PMC:3291650 / 1604-2856 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T13	0-202	Sentence	denotes	Influenza virus or flu epidemics represent a recurrent threat to the public health, especially for individuals which are part of a high-risk group such as children, elderly or immune-compromised people.
T14	203-326	Sentence	denotes	Sporadic pandemic flu outbreaks, such as the Spanish flu of 1918, may cause high grades of mortality among healthy persons.
T15	327-423	Sentence	denotes	A better understanding of how the immune system deals with these pathogens is of key importance.
T16	424-520	Sentence	denotes	The protein A20 is an important negative regulator of both innate and adaptive immune responses.
T17	521-688	Sentence	denotes	We show that the specific deletion of A20 in myeloid cells, such as macrophages and neutrophils, improves the resistance against otherwise lethal influenza infections.
T18	689-815	Sentence	denotes	This protective effect is mediated by an enhanced innate immune response following respiratory challenge with influenza virus.
T19	816-1121	Sentence	denotes	Although exaggerated pulmonary immune responses are believed to be the primary cause of often life threatening influenza virus induced pneumonia, we demonstrate that boosting the innate immune response by selectively targeting the functionality of A20 in myeloid cells is beneficial for the host survival.
T20	1122-1252	Sentence	denotes	This finding provides us with a novel valuable approach for treating influenza and potentially other respiratory viral infections.