PMC:3291650 / 15270-15831
Annnotations
test3
{"project":"test3","denotations":[{"id":"T7681","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T7680","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T7679","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T7678","span":{"begin":348,"end":352},"obj":"Protein"},{"id":"T7677","span":{"begin":334,"end":344},"obj":"Gene_expression"},{"id":"T7676","span":{"begin":325,"end":333},"obj":"Positive_regulation"},{"id":"T7675","span":{"begin":241,"end":250},"obj":"Negative_regulation"},{"id":"T7674","span":{"begin":121,"end":130},"obj":"Negative_regulation"},{"id":"T7663","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T7662","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T7661","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T7660","span":{"begin":348,"end":352},"obj":"Protein"}],"relations":[{"id":"R5394","pred":"themeOf","subj":"T7677","obj":"T7676"},{"id":"R5395","pred":"themeOf","subj":"T7678","obj":"T7677"},{"id":"R5396","pred":"themeOf","subj":"T7679","obj":"T7677"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
pmc-enju-pas
{"project":"pmc-enju-pas","denotations":[{"id":"T7918","span":{"begin":559,"end":560},"obj":"-RRB-"},{"id":"T7917","span":{"begin":557,"end":559},"obj":"NN"},{"id":"T7916","span":{"begin":550,"end":556},"obj":"NN"},{"id":"T7915","span":{"begin":549,"end":550},"obj":"-LRB-"},{"id":"T7914","span":{"begin":544,"end":548},"obj":"NN"},{"id":"T7913","span":{"begin":540,"end":543},"obj":"CC"},{"id":"T7912","span":{"begin":536,"end":539},"obj":"NN"},{"id":"T7911","span":{"begin":533,"end":535},"obj":"IN"},{"id":"T7910","span":{"begin":526,"end":532},"obj":"NN"},{"id":"T7909","span":{"begin":519,"end":525},"obj":"JJ"},{"id":"T7908","span":{"begin":509,"end":518},"obj":"VB"},{"id":"T7907","span":{"begin":503,"end":508},"obj":"NN"},{"id":"T7906","span":{"begin":497,"end":502},"obj":"DT"},{"id":"T7905","span":{"begin":492,"end":496},"obj":"IN"},{"id":"T7904","span":{"begin":482,"end":491},"obj":"VB"},{"id":"T7903","span":{"begin":470,"end":481},"obj":"NN"},{"id":"T7902","span":{"begin":462,"end":469},"obj":"NN"},{"id":"T7901","span":{"begin":457,"end":461},"obj":"NN"},{"id":"T7900","span":{"begin":455,"end":456},"obj":"-COMMA-"},{"id":"T7899","span":{"begin":451,"end":455},"obj":"NN"},{"id":"T7898","span":{"begin":445,"end":450},"obj":"DT"},{"id":"T7897","span":{"begin":440,"end":444},"obj":"IN"},{"id":"T7896","span":{"begin":429,"end":439},"obj":"NN"},{"id":"T7895","span":{"begin":426,"end":428},"obj":"IN"},{"id":"T7894","span":{"begin":423,"end":424},"obj":"-RRB-"},{"id":"T7893","span":{"begin":421,"end":423},"obj":"NN"},{"id":"T7892","span":{"begin":414,"end":420},"obj":"NN"},{"id":"T7891","span":{"begin":413,"end":414},"obj":"-LRB-"},{"id":"T7890","span":{"begin":407,"end":412},"obj":"NN"},{"id":"T7889","span":{"begin":399,"end":406},"obj":"NN"},{"id":"T7888","span":{"begin":396,"end":398},"obj":"TO"},{"id":"T7887","span":{"begin":387,"end":395},"obj":"VB"},{"id":"T7886","span":{"begin":377,"end":386},"obj":"NN"},{"id":"T7885","span":{"begin":373,"end":376},"obj":"NN"},{"id":"T7884","span":{"begin":367,"end":372},"obj":"IN"},{"id":"T7883","span":{"begin":362,"end":366},"obj":"NN"},{"id":"T7882","span":{"begin":357,"end":361},"obj":"NN"},{"id":"T7881","span":{"begin":353,"end":356},"obj":"CC"},{"id":"T7880","span":{"begin":348,"end":352},"obj":"NN"},{"id":"T7879","span":{"begin":345,"end":347},"obj":"IN"},{"id":"T7878","span":{"begin":334,"end":344},"obj":"NN"},{"id":"T7877","span":{"begin":325,"end":333},"obj":"VB"},{"id":"T7876","span":{"begin":320,"end":324},"obj":"VB"},{"id":"T7875","span":{"begin":315,"end":319},"obj":"NN"},{"id":"T7874","span":{"begin":304,"end":314},"obj":"NN"},{"id":"T7873","span":{"begin":302,"end":303},"obj":"-COMMA-"},{"id":"T7872","span":{"begin":291,"end":302},"obj":"RB"},{"id":"T7871","span":{"begin":288,"end":289},"obj":"-RRB-"},{"id":"T7870","span":{"begin":286,"end":288},"obj":"NN"},{"id":"T7869","span":{"begin":279,"end":285},"obj":"NN"},{"id":"T7868","span":{"begin":278,"end":279},"obj":"-LRB-"},{"id":"T7867","span":{"begin":268,"end":277},"obj":"NN"},{"id":"T7866","span":{"begin":262,"end":267},"obj":"JJ"},{"id":"T7865","span":{"begin":257,"end":261},"obj":"IN"},{"id":"T7864","span":