes	SMI-71
T12325	2304-2312	IN	denotes	although
T12324	2302-2303	-COMMA-	denotes	,
T12323	2301-2302	-RRB-	denotes	]
T12322	2299-2301	CD	denotes	34
T12321	2298-2299	-LRB-	denotes	[
T12320	2288-2297	NN	denotes	processes
T12319	2277-2287	JJ	denotes	astrocytic
T12318	2264-2276	JJ	denotes	perivascular
T12317	2261-2263	IN	denotes	of
T12316	2252-2260	NN	denotes	swelling
T12315	2248-2251	CC	denotes	and
T12314	2242-2247	NN	denotes	cells
T12313	2230-2241	JJ	denotes	endothelial
T12312	2222-2229	IN	denotes	between
T12311	2212-2221	NN	denotes	junctions
T12310	2198-2211	JJ	denotes	intercellular
T12309	2195-2197	IN	denotes	of
T12308	2186-2194	NN	denotes	widening
T12307	2183-2185	TO	denotes	to
T12306	2177-2182	VB	denotes	leads
T12305	2172-2176	FW	denotes	vivo
T12304	2169-2171	FW	denotes	in
T12303	2162-2168	NN	denotes	SMI-71
T12302	2159-2161	IN	denotes	of
T12301	2144-2158	NN	denotes	neutralization
T12300	2142-2143	-COMMA-	denotes	,
T12299	2136-2142	RB	denotes	Indeed
T12298	2133-2134	-RRB-	denotes	]
T12297	2131-2133	CD	denotes	33
T12296	2130-2131	-LRB-	denotes	[
T12295	2124-2129	NN	denotes	edema
T12294	2114-2123	JJ	denotes	vasogenic
T12293	2111-2113	IN	denotes	of
T12292	2099-2110	NN	denotes	development
T12291	2095-2098	CC	denotes	and
T12290	2091-2094	NN	denotes	BBB
T12289	2087-2090	DT	denotes	the
T12288	2084-2086	IN	denotes	of
T12287	2076-2083	NN	denotes	opening
T12286	2073-2075	IN	denotes	by
T12285	2061-2072	VB	denotes	accompanied
T12284	2057-2060	VB	denotes	are
T12283	2046-2056	NN	denotes	conditions
T11995	184-193	JJ	denotes	vasogenic
T11994	181-183	TO	denotes	to
T11993	173-180	JJ	denotes	related
T11992	170-172	VB	denotes	be
T11991	166-169	MD	denotes	may
T11990	160-165	WDT	denotes	which
T11989	158-159	-COMMA-	denotes	,
T11988	156-158	NN	denotes	SE
T11987	146-155	VB	denotes	following
T11986	143-145	NN	denotes	PC
T11985	139-142	DT	denotes	the
T11984	136-138	IN	denotes	in
T11983	120-135	NN	denotes	phosphorylation
T11982	114-119	NN	denotes	NF-κB
T11981	111-113	IN	denotes	of
T11980	101-110	NN	denotes	responses
T11979	92-100	JJ	denotes	specific
T11978	83-91	JJ	denotes	cellular
T11977	76-82	VB	denotes	showed
T11976	66-75	NN	denotes	signaling
T11975	60-65	NN	denotes	TNF-α
T11974	55-59	IN	denotes	that
T11973	51-54	VB	denotes	are
T11972	45-50	NN	denotes	study
T11971	37-44	JJ	denotes	present
T11970	33-36	DT	denotes	the
T11969	30-32	IN	denotes	in
T11968	21-29	NN	denotes	findings
T11967	15-20	JJ	denotes	major
T11966	11-14	DT	denotes	The
T12645	4433-4442	NN	denotes	synthesis
T12644	4423-4432	VB	denotes	increases
T12643	4415-4422	RB	denotes	rapidly
T12642	4412-4414	NN	denotes	SE
T12641	4409-4410	-RRB-	denotes	]
T12640	4407-4409	CD	denotes	20
T12639	4406-4407	-LRB-	denotes	[
T12638	4395-4405	RB	denotes	thereafter
T12637	4384-4394	VB	denotes	disappears
T12636	4380-4383	CC	denotes	and
T12635	4378-4379	-RRB-	denotes	)
T12634	4376-4378	NN	denotes	SE
T12633	4370-4375	IN	denotes	after
T12632	4367-4369	NN	denotes	hr
T12631	4364-4366	CD	denotes	36
T12630	4362-4363	-COLON-	denotes	-
T12629	4360-4361	CD	denotes	4
T12628	4359-4360	-LRB-	denotes	(
T12627	4356-4358	NN	denotes	SE
T12626	4353-4355	IN	denotes	of
T12625	4347-4352	NN	denotes	phase
T12624	4341-4346	JJ	denotes	acute
T12623	4337-4340	DT	denotes	the
T12622	4330-4336	IN	denotes	during
T12621	4321-4329	VB	denotes	observed
T12620	4309-4320	RB	denotes	transiently
T12619	4306-4308	VB	denotes	is
T12618	4295-4305	NN	denotes	parenchyma
T12617	4289-4294	NN	denotes	brain
T12616	4284-4288	IN	denotes	into
T12615	4271-4283	NN	denotes	infiltration
T12614	4260-4270	NN	denotes	Neutrophil
T12613	4246-4258	NN	denotes	permeability
T12612	4242-4245	NN	denotes	BBB
T12611	4239-4241	IN	denotes	of
T12610	4227-4238	NN	denotes	maintenance
T12609	4223-4226	DT	denotes	the
T12608	4220-4222	IN	denotes	in
T12607	4215-4219	NN	denotes	role
T12606	4213-4214	-RRB-	denotes	)
T12605	4203-4213	NN	denotes	astrocytes
T12604	4200-4202	IN	denotes	by
T12603	4199-4200	-LRB-	denotes	(
T12602	4190-4198	JJ	denotes	indirect
T12601	4187-4189	CC	denotes	or
T12600	4185-4186	-RRB-	denotes	)
T12599	4180-4185	NN	denotes	cells
T12598	4168-4179	JJ	denotes	endothelial
T12597	4165-4167	IN	denotes	by
T12596	4164-4165	-LRB-	denotes	(
T12595	4157-4163	JJ	denotes	direct
T12594	4155-4156	DT	denotes	a
T12593	4148-4154	CC	denotes	either
T12592	4143-4147	VB	denotes	play
T12591	4140-4142	TO	denotes	to
T12590	4129-4139	NN	denotes	synergists
T12589	4126-4128	VB	denotes	be
T12588	4122-4125	MD	denotes	may
T12587	4116-4121	NN	denotes	IL-1β
T12586	4112-4115	CC	denotes	and
T12585	4106-4111	NN	denotes	TNF-α
T12584	4101-4105	CC	denotes	both
T12583	4096-4100	IN	denotes	that
T12582	4087-4095	VB	denotes	indicate
T12581	4078-4086	NN	denotes	findings
T12580	4074-4077	PRP-DOLLAR-	denotes	our
T12579	4072-4073	-COMMA-	denotes	,
T12578	4063-4072	RB	denotes	Therefore
T12577	4056-4061	NN	denotes	edema
T12576	4046-4055	JJ	denotes	vasogenic
T12575	4035-4045	JJ	denotes	SE-induced
T12574	4032-4034	IN	denotes	in
T12573	4027-4031	NN	denotes	role
T12572	4025-4026	DT	denotes	a
T12571	4020-4024	VB	denotes	play
T12570	4015-4019	RB	denotes	also
T12569	4011-4014	MD	denotes	may
T12568	3995-4010	NN	denotes	phosphorylation
T12567	3977-3994	NN	denotes	p65-Ser529/Ser536
T12566	3962-3976	JJ	denotes	IL-1β-mediated
T12565	3957-3961	IN	denotes	that
T12564	3950-3956	JJ	denotes	likely
T12563	3947-3949	VB	denotes	is
T12562	3944-3946	PRP	denotes	it
T12561	3942-3943	-COMMA-	denotes	,
T12560	3941-3942	-RRB-	denotes	]
T12559	3939-3941	CD	denotes	41
T12558	3938-3939	-LRB-	denotes	[
T12557	3932-3937	NN	denotes	IL-1β
T12556	3928-3931	CC	denotes	and
T12555	3922-3927	NN	denotes	TNF-α
T12554	3919-3921	IN	denotes	by
T12553	3904-3918	VB	denotes	phosphorylated
T12552	3900-3903	VB	denotes	are
T12551	3889-3899	NN	denotes	p65-Ser536
T12550	3885-3888	CC	denotes	and
T12549	3874-3884	NN	denotes	p65-Ser529
T12548	3868-3873	IN	denotes	Since
T12547	3859-3866	NN	denotes	insults
T12546	3856-3858	NN	denotes	SE
T12545	3851-3855	IN	denotes	from
T12544	3834-3850	NN	denotes	phosphorylations
T12543	3823-3833	NN	denotes	p65-Ser536
T12542	3819-3822	CC	denotes	and
T12541	3808-3818	NN	denotes	p65-Ser529
T12540	3800-3807	VB	denotes	prevent
T12539	3796-3799	RB	denotes	not
T12538	3790-3795	MD	denotes	could
T12537	3781-3789	NN	denotes	infusion
T12536	3772-3780	NN	denotes	sTNFp55R
T12535	3770-3771	-COMMA-	denotes	,
T12534	3763-3770	RB	denotes	However
T12533	3751-3761	NN	denotes	disruption
T12532	3747-3750	NN	denotes	BBB
T12531	3732-3746	JJ	denotes	TNF-α-mediated
T12530	3729-3731	IN	denotes	in
T12529	3720-3728	VB	denotes	involved
T12528	3717-3719	VB	denotes	be
T12527	3713-3716	MD	denotes	may
T12526	3697-3712	NN	denotes	phosphorylation
T12525	3686-3696	NN	denotes	p65-Ser311
T12524	3682-3685	CC	denotes	and
T12523	3671-3681	NN	denotes	p65-Ser276
T12522	3662-3670	VB	denotes	enhanced
T12521	3657-3661	IN	denotes	that
T12520	3650-3656	JJ	denotes	likely
T12519	3647-3649	VB	denotes	is
T12518	3644-3646	PRP	denotes	it
T12517	3642-3643	-COMMA-	denotes	,
T12516	3633-3642	RB	denotes	Therefore
T12515	3629-3631	NN	denotes	SE
T12514	3619-3628	VB	denotes	following
T12513	3608-3618	NN	denotes	astrocytes
T12512	3605-3607	IN	denotes	in
T12511	3579-3604	NN	denotes	p65-Ser311phosphorylation
T12510	3575-3578	CC	denotes	and
T12509	3564-3574	NN	denotes	p65-Ser276
T12508	3554-3563	VB	denotes	inhibited
T12507	3542-3553	RB	denotes	effectively
T12506	3533-3541	NN	denotes	infusion
T12505	3524-3532	NN	denotes	sTNFp55R
T12504	3522-3523	-COMMA-	denotes	,
T12503	3511-3522	RB	denotes	Furthermore
T12502	3507-3509	NN	denotes	SE
T12501	3497-3506	VB	denotes	following
T12500	3486-3496	NN	denotes	astrocytes
T12499	3483-3485	IN	denotes	in
T12498	3474-3482	VB	denotes	observed
T12497	3470-3473	VB	denotes	was
T12496	3454-3469	NN	denotes	phosphorylation
T12495	3443-3453	NN	denotes	p65-Ser536
T12494	3439-3442	CC	denotes	and
T12493	3437-3438	-COMMA-	denotes	,
T12492	3427-3437	NN	denotes	p65-Ser529
T12491	3425-3426	-COMMA-	denotes	,
T12490	3415-3425	NN	denotes	p65-Ser311
T12489	3413-3414	-COMMA-	denotes	,
T12488	3403-3413	NN	denotes	p65-Ser276
T12487	3401-3402	-COMMA-	denotes	,
T12486	3396-3401	NN	denotes	study
T12485	3388-3395	JJ	denotes	present
T12484	3384-3387	DT	denotes	the
T12483	3381-3383	IN	denotes	In
T12482	3369-3379	NN	denotes	astrocytes
T12481	3356-3368	JJ	denotes	perivascular
T12480	3352-3355	CC	denotes	and
T12479	3346-3351	NN	denotes	cells
T12478	3334-3345	JJ	denotes	endothelial
T12477	3326-3333	IN	denotes	between
T12476	3314-3325	NN	denotes	interaction
T12475	3311-3313	IN	denotes	of
T12474	3296-3310	NN	denotes	causes/results
T12473	3293-3295	VB	denotes	be
T12066	684-693	VB	denotes	following
T12065	681-683	NN	denotes	PC
T12064	677-680	DT	denotes	the
T12063	674-676	IN	denotes	in
T12062	664-673	NN	denotes	microglia
T12061	661-663	IN	denotes	in
T12060	652-660	VB	denotes	observed
T12059	642-651	RB	denotes	obviously
T12058	638-641	VB	denotes	was
T12057	621-637	NN	denotes	immunoreactivity
T12056	615-620	NN	denotes	TNF-α
T12055	613-614	-COMMA-	denotes	,
T12054	608-613	NN	denotes	study
T12053	600-607	JJ	denotes	present
T12052	596-599	DT	denotes	the
T12051	593-595	IN	denotes	In
T12050	590-591	-RRB-	denotes	]
T12666	4542-4545	IN	denotes	for
T12665	4533-4541	VB	denotes	required
T12664	4530-4532	VB	denotes	is
T12663	4524-4529	NN	denotes	MIP-2
T12662	4522-4523	-COMMA-	denotes	,
T12661	4518-4522	PRP	denotes	them
T12660	4512-4517	IN	denotes	Among
T12659	4509-4510	-RRB-	denotes	]
T12658	4507-4509	CD	denotes	42
T12657	4506-4507	-LRB-	denotes	[
T12656	4500-4505	NN	denotes	brain
T12655	4493-4499	NN	denotes	rodent
T12654	4489-4492	DT	denotes	the
T12653	4486-4488	IN	denotes	of
T12652	4480-4485	NN	denotes	areas
T12651	4472-4479	JJ	denotes	various
T12650	4469-4471	IN	denotes	in
T12649	4458-4468	NN	denotes	chemokines
T12648	4455-4457	IN	denotes	of
T12647	4447-4454	NN	denotes	release
T12646	4443-4446	CC	denotes	and
T12170	1345-1353	JJ	denotes	neuronal
T12364	2549-2557	NN	denotes	sTNFp55R
R9212	T11968	T11966	arg1Of	findings,The
R9213	T11968	T11967	arg1Of	findings,major
R9214	T11968	T11969	arg1Of	findings,in
R9215	T11968	T11973	arg1Of	findings,are
R9216	T11972	T11969	arg2Of	study,in
R9217	T11972	T11970	arg1Of	study,the
R9218	T11972	T11971	arg1Of	study,present
R9219	T11973	T11984	arg1Of	are,in
R9220	T11976	T11974	arg1Of	signaling,that
R9221	T11976	T11975	arg1Of	signaling,TNF-α
R9222	T11976	T11977	arg1Of	signaling,showed
R9223	T11977	T11973	arg2Of	showed,are
R9224	T11979	T11978	arg1Of	specific,cellular
R9225	T11980	T11977	arg2Of	responses,showed
R9226	T11980	T11979	arg1Of	responses,specific
R9227	T11980	T11981	arg1Of	responses,of
R9228	T11983	T11981	arg2Of	phosphorylation,of
R9229	T11983	T11982	arg1Of	phosphorylation,NF-κB
R9230	T11986	T11984	arg2Of	PC,in
R9231	T11986	T11985	arg1Of	PC,the
R9232	T11986	T11987	arg1Of	PC,following
R9233	T11986	T11989	arg1Of	PC,","
R9234	T11986	T11990	arg1Of	PC,which
R9235	T11986	T11991	arg1Of	PC,may
R9236	T11986	T11992	arg1Of	PC,be
R9237	T11986	T11993	arg1Of	PC,related
R9238	T11988	T11987	arg2Of	SE,following
R9239	T11992	T11991	arg2Of	be,may
R9240	T11993	T11992	arg2Of	related,be
R9241	T11993	T11994	arg1Of	related,to
R9242	T11997	T11994	arg2Of	formation,to
R9243	T11997	T11995	arg1Of	formation,vasogenic
R9244	T11997	T11996	arg1Of	formation,edema
R9245	T11997	T11998	arg2Of	formation,followed
R9246	T12001	T11998	arg1Of	infiltration,followed
R9247	T12001	T11999	arg2Of	infiltration,by
R9248	T12001	T12000	arg1Of	infiltration,neutrophil
R9249	T12003	T12002	arg1Of	disruption,BBB
R9250	T12003	T12004	arg1Of	disruption,has
R9251	T12003	T12005	arg1Of	disruption,been
R9252	T12003	T12006	arg2Of	disruption,reported
R9253	T12006	T12004	arg2Of	reported,has
R9254	T12006	T12005	arg2Of	reported,been
R9255	T12006	T12007	arg1Of	reported,in
R9256	T12008	T12009	arg1Of	experimental,and
R9257	T12010	T12009	arg2Of	human,and
R9258	T12011	T12007	arg2Of	epilepsy,in
R9259	T12011	T12008	arg1Of	epilepsy,experimental
R9260	T12011	T12010	arg1Of	epilepsy,human
R9261	T12011	T12012	arg1Of	epilepsy,[
R9262	T12013	T12012	arg2Of	"12,13,15,16,28",[
R9263	T12014	T12012	arg3Of	],[
R9264	T12015	T12016	arg1Of	Leakage,of
R9265	T12015	T12019	arg1Of	Leakage,into
R9266	T12015	T12023	arg1Of	Leakage,is
R9267	T12015	T12024	arg2Of	Leakage,associated
R9268	T12018	T12016	arg2Of	components,of
R9269	T12018	T12017	arg1Of	components,serum-derived
R9270	T12022	T12019	arg2Of	space,into
R9271	T12022	T12020	arg1Of	space,the
R9272	T12022	T12021	arg1Of	space,extracellular
R9273	T12024	T12023	arg2Of	associated,is
R9274	T12024	T12025	arg1Of	associated,with
R9275	T12026	T12027	arg1Of	hyperexcitability,and
R9276	T12027	T12025	arg2Of	and,with
R9277	T12029	T12027	arg2Of	onset,and
R9278	T12029	T12028	arg1Of	onset,seizure
R9279	T12029	T12030	arg1Of	onset,[
R9280	T12031	T12030	arg2Of	"12,13,15,16,28",[
R9281	T12032	T12030	arg3Of	],[
R9282	T12035	T12036	arg1Of	dysfunction,of
R9283	T12035	T12039	arg1Of	dysfunction,leads
R9284	T12035	T12043	arg1Of	dysfunction,contributes
R9285	T12038	T12036	arg2Of	BBB,of
R9286	T12038	T12037	arg1Of	BBB,the
R9287	T12039	T12040	arg1Of	leads,to
R9288	T12039	T12042	arg1Of	leads,and
R9289	T12041	T12040	arg2Of	epileptogenesis,to
R9290	T12042	T12033	arg1Of	and,Furthermore
R9291	T12042	T12034	arg1Of	and,","
R9292	T12043	T12042	arg2Of	contributes,and
R9293	T12043	T12044	arg1Of	contributes,to
R9294	T12043	T12048	arg1Of	contributes,[
R9295	T12045	T12044	arg2Of	progression,to
R9296	T12045	T12046	arg1Of	progression,of
R9297	T12047	T12046	arg2Of	epilepsy,of
R9298	T12049	T12048	arg2Of	"12,13,15,16,28",[
R9299	T12050	T12048	arg3Of	],[
R9300	T12054	T12051	arg2Of	study,In
R9301	T12054	T12052	arg1Of	study,the
R9302	T12054	T12053	arg1Of	study,present
R9303	T12057	T12056	arg1Of	immunoreactivity,TNF-α
R9304	T12057	T12058	arg1Of	immunoreactivity,was
R9305	T12057	T12060	arg2Of	immunoreactivity,observed
R9306	T12060	T12051	arg1Of	observed,In
R9307	T12060	T12055	arg1Of	observed,","
R9308	T12060	T12058	arg2Of	observed,was
R9309	T12060	T12059	arg1Of	observed,obviously
R9310	T12060	T12061	arg1Of	observed,in
R9311	T12062	T12061	arg2Of	microglia,in
R9312	T12062	T12063	arg1Of	microglia,in
R9313	T12065	T12063	arg2Of	PC,in
R9314	T12065	T12064	arg1Of	PC,the
R9315	T12065	T12066	arg1Of	PC,following
R9316	T12067	T12066	arg2Of	SE,following
R9317	T12070	T12068	arg1Of	expressions,TNF
R9318	T12070	T12069	arg1Of	expressions,receptor
R9319	T12070	T12071	arg1Of	expressions,were
R9320	T12070	T12073	arg2Of	expressions,up-regulated
R9321	T12073	T12071	arg2Of	up-regulated,were
R9322	T12073	T12072	arg1Of	up-regulated,also
R9323	T12073	T12074	arg1Of	up-regulated,in
R9324	T12075	T12076	arg1Of	astrocytes,(
R9325	T12075	T12081	arg1Of	astrocytes,and
R9326	T12077	T12078	arg1Of	TNFp55R,and
R9327	T12078	T12076	arg2Of	and,(
R9328	T12079	T12078	arg2Of	TNFp75R,and
R9329	T12080	T12076	arg3Of	),(
R9330	T12081	T12074	arg2Of	and,in
R9331	T12083	T12081	arg2Of	cells,and
R9332	T12083	T12082	arg1Of	cells,endothelial
R9333	T12083	T12084	arg1Of	cells,(
R9334	T12085	T12084	arg2Of	TNFp75R,(
R9335	T12086	T12084	arg3Of	),(
R9336	T12089	T12090	arg1Of	blockade,of
R9337	T12089	T12093	arg1Of	blockade,by
R9338	T12089	T12102	arg1Of	blockade,reduced
R9339	T12092	T12090	arg2Of	signaling,of
R9340	T12092	T12091	arg1Of	signaling,TNF-α
R9341	T12095	T12093	arg2Of	infusion,by
R9342	T12095	T12094	arg1Of	infusion,sTNFp55
R9343	T12098	T12099	arg1Of	but,not
R9344	T12100	T12097	arg1Of	completely,(
R9345	T12100	T12098	arg1Of	completely,but
R9346	T12102	T12087	arg1Of	reduced,Furthermore
R9347	T12102	T12088	arg1Of	reduced,","
R9348	T12102	T12096	arg1Of	reduced,effectively
R9349	T12102	T12100	arg1Of	reduced,completely
R9350	T12102	T12101	arg1Of	reduced,)
R9351	T12103	T12102	arg2Of	volumes,reduced
R9352	T12103	T12104	arg1Of	volumes,of
R9353	T12106	T12107	arg1Of	vasogenic,edema
R9354	T12106	T12108	arg1Of	vasogenic,and
R9355	T12109	T12108	arg2Of	neuronal,and
R9356	T12110	T12104	arg2Of	damage,of
R9357	T12110	T12105	arg1Of	damage,SE-induced
R9358	T12110	T12106	arg1Of	damage,vasogenic
R9359	T12110	T12109	arg1Of	damage,neuronal
R9360	T12110	T12111	arg1Of	damage,in
R9361	T12113	T12111	arg2Of	PC,in
R9362	T12113	T12112	arg1Of	PC,the
R9363	T12115	T12114	arg1Of	findings,These
R9364	T12115	T12116	arg1Of	findings,indicate
R9365	T12118	T12119	arg1Of	TNF-α,may
R9366	T12118	T12120	arg1Of	TNF-α,participate
R9367	T12120	T12116	arg2Of	participate,indicate
R9368	T12120	T12117	arg1Of	participate,that
R9369	T12120	T12119	arg2Of	participate,may
R9370	T12120	T12121	arg1Of	participate,in
R9371	T12122	T12123	arg1Of	astroglial,and
R9372	T12124	T12123	arg2Of	endothelial,and
R9373	T12125	T12121	arg2Of	responses,in
R9374	T12125	T12122	arg1Of	responses,astroglial
R9375	T12125	T12124	arg1Of	responses,endothelial
R9376	T12125	T12126	arg1Of	responses,to
R9377	T12125	T12128	arg1Of	responses,","
R9378	T12125	T12129	arg1Of	responses,which
R9379	T12125	T12130	arg1Of	responses,are
R9380	T12125	T12131	arg1Of	responses,relevant
R9381	T12127	T12126	arg2Of	SE,to
R9382	T12131	T12130	arg2Of	relevant,are
R9383	T12131	T12132	arg1Of	relevant,to
R9384	T12136	T12132	arg2Of	formation,to
R9385	T12136	T12133	arg1Of	formation,SE-induced
R9386	T12136	T12134	arg1Of	formation,vasogenic
R9387	T12136	T12135	arg1Of	formation,edema
R9388	T12136	T12137	arg1Of	formation,[
R9389	T12138	T12137	arg2Of	5-8,[
R9390	T12139	T12137	arg3Of	],[
R9391	T12143	T12142	arg1Of	signaling,TNF-α
R9392	T12143	T12144	arg1Of	signaling,increases
R9393	T12144	T12140	arg1Of	increases,Indeed
R9394	T12144	T12141	arg1Of	increases,","
R9395	T12146	T12144	arg2Of	permeability,increases
R9396	T12146	T12145	arg1Of	permeability,BBB
R9397	T12146	T12147	arg1Of	permeability,in
R9398	T12151	T12147	arg2Of	models,in
R9399	T12151	T12148	arg1Of	models,various
R9400	T12151	T12149	arg1Of	models,experimental
R9401	T12151	T12150	arg1Of	models,disease
R9402	T12151	T12152	arg1Of	models,[
R9403	T12153	T12152	arg2Of	29,[
R9404	T12154	T12152	arg3Of	],[
R9405	T12158	T12155	arg2Of	study,In
R9406	T12158	T12156	arg1Of	study,the
R9407	T12158	T12157	arg1Of	study,present
R9408	T12161	T12160	arg1Of	infusion,sTNFp55
R9409	T12161	T12162	arg1Of	infusion,could
R9410	T12161	T12165	arg1Of	infusion,prevent
R9411	T12165	T12155	arg1Of	prevent,In
R9412	T12165	T12159	arg1Of	prevent,","
R9413	T12165	T12162	arg2Of	prevent,could
R9414	T12165	T12163	arg1Of	prevent,not
R9415	T12165	T12164	arg1Of	prevent,completely
R9416	T12167	T12166	arg1Of	vasogenic,SE-induced
R9417	T12167	T12168	arg1Of	vasogenic,edema
R9418	T12167	T12169	arg1Of	vasogenic,and
R9419	T12170	T12169	arg2Of	neuronal,and
R9420	T12171	T12165	arg2Of	damage,prevent
R9421	T12171	T12167	arg1Of	damage,vasogenic
R9422	T12171	T12170	arg1Of	damage,neuronal
R9423	T12171	T12172	arg1Of	damage,in
R9424	T12174	T12172	arg2Of	PC,in
R9425	T12174	T12173	arg1Of	PC,the
R9426	T12178	T12177	arg1Of	findings,our
R9427	T12178	T12179	arg1Of	findings,suggest
R9428	T12179	T12175	arg1Of	suggest,Therefore
R9429	T12179	T12176	arg1Of	suggest,","
R9430	T12182	T12181	arg1Of	signaling,TNF-α
R9431	T12182	T12183	arg1Of	signaling,may
R9432	T12182	T12185	arg1Of	signaling,be
R9433	T12185	T12179	arg2Of	be,suggest
R9434	T12185	T12180	arg1Of	be,that
R9435	T12185	T12183	arg2Of	be,may
R9436	T12185	T12184	arg1Of	be,not
R9437	T12189	T12185	arg2Of	event,be
R9438	T12189	T12186	arg1Of	event,a
R9439	T12189	T12187	arg1Of	event,unique
R9440	T12189	T12188	arg1Of	event,upstream
R9441	T12189	T12190	arg1Of	event,in
R9442	T12193	T12190	arg2Of	development,in
R9443	T12193	T12191	arg1Of	development,vasogenic
R9444	T12193	T12192	arg1Of	development,edema
R9445	T12195	T12194	arg1Of	phosphorylation,p65
R9446	T12195	T12196	arg1Of	phosphorylation,of
R9447	T12195	T12198	arg1Of	phosphorylation,enhances
R9448	T12197	T12196	arg2Of	NF-κB,of
R9449	T12198	T12203	arg1Of	enhances,and
R9450	T12201	T12198	arg2Of	potential,enhances
R9451	T12201	T12199	arg1Of	potential,its
R9452	T12201	T12200	arg1Of	potential,transactivation
R9453	T12203	T12202	arg1Of	and,","
R9454	T12205	T12204	arg1Of	phosphorylation,p65
R9455	T12205	T12206	arg1Of	phosphorylation,occurs
R9456	T12206	T12203	arg2Of	occurs,and
R9457	T12206	T12207	arg1Of	occurs,in
R9458	T12206	T12214	arg1Of	occurs,[
R9459	T12210	T12209	arg1Of	cytoplasm,the
R9460	T12210	T12211	arg1Of	cytoplasm,or
R9461	T12211	T12207	arg2Of	or,in
R9462	T12211	T12208	arg1Of	or,either
R9463	T12213	T12211	arg2Of	nucleus,or
R9464	T12213	T12212	arg1Of	nucleus,the
R9465	T12215	T12214	arg2Of	30,[
R9466	T12216	T12214	arg3Of	],[
R9467	T12220	T12217	arg2Of	study,In
R9468	T12220	T12218	arg1Of	study,the
R9469	T12220	T12219	arg1Of	study,present
R9470	T12223	T12222	arg1Of	immunoreactivity,p65-Thr435
R9471	T12223	T12224	arg1Of	immunoreactivity,was
R9472	T12223	T12225	arg2Of	immunoreactivity,detected
R9473	T12225	T12217	arg1Of	detected,In
R9474	T12225	T12221	arg1Of	detected,","
R9475	T12225	T12224	arg2Of	detected,was
R9476	T12225	T12226	arg1Of	detected,in
R9477	T12225	T12230	arg1Of	detected,and
R9478	T12228	T12226	arg2Of	cells,in
R9479	T12228	T12227	arg1Of	cells,endothelial
R9480	T12230	T12229	arg1Of	and,","
R9481	T12232	T12231	arg1Of	immunoreactivity,its
R9482	T12232	T12233	arg1Of	immunoreactivity,showed
R9483	T12233	T12230	arg2Of	showed,and
R9484	T12233	T12237	arg1Of	showed,to
R9485	T12236	T12233	arg2Of	correlation,showed
R9486	T12236	T12234	arg1Of	correlation,an
R9487	T12236	T12235	arg1Of	correlation,inverse
R9488	T12239	T12237	arg2Of	degree,to
R9489	T12239	T12238	arg1Of	degree,the
R9490	T12239	T12240	arg1Of	degree,of
R9491	T12242	T12240	arg2Of	expression,of
R9492	T12242	T12241	arg1Of	expression,SMI-71
R9493	T12243	T12244	arg1Of	SMI-71,","
R9494	T12243	T12250	arg1Of	SMI-71,is
R9495	T12248	T12244	arg2Of	antigen,","
R9496	T12248	T12245	arg1Of	antigen,an
R9497	T12248	T12246	arg1Of	antigen,endothelial
R9498	T12248	T12247	arg1Of	antigen,barrier
R9499	T12250	T12249	arg1Of	is,","
R9500	T12252	T12250	arg2Of	protein,is
R9501	T12252	T12251	arg1Of	protein,a
R9502	T12252	T12253	arg2Of	protein,expressed
R9503	T12256	T12253	arg1Of	cells,expressed
R9504	T12256	T12254	arg2Of	cells,by
R9505	T12256	T12255	arg1Of	cells,endothelial
R9506	T12256	T12257	arg1Of	cells,of
R9507	T12259	T12257	arg2Of	BBB,of
R9508	T12259	T12258	arg1Of	BBB,rat
R9509	T12259	T12260	arg1Of	BBB,[
R9510	T12261	T12260	arg2Of	31,[
R9511	T12262	T12260	arg3Of	],[
R9512	T12265	T12263	arg2Of	conditions,Under
R9513	T12265	T12264	arg1Of	conditions,pathological
R9514	T12268	T12267	arg1Of	expression,SMI-71
R9515	T12268	T12269	arg1Of	expression,is
R9516	T12268	T12270	arg2Of	expression,lost
R9517	T12270	T12263	arg1Of	lost,Under
R9518	T12270	T12266	arg1Of	lost,","
R9519	T12270	T12269	arg2Of	lost,is
R9520	T12270	T12271	arg1Of	lost,in
R9521	T12270	T12274	arg1Of	lost,[
R9522	T12273	T12271	arg2Of	cells,in
R9523	T12273	T12272	arg1Of	cells,endothelial
R9524	T12275	T12274	arg2Of	"5,7,8,30,32",[
R9525	T12276	T12274	arg3Of	],[
R9526	T12278	T12277	arg1Of	phases,Acute
R9527	T12278	T12279	arg1Of	phases,of
R9528	T12278	T12284	arg1Of	phases,are
R9529	T12278	T12285	arg2Of	phases,accompanied
R9530	T12283	T12279	arg2Of	conditions,of
R9531	T12283	T12280	arg1Of	conditions,the
R9532	T12283	T12281	arg1Of	conditions,above
R9533	T12283	T12282	arg1Of	conditions,pathological
R9534	T12285	T12284	arg2Of	accompanied,are
R9535	T12285	T12296	arg1Of	accompanied,[
R9536	T12287	T12288	arg1Of	opening,of
R9537	T12287	T12291	arg1Of	opening,and
R9538	T12290	T12288	arg2Of	BBB,of
R9539	T12290	T12289	arg1Of	BBB,the
R9540	T12291	T12285	arg1Of	and,accompanied
R9541	T12291	T12286	arg2Of	and,by
R9542	T12292	T12291	arg2Of	development,and
R9543	T12292	T12293	arg1Of	development,of
R9544	T12295	T12293	arg2Of	edema,of
R9545	T12295	T12294	arg1Of	edema,vasogenic
R9546	T12297	T12296	arg2Of	33,[
R9547	T12298	T12296	arg3Of	],[
R9548	T12301	T12302	arg1Of	neutralization,of
R9549	T12301	T12305	arg1Of	neutralization,vivo
R9550	T12301	T12306	arg1Of	neutralization,leads
R9551	T12303	T12302	arg2Of	SMI-71,of
R9552	T12305	T12304	arg1Of	vivo,in
R9553	T12306	T12299	arg1Of	leads,Indeed
R9554	T12306	T12300	arg1Of	leads,","
R9555	T12306	T12307	arg1Of	leads,to
R9556	T12306	T12324	arg1Of	leads,","
R9557	T12306	T12325	arg1Of	leads,although
R9558	T12308	T12309	arg1Of	widening,of
R9559	T12308	T12315	arg1Of	widening,and
R9560	T12311	T12309	arg2Of	junctions,of
R9561	T12311	T12310	arg1Of	junctions,intercellular
R9562	T12311	T12312	arg1Of	junctions,between
R9563	T12314	T12312	arg2Of	cells,between
R9564	T12314	T12313	arg1Of	cells,endothelial
R9565	T12315	T12307	arg2Of	and,to
R9566	T12316	T12315	arg2Of	swelling,and
R9567	T12316	T12317	arg1Of	swelling,of
R9568	T12320	T12317	arg2Of	processes,of
R9569	T12320	T12318	arg1Of	processes,perivascular
R9570	T12320	T12319	arg1Of	processes,astrocytic
R9571	T12320	T12321	arg1Of	processes,[
R9572	T12322	T12321	arg2Of	34,[
R9573	T12323	T12321	arg3Of	],[
R9574	T12326	T12327	arg1Of	SMI-71,is
R9575	T12326	T12329	arg2Of	SMI-71,localized
R9576	T12329	T12325	arg2Of	localized,although
R9577	T12329	T12327	arg2Of	localized,is
R9578	T12329	T12328	arg1Of	localized,not
R9579	T12329	T12330	arg1Of	localized,at
R9580	T12333	T12330	arg2Of	junctions,at
R9581	T12333	T12331	arg1Of	junctions,endothelial
R9582	T12333	T12332	arg1Of	junctions,cell
R9583	T12333	T12334	arg1Of	junctions,[
R9584	T12335	T12334	arg2Of	35-38,[
R9585	T12336	T12334	arg3Of	],[
R9586	T12340	T12337	arg2Of	study,In
R9587	T12340	T12338	arg1Of	study,the
R9588	T12340	T12339	arg1Of	study,present
R9589	T12343	T12342	arg1Of	immunoreactivity,SMI-71
R9590	T12343	T12344	arg1Of	immunoreactivity,was
R9591	T12343	T12346	arg2Of	immunoreactivity,reduced
R9592	T12346	T12337	arg1Of	reduced,In
R9593	T12346	T12341	arg1Of	reduced,","
R9594	T12346	T12344	arg2Of	reduced,was
R9595	T12346	T12345	arg1Of	reduced,significantly
R9596	T12346	T12347	arg1Of	reduced,in
R9597	T12346	T12352	arg1Of	reduced,after
R9598	T12346	T12354	arg1Of	reduced,when
R9599	T12349	T12347	arg2Of	vessels,in
R9600	T12349	T12348	arg1Of	vessels,blood
R9601	T12351	T12350	arg1Of	day,1
R9602	T12352	T12351	arg1Of	after,day
R9603	T12353	T12352	arg2Of	SE,after
R9604	T12355	T12356	arg1Of	vasogenic,edema
R9605	T12355	T12357	arg1Of	vasogenic,and
R9606	T12358	T12357	arg2Of	neuronal,and
R9607	T12359	T12355	arg1Of	damage,vasogenic
R9608	T12359	T12358	arg1Of	damage,neuronal
R9609	T12359	T12360	arg1Of	damage,were
R9610	T12359	T12361	arg2Of	damage,observed
R9611	T12361	T12354	arg2Of	observed,when
R9612	T12361	T12360	arg2Of	observed,were
R9613	T12365	T12364	arg1Of	infusion,sTNFp55R
R9614	T12365	T12367	arg1Of	infusion,prevented
R9615	T12367	T12362	arg1Of	prevented,Furthermore
R9616	T12367	T12363	arg1Of	prevented,","
R9617	T12367	T12366	arg1Of	prevented,effectively
R9618	T12370	T12367	arg2Of	down-regulation,prevented
R9619	T12370	T12368	arg1Of	down-regulation,SE-induced
R9620	T12370	T12369	arg1Of	down-regulation,SMI-71
R9621	T12371	T12373	arg1Of	With,to
R9622	T12372	T12371	arg2Of	respect,With
R9623	T12375	T12371	arg3Of	phosphorylation,With
R9624	T12375	T12374	arg1Of	phosphorylation,the
R9625	T12375	T12376	arg1Of	phosphorylation,of
R9626	T12375	T12378	arg1Of	phosphorylation,by
R9627	T12377	T12376	arg2Of	p65-Thr435,of
R9628	T12379	T12378	arg2Of	TNF-α,by
R9629	T12379	T12380	arg1Of	TNF-α,[
R9630	T12381	T12380	arg2Of	39,[
R9631	T12382	T12380	arg3Of	],[
R9632	T12385	T12384	arg1Of	findings,our
R9633	T12385	T12386	arg1Of	findings,indicate
R9634	T12386	T12371	arg1Of	indicate,With
R9635	T12386	T12383	arg1Of	indicate,","
R9636	T12390	T12388	arg1Of	phosphorylation,TNF-α-mediated
R9637	T12390	T12389	arg1Of	phosphorylation,p65-Thr435
R9638	T12390	T12391	arg1Of	phosphorylation,in
R9639	T12390	T12394	arg1Of	phosphorylation,may
R9640	T12390	T12395	arg1Of	phosphorylation,play
R9641	T12393	T12391	arg2Of	cells,in
R9642	T12393	T12392	arg1Of	cells,endothelial
R9643	T12395	T12386	arg2Of	play,indicate
R9644	T12395	T12387	arg1Of	play,that
R9645	T12395	T12394	arg2Of	play,may
R9646	T12395	T12399	arg1Of	play,in
R9647	T12398	T12395	arg2Of	role,play
R9648	T12398	T12396	arg1Of	role,an
R9649	T12398	T12397	arg1Of	role,important
R9650	T12402	T12400	arg1Of	induction,vasogenic
R9651	T12402	T12401	arg1Of	induction,edema
R9652	T12402	T12403	arg1Of	induction,via
R9653	T12402	T12406	arg1Of	induction,or
R9654	T12405	T12403	arg2Of	degradation,via
R9655	T12405	T12404	arg1Of	degradation,SMI-71
R9656	T12406	T12399	arg2Of	or,in
R9657	T12409	T12406	arg2Of	dysfunction,or
R9658	T12409	T12407	arg1Of	dysfunction,its
R9659	T12409	T12408	arg1Of	dysfunction,posttranslational
R9660	T12409	T12410	arg1Of	dysfunction,influencing
R9661	T12412	T12410	arg2Of	permeability,influencing
R9662	T12412	T12411	arg1Of	permeability,BBB
R9663	T12416	T12413	arg2Of	studies,In
R9664	T12416	T12414	arg1Of	studies,our
R9665	T12416	T12415	arg1Of	studies,previous
R9666	T12416	T12417	arg1Of	studies,[
R9667	T12418	T12417	arg2Of	"5,8",[
R9668	T12419	T12417	arg3Of	],[
R9669	T12421	T12422	arg1Of	dystrophin,(
R9670	T12425	T12422	arg2Of	protein,(
R9671	T12425	T12423	arg1Of	protein,an
R9672	T12425	T12424	arg1Of	protein,actin-binding
R9673	T12425	T12426	arg1Of	protein,[
R9674	T12427	T12426	arg2Of	40,[
R9675	T12428	T12426	arg3Of	],[
R9676	T12429	T12422	arg3Of	),(
R9677	T12430	T12421	arg1Of	immunoreactivity,dystrophin
R9678	T12430	T12431	arg1Of	immunoreactivity,was
R9679	T12430	T12432	arg2Of	immunoreactivity,detected
R9680	T12430	T12443	arg1Of	immunoreactivity,was
R9681	T12432	T12431	arg2Of	detected,was
R9682	T12432	T12433	arg1Of	detected,in
R9683	T12432	T12437	arg1Of	detected,in
R9684	T12432	T12442	arg1Of	detected,and
R9685	T12433	T12436	arg1Of	in,and
R9686	T12435	T12433	arg2Of	vessels,in
R9687	T12435	T12434	arg1Of	vessels,blood
R9688	T12437	T12436	arg2Of	in,and
R9689	T12440	T12437	arg2Of	end-feet,in
R9690	T12440	T12438	arg1Of	end-feet,astrocytic
R9691	T12440	T12439	arg1Of	end-feet,perivascular
R9692	T12442	T12413	arg1Of	and,In
R9693	T12442	T12420	arg1Of	and,","
R9694	T12442	T12441	arg1Of	and,","
R9695	T12443	T12442	arg2Of	was,and
R9696	T12443	T12447	arg1Of	was,after
R9697	T12446	T12443	arg2Of	hrs,was
R9698	T12446	T12444	arg2Of	hrs,down-regulated
R9699	T12446	T12445	arg1Of	hrs,12
R9700	T12448	T12447	arg2Of	SE,after
R9701	T12448	T12449	arg1Of	SE,prior
R9702	T12449	T12450	arg1Of	prior,to
R9703	T12452	T12450	arg2Of	appearance,to
R9704	T12452	T12451	arg1Of	appearance,the
R9705	T12452	T12453	arg1Of	appearance,of
R9706	T12455	T12454	arg1Of	edema,vasogenic
R9707	T12455	T12456	arg1Of	edema,and
R9708	T12456	T12453	arg2Of	and,of
R9709	T12457	T12456	arg2Of	down-regulation,and
R9710	T12457	T12458	arg1Of	down-regulation,of
R9711	T12460	T12458	arg2Of	immunoreactivity,of
R9712	T12460	T12459	arg1Of	immunoreactivity,SMI-71
R9713	T12461	T12463	arg1Of	With,to
R9714	T12462	T12461	arg2Of	respect,With
R9715	T12466	T12461	arg3Of	report,With
R9716	T12466	T12464	arg1Of	report,this
R9717	T12466	T12465	arg1Of	report,previous
R9718	T12468	T12469	arg1Of	changes,in
R9719	T12468	T12472	arg1Of	changes,would
R9720	T12468	T12473	arg1Of	changes,be
R9721	T12471	T12469	arg2Of	immunoreactivity,in
R9722	T12471	T12470	arg1Of	immunoreactivity,SMI
R9723	T12473	T12461	arg1Of	be,With
R9724	T12473	T12467	arg1Of	be,","
R9725	T12473	T12472	arg2Of	be,would
R9726	T12474	T12473	arg2Of	causes/results,be
R9727	T12474	T12475	arg1Of	causes/results,of
R9728	T12474	T12477	arg1Of	causes/results,between
R9729	T12476	T12475	arg2Of	interaction,of
R9730	T12479	T12478	arg1Of	cells,endothelial
R9731	T12479	T12480	arg1Of	cells,and
R9732	T12480	T12477	arg2Of	and,between
R9733	T12482	T12480	arg2Of	astrocytes,and
R9734	T12482	T12481	arg1Of	astrocytes,perivascular
R9735	T12486	T12483	arg2Of	study,In
R9736	T12486	T12484	arg1Of	study,the
R9737	T12486	T12485	arg1Of	study,present
R9738	T12488	T12489	arg1Of	p65-Ser276,","
R9739	T12489	T12491	arg1Of	",",","
R9740	T12490	T12489	arg2Of	p65-Ser311,","
R9741	T12491	T12494	arg1Of	",",and
R9742	T12492	T12491	arg2Of	p65-Ser529,","
R9743	T12494	T12493	arg1Of	and,","
R9744	T12494	T12497	arg1Of	and,was
R9745	T12494	T12498	arg2Of	and,observed
R9746	T12496	T12494	arg2Of	phosphorylation,and
R9747	T12496	T12495	arg1Of	phosphorylation,p65-Ser536
R9748	T12498	T12483	arg1Of	observed,In
R9749	T12498	T12487	arg1Of	observed,","
R9750	T12498	T12497	arg2Of	observed,was
R9751	T12498	T12499	arg1Of	observed,in
R9752	T12498	T12501	arg1Of	observed,following
R9753	T12500	T12499	arg2Of	astrocytes,in
R9754	T12502	T12501	arg2Of	SE,following
R9755	T12506	T12505	arg1Of	infusion,sTNFp55R
R9756	T12506	T12508	arg1Of	infusion,inhibited
R9757	T12508	T12503	arg1Of	inhibited,Furthermore
R9758	T12508	T12504	arg1Of	inhibited,","
R9759	T12508	T12507	arg1Of	inhibited,effectively
R9760	T12508	T12514	arg1Of	inhibited,following
R9761	T12509	T12510	arg1Of	p65-Ser276,and
R9762	T12510	T12508	arg2Of	and,inhibited
R9763	T12510	T12512	arg1Of	and,in
R9764	T12511	T12510	arg2Of	p65-Ser311phosphorylation,and
R9765	T12513	T12512	arg2Of	astrocytes,in
R9766	T12515	T12514	arg2Of	SE,following
R9767	T12518	T12519	arg1Of	it,is
R9768	T12518	T12520	arg1Of	it,likely
R9769	T12519	T12516	arg1Of	is,Therefore
R9770	T12519	T12517	arg1Of	is,","
R9771	T12520	T12519	arg2Of	likely,is
R9772	T12523	T12522	arg2Of	p65-Ser276,enhanced
R9773	T12523	T12524	arg1Of	p65-Ser276,and
R9774	T12524	T12527	arg1Of	and,may
R9775	T12524	T12528	arg1Of	and,be
R9776	T12524	T12529	arg2Of	and,involved
R9777	T12526	T12524	arg2Of	phosphorylation,and
R9778	T12526	T12525	arg1Of	phosphorylation,p65-Ser311
R9779	T12529	T12520	arg2Of	involved,likely
R9780	T12529	T12521	arg1Of	involved,that
R9781	T12529	T12527	arg2Of	involved,may
R9782	T12529	T12528	arg2Of	involved,be
R9783	T12529	T12530	arg1Of	involved,in
R9784	T12533	T12530	arg2Of	disruption,in
R9785	T12533	T12531	arg1Of	disruption,TNF-α-mediated
R9786	T12533	T12532	arg1Of	disruption,BBB
R9787	T12537	T12536	arg1Of	infusion,sTNFp55R
R9788	T12537	T12538	arg1Of	infusion,could
R9789	T12537	T12540	arg1Of	infusion,prevent
R9790	T12540	T12534	arg1Of	prevent,However
R9791	T12540	T12535	arg1Of	prevent,","
R9792	T12540	T12538	arg2Of	prevent,could
R9793	T12540	T12539	arg1Of	prevent,not
R9794	T12540	T12545	arg1Of	prevent,from
R9795	T12541	T12542	arg1Of	p65-Ser529,and
R9796	T12542	T12540	arg2Of	and,prevent
R9797	T12544	T12542	arg2Of	phosphorylations,and
R9798	T12544	T12543	arg1Of	phosphorylations,p65-Ser536
R9799	T12547	T12545	arg2Of	insults,from
R9800	T12547	T12546	arg1Of	insults,SE
R9801	T12549	T12550	arg1Of	p65-Ser529,and
R9802	T12550	T12552	arg1Of	and,are
R9803	T12550	T12553	arg2Of	and,phosphorylated
R9804	T12551	T12550	arg2Of	p65-Ser536,and
R9805	T12553	T12548	arg2Of	phosphorylated,Since
R9806	T12553	T12552	arg2Of	phosphorylated,are
R9807	T12555	T12556	arg1Of	TNF-α,and
R9808	T12556	T12553	arg1Of	and,phosphorylated
R9809	T12556	T12554	arg2Of	and,by
R9810	T12557	T12556	arg2Of	IL-1β,and
R9811	T12557	T12558	arg1Of	IL-1β,[
R9812	T12559	T12558	arg2Of	41,[
R9813	T12560	T12558	arg3Of	],[
R9814	T12562	T12563	arg1Of	it,is
R9815	T12562	T12564	arg1Of	it,likely
R9816	T12563	T12548	arg1Of	is,Since
R9817	T12563	T12561	arg1Of	is,","
R9818	T12564	T12563	arg2Of	likely,is
R9819	T12568	T12566	arg1Of	phosphorylation,IL-1β-mediated
R9820	T12568	T12567	arg1Of	phosphorylation,p65-Ser529/Ser536
R9821	T12568	T12569	arg1Of	phosphorylation,may
R9822	T12568	T12571	arg1Of	phosphorylation,play
R9823	T12571	T12564	arg2Of	play,likely
R9824	T12571	T12565	arg1Of	play,that
R9825	T12571	T12569	arg2Of	play,may
R9826	T12571	T12570	arg1Of	play,also
R9827	T12571	T12574	arg1Of	play,in
R9828	T12573	T12571	arg2Of	role,play
R9829	T12573	T12572	arg1Of	role,a
R9830	T12577	T12574	arg2Of	edema,in
R9831	T12577	T12575	arg1Of	edema,SE-induced
R9832	T12577	T12576	arg1Of	edema,vasogenic
R9833	T12581	T12580	arg1Of	findings,our
R9834	T12581	T12582	arg1Of	findings,indicate
R9835	T12582	T12578	arg1Of	indicate,Therefore
R9836	T12582	T12579	arg1Of	indicate,","
R9837	T12585	T12586	arg1Of	TNF-α,and
R9838	T12586	T12584	arg1Of	and,both
R9839	T12586	T12588	arg1Of	and,may
R9840	T12586	T12589	arg1Of	and,be
R9841	T12587	T12586	arg2Of	IL-1β,and
R9842	T12589	T12582	arg2Of	be,indicate
R9843	T12589	T12583	arg1Of	be,that
R9844	T12589	T12588	arg2Of	be,may
R9845	T12590	T12589	arg2Of	synergists,be
R9846	T12590	T12591	modOf	synergists,to
R9847	T12592	T12591	arg1Of	play,to
R9848	T12592	T12593	arg1Of	play,either
R9849	T12592	T12603	arg1Of	play,(
R9850	T12592	T12608	arg1Of	play,in
R9851	T12599	T12595	arg1Of	cells,direct
R9852	T12599	T12596	arg2Of	cells,(
R9853	T12599	T12597	arg1Of	cells,by
R9854	T12599	T12598	arg1Of	cells,endothelial
R9855	T12599	T12601	arg1Of	cells,or
R9856	T12600	T12596	arg3Of	),(
R9857	T12601	T12593	arg2Of	or,either
R9858	T12601	T12594	arg1Of	or,a
R9859	T12602	T12601	arg2Of	indirect,or
R9860	T12604	T12603	arg2Of	by,(
R9861	T12605	T12604	arg2Of	astrocytes,by
R9862	T12606	T12603	arg3Of	),(
R9863	T12607	T12592	arg2Of	role,play
R9864	T12610	T12608	arg2Of	maintenance,in
R9865	T12610	T12609	arg1Of	maintenance,the
R9866	T12610	T12611	arg1Of	maintenance,of
R9867	T12613	T12611	arg2Of	permeability,of
R9868	T12613	T12612	arg1Of	permeability,BBB
R9869	T12615	T12614	arg1Of	infiltration,Neutrophil
R9870	T12615	T12616	arg1Of	infiltration,into
R9871	T12615	T12619	arg1Of	infiltration,is
R9872	T12615	T12621	arg2Of	infiltration,observed
R9873	T12615	T12637	arg1Of	infiltration,disappears
R9874	T12618	T12616	arg2Of	parenchyma,into
R9875	T12618	T12617	arg1Of	parenchyma,brain
R9876	T12621	T12619	arg2Of	observed,is
R9877	T12621	T12620	arg1Of	observed,transiently
R9878	T12621	T12622	arg1Of	observed,during
R9879	T12621	T12636	arg1Of	observed,and
R9880	T12625	T12622	arg2Of	phase,during
R9881	T12625	T12623	arg1Of	phase,the
R9882	T12625	T12624	arg1Of	phase,acute
R9883	T12625	T12626	arg1Of	phase,of
R9884	T12627	T12626	arg2Of	SE,of
R9885	T12627	T12628	arg1Of	SE,(
R9886	T12629	T12628	arg2Of	4,(
R9887	T12629	T12633	arg1Of	4,after
R9888	T12632	T12630	arg1Of	hr,-
R9889	T12632	T12631	arg1Of	hr,36
R9890	T12633	T12632	arg1Of	after,hr
R9891	T12634	T12633	arg2Of	SE,after
R9892	T12635	T12628	arg3Of	),(
R9893	T12636	T12639	arg1Of	and,[
R9894	T12637	T12636	arg2Of	disappears,and
R9895	T12637	T12638	arg1Of	disappears,thereafter
R9896	T12640	T12639	arg2Of	20,[
R9897	T12641	T12639	arg3Of	],[
R9898	T12642	T12644	arg1Of	SE,increases
R9899	T12644	T12643	arg1Of	increases,rapidly
R9900	T12644	T12657	arg1Of	increases,[
R9901	T12645	T12646	arg1Of	synthesis,and
R9902	T12646	T12644	arg2Of	and,increases
R9903	T12646	T12648	arg1Of	and,of
R9904	T12646	T12650	arg1Of	and,in
R9905	T12647	T12646	arg2Of	release,and
R9906	T12649	T12648	arg2Of	chemokines,of
R9907	T12652	T12650	arg2Of	areas,in
R9908	T12652	T12651	arg1Of	areas,various
R9909	T12652	T12653	arg1Of	areas,of
R9910	T12656	T12653	arg2Of	brain,of
R9911	T12656	T12654	arg1Of	brain,the
R9912	T12656	T12655	arg1Of	brain,rodent
R9913	T12658	T12657	arg2Of	42,[
R9914	T12659	T12657	arg3Of	],[
R9915	T12661	T12660	arg2Of	them,Among
R9916	T12663	T12664	arg1Of	MIP-2,is
R9917	T12663	T12665	arg2Of	MIP-2,required
R9918	T12665	T12660	arg1Of	required,Among
R9919	T12665	T12662	arg1Of	required,","
R9920	T12665	T12664	arg2Of	required,is
R9921	T12665	T12666	arg1Of	required,for
R9922	T12668	T12669	arg1Of	neutrophil,or
R9923	T12670	T12669	arg2Of	lymphocyte,or
R9924	T12671	T12666	arg2Of	recruitment,for
R9925	T12671	T12667	arg1Of	recruitment,efficient
R9926	T12671	T12668	arg1Of	recruitment,neutrophil
R9927	T12671	T12670	arg1Of	recruitment,lymphocyte
R9928	T12671	T12672	arg1Of	recruitment,to
R9929	T12674	T12672	arg2Of	parenchyma,to
R9930	T12674	T12673	arg1Of	parenchyma,brain
R9931	T12674	T12675	arg1Of	parenchyma,[
R9932	T12676	T12675	arg2Of	43,[
R9933	T12677	T12675	arg3Of	],[
R9934	T12681	T12678	arg2Of	study,In
R9935	T12681	T12679	arg1Of	study,our
R9936	T12681	T12680	arg1Of	study,previous
R9937	T12681	T12682	arg1Of	study,[
R9938	T12683	T12682	arg2Of	20,[
R9939	T12684	T12682	arg3Of	],[
R9940	T12687	T12686	arg1Of	infiltration,neutrophil
R9941	T12687	T12688	arg1Of	infiltration,in
R9942	T12687	T12692	arg1Of	infiltration,was
R9943	T12687	T12693	arg2Of	infiltration,regulated
R9944	T12691	T12688	arg2Of	cortex,in
R9945	T12691	T12689	arg1Of	cortex,the
R9946	T12691	T12690	arg1Of	cortex,frontoparietal
R9947	T12693	T12678	arg1Of	regulated,In
R9948	T12693	T12685	arg1Of	regulated,","
R9949	T12693	T12692	arg2Of	regulated,was
R9950	T12698	T12693	arg1Of	expression,regulated
R9951	T12698	T12694	arg2Of	expression,by
R9952	T12698	T12695	arg1Of	expression,P2X7
R9953	T12698	T12696	arg1Of	expression,receptor-mediated
R9954	T12698	T12697	arg1Of	expression,MIP-2
R9955	T12701	T12699	arg2Of	PC,In
R9956	T12701	T12700	arg1Of	PC,the
R9957	T12709	T12707	arg1Of	agonist/antagonist,P2X7
R9958	T12709	T12708	arg1Of	agonist/antagonist,receptor
R9959	T12709	T12710	arg1Of	agonist/antagonist,nor
R9960	T12710	T12705	arg1Of	nor,neither
R9961	T12710	T12706	arg1Of	nor,a
R9962	T12710	T12718	arg1Of	nor,could
R9963	T12710	T12720	arg1Of	nor,affect
R9964	T12711	T12712	arg1Of	IL-1Ra,(
R9965	T12715	T12712	arg2Of	antagonist,(
R9966	T12715	T12713	arg1Of	antagonist,an
R9967	T12715	T12714	arg1Of	antagonist,IL-1β
R9968	T12716	T12712	arg3Of	),(
R9969	T12717	T12710	arg2Of	infusion,nor
R9970	T12717	T12711	arg1Of	infusion,IL-1Ra
R9971	T12720	T12699	arg1Of	affect,In
R9972	T12720	T12702	arg1Of	affect,","
R9973	T12720	T12703	arg1Of	affect,however
R9974	T12720	T12704	arg1Of	affect,","
R9975	T12720	T12718	arg2Of	affect,could
R9976	T12720	T12719	arg1Of	affect,not
R9977	T12722	T12720	arg2Of	infiltration,affect
R9978	T12722	T12721	arg1Of	infiltration,leukocyte
R9979	T12726	T12723	arg2Of	study,In
R9980	T12726	T12724	arg1Of	study,the
R9981	T12726	T12725	arg1Of	study,present
R9982	T12729	T12728	arg1Of	infusion,sTNFp55R
R9983	T12729	T12731	arg1Of	infusion,inhibited
R9984	T12729	T12738	arg1Of	infusion,reducing
R9985	T12731	T12723	arg1Of	inhibited,In
R9986	T12731	T12727	arg1Of	inhibited,","
R9987	T12731	T12730	arg1Of	inhibited,effectively
R9988	T12731	T12737	arg1Of	inhibited,by
R9989	T12733	T12731	arg2Of	infiltration,inhibited
R9990	T12733	T12732	arg1Of	infiltration,neutrophil
R9991	T12733	T12734	arg1Of	infiltration,in
R9992	T12736	T12734	arg2Of	PC,in
R9993	T12736	T12735	arg1Of	PC,the
R9994	T12738	T12737	arg2Of	reducing,by
R9995	T12738	T12742	arg1Of	reducing,in
R9996	T12741	T12738	arg2Of	formation,reducing
R9997	T12741	T12739	arg1Of	formation,vasogenic
R9998	T12741	T12740	arg1Of	formation,edema
R9999	T12745	T12742	arg2Of	manner,in
R10000	T12745	T12743	arg1Of	manner,a
R10001	T12745	T12744	arg1Of	manner,MIP-2-independent
R10002	T12746	T12748	arg1Of	With,to
R10003	T12747	T12746	arg2Of	respect,With
R10004	T12750	T12749	arg1Of	present,the
R10005	T12750	T12751	arg1Of	present,and
R10006	T12751	T12746	arg3Of	and,With
R10007	T12754	T12751	arg2Of	reports,and
R10008	T12754	T12752	arg1Of	reports,our
R10009	T12754	T12753	arg1Of	reports,previous
R10010	T12757	T12746	arg1Of	is,With
R10011	T12757	T12755	arg1Of	is,","
R10012	T12759	T12757	arg2Of	likely,is
R10013	T12759	T12758	arg1Of	likely,therefore
R10014	T12762	T12761	arg1Of	edema,vasogenic
R10015	T12762	T12763	arg2Of	edema,induced
R10016	T12762	T12766	arg1Of	edema,can
R10017	T12762	T12767	arg1Of	edema,induce
R10018	T12765	T12763	arg1Of	TNF-α,induced
R10019	T12765	T12764	arg2Of	TNF-α,by
R10020	T12767	T12756	arg1Of	induce,it
R10021	T12767	T12757	arg1Of	induce,is
R10022	T12767	T12759	arg1Of	induce,likely
R10023	T12767	T12760	arg1Of	induce,that
R10024	T12767	T12766	arg2Of	induce,can
R10025	T12767	T12773	modOf	induce,to
R10026	T12767	T12780	arg1Of	induce,","
R10027	T12767	T12781	arg1Of	induce,unlike
R10028	T12769	T12768	arg1Of	infiltration,neutrophil
R10029	T12769	T12770	arg1Of	infiltration,and
R10030	T12770	T12767	arg2Of	and,induce
R10031	T12772	T12770	arg2Of	injury,and
R10032	T12772	T12771	arg1Of	injury,press
R10033	T12774	T12773	arg1Of	evoke,to
R10034	T12776	T12774	arg2Of	loss,evoke
R10035	T12776	T12775	arg1Of	loss,neuronal-astroglial
R10036	T12776	T12777	arg1Of	loss,in
R10037	T12779	T12777	arg2Of	PC,in
R10038	T12779	T12778	arg1Of	PC,the
R10039	T12784	T12781	arg2Of	regions,unlike
R10040	T12784	T12782	arg1Of	regions,other
R10041	T12784	T12783	arg1Of	regions,brain
R10042	T12786	T12785	arg2Of	conclusion,In
R10043	T12789	T12788	arg1Of	findings,our
R10044	T12789	T12790	arg1Of	findings,reveal
R10045	T12790	T12785	arg1Of	reveal,In
R10046	T12790	T12787	arg1Of	reveal,","
R10047	T12792	T12793	arg1Of	impairments,of
R10048	T12792	T12797	arg1Of	impairments,via
R10049	T12792	T12804	arg1Of	impairments,may
R10050	T12792	T12805	arg1Of	impairments,be
R10051	T12792	T12806	arg2Of	impairments,involved
R10052	T12796	T12793	arg2Of	function,of
R10053	T12796	T12794	arg1Of	function,endothelial
R10054	T12796	T12795	arg1Of	function,cell
R10055	T12803	T12797	arg2Of	phosphorylation,via
R10056	T12803	T12798	arg1Of	phosphorylation,TNF-α
R10057	T12803	T12799	arg2Of	phosphorylation,mediated
R10058	T12803	T12800	arg1Of	phosphorylation,p65-Thr
R10059	T12803	T12801	arg1Of	phosphorylation,435
R10060	T12803	T12802	arg1Of	phosphorylation,NF-κB
R10061	T12806	T12790	arg2Of	involved,reveal
R10062	T12806	T12791	arg1Of	involved,that
R10063	T12806	T12804	arg2Of	involved,may
R10064	T12806	T12805	arg2Of	involved,be
R10065	T12806	T12807	arg1Of	involved,in
R10066	T12810	T12807	arg2Of	edema,in
R10067	T12810	T12808	arg1Of	edema,SE-induced
R10068	T12810	T12809	arg1Of	edema,vasogenic
R10069	T12810	T12811	arg1Of	edema,","
R10070	T12810	T12812	arg1Of	edema,which
R10071	T12810	T12813	arg1Of	edema,is
R10072	T12810	T12814	arg1Of	edema,relevant
R10073	T12814	T12813	arg2Of	relevant,is
R10074	T12814	T12815	arg1Of	relevant,to
R10075	T12817	T12816	arg1Of	infiltration,neutrophil
R10076	T12817	T12818	arg1Of	infiltration,and
R10077	T12818	T12815	arg2Of	and,to
R10078	T12820	T12818	arg2Of	loss,and
R10079	T12820	T12819	arg1Of	loss,neuronal-astroglial

