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2_test

{"project":"2_test","denotations":[{"id":"22240205-1337917-63147433","span":{"begin":130,"end":132},"obj":"1337917"},{"id":"22240205-20939924-63147434","span":{"begin":234,"end":236},"obj":"20939924"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

pmc-enju-pas

bionlp-st-ge-2016-test-proteins

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T16307","span":{"begin":2156,"end":2161},"obj":"Protein"},{"id":"T16306","span":{"begin":2051,"end":2058},"obj":"Protein"},{"id":"T16305","span":{"begin":1988,"end":1993},"obj":"Protein"},{"id":"T16304","span":{"begin":1859,"end":1864},"obj":"Protein"},{"id":"T16303","span":{"begin":1459,"end":1464},"obj":"Protein"},{"id":"T16302","span":{"begin":1387,"end":1392},"obj":"Protein"},{"id":"T16301","span":{"begin":1282,"end":1287},"obj":"Protein"},{"id":"T16300","span":{"begin":1234,"end":1241},"obj":"Protein"},{"id":"T9896","span":{"begin":1171,"end":1176},"obj":"Protein"},{"id":"T9895","span":{"begin":859,"end":866},"obj":"Protein"},{"id":"T9894","span":{"begin":632,"end":639},"obj":"Protein"},{"id":"T9893","span":{"begin":413,"end":420},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

bionlp-st-ge-2016-uniprot

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T10102","span":{"begin":1171,"end":1176},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T16516","span":{"begin":2156,"end":2161},"obj":"http://www.uniprot.org/uniprot/P10889"},{"id":"T16515","span":{"begin":1988,"end":1993},"obj":"http://www.uniprot.org/uniprot/P10889"},{"id":"T16514","span":{"begin":1859,"end":1864},"obj":"http://www.uniprot.org/uniprot/P10889"},{"id":"T16513","span":{"begin":1459,"end":1464},"obj":"http://www.uniprot.org/uniprot/P10889"},{"id":"T16512","span":{"begin":1387,"end":1392},"obj":"http://www.uniprot.org/uniprot/P10889"},{"id":"T16511","span":{"begin":1282,"end":1287},"obj":"http://www.uniprot.org/uniprot/P10889"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"T9879","span":{"begin":85,"end":90},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

GO-BP

{"project":"GO-BP","denotations":[{"id":"T9898","span":{"begin":1202,"end":1211},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T9897","span":{"begin":334,"end":337},"obj":"http://purl.obolibrary.org/obo/GO_0004601"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

GO-MF

{"project":"GO-MF","denotations":[{"id":"T9899","span":{"begin":334,"end":337},"obj":"http://purl.obolibrary.org/obo/GO_0004601"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

GO-CC

{"project":"GO-CC","denotations":[{"id":"T16310","span":{"begin":2171,"end":2176},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16309","span":{"begin":2003,"end":2008},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16308","span":{"begin":1874,"end":1879},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

sentences

simple1

{"project":"simple1","denotations":[{"id":"T16318","span":{"begin":2156,"end":2161},"obj":"Protein"},{"id":"T16317","span":{"begin":2051,"end":2058},"obj":"Protein"},{"id":"T16316","span":{"begin":1988,"end":1993},"obj":"Protein"},{"id":"T16315","span":{"begin":1859,"end":1864},"obj":"Protein"},{"id":"T16314","span":{"begin":1459,"end":1464},"obj":"Protein"},{"id":"T16313","span":{"begin":1387,"end":1392},"obj":"Protein"},{"id":"T16312","span":{"begin":1282,"end":1287},"obj":"Protein"},{"id":"T16311","span":{"begin":1234,"end":1241},"obj":"Protein"},{"id":"T9903","span":{"begin":1171,"end":1176},"obj":"Protein"},{"id":"T9902","span":{"begin":859,"end":866},"obj":"Protein"},{"id":"T9901","span":{"begin":632,"end":639},"obj":"Protein"},{"id":"T9900","span":{"begin":413,"end":420},"obj":"Protein"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