{"begin":255,"end":256},"obj":"-COMMA-"},{"id":"T7863","span":{"begin":251,"end":255},"obj":"NN"},{"id":"T7862","span":{"begin":241,"end":250},"obj":"JJ"},{"id":"T7861","span":{"begin":237,"end":240},"obj":"NN"},{"id":"T7860","span":{"begin":234,"end":236},"obj":"IN"},{"id":"T7859","span":{"begin":230,"end":233},"obj":"RB"},{"id":"T7858","span":{"begin":226,"end":229},"obj":"CC"},{"id":"T7857","span":{"begin":224,"end":225},"obj":"-COMMA-"},{"id":"T7856","span":{"begin":220,"end":224},"obj":"NN"},{"id":"T7855","span":{"begin":215,"end":219},"obj":"NN"},{"id":"T7854","span":{"begin":210,"end":214},"obj":"JJ"},{"id":"T7853","span":{"begin":207,"end":209},"obj":"IN"},{"id":"T7852","span":{"begin":199,"end":206},"obj":"VB"},{"id":"T7851","span":{"begin":191,"end":198},"obj":"RB"},{"id":"T7850","span":{"begin":186,"end":190},"obj":"VB"},{"id":"T7849","span":{"begin":179,"end":185},"obj":"NN"},{"id":"T7848","span":{"begin":174,"end":178},"obj":"NN"},{"id":"T7847","span":{"begin":170,"end":173},"obj":"NN"},{"id":"T7846","span":{"begin":167,"end":168},"obj":"-RRB-"},{"id":"T7845","span":{"begin":163,"end":167},"obj":"NN"},{"id":"T7844","span":{"begin":162,"end":163},"obj":"-LRB-"},{"id":"T7843","span":{"begin":157,"end":161},"obj":"NN"},{"id":"T7842","span":{"begin":153,"end":156},"obj":"NN"},{"id":"T7841","span":{"begin":148,"end":152},"obj":"IN"},{"id":"T7840","span":{"begin":143,"end":147},"obj":"NN"},{"id":"T7839","span":{"begin":135,"end":142},"obj":"NN"},{"id":"T7838","span":{"begin":131,"end":134},"obj":"CC"},{"id":"T7837","span":{"begin":121,"end":130},"obj":"JJ"},{"id":"T7836","span":{"begin":117,"end":120},"obj":"NN"},{"id":"T7835","span":{"begin":108,"end":116},"obj":"VB"},{"id":"T7834","span":{"begin":105,"end":107},"obj":"PRP"},{"id":"T7833","span":{"begin":103,"end":104},"obj":"-COMMA-"},{"id":"T7832","span":{"begin":94,"end":103},"obj":"NN"},{"id":"T7831","span":{"begin":87,"end":93},"obj":"JJ"},{"id":"T7830","span":{"begin":80,"end":86},"obj":"JJ"},{"id":"T7829","span":{"begin":70,"end":79},"obj":"JJ"},{"id":"T7828","span":{"begin":66,"end":69},"obj":"CC"},{"id":"T7827","span":{"begin":50,"end":65},"obj":"JJ"},{"id":"T7826","span":{"begin":38,"end":49},"obj":"JJ"},{"id":"T7825","span":{"begin":34,"end":37},"obj":"DT"},{"id":"T7824","span":{"begin":31,"end":33},"obj":"IN"},{"id":"T7823","span":{"begin":27,"end":30},"obj":"NN"},{"id":"T7822","span":{"begin":24,"end":26},"obj":"IN"},{"id":"T7821","span":{"begin":19,"end":23},"obj":"NN"},{"id":"T7820","span":{"begin":15,"end":18},"obj":"DT"},{"id":"T7819","span":{"begin":3,"end":14},"obj":"VB"},{"id":"T7818","span":{"begin":0,"end":2},"obj":"TO"}],"relations":[{"id":"R5456","pred":"arg1Of","subj":"T7819","obj":"T7818"},{"id":"R5457","pred":"arg2Of","subj":"T7821","obj":"T7819"},{"id":"R5458","pred":"arg1Of","subj":"T7821","obj":"T7820"},{"id":"R5459","pred":"arg1Of","subj":"T7821","obj":"T7822"},{"id":"R5460","pred":"arg1Of","subj":"T7821","obj":"T7824"},{"id":"R5461","pred":"arg2Of","subj":"T7823","obj":"T7822"},{"id":"R5462","pred":"arg1Of","subj":"T7827","obj":"T7826"},{"id":"R5463","pred":"arg1Of","subj":"T7827","obj":"T7828"},{"id":"R5464","pred":"arg2Of","subj":"T7831","obj":"T7828"},{"id":"R5465","pred":"arg1Of","subj":"T7831","obj":"T7829"},{"id":"R5466","pred":"arg1Of","subj":"T7831","obj":"T7830"},{"id":"R5467","pred":"arg2Of","subj":"T7832","obj":"T7824"},{"id":"R5468","pred":"arg1Of","subj":"T7832","obj":"T7825"},{"id":"R5469","pred":"arg1Of","subj":"T7832","obj":"T7827"},{"id":"R5470","pred":"arg1Of","subj":"T7832","obj":"T7831"},{"id":"R5471","pred":"arg1Of","subj":"T7834","obj":"T7819"},{"id":"R5472","pred":"arg1Of","subj":"T7834","obj":"T7835"},{"id":"R5473","pred":"modOf","subj":"T7835","obj":"T7818"},{"id":"R5474","pred":"arg1Of","subj":"T7835","obj":"T7833"},{"id":"R5475","pred":"arg1Of","subj":"T7836","obj":"T7837"},{"id":"R5476","pred":"arg1Of","subj":"T7836","obj":"T7838"},{"id":"R5477","pred":"arg2Of","subj":"T7838","obj":"T7835"},{"id":"R5478","pred":"arg1Of","subj":"T7838","obj":"T7841"},{"id":"R5479","pred":"arg2Of","subj":"T7840","obj":"T7838"},{"id":"R5480","pred":"arg1Of","subj":"T7840","obj":"T7839"},{"id":"R5481","pred":"arg2Of","subj":"T7843","obj":"T7841"},{"id":"R5482","pred":"arg1Of","subj":"T7843","obj":"T7842"},{"id":"R5