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T11712	5409-5412	Protein	denotes	p65
T11711	5394-5399	Protein	denotes	TNF-α
T11710	5178-5183	Protein	denotes	TNF-α
T11709	5043-5048	Protein	denotes	MIP-2
T11708	4927-4934	Protein	denotes	TNFp55R
T11707	4836-4852	Protein	denotes	IL-1β antagonist
T11706	4825-4831	Protein	denotes	IL-1Ra
T11705	4740-4745	Protein	denotes	MIP-2
T11704	4717-4730	Protein	denotes	P2X7 receptor
T11703	4524-4529	Protein	denotes	MIP-2
T11702	4116-4121	Protein	denotes	IL-1β
T11701	4106-4111	Protein	denotes	TNF-α
T11700	3977-3980	Protein	denotes	p65
T11699	3962-3967	Protein	denotes	IL-1β
T11674	1659-1662	Protein	denotes	p65
T11673	1565-1568	Protein	denotes	p65
T11672	1492-1495	Protein	denotes	p65
T11671	1409-1414	Protein	denotes	TNF-α
T11670	1269-1275	Protein	denotes	TNFp55
T11669	1158-1163	Protein	denotes	TNF-α
T11668	1015-1020	Protein	denotes	TNF-α
T11667	860-866	Protein	denotes	TNFp55
T11666	840-845	Protein	denotes	TNF-α
T11665	805-812	Protein	denotes	TNFp75R
T11664	773-780	Protein	denotes	TNFp75R
T11663	761-768	Protein	denotes	TNFp55R
T11662	615-620	Protein	denotes	TNF-α
T11661	60-65	Protein	denotes	TNF-α
T11685	3443-3446	Protein	denotes	p65
T11684	3427-3430	Protein	denotes	p65
T11683	3415-3418	Protein	denotes	p65
T11682	3403-3406	Protein	denotes	p65
T11681	2971-2992	Protein	denotes	actin-binding protein
T11680	2956-2966	Protein	denotes	dystrophin
T11679	2731-2734	Protein	denotes	p65
T11678	2716-2721	Protein	denotes	TNF-α
T11677	2677-2682	Protein	denotes	TNF-α
T11676	2663-2666	Protein	denotes	p65
T11675	2550-2557	Protein	denotes	TNFp55R
T11698	3932-3937	Protein	denotes	IL-1β
T11697	3922-3927	Protein	denotes	TNF-α
T11696	3889-3892	Protein	denotes	p65
T11695	3874-3877	Protein	denotes	p65
T11694	3823-3826	Protein	denotes	p65
T11693	3808-3811	Protein	denotes	p65
T11692	3773-3780	Protein	denotes	TNFp55R
T11691	3732-3735	Protein	denotes	TNF
T11690	3686-3689	Protein	denotes	p65
T11689	3671-3674	Protein	denotes	p65
T11688	3579-3582	Protein	denotes	p65
T11687	3564-3567	Protein	denotes	p65
T11686	3525-3532	Protein	denotes	TNFp55R

