PMC:3291650 / 1604-2856 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3291650","sourcedb":"PMC","sourceid":"3291650","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3291650","text":"Influenza virus or flu epidemics represent a recurrent threat to the public health, especially for individuals which are part of a high-risk group such as children, elderly or immune-compromised people. Sporadic pandemic flu outbreaks, such as the Spanish flu of 1918, may cause high grades of mortality among healthy persons. A better understanding of how the immune system deals with these pathogens is of key importance. The protein A20 is an important negative regulator of both innate and adaptive immune responses. We show that the specific deletion of A20 in myeloid cells, such as macrophages and neutrophils, improves the resistance against otherwise lethal influenza infections. This protective effect is mediated by an enhanced innate immune response following respiratory challenge with influenza virus. Although exaggerated pulmonary immune responses are believed to be the primary cause of often life threatening influenza virus induced pneumonia, we demonstrate that boosting the innate immune response by selectively targeting the functionality of A20 in myeloid cells is beneficial for the host survival. This finding provides us with a novel valuable approach for treating influenza and potentially other respiratory viral infections.","tracks":[{"project":"sentences","denotations":[{"id":"T13","span":{"begin":0,"end":202},"obj":"Sentence"},{"id":"T14","span":{"begin":203,"end":326},"obj":"Sentence"},{"id":"T15","span":{"begin":327,"end":423},"obj":"Sentence"},{"id":"T16","span":{"begin":424,"end":520},"obj":"Sentence"},{"id":"T17","span":{"begin":521,"end":688},"obj":"Sentence"},{"id":"T18","span":{"begin":689,"end":815},"obj":"Sentence"},{"id":"T19","span":{"begin":816,"end":1121},"obj":"Sentence"},{"id":"T20","span":{"begin":1122,"end":1252},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"},{"subj":"T16","pred":"source","obj":"sentences"},{"subj":"T17","pred":"source","obj":"sentences"},{"subj":"T18","pred":"source","obj":"sentences"},{"subj":"T19","pred":"source","obj":"sentences"},{"subj":"T20","pred":"source","obj":"sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#93eccc","default":true}]}]}}