483","pred":"arg1Of","subj":"T7843","obj":"T7844"},{"id":"R5484","pred":"arg2Of","subj":"T7845","obj":"T7844"},{"id":"R5485","pred":"arg3Of","subj":"T7846","obj":"T7844"},{"id":"R5486","pred":"arg1Of","subj":"T7849","obj":"T7847"},{"id":"R5487","pred":"arg1Of","subj":"T7849","obj":"T7848"},{"id":"R5488","pred":"arg1Of","subj":"T7849","obj":"T7850"},{"id":"R5489","pred":"arg2Of","subj":"T7849","obj":"T7852"},{"id":"R5490","pred":"arg2Of","subj":"T7852","obj":"T7850"},{"id":"R5491","pred":"arg1Of","subj":"T7852","obj":"T7851"},{"id":"R5492","pred":"arg1Of","subj":"T7852","obj":"T7853"},{"id":"R5493","pred":"arg1Of","subj":"T7852","obj":"T7860"},{"id":"R5494","pred":"arg1Of","subj":"T7852","obj":"T7864"},{"id":"R5495","pred":"arg1Of","subj":"T7852","obj":"T7865"},{"id":"R5496","pred":"arg1Of","subj":"T7853","obj":"T7858"},{"id":"R5497","pred":"arg2Of","subj":"T7856","obj":"T7853"},{"id":"R5498","pred":"arg1Of","subj":"T7856","obj":"T7854"},{"id":"R5499","pred":"arg1Of","subj":"T7856","obj":"T7855"},{"id":"R5500","pred":"arg1Of","subj":"T7858","obj":"T7857"},{"id":"R5501","pred":"arg2Of","subj":"T7860","obj":"T7858"},{"id":"R5502","pred":"arg1Of","subj":"T7860","obj":"T7859"},{"id":"R5503","pred":"arg2Of","subj":"T7863","obj":"T7860"},{"id":"R5504","pred":"arg1Of","subj":"T7863","obj":"T7861"},{"id":"R5505","pred":"arg1Of","subj":"T7863","obj":"T7862"},{"id":"R5506","pred":"arg2Of","subj":"T7867","obj":"T7865"},{"id":"R5507","pred":"arg1Of","subj":"T7867","obj":"T7866"},{"id":"R5508","pred":"arg1Of","subj":"T7867","obj":"T7868"},{"id":"R5509","pred":"arg2Of","subj":"T7870","obj":"T7868"},{"id":"R5510","pred":"arg1Of","subj":"T7870","obj":"T7869"},{"id":"R5511","pred":"arg3Of","subj":"T7871","obj":"T7868"},{"id":"R5512","pred":"arg1Of","subj":"T7875","obj":"T7874"},{"id":"R5513","pred":"arg1Of","subj":"T7875","obj":"T7876"},{"id":"R5514","pred":"arg1Of","subj":"T7876","obj":"T7872"},{"id":"R5515","pred":"arg1Of","subj":"T7876","obj":"T7873"},{"id":"R5516","pred":"arg1Of","subj":"T7876","obj":"T7887"},{"id":"R5517","pred":"arg2Of","subj":"T7878","obj":"T7876"},{"id":"R5518","pred":"arg2Of","subj":"T7878","obj":"T7877"},{"id":"R5519","pred":"arg1Of","subj":"T7878","obj":"T7879"},{"id":"R5520","pred":"arg1Of","subj":"T7878","obj":"T7884"},{"id":"R5521","pred":"arg1Of","subj":"T7880","obj":"T7881"},{"id":"R5522","pred":"arg2Of","subj":"T7882","obj":"T7881"},{"id":"R5523","pred":"arg2Of","subj":"T7883","obj":"T7879"},{"id":"R5524","pred":"arg1Of","subj":"T7883","obj":"T7880"},{"id":"R5525","pred":"arg1Of","subj":"T7883","obj":"T7882"},{"id":"R5526","pred":"arg2Of","subj":"T7886","obj":"T7884"},{"id":"R5527","pred":"arg1Of","subj":"T7886","obj":"T7885"},{"id":"R5528","pred":"arg2Of","subj":"T7888","obj":"T7887"},{"id":"R5529","pred":"arg2Of","subj":"T7890","obj":"T7888"},{"id":"R5530","pred":"arg1Of","subj":"T7890","obj":"T7889"},{"id":"R5531","pred":"arg1Of","subj":"T7890","obj":"T7891"},{"id":"R5532","pred":"arg2Of","subj":"T7893","obj":"T7891"},{"id":"R5533","pred":"arg1Of","subj":"T7893","obj":"T7892"},{"id":"R5534","pred":"arg3Of","subj":"T7894","obj":"T7891"},{"id":"R5535","pred":"arg2Of","subj":"T7896","obj":"T7895"},{"id":"R5536","pred":"arg1Of","subj":"T7896","obj":"T7897"},{"id":"R5537","pred":"arg2Of","subj":"T7899","obj":"T7897"},{"id":"R5538","pred":"arg1Of","subj":"T7899","obj":"T7898"},{"id":"R5539","pred":"arg1Of","subj":"T7903","obj":"T7901"},{"id":"R5540","pred":"arg1Of","subj":"T7903","obj":"T7902"},{"id":"R5541","pred":"arg2Of","subj":"T7903","obj":"T7904"},{"id":"R5542","pred":"arg1Of","subj":"T7903","obj":"T7908"},{"id":"R5543","pred":"arg1Of","subj":"T7904","obj":"T7905"},{"id":"R5544","pred":"arg2Of","subj":"T7907","obj":"T7905"},{"id":"R5545","pred":"arg1Of","subj":"T7907","obj":"T7906"},{"id":"R5546","pred":"arg1Of","subj":"T7908","obj":"T7895"},{"id":"R5547","pred":"arg1Of","subj":"T7908","obj":"T7900"},{"id":"R5548","pred":"arg2Of","subj":"T7910","obj":"T7908"},{"id":"R5549","pred":"arg1Of","subj":"T7910","obj":"T7909"},{"id":"R5550","pred":"arg1Of","subj":"T7910","obj":"T7911"},{"id":"R5551","pred":"arg1Of","subj":"T7912","obj":"T7913"},{"id":"R5552","pred":"arg2Of","subj":"T7913","obj":"T7911"},{"id":"R5553","pred":"arg1Of","subj":"T7913","obj":"T7915"},{"id":"R5554","pred":"arg2Of","subj":"T7