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T12892	4825-4831	http://www.uniprot.org/uniprot/P18510	denotes	IL-1Ra
T12891	5043-5048	http://www.uniprot.org/uniprot/P10889	denotes	MIP-2
T12890	4740-4745	http://www.uniprot.org/uniprot/P10889	denotes	MIP-2
T12889	4524-4529	http://www.uniprot.org/uniprot/P10889	denotes	MIP-2
T12888	4836-4841	http://www.uniprot.org/uniprot/P01584	denotes	IL-1β
T12887	4116-4121	http://www.uniprot.org/uniprot/P01584	denotes	IL-1β
T12886	3962-3967	http://www.uniprot.org/uniprot/P01584	denotes	IL-1β
T12885	3932-3937	http://www.uniprot.org/uniprot/P01584	denotes	IL-1β
T12884	5409-5412	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12883	3977-3980	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12882	3889-3892	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12881	3874-3877	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12880	3823-3826	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12879	3808-3811	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12878	3686-3689	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12877	3671-3674	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12876	3579-3582	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12875	3564-3567	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12874	3443-3446	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12873	3427-3430	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12872	3415-3418	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12871	3403-3406	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12870	2731-2734	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12869	2663-2666	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12868	1659-1662	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12867	1565-1568	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12866	1492-1495	http://www.uniprot.org/uniprot/P21579	denotes	p65
T12865	5409-5412	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12864	3977-3980	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12863	3889-3892	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12862	3874-3877	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12861	3823-3826	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12860	3808-3811	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12859	3686-3689	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12858	3671-3674	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12857	3579-3582	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12856	3564-3567	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12855	3443-3446	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12854	3427-3430	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12853	3415-3418	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12852	3403-3406	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12851	2731-2734	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12850	2663-2666	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12849	1659-1662	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12848	1565-1568	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12847	1492-1495	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T12846	5394-5399	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12845	5178-5183	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12844	4106-4111	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12843	3922-3927	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12842	3732-3737	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12841	2716-2721	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12840	2677-2682	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12839	1409-1414	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12838	1158-1163	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12837	1015-1020	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12836	840-845	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12835	615-620	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12834	60-65	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T12833	5178-5181	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12832	4106-4109	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12831	3922-3925	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12830	3732-3735	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12829	2716-2719	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12828	2677-2680	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12827	1409-1412	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12826	1158-1161	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12825	1015-1018	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12824	840-843	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12823	698-701	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12822	615-618	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T12821	60-63	http://www.uniprot.org/uniprot/P01375	denotes	TNF

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T11624	4693-4699	http://purl.obolibrary.org/obo/UBERON_0001851	denotes	cortex
T11623	4602-4612	http://purl.obolibrary.org/obo/UBERON_0000353	denotes	parenchyma
T11622	4295-4305	http://purl.obolibrary.org/obo/UBERON_0000353	denotes	parenchyma
T11621	5294-5299	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T11620	4596-4601	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T11619	4500-4505	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T11618	4289-4294	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T11617	3038-3045	http://purl.obolibrary.org/obo/UBERON_0000055	denotes	vessels
T11616	2457-2464	http://purl.obolibrary.org/obo/UBERON_0000055	denotes	vessels
T11615	3032-3045	http://purl.obolibrary.org/obo/UBERON_0001981	denotes	blood vessels
T11614	2451-2464	http://purl.obolibrary.org/obo/UBERON_0001981	denotes	blood vessels
T11613	3032-3037	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T11612	2451-2456	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T11611	344-349	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T11737	4227-4245	http://purl.obolibrary.org/obo/GO_0035633	denotes	maintenance of BBB
T11736	2846-2857	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T11735	3178-3188	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T11734	2612-2622	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T11733	2327-2336	http://purl.obolibrary.org/obo/GO_0051179	denotes	localized
T11732	1534-1549	http://purl.obolibrary.org/obo/GO_2000144	denotes	transactivation
T11731	2099-2110	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T11730	1479-1490	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T11729	4433-4442	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T11728	1133-1142	http://purl.obolibrary.org/obo/GO_0009058	denotes	formation
T11727	200-209	http://purl.obolibrary.org/obo/GO_0009058	denotes	formation
T11726	5427-5442	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11725	3995-4010	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11724	3697-3712	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11723	3454-3469	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11722	2742-2757	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11721	2644-2659	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11720	1569-1584	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11719	1496-1511	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11718	120-135	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T11717	83-91	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T11716	1415-1424	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T11715	1164-1173	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T11714	846-855	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T11713	66-75	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T11745	2977-2992	http://purl.obolibrary.org/obo/GO_0005515	denotes	binding protein
T11744	2977-2984	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T11743	2971-2984	http://purl.obolibrary.org/obo/GO_0003779	denotes	actin-binding

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T11760	2352-2366	http://purl.obolibrary.org/obo/GO_0030054	denotes	cell junctions
T11759	2198-2221	http://purl.obolibrary.org/obo/GO_0005911	denotes	intercellular junctions
T11758	1623-1630	http://purl.obolibrary.org/obo/GO_0005634	denotes	nucleus
T11757	1606-1615	http://purl.obolibrary.org/obo/GO_0005737	denotes	cytoplasm
T11756	5376-5380	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T11755	4180-4185	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11754	3346-3351	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11753	2773-2778	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11752	2242-2247	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11751	1986-1991	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11750	1891-1896	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11749	1715-1720	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11748	798-803	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T11747	378-397	http://purl.obolibrary.org/obo/GO_0005615	denotes	extracellular space
T11746	378-391	http://purl.obolibrary.org/obo/GO_0005576	denotes	extracellular

sentences

Id	Subject	Object	Predicate	Lexical cue
T11660	5309-5564	Sentence	denotes	In conclusion, our findings reveal that impairments of endothelial cell function via TNF-α mediated p65-Thr 435 NF-κB phosphorylation may be involved in SE-induced vasogenic edema, which is relevant to neutrophil infiltration and neuronal-astroglial loss.
T11659	5069-5308	Sentence	denotes	With respect to the present and our previous reports, it is therefore likely that vasogenic edema induced by TNF-α can induce neutrophil infiltration and press injury to evoke neuronal-astroglial loss in the PC, unlike other brain regions.
T11658	4904-5068	Sentence	denotes	In the present study, sTNFp55R infusion effectively inhibited neutrophil infiltration in the PC by reducing vasogenic edema formation in a MIP-2-independent manner.
T11657	4758-4903	Sentence	denotes	In the PC, however, neither a P2X7 receptor agonist/antagonist nor IL-1Ra (an IL-1β antagonist) infusion could not affect leukocyte infiltration.
T11656	4619-4757	Sentence	denotes	In our previous study [20], neutrophil infiltration in the frontoparietal cortex was regulated by P2X7 receptor-mediated MIP-2 expression.
T11655	4512-4618	Sentence	denotes	Among them, MIP-2 is required for efficient neutrophil or lymphocyte recruitment to brain parenchyma [43].
T11654	4412-4511	Sentence	denotes	SE rapidly increases synthesis and release of chemokines in various areas of the rodent brain [42].
T11653	4260-4411	Sentence	denotes	Neutrophil infiltration into brain parenchyma is transiently observed during the acute phase of SE (4 - 36 hr after SE) and disappears thereafter [20].
T11652	4063-4259	Sentence	denotes	Therefore, our findings indicate that both TNF-α and IL-1β may be synergists to play either a direct (by endothelial cells) or indirect (by astrocytes) role in the maintenance of BBB permeability.
T11651	3868-4062	Sentence	denotes	Since p65-Ser529 and p65-Ser536 are phosphorylated by TNF-α and IL-1β [41], it is likely that IL-1β-mediated p65-Ser529/Ser536 phosphorylation may also play a role in SE-induced vasogenic edema.
T11650	3763-3867	Sentence	denotes	However, sTNFp55R infusion could not prevent p65-Ser529 and p65-Ser536 phosphorylations from SE insults.
T11649	3633-3762	Sentence	denotes	Therefore, it is likely that enhanced p65-Ser276 and p65-Ser311 phosphorylation may be involved in TNF-α-mediated BBB disruption.
T11648	3511-3632	Sentence	denotes	Furthermore, sTNFp55R infusion effectively inhibited p65-Ser276 and p65-Ser311phosphorylation in astrocytes following SE.
T11647	3381-3510	Sentence	denotes	In the present study, p65-Ser276, p65-Ser311, p65-Ser529, and p65-Ser536 phosphorylation was observed in astrocytes following SE.
T11646	3217-3380	Sentence	denotes	With respect to this previous report, changes in SMI immunoreactivity would be causes/results of interaction between endothelial cells and perivascular astrocytes.
T11645	2925-3216	Sentence	denotes	In our previous studies [5,8], dystrophin (an actin-binding protein [40]) immunoreactivity was detected in blood vessels and in astrocytic perivascular end-feet, and was down-regulated 12 hrs after SE prior to the appearance of vasogenic edema and down-regulation of SMI-71 immunoreactivity.
T11644	2624-2924	Sentence	denotes	With respect to the phosphorylation of p65-Thr435 by TNF-α [39], our findings indicate that TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells may play an important role in vasogenic edema induction via SMI-71 degradation or its posttranslational dysfunction influencing BBB permeability.
T11643	2536-2623	Sentence	denotes	Furthermore, sTNFp55R infusion effectively prevented SE-induced SMI-71 down-regulation.
T11642	2376-2535	Sentence	denotes	In the present study, SMI-71 immunoreactivity was significantly reduced in blood vessels 1 day after SE when vasogenic edema and neuronal damage were observed.
T11641	2136-2375	Sentence	denotes	Indeed, neutralization of SMI-71 in vivo leads to widening of intercellular junctions between endothelial cells and swelling of perivascular astrocytic processes [34], although SMI-71 is not localized at endothelial cell junctions [35-38].
T11640	2007-2135	Sentence	denotes	Acute phases of the above pathological conditions are accompanied by opening of the BBB and development of vasogenic edema [33].
T11639	1914-2006	Sentence	denotes	Under pathological conditions, SMI-71 expression is lost in endothelial cells [5,7,8,30,32].
T11638	1813-1913	Sentence	denotes	SMI-71, an endothelial barrier antigen, is a protein expressed by endothelial cells of rat BBB [31].
T11637	1637-1812	Sentence	denotes	In the present study, p65-Thr435 immunoreactivity was detected in endothelial cells, and its immunoreactivity showed an inverse correlation to the degree of SMI-71 expression.
T11636	1492-1636	Sentence	denotes	p65 phosphorylation of NF-κB enhances its transactivation potential, and p65 phosphorylation occurs in either the cytoplasm or the nucleus [30].
T11635	1372-1491	Sentence	denotes	Therefore, our findings suggest that TNF-α signaling may not be a unique upstream event in vasogenic edema development.
T11634	1246-1371	Sentence	denotes	In the present study, sTNFp55 infusion could not completely prevent SE-induced vasogenic edema and neuronal damage in the PC.
T11633	1150-1245	Sentence	denotes	Indeed, TNF-α signaling increases BBB permeability in various experimental disease models [29].
T11632	986-1149	Sentence	denotes	These findings indicate that TNF-α may participate in astroglial and endothelial responses to SE, which are relevant to SE-induced vasogenic edema formation [5-8].
T11631	815-985	Sentence	denotes	Furthermore, blockade of TNF-α signaling by sTNFp55 infusion effectively (but not completely) reduced volumes of SE-induced vasogenic edema and neuronal damage in the PC.
T11630	698-814	Sentence	denotes	TNF receptor expressions were also up-regulated in astrocytes (TNFp55R and TNFp75R) and endothelial cells (TNFp75R).
T11629	593-697	Sentence	denotes	In the present study, TNF-α immunoreactivity was obviously observed in microglia in the PC following SE.
T11628	471-592	Sentence	denotes	Furthermore, dysfunction of the BBB leads to epileptogenesis and contributes to progression of epilepsy [12,13,15,16,28].
T11627	333-470	Sentence	denotes	Leakage of serum-derived components into the extracellular space is associated with hyperexcitability and seizure onset [12,13,15,16,28].
T11626	247-332	Sentence	denotes	BBB disruption has been reported in experimental and human epilepsy [12,13,15,16,28].
T11625	11-246	Sentence	denotes	The major findings in the present study are that TNF-α signaling showed cellular specific responses of NF-κB phosphorylation in the PC following SE, which may be related to vasogenic edema formation followed by neutrophil infiltration.
T209	0-10	Sentence	denotes	Discussion
T210	11-246	Sentence	denotes	The major findings in the present study are that TNF-α signaling showed cellular specific responses of NF-κB phosphorylation in the PC following SE, which may be related to vasogenic edema formation followed by neutrophil infiltration.
T211	247-332	Sentence	denotes	BBB disruption has been reported in experimental and human epilepsy [12,13,15,16,28].
T212	333-470	Sentence	denotes	Leakage of serum-derived components into the extracellular space is associated with hyperexcitability and seizure onset [12,13,15,16,28].
T213	471-592	Sentence	denotes	Furthermore, dysfunction of the BBB leads to epileptogenesis and contributes to progression of epilepsy [12,13,15,16,28].
T214	593-697	Sentence	denotes	In the present study, TNF-α immunoreactivity was obviously observed in microglia in the PC following SE.
T215	698-814	Sentence	denotes	TNF receptor expressions were also up-regulated in astrocytes (TNFp55R and TNFp75R) and endothelial cells (TNFp75R).
T216	815-985	Sentence	denotes	Furthermore, blockade of TNF-α signaling by sTNFp55 infusion effectively (but not completely) reduced volumes of SE-induced vasogenic edema and neuronal damage in the PC.
T217	986-1149	Sentence	denotes	These findings indicate that TNF-α may participate in astroglial and endothelial responses to SE, which are relevant to SE-induced vasogenic edema formation [5-8].
T218	1150-1245	Sentence	denotes	Indeed, TNF-α signaling increases BBB permeability in various experimental disease models [29].
T219	1246-1371	Sentence	denotes	In the present study, sTNFp55 infusion could not completely prevent SE-induced vasogenic edema and neuronal damage in the PC.
T220	1372-1491	Sentence	denotes	Therefore, our findings suggest that TNF-α signaling may not be a unique upstream event in vasogenic edema development.
T221	1492-1636	Sentence	denotes	p65 phosphorylation of NF-κB enhances its transactivation potential, and p65 phosphorylation occurs in either the cytoplasm or the nucleus [30].
T222	1637-1812	Sentence	denotes	In the present study, p65-Thr435 immunoreactivity was detected in endothelial cells, and its immunoreactivity showed an inverse correlation to the degree of SMI-71 expression.
T223	1813-1913	Sentence	denotes	SMI-71, an endothelial barrier antigen, is a protein expressed by endothelial cells of rat BBB [31].
T224	1914-2006	Sentence	denotes	Under pathological conditions, SMI-71 expression is lost in endothelial cells [5,7,8,30,32].
T225	2007-2135	Sentence	denotes	Acute phases of the above pathological conditions are accompanied by opening of the BBB and development of vasogenic edema [33].
T226	2136-2375	Sentence	denotes	Indeed, neutralization of SMI-71 in vivo leads to widening of intercellular junctions between endothelial cells and swelling of perivascular astrocytic processes [34], although SMI-71 is not localized at endothelial cell junctions [35-38].
T227	2376-2535	Sentence	denotes	In the present study, SMI-71 immunoreactivity was significantly reduced in blood vessels 1 day after SE when vasogenic edema and neuronal damage were observed.
T228	2536-2623	Sentence	denotes	Furthermore, sTNFp55R infusion effectively prevented SE-induced SMI-71 down-regulation.
T229	2624-2924	Sentence	denotes	With respect to the phosphorylation of p65-Thr435 by TNF-α [39], our findings indicate that TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells may play an important role in vasogenic edema induction via SMI-71 degradation or its posttranslational dysfunction influencing BBB permeability.
T230	2925-3216	Sentence	denotes	In our previous studies [5,8], dystrophin (an actin-binding protein [40]) immunoreactivity was detected in blood vessels and in astrocytic perivascular end-feet, and was down-regulated 12 hrs after SE prior to the appearance of vasogenic edema and down-regulation of SMI-71 immunoreactivity.
T231	3217-3380	Sentence	denotes	With respect to this previous report, changes in SMI immunoreactivity would be causes/results of interaction between endothelial cells and perivascular astrocytes.
T232	3381-3510	Sentence	denotes	In the present study, p65-Ser276, p65-Ser311, p65-Ser529, and p65-Ser536 phosphorylation was observed in astrocytes following SE.
T233	3511-3632	Sentence	denotes	Furthermore, sTNFp55R infusion effectively inhibited p65-Ser276 and p65-Ser311phosphorylation in astrocytes following SE.
T234	3633-3762	Sentence	denotes	Therefore, it is likely that enhanced p65-Ser276 and p65-Ser311 phosphorylation may be involved in TNF-α-mediated BBB disruption.
T235	3763-3867	Sentence	denotes	However, sTNFp55R infusion could not prevent p65-Ser529 and p65-Ser536 phosphorylations from SE insults.
T236	3868-4062	Sentence	denotes	Since p65-Ser529 and p65-Ser536 are phosphorylated by TNF-α and IL-1β [41], it is likely that IL-1β-mediated p65-Ser529/Ser536 phosphorylation may also play a role in SE-induced vasogenic edema.
T237	4063-4259	Sentence	denotes	Therefore, our findings indicate that both TNF-α and IL-1β may be synergists to play either a direct (by endothelial cells) or indirect (by astrocytes) role in the maintenance of BBB permeability.
T238	4260-4411	Sentence	denotes	Neutrophil infiltration into brain parenchyma is transiently observed during the acute phase of SE (4 - 36 hr after SE) and disappears thereafter [20].
T239	4412-4511	Sentence	denotes	SE rapidly increases synthesis and release of chemokines in various areas of the rodent brain [42].
T240	4512-4618	Sentence	denotes	Among them, MIP-2 is required for efficient neutrophil or lymphocyte recruitment to brain parenchyma [43].
T241	4619-4757	Sentence	denotes	In our previous study [20], neutrophil infiltration in the frontoparietal cortex was regulated by P2X7 receptor-mediated MIP-2 expression.
T242	4758-4903	Sentence	denotes	In the PC, however, neither a P2X7 receptor agonist/antagonist nor IL-1Ra (an IL-1β antagonist) infusion could not affect leukocyte infiltration.
T243	4904-5068	Sentence	denotes	In the present study, sTNFp55R infusion effectively inhibited neutrophil infiltration in the PC by reducing vasogenic edema formation in a MIP-2-independent manner.
T244	5069-5308	Sentence	denotes	With respect to the present and our previous reports, it is therefore likely that vasogenic edema induced by TNF-α can induce neutrophil infiltration and press injury to evoke neuronal-astroglial loss in the PC, unlike other brain regions.
T245	5309-5564	Sentence	denotes	In conclusion, our findings reveal that impairments of endothelial cell function via TNF-α mediated p65-Thr 435 NF-κB phosphorylation may be involved in SE-induced vasogenic edema, which is relevant to neutrophil infiltration and neuronal-astroglial loss.

ICD10

Id	Subject	Object	Predicate	Lexical cue
T11742	5229-5235	http://purl.bioontology.org/ontology/ICD10/T14.9	denotes	injury
T11741	566-574	http://purl.bioontology.org/ontology/ICD10/G40	denotes	epilepsy
T11740	306-314	http://purl.bioontology.org/ontology/ICD10/G40	denotes	epilepsy
T11739	566-574	http://purl.bioontology.org/ontology/ICD10/G40.9	denotes	epilepsy
T11738	306-314	http://purl.bioontology.org/ontology/ICD10/G40.9	denotes	epilepsy

simple1

Id	Subject	Object	Predicate	Lexical cue
T11965	5409-5412	Protein	denotes	p65
T11964	5394-5399	Protein	denotes	TNF-α
T11963	5178-5183	Protein	denotes	TNF-α
T11962	5043-5048	Protein	denotes	MIP-2
T11961	4927-4934	Protein	denotes	TNFp55R
T11960	4836-4852	Protein	denotes	IL-1β antagonist
T11959	4825-4831	Protein	denotes	IL-1Ra
T11958	4740-4745	Protein	denotes	MIP-2
T11957	4717-4730	Protein	denotes	P2X7 receptor
T11956	4524-4529	Protein	denotes	MIP-2
T11955	4116-4121	Protein	denotes	IL-1β
T11954	4106-4111	Protein	denotes	TNF-α
T11953	3977-3980	Protein	denotes	p65
T11952	3962-3967	Protein	denotes	IL-1β
T11951	3932-3937	Protein	denotes	IL-1β
T11950	3922-3927	Protein	denotes	TNF-α
T11949	3889-3892	Protein	denotes	p65
T11948	3874-3877	Protein	denotes	p65
T11947	3823-3826	Protein	denotes	p65
T11946	3808-3811	Protein	denotes	p65
T11945	3773-3780	Protein	denotes	TNFp55R
T11944	3732-3735	Protein	denotes	TNF
T11943	3686-3689	Protein	denotes	p65
T11942	3671-3674	Protein	denotes	p65
T11941	3579-3582	Protein	denotes	p65
T11940	3564-3567	Protein	denotes	p65
T11939	3525-3532	Protein	denotes	TNFp55R
T11938	3443-3446	Protein	denotes	p65
T11937	3427-3430	Protein	denotes	p65
T11936	3415-3418	Protein	denotes	p65
T11935	3403-3406	Protein	denotes	p65
T11934	2971-2992	Protein	denotes	actin-binding protein
T11933	2956-2966	Protein	denotes	dystrophin
T11932	2731-2734	Protein	denotes	p65
T11931	2716-2721	Protein	denotes	TNF-α
T11930	2677-2682	Protein	denotes	TNF-α
T11929	2663-2666	Protein	denotes	p65
T11928	2550-2557	Protein	denotes	TNFp55R
T11927	1659-1662	Protein	denotes	p65
T11926	1565-1568	Protein	denotes	p65
T11925	1492-1495	Protein	denotes	p65
T11924	1409-1414	Protein	denotes	TNF-α
T11923	1269-1275	Protein	denotes	TNFp55
T11922	1158-1163	Protein	denotes	TNF-α
T11921	1015-1020	Protein	denotes	TNF-α
T11920	860-866	Protein	denotes	TNFp55
T11919	840-845	Protein	denotes	TNF-α
T11918	805-812	Protein	denotes	TNFp75R
T11917	773-780	Protein	denotes	TNFp75R
T11916	761-768	Protein	denotes	TNFp55R
T11915	615-620	Protein	denotes	TNF-α
T11914	60-65	Protein	denotes	TNF-α

