PMC:329117 / 2677-4157 JSONTXT

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Recent computational investigations have provided the almost complete human [5,6] and mouse [1,2] olfactory receptor-gene catalogs. However, the assignment of most of these genes as olfactory receptors is based solely on similarity to one of a relatively small number of experimentally confirmed mouse olfactory receptors or, worse, on similarity to a gene that in turn was defined as an olfactory receptor solely by similarity. While similarity-based genome annotation is a good initial method to identify genes and predict their function, in some cases it can be misleading, as genes of similar sequence can carry out different functions and be expressed in different tissues (for example, the sugar transporter gene family 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