914","obj":"T7913"},{"id":"R5555","pred":"arg2Of","subj":"T7917","obj":"T7915"},{"id":"R5556","pred":"arg1Of","subj":"T7917","obj":"T7916"},{"id":"R5557","pred":"arg3Of","subj":"T7918","obj":"T7915"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T7757","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T7756","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T7755","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T7754","span":{"begin":348,"end":352},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T8353","span":{"begin":536,"end":539},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8351","span":{"begin":348,"end":352},"obj":"http://www.uniprot.org/uniprot/P05231"},{"id":"T8346","span":{"begin":237,"end":240},"obj":"http://www.uniprot.org/uniprot/P21580"},{"id":"T8345","span":{"begin":170,"end":173},"obj":"http://www.uniprot.org/uniprot/P21580"},{"id":"T8344","span":{"begin":117,"end":120},"obj":"http://www.uniprot.org/uniprot/P21580"},{"id":"T8343","span":{"begin":27,"end":30},"obj":"http://www.uniprot.org/uniprot/P21580"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T7779","span":{"begin":262,"end":277},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T7778","span":{"begin":87,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T7777","span":{"begin":80,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0045824"},{"id":"T7776","span":{"begin":80,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0045089"},{"id":"T7775","span":{"begin":80,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0002218"},{"id":"T7774","span":{"begin":80,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0045088"},{"id":"T7773","span":{"begin":80,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0002227"},{"id":"T7772","span":{"begin":80,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T7771","span":{"begin":80,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0045087"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T7786","span":{"begin":348,"end":352},"obj":"http://purl.obolibrary.org/obo/GO_0005138"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T7790","span":{"begin":503,"end":508},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7789","span":{"begin":407,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
sentences
{"project":"sentences","denotations":[{"id":"T7702","span":{"begin":426,"end":561},"obj":"Sentence"},{"id":"T7701","span":{"begin":291,"end":425},"obj":"Sentence"},{"id":"T7700","span":{"begin":170,"end":290},"obj":"Sentence"},{"id":"T7699","span":{"begin":0,"end":169},"obj":"Sentence"},{"id":"T94","span":{"begin":0,"end":169},"obj":"Sentence"},{"id":"T95","span":{"begin":170,"end":290},"obj":"Sentence"},{"id":"T96","span":{"begin":291,"end":425},"obj":"Sentence"},{"id":"T97","span":{"begin":426,"end":561},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
ICD10
{"project":"ICD10","denotations":[{"id":"T7785","span":{"begin":262,"end":277},"obj":"http://purl.bioontology.org/ontology/ICD10/B34.9"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
simple1
{"project":"simple1","denotations":[{"id":"T7799","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T7798","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T7797","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T7796","span":{"begin":348,"end":352},"obj":"Protein"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T8505","span":{"begin":526,"end":532},"obj":"Positive_regulation"},{"id":"T8504","span":{"begin":325,"end":333},"obj":"Positive_regulation"},{"id":"T8503","span":{"begin":334,"end":344},"obj":"Gene_expression"},{"id":"T8492","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T8491","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T8490","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T8489","span":{"begin":348,"end":352},"obj":"Protein"}],"relations":[{"id":"R6052","pred":"themeOf","subj":"T8489","obj":"T8503"},{"id":"R6053","pred":"themeOf","subj":"T8490","obj":"T8503"},{"id":"R6054","pred":"themeOf","subj":"T8491","obj":"T8505"},{"id":"R6073","pred":"themeOf","subj":"T8503","obj":"T8504"},{"id":"R6074","pred":"themeOf","subj":"T8503","obj":"T8504"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T8371","span":{"begin":325,"end":333},"obj":"Positive_regulation"},{"id":"T8370","span":{"begin":334,"end":344},"obj":"Gene_expression"},{"id":"T8359","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T8358","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T8357","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T8356","span":{"begin":348,"end":352},"obj":"Protein"}],"relations":[{"id":"R5969","pred":"themeOf","subj":"T8356","obj":"T8370"},{"id":"R5970","pred":"themeOf","subj":"T8357","obj":"T8370"},{"id":"R5984","pred":"themeOf","subj":"T8370","obj":"T8371"},{"id":"R5985","pred":"themeOf","subj":"T8370","obj":"T8371"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T8391","span":{"begin":519,"end":525},"obj":"Positive_regulation"},{"id":"T8390","span":{"begin":325,"end":333},"obj":"Positive_regulation"},{"id":"T8389","span":{"begin":334,"end":344},"obj":"Gene_expression"},{"id":"T8378","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T8377","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T8376","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T8375","span":{"begin":348,"end":352},"obj":"Protein"}],"relations":[{"id":"R5986","pred":"themeOf","subj":"T8375","obj":"T8389"},{"id":"R5987","pred":"themeOf","subj":"T8376","obj":"T8389"},{"id":"R5988","pred":"themeOf","subj":"T8377","obj":"T8391"},{"id":"R5989","pred":"themeOf","subj":"T8378","obj":"T8391"},{"id":"R6005","pred":"themeOf","subj":"T8389","obj":"T8390"},{"id":"R6006","pred":"themeOf","subj":"T8389","obj":"T8390"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T8527","span":{"begin":70,"end":104},"obj":"Entity"},{"id":"T8520","span":{"begin":237,"end":250},"obj":"Protein"},{"id":"T8519","span":{"begin":396,"end":424},"obj":"Entity"},{"id":"T8516","span":{"begin":117,"end":130},"obj":"Protein"},{"id":"T8510","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T8557","span":{"begin":334,"end":366},"obj":"Gene_expression"},{"id":"T8556","span":{"begin":334,"end":366},"obj":"Gene_expression"},{"id":"T8550","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T8545","span":{"begin":170,"end":173},"obj":"Protein"},{"id":"T8543","span":{"begin":544,"end":560},"obj":"Protein"},{"id":"T8539","span":{"begin":24,"end":49},"obj":"Protein"},{"id":"T8538","span":{"begin":497,"end":508},"obj":"Entity"},{"id":"T8536","span":{"begin":357,"end":366},"obj":"Protein"},{"id":"T8532","span":{"begin":348,"end":352},"obj":"Protein"},{"id":"T8530","span":{"begin":163,"end":167},"obj":"Entity"}],"relations":[{"id":"R6080","pred":"themeOf","subj":"T8532","obj":"T8557"},{"id":"R6082","pred":"themeOf","subj":"T8536","obj":"T8556"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
bionlp-st-ge-2016-spacy-parsed
{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T8191","span":{"begin":560,"end":561},"obj":"."},{"id":"T8190","span":{"begin":559,"end":560},"obj":"-RRB-"},{"id":"T8189","span":{"begin":557,"end":559},"obj":"NN"},{"id":"T8188","span":{"begin":550,"end":556},"obj":"NN"},{"id":"T8187","span":{"begin":549,"end":550},"obj":"-LRB-"},{"id":"T8186","span":{"begin":544,"end":548},"obj":"NNP"},{"id":"T8185","span":{"begin":540,"end":543},"obj":"CC"},{"id":"T8184","span":{"begin":536,"end":539},"obj":"NNP"},{"id":"T8183","span":{"begin":533,"end":535},"obj":"IN"},{"id":"T8182","span":{"begin":526,"end":532},"obj":"NNS"},{"id":"T8181","span":{"begin":519,"end":525},"obj":"JJR"},{"id":"T8180","span":{"begin":509,"end":518},"obj":"VBD"},{"id":"T8179","span":{"begin":503,"end":508},"obj":"NNS"},{"id":"T8178","span":{"begin":497,"end":502},"obj":"DT"},{"id":"T8177","span":{"begin":492,"end":496},"obj":"IN"},{"id":"T8176","span":{"begin":482,"end":491},"obj":"VBN"},{"id":"T8175","span":{"begin":470,"end":481},"obj":"JJ"},{"id":"T8174","span":{"begin":462,"end":469},"obj":"NN"},{"id":"T8173","span":{"begin":457,"end":461},"obj":"NN"},{"id":"T8172","span":{"begin":455,"end":456},"obj":","},{"id":"T8171","span":{"begin":451,"end":455},"obj":"NNS"},{"id":"T8170","span":{"begin":445,"end":450},"obj":"DT"},{"id":"T8169","span":{"begin":440,"end":444},"obj":"IN"},{"id":"T8168","span":{"begin":429,"end":439},"obj":"NN"},{"id":"T8167","span":{"begin":426,"end":428},"obj":"IN"},{"id":"T8166","span":{"begin":424,"end":425},"obj":"."