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T14257	5427-5442	Phosphorylation	denotes	phosphorylation
T14256	4746-4756	Gene_expression	denotes	expression
T14255	4533-4541	Positive_regulation	denotes	required
T14254	3968-3976	Positive_regulation	denotes	mediated
T14253	3995-4010	Phosphorylation	denotes	phosphorylation
T14252	3904-3918	Phosphorylation	denotes	phosphorylated
T14251	3800-3807	Negative_regulation	denotes	prevent
T14250	3834-3850	Phosphorylation	denotes	phosphorylations
T14249	3736-3746	Positive_regulation	denotes	α-mediated
T14248	3697-3712	Phosphorylation	denotes	phosphorylation
T14247	3662-3670	Positive_regulation	denotes	enhanced
T14246	3583-3604	Phosphorylation	denotes	Ser311phosphorylation
T14245	3554-3563	Negative_regulation	denotes	inhibited
T14244	3407-3413	Negative_regulation	denotes	Ser276
T14243	3454-3469	Phosphorylation	denotes	phosphorylation
T14242	2722-2730	Positive_regulation	denotes	mediated
T14241	2742-2757	Phosphorylation	denotes	phosphorylation
T14240	2644-2659	Phosphorylation	denotes	phosphorylation
T14239	1569-1584	Phosphorylation	denotes	phosphorylation
T14238	1585-1591	Positive_regulation	denotes	occurs
T14237	1521-1529	Positive_regulation	denotes	enhances
T14236	1496-1511	Phosphorylation	denotes	phosphorylation
T14235	733-745	Positive_regulation	denotes	up-regulated
T14234	5409-5412	Protein	denotes	p65
T14233	5394-5399	Protein	denotes	TNF-α
T14232	5178-5183	Protein	denotes	TNF-α
T14231	5043-5048	Protein	denotes	MIP-2
T14230	4927-4934	Protein	denotes	TNFp55R
T14229	4836-4852	Protein	denotes	IL-1β antagonist
T14228	4825-4831	Protein	denotes	IL-1Ra
T14227	4740-4745	Protein	denotes	MIP-2
T14226	4717-4730	Protein	denotes	P2X7 receptor
T14225	4524-4529	Protein	denotes	MIP-2
T14224	4116-4121	Protein	denotes	IL-1β
T14223	4106-4111	Protein	denotes	TNF-α
T14222	3977-3980	Protein	denotes	p65
T14221	3962-3967	Protein	denotes	IL-1β
T14220	3932-3937	Protein	denotes	IL-1β
T14219	3922-3927	Protein	denotes	TNF-α
T14218	3889-3892	Protein	denotes	p65
T14217	3874-3877	Protein	denotes	p65
T14216	3823-3826	Protein	denotes	p65
T14215	3808-3811	Protein	denotes	p65
T14214	3773-3780	Protein	denotes	TNFp55R
T14213	3732-3735	Protein	denotes	TNF
T14212	3686-3689	Protein	denotes	p65
T14211	3671-3674	Protein	denotes	p65
T14210	3579-3582	Protein	denotes	p65
T14192	1269-1275	Protein	denotes	TNFp55
T14191	1158-1163	Protein	denotes	TNF-α
T14190	1015-1020	Protein	denotes	TNF-α
T14189	860-866	Protein	denotes	TNFp55
T14188	840-845	Protein	denotes	TNF-α
T14187	805-812	Protein	denotes	TNFp75R
T14186	773-780	Protein	denotes	TNFp75R
T14185	761-768	Protein	denotes	TNFp55R
T14184	615-620	Protein	denotes	TNF-α
T14183	60-65	Protein	denotes	TNF-α
T14209	3564-3567	Protein	denotes	p65
T14208	3525-3532	Protein	denotes	TNFp55R
T14207	3443-3446	Protein	denotes	p65
T14206	3427-3430	Protein	denotes	p65
T14205	3415-3418	Protein	denotes	p65
T14204	3403-3406	Protein	denotes	p65
T14203	2971-2992	Protein	denotes	actin-binding protein
T14202	2956-2966	Protein	denotes	dystrophin
T14201	2731-2734	Protein	denotes	p65
T14200	2716-2721	Protein	denotes	TNF-α
T14199	2677-2682	Protein	denotes	TNF-α
T14198	2663-2666	Protein	denotes	p65
T14197	2550-2557	Protein	denotes	TNFp55R
T14196	1659-1662	Protein	denotes	p65
T14195	1565-1568	Protein	denotes	p65
T14194	1492-1495	Protein	denotes	p65
T14193	1409-1414	Protein	denotes	TNF-α
R11153	T14194	T14236	themeOf	p65,phosphorylation
R11154	T14195	T14239	themeOf	p65,phosphorylation
R11157	T14198	T14240	themeOf	p65,phosphorylation
R11158	T14201	T14242	themeOf	p65,mediated
R11159	T14201	T14241	themeOf	p65,phosphorylation
R11160	T14204	T14244	themeOf	p65,Ser276
R11161	T14204	T14243	themeOf	p65,phosphorylation
R11162	T14205	T14243	themeOf	p65,phosphorylation
R11163	T14206	T14243	themeOf	p65,phosphorylation
R11164	T14207	T14243	themeOf	p65,phosphorylation
R11166	T14209	T14245	themeOf	p65,inhibited
R11167	T14210	T14246	themeOf	p65,Ser311phosphorylation
R11168	T14210	T14245	themeOf	p65,inhibited
R11169	T14211	T14248	themeOf	p65,phosphorylation
R11170	T14211	T14247	themeOf	p65,enhanced
R11171	T14212	T14248	themeOf	p65,phosphorylation
R11172	T14213	T14249	themeOf	TNF,α-mediated
R11190	T14236	T14237	themeOf	phosphorylation,enhances
R11191	T14239	T14238	themeOf	phosphorylation,occurs
R11193	T14248	T14247	themeOf	phosphorylation,enhanced
R11194	T14248	T14247	themeOf	phosphorylation,enhanced
R11145	T14185	T14235	themeOf	TNFp55R,up-regulated
R11146	T14186	T14235	themeOf	TNFp75R,up-regulated
R11173	T14215	T14251	themeOf	p65,prevent
R11174	T14216	T14250	themeOf	p65,phosphorylations
R11175	T14217	T14252	themeOf	p65,phosphorylated
R11177	T14218	T14252	themeOf	p65,phosphorylated
R11179	T14222	T14254	themeOf	p65,mediated
R11180	T14222	T14253	themeOf	p65,phosphorylation
R11182	T14225	T14255	themeOf	MIP-2,required
R11184	T14227	T14256	themeOf	MIP-2,expression
R11188	T14234	T14257	themeOf	p65,phosphorylation

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T13823	3932-3937	Protein	denotes	IL-1β
T13822	3922-3927	Protein	denotes	TNF-α
T13821	3889-3892	Protein	denotes	p65
T13820	3874-3877	Protein	denotes	p65
T13819	3823-3826	Protein	denotes	p65
T13818	3808-3811	Protein	denotes	p65
T13817	3773-3780	Protein	denotes	TNFp55R
T13816	3732-3735	Protein	denotes	TNF
T13815	3686-3689	Protein	denotes	p65
T13814	3671-3674	Protein	denotes	p65
T13860	5427-5442	Phosphorylation	denotes	phosphorylation
T13859	5400-5408	Positive_regulation	denotes	mediated
T13858	5167-5174	Positive_regulation	denotes	induced
T13857	5049-5060	Regulation	denotes	independent
T13856	4746-4756	Gene_expression	denotes	expression
T13855	4731-4739	Positive_regulation	denotes	mediated
T13854	4533-4541	Positive_regulation	denotes	required
T13853	3995-4010	Phosphorylation	denotes	phosphorylation
T13852	3968-3976	Positive_regulation	denotes	mediated
T13851	3904-3918	Phosphorylation	denotes	phosphorylated
T13850	3834-3850	Phosphorylation	denotes	phosphorylations
T13849	3736-3746	Positive_regulation	denotes	α-mediated
T13848	3697-3712	Phosphorylation	denotes	phosphorylation
T13847	3662-3670	Positive_regulation	denotes	enhanced
T13846	3583-3604	Phosphorylation	denotes	Ser311phosphorylation
T13845	3554-3563	Negative_regulation	denotes	inhibited
T13844	3454-3469	Phosphorylation	denotes	phosphorylation
T13843	2722-2730	Positive_regulation	denotes	mediated
T13842	2742-2757	Phosphorylation	denotes	phosphorylation
T13841	2644-2659	Phosphorylation	denotes	phosphorylation
T13840	1569-1584	Phosphorylation	denotes	phosphorylation
T13839	1496-1511	Phosphorylation	denotes	phosphorylation
T13838	733-745	Positive_regulation	denotes	up-regulated
T13837	5409-5412	Protein	denotes	p65
T13836	5394-5399	Protein	denotes	TNF-α
T13835	5178-5183	Protein	denotes	TNF-α
T13834	5043-5048	Protein	denotes	MIP-2
T13833	4927-4934	Protein	denotes	TNFp55R
T13832	4836-4852	Protein	denotes	IL-1β antagonist
T13831	4825-4831	Protein	denotes	IL-1Ra
T13830	4740-4745	Protein	denotes	MIP-2
T13829	4717-4730	Protein	denotes	P2X7 receptor
T13828	4524-4529	Protein	denotes	MIP-2
T13827	4116-4121	Protein	denotes	IL-1β
T13826	4106-4111	Protein	denotes	TNF-α
T13825	3977-3980	Protein	denotes	p65
T13824	3962-3967	Protein	denotes	IL-1β
T13786	60-65	Protein	denotes	TNF-α
T13788	761-768	Protein	denotes	TNFp55R
T13787	615-620	Protein	denotes	TNF-α
T13813	3579-3582	Protein	denotes	p65
T13812	3564-3567	Protein	denotes	p65
T13811	3525-3532	Protein	denotes	TNFp55R
T13810	3443-3446	Protein	denotes	p65
T13809	3427-3430	Protein	denotes	p65
T13808	3415-3418	Protein	denotes	p65
T13807	3403-3406	Protein	denotes	p65
T13806	2971-2992	Protein	denotes	actin-binding protein
T13805	2956-2966	Protein	denotes	dystrophin
T13804	2731-2734	Protein	denotes	p65
T13803	2716-2721	Protein	denotes	TNF-α
T13802	2677-2682	Protein	denotes	TNF-α
T13801	2663-2666	Protein	denotes	p65
T13800	2550-2557	Protein	denotes	TNFp55R
T13799	1659-1662	Protein	denotes	p65
T13798	1565-1568	Protein	denotes	p65
T13797	1492-1495	Protein	denotes	p65
T13796	1409-1414	Protein	denotes	TNF-α
T13795	1269-1275	Protein	denotes	TNFp55
T13794	1158-1163	Protein	denotes	TNF-α
T13793	1015-1020	Protein	denotes	TNF-α
T13792	860-866	Protein	denotes	TNFp55
T13791	840-845	Protein	denotes	TNF-α
T13790	805-812	Protein	denotes	TNFp75R
T13789	773-780	Protein	denotes	TNFp75R
R10973	T13797	T13839	themeOf	p65,phosphorylation
R10974	T13788	T13838	themeOf	TNFp55R,up-regulated
R10975	T13798	T13840	themeOf	p65,phosphorylation
R10976	T13802	T13841	themeOf	TNF-α,phosphorylation
R10977	T13803	T13843	causeOf	TNF-α,mediated
R10978	T13804	T13842	themeOf	p65,phosphorylation
R10979	T13807	T13844	themeOf	p65,phosphorylation
R10980	T13808	T13844	themeOf	p65,phosphorylation
R10981	T13809	T13844	themeOf	p65,phosphorylation
R10983	T13810	T13844	themeOf	p65,phosphorylation
R10985	T13812	T13845	themeOf	p65,inhibited
R10987	T13813	T13846	themeOf	p65,Ser311phosphorylation
R10988	T13813	T13845	themeOf	p65,inhibited
R10990	T13814	T13848	themeOf	p65,phosphorylation
R10992	T13814	T13847	themeOf	p65,enhanced
R10994	T13815	T13848	themeOf	p65,phosphorylation
R10998	T13816	T13849	themeOf	TNF,α-mediated
R11002	T13819	T13850	themeOf	p65,phosphorylations
R11006	T13820	T13851	themeOf	p65,phosphorylated
R11011	T13821	T13851	themeOf	p65,phosphorylated
R11013	T13822	T13851	themeOf	TNF-α,phosphorylated
R11014	T13823	T13851	themeOf	IL-1β,phosphorylated
R11017	T13824	T13852	causeOf	IL-1β,mediated
R11019	T13825	T13853	themeOf	p65,phosphorylation
R11021	T13828	T13854	themeOf	MIP-2,required
R11022	T13829	T13855	causeOf	P2X7 receptor,mediated
R11023	T13830	T13856	themeOf	MIP-2,expression
R11024	T13834	T13857	themeOf	MIP-2,independent
R11027	T13835	T13858	themeOf	TNF-α,induced
R11028	T13837	T13860	themeOf	p65,phosphorylation
R11030	T13842	T13843	themeOf	phosphorylation,mediated
R11038	T13848	T13847	themeOf	phosphorylation,enhanced
R11042	T13848	T13847	themeOf	phosphorylation,enhanced
R11043	T13853	T13852	themeOf	phosphorylation,mediated
R11044	T13856	T13855	themeOf	expression,mediated
R11045	T13860	T13859	themeOf	phosphorylation,mediated

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T13934	5400-5408	Positive_regulation	denotes	mediated
T13933	5427-5442	Phosphorylation	denotes	phosphorylation
T13932	4731-4739	Positive_regulation	denotes	mediated
T13931	4704-4713	Regulation	denotes	regulated
T13930	4746-4756	Gene_expression	denotes	expression
T13929	3968-3976	Positive_regulation	denotes	mediated
T13928	3995-4010	Phosphorylation	denotes	phosphorylation
T13927	3834-3850	Phosphorylation	denotes	phosphorylations
T13926	3662-3670	Positive_regulation	denotes	enhanced
T13925	3720-3728	Positive_regulation	denotes	involved
T13924	3697-3712	Phosphorylation	denotes	phosphorylation
T13923	3583-3604	Phosphorylation	denotes	Ser311phosphorylation
T13922	3554-3563	Negative_regulation	denotes	inhibited
T13921	3454-3469	Phosphorylation	denotes	phosphorylation
T13920	3095-3109	Negative_regulation	denotes	down-regulated
T13919	2722-2730	Positive_regulation	denotes	mediated
T13918	2742-2757	Phosphorylation	denotes	phosphorylation
T13917	2644-2659	Phosphorylation	denotes	phosphorylation
T13916	1569-1584	Phosphorylation	denotes	phosphorylation
T13915	1496-1511	Phosphorylation	denotes	phosphorylation
T13914	828-836	Negative_regulation	denotes	blockade
T13913	733-745	Positive_regulation	denotes	up-regulated
T13912	5409-5412	Protein	denotes	p65
T13911	5394-5399	Protein	denotes	TNF-α
T13910	5178-5183	Protein	denotes	TNF-α
T13909	5043-5048	Protein	denotes	MIP-2
T13908	4927-4934	Protein	denotes	TNFp55R
T13907	4836-4852	Protein	denotes	IL-1β antagonist
T13906	4825-4831	Protein	denotes	IL-1Ra
T13905	4740-4745	Protein	denotes	MIP-2
T13904	4717-4730	Protein	denotes	P2X7 receptor
T13903	4524-4529	Protein	denotes	MIP-2
T13902	4116-4121	Protein	denotes	IL-1β
T13901	4106-4111	Protein	denotes	TNF-α
T13900	3977-3980	Protein	denotes	p65
T13899	3962-3967	Protein	denotes	IL-1β
T13898	3932-3937	Protein	denotes	IL-1β
T13897	3922-3927	Protein	denotes	TNF-α
T13896	3889-3892	Protein	denotes	p65
T13895	3874-3877	Protein	denotes	p65
T13894	3823-3826	Protein	denotes	p65
T13893	3808-3811	Protein	denotes	p65
T13892	3773-3780	Protein	denotes	TNFp55R
T13891	3732-3735	Protein	denotes	TNF
T13890	3686-3689	Protein	denotes	p65
T13889	3671-3674	Protein	denotes	p65
T13888	3579-3582	Protein	denotes	p65
T13887	3564-3567	Protein	denotes	p65
T13886	3525-3532	Protein	denotes	TNFp55R
T13885	3443-3446	Protein	denotes	p65
T13884	3427-3430	Protein	denotes	p65
T13883	3415-3418	Protein	denotes	p65
T13882	3403-3406	Protein	denotes	p65
T13881	2971-2992	Protein	denotes	actin-binding protein
T13880	2956-2966	Protein	denotes	dystrophin
T13879	2731-2734	Protein	denotes	p65
T13878	2716-2721	Protein	denotes	TNF-α
T13877	2677-2682	Protein	denotes	TNF-α
T13876	2663-2666	Protein	denotes	p65
T13875	2550-2557	Protein	denotes	TNFp55R
T13874	1659-1662	Protein	denotes	p65
T13873	1565-1568	Protein	denotes	p65
T13872	1492-1495	Protein	denotes	p65
T13871	1409-1414	Protein	denotes	TNF-α
T13870	1269-1275	Protein	denotes	TNFp55
T13869	1158-1163	Protein	denotes	TNF-α
T13868	1015-1020	Protein	denotes	TNF-α
T13867	860-866	Protein	denotes	TNFp55
T13866	840-845	Protein	denotes	TNF-α
T13865	805-812	Protein	denotes	TNFp75R
T13864	773-780	Protein	denotes	TNFp75R
T13863	761-768	Protein	denotes	TNFp55R
T13862	615-620	Protein	denotes	TNF-α
T13861	60-65	Protein	denotes	TNF-α
R10982	T13863	T13913	themeOf	TNFp55R,up-regulated
R10984	T13864	T13913	themeOf	TNFp75R,up-regulated
R10986	T13866	T13914	themeOf	TNF-α,blockade
R10989	T13872	T13915	themeOf	p65,phosphorylation
R10991	T13873	T13916	themeOf	p65,phosphorylation
R10993	T13876	T13917	themeOf	p65,phosphorylation
R10995	T13877	T13917	themeOf	TNF-α,phosphorylation
R10996	T13878	T13919	causeOf	TNF-α,mediated
R10997	T13879	T13918	themeOf	p65,phosphorylation
R10999	T13880	T13920	themeOf	dystrophin,down-regulated
R11000	T13881	T13920	themeOf	actin-binding protein,down-regulated
R11001	T13882	T13921	themeOf	p65,phosphorylation
R11003	T13885	T13921	themeOf	p65,phosphorylation
R11004	T13887	T13922	themeOf	p65,inhibited
R11005	T13887	T13923	themeOf	p65,Ser311phosphorylation
R11007	T13888	T13923	themeOf	p65,Ser311phosphorylation
R11008	T13889	T13924	themeOf	p65,phosphorylation
R11009	T13890	T13924	themeOf	p65,phosphorylation
R11010	T13893	T13927	themeOf	p65,phosphorylations
R11012	T13894	T13927	themeOf	p65,phosphorylations
R11015	T13899	T13929	causeOf	IL-1β,mediated
R11016	T13900	T13928	themeOf	p65,phosphorylation
R11018	T13904	T13932	causeOf	P2X7 receptor,mediated
R11020	T13905	T13930	themeOf	MIP-2,expression
R11025	T13911	T13934	causeOf	TNF-α,mediated
R11026	T13912	T13933	themeOf	p65,phosphorylation
R11029	T13918	T13919	themeOf	phosphorylation,mediated
R11031	T13923	T13922	themeOf	Ser311phosphorylation,inhibited
R11032	T13923	T13922	themeOf	Ser311phosphorylation,inhibited
R11033	T13924	T13925	themeOf	phosphorylation,involved
R11034	T13924	T13926	themeOf	phosphorylation,enhanced
R11035	T13924	T13925	themeOf	phosphorylation,involved
R11036	T13924	T13926	themeOf	phosphorylation,enhanced
R11037	T13928	T13929	themeOf	phosphorylation,mediated
R11039	T13930	T13931	themeOf	expression,regulated
R11040	T13930	T13932	themeOf	expression,mediated
R11041	T13933	T13934	themeOf	phosphorylation,mediated

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T14337	805-812	Protein	denotes	TNFp75R
T14336	1602-1615	Entity	denotes	the cytoplasm
T14335	222-232	Entity	denotes	neutrophil
T14334	1703-1720	Entity	denotes	endothelial cells
T14333	4376-4378	Entity	denotes	SE
T14332	3823-3850	Entity	denotes	p65-Ser536 phosphorylations
T14331	3856-3858	Entity	denotes	SE
T14330	1974-2005	Entity	denotes	endothelial cells [5,7,8,30,32]
T14329	2549-2566	Entity	denotes	sTNFp55R infusion
T14328	1409-1414	Protein	denotes	TNF-α
T14327	1492-1495	Protein	denotes	p65
T14326	4927-4934	Entity	denotes	TNFp55R
T14325	928-938	Entity	denotes	SE-induced
T14324	3932-3943	Protein	denotes	IL-1β [41],
T14323	4260-4270	Entity	denotes	Neutrophil
T14322	4106-4111	Protein	denotes	TNF-α
T14321	3415-3418	Protein	denotes	p65
T14320	5394-5408	Protein	denotes	TNF-α mediated
T14319	4833-4852	Protein	denotes	an IL-1β antagonist
T14318	3922-3927	Protein	denotes	TNF-α
T14317	4717-4721	Protein	denotes	P2X7
T14316	4168-4185	Entity	denotes	endothelial cells
T14315	677-696	Protein	denotes	the PC following SE
T14314	1158-1163	Protein	denotes	TNF-α
T14313	4524-4529	Protein	denotes	MIP-2
T14312	856-875	Entity	denotes	by sTNFp55 infusion
T14311	4412-4414	Entity	denotes	SE
T14310	1856-1912	Protein	denotes	a protein expressed by endothelial cells of rat BBB [31]
T14309	3629-3631	Protein	denotes	SE
T14308	5364-5380	Entity	denotes	endothelial cell
T14307	3407-3413	Entity	denotes	Ser276
T14306	4203-4213	Entity	denotes	astrocytes
T14305	5421-5426	Protein	denotes	NF-κB
T14304	3524-3541	Entity	denotes	sTNFp55R infusion
T14303	664-696	Entity	denotes	microglia in the PC following SE
T14302	3889-3899	Entity	denotes	p65-Ser536
T14301	1268-1284	Entity	denotes	sTNFp55 infusion
T14300	2660-2673	Protein	denotes	of p65-Thr435
T14299	1080-1083	Entity	denotes	SE,
T14298	2477-2479	Entity	denotes	SE
T14297	1619-1635	Entity	denotes	the nucleus [30]
T14296	3732-3737	Protein	denotes	TNF-α
T14295	2968-2997	Protein	denotes	an actin-binding protein [40]
T14294	3419-3425	Entity	denotes	Ser311
T14293	2589-2599	Entity	denotes	SE-induced
T14292	1659-1669	Entity	denotes	p65-Thr435
T14291	2731-2741	Protein	denotes	p65-Thr435
T14290	1565-1568	Protein	denotes	p65
T14289	3808-3818	Entity	denotes	p65-Ser529
T14288	4458-4468	Protein	denotes	chemokines
T14287	840-845	Protein	denotes	TNF-α
T14286	5195-5205	Entity	denotes	neutrophil
T14285	4722-4739	Protein	denotes	receptor-mediated
T14284	2550-2553	Protein	denotes	TNF
T14283	4966-4976	Entity	denotes	neutrophil
T14282	4570-4580	Entity	denotes	lymphocyte
T14281	4116-4121	Protein	denotes	IL-1β
T14280	1364-1370	Protein	denotes	the PC
T14279	3095-3116	Protein	denotes	down-regulated 12 hrs
T14278	698-722	Protein	denotes	TNF receptor expressions
T14277	5511-5521	Entity	denotes	neutrophil
T14276	698-701	Protein	denotes	TNF
T14275	1512-1520	Protein	denotes	of NF-κB
T14274	4993-4999	Protein	denotes	the PC
T14273	156-158	Entity	denotes	SE
T14272	3962-3976	Protein	denotes	IL-1β-mediated
T14271	4353-4358	Protein	denotes	of SE
T14270	4740-4745	Protein	denotes	MIP-2
T14269	3334-3351	Entity	denotes	endothelial cells
T14268	2716-2730	Protein	denotes	TNF-α-mediated
T14267	3564-3574	Protein	denotes	p65-Ser276
T14266	1876-1912	Entity	denotes	by endothelial cells of rat BBB [31]
T14265	5394-5442	Protein	denotes	TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14264	4546-4566	Entity	denotes	efficient neutrophil
T14263	615-620	Protein	denotes	TNF-α
T14262	4647-4657	Entity	denotes	neutrophil
T14261	1106-1116	Entity	denotes	SE-induced
T14260	4935-4943	Entity	denotes	infusion
T14259	5394-5442	Entity	denotes	TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14258	374-397	Entity	denotes	the extracellular space
T14414	5394-5408	Regulation	denotes	TNF-α mediated
T14413	3686-3712	Phosphorylation	denotes	p65-Ser311 phosphorylation
T14412	1565-1584	Phosphorylation	denotes	p65 phosphorylation
T14411	4570-4617	Binding	denotes	lymphocyte recruitment to brain parenchyma [43]
T14410	1856-1912	Gene_expression	denotes	a protein expressed by endothelial cells of rat BBB [31]
T14409	1409-1424	Positive_regulation	denotes	TNF-α signaling
T14408	3095-3116	Negative_regulation	denotes	down-regulated 12 hrs
T14407	5003-5067	Negative_regulation	denotes	reducing vasogenic edema formation in a MIP-2-independent manner
T14406	2716-2778	Regulation	denotes	TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells
T14405	1158-1173	Positive_regulation	denotes	TNF-α signaling
T14404	4714-4756	Gene_expression	denotes	by P2X7 receptor-mediated MIP-2 expression
T14403	114-135	Phosphorylation	denotes	NF-κB phosphorylation
T14402	60-75	Positive_regulation	denotes	TNF-α signaling
T14401	4714-4756	Regulation	denotes	by P2X7 receptor-mediated MIP-2 expression
T14400	837-855	Positive_regulation	denotes	of TNF-α signaling
T14399	3662-3681	Positive_regulation	denotes	enhanced p65-Ser276
T14398	1492-1520	Phosphorylation	denotes	p65 phosphorylation of NF-κB
T14397	3443-3509	Phosphorylation	denotes	p65-Ser536 phosphorylation was observed in astrocytes following SE
T14396	5394-5442	Phosphorylation	denotes	TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14395	2640-2688	Phosphorylation	denotes	the phosphorylation of p65-Thr435 by TNF-α [39],
T14394	4802-4820	Entity	denotes	agonist/antagonist
T14393	4825-4862	Entity	denotes	IL-1Ra (an IL-1β antagonist) infusion
T14392	4880-4889	Entity	denotes	leukocyte
T14391	3427-3430	Protein	denotes	p65
T14390	3773-3776	Protein	denotes	TNF
T14389	1314-1324	Entity	denotes	SE-induced
T14388	2761-2778	Entity	denotes	endothelial cells
T14387	5273-5280	Protein	denotes	the PC,
T14386	1663-1669	Entity	denotes	Thr435
T14385	5462-5464	Entity	denotes	SE
T14384	3564-3574	Entity	denotes	p65-Ser276
T14383	3443-3453	Entity	denotes	p65-Ser536
T14382	3889-3899	Protein	denotes	p65-Ser536
T14381	786-813	Entity	denotes	endothelial cells (TNFp75R)
T14380	3686-3696	Protein	denotes	p65-Ser311
T14379	3356-3379	Entity	denotes	perivascular astrocytes
T14378	694-696	Protein	denotes	SE
T14377	3431-3437	Entity	denotes	Ser529
T14376	749-781	Entity	denotes	astrocytes (TNFp55R and TNFp75R)
T14375	139-145	Entity	denotes	the PC
T14374	114-119	Protein	denotes	NF-κB
T14373	3823-3850	Protein	denotes	p65-Ser536 phosphorylations
T14372	4129-4147	Entity	denotes	synergists to play
T14371	2660-2673	Entity	denotes	of p65-Thr435
T14370	2340-2356	Entity	denotes	endothelial cell
T14369	3686-3696	Entity	denotes	p65-Ser311
T14368	60-65	Protein	denotes	TNF-α
T14367	4927-4934	Protein	denotes	TNFp55R
T14366	2195-2247	Entity	denotes	of intercellular junctions between endothelial cells
T14365	2956-2998	Protein	denotes	dystrophin (an actin-binding protein [40])
T14364	3507-3509	Protein	denotes	SE
T14363	3808-3818	Protein	denotes	p65-Ser529
T14362	4825-4853	Protein	denotes	IL-1Ra (an IL-1β antagonist)
T14361	1659-1669	Protein	denotes	p65-Thr435
T14360	3662-3681	Protein	denotes	enhanced p65-Ser276
T14359	3874-3884	Protein	denotes	p65-Ser529
T14358	2230-2247	Entity	denotes	endothelial cells
T14357	4035-4045	Entity	denotes	SE-induced
T14356	3443-3453	Protein	denotes	p65-Ser536
T14355	3123-3125	Protein	denotes	SE
T14354	978-984	Protein	denotes	the PC
T14353	3772-3789	Entity	denotes	sTNFp55R infusion
T14352	2674-2687	Protein	denotes	by TNF-α [39]
T14351	3608-3618	Entity	denotes	astrocytes
T14350	1015-1020	Protein	denotes	TNF-α
T14349	3525-3528	Protein	denotes	TNF
T14348	4802-4820	Entity	denotes	agonist/antagonist
T14347	2731-2741	Entity	denotes	p65-Thr435
T14346	3403-3406	Protein	denotes	p65
T14345	3874-3884	Entity	denotes	p65-Ser529
T14344	3486-3509	Entity	denotes	astrocytes following SE
T14343	4761-4768	Protein	denotes	the PC,
T14342	1844-1852	Entity	denotes	antigen,
T14341	4810-4820	Entity	denotes	antagonist
T14340	3662-3681	Entity	denotes	enhanced p65-Ser276
T14339	5043-5060	Protein	denotes	MIP-2-independent
T14338	5175-5183	Protein	denotes	by TNF-α
R11186	T14259	T14305	partOf	TNF-α mediated p65-Thr 435 NF-κB phosphorylation,NF-κB
R11187	T14259	T14396	siteOf	TNF-α mediated p65-Thr 435 NF-κB phosphorylation,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11189	T14268	T14406	causeOf	TNF-α-mediated,TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells
R11192	T14270	T14404	themeOf	MIP-2,by P2X7 receptor-mediated MIP-2 expression
R11195	T14275	T14398	themeOf	of NF-κB,p65 phosphorylation of NF-κB
R11196	T14279	T14408	themeOf	down-regulated 12 hrs,down-regulated 12 hrs
R11197	T14285	T14401	causeOf	receptor-mediated,by P2X7 receptor-mediated MIP-2 expression
R11198	T14287	T14400	causeOf	TNF-α,of TNF-α signaling
R11199	T14290	T14412	themeOf	p65,p65 phosphorylation
R11200	T14380	T14413	themeOf	p65-Ser311,p65-Ser311 phosphorylation
R11201	T14383	T14356	partOf	p65-Ser536,p65-Ser536
R11202	T14383	T14397	siteOf	p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE
R11203	T14300	T14395	themeOf	of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11204	T14305	T14396	themeOf	NF-κB,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11205	T14310	T14410	themeOf	a protein expressed by endothelial cells of rat BBB [31],a protein expressed by endothelial cells of rat BBB [31]
R11206	T14404	T14401	themeOf	by P2X7 receptor-mediated MIP-2 expression,by P2X7 receptor-mediated MIP-2 expression
R11207	T14314	T14405	causeOf	TNF-α,TNF-α signaling
R11208	T14320	T14396	causeOf	TNF-α mediated,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11209	T14320	T14414	themeOf	TNF-α mediated,TNF-α mediated
R11210	T14327	T14398	causeOf	p65,p65 phosphorylation of NF-κB
R11211	T14328	T14409	causeOf	TNF-α,TNF-α signaling
R11212	T14352	T14395	causeOf	by TNF-α [39],"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11213	T14356	T14397	themeOf	p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE
R11214	T14360	T14399	themeOf	enhanced p65-Ser276,enhanced p65-Ser276
R11215	T14368	T14402	causeOf	TNF-α,TNF-α signaling
R11216	T14369	T14380	partOf	p65-Ser311,p65-Ser311
R11217	T14369	T14413	siteOf	p65-Ser311,p65-Ser311 phosphorylation
R11218	T14371	T14300	partOf	of p65-Thr435,of p65-Thr435
R11219	T14371	T14395	siteOf	of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11220	T14374	T14403	themeOf	NF-κB,NF-κB phosphorylation

