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interaction of olfactory (or odorant) receptors with their odorant ligands is the first step in a signal transduction pathway that results in the perception of smell. The olfactory receptor gene family is one of the largest in the mammalian genome, comprising about 1,500 members in the mouse genome [1,2]. Olfactory receptors were originally identified in an elegant experiment based on the hypothesis that they would be seven-transmembrane-domain proteins encoded by a large, diverse gene family whose expression is restricted to the olfactory epithelium [3]. Subsequent studies have shown that some of these receptors do indeed respond to odorants and can confer that responsivity when expressed in heterologous cell types (for example [4]). Recent computational investigations have provided the almost complete human [5,6] and mouse [1,2] olfactory receptor-gene catalogs. However, the assignment of most of these genes as olfactory receptors is based solely on similarity to one of a relatively small number of experimentally confirmed mouse olfactory receptors or, worse, on similarity to a gene that in turn was defined as an olfactory receptor solely by similarity. While similarity-based genome annotation is a good initial method to identify genes and predict their function, in some cases it can be misleading, as genes of similar sequence can carry out different functions and be expressed in different tissues (for example, the sugar transporter gene family [7])."}

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The olfactory receptor gene family is one of the largest in the mammalian genome, comprising about 1,500 members in the mouse genome [1,2]. Olfactory receptors were originally identified in an elegant experiment based on the hypothesis that they would be seven-transmembrane-domain proteins encoded by a large, diverse gene family whose expression is restricted to the olfactory epithelium [3]. Subsequent studies have shown that some of these receptors do indeed respond to odorants and can confer that responsivity when expressed in heterologous cell types (for example [4]). Recent computational investigations have provided the almost complete human [5,6] and mouse [1,2] olfactory receptor-gene catalogs. However, the assignment of most of these genes as olfactory receptors is based solely on similarity to one of a relatively small number of experimentally confirmed mouse olfactory receptors or, worse, on similarity to a gene that in turn was defined as an olfactory receptor solely by similarity. While similarity-based genome annotation is a good initial method to identify genes and predict their function, in some cases it can be misleading, as genes of similar sequence can carry out different functions and be expressed in different tissues (for example, the sugar transporter gene family [7])."}

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{"project":"2_test","denotations":[{"id":"14611657-11875048-44684017","span":{"begin":305,"end":306},"obj":"11875048"},{"id":"14611657-11802173-44684018","span":{"begin":307,"end":308},"obj":"11802173"},{"id":"14611657-1840504-44684019","span":{"begin":562,"end":563},"obj":"1840504"},{"id":"14611657-9875846-44684020","span":{"begin":744,"end":745},"obj":"9875846"},{"id":"14611657-11337468-44684021","span":{"begin":826,"end":827},"obj":"11337468"},{"id":"14611657-11423007-44684022","span":{"begin":828,"end":829},"obj":"11423007"},{"id":"14611657-11875048-44684023","span":{"begin":842,"end":843},"obj":"11875048"},{"id":"14611657-11802173-44684024","span":{"begin":844,"end":845},"obj":"11802173"},{"id":"14611657-9868370-44684025","span":{"begin":1476,"end":1477},"obj":"9868370"}],"text":"The interaction of olfactory (or odorant) receptors with their odorant ligands is the first step in a signal transduction pathway that results in the perception of smell. The olfactory receptor gene family is one of the largest in the mammalian genome, comprising about 1,500 members in the mouse genome [1,2]. Olfactory receptors were originally identified in an elegant experiment based on the hypothesis that they would be seven-transmembrane-domain proteins encoded by a large, diverse gene family whose expression is restricted to the olfactory epithelium [3]. Subsequent studies have shown that some of these receptors do indeed respond to odorants and can confer that responsivity when expressed in heterologous cell types (for example [4]). Recent computational investigations have provided the almost complete human [5,6] and mouse [1,2] olfactory receptor-gene catalogs. However, the assignment of most of these genes as olfactory receptors is based solely on similarity to one of a relatively small number of experimentally confirmed mouse olfactory receptors or, worse, on similarity to a gene that in turn was defined as an olfactory receptor solely by similarity. While similarity-based genome annotation is a good initial method to identify genes and predict their function, in some cases it can be misleading, as genes of similar sequence can carry out different functions and be expressed in different tissues (for example, the sugar transporter gene family [7])."}