},{"id":"T8165","span":{"begin":423,"end":424},"obj":"-RRB-"},{"id":"T8164","span":{"begin":421,"end":423},"obj":"NN"},{"id":"T8163","span":{"begin":414,"end":420},"obj":"NN"},{"id":"T8162","span":{"begin":413,"end":414},"obj":"-LRB-"},{"id":"T8161","span":{"begin":407,"end":412},"obj":"NNS"},{"id":"T8160","span":{"begin":399,"end":406},"obj":"VB"},{"id":"T8159","span":{"begin":396,"end":398},"obj":"TO"},{"id":"T8158","span":{"begin":387,"end":395},"obj":"VBN"},{"id":"T8157","span":{"begin":377,"end":386},"obj":"NN"},{"id":"T8156","span":{"begin":373,"end":376},"obj":"NNP"},{"id":"T8155","span":{"begin":367,"end":372},"obj":"IN"},{"id":"T8154","span":{"begin":362,"end":366},"obj":"NNP"},{"id":"T8153","span":{"begin":357,"end":361},"obj":"NNP"},{"id":"T8152","span":{"begin":353,"end":356},"obj":"CC"},{"id":"T8151","span":{"begin":348,"end":352},"obj":"NNP"},{"id":"T8150","span":{"begin":345,"end":347},"obj":"IN"},{"id":"T8149","span":{"begin":334,"end":344},"obj":"NN"},{"id":"T8148","span":{"begin":325,"end":333},"obj":"JJ"},{"id":"T8147","span":{"begin":320,"end":324},"obj":"NN"},{"id":"T8146","span":{"begin":315,"end":319},"obj":"NNP"},{"id":"T8145","span":{"begin":304,"end":314},"obj":"JJ"},{"id":"T8144","span":{"begin":302,"end":303},"obj":","},{"id":"T8143","span":{"begin":291,"end":302},"obj":"RB"},{"id":"T8142","span":{"begin":289,"end":290},"obj":"."},{"id":"T8141","span":{"begin":288,"end":289},"obj":"-RRB-"},{"id":"T8140","span":{"begin":286,"end":288},"obj":"NN"},{"id":"T8139","span":{"begin":279,"end":285},"obj":"NN"},{"id":"T8138","span":{"begin":278,"end":279},"obj":"-LRB-"},{"id":"T8137","span":{"begin":268,"end":277},"obj":"NN"},{"id":"T8136","span":{"begin":262,"end":267},"obj":"JJ"},{"id":"T8135","span":{"begin":257,"end":261},"obj":"IN"},{"id":"T8134","span":{"begin":255,"end":256},"obj":","},{"id":"T8133","span":{"begin":251,"end":255},"obj":"NNP"},{"id":"T8132","span":{"begin":241,"end":250},"obj":"JJ"},{"id":"T8131","span":{"begin":237,"end":240},"obj":"CD"},{"id":"T8130","span":{"begin":234,"end":236},"obj":"IN"},{"id":"T8129","span":{"begin":230,"end":233},"obj":"RB"},{"id":"T8128","span":{"begin":226,"end":229},"obj":"CC"},{"id":"T8127","span":{"begin":224,"end":225},"obj":","},{"id":"T8126","span":{"begin":220,"end":224},"obj":"NNP"},{"id":"T8125","span":{"begin":215,"end":219},"obj":"NN"},{"id":"T8124","span":{"begin":210,"end":214},"obj":"JJ"},{"id":"T8123","span":{"begin":207,"end":209},"obj":"IN"},{"id":"T8122","span":{"begin":199,"end":206},"obj":"VBN"},{"id":"T8121","span":{"begin":191,"end":198},"obj":"RB"},{"id":"T8120","span":{"begin":186,"end":190},"obj":"VBD"},{"id":"T8119","span":{"begin":179,"end":185},"obj":"NNS"},{"id":"T8118","span":{"begin":174,"end":178},"obj":"NNP"},{"id":"T8117","span":{"begin":170,"end":173},"obj":"CD"},{"id":"T8116","span":{"begin":168,"end":169},"obj":"."},{"id":"T8115","span":{"begin":167,"end":168},"obj":"-RRB-"},{"id":"T8114","span":{"begin":163,"end":167},"obj":"NNP"},{"id":"T8113","span":{"begin":162,"end":163},"obj":"-LRB-"},{"id":"T8112","span":{"begin":157,"end":161},"obj":"NNP"},{"id":"T8111","span":{"begin":153,"end":156},"obj":"NNP"},{"id":"T8110","span":{"begin":148,"end":152},"obj":"IN"},{"id":"T8109","span":{"begin":143,"end":147},"obj":"NNP"},{"id":"T8108","span":{"begin":135,"end":142},"obj":"NN"},{"id":"T8107","span":{"begin":131,"end":134},"obj":"CC"},{"id":"T8106","span":{"begin":121,"end":130},"obj":"NN"},{"id":"T8105","span":{"begin":117,"end":120},"obj":"NNP"},{"id":"T8104","span":{"begin":108,"end":116},"obj":"VBD"},{"id":"T8103","span":{"begin":105,"end":107},"obj":"PRP"},{"id":"T8102","span":{"begin":103,"end":104},"obj":","},{"id":"T8101","span":{"begin":94,"end":103},"obj":"NNS"},{"id":"T8100","span":{"begin":87,"end":93},"obj":"JJ"},{"id":"T8099","span":{"begin":80,"end":86},"obj":"NN"},{"id":"T8098","span":{"begin":70,"end":79},"obj":"JJ"},{"id":"T8097","span":{"begin":66,"end":69},"obj":"CC"},{"id":"T8096","span":{"begin":50,"end":65},"obj":"JJ"},{"id":"T8095","span":{"begin":38,"end":49},"obj":"JJ"},{"id":"T8094","span":{"begin":34,"end":37},"obj":"DT"},{"id":"T8093","span":{"begin":31,"end":33},"obj":"IN"},{"id":"T8092","span":{"begin":27,"end":30},"obj":"NNP"},{"id":"T8091","span":{"begin":24,"end":26},"obj":"IN"},{"id":"T8090","span":{"begin":19,"end":23},"obj":"NN"},{"id":"T8089","span":{"begin