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T13785	5563-5564	.	denotes	.
T13784	5559-5563	NN	denotes	loss
T13783	5539-5558	JJ	denotes	neuronal-astroglial
T13782	5535-5538	CC	denotes	and
T13781	5522-5534	NN	denotes	infiltration
T13780	5511-5521	NN	denotes	neutrophil
T13779	5508-5510	TO	denotes	to
T13778	5499-5507	JJ	denotes	relevant
T13777	5496-5498	VBZ	denotes	is
T13776	5490-5495	WDT	denotes	which
T13775	5488-5489	,	denotes	,
T13774	5483-5488	NN	denotes	edema
T13773	5473-5482	JJ	denotes	vasogenic
T13772	5462-5472	JJ	denotes	SE-induced
T13771	5459-5461	IN	denotes	in
T13770	5450-5458	VBN	denotes	involved
T13769	5447-5449	VB	denotes	be
T13768	5443-5446	MD	denotes	may
T13767	5427-5442	NN	denotes	phosphorylation
T13766	5421-5426	JJ	denotes	NF-κB
T13765	5417-5420	CD	denotes	435
T13764	5409-5416	JJ	denotes	p65-Thr
T13763	5400-5408	VBD	denotes	mediated
T13762	5394-5399	NNP	denotes	TNF-α
T13761	5390-5393	IN	denotes	via
T13760	5381-5389	NN	denotes	function
T13759	5376-5380	NN	denotes	cell
T13758	5364-5375	JJ	denotes	endothelial
T13757	5361-5363	IN	denotes	of
T13756	5349-5360	NNS	denotes	impairments
T13755	5344-5348	IN	denotes	that
T13754	5337-5343	VBP	denotes	reveal
T13753	5328-5336	NNS	denotes	findings
T13752	5324-5327	PRP$	denotes	our
T13751	5322-5323	,	denotes	,
T13750	5312-5322	NN	denotes	conclusion
T13749	5309-5311	IN	denotes	In
T13748	5307-5308	.	denotes	.
T13747	5300-5307	NNS	denotes	regions
T13746	5294-5299	NN	denotes	brain
T13745	5288-5293	JJ	denotes	other
T13744	5281-5287	IN	denotes	unlike
T13743	5279-5280	,	denotes	,
T13742	5277-5279	NN	denotes	PC
T13741	5273-5276	DT	denotes	the
T13740	5270-5272	IN	denotes	in
T13739	5265-5269	NN	denotes	loss
T13738	5245-5264	JJ	denotes	neuronal-astroglial
T13737	5239-5244	VB	denotes	evoke
T13736	5236-5238	TO	denotes	to
T13735	5229-5235	NN	denotes	injury
T13734	5223-5228	NN	denotes	press
T13733	5219-5222	CC	denotes	and
T13732	5206-5218	NN	denotes	infiltration
T13731	5195-5205	NN	denotes	neutrophil
T13730	5188-5194	VB	denotes	induce
T13729	5184-5187	MD	denotes	can
T13728	5178-5183	NNP	denotes	TNF-α
T13727	5175-5177	IN	denotes	by
T13726	5167-5174	VBN	denotes	induced
T13725	5161-5166	NN	denotes	edema
T13724	5151-5160	JJ	denotes	vasogenic
T13723	5146-5150	IN	denotes	that
T13722	5139-5145	JJ	denotes	likely
T13721	5129-5138	RB	denotes	therefore
T13720	5126-5128	VBZ	denotes	is
T13719	5123-5125	PRP	denotes	it
T13718	5121-5122	,	denotes	,
T13717	5114-5121	NNS	denotes	reports
T13716	5105-5113	JJ	denotes	previous
T13715	5101-5104	PRP$	denotes	our
T13714	5097-5100	CC	denotes	and
T13713	5089-5096	JJ	denotes	present
T13712	5085-5088	DT	denotes	the
T13711	5082-5084	TO	denotes	to
T13710	5074-5081	NN	denotes	respect
T13709	5069-5073	IN	denotes	With
T13708	5067-5068	.	denotes	.
T13707	5061-5067	NN	denotes	manner
T13706	5043-5060	JJ	denotes	MIP-2-independent
T13705	5041-5042	DT	denotes	a
T13704	5038-5040	IN	denotes	in
T13703	5028-5037	NN	denotes	formation
T13702	5022-5027	NN	denotes	edema
T13701	5012-5021	JJ	denotes	vasogenic
T13700	5003-5011	VBG	denotes	reducing
T13699	5000-5002	IN	denotes	by
T13698	4997-4999	NN	denotes	PC
T13697	4993-4996	DT	denotes	the
T13696	4990-4992	IN	denotes	in
T13695	4977-4989	NN	denotes	infiltration
T13694	4966-4976	NN	denotes	neutrophil
T13693	4956-4965	VBD	denotes	inhibited
T13692	4944-4955	RB	denotes	effectively
T13691	4935-4943	NN	denotes	infusion
T13690	4926-4934	JJ	denotes	sTNFp55R
T13689	4924-4925	,	denotes	,
T13688	4919-4924	NN	denotes	study
T13687	4911-4918	JJ	denotes	present
T13686	4907-4910	DT	denotes	the
T13685	4904-4906	IN	denotes	In
T13684	4902-4903	.	denotes	.
T13683	4890-4902	NN	denotes	infiltration
T13682	4880-4889	JJ	denotes	leukocyte
T13681	4873-4879	VB	denotes	affect
T13680	4869-4872	RB	denotes	not
T13679	4863-4868	MD	denotes	could
T13678	4854-4862	NN	denotes	infusion
T13677	4852-4853	-RRB-	denotes	)
T13676	4842-4852	NN	denotes	antagonist
T13675	4836-4841	NN	denotes	IL-1β
T13674	4833-4835	DT	denotes	an
T13673	4832-4833	-LRB-	denotes	(
T13672	4825-4831	JJ	denotes	IL-1Ra
T13671	4821-4824	CC	denotes	nor
T13670	4802-4820	JJ	denotes	agonist/antagonist
T13669	4793-4801	NN	denotes	receptor
T13668	4788-4792	NN	denotes	P2X7
T13667	4786-4787	DT	denotes	a
T13666	4778-4785	DT	denotes	neither
T13665	4776-4777	,	denotes	,
T13664	4769-4776	RB	denotes	however
T13663	4767-4768	,	denotes	,
T13662	4765-4767	NN	denotes	PC
T13661	4761-4764	DT	denotes	the
T13660	4758-4760	IN	denotes	In
T13659	4756-4757	.	denotes	.
T13658	4746-4756	NN	denotes	expression
T13657	4740-4745	NNP	denotes	MIP-2
T13656	4722-4739	VBD	denotes	receptor-mediated
T13655	4717-4721	NNP	denotes	P2X7
T13654	4714-4716	IN	denotes	by
T13653	4704-4713	VBN	denotes	regulated
T13652	4700-4703	VBD	denotes	was
T13651	4693-4699	NN	denotes	cortex
T13650	4678-4692	JJ	denotes	frontoparietal
T13649	4674-4677	DT	denotes	the
T13648	4671-4673	IN	denotes	in
T13647	4658-4670	NN	denotes	infiltration
T13646	4647-4657	NN	denotes	neutrophil
T13645	4645-4646	,	denotes	,
T13644	4644-4645	NNP	denotes	]
T13643	4642-4644	CD	denotes	20
T13642	4641-4642	NNP	denotes	[
T13641	4635-4640	NN	denotes	study
T13640	4626-4634	JJ	denotes	previous
T13639	4622-4625	PRP$	denotes	our
T13638	4619-4621	IN	denotes	In
T13637	4617-4618	.	denotes	.
T13636	4616-4617	NNP	denotes	]
T13635	4614-4616	CD	denotes	43
T13634	4613-4614	NNP	denotes	[
T13633	4602-4612	NN	denotes	parenchyma
T13632	4596-4601	NN	denotes	brain
T13631	4593-4595	TO	denotes	to
T13630	4581-4592	NN	denotes	recruitment
T13629	4570-4580	NN	denotes	lymphocyte
T13628	4567-4569	CC	denotes	or
T13627	4556-4566	NN	denotes	neutrophil
T13626	4546-4555	JJ	denotes	efficient
T13625	4542-4545	IN	denotes	for
T13624	4533-4541	VBN	denotes	required
T13623	4530-4532	VBZ	denotes	is
T13622	4524-4529	NNP	denotes	MIP-2
T13621	4522-4523	,	denotes	,
T13620	4518-4522	PRP	denotes	them
T13619	4512-4517	IN	denotes	Among
T13618	4510-4511	.	denotes	.
T13617	4509-4510	NNP	denotes	]
T13616	4507-4509	CD	denotes	42
T13615	4506-4507	NNP	denotes	[
T13614	4500-4505	NN	denotes	brain
T13613	4493-4499	NN	denotes	rodent
T13612	4489-4492	DT	denotes	the
T13611	4486-4488	IN	denotes	of
T13610	4480-4485	NNS	denotes	areas
T13609	4472-4479	JJ	denotes	various
T13608	4469-4471	IN	denotes	in
T13249	2177-2182	VBZ	denotes	leads
T13248	2172-2176	NN	denotes	vivo
T13247	2169-2171	IN	denotes	in
T13246	2162-2168	NN	denotes	SMI-71
T13245	2159-2161	IN	denotes	of
T13244	2144-2158	NN	denotes	neutralization
T13243	2142-2143	,	denotes	,
T13242	2136-2142	RB	denotes	Indeed
T13241	2134-2135	.	denotes	.
T13240	2133-2134	NNP	denotes	]
T13239	2131-2133	CD	denotes	33
T13238	2130-2131	NNP	denotes	[
T13237	2124-2129	NN	denotes	edema
T13236	2114-2123	JJ	denotes	vasogenic
T13235	2111-2113	IN	denotes	of
T13234	2099-2110	NN	denotes	development
T13233	2095-2098	CC	denotes	and
T13232	2091-2094	NNP	denotes	BBB
T13231	2087-2090	DT	denotes	the
T13230	2084-2086	IN	denotes	of
T13229	2076-2083	VBG	denotes	opening
T13228	2073-2075	IN	denotes	by
T13227	2061-2072	VBN	denotes	accompanied
T13226	2057-2060	VBP	denotes	are
T13225	2046-2056	NNS	denotes	conditions
T13224	2033-2045	JJ	denotes	pathological
T13223	2027-2032	JJ	denotes	above
T13222	2023-2026	DT	denotes	the
T13221	2020-2022	IN	denotes	of
T13220	2013-2019	NNS	denotes	phases
T13219	2007-2012	JJ	denotes	Acute
T13218	2005-2006	.	denotes	.
T13217	2004-2005	NNP	denotes	]
T13216	1993-2004	CD	denotes	5,7,8,30,32
T13215	1992-1993	NNP	denotes	[
T13214	1986-1991	NNS	denotes	cells
T13213	1974-1985	JJ	denotes	endothelial
T13212	1971-1973	IN	denotes	in
T13211	1966-1970	VBN	denotes	lost
T13210	1963-1965	VBZ	denotes	is
T13209	1952-1962	NN	denotes	expression
T13208	1945-1951	NNP	denotes	SMI-71
T13207	1943-1944	,	denotes	,
T13206	1933-1943	NNS	denotes	conditions
T13205	1920-1932	JJ	denotes	pathological
T13204	1914-1919	IN	denotes	Under
T13203	1912-1913	.	denotes	.
T13202	1911-1912	NNP	denotes	]
T13201	1909-1911	CD	denotes	31
T13200	1908-1909	NNP	denotes	[
T13199	1904-1907	NNP	denotes	BBB
T13198	1900-1903	NN	denotes	rat
T13197	1897-1899	IN	denotes	of
T13196	1891-1896	NNS	denotes	cells
T13195	1879-1890	JJ	denotes	endothelial
T13194	1876-1878	IN	denotes	by
T13193	1866-1875	VBN	denotes	expressed
T13192	1858-1865	NN	denotes	protein
T13191	1856-1857	DT	denotes	a
T13190	1853-1855	VBZ	denotes	is
T13189	1851-1852	,	denotes	,
T13188	1844-1851	NN	denotes	antigen
T13187	1836-1843	NN	denotes	barrier
T13186	1824-1835	JJ	denotes	endothelial
T13185	1821-1823	DT	denotes	an
T13184	1819-1820	,	denotes	,
T13183	1813-1819	CD	denotes	SMI-71
T13182	1811-1812	.	denotes	.
T13181	1801-1811	NN	denotes	expression
T13180	1794-1800	NNP	denotes	SMI-71
T13179	1791-1793	IN	denotes	of
T13178	1784-1790	NN	denotes	degree
T13177	1780-1783	DT	denotes	the
T13176	1777-1779	TO	denotes	to
T13175	1765-1776	NN	denotes	correlation
T13174	1757-1764	JJ	denotes	inverse
T13173	1754-1756	DT	denotes	an
T13172	1747-1753	VBD	denotes	showed
T13171	1730-1746	NN	denotes	immunoreactivity
T13170	1726-1729	PRP$	denotes	its
T13169	1722-1725	CC	denotes	and
T13168	1720-1721	,	denotes	,
T13167	1715-1720	NNS	denotes	cells
T13166	1703-1714	JJ	denotes	endothelial
T13165	1700-1702	IN	denotes	in
T13164	1691-1699	VBN	denotes	detected
T13163	1687-1690	VBD	denotes	was
T13162	1670-1686	NN	denotes	immunoreactivity
T13161	1659-1669	NN	denotes	p65-Thr435
T13160	1657-1658	,	denotes	,
T13159	1652-1657	NN	denotes	study
T13158	1644-1651	JJ	denotes	present
T13157	1640-1643	DT	denotes	the
T13156	1637-1639	IN	denotes	In
T13155	1635-1636	.	denotes	.
T13154	1634-1635	NNP	denotes	]
T13153	1632-1634	CD	denotes	30
T13152	1631-1632	NNP	denotes	[
T13151	1623-1630	NN	denotes	nucleus
T13150	1619-1622	DT	denotes	the
T13149	1616-1618	CC	denotes	or
T13148	1606-1615	NN	denotes	cytoplasm
T13147	1602-1605	DT	denotes	the
T13146	1595-1601	CC	denotes	either
T13145	1592-1594	IN	denotes	in
T13144	1585-1591	VBZ	denotes	occurs
T13143	1569-1584	NN	denotes	phosphorylation
T13142	1565-1568	CD	denotes	p65
T13141	1561-1564	CC	denotes	and
T13140	1559-1560	,	denotes	,
T13139	1550-1559	NN	denotes	potential
T13138	1534-1549	NN	denotes	transactivation
T13137	1530-1533	PRP$	denotes	its
T13136	1521-1529	VBZ	denotes	enhances
T13135	1515-1520	JJ	denotes	NF-κB
T13134	1512-1514	IN	denotes	of
T13133	1496-1511	NN	denotes	phosphorylation
T13132	1492-1495	NNS	denotes	p65
T13131	1490-1491	.	denotes	.
T13130	1479-1490	NN	denotes	development
T13129	1473-1478	NN	denotes	edema
T13128	1463-1472	JJ	denotes	vasogenic
T13127	1460-1462	IN	denotes	in
T13126	1454-1459	NN	denotes	event
T13125	1445-1453	JJ	denotes	upstream
T13124	1438-1444	JJ	denotes	unique
T13123	1436-1437	DT	denotes	a
T13122	1433-1435	VB	denotes	be
T13121	1429-1432	RB	denotes	not
T13120	1425-1428	MD	denotes	may
T13119	1415-1424	VBG	denotes	signaling
T13118	1409-1414	JJ	denotes	TNF-α
T13117	1404-1408	IN	denotes	that
T13116	1396-1403	VBP	denotes	suggest
T13115	1387-1395	NNS	denotes	findings
T13114	1383-1386	PRP$	denotes	our
T13113	1381-1382	,	denotes	,
T13112	1372-1381	RB	denotes	Therefore
T13111	1370-1371	.	denotes	.
T13110	1368-1370	NN	denotes	PC
T13109	1364-1367	DT	denotes	the
T13108	1361-1363	IN	denotes	in
T13107	1354-1360	NN	denotes	damage
T13106	1345-1353	JJ	denotes	neuronal
T13105	1341-1344	CC	denotes	and
T13104	1335-1340	NN	denotes	edema
T13103	1325-1334	JJ	denotes	vasogenic
T13102	1314-1324	JJ	denotes	SE-induced
T13101	1306-1313	VB	denotes	prevent
T13100	1295-1305	RB	denotes	completely
T13099	1291-1294	RB	denotes	not
T13098	1285-1290	MD	denotes	could
T13097	1276-1284	NN	denotes	infusion
T13096	1268-1275	JJ	denotes	sTNFp55
T13095	1266-1267	,	denotes	,
T13094	1261-1266	NN	denotes	study
T13093	1253-1260	JJ	denotes	present
T13092	1249-1252	DT	denotes	the
T13091	1246-1248	IN	denotes	In
T13090	1244-1245	.	denotes	.
T13089	1243-1244	NNP	denotes	]
T13088	1241-1243	CD	denotes	29
T13087	1240-1241	NNP	denotes	[
T13086	1233-1239	NNS	denotes	models
T13085	1225-1232	NN	denotes	disease
T13084	1212-1224	JJ	denotes	experimental
T13083	1204-1211	JJ	denotes	various
T13082	1201-1203	IN	denotes	in
T13081	1188-1200	NN	denotes	permeability
T13080	1184-1187	NNP	denotes	BBB
T13079	1174-1183	NNS	denotes	increases
T13078	1164-1173	VBG	denotes	signaling
T13077	1158-1163	JJ	denotes	TNF-α
T13076	1156-1157	,	denotes	,
T13075	1150-1156	RB	denotes	Indeed
T13074	1148-1149	.	denotes	.
T13073	1147-1148	NNP	denotes	]
T13072	1144-1147	CD	denotes	5-8
T13071	1143-1144	NNP	denotes	[
T13070	1133-1142	NN	denotes	formation
T13069	1127-1132	NN	denotes	edema
T13068	1117-1126	JJ	denotes	vasogenic
T13067	1106-1116	JJ	denotes	SE-induced
T13066	1103-1105	TO	denotes	to
T13065	1094-1102	JJ	denotes	relevant
T13064	1090-1093	VBP	denotes	are
T13063	1084-1089	WDT	denotes	which
T13062	1082-1083	,	denotes	,
T13061	1080-1082	NNP	denotes	SE
T13060	1077-1079	TO	denotes	to
T13059	1067-1076	NNS	denotes	responses
T13058	1055-1066	JJ	denotes	endothelial
T13057	1051-1054	CC	denotes	and
T13056	1040-1050	JJ	denotes	astroglial
T13055	1037-1039	IN	denotes	in
T13054	1025-1036	VB	denotes	participate
T13053	1021-1024	MD	denotes	may
T13052	1015-1020	NNP	denotes	TNF-α
T13051	1010-1014	IN	denotes	that
T13050	1001-1009	VBP	denotes	indicate
T13049	992-1000	NNS	denotes	findings
T13048	986-991	DT	denotes	These
T13047	984-985	.	denotes	.
T13046	982-984	NN	denotes	PC
T13045	978-981	DT	denotes	the
T13044	975-977	IN	denotes	in
T13043	968-974	NN	denotes	damage
T13042	959-967	JJ	denotes	neuronal
T13041	955-958	CC	denotes	and
T13040	949-954	NN	denotes	edema
T13039	939-948	JJ	denotes	vasogenic
T13038	928-938	JJ	denotes	SE-induced
T13037	925-927	IN	denotes	of
T13036	917-924	NNS	denotes	volumes
T13035	909-916	VBN	denotes	reduced
T13034	907-908	-RRB-	denotes	)
T13005	733-745	JJ	denotes	up-regulated
T13004	728-732	RB	denotes	also
T13003	723-727	VBD	denotes	were
T13002	711-722	NNS	denotes	expressions
T13001	702-710	NN	denotes	receptor
T13000	698-701	NN	denotes	TNF
T12999	696-697	.	denotes	.
T12998	694-696	NNP	denotes	SE
T12997	684-693	VBG	denotes	following
T12996	681-683	NN	denotes	PC
T12995	677-680	DT	denotes	the
T12994	674-676	IN	denotes	in
T12993	664-673	NN	denotes	microglia
T12992	661-663	IN	denotes	in
T12991	652-660	VBN	denotes	observed
T12990	642-651	RB	denotes	obviously
T12989	638-641	VBD	denotes	was
T12988	621-637	NN	denotes	immunoreactivity
T12987	615-620	JJ	denotes	TNF-α
T12986	613-614	,	denotes	,
T12985	608-613	NN	denotes	study
T12984	600-607	JJ	denotes	present
T12983	596-599	DT	denotes	the
T12982	593-595	IN	denotes	In
T12981	591-592	.	denotes	.
T12980	590-591	NNP	denotes	]
T12979	576-590	CD	denotes	12,13,15,16,28
T12978	575-576	NNP	denotes	[
T12977	566-574	NN	denotes	epilepsy
T12976	563-565	IN	denotes	of
T12975	551-562	NN	denotes	progression
T12974	548-550	TO	denotes	to
T12973	536-547	VBZ	denotes	contributes
T12972	532-535	CC	denotes	and
T12971	516-531	NN	denotes	epileptogenesis
T12970	513-515	TO	denotes	to
T12969	507-512	VBZ	denotes	leads
T12968	503-506	NNP	denotes	BBB
T12967	499-502	DT	denotes	the
T12966	496-498	IN	denotes	of
T12965	484-495	NN	denotes	dysfunction
T12964	482-483	,	denotes	,
T12963	471-482	RB	denotes	Furthermore
T12962	469-470	.	denotes	.
T12961	468-469	NNP	denotes	]
T12960	454-468	CD	denotes	12,13,15,16,28
T12959	453-454	NNP	denotes	[
T12958	447-452	NN	denotes	onset
T12957	439-446	NN	denotes	seizure
T12956	435-438	CC	denotes	and
T12955	417-434	NN	denotes	hyperexcitability
T12954	412-416	IN	denotes	with
T12953	401-411	VBN	denotes	associated
T12952	398-400	VBZ	denotes	is
T13607	4458-4468	NNS	denotes	chemokines
T13606	4455-4457	IN	denotes	of
T13605	4447-4454	NN	denotes	release
T13604	4443-4446	CC	denotes	and
T13603	4433-4442	NN	denotes	synthesis
T13602	4423-4432	VBZ	denotes	increases
T13601	4415-4422	RB	denotes	rapidly
T13600	4412-4414	RB	denotes	SE
T13599	4410-4411	.	denotes	.
T13598	4409-4410	NN	denotes	]
T13597	4407-4409	CD	denotes	20
T13596	4406-4407	JJ	denotes	[
T13595	4395-4405	RB	denotes	thereafter
T13594	4384-4394	VBZ	denotes	disappears
T13593	4380-4383	CC	denotes	and
T13592	4378-4379	-RRB-	denotes	)
T13591	4376-4378	NNP	denotes	SE
T13590	4370-4375	IN	denotes	after
T13589	4367-4369	NN	denotes	hr
T13588	4364-4366	CD	denotes	36
T13587	4362-4363	:	denotes	-
T13586	4360-4361	LS	denotes	4
T13585	4359-4360	-LRB-	denotes	(
T13584	4356-4358	NNP	denotes	SE
T13583	4353-4355	IN	denotes	of
T13582	4347-4352	NN	denotes	phase
T13581	4341-4346	JJ	denotes	acute
T13580	4337-4340	DT	denotes	the
T13579	4330-4336	IN	denotes	during
T13578	4321-4329	VBN	denotes	observed
T13577	4309-4320	RB	denotes	transiently
T13576	4306-4308	VBZ	denotes	is
T13575	4295-4305	NN	denotes	parenchyma
T13574	4289-4294	NN	denotes	brain
T13573	4284-4288	IN	denotes	into
T13572	4271-4283	NN	denotes	infiltration
T13571	4260-4270	NNP	denotes	Neutrophil
T13570	4258-4259	.	denotes	.
T13569	4246-4258	NN	denotes	permeability
T13568	4242-4245	NNP	denotes	BBB
T13567	4239-4241	IN	denotes	of
T13566	4227-4238	NN	denotes	maintenance
T13565	4223-4226	DT	denotes	the
T13564	4220-4222	IN	denotes	in
T13563	4215-4219	NN	denotes	role
T13562	4213-4214	-RRB-	denotes	)
T13561	4203-4213	NNS	denotes	astrocytes
T13560	4200-4202	IN	denotes	by
T13559	4199-4200	-LRB-	denotes	(
T13558	4190-4198	JJ	denotes	indirect
T13557	4187-4189	CC	denotes	or
T13556	4185-4186	-RRB-	denotes	)
T13555	4180-4185	NNS	denotes	cells
T13554	4168-4179	JJ	denotes	endothelial
T13553	4165-4167	IN	denotes	by
T13552	4164-4165	-LRB-	denotes	(
T13551	4157-4163	JJ	denotes	direct
T13550	4155-4156	DT	denotes	a
T13549	4148-4154	CC	denotes	either
T13548	4143-4147	VB	denotes	play
T13547	4140-4142	TO	denotes	to
T13546	4129-4139	NNS	denotes	synergists
T13545	4126-4128	VB	denotes	be
T13544	4122-4125	MD	denotes	may
T13543	4116-4121	NNP	denotes	IL-1β
T13542	4112-4115	CC	denotes	and
T13439	3415-3425	NN	denotes	p65-Ser311
T13438	3413-3414	,	denotes	,
T13437	3403-3413	NN	denotes	p65-Ser276
T13436	3401-3402	,	denotes	,
T13435	3396-3401	NN	denotes	study
T13434	3388-3395	JJ	denotes	present
T13433	3384-3387	DT	denotes	the
T13432	3381-3383	IN	denotes	In
T13431	3379-3380	.	denotes	.
T13430	3369-3379	NNS	denotes	astrocytes
T13429	3356-3368	JJ	denotes	perivascular
T13428	3352-3355	CC	denotes	and
T13427	3346-3351	NNS	denotes	cells
T13426	3334-3345	JJ	denotes	endothelial
T13425	3326-3333	IN	denotes	between
T13424	3314-3325	NN	denotes	interaction
T13423	3311-3313	IN	denotes	of
T13422	3296-3310	NNS	denotes	causes/results
T13421	3293-3295	VB	denotes	be
T13420	3287-3292	MD	denotes	would
T13419	3270-3286	NN	denotes	immunoreactivity
T13418	3266-3269	NNP	denotes	SMI
T13417	3263-3265	IN	denotes	in
T13416	3255-3262	NNS	denotes	changes
T13415	3253-3254	,	denotes	,
T13414	3247-3253	NN	denotes	report
T13413	3238-3246	JJ	denotes	previous
T13412	3233-3237	DT	denotes	this
T13411	3230-3232	TO	denotes	to
T13410	3222-3229	NN	denotes	respect
T13409	3217-3221	IN	denotes	With
T13408	3215-3216	.	denotes	.
T13407	3199-3215	NN	denotes	immunoreactivity
T13406	3192-3198	NNP	denotes	SMI-71
T13405	3189-3191	IN	denotes	of
T13404	3173-3188	NN	denotes	down-regulation
T13403	3169-3172	CC	denotes	and
T13402	3163-3168	NN	denotes	edema
T13401	3153-3162	JJ	denotes	vasogenic
T13400	3150-3152	IN	denotes	of
T13399	3139-3149	NN	denotes	appearance
T13398	3135-3138	DT	denotes	the
T13397	3132-3134	TO	denotes	to
T13396	3126-3131	RB	denotes	prior
T13395	3123-3125	NNP	denotes	SE
T13394	3117-3122	IN	denotes	after
T13393	3113-3116	NNS	denotes	hrs
T13392	3110-3112	CD	denotes	12
T13391	3095-3109	JJ	denotes	down-regulated
T13390	3091-3094	VBD	denotes	was
T13389	3087-3090	CC	denotes	and
T13388	3085-3086	,	denotes	,
T13387	3077-3085	NN	denotes	end-feet
T13386	3064-3076	JJ	denotes	perivascular
T13385	3053-3063	JJ	denotes	astrocytic
T13384	3050-3052	IN	denotes	in
T13383	3046-3049	CC	denotes	and
T13382	3038-3045	NNS	denotes	vessels
T13381	3032-3037	NN	denotes	blood
T13380	3029-3031	IN	denotes	in
T13379	3020-3028	VBN	denotes	detected
T13378	3016-3019	VBD	denotes	was
T13377	2999-3015	NN	denotes	immunoreactivity
T13376	2997-2998	-RRB-	denotes	)
T13375	2996-2997	NNP	denotes	]
T13374	2994-2996	CD	denotes	40
T13373	2993-2994	NNP	denotes	[
T13372	2985-2992	NN	denotes	protein
T13371	2971-2984	NN	denotes	actin-binding
T13370	2968-2970	DT	denotes	an
T13369	2967-2968	-LRB-	denotes	(
T13368	2956-2966	NN	denotes	dystrophin
T13367	2954-2955	,	denotes	,
T13366	2953-2954	NNP	denotes	]
T13365	2950-2953	CD	denotes	5,8
T13364	2949-2950	NNP	denotes	[
T13363	2941-2948	NNS	denotes	studies
T13362	2932-2940	JJ	denotes	previous
T13361	2928-2931	PRP$	denotes	our
T13360	2925-2927	IN	denotes	In
T13359	2923-2924	.	denotes	.
T13358	2911-2923	NN	denotes	permeability
T13357	2907-2910	NNP	denotes	BBB
T13356	2895-2906	VBG	denotes	influencing
T13355	2883-2894	NN	denotes	dysfunction
T13354	2865-2882	JJ	denotes	posttranslational
T13353	2861-2864	PRP$	denotes	its
T13352	2858-2860	CC	denotes	or
T13351	2846-2857	NN	denotes	degradation
T13350	2839-2845	NNP	denotes	SMI-71
T13349	2835-2838	IN	denotes	via
T13348	2825-2834	NN	denotes	induction
T13347	2819-2824	NN	denotes	edema
T13346	2809-2818	JJ	denotes	vasogenic
T13345	2806-2808	IN	denotes	in
T13344	2801-2805	NN	denotes	role
T13343	2791-2800	JJ	denotes	important
T13342	2788-2790	DT	denotes	an
T13341	2783-2787	VB	denotes	play
T13340	2779-2782	MD	denotes	may
T13339	2773-2778	NNS	denotes	cells
T13338	2761-2772	JJ	denotes	endothelial
T13337	2758-2760	IN	denotes	in
T13336	2742-2757	NN	denotes	phosphorylation
T13335	2731-2741	NN	denotes	p65-Thr435
T13334	2716-2730	JJ	denotes	TNF-α-mediated
T13333	2711-2715	IN	denotes	that
T13332	2702-2710	VBP	denotes	indicate
T13331	2693-2701	NNS	denotes	findings
T13330	2689-2692	PRP$	denotes	our
T13329	2687-2688	,	denotes	,
T13328	2686-2687	NNP	denotes	]
T13327	2684-2686	CD	denotes	39
T13326	2683-2684	NNP	denotes	[
T13325	2677-2682	NNP	denotes	TNF-α
T13324	2674-2676	IN	denotes	by
T13323	2663-2673	NN	denotes	p65-Thr435
T13322	2660-2662	IN	denotes	of
T13321	2644-2659	NN	denotes	phosphorylation
T13320	2640-2643	DT	denotes	the
T13319	2637-2639	TO	denotes	to
T13318	2629-2636	NN	denotes	respect
T13317	2624-2628	IN	denotes	With
T13316	2622-2623	.	denotes	.
T13315	2607-2622	NN	denotes	down-regulation
T13314	2600-2606	NNP	denotes	SMI-71
T13313	2589-2599	JJ	denotes	SE-induced
T13312	2579-2588	VBD	denotes	prevented
T13311	2567-2578	RB	denotes	effectively
T13310	2558-2566	NN	denotes	infusion
T13309	2549-2557	JJ	denotes	sTNFp55R
T13308	2547-2548	,	denotes	,
T13307	2536-2547	RB	denotes	Furthermore
T13306	2534-2535	.	denotes	.
T13305	2526-2534	VBN	denotes	observed
T13304	2521-2525	VBD	denotes	were
T13303	2514-2520	NN	denotes	damage
T13302	2505-2513	JJ	denotes	neuronal
T13301	2501-2504	CC	denotes	and
T13300	2495-2500	NN	denotes	edema
T13299	2485-2494	JJ	denotes	vasogenic
T13298	2480-2484	WRB	denotes	when
T13297	2477-2479	NNP	denotes	SE
T13296	2471-2476	IN	denotes	after
T13295	2467-2470	NN	denotes	day
T13294	2465-2466	CD	denotes	1
T13293	2457-2464	NNS	denotes	vessels
T13292	2451-2456	NN	denotes	blood
T13291	2448-2450	IN	denotes	in
T13290	2440-2447	VBN	denotes	reduced
T13289	2426-2439	RB	denotes	significantly
T13288	2422-2425	VBD	denotes	was
T13287	2405-2421	NN	denotes	immunoreactivity
T13286	2398-2404	NNP	denotes	SMI-71
T13285	2396-2397	,	denotes	,
T13284	2391-2396	NN	denotes	study
T13283	2383-2390	JJ	denotes	present
T13282	2379-2382	DT	denotes	the
T13281	2376-2378	IN	denotes	In
T13280	2374-2375	.	denotes	.
T13279	2373-2374	NNP	denotes	]
T13278	2368-2373	CD	denotes	35-38
T13277	2367-2368	NNP	denotes	[
T13276	2357-2366	NNS	denotes	junctions
T13275	2352-2356	NN	denotes	cell
T13274	2340-2351	JJ	denotes	endothelial
T13273	2337-2339	IN	denotes	at
T13272	2327-2336	VBN	denotes	localized
T13271	2323-2326	RB	denotes	not
T13270	2320-2322	VBZ	denotes	is
T13269	2313-2319	NNP	denotes	SMI-71
T13268	2304-2312	IN	denotes	although
T13267	2302-2303	,	denotes	,
T13266	2301-2302	NNP	denotes	]
T13265	2299-2301	CD	denotes	34
T13264	2298-2299	NNP	denotes	[
T13263	2288-2297	NNS	denotes	processes
T13262	2277-2287	JJ	denotes	astrocytic
T13261	2264-2276	JJ	denotes	perivascular
T13260	2261-2263	IN	denotes	of
T13259	2252-2260	VBG	denotes	swelling
T13258	2248-2251	CC	denotes	and
T13257	2242-2247	NNS	denotes	cells
T13256	2230-2241	JJ	denotes	endothelial
T13255	2222-2229	IN	denotes	between
T13254	2212-2221	NNS	denotes	junctions
T13253	2198-2211	JJ	denotes	intercellular
T13252	2195-2197	IN	denotes	of
T13251	2186-2194	VBG	denotes	widening
T13250	2183-2185	TO	denotes	to
T12951	392-397	NN	denotes	space
T12950	378-391	JJ	denotes	extracellular
T12949	374-377	DT	denotes	the
T12948	369-373	IN	denotes	into
T12947	358-368	NNS	denotes	components
T12946	344-357	JJ	denotes	serum-derived
T12945	341-343	IN	denotes	of
T12944	333-340	NNP	denotes	Leakage
T12943	331-332	.	denotes	.
T12942	330-331	NNP	denotes	]
T12941	316-330	CD	denotes	12,13,15,16,28
T12940	315-316	NNP	denotes	[
T12939	306-314	NN	denotes	epilepsy
T12938	300-305	JJ	denotes	human
T12937	296-299	CC	denotes	and
T12936	283-295	JJ	denotes	experimental
T12935	280-282	IN	denotes	in
T12934	271-279	VBN	denotes	reported
T12933	266-270	VBN	denotes	been
T12932	262-265	VBZ	denotes	has
T12931	251-261	NN	denotes	disruption
T12930	247-250	NNP	denotes	BBB
T12929	245-246	.	denotes	.
T12928	233-245	NN	denotes	infiltration
T12927	222-232	NN	denotes	neutrophil
T12926	219-221	IN	denotes	by
T12925	210-218	VBN	denotes	followed
T12924	200-209	NN	denotes	formation
T12923	194-199	NN	denotes	edema
T12922	184-193	JJ	denotes	vasogenic
T12921	181-183	TO	denotes	to
T12920	173-180	VBN	denotes	related
T12919	170-172	VB	denotes	be
T12918	166-169	MD	denotes	may
T12917	160-165	WDT	denotes	which
T12916	158-159	,	denotes	,
T12915	156-158	NNP	denotes	SE
T12914	146-155	VBG	denotes	following
T12913	143-145	NN	denotes	PC
T12912	139-142	DT	denotes	the
T12911	136-138	IN	denotes	in
T12910	120-135	NN	denotes	phosphorylation
T12909	114-119	JJ	denotes	NF-κB
T12908	111-113	IN	denotes	of
T12907	101-110	NNS	denotes	responses
T12906	92-100	JJ	denotes	specific
T12905	83-91	JJ	denotes	cellular
T12904	76-82	VBD	denotes	showed
T12903	66-75	VBG	denotes	signaling
T12902	60-65	JJ	denotes	TNF-α
T12901	55-59	IN	denotes	that
T12900	51-54	VBP	denotes	are
T12899	45-50	NN	denotes	study
T12898	37-44	JJ	denotes	present
T12897	33-36	DT	denotes	the
T12896	30-32	IN	denotes	in
T12895	21-29	NNS	denotes	findings
T12894	15-20	JJ	denotes	major
T12893	11-14	DT	denotes	The
T13541	4106-4111	NNP	denotes	TNF-α
T13540	4101-4105	DT	denotes	both
T13539	4096-4100	IN	denotes	that
T13538	4087-4095	VBP	denotes	indicate
T13537	4078-4086	NNS	denotes	findings
T13536	4074-4077	PRP$	denotes	our
T13535	4072-4073	,	denotes	,
T13534	4063-4072	RB	denotes	Therefore
T13533	4061-4062	.	denotes	.
T13532	4056-4061	NN	denotes	edema
T13531	4046-4055	JJ	denotes	vasogenic
T13530	4035-4045	JJ	denotes	SE-induced
T13529	4032-4034	IN	denotes	in
T13528	4027-4031	NN	denotes	role
T13527	4025-4026	DT	denotes	a
T13526	4020-4024	VB	denotes	play
T13525	4015-4019	RB	denotes	also
T13524	4011-4014	MD	denotes	may
T13523	3995-4010	NN	denotes	phosphorylation
T13522	3988-3994	NNP	denotes	Ser536
T13521	3987-3988	NN	denotes	/
T13520	3977-3987	JJ	denotes	p65-Ser529
T13519	3962-3976	JJ	denotes	IL-1β-mediated
T13518	3957-3961	IN	denotes	that
T13517	3950-3956	JJ	denotes	likely
T13516	3947-3949	VBZ	denotes	is
T13515	3944-3946	PRP	denotes	it
T13514	3942-3943	,	denotes	,
T13513	3941-3942	NNP	denotes	]
T13512	3939-3941	CD	denotes	41
T13511	3938-3939	NNP	denotes	[
T13510	3932-3937	NNP	denotes	IL-1β
T13509	3928-3931	CC	denotes	and
T13508	3922-3927	NNP	denotes	TNF-α
T13507	3919-3921	IN	denotes	by
T13506	3904-3918	VBN	denotes	phosphorylated
T13505	3900-3903	VBP	denotes	are
T13504	3889-3899	NN	denotes	p65-Ser536
T13503	3885-3888	CC	denotes	and
T13502	3874-3884	NN	denotes	p65-Ser529
T13501	3868-3873	IN	denotes	Since
T13500	3866-3867	.	denotes	.
T13499	3859-3866	NNS	denotes	insults
T13498	3856-3858	JJ	denotes	SE
T13497	3851-3855	IN	denotes	from
T13496	3834-3850	NNS	denotes	phosphorylations
T13495	3823-3833	NN	denotes	p65-Ser536
T13494	3819-3822	CC	denotes	and
T13493	3808-3818	NN	denotes	p65-Ser529
T13492	3800-3807	VB	denotes	prevent
T13491	3796-3799	RB	denotes	not
T13490	3790-3795	MD	denotes	could
T13489	3781-3789	NN	denotes	infusion
T13488	3772-3780	JJ	denotes	sTNFp55R
T13487	3770-3771	,	denotes	,
T13486	3763-3770	RB	denotes	However
T13485	3761-3762	.	denotes	.
T13484	3751-3761	NN	denotes	disruption
T13483	3747-3750	NNP	denotes	BBB
T13482	3732-3746	JJ	denotes	TNF-α-mediated
T13481	3729-3731	IN	denotes	in
T13480	3720-3728	VBN	denotes	involved
T13479	3717-3719	VB	denotes	be
T13478	3713-3716	MD	denotes	may
T13477	3697-3712	NN	denotes	phosphorylation
T13476	3686-3696	NN	denotes	p65-Ser311
T13475	3682-3685	CC	denotes	and
T13474	3671-3681	NN	denotes	p65-Ser276
T13473	3662-3670	JJ	denotes	enhanced
T13472	3657-3661	IN	denotes	that
T13471	3650-3656	JJ	denotes	likely
T13470	3647-3649	VBZ	denotes	is
T13469	3644-3646	PRP	denotes	it
T13468	3642-3643	,	denotes	,
T13467	3633-3642	RB	denotes	Therefore
T13466	3631-3632	.	denotes	.
T13465	3629-3631	NNP	denotes	SE
T13464	3619-3628	VBG	denotes	following
T13463	3608-3618	NNS	denotes	astrocytes
T13462	3605-3607	IN	denotes	in
T13461	3579-3604	NN	denotes	p65-Ser311phosphorylation
T13460	3575-3578	CC	denotes	and
T13459	3564-3574	NN	denotes	p65-Ser276
T13458	3554-3563	VBD	denotes	inhibited
T13457	3542-3553	RB	denotes	effectively
T13456	3533-3541	NN	denotes	infusion
T13455	3524-3532	JJ	denotes	sTNFp55R
T13454	3522-3523	,	denotes	,
T13453	3511-3522	RB	denotes	Furthermore
T13452	3509-3510	.	denotes	.
T13451	3507-3509	NNP	denotes	SE
T13450	3497-3506	VBG	denotes	following
T13449	3486-3496	NNS	denotes	astrocytes
T13448	3483-3485	IN	denotes	in
T13447	3474-3482	VBN	denotes	observed
T13446	3470-3473	VBD	denotes	was
T13445	3454-3469	NN	denotes	phosphorylation
T13444	3443-3453	NNP	denotes	p65-Ser536
T13443	3439-3442	CC	denotes	and
T13442	3437-3438	,	denotes	,
T13441	3427-3437	NN	denotes	p65-Ser529
T13440	3425-3426	,	denotes	,
T13033	897-907	RB	denotes	completely
T13032	893-896	RB	denotes	not
T13031	889-892	CC	denotes	but
T13030	888-889	-LRB-	denotes	(
T13029	876-887	RB	denotes	effectively
T13028	867-875	NN	denotes	infusion
T13027	859-866	NNS	denotes	sTNFp55
T13026	856-858	IN	denotes	by
T13025	846-855	VBG	denotes	signaling
T13024	840-845	JJ	denotes	TNF-α
T13023	837-839	IN	denotes	of
T13022	828-836	NN	denotes	blockade
T13021	826-827	,	denotes	,
T13020	815-826	RB	denotes	Furthermore
T13019	813-814	.	denotes	.
T13018	812-813	-RRB-	denotes	)
T13017	805-812	CD	denotes	TNFp75R
T13016	804-805	-LRB-	denotes	(
T13015	798-803	NNS	denotes	cells
T13014	786-797	JJ	denotes	endothelial
T13013	782-785	CC	denotes	and
T13012	780-781	-RRB-	denotes	)
T13011	773-780	NNP	denotes	TNFp75R
T13010	769-772	CC	denotes	and
T13009	761-768	CD	denotes	TNFp55R
T13008	760-761	-LRB-	denotes	(
T13007	749-759	NNS	denotes	astrocytes
T13006	746-748	IN	denotes	in
R10560	T13373	T13377	nmod	[,immunoreactivity
R10561	T13374	T13375	nummod	40,]
R10562	T13375	T13373	appos	],[
R10563	T13376	T13377	punct	),immunoreactivity
R10564	T13377	T13379	nsubjpass	immunoreactivity,detected
R10565	T13378	T13379	auxpass	was,detected
R10566	T13379	T13379	ROOT	detected,detected
R10567	T13380	T13379	prep	in,detected
R10568	T13381	T13382	compound	blood,vessels
R10569	T13382	T13380	pobj	vessels,in
R10574	T13387	T13384	pobj	end-feet,in
R10575	T13388	T13379	punct	",",detected
R10576	T13389	T13379	cc	and,detected
R10577	T13390	T13379	conj	was,detected
R10578	T13391	T13390	acomp	down-regulated,was
R10579	T13392	T13393	nummod	12,hrs
R10580	T13393	T13391	npadvmod	hrs,down-regulated
R10581	T13394	T13390	prep	after,was
R10582	T13395	T13396	nsubj	SE,prior
R10583	T13396	T13390	advmod	prior,was
R10080	T12893	T12895	det	The,findings
R10081	T12894	T12895	amod	major,findings
R10082	T12895	T12900	nsubj	findings,are
R10083	T12896	T12895	prep	in,findings
R10084	T12897	T12899	det	the,study
R10085	T12898	T12899	amod	present,study
R10086	T12899	T12896	pobj	study,in
R10087	T12900	T12900	ROOT	are,are
R10088	T12901	T12904	mark	that,showed
R10089	T12902	T12904	nsubj	TNF-α,showed
R10090	T12903	T12902	acl	signaling,TNF-α
R10091	T12904	T12900	ccomp	showed,are
R10092	T12905	T12907	amod	cellular,responses
R10093	T12906	T12907	amod	specific,responses
R10094	T12907	T12904	dobj	responses,showed
R10095	T12908	T12907	prep	of,responses
R10096	T12909	T12910	amod	NF-κB,phosphorylation
R10097	T12910	T12908	pobj	phosphorylation,of
R10098	T12911	T12910	prep	in,phosphorylation
R10099	T12912	T12913	det	the,PC
R10100	T12913	T12911	pobj	PC,in
R10101	T12914	T12907	prep	following,responses
R10102	T12915	T12914	pobj	SE,following
R10103	T12916	T12915	punct	",",SE
R10104	T12917	T12920	nsubjpass	which,related
R10105	T12918	T12920	aux	may,related
R10106	T12919	T12920	auxpass	be,related
R10107	T12920	T12915	relcl	related,SE
R10108	T12921	T12920	prep	to,related
R10109	T12922	T12924	amod	vasogenic,formation
R10110	T12923	T12924	compound	edema,formation
R10111	T12924	T12921	pobj	formation,to
R10112	T12925	T12924	acl	followed,formation
R10113	T12926	T12925	agent	by,followed
R10114	T12927	T12928	compound	neutrophil,infiltration
R10115	T12928	T12926	pobj	infiltration,by
R10116	T12929	T12900	punct	.,are
R10117	T12930	T12931	compound	BBB,disruption
R10118	T12931	T12934	nsubjpass	disruption,reported
R10119	T12932	T12934	aux	has,reported
R10120	T12933	T12934	auxpass	been,reported
R10121	T12934	T12934	ROOT	reported,reported
R10122	T12935	T12934	prep	in,reported
R10123	T12936	T12939	amod	experimental,epilepsy
R10124	T12937	T12936	cc	and,experimental
R10125	T12938	T12936	conj	human,experimental
R10126	T12939	T12935	pobj	epilepsy,in
R10127	T12940	T12942	compound	[,]
R10128	T12941	T12942	compound	"12,13,15,16,28",]
R10129	T12942	T12934	npadvmod	],reported
R10130	T12943	T12934	punct	.,reported
R10131	T12944	T12953	nsubjpass	Leakage,associated
R10132	T12945	T12944	prep	of,Leakage
R10133	T12946	T12947	amod	serum-derived,components
R10134	T12947	T12945	pobj	components,of
R10135	T12948	T12944	prep	into,Leakage
R10136	T12949	T12951	det	the,space
R10137	T12950	T12951	amod	extracellular,space
R10138	T12951	T12948	pobj	space,into
R10139	T12952	T12953	auxpass	is,associated
R10140	T12953	T12953	ROOT	associated,associated
R10141	T12954	T12953	prep	with,associated
R10142	T12955	T12954	pobj	hyperexcitability,with
R10143	T12956	T12955	cc	and,hyperexcitability
R10144	T12957	T12958	compound	seizure,onset
R10145	T12958	T12955	conj	onset,hyperexcitability
R10146	T12959	T12961	compound	[,]
R10147	T12960	T12961	compound	"12,13,15,16,28",]
R10148	T12961	T12955	appos	],hyperexcitability
R10149	T12962	T12953	punct	.,associated
R10150	T12963	T12969	advmod	Furthermore,leads
R10151	T12964	T12969	punct	",",leads
R10152	T12965	T12969	nsubj	dysfunction,leads
R10153	T12966	T12965	prep	of,dysfunction
R10154	T12967	T12968	det	the,BBB
R10155	T12968	T12966	pobj	BBB,of
R10156	T12969	T12969	ROOT	leads,leads
R10157	T12970	T12971	aux	to,epileptogenesis
R10158	T12971	T12969	xcomp	epileptogenesis,leads
R10159	T12972	T12969	cc	and,leads
R10160	T12973	T12969	conj	contributes,leads
R10161	T12974	T12973	prep	to,contributes
R10162	T12975	T12974	pobj	progression,to
R10163	T12976	T12975	prep	of,progression
R10164	T12977	T12976	pobj	epilepsy,of
R10165	T12978	T12980	compound	[,]
R10166	T12979	T12980	compound	"12,13,15,16,28",]
R10167	T12980	T12975	appos	],progression
R10168	T12981	T12969	punct	.,leads
R10169	T12982	T12991	prep	In,observed
R10170	T12983	T12985	det	the,study
R10171	T12984	T12985	amod	present,study
R10172	T12985	T12982	pobj	study,In
R10173	T12986	T12991	punct	",",observed
R10174	T12987	T12988	amod	TNF-α,immunoreactivity
R10175	T12988	T12991	nsubjpass	immunoreactivity,observed
R10176	T12989	T12991	auxpass	was,observed
R10177	T12990	T12991	advmod	obviously,observed
R10178	T12991	T12991	ROOT	observed,observed
R10179	T12992	T12991	prep	in,observed
R10180	T12993	T12992	pobj	microglia,in
R10181	T12994	T12991	prep	in,observed
R10182	T12995	T12996	det	the,PC
R10183	T12996	T12994	pobj	PC,in
R10184	T12997	T12991	prep	following,observed
R10185	T12998	T12997	dobj	SE,following
R10186	T12999	T12991	punct	.,observed
R10187	T13000	T13002	compound	TNF,expressions
R10188	T13001	T13002	compound	receptor,expressions
R10189	T13002	T13003	nsubj	expressions,were
R10190	T13003	T13003	ROOT	were,were
R10191	T13004	T13003	advmod	also,were
R10192	T13005	T13003	acomp	up-regulated,were
R10193	T13006	T13005	prep	in,up-regulated
R10194	T13007	T13006	pobj	astrocytes,in
R10195	T13008	T13007	punct	(,astrocytes
R10196	T13009	T13007	appos	TNFp55R,astrocytes
R10197	T13010	T13009	cc	and,TNFp55R
R10198	T13011	T13015	nmod	TNFp75R,cells
R10199	T13012	T13011	punct	),TNFp75R
R10200	T13013	T13011	cc	and,TNFp75R
R10201	T13014	T13011	conj	endothelial,TNFp75R
R10202	T13015	T13009	conj	cells,TNFp55R
R10203	T13016	T13015	punct	(,cells
R10204	T13017	T13015	appos	TNFp75R,cells
R10205	T13018	T13015	punct	),cells
R10206	T13019	T13003	punct	.,were
R10207	T13020	T13035	advmod	Furthermore,reduced
R10208	T13021	T13035	punct	",",reduced
R10209	T13022	T13035	nsubj	blockade,reduced
R10210	T13023	T13022	prep	of,blockade
R10211	T13024	T13023	pobj	TNF-α,of
R10212	T13025	T13022	acl	signaling,blockade
R10213	T13026	T13025	prep	by,signaling
R10214	T13027	T13026	pobj	sTNFp55,by
R10215	T13028	T13035	nsubj	infusion,reduced
R10216	T13029	T13035	advmod	effectively,reduced
R10217	T13030	T13029	punct	(,effectively
R10218	T13031	T13035	cc	but,reduced
R10219	T13032	T13033	neg	not,completely
R10220	T13033	T13035	advmod	completely,reduced
R10221	T13034	T13035	punct	),reduced
R10222	T13035	T13035	ROOT	reduced,reduced
R10223	T13036	T13035	dobj	volumes,reduced
R10224	T13037	T13036	prep	of,volumes
R10225	T13038	T13040	amod	SE-induced,edema
R10226	T13039	T13040	amod	vasogenic,edema
R10227	T13040	T13037	pobj	edema,of
R10228	T13041	T13040	cc	and,edema
R10229	T13042	T13043	amod	neuronal,damage
R10230	T13043	T13040	conj	damage,edema
R10231	T13044	T13043	prep	in,damage
R10232	T13045	T13046	det	the,PC
R10233	T13046	T13044	pobj	PC,in
R10234	T13047	T13035	punct	.,reduced
R10235	T13048	T13049	det	These,findings
R10236	T13049	T13050	nsubj	findings,indicate
R10237	T13050	T13050	ROOT	indicate,indicate
R10238	T13051	T13054	mark	that,participate
R10239	T13052	T13054	nsubj	TNF-α,participate
R10240	T13053	T13054	aux	may,participate
R10241	T13054	T13050	ccomp	participate,indicate
R10242	T13055	T13054	prep	in,participate
R10243	T13056	T13059	amod	astroglial,responses
R10244	T13057	T13056	cc	and,astroglial
R10245	T13058	T13056	conj	endothelial,astroglial
R10246	T13059	T13055	pobj	responses,in
R10247	T13060	T13059	prep	to,responses
R10248	T13061	T13060	pobj	SE,to
R10249	T13062	T13061	punct	",",SE
R10250	T13063	T13064	nsubj	which,are
R10251	T13064	T13061	relcl	are,SE
R10252	T13065	T13064	acomp	relevant,are
R10253	T13066	T13065	prep	to,relevant
R10254	T13067	T13070	amod	SE-induced,formation
R10255	T13068	T13070	amod	vasogenic,formation
R10256	T13069	T13070	compound	edema,formation
R10257	T13070	T13066	pobj	formation,to
R10258	T13071	T13073	nmod	[,]
R10259	T13072	T13073	nummod	5-8,]
R10260	T13073	T13070	appos	],formation
R10261	T13074	T13050	punct	.,indicate
R10262	T13075	T13078	advmod	Indeed,signaling
R10263	T13076	T13078	punct	",",signaling
R10264	T13077	T13078	amod	TNF-α,signaling
R10265	T13078	T13078	ROOT	signaling,signaling
R10266	T13079	T13081	nmod	increases,permeability
R10267	T13080	T13081	compound	BBB,permeability
R10268	T13081	T13078	dobj	permeability,signaling
R10269	T13082	T13081	prep	in,permeability
R10270	T13083	T13086	amod	various,models
R10271	T13084	T13086	amod	experimental,models
R10272	T13085	T13086	compound	disease,models
R10273	T13086	T13082	pobj	models,in
R10274	T13087	T13089	quantmod	[,]
R10275	T13088	T13089	nummod	29,]
R10276	T13089	T13078	nsubj	],signaling
R10277	T13090	T13078	punct	.,signaling
R10278	T13091	T13101	prep	In,prevent
R10279	T13092	T13094	det	the,study
R10280	T13093	T13094	amod	present,study
R10281	T13094	T13091	pobj	study,In
R10282	T13095	T13101	punct	",",prevent
R10283	T13096	T13097	amod	sTNFp55,infusion
R10284	T13097	T13101	nsubj	infusion,prevent
R10285	T13098	T13101	aux	could,prevent
R10286	T13099	T13101	neg	not,prevent
R10287	T13100	T13101	advmod	completely,prevent
R10288	T13101	T13101	ROOT	prevent,prevent
R10289	T13102	T13104	nmod	SE-induced,edema
R10290	T13103	T13104	amod	vasogenic,edema
R10291	T13104	T13101	dobj	edema,prevent
R10292	T13105	T13104	cc	and,edema
R10293	T13106	T13107	amod	neuronal,damage
R10294	T13107	T13104	conj	damage,edema
R10295	T13108	T13107	prep	in,damage
R10296	T13109	T13110	det	the,PC
R10297	T13110	T13108	pobj	PC,in
R10298	T13111	T13101	punct	.,prevent
R10299	T13112	T13116	advmod	Therefore,suggest
R10300	T13113	T13116	punct	",",suggest
R10301	T13114	T13115	poss	our,findings
R10302	T13115	T13116	nsubj	findings,suggest
R10303	T13116	T13116	ROOT	suggest,suggest
R10304	T13117	T13122	mark	that,be
R10305	T13118	T13119	amod	TNF-α,signaling
R10306	T13119	T13122	csubj	signaling,be
R10307	T13120	T13122	aux	may,be
R10308	T13121	T13122	neg	not,be
R10309	T13122	T13116	ccomp	be,suggest
R10310	T13123	T13126	det	a,event
R10311	T13124	T13126	amod	unique,event
R10312	T13125	T13126	compound	upstream,event
R10313	T13126	T13122	attr	event,be
R10314	T13127	T13126	prep	in,event
R10315	T13128	T13130	amod	vasogenic,development
R10316	T13129	T13130	compound	edema,development
R10317	T13130	T13127	pobj	development,in
R10318	T13131	T13116	punct	.,suggest
R10319	T13132	T13133	compound	p65,phosphorylation
R10320	T13133	T13136	nsubj	phosphorylation,enhances
R10321	T13134	T13133	prep	of,phosphorylation
R10322	T13135	T13134	pobj	NF-κB,of
R10323	T13136	T13136	ROOT	enhances,enhances
R10324	T13137	T13139	poss	its,potential
R10325	T13138	T13139	compound	transactivation,potential
R10326	T13139	T13136	dobj	potential,enhances
R10327	T13140	T13136	punct	",",enhances
R10328	T13141	T13136	cc	and,enhances
R10329	T13142	T13144	nummod	p65,occurs
R10330	T13143	T13144	nsubj	phosphorylation,occurs
R10331	T13144	T13136	conj	occurs,enhances
R10332	T13145	T13144	prep	in,occurs
R10333	T13146	T13148	preconj	either,cytoplasm
R10334	T13147	T13148	det	the,cytoplasm
R10335	T13148	T13145	pobj	cytoplasm,in
R10336	T13149	T13148	cc	or,cytoplasm
R10337	T13150	T13151	det	the,nucleus
R10338	T13151	T13148	conj	nucleus,cytoplasm
R10339	T13152	T13154	quantmod	[,]
R10340	T13153	T13154	nummod	30,]
R10341	T13154	T13151	appos	],nucleus
R10342	T13155	T13144	punct	.,occurs
R10343	T13156	T13164	prep	In,detected
R10344	T13157	T13159	det	the,study
R10345	T13158	T13159	amod	present,study
R10346	T13159	T13156	pobj	study,In
R10347	T13160	T13164	punct	",",detected
R10348	T13161	T13162	compound	p65-Thr435,immunoreactivity
R10349	T13162	T13164	nsubjpass	immunoreactivity,detected
R10350	T13163	T13164	auxpass	was,detected
R10351	T13164	T13164	ROOT	detected,detected
R10352	T13165	T13164	prep	in,detected
R10353	T13166	T13167	amod	endothelial,cells
R10354	T13167	T13165	pobj	cells,in
R10355	T13168	T13164	punct	",",detected
R10356	T13169	T13164	cc	and,detected
R10357	T13170	T13171	poss	its,immunoreactivity
R10358	T13171	T13172	nsubj	immunoreactivity,showed
R10359	T13172	T13164	conj	showed,detected
R10360	T13173	T13175	det	an,correlation
R10361	T13174	T13175	amod	inverse,correlation
R10362	T13175	T13172	dobj	correlation,showed
R10363	T13176	T13175	prep	to,correlation
R10364	T13177	T13178	det	the,degree
R10365	T13178	T13176	pobj	degree,to
R10366	T13179	T13178	prep	of,degree
R10367	T13180	T13181	compound	SMI-71,expression
R10368	T13181	T13179	pobj	expression,of
R10369	T13182	T13172	punct	.,showed
R10370	T13183	T13190	nsubj	SMI-71,is
R10371	T13184	T13183	punct	",",SMI-71
R10372	T13185	T13188	det	an,antigen
R10373	T13186	T13188	amod	endothelial,antigen
R10374	T13187	T13188	compound	barrier,antigen
R10375	T13188	T13183	appos	antigen,SMI-71
R10376	T13189	T13190	punct	",",is
R10377	T13190	T13190	ROOT	is,is
R10378	T13191	T13192	det	a,protein
R10379	T13192	T13190	attr	protein,is
R10380	T13193	T13192	acl	expressed,protein
R10381	T13194	T13193	agent	by,expressed
R10382	T13195	T13196	amod	endothelial,cells
R10383	T13196	T13194	pobj	cells,by
R10384	T13197	T13196	prep	of,cells
R10385	T13198	T13199	compound	rat,BBB
R10386	T13199	T13200	compound	BBB,[
R10387	T13200	T13197	pobj	[,of
R10388	T13201	T13202	nummod	31,]
R10389	T13202	T13196	appos	],cells
R10390	T13203	T13190	punct	.,is
R10391	T13204	T13211	prep	Under,lost
R10392	T13205	T13206	amod	pathological,conditions
R10393	T13206	T13204	pobj	conditions,Under
R10394	T13207	T13211	punct	",",lost
R10395	T13208	T13209	compound	SMI-71,expression
R10396	T13209	T13211	nsubjpass	expression,lost
R10397	T13210	T13211	auxpass	is,lost
R10398	T13211	T13211	ROOT	lost,lost
R10399	T13212	T13211	prep	in,lost
R10400	T13213	T13214	amod	endothelial,cells
R10401	T13214	T13212	pobj	cells,in
R10402	T13215	T13217	compound	[,]
R10403	T13216	T13217	compound	"5,7,8,30,32",]
R10404	T13217	T13211	dobj	],lost
R10405	T13218	T13211	punct	.,lost
R10406	T13219	T13220	amod	Acute,phases
R10407	T13220	T13227	nsubjpass	phases,accompanied
R10408	T13221	T13220	prep	of,phases
R10409	T13222	T13225	det	the,conditions
R10410	T13223	T13225	amod	above,conditions
R10411	T13224	T13225	amod	pathological,conditions
R10412	T13225	T13221	pobj	conditions,of
R10413	T13226	T13227	auxpass	are,accompanied
R10414	T13227	T13227	ROOT	accompanied,accompanied
R10415	T13228	T13227	agent	by,accompanied
R10416	T13229	T13228	pobj	opening,by
R10417	T13230	T13229	prep	of,opening
R10418	T13231	T13232	det	the,BBB
R10419	T13232	T13230	pobj	BBB,of
R10420	T13233	T13232	cc	and,BBB
R10421	T13234	T13230	pobj	development,of
R10422	T13235	T13234	prep	of,development
R10423	T13236	T13237	amod	vasogenic,edema
R10424	T13237	T13235	pobj	edema,of
R10425	T13238	T13240	nmod	[,]
R10426	T13239	T13240	nummod	33,]
R10427	T13240	T13237	appos	],edema
R10428	T13241	T13227	punct	.,accompanied
R10429	T13242	T13249	advmod	Indeed,leads
R10430	T13243	T13249	punct	",",leads
R10431	T13244	T13249	nsubj	neutralization,leads
R10432	T13245	T13244	prep	of,neutralization
R10433	T13246	T13245	pobj	SMI-71,of
R10434	T13247	T13244	prep	in,neutralization
R10435	T13248	T13247	pobj	vivo,in
R10436	T13249	T13249	ROOT	leads,leads
R10437	T13250	T13249	prep	to,leads
R10438	T13251	T13250	pcomp	widening,to
R10439	T13252	T13251	prep	of,widening
R10440	T13253	T13254	amod	intercellular,junctions
R10441	T13254	T13252	pobj	junctions,of
R10442	T13255	T13254	prep	between,junctions
R10443	T13256	T13257	amod	endothelial,cells
R10444	T13257	T13255	pobj	cells,between
R10445	T13258	T13257	cc	and,cells
R10446	T13259	T13251	conj	swelling,widening
R10447	T13260	T13259	prep	of,swelling
R10448	T13261	T13263	amod	perivascular,processes
R10449	T13262	T13263	amod	astrocytic,processes
R10450	T13263	T13260	pobj	processes,of
R10451	T13264	T13266	nmod	[,]
R10452	T13265	T13266	nummod	34,]
R10453	T13266	T13250	pobj	],to
R10454	T13267	T13249	punct	",",leads
R10455	T13268	T13272	mark	although,localized
R10456	T13269	T13272	nsubjpass	SMI-71,localized
R10457	T13270	T13272	auxpass	is,localized
R10458	T13271	T13272	neg	not,localized
R10459	T13272	T13249	advcl	localized,leads
R10460	T13273	T13272	prep	at,localized
R10461	T13274	T13275	amod	endothelial,cell
R10462	T13275	T13276	compound	cell,junctions
R10463	T13276	T13273	pobj	junctions,at
R10464	T13277	T13279	compound	[,]
R10465	T13278	T13279	compound	35-38,]
R10466	T13279	T13272	npadvmod	],localized
R10467	T13280	T13249	punct	.,leads
R10468	T13281	T13290	prep	In,reduced
R10469	T13282	T13284	det	the,study
R10470	T13283	T13284	amod	present,study
R10471	T13284	T13281	pobj	study,In
R10584	T13397	T13396	prep	to,prior
R10585	T13398	T13399	det	the,appearance
R10586	T13399	T13397	pobj	appearance,to
R10587	T13400	T13399	prep	of,appearance
R10588	T13401	T13402	amod	vasogenic,edema
R10589	T13402	T13400	pobj	edema,of
R10590	T13403	T13402	cc	and,edema
R10591	T13404	T13402	conj	down-regulation,edema
R10592	T13405	T13402	prep	of,edema
R10593	T13406	T13407	compound	SMI-71,immunoreactivity
R10594	T13407	T13405	pobj	immunoreactivity,of
R10595	T13408	T13379	punct	.,detected
R10596	T13409	T13421	prep	With,be
R10597	T13410	T13409	pobj	respect,With
R10598	T13411	T13410	prep	to,respect
R10599	T13412	T13414	det	this,report
R10600	T13413	T13414	amod	previous,report
R10601	T13414	T13411	pobj	report,to
R10602	T13415	T13421	punct	",",be
R10603	T13416	T13421	nsubj	changes,be
R10604	T13417	T13416	prep	in,changes
R10605	T13418	T13419	compound	SMI,immunoreactivity
R10606	T13419	T13417	pobj	immunoreactivity,in
R10607	T13420	T13421	aux	would,be
R10608	T13421	T13421	ROOT	be,be
R10609	T13422	T13421	attr	causes/results,be
R10610	T13423	T13422	prep	of,causes/results
R10611	T13424	T13423	pobj	interaction,of
R10612	T13425	T13424	prep	between,interaction
R10613	T13426	T13427	amod	endothelial,cells
R10614	T13427	T13425	pobj	cells,between
R10615	T13428	T13427	cc	and,cells
R10616	T13429	T13430	amod	perivascular,astrocytes
R10617	T13430	T13427	conj	astrocytes,cells
R10618	T13431	T13421	punct	.,be
R10619	T13432	T13447	prep	In,observed
R10620	T13433	T13435	det	the,study
R10621	T13434	T13435	amod	present,study
R10622	T13435	T13432	pobj	study,In
R10623	T13436	T13447	punct	",",observed
R10624	T13437	T13447	nsubjpass	p65-Ser276,observed
R10625	T13438	T13437	punct	",",p65-Ser276
R10626	T13439	T13437	conj	p65-Ser311,p65-Ser276
R10627	T13440	T13439	punct	",",p65-Ser311
R10628	T13441	T13439	conj	p65-Ser529,p65-Ser311
R10629	T13442	T13441	punct	",",p65-Ser529
R10630	T13443	T13441	cc	and,p65-Ser529
R10631	T13444	T13445	compound	p65-Ser536,phosphorylation
R10632	T13445	T13441	conj	phosphorylation,p65-Ser529
R10633	T13446	T13447	auxpass	was,observed
R10634	T13447	T13447	ROOT	observed,observed
R10635	T13448	T13447	prep	in,observed
R10636	T13449	T13448	pobj	astrocytes,in
R10637	T13450	T13449	prep	following,astrocytes
R10638	T13451	T13450	dobj	SE,following
R10639	T13452	T13447	punct	.,observed
R10640	T13453	T13458	advmod	Furthermore,inhibited
R10641	T13454	T13458	punct	",",inhibited
R10642	T13455	T13456	amod	sTNFp55R,infusion
R10643	T13456	T13458	nsubj	infusion,inhibited
R10644	T13457	T13458	advmod	effectively,inhibited
R10645	T13458	T13458	ROOT	inhibited,inhibited
R10646	T13459	T13458	dobj	p65-Ser276,inhibited
R10647	T13460	T13459	cc	and,p65-Ser276
R10648	T13461	T13459	conj	p65-Ser311phosphorylation,p65-Ser276
R10649	T13462	T13458	prep	in,inhibited
R10650	T13463	T13462	pobj	astrocytes,in
R10651	T13464	T13463	prep	following,astrocytes
R10652	T13465	T13464	pobj	SE,following
R10653	T13466	T13458	punct	.,inhibited
R10654	T13467	T13470	advmod	Therefore,is
R10655	T13468	T13470	punct	",",is
R10656	T13469	T13470	nsubj	it,is
R10657	T13470	T13470	ROOT	is,is
R10658	T13471	T13470	acomp	likely,is
R10659	T13472	T13480	mark	that,involved
R10660	T13473	T13474	amod	enhanced,p65-Ser276
R10661	T13474	T13480	nsubjpass	p65-Ser276,involved
R10662	T13475	T13474	cc	and,p65-Ser276
R10663	T13476	T13477	compound	p65-Ser311,phosphorylation
R10664	T13477	T13474	conj	phosphorylation,p65-Ser276
R10665	T13478	T13480	aux	may,involved
R10666	T13479	T13480	auxpass	be,involved
R10667	T13480	T13470	ccomp	involved,is
R10668	T13481	T13480	prep	in,involved
R10669	T13482	T13483	compound	TNF-α-mediated,BBB
R10670	T13483	T13484	compound	BBB,disruption
R10671	T13484	T13481	pobj	disruption,in
R10672	T13485	T13470	punct	.,is
R10673	T13486	T13492	advmod	However,prevent
R10674	T13487	T13492	punct	",",prevent
R10675	T13488	T13489	amod	sTNFp55R,infusion
R10676	T13489	T13492	nsubj	infusion,prevent
R10677	T13490	T13492	aux	could,prevent
R10678	T13491	T13492	neg	not,prevent
R10679	T13492	T13492	ROOT	prevent,prevent
R10680	T13493	T13492	dobj	p65-Ser529,prevent
R10681	T13494	T13493	cc	and,p65-Ser529
R10682	T13495	T13493	conj	p65-Ser536,p65-Ser529
R10683	T13496	T13493	conj	phosphorylations,p65-Ser529
R10684	T13497	T13496	prep	from,phosphorylations
R10685	T13498	T13499	compound	SE,insults
R10686	T13499	T13497	pobj	insults,from
R10687	T13500	T13492	punct	.,prevent
R10688	T13501	T13506	mark	Since,phosphorylated
R10689	T13502	T13505	nsubj	p65-Ser529,are
R10690	T13503	T13502	cc	and,p65-Ser529
R10691	T13504	T13502	conj	p65-Ser536,p65-Ser529
R10692	T13505	T13506	auxpass	are,phosphorylated
R10693	T13506	T13516	advcl	phosphorylated,is
R10694	T13507	T13506	agent	by,phosphorylated
R10695	T13508	T13507	pobj	TNF-α,by
R10696	T13509	T13508	cc	and,TNF-α
R10697	T13510	T13511	compound	IL-1β,[
R10698	T13511	T13508	conj	[,TNF-α
R10699	T13512	T13513	nummod	41,]
R10700	T13513	T13513	ROOT	],]
R10701	T13514	T13516	punct	",",is
R10702	T13515	T13516	nsubj	it,is
R10703	T13516	T13516	ROOT	is,is
R10704	T13517	T13516	acomp	likely,is
R10705	T13518	T13526	mark	that,play
R10706	T13519	T13523	amod	IL-1β-mediated,phosphorylation
R10707	T13520	T13521	amod	p65-Ser529,/
R10708	T13521	T13523	compound	/,phosphorylation
R10709	T13522	T13523	compound	Ser536,phosphorylation
R10710	T13523	T13526	nsubj	phosphorylation,play
R10711	T13524	T13526	aux	may,play
R10712	T13525	T13526	advmod	also,play
R10713	T13526	T13517	ccomp	play,likely
R10714	T13527	T13528	det	a,role
R10715	T13528	T13526	dobj	role,play
R10716	T13529	T13528	prep	in,role
R10717	T13530	T13532	amod	SE-induced,edema
R10718	T13531	T13532	amod	vasogenic,edema
R10719	T13532	T13529	pobj	edema,in
R10720	T13533	T13516	punct	.,is
R10721	T13534	T13538	advmod	Therefore,indicate
R10722	T13535	T13538	punct	",",indicate
R10723	T13536	T13537	poss	our,findings
R10724	T13537	T13538	nsubj	findings,indicate
R10725	T13538	T13563	nmod	indicate,role
R10726	T13539	T13545	mark	that,be
R10727	T13540	T13541	preconj	both,TNF-α
R10728	T13541	T13545	nsubj	TNF-α,be
R10729	T13542	T13541	cc	and,TNF-α
R10730	T13543	T13541	conj	IL-1β,TNF-α
R10731	T13544	T13545	aux	may,be
R10732	T13545	T13538	ccomp	be,indicate
R10733	T13546	T13545	attr	synergists,be
R10734	T13547	T13548	aux	to,play
R10735	T13548	T13545	xcomp	play,be
R10736	T13549	T13553	preconj	either,by
R10737	T13550	T13553	det	a,by
R10738	T13551	T13553	amod	direct,by
R10739	T13552	T13553	punct	(,by
R10740	T13553	T13548	prep	by,play
R10741	T13554	T13555	amod	endothelial,cells
R10742	T13555	T13553	pobj	cells,by
R10743	T13556	T13538	punct	),indicate
R10744	T13557	T13538	cc	or,indicate
R10745	T13558	T13538	conj	indirect,indicate
R10746	T13559	T13560	punct	(,by
R10747	T13560	T13558	prep	by,indirect
R10748	T13561	T13560	pobj	astrocytes,by
R10749	T13562	T13563	punct	),role
R10750	T13563	T13563	ROOT	role,role
R10751	T13564	T13563	prep	in,role
R10752	T13565	T13566	det	the,maintenance
R10753	T13566	T13564	pobj	maintenance,in
R10754	T13567	T13566	prep	of,maintenance
R10755	T13568	T13569	compound	BBB,permeability
R10756	T13569	T13567	pobj	permeability,of
R10757	T13570	T13563	punct	.,role
R10758	T13571	T13572	compound	Neutrophil,infiltration
R10759	T13572	T13578	nsubjpass	infiltration,observed
R10760	T13573	T13572	prep	into,infiltration
R10761	T13574	T13575	compound	brain,parenchyma
R10762	T13575	T13573	pobj	parenchyma,into
R10763	T13576	T13578	auxpass	is,observed
R10764	T13577	T13578	advmod	transiently,observed
R10765	T13578	T13578	ROOT	observed,observed
R10766	T13579	T13578	prep	during,observed
R10767	T13580	T13582	det	the,phase
R10768	T13581	T13582	amod	acute,phase
R10769	T13582	T13579	pobj	phase,during
R10770	T13583	T13582	prep	of,phase
R10771	T13584	T13583	pobj	SE,of
R10772	T13585	T13586	punct	(,4
R10773	T13586	T13588	meta	4,36
R10774	T13587	T13588	punct	-,36
R10775	T13588	T13589	nummod	36,hr
R10776	T13589	T13582	appos	hr,phase
R10777	T13590	T13589	prep	after,hr
R10778	T13591	T13590	pobj	SE,after
R10779	T13592	T13582	punct	),phase
R10780	T13593	T13578	cc	and,observed
R10781	T13594	T13578	conj	disappears,observed
R10782	T13595	T13596	advmod	thereafter,[
R10783	T13596	T13598	amod	[,]
R10784	T13597	T13598	nummod	20,]
R10785	T13598	T13594	dobj	],disappears
R10788	T13601	T13602	advmod	rapidly,increases
R10789	T13602	T13602	ROOT	increases,increases
R10790	T13603	T13602	dobj	synthesis,increases
R10791	T13604	T13603	cc	and,synthesis
R10792	T13605	T13603	conj	release,synthesis
R10793	T13606	T13605	prep	of,release
R10794	T13607	T13606	pobj	chemokines,of
R10795	T13608	T13607	prep	in,chemokines
R10796	T13609	T13610	amod	various,areas
R10797	T13610	T13608	pobj	areas,in
R10798	T13611	T13610	prep	of,areas
R10799	T13612	T13614	det	the,brain
R10800	T13613	T13614	compound	rodent,brain
R10801	T13614	T13611	pobj	brain,of
R10802	T13615	T13617	nmod	[,]
R10803	T13616	T13617	nummod	42,]
R10804	T13617	T13605	nmod	],release
R10805	T13618	T13602	punct	.,increases
R10806	T13619	T13624	prep	Among,required
R10807	T13620	T13619	pobj	them,Among
R10808	T13621	T13624	punct	",",required
R10809	T13622	T13624	nsubjpass	MIP-2,required
R10810	T13623	T13624	auxpass	is,required
R10811	T13624	T13624	ROOT	required,required
R10812	T13625	T13624	prep	for,required
R10813	T13626	T13627	amod	efficient,neutrophil
R10814	T13627	T13625	pobj	neutrophil,for
R10815	T13628	T13627	cc	or,neutrophil
R10816	T13629	T13630	compound	lymphocyte,recruitment
R10817	T13630	T13627	conj	recruitment,neutrophil
R10818	T13631	T13627	prep	to,neutrophil
R10819	T13632	T13631	pobj	brain,to
R10820	T13633	T13634	compound	parenchyma,[
R10821	T13634	T13624	dobj	[,required
R10822	T13635	T13636	nummod	43,]
R10823	T13636	T13634	appos	],[
R10824	T13637	T13624	punct	.,required
R10825	T13638	T13653	prep	In,regulated
R10826	T13639	T13641	poss	our,study
R10827	T13640	T13641	amod	previous,study
R10828	T13641	T13638	pobj	study,In
R10829	T13642	T13644	nmod	[,]
R10830	T13643	T13644	nummod	20,]
R10831	T13644	T13647	nmod	],infiltration
R10832	T13645	T13647	punct	",",infiltration
R10833	T13646	T13647	compound	neutrophil,infiltration
R10834	T13647	T13653	nsubjpass	infiltration,regulated
R10835	T13648	T13647	prep	in,infiltration
R10836	T13649	T13651	det	the,cortex
R10837	T13650	T13651	amod	frontoparietal,cortex
R10838	T13651	T13648	pobj	cortex,in
R10839	T13652	T13653	auxpass	was,regulated
R10840	T13653	T13653	ROOT	regulated,regulated
R10841	T13654	T13653	agent	by,regulated
R10842	T13655	T13654	pobj	P2X7,by
R10843	T13656	T13658	amod	receptor-mediated,expression
R10844	T13657	T13658	compound	MIP-2,expression
R10845	T13658	T13653	npadvmod	expression,regulated
R10846	T13659	T13653	punct	.,regulated
R10847	T13660	T13681	prep	In,affect
R10848	T13661	T13662	det	the,PC
R10849	T13662	T13660	pobj	PC,In
R10850	T13663	T13681	punct	",",affect
R10851	T13664	T13681	advmod	however,affect
R10852	T13665	T13681	punct	",",affect
R10853	T13666	T13678	preconj	neither,infusion
R10855	T13668	T13670	amod	P2X7,agonist/antagonist
R10856	T13669	T13670	compound	receptor,agonist/antagonist
R10857	T13670	T13678	amod	agonist/antagonist,infusion
R10858	T13671	T13670	cc	nor,agonist/antagonist
R10859	T13672	T13670	conj	IL-1Ra,agonist/antagonist
R10860	T13673	T13672	punct	(,IL-1Ra
R10861	T13674	T13676	det	an,antagonist
R10862	T13675	T13676	compound	IL-1β,antagonist
R10863	T13676	T13672	appos	antagonist,IL-1Ra
R10864	T13677	T13672	punct	),IL-1Ra
R10875	T13688	T13685	pobj	study,In
R10876	T13689	T13693	punct	",",inhibited
R10877	T13690	T13691	amod	sTNFp55R,infusion
R10878	T13691	T13693	nsubj	infusion,inhibited
R10879	T13692	T13693	advmod	effectively,inhibited
R10880	T13693	T13693	ROOT	inhibited,inhibited
R10881	T13694	T13695	compound	neutrophil,infiltration
R10882	T13695	T13693	dobj	infiltration,inhibited
R10883	T13696	T13695	prep	in,infiltration
R10884	T13697	T13698	det	the,PC
R10885	T13698	T13696	pobj	PC,in
R10886	T13699	T13693	prep	by,inhibited
R10887	T13700	T13699	pcomp	reducing,by
R10888	T13701	T13703	amod	vasogenic,formation
R10889	T13702	T13703	compound	edema,formation
R10890	T13703	T13700	dobj	formation,reducing
R10891	T13704	T13700	prep	in,reducing
R10892	T13705	T13707	det	a,manner
R10893	T13706	T13707	amod	MIP-2-independent,manner
R10894	T13707	T13704	pobj	manner,in
R10895	T13708	T13693	punct	.,inhibited
R10896	T13709	T13720	prep	With,is
R10897	T13710	T13709	pobj	respect,With
R10898	T13711	T13710	prep	to,respect
R10899	T13712	T13713	det	the,present
R10900	T13713	T13711	pobj	present,to
R10901	T13714	T13713	cc	and,present
R10902	T13715	T13717	poss	our,reports
R10903	T13716	T13717	amod	previous,reports
R10904	T13717	T13713	conj	reports,present
R10905	T13718	T13720	punct	",",is
R10906	T13719	T13720	nsubj	it,is
R10907	T13720	T13720	ROOT	is,is
R10908	T13721	T13722	advmod	therefore,likely
R10909	T13722	T13720	acomp	likely,is
R10910	T13723	T13730	mark	that,induce
R10911	T13724	T13725	amod	vasogenic,edema
R10912	T13725	T13730	nsubj	edema,induce
R10913	T13726	T13725	acl	induced,edema
R10914	T13727	T13726	agent	by,induced
R10915	T13728	T13727	pobj	TNF-α,by
R10916	T13729	T13730	aux	can,induce
R10917	T13730	T13722	ccomp	induce,likely
R10918	T13731	T13732	compound	neutrophil,infiltration
R10919	T13732	T13730	dobj	infiltration,induce
R10920	T13733	T13732	cc	and,infiltration
R10921	T13734	T13735	compound	press,injury
R10922	T13735	T13732	conj	injury,infiltration
R10923	T13736	T13737	aux	to,evoke
R10924	T13737	T13730	xcomp	evoke,induce
R10925	T13738	T13739	amod	neuronal-astroglial,loss
R10926	T13739	T13737	dobj	loss,evoke
R10927	T13740	T13737	prep	in,evoke
R10928	T13741	T13742	det	the,PC
R10929	T13742	T13740	pobj	PC,in
R10930	T13743	T13737	punct	",",evoke
R10931	T13744	T13730	prep	unlike,induce
R10932	T13764	T13767	amod	p65-Thr,phosphorylation
R10933	T13745	T13747	amod	other,regions
R10934	T13765	T13767	nummod	435,phosphorylation
R10935	T13746	T13747	compound	brain,regions
R10936	T13766	T13767	amod	NF-κB,phosphorylation
R10937	T13767	T13770	nsubjpass	phosphorylation,involved
R10938	T13747	T13744	pobj	regions,unlike
R10939	T13768	T13770	aux	may,involved
R10940	T13769	T13770	auxpass	be,involved
R10941	T13748	T13720	punct	.,is
R10942	T13770	T13754	ccomp	involved,reveal
R10943	T13771	T13770	prep	in,involved
R10944	T13772	T13774	amod	SE-induced,edema
R10945	T13749	T13754	prep	In,reveal
R10946	T13773	T13774	amod	vasogenic,edema
R10947	T13774	T13771	pobj	edema,in
R10948	T13775	T13774	punct	",",edema
R10949	T13750	T13749	pobj	conclusion,In
R10950	T13776	T13777	nsubj	which,is
R10951	T13777	T13774	relcl	is,edema
R10952	T13751	T13754	punct	",",reveal
R10953	T13778	T13777	acomp	relevant,is
R10954	T13779	T13780	aux	to,neutrophil
R10955	T13752	T13753	poss	our,findings
R10956	T13780	T13781	amod	neutrophil,infiltration
R10957	T13781	T13777	attr	infiltration,is
R10958	T13782	T13781	cc	and,infiltration
R10959	T13783	T13784	amod	neuronal-astroglial,loss
R10960	T13784	T13781	conj	loss,infiltration
R10961	T13785	T13754	punct	.,reveal
R10962	T13753	T13754	nsubj	findings,reveal
R10963	T13754	T13754	ROOT	reveal,reveal
R10964	T13755	T13763	mark	that,mediated
R10965	T13756	T13763	nsubj	impairments,mediated
R10966	T13757	T13756	prep	of,impairments
R10967	T13758	T13760	amod	endothelial,function
R10968	T13759	T13760	compound	cell,function
R10969	T13760	T13757	pobj	function,of
R10970	T13761	T13756	prep	via,impairments
R10971	T13762	T13763	nsubj	TNF-α,mediated
R10972	T13763	T13770	advcl	mediated,involved
R10472	T13285	T13290	punct	",",reduced
R10473	T13286	T13287	compound	SMI-71,immunoreactivity
R10474	T13287	T13290	nsubjpass	immunoreactivity,reduced
R10475	T13288	T13290	auxpass	was,reduced
R10476	T13289	T13290	advmod	significantly,reduced
R10477	T13290	T13290	ROOT	reduced,reduced
R10478	T13291	T13290	prep	in,reduced
R10479	T13292	T13293	compound	blood,vessels
R10480	T13293	T13291	pobj	vessels,in
R10481	T13294	T13295	nummod	1,day
R10482	T13295	T13290	npadvmod	day,reduced
R10483	T13296	T13305	mark	after,observed
R10484	T13297	T13296	pobj	SE,after
R10485	T13298	T13305	advmod	when,observed
R10486	T13299	T13300	amod	vasogenic,edema
R10487	T13300	T13305	nsubjpass	edema,observed
R10488	T13301	T13300	cc	and,edema
R10489	T13302	T13303	amod	neuronal,damage
R10490	T13303	T13300	conj	damage,edema
R10491	T13304	T13305	auxpass	were,observed
R10492	T13305	T13295	advcl	observed,day
R10493	T13306	T13290	punct	.,reduced
R10494	T13307	T13312	advmod	Furthermore,prevented
R10495	T13308	T13312	punct	",",prevented
R10496	T13309	T13310	amod	sTNFp55R,infusion
R10497	T13310	T13312	nsubj	infusion,prevented
R10498	T13311	T13312	advmod	effectively,prevented
R10499	T13312	T13312	ROOT	prevented,prevented
R10500	T13313	T13315	amod	SE-induced,down-regulation
R10501	T13314	T13315	compound	SMI-71,down-regulation
R10502	T13315	T13312	dobj	down-regulation,prevented
R10503	T13316	T13312	punct	.,prevented
R10504	T13317	T13332	prep	With,indicate
R10505	T13318	T13317	pobj	respect,With
R10506	T13319	T13318	prep	to,respect
R10507	T13320	T13321	det	the,phosphorylation
R10508	T13321	T13319	pobj	phosphorylation,to
R10509	T13322	T13321	prep	of,phosphorylation
R10510	T13323	T13322	pobj	p65-Thr435,of
R10511	T13324	T13321	prep	by,phosphorylation
R10512	T13325	T13326	compound	TNF-α,[
R10513	T13326	T13328	nmod	[,]
R10514	T13327	T13328	nummod	39,]
R10515	T13328	T13324	pobj	],by
R10516	T13329	T13332	punct	",",indicate
R10517	T13330	T13331	poss	our,findings
R10518	T13331	T13332	nsubj	findings,indicate
R10519	T13332	T13332	ROOT	indicate,indicate
R10520	T13333	T13341	mark	that,play
R10521	T13334	T13336	amod	TNF-α-mediated,phosphorylation
R10522	T13335	T13336	compound	p65-Thr435,phosphorylation
R10523	T13336	T13341	nsubj	phosphorylation,play
R10524	T13337	T13336	prep	in,phosphorylation
R10525	T13338	T13339	amod	endothelial,cells
R10526	T13339	T13337	pobj	cells,in
R10527	T13340	T13341	aux	may,play
R10528	T13341	T13332	ccomp	play,indicate
R10529	T13342	T13344	det	an,role
R10530	T13343	T13344	amod	important,role
R10531	T13344	T13341	dobj	role,play
R10532	T13345	T13341	prep	in,play
R10533	T13346	T13348	amod	vasogenic,induction
R10534	T13347	T13348	compound	edema,induction
R10535	T13348	T13345	pobj	induction,in
R10536	T13349	T13341	prep	via,play
R10537	T13350	T13351	compound	SMI-71,degradation
R10538	T13351	T13349	pobj	degradation,via
R10539	T13352	T13351	cc	or,degradation
R10540	T13353	T13355	poss	its,dysfunction
R10541	T13354	T13355	amod	posttranslational,dysfunction
R10542	T13355	T13351	conj	dysfunction,degradation
R10543	T13356	T13355	acl	influencing,dysfunction
R10544	T13357	T13358	compound	BBB,permeability
R10545	T13358	T13356	dobj	permeability,influencing
R10546	T13359	T13332	punct	.,indicate
R10547	T13360	T13379	prep	In,detected
R10548	T13361	T13363	poss	our,studies
R10549	T13362	T13363	amod	previous,studies
R10550	T13363	T13360	pobj	studies,In
R10551	T13364	T13366	compound	[,]
R10552	T13365	T13366	compound	"5,8",]
R10553	T13366	T13379	nsubjpass	],detected
R10554	T13367	T13366	punct	",",]
R10555	T13368	T13377	amod	dystrophin,immunoreactivity
R10556	T13369	T13372	punct	(,protein
R10557	T13370	T13372	det	an,protein
R10558	T13371	T13372	compound	actin-binding,protein
R10559	T13372	T13377	nmod	protein,immunoreactivity
R10570	T13383	T13380	cc	and,in
R10571	T13384	T13380	conj	in,in
R10572	T13385	T13387	amod	astrocytic,end-feet
R10573	T13386	T13387	amod	perivascular,end-feet
R10786	T13599	T13578	punct	.,observed
R10787	T13600	T13602	nsubj	SE,increases
R10854	T13667	T13678	det	a,infusion
R10865	T13678	T13681	nsubj	infusion,affect
R10866	T13679	T13681	aux	could,affect
R10867	T13680	T13681	neg	not,affect
R10868	T13681	T13681	ROOT	affect,affect
R10869	T13682	T13683	amod	leukocyte,infiltration
R10870	T13683	T13681	dobj	infiltration,affect
R10871	T13684	T13681	punct	.,affect
R10872	T13685	T13693	prep	In,inhibited
R10873	T13686	T13688	det	the,study
R10874	T13687	T13688	amod	present,study