BioNLP16_DUT

{"project":"BioNLP16_DUT","denotations":[{"id":"T16779","span":{"begin":1282,"end":1287},"obj":"Protein"},{"id":"T16790","span":{"begin":1994,"end":2002},"obj":"Gene_expression"},{"id":"T16789","span":{"begin":1445,"end":1455},"obj":"Gene_expression"},{"id":"T16788","span":{"begin":1393,"end":1403},"obj":"Gene_expression"},{"id":"T16787","span":{"begin":1288,"end":1298},"obj":"Gene_expression"},{"id":"T16786","span":{"begin":1223,"end":1229},"obj":"Regulation"},{"id":"T16785","span":{"begin":2156,"end":2161},"obj":"Protein"},{"id":"T16784","span":{"begin":2051,"end":2058},"obj":"Protein"},{"id":"T16783","span":{"begin":1988,"end":1993},"obj":"Protein"},{"id":"T16782","span":{"begin":1859,"end":1864},"obj":"Protein"},{"id":"T16781","span":{"begin":1459,"end":1464},"obj":"Protein"},{"id":"T16780","span":{"begin":1387,"end":1392},"obj":"Protein"},{"id":"T10340","span":{"begin":1171,"end":1176},"obj":"Protein"},{"id":"T10339","span":{"begin":859,"end":866},"obj":"Protein"},{"id":"T10338","span":{"begin":632,"end":639},"obj":"Protein"},{"id":"T10337","span":{"begin":413,"end":420},"obj":"Protein"},{"id":"T16778","span":{"begin":1234,"end":1241},"obj":"Protein"}],"relations":[{"id":"R12817","pred":"themeOf","subj":"T16778","obj":"T16786"},{"id":"R12818","pred":"themeOf","subj":"T16779","obj":"T16787"},{"id":"R12819","pred":"themeOf","subj":"T16780","obj":"T16788"},{"id":"R12820","pred":"themeOf","subj":"T16781","obj":"T16789"},{"id":"R12821","pred":"themeOf","subj":"T16783","obj":"T16790"},{"id":"R12822","pred":"themeOf","subj":"T16787","obj":"T16786"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

BioNLP16_Messiy

{"project":"BioNLP16_Messiy","denotations":[{"id":"T16733","span":{"begin":1994,"end":2002},"obj":"Gene_expression"},{"id":"T16732","span":{"begin":1445,"end":1455},"obj":"Gene_expression"},{"id":"T16731","span":{"begin":1393,"end":1403},"obj":"Gene_expression"},{"id":"T16730","span":{"begin":1223,"end":1229},"obj":"Regulation"},{"id":"T16729","span":{"begin":1288,"end":1298},"obj":"Gene_expression"},{"id":"T16728","span":{"begin":2156,"end":2161},"obj":"Protein"},{"id":"T16727","span":{"begin":2051,"end":2058},"obj":"Protein"},{"id":"T16726","span":{"begin":1988,"end":1993},"obj":"Protein"},{"id":"T16725","span":{"begin":1859,"end":1864},"obj":"Protein"},{"id":"T16724","span":{"begin":1459,"end":1464},"obj":"Protein"},{"id":"T16723","span":{"begin":1387,"end":1392},"obj":"Protein"},{"id":"T16722","span":{"begin":1282,"end":1287},"obj":"Protein"},{"id":"T16721","span":{"begin":1234,"end":1241},"obj":"Protein"},{"id":"T10313","span":{"begin":1171,"end":1176},"obj":"Protein"},{"id":"T10312","span":{"begin":859,"end":866},"obj":"Protein"},{"id":"T10311","span":{"begin":632,"end":639},"obj":"Protein"},{"id":"T10310","span":{"begin":413,"end":420},"obj":"Protein"}],"relations":[{"id":"R12797","pred":"themeOf","subj":"T16722","obj":"T16729"},{"id":"R12798","pred":"themeOf","subj":"T16723","obj":"T16731"},{"id":"R12799","pred":"themeOf","subj":"T16724","obj":"T16732"},{"id":"R12800","pred":"themeOf","subj":"T16726","obj":"T16733"},{"id":"R12801","pred":"themeOf","subj":"T16729","obj":"T16730"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

DLUT931

bionlp-st-ge-2016-test-ihmc

bionlp-st-ge-2016-spacy-parsed

bionlp-st-ge-2016-test-tees

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T16772","span":{"begin":2050,"end":2058},"obj":"Protein"},{"id":"T16771","span":{"begin":1393,"end":1403},"obj":"Gene_expression"},{"id":"T16770","span":{"begin":1411,"end":1415},"obj":"Protein"},{"id":"T16769","span":{"begin":1223,"end":1229},"obj":"Regulation"},{"id":"T16768","span":{"begin":1233,"end":1241},"obj":"Protein"},{"id":"T10329","span":{"begin":1171,"end":1176},"obj":"Protein"},{"id":"T10328","span":{"begin":858,"end":866},"obj":"Protein"},{"id":"T10327","span":{"begin":631,"end":639},"obj":"Protein"},{"id":"T10326","span":{"begin":475,"end":479},"obj":"Protein"},{"id":"T10325","span":{"begin":412,"end":420},"obj":"Protein"},{"id":"T10324","span":{"begin":334,"end":337},"obj":"Protein"},{"id":"T10323","span":{"begin":215,"end":219},"obj":"Protein"}],"relations":[{"id":"R12813","pred":"themeOf","subj":"T16768","obj":"T16769"},{"id":"R12814","pred":"themeOf","subj":"T16770","obj":"T16771"}],"text":"Neutrophil infiltration\nRecent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26]. Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20]. In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC. Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A). The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p \u003c 0.05). However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D). Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p \u003c 0.05, Figure 6E). Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.\nFigure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows). Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M). Significant differences from saline-infused animals, *p \u003c 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M). There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC."}

testone

test3

PMC:3312845 / 24633-26892 JSONTXT

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PMC:3312845 / 24633-26892 JSON TXT