PMC:3291650 / 17692-18922 JSON TXT

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test3

{"project":"test3","denotations":[{"id":"T8667","span":{"begin":1093,"end":1097},"obj":"Negative_regulation"},{"id":"T8666","span":{"begin":29,"end":39},"obj":"Gene_expression"},{"id":"T8665","span":{"begin":17,"end":21},"obj":"Regulation"}],"relations":[{"id":"R6102","pred":"themeOf","subj":"T8666","obj":"T8665"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

pmc-enju-pas

bionlp-st-ge-2016-uniprot

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T11118","span":{"begin":1101,"end":1104},"obj":"http://www.uniprot.org/uniprot/P21580"},{"id":"T11117","span":{"begin":25,"end":28},"obj":"http://www.uniprot.org/uniprot/P21580"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"T8710","span":{"begin":484,"end":488},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

GO-BP

{"project":"GO-BP","denotations":[{"id":"T8815","span":{"begin":1144,"end":1161},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T8814","span":{"begin":1144,"end":1161},"obj":"http://purl.obolibrary.org/obo/GO_0019058"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

GO-CC

{"project":"GO-CC","denotations":[{"id":"T8865","span":{"begin":1116,"end":1121},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T8864","span":{"begin":51,"end":56},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

sentences

{"project":"sentences","denotations":[{"id":"T8727","span":{"begin":1073,"end":1230},"obj":"Sentence"},{"id":"T8726","span":{"begin":871,"end":1072},"obj":"Sentence"},{"id":"T8725","span":{"begin":754,"end":870},"obj":"Sentence"},{"id":"T8724","span":{"begin":677,"end":753},"obj":"Sentence"},{"id":"T8723","span":{"begin":421,"end":676},"obj":"Sentence"},{"id":"T8722","span":{"begin":277,"end":420},"obj":"Sentence"},{"id":"T8721","span":{"begin":0,"end":276},"obj":"Sentence"},{"id":"T111","span":{"begin":0,"end":276},"obj":"Sentence"},{"id":"T112","span":{"begin":277,"end":420},"obj":"Sentence"},{"id":"T113","span":{"begin":421,"end":676},"obj":"Sentence"},{"id":"T114","span":{"begin":677,"end":753},"obj":"Sentence"},{"id":"T115","span":{"begin":754,"end":870},"obj":"Sentence"},{"id":"T116","span":{"begin":871,"end":1072},"obj":"Sentence"},{"id":"T117","span":{"begin":1073,"end":1230},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

bionlp-st-ge-2016-test-ihmc

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T11422","span":{"begin":25,"end":28},"obj":"Protein"},{"id":"T11408","span":{"begin":122,"end":137},"obj":"Protein"},{"id":"T11402","span":{"begin":458,"end":468},"obj":"Entity"},{"id":"T11501","span":{"begin":22,"end":39},"obj":"Gene_expression"},{"id":"T11498","span":{"begin":835,"end":839},"obj":"Protein"},{"id":"T11494","span":{"begin":458,"end":461},"obj":"Protein"},{"id":"T11492","span":{"begin":1098,"end":1104},"obj":"Protein"},{"id":"T11491","span":{"begin":1108,"end":1121},"obj":"Entity"},{"id":"T11484","span":{"begin":1038,"end":1071},"obj":"Protein"},{"id":"T11482","span":{"begin":802,"end":817},"obj":"Protein"},{"id":"T11478","span":{"begin":643,"end":675},"obj":"Protein"},{"id":"T11475","span":{"begin":433,"end":468},"obj":"Protein"},{"id":"T11469","span":{"begin":956,"end":960},"obj":"Protein"},{"id":"T11468","span":{"begin":215,"end":219},"obj":"Entity"},{"id":"T11457","span":{"begin":600,"end":615},"obj":"Protein"},{"id":"T11449","span":{"begin":43,"end":56},"obj":"Entity"},{"id":"T11443","span":{"begin":288,"end":292},"obj":"Protein"}],"relations":[{"id":"R8459","pred":"themeOf","subj":"T11422","obj":"T11501"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

bionlp-st-ge-2016-spacy-parsed

bionlp-st-ge-2016-test-tees

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T11240","span":{"begin":17,"end":21},"obj":"Regulation"},{"id":"T11239","span":{"begin":29,"end":39},"obj":"Gene_expression"},{"id":"T11238","span":{"begin":25,"end":28},"obj":"Protein"}],"relations":[{"id":"R8398","pred":"themeOf","subj":"T11238","obj":"T11239"},{"id":"R8399","pred":"themeOf","subj":"T11239","obj":"T11240"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

testone

{"project":"testone","denotations":[{"id":"T8621","span":{"begin":1093,"end":1097},"obj":"Negative_regulation"},{"id":"T8620","span":{"begin":315,"end":319},"obj":"Negative_regulation"},{"id":"T8619","span":{"begin":29,"end":39},"obj":"Gene_expression"},{"id":"T8618","span":{"begin":17,"end":21},"obj":"Regulation"}],"relations":[{"id":"R6095","pred":"themeOf","subj":"T8619","obj":"T8618"}],"text":"To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss. A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A). Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown). Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection. No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection. However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B). This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection."}

PMC:3291650 / 17692-18922 JSONTXT

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PMC:3291650 / 17692-18922 JSON TXT