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T14023	5400-5408	Positive_regulation	denotes	mediated
T14022	5400-5408	Positive_regulation	denotes	mediated
T14021	5427-5442	Phosphorylation	denotes	phosphorylation
T14020	5427-5442	Phosphorylation	denotes	phosphorylation
T14019	5424-5426	Protein	denotes	κB
T14018	5409-5423	Protein	denotes	p65-Thr 435 NF
T14017	5394-5399	Protein	denotes	TNF-α
T14016	5178-5183	Protein	denotes	TNF-α
T14015	4926-4934	Protein	denotes	sTNFp55R
T14014	4873-4879	Regulation	denotes	affect
T14013	4836-4841	Protein	denotes	IL-1β
T14012	4788-4801	Protein	denotes	P2X7 receptor
T14011	4717-4730	Protein	denotes	P2X7 receptor
T14010	4524-4529	Protein	denotes	MIP-2
T14009	4116-4121	Protein	denotes	IL-1β
T14008	4106-4111	Protein	denotes	TNF-α
T14007	3995-4010	Phosphorylation	denotes	phosphorylation
T14006	3904-3918	Phosphorylation	denotes	phosphorylated
T14005	3962-3967	Protein	denotes	IL-1β
T14004	3932-3937	Protein	denotes	IL-1β
T14003	3922-3927	Protein	denotes	TNF-α
T14002	3772-3780	Protein	denotes	sTNFp55R
T14001	3662-3670	Positive_regulation	denotes	enhanced
T14000	3662-3670	Positive_regulation	denotes	enhanced
T13999	3662-3670	Positive_regulation	denotes	enhanced
T13998	3662-3670	Positive_regulation	denotes	enhanced
T13997	3697-3712	Phosphorylation	denotes	phosphorylation
T13996	3697-3712	Phosphorylation	denotes	phosphorylation
T13995	3697-3712	Phosphorylation	denotes	phosphorylation
T13994	3697-3712	Phosphorylation	denotes	phosphorylation
T13993	3732-3737	Protein	denotes	TNF-α
T13992	3690-3696	Protein	denotes	Ser311
T13991	3686-3689	Protein	denotes	p65
T13990	3675-3681	Protein	denotes	Ser276
T13989	3671-3674	Protein	denotes	p65
T13988	3554-3563	Negative_regulation	denotes	inhibited
T13987	3554-3563	Negative_regulation	denotes	inhibited
T13986	3579-3604	Phosphorylation	denotes	p65-Ser311phosphorylation
T13985	3579-3604	Phosphorylation	denotes	p65-Ser311phosphorylation
T13984	3554-3563	Negative_regulation	denotes	inhibited
T13983	3568-3574	Protein	denotes	Ser276
T13982	3564-3567	Protein	denotes	p65
T13981	3524-3532	Protein	denotes	sTNFp55R
T13980	3454-3469	Phosphorylation	denotes	phosphorylation
T13979	3454-3469	Phosphorylation	denotes	phosphorylation
T13978	3447-3453	Protein	denotes	Ser536
T13977	3443-3446	Protein	denotes	p65
T13976	3095-3109	Negative_regulation	denotes	down-regulated
T13975	2977-2984	Binding	denotes	binding
T13974	2971-2976	Protein	denotes	actin
T13973	2956-2966	Protein	denotes	dystrophin
T13972	2722-2730	Positive_regulation	denotes	mediated
T13971	2722-2730	Positive_regulation	denotes	mediated
T13970	2742-2757	Phosphorylation	denotes	phosphorylation
T13969	2742-2757	Phosphorylation	denotes	phosphorylation
T13968	2644-2659	Phosphorylation	denotes	phosphorylation
T13967	2644-2659	Phosphorylation	denotes	phosphorylation
T13966	2735-2741	Protein	denotes	Thr435
T13965	2731-2734	Protein	denotes	p65
T13964	2716-2721	Protein	denotes	TNF-α
T13963	2677-2682	Protein	denotes	TNF-α
T13962	2667-2673	Protein	denotes	Thr435
T13961	2663-2666	Protein	denotes	p65
T13960	2549-2557	Protein	denotes	sTNFp55R
T13959	1585-1591	Positive_regulation	denotes	occurs
T13958	1569-1584	Phosphorylation	denotes	phosphorylation
T13957	1496-1511	Phosphorylation	denotes	phosphorylation
T13956	1496-1511	Phosphorylation	denotes	phosphorylation
T13955	1565-1568	Protein	denotes	p65
T13954	1515-1520	Protein	denotes	NF-κB
T13953	1492-1495	Protein	denotes	p65
T13952	1409-1414	Protein	denotes	TNF-α
T13951	1268-1275	Protein	denotes	sTNFp55
T13950	1158-1163	Protein	denotes	TNF-α
T13949	1015-1020	Protein	denotes	TNF-α
T13948	859-866	Protein	denotes	sTNFp55
T13947	840-845	Protein	denotes	TNF-α
T13946	733-745	Positive_regulation	denotes	up-regulated
T13945	733-745	Positive_regulation	denotes	up-regulated
T13944	733-745	Positive_regulation	denotes	up-regulated
T13943	711-722	Gene_expression	denotes	expressions
T13942	805-812	Protein	denotes	TNFp75R
T13941	773-780	Protein	denotes	TNFp75R
T13940	761-768	Protein	denotes	TNFp55R
T13939	698-710	Protein	denotes	TNF receptor
T13938	615-620	Protein	denotes	TNF-α
T13937	120-135	Phosphorylation	denotes	phosphorylation
T13936	114-119	Protein	denotes	NF-κB
T13935	60-65	Protein	denotes	TNF-α
R11046	T13958	T13959	themeOf	phosphorylation,occurs
R11047	T13936	T13937	themeOf	NF-κB,phosphorylation
R11048	T13961	T13967	themeOf	p65,phosphorylation
R11049	T13939	T13943	themeOf	TNF receptor,expressions
R11050	T13940	T13944	themeOf	TNFp55R,up-regulated
R11051	T13941	T13945	themeOf	TNFp75R,up-regulated
R11052	T13943	T13946	themeOf	expressions,up-regulated
R11053	T13962	T13968	themeOf	Thr435,phosphorylation
R11054	T13965	T13969	themeOf	p65,phosphorylation
R11055	T13966	T13970	themeOf	Thr435,phosphorylation
R11056	T13953	T13956	themeOf	p65,phosphorylation
R11057	T13969	T13971	themeOf	phosphorylation,mediated
R11058	T13954	T13957	themeOf	NF-κB,phosphorylation
R11059	T13955	T13958	themeOf	p65,phosphorylation
R11060	T13970	T13972	themeOf	phosphorylation,mediated
R11061	T13971	T13964	Cause	mediated,TNF-α
R11062	T13972	T13964	Cause	mediated,TNF-α
R11063	T13973	T13975	themeOf	dystrophin,binding
R11064	T13974	T13975	themeOf	actin,binding
R11065	T13975	T13976	themeOf	binding,down-regulated
R11066	T13977	T13979	themeOf	p65,phosphorylation
R11067	T13978	T13980	themeOf	Ser536,phosphorylation
R11068	T13982	T13985	themeOf	p65,p65-Ser311phosphorylation
R11069	T13983	T13984	themeOf	Ser276,inhibited
R11071	T13983	T13986	themeOf	Ser276,p65-Ser311phosphorylation
R11072	T13985	T13987	themeOf	p65-Ser311phosphorylation,inhibited
R11074	T13986	T13988	themeOf	p65-Ser311phosphorylation,inhibited
R11075	T13989	T13994	themeOf	p65,phosphorylation
R11077	T13990	T13995	themeOf	Ser276,phosphorylation
R11079	T13991	T13996	themeOf	p65,phosphorylation
R11085	T13992	T13997	themeOf	Ser311,phosphorylation
R11087	T13994	T13998	themeOf	phosphorylation,enhanced
R11089	T13995	T13999	themeOf	phosphorylation,enhanced
R11090	T13996	T14000	themeOf	phosphorylation,enhanced
R11094	T13997	T14001	themeOf	phosphorylation,enhanced
R11095	T14004	T14006	themeOf	IL-1β,phosphorylated
R11100	T14005	T14007	themeOf	IL-1β,phosphorylation
R11103	T14012	T14014	themeOf	P2X7 receptor,affect
R11107	T14018	T14020	themeOf	p65-Thr 435 NF,phosphorylation
R11110	T14019	T14021	themeOf	κB,phosphorylation
R11111	T14020	T14022	themeOf	phosphorylation,mediated
R11112	T14021	T14023	themeOf	phosphorylation,mediated
R11113	T14022	T14017	Cause	mediated,TNF-α
R11114	T14023	T14017	Cause	mediated,TNF-α