":15,"end":18},"obj":"DT"},{"id":"T8088","span":{"begin":3,"end":14},"obj":"VB"},{"id":"T8087","span":{"begin":0,"end":2},"obj":"TO"}],"relations":[{"id":"R5714","pred":"aux","subj":"T8087","obj":"T8088"},{"id":"R5716","pred":"det","subj":"T8089","obj":"T8090"},{"id":"R5717","pred":"dobj","subj":"T8090","obj":"T8088"},{"id":"R5718","pred":"prep","subj":"T8091","obj":"T8090"},{"id":"R5719","pred":"pobj","subj":"T8092","obj":"T8091"},{"id":"R5720","pred":"prep","subj":"T8093","obj":"T8090"},{"id":"R5721","pred":"det","subj":"T8094","obj":"T8101"},{"id":"R5722","pred":"amod","subj":"T8095","obj":"T8101"},{"id":"R5723","pred":"conj","subj":"T8096","obj":"T8095"},{"id":"R5724","pred":"cc","subj":"T8097","obj":"T8096"},{"id":"R5725","pred":"conj","subj":"T8098","obj":"T8096"},{"id":"R5726","pred":"amod","subj":"T8099","obj":"T8101"},{"id":"R5727","pred":"amod","subj":"T8100","obj":"T8101"},{"id":"R5728","pred":"pobj","subj":"T8101","obj":"T8093"},{"id":"R5729","pred":"punct","subj":"T8102","obj":"T8104"},{"id":"R5730","pred":"nsubj","subj":"T8103","obj":"T8104"},{"id":"R5731","pred":"ROOT","subj":"T8104","obj":"T8104"},{"id":"R5732","pred":"compound","subj":"T8105","obj":"T8106"},{"id":"R5733","pred":"nmod","subj":"T8106","obj":"T8109"},{"id":"R5734","pred":"cc","subj":"T8107","obj":"T8106"},{"id":"R5735","pred":"conj","subj":"T8108","obj":"T8106"},{"id":"R5736","pred":"dobj","subj":"T8109","obj":"T8104"},{"id":"R5737","pred":"prep","subj":"T8110","obj":"T8104"},{"id":"R5738","pred":"compound","subj":"T8111","obj":"T8112"},{"id":"R5739","pred":"pobj","subj":"T8112","obj":"T8110"},{"id":"R5740","pred":"punct","subj":"T8113","obj":"T8112"},{"id":"R5741","pred":"appos","subj":"T8114","obj":"T8112"},{"id":"R5742","pred":"punct","subj":"T8115","obj":"T8112"},{"id":"R5743","pred":"punct","subj":"T8116","obj":"T8104"},{"id":"R5744","pred":"nummod","subj":"T8117","obj":"T8119"},{"id":"R5745","pred":"compound","subj":"T8118","obj":"T8119"},{"id":"R5746","pred":"nsubjpass","subj":"T8119","obj":"T8122"},{"id":"R5747","pred":"auxpass","subj":"T8120","obj":"T8122"},{"id":"R5748","pred":"advmod","subj":"T8121","obj":"T8122"},{"id":"R5749","pred":"ROOT","subj":"T8122","obj":"T8122"},{"id":"R5750","pred":"prep","subj":"T8123","obj":"T8122"},{"id":"R5751","pred":"amod","subj":"T8124","obj":"T8125"},{"id":"R5752","pred":"compound","subj":"T8125","obj":"T8126"},{"id":"R5753","pred":"pobj","subj":"T8126","obj":"T8123"},{"id":"R5754","pred":"punct","subj":"T8127","obj":"T8122"},{"id":"R5755","pred":"cc","subj":"T8128","obj":"T8122"},{"id":"R5756","pred":"neg","subj":"T8129","obj":"T8130"},{"id":"R5757","pred":"conj","subj":"T8130","obj":"T8122"},{"id":"R5758","pred":"pobj","subj":"T8131","obj":"T8130"},{"id":"R5759","pred":"amod","subj":"T8132","obj":"T8133"},{"id":"R5760","pred":"conj","subj":"T8133","obj":"T8130"},{"id":"R5761","pred":"punct","subj":"T8134","obj":"T8135"},{"id":"R5762","pred":"prep","subj":"T8135","obj":"T8133"},{"id":"R5763","pred":"amod","subj":"T8136","obj":"T8137"},{"id":"R5764","pred":"pobj","subj":"T8137","obj":"T8135"},{"id":"R5765","pred":"punct","subj":"T8138","obj":"T8140"},{"id":"R5766","pred":"compound","subj":"T8139","obj":"T8140"},{"id":"R5767","pred":"appos","subj":"T8140","obj":"T8137"},{"id":"R5768","pred":"punct","subj":"T8141","obj":"T8140"},{"id":"R5769","pred":"punct","subj":"T8142","obj":"T8122"},{"id":"R5770","pred":"advmod","subj":"T8143","obj":"T8147"},{"id":"R5771","pred":"punct","subj":"T8144","obj":"T8147"},{"id":"R5772","pred":"compound","subj":"T8145","obj":"T8147"},{"id":"R5773","pred":"compound","subj":"T8146","obj":"T8147"},{"id":"R5774","pred":"ROOT","subj":"T8147","obj":"T8147"},{"id":"R5775","pred":"amod","subj":"T8148","obj":"T8149"},{"id":"R5776","pred":"dobj","subj":"T8149","obj":"T8147"},{"id":"R5777","pred":"prep","subj":"T8150","obj":"T8149"},{"id":"R5778","pred":"pobj","subj":"T8151","obj":"T8150"},{"id":"R5779","pred":"cc","subj":"T8152","obj":"T8151"},{"id":"R5780","pred":"compound","subj":"T8153","obj":"T8154"},{"id":"R5781","pred":"appos","subj":"T8154","obj":"T8147"},{"id":"R5782","pred":"mark","subj":"T8155","obj":"T8158"},{"id":"R5783","pred":"compound","subj":"T8156","obj":"T8157"},{"id":"R5784","pred":"nsubj","subj":"T8157","obj":"T8158"},{"id":"R5785","pred":"advcl","