PMC:3312845 / 19411-20962 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3312845","sourcedb":"PMC","sourceid":"3312845","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3312845","text":"Effect of sTNFp55R infusion on SE-induced serum-protein extravasation and neuronal damage\nIn our previous [5,7,8,20] and preliminary data, vasogenic edema and neuronal damage were noticeable at 1 day and 3 days after SE, respectively. Therefore, we determined that 3 days after SE was the best time point to evaluate the effect of sTNFp55R infusion on both vasogenic edema and neuronal damages induced by SE. In saline-treated animals, the PC was stained diffusely with anti-rat IgG (Figure 2A). The volume of vasogenic edema was 17.1 ± 1.5 mm3 (Figure 2E). The number of FJB-positive neurons in the PC was 236,145 ± 49,469 (Figure 2B). In sTNFp55R-treated animals, SE-induced vasogenic edema was attenuated to 9.8 ± 0.7 mm3 (Figures 2C and 2E). In addition, the number of FJB-positive neurons in the PC was 89,138 ± 5,698 (Figures 2D-E). Thus, sTNFp55R infusion attenuated SE-induced vasogenic edema and neuronal damage compared to saline-infused animals (p \u003c 0.05).\nFigure 2 Effect of sTNFp55R infusion on SE-induced serum-protein extravasation and neuronal damage. (A-D) Serum-protein extravasation and FJB-positive neuronal damages in the PC 3 days after SE. Compared to saline-infused animals, serum-protein extravasation and FJB-positive neuronal damage is markedly ameliorated in sTNFp55R-infused animals. Bars = 400 (A and C) and 50 (B and D) μm. (E) Quantitative analyses of serum-protein extravasation and FJB-positive neuronal damage in the PC 3 days after SE (mean ± S.E.M). Significant differences from saline-treated animals, *p \u003c 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