testone

Id	Subject	Object	Predicate	Lexical cue
T11407	3932-3937	Protein	denotes	IL-1β
T11406	3922-3927	Protein	denotes	TNF-α
T11405	3889-3892	Protein	denotes	p65
T11404	3874-3877	Protein	denotes	p65
T11403	3823-3826	Protein	denotes	p65
T11402	3808-3811	Protein	denotes	p65
T11401	3773-3780	Protein	denotes	TNFp55R
T11400	3732-3735	Protein	denotes	TNF
T11399	3686-3689	Protein	denotes	p65
T11398	3671-3674	Protein	denotes	p65
T11397	3579-3582	Protein	denotes	p65
T11396	3564-3567	Protein	denotes	p65
T11395	3525-3532	Protein	denotes	TNFp55R
T11394	3443-3446	Protein	denotes	p65
T11393	3427-3430	Protein	denotes	p65
T11392	3415-3418	Protein	denotes	p65
T11391	3403-3406	Protein	denotes	p65
T11390	2971-2992	Protein	denotes	actin-binding protein
T11389	2956-2966	Protein	denotes	dystrophin
T11388	2731-2734	Protein	denotes	p65
T11387	2716-2721	Protein	denotes	TNF-α
T11386	2677-2682	Protein	denotes	TNF-α
T11385	2663-2666	Protein	denotes	p65
T11384	2550-2557	Protein	denotes	TNFp55R
T11383	1659-1662	Protein	denotes	p65
T11382	1565-1568	Protein	denotes	p65
T11381	1492-1495	Protein	denotes	p65
T11380	1409-1414	Protein	denotes	TNF-α
T11379	1269-1275	Protein	denotes	TNFp55
T11378	1158-1163	Protein	denotes	TNF-α
T11377	1015-1020	Protein	denotes	TNF-α
T11376	860-866	Protein	denotes	TNFp55
T11375	840-845	Protein	denotes	TNF-α
T11374	805-812	Protein	denotes	TNFp75R
T11373	773-780	Protein	denotes	TNFp75R
T11372	761-768	Protein	denotes	TNFp55R
T11371	615-620	Protein	denotes	TNF-α
T11370	60-65	Protein	denotes	TNF-α
T11467	5427-5442	Phosphorylation	denotes	phosphorylation
T11466	5400-5408	Positive_regulation	denotes	mediated
T11465	5167-5174	Positive_regulation	denotes	induced
T11464	4842-4852	Negative_regulation	denotes	antagonist
T11463	4746-4756	Gene_expression	denotes	expression
T11462	4731-4739	Positive_regulation	denotes	mediated
T11461	3995-4010	Phosphorylation	denotes	phosphorylation
T11460	3988-3994	Entity	denotes	Ser536
T11459	3968-3976	Positive_regulation	denotes	mediated
T11458	3904-3918	Phosphorylation	denotes	phosphorylated
T11457	3893-3899	Entity	denotes	Ser536
T11456	3827-3833	Entity	denotes	Ser536
T11455	3800-3807	Negative_regulation	denotes	prevent
T11454	3751-3761	Negative_regulation	denotes	disruption
T11453	3738-3746	Positive_regulation	denotes	mediated
T11452	3720-3728	Regulation	denotes	involved
T11451	3697-3712	Phosphorylation	denotes	phosphorylation
T11450	3690-3696	Entity	denotes	Ser311
T11449	3675-3681	Entity	denotes	Ser276
T11448	3662-3670	Positive_regulation	denotes	enhanced
T11447	3619-3628	Positive_regulation	denotes	following
T11446	3568-3574	Entity	denotes	Ser276
T11445	3554-3563	Negative_regulation	denotes	inhibited
T11444	3497-3506	Positive_regulation	denotes	following
T11443	3454-3469	Phosphorylation	denotes	phosphorylation
T11442	3447-3453	Entity	denotes	Ser536
T11441	3407-3413	Entity	denotes	Ser276
T11440	3173-3188	Negative_regulation	denotes	down-regulation
T11439	2846-2857	Protein_catabolism	denotes	degradation
T11438	2825-2834	Positive_regulation	denotes	induction
T11437	2742-2757	Phosphorylation	denotes	phosphorylation
T11436	2722-2730	Positive_regulation	denotes	mediated
T11435	2644-2659	Phosphorylation	denotes	phosphorylation
T11434	2144-2158	Negative_regulation	denotes	neutralization
T11433	1966-1970	Negative_regulation	denotes	lost
T11432	1952-1962	Gene_expression	denotes	expression
T11431	1801-1811	Gene_expression	denotes	expression
T11430	1623-1630	Entity	denotes	nucleus
T11429	1569-1584	Phosphorylation	denotes	phosphorylation
T11428	1521-1529	Positive_regulation	denotes	enhances
T11427	1496-1511	Phosphorylation	denotes	phosphorylation
T11426	828-836	Negative_regulation	denotes	blockade
T11425	733-745	Positive_regulation	denotes	up-regulated
T11424	251-261	Negative_regulation	denotes	disruption
T11423	146-155	Positive_regulation	denotes	following
T11422	120-135	Phosphorylation	denotes	phosphorylation
T11421	5409-5412	Protein	denotes	p65
T11420	5394-5399	Protein	denotes	TNF-α
T11419	5178-5183	Protein	denotes	TNF-α
T11418	5043-5048	Protein	denotes	MIP-2
T11417	4927-4934	Protein	denotes	TNFp55R
T11416	4836-4852	Protein	denotes	IL-1β antagonist
T11415	4825-4831	Protein	denotes	IL-1Ra
T11414	4740-4745	Protein	denotes	MIP-2
T11413	4717-4730	Protein	denotes	P2X7 receptor
T11412	4524-4529	Protein	denotes	MIP-2
T11411	4116-4121	Protein	denotes	IL-1β
T11410	4106-4111	Protein	denotes	TNF-α
T11409	3977-3980	Protein	denotes	p65
T11408	3962-3967	Protein	denotes	IL-1β
R9036	T11372	T11425	causeOf	TNFp55R,up-regulated
R9037	T11373	T11425	causeOf	TNFp75R,up-regulated
R9038	T11374	T11425	causeOf	TNFp75R,up-regulated
R9039	T11381	T11427	themeOf	p65,phosphorylation
R9040	T11382	T11429	themeOf	p65,phosphorylation
R9041	T11385	T11435	themeOf	p65,phosphorylation
R9042	T11387	T11436	causeOf	TNF-α,mediated
R9043	T11388	T11437	themeOf	p65,phosphorylation
R9044	T11391	T11443	themeOf	p65,phosphorylation
R9045	T11392	T11443	themeOf	p65,phosphorylation
R9046	T11393	T11443	themeOf	p65,phosphorylation
R9047	T11394	T11443	themeOf	p65,phosphorylation
R9048	T11398	T11451	themeOf	p65,phosphorylation
R9049	T11399	T11451	themeOf	p65,phosphorylation
R9050	T11404	T11458	themeOf	p65,phosphorylated
R9051	T11405	T11458	themeOf	p65,phosphorylated
R9052	T11406	T11458	causeOf	TNF-α,phosphorylated
R9053	T11407	T11458	causeOf	IL-1β,phosphorylated
R9054	T11408	T11459	causeOf	IL-1β,mediated
R9055	T11409	T11461	themeOf	p65,phosphorylation
R9056	T11413	T11462	causeOf	P2X7 receptor,mediated
R9057	T11414	T11463	themeOf	MIP-2,expression
R9058	T11415	T11464	themeOf	IL-1Ra,antagonist
R9059	T11416	T11415	equivalentTo	IL-1β antagonist,IL-1Ra
R9060	T11419	T11465	causeOf	TNF-α,induced
R9061	T11420	T11466	causeOf	TNF-α,mediated
R9062	T11421	T11467	themeOf	p65,phosphorylation
R9063	T11427	T11428	causeOf	phosphorylation,enhances
R9064	T11429	T11428	themeOf	phosphorylation,enhances
R9065	T11432	T11433	themeOf	expression,lost
R9066	T11437	T11436	themeOf	phosphorylation,mediated
R9067	T11441	T11391	partOf	Ser276,p65
R9068	T11441	T11443	themeOf	Ser276,phosphorylation
R9069	T11442	T11392	partOf	Ser536,p65
R9070	T11442	T11443	themeOf	Ser536,phosphorylation
R9071	T11442	T11391	partOf	Ser536,p65
R9072	T11442	T11394	partOf	Ser536,p65
R9073	T11442	T11393	partOf	Ser536,p65
R9074	T11443	T11444	themeOf	phosphorylation,following
R9075	T11446	T11396	partOf	Ser276,p65
R9076	T11449	T11398	partOf	Ser276,p65
R9077	T11449	T11451	themeOf	Ser276,phosphorylation
R9078	T11450	T11399	partOf	Ser311,p65
R9079	T11450	T11398	partOf	Ser311,p65
R9080	T11450	T11451	themeOf	Ser311,phosphorylation
R9081	T11451	T11448	themeOf	phosphorylation,enhanced
R9082	T11454	T11453	themeOf	disruption,mediated
R9083	T11456	T11403	partOf	Ser536,p65
R9084	T11456	T11402	partOf	Ser536,p65
R9085	T11457	T11458	themeOf	Ser536,phosphorylated
R9086	T11457	T11405	partOf	Ser536,p65
R9087	T11457	T11404	partOf	Ser536,p65
R9088	T11460	T11409	partOf	Ser536,p65
R9089	T11460	T11461	themeOf	Ser536,phosphorylation
R9090	T11461	T11459	themeOf	phosphorylation,mediated
R9091	T11463	T11462	themeOf	expression,mediated
R9092	T11467	T11466	themeOf	phosphorylation,mediated

test3

Id	Subject	Object	Predicate	Lexical cue
T11610	5427-5442	Phosphorylation	denotes	phosphorylation
T11609	5409-5412	Protein	denotes	p65
T11608	5400-5408	Positive_regulation	denotes	mediated
T11607	5394-5399	Protein	denotes	TNF-α
T11606	5178-5183	Protein	denotes	TNF-α
T11605	5167-5174	Positive_regulation	denotes	induced
T11604	5043-5048	Protein	denotes	MIP-2
T11603	4926-4934	Protein	denotes	sTNFp55R
T11602	4836-4852	Protein	denotes	IL-1β antagonist
T11601	4825-4831	Protein	denotes	IL-1Ra
T11600	4746-4756	Gene_expression	denotes	expression
T11599	4740-4745	Protein	denotes	MIP-2
T11598	4731-4739	Positive_regulation	denotes	mediated
T11597	4717-4730	Protein	denotes	P2X7 receptor
T11596	4704-4713	Regulation	denotes	regulated
T11595	4524-4529	Protein	denotes	MIP-2
T11594	4116-4121	Protein	denotes	IL-1β
T11593	4106-4111	Protein	denotes	TNF-α
T11592	3995-4010	Phosphorylation	denotes	phosphorylation
T11591	3988-3994	Entity	denotes	Ser536
T11590	3977-3980	Protein	denotes	p65
T11589	3968-3976	Positive_regulation	denotes	mediated
T11588	3962-3967	Protein	denotes	IL-1β
T11587	3932-3937	Protein	denotes	IL-1β
T11586	3922-3927	Protein	denotes	TNF-α
T11585	3904-3918	Phosphorylation	denotes	phosphorylated
T11584	3893-3899	Entity	denotes	Ser536
T11583	3889-3892	Protein	denotes	p65
T11582	3874-3877	Protein	denotes	p65
T11581	3827-3833	Entity	denotes	Ser536
T11580	3823-3826	Protein	denotes	p65
T11579	3808-3811	Protein	denotes	p65
T11578	3800-3807	Negative_regulation	denotes	prevent
T11577	3772-3780	Protein	denotes	sTNFp55R
T11576	3751-3761	Negative_regulation	denotes	disruption
T11575	3738-3746	Positive_regulation	denotes	mediated
T11574	3732-3735	Protein	denotes	TNF
T11573	3720-3728	Regulation	denotes	involved
T11572	3697-3712	Phosphorylation	denotes	phosphorylation
T11571	3690-3696	Entity	denotes	Ser311
T11570	3686-3689	Protein	denotes	p65
T11569	3675-3681	Entity	denotes	Ser276
T11568	3671-3674	Protein	denotes	p65
T11567	3662-3670	Positive_regulation	denotes	enhanced
T11566	3619-3628	Positive_regulation	denotes	following
T11565	3583-3604	Phosphorylation	denotes	Ser311phosphorylation
T11564	3579-3582	Protein	denotes	p65
T11563	3568-3574	Entity	denotes	Ser276
T11562	3564-3567	Protein	denotes	p65
T11561	3554-3563	Negative_regulation	denotes	inhibited
T11560	3524-3532	Protein	denotes	sTNFp55R
T11559	3497-3506	Positive_regulation	denotes	following
T11558	3454-3469	Phosphorylation	denotes	phosphorylation
T11557	3447-3453	Entity	denotes	Ser536
T11556	3443-3446	Protein	denotes	p65
T11555	3427-3430	Protein	denotes	p65
T11554	3415-3418	Protein	denotes	p65
T11553	3407-3413	Entity	denotes	Ser276
T11552	3403-3406	Protein	denotes	p65
T11551	3095-3109	Negative_regulation	denotes	down-regulated
T11550	2971-2992	Protein	denotes	actin-binding protein
T11549	2956-2966	Protein	denotes	dystrophin
T11548	2742-2757	Phosphorylation	denotes	phosphorylation
T11547	2731-2734	Protein	denotes	p65
T11546	2722-2730	Positive_regulation	denotes	mediated
T11545	2716-2721	Protein	denotes	TNF-α
T11544	2677-2682	Protein	denotes	TNF-α
T11543	2663-2666	Protein	denotes	p65
T11542	2644-2659	Phosphorylation	denotes	phosphorylation
T11541	2549-2557	Protein	denotes	sTNFp55R
T11540	1952-1962	Gene_expression	denotes	expression
T11539	1801-1811	Gene_expression	denotes	expression
T11538	1659-1662	Protein	denotes	p65
T11537	1623-1630	Entity	denotes	nucleus
T11536	1569-1584	Phosphorylation	denotes	phosphorylation
T11535	1565-1568	Protein	denotes	p65
T11534	1496-1511	Phosphorylation	denotes	phosphorylation
T11533	1492-1495	Protein	denotes	p65
T11532	1409-1414	Protein	denotes	TNF-α
T11531	1268-1275	Protein	denotes	sTNFp55
T11530	1158-1163	Protein	denotes	TNF-α
T11529	1015-1020	Protein	denotes	TNF-α
T11528	859-866	Protein	denotes	sTNFp55
T11527	840-845	Protein	denotes	TNF-α
T11526	828-836	Negative_regulation	denotes	blockade
T11525	805-812	Protein	denotes	TNFp75R
T11524	773-780	Protein	denotes	TNFp75R
T11523	761-768	Protein	denotes	TNFp55R
T11522	615-620	Protein	denotes	TNF-α
T11521	120-135	Phosphorylation	denotes	phosphorylation
T11520	60-65	Protein	denotes	TNF-α
T11519	5409-5412	Protein	denotes	p65
T11518	5394-5399	Protein	denotes	TNF-α
T11517	5178-5183	Protein	denotes	TNF-α
T11516	5043-5048	Protein	denotes	MIP-2
T11515	4927-4934	Protein	denotes	TNFp55R
T11514	4836-4852	Protein	denotes	IL-1β antagonist
T11513	4825-4831	Protein	denotes	IL-1Ra
T11512	4740-4745	Protein	denotes	MIP-2
T11511	4717-4730	Protein	denotes	P2X7 receptor
T11510	4524-4529	Protein	denotes	MIP-2
T11509	4116-4121	Protein	denotes	IL-1β
T11508	4106-4111	Protein	denotes	TNF-α
T11507	3977-3980	Protein	denotes	p65
T11506	3962-3967	Protein	denotes	IL-1β
T11505	3932-3937	Protein	denotes	IL-1β
T11504	3922-3927	Protein	denotes	TNF-α
T11503	3889-3892	Protein	denotes	p65
T11502	3874-3877	Protein	denotes	p65
T11501	3823-3826	Protein	denotes	p65
T11500	3808-3811	Protein	denotes	p65
T11499	3773-3780	Protein	denotes	TNFp55R
T11498	3732-3735	Protein	denotes	TNF
T11497	3686-3689	Protein	denotes	p65
T11496	3671-3674	Protein	denotes	p65
T11495	3579-3582	Protein	denotes	p65
T11494	3564-3567	Protein	denotes	p65
T11493	3525-3532	Protein	denotes	TNFp55R
T11492	3443-3446	Protein	denotes	p65
T11491	3427-3430	Protein	denotes	p65
T11490	3415-3418	Protein	denotes	p65
T11489	3403-3406	Protein	denotes	p65
T11488	2971-2992	Protein	denotes	actin-binding protein
T11487	2956-2966	Protein	denotes	dystrophin
T11486	2731-2734	Protein	denotes	p65
T11485	2716-2721	Protein	denotes	TNF-α
T11484	2677-2682	Protein	denotes	TNF-α
T11483	2663-2666	Protein	denotes	p65
T11482	2550-2557	Protein	denotes	TNFp55R
T11481	1659-1662	Protein	denotes	p65
T11480	1565-1568	Protein	denotes	p65
T11479	1492-1495	Protein	denotes	p65
T11478	1409-1414	Protein	denotes	TNF-α
T11477	1269-1275	Protein	denotes	TNFp55
T11476	1158-1163	Protein	denotes	TNF-α
T11475	1015-1020	Protein	denotes	TNF-α
T11474	860-866	Protein	denotes	TNFp55
T11473	840-845	Protein	denotes	TNF-α
T11472	805-812	Protein	denotes	TNFp75R
T11471	773-780	Protein	denotes	TNFp75R
T11470	761-768	Protein	denotes	TNFp55R
T11469	615-620	Protein	denotes	TNF-α
T11468	60-65	Protein	denotes	TNF-α
R9093	T11528	T11526	causeOf	sTNFp55,blockade
R9094	T11533	T11534	themeOf	p65,phosphorylation
R9095	T11535	T11536	themeOf	p65,phosphorylation
R9096	T11543	T11542	themeOf	p65,phosphorylation
R9097	T11545	T11546	causeOf	TNF-α,mediated
R9098	T11547	T11548	themeOf	p65,phosphorylation
R9099	T11548	T11546	themeOf	phosphorylation,mediated
R9100	T11549	T11551	themeOf	dystrophin,down-regulated
R9101	T11550	T11551	themeOf	actin-binding protein,down-regulated
R9102	T11552	T11558	themeOf	p65,phosphorylation
R9103	T11553	T11552	partOf	Ser276,p65
R9104	T11553	T11558	themeOf	Ser276,phosphorylation
R9105	T11554	T11558	themeOf	p65,phosphorylation
R9106	T11555	T11558	themeOf	p65,phosphorylation
R9107	T11556	T11558	themeOf	p65,phosphorylation
R9108	T11557	T11558	themeOf	Ser536,phosphorylation
R9109	T11557	T11556	partOf	Ser536,p65
R9110	T11558	T11559	themeOf	phosphorylation,following
R9111	T11560	T11561	causeOf	sTNFp55R,inhibited
R9112	T11562	T11565	themeOf	p65,Ser311phosphorylation
R9113	T11563	T11565	themeOf	Ser276,Ser311phosphorylation
R9114	T11563	T11561	themeOf	Ser276,inhibited
R9115	T11563	T11562	partOf	Ser276,p65
R9116	T11564	T11565	themeOf	p65,Ser311phosphorylation
R9117	T11565	T11561	themeOf	Ser311phosphorylation,inhibited
R9118	T11565	T11566	themeOf	Ser311phosphorylation,following
R9119	T11568	T11572	themeOf	p65,phosphorylation
R9120	T11569	T11572	themeOf	Ser276,phosphorylation
R9121	T11569	T11568	partOf	Ser276,p65
R9122	T11570	T11572	themeOf	p65,phosphorylation
R9123	T11571	T11572	themeOf	Ser311,phosphorylation
R9124	T11572	T11567	themeOf	phosphorylation,enhanced
R9125	T11572	T11573	causeOf	phosphorylation,involved
R9126	T11576	T11575	themeOf	disruption,mediated
R9127	T11577	T11578	causeOf	sTNFp55R,prevent
R9128	T11581	T11580	partOf	Ser536,p65
R9129	T11581	T11579	partOf	Ser536,p65
R9130	T11582	T11585	themeOf	p65,phosphorylated
R9131	T11584	T11583	partOf	Ser536,p65
R9132	T11584	T11585	themeOf	Ser536,phosphorylated
R9133	T11586	T11585	causeOf	TNF-α,phosphorylated
R9134	T11587	T11585	causeOf	IL-1β,phosphorylated
R9135	T11588	T11589	causeOf	IL-1β,mediated
R9136	T11590	T11592	themeOf	p65,phosphorylation
R9137	T11591	T11590	partOf	Ser536,p65
R9138	T11591	T11592	themeOf	Ser536,phosphorylation
R9139	T11592	T11589	themeOf	phosphorylation,mediated
R9140	T11599	T11600	themeOf	MIP-2,expression
R9141	T11600	T11598	themeOf	expression,mediated
R9142	T11606	T11605	causeOf	TNF-α,induced
R9143	T11607	T11608	causeOf	TNF-α,mediated
R9144	T11609	T11610	themeOf	p65,phosphorylation
R9145	T11610	T11608	themeOf	phosphorylation,mediated

PMC:3312845 / 28471-34035 JSONTXT

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