subj":"T8158","obj":"T8147"},{"id":"R5786","pred":"aux","subj":"T8159","obj":"T8160"},{"id":"R5787","pred":"xcomp","subj":"T8160","obj":"T8158"},{"id":"R5788","pred":"dobj","subj":"T8161","obj":"T8160"},{"id":"R5789","pred":"punct","subj":"T8162","obj":"T8161"},{"id":"R5790","pred":"compound","subj":"T8163","obj":"T8164"},{"id":"R5791","pred":"appos","subj":"T8164","obj":"T8161"},{"id":"R5792","pred":"punct","subj":"T8165","obj":"T8161"},{"id":"R5793","pred":"punct","subj":"T8166","obj":"T8147"},{"id":"R5794","pred":"prep","subj":"T8167","obj":"T8180"},{"id":"R5795","pred":"pobj","subj":"T8168","obj":"T8167"},{"id":"R5796","pred":"prep","subj":"T8169","obj":"T8168"},{"id":"R5797","pred":"det","subj":"T8170","obj":"T8171"},{"id":"R5798","pred":"pobj","subj":"T8171","obj":"T8169"},{"id":"R5799","pred":"punct","subj":"T8172","obj":"T8180"},{"id":"R5800","pred":"compound","subj":"T8173","obj":"T8174"},{"id":"R5801","pred":"compound","subj":"T8174","obj":"T8175"},{"id":"R5802","pred":"nsubj","subj":"T8175","obj":"T8180"},{"id":"R5803","pred":"acl","subj":"T8176","obj":"T8175"},{"id":"R5804","pred":"prep","subj":"T8177","obj":"T8176"},{"id":"R5805","pred":"det","subj":"T8178","obj":"T8179"},{"id":"R5806","pred":"pobj","subj":"T8179","obj":"T8177"},{"id":"R5807","pred":"ROOT","subj":"T8180","obj":"T8180"},{"id":"R5808","pred":"amod","subj":"T8181","obj":"T8182"},{"id":"R5809","pred":"dobj","subj":"T8182","obj":"T8180"},{"id":"R5810","pred":"prep","subj":"T8183","obj":"T8182"},{"id":"R5811","pred":"pobj","subj":"T8184","obj":"T8183"},{"id":"R5812","pred":"cc","subj":"T8185","obj":"T8184"},{"id":"R5813","pred":"conj","subj":"T8186","obj":"T8184"},{"id":"R5814","pred":"punct","subj":"T8187","obj":"T8189"},{"id":"R5815","pred":"compound","subj":"T8188","obj":"T8189"},{"id":"R5816","pred":"appos","subj":"T8189","obj":"T8186"},{"id":"R5817","pred":"punct","subj":"T8190","obj":"T8186"},{"id":"R5818","pred":"punct","subj":"T8191","obj":"T8180"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
bionlp-st-ge-2016-test-tees
{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T8427","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T8426","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T8425","span":{"begin":325,"end":333},"obj":"Positive_regulation"},{"id":"T8424","span":{"begin":325,"end":333},"obj":"Positive_regulation"},{"id":"T8423","span":{"begin":334,"end":344},"obj":"Gene_expression"},{"id":"T8422","span":{"begin":334,"end":344},"obj":"Gene_expression"},{"id":"T8421","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T8420","span":{"begin":348,"end":352},"obj":"Protein"},{"id":"T8419","span":{"begin":199,"end":206},"obj":"Positive_regulation"},{"id":"T8418","span":{"begin":170,"end":178},"obj":"Protein"},{"id":"T8417","span":{"begin":27,"end":30},"obj":"Protein"}],"relations":[{"id":"R6015","pred":"themeOf","subj":"T8418","obj":"T8419"},{"id":"R6016","pred":"themeOf","subj":"T8420","obj":"T8422"},{"id":"R6017","pred":"themeOf","subj":"T8421","obj":"T8423"},{"id":"R6018","pred":"themeOf","subj":"T8422","obj":"T8424"},{"id":"R6019","pred":"themeOf","subj":"T8423","obj":"T8425"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}
testone
{"project":"testone","denotations":[{"id":"T7656","span":{"begin":334,"end":344},"obj":"Gene_expression"},{"id":"T7655","span":{"begin":325,"end":333},"obj":"Positive_regulation"},{"id":"T7654","span":{"begin":241,"end":250},"obj":"Negative_regulation"},{"id":"T7653","span":{"begin":199,"end":206},"obj":"Positive_regulation"},{"id":"T7652","span":{"begin":121,"end":130},"obj":"Negative_regulation"},{"id":"T7641","span":{"begin":544,"end":548},"obj":"Protein"},{"id":"T7640","span":{"begin":536,"end":539},"obj":"Protein"},{"id":"T7639","span":{"begin":357,"end":361},"obj":"Protein"},{"id":"T7638","span":{"begin":348,"end":352},"obj":"Protein"}],"relations":[{"id":"R5381","pred":"themeOf","subj":"T7638","obj":"T7656"},{"id":"R5382","pred":"themeOf","subj":"T7639","obj":"T7656"},{"id":"R5393","pred":"themeOf","subj":"T7656","obj":"T7655"}],"text":"To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2). A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A). Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A). In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B)."}