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PMC:3279418 / 165-1757 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T417 0-11 JJ denotes Spontaneous
T418 12-21 NN denotes mutations
T419 22-24 IN denotes of
T420 25-28 DT denotes the
T421 29-36 NNP denotes Sharpin
T422 37-38 -LRB- denotes (
T423 38-54 JJ denotes SHANK-associated
T424 55-57 NN denotes RH
T425 58-76 JJ denotes domain-interacting
T426 77-84 NN denotes protein
T427 84-85 -COMMA- denotes ,
T428 86-91 JJ denotes other
T429 92-99 NN denotes aliases
T430 99-100 -COLON- denotes :
T431 101-107 NN denotes Rbckl1
T432 107-108 -COMMA- denotes ,
T433 109-114 NN denotes Sipl1
T434 114-115 -RRB- denotes )
T435 116-120 NN denotes gene
T436 121-123 IN denotes in
T437 124-128 NN denotes mice
T438 129-135 VB denotes result
T439 136-138 IN denotes in
T440 139-147 JJ denotes systemic
T441 148-160 NN denotes inflammation
T442 161-165 WDT denotes that
T443 166-168 VB denotes is
T444 169-182 VB denotes characterized
T445 183-185 IN denotes by
T446 186-193 JJ denotes chronic
T447 194-207 JJ denotes proliferative
T448 208-218 NN denotes dermatitis
T449 219-222 CC denotes and
T450 223-235 VB denotes dysregulated
T451 236-245 NN denotes secretion
T452 246-248 IN denotes of
T453 249-250 NN denotes T
T454 251-258 NN denotes helper1
T455 259-260 -LRB- denotes (
T456 260-263 NN denotes Th1
T457 263-264 -RRB- denotes )
T458 265-268 CC denotes and
T459 269-272 NN denotes Th2
T460 273-282 NN denotes cytokines
T461 284-287 DT denotes The
T462 288-296 JJ denotes cellular
T463 297-300 CC denotes and
T464 301-310 JJ denotes molecular
T465 311-321 NN denotes mechanisms
T466 322-332 VB denotes underlying
T467 333-337 DT denotes this
T468 338-350 JJ denotes inflammatory
T469 351-360 NN denotes phenotype
T470 361-367 VB denotes remain
T471 368-375 JJ denotes elusive
T472 377-386 JJ denotes Dendritic
T473 387-392 NN denotes cells
T474 393-396 MD denotes may
T475 397-407 VB denotes contribute
T476 408-410 TO denotes to
T477 411-414 DT denotes the
T478 415-425 NN denotes initiation
T479 426-429 CC denotes and
T480 430-441 NN denotes progression
T481 442-444 IN denotes of
T482 445-448 DT denotes the
T483 449-458 NN denotes phenotype
T484 459-461 IN denotes of
T485 462-479 JJ denotes SHARPIN-deficient
T486 480-484 NN denotes mice
T487 485-492 IN denotes because
T488 493-495 IN denotes of
T489 496-501 PRP-DOLLAR- denotes their
T490 502-509 JJ denotes pivotal
T491 510-514 NN denotes role
T492 515-517 IN denotes in
T493 518-524 JJ denotes innate
T494 525-528 CC denotes and
T495 529-537 JJ denotes adaptive
T496 538-546 NN denotes immunity
T497 548-552 RB denotes Here
T498 553-555 PRP denotes we
T499 556-560 VB denotes show
T500 561-563 IN denotes by
T501 564-568 NN denotes flow
T502 569-578 NN denotes cytometry
T503 579-583 IN denotes that
T504 584-592 NN denotes SHARPIN-
T505 593-603 NN denotes deficiency
T506 604-607 VB denotes did
T507 608-611 RB denotes not
T508 612-617 VB denotes alter
T509 618-621 DT denotes the
T510 622-634 NN denotes distribution
T511 635-637 IN denotes of
T512 638-647 JJ denotes different
T513 648-650 NN denotes DC
T514 651-659 NN denotes subtypes
T515 660-662 IN denotes in
T516 663-666 DT denotes the
T517 667-673 NN denotes spleen
T518 675-677 IN denotes In
T519 678-686 NN denotes response
T520 687-689 TO denotes to
T521 690-699 JJ denotes TOLL-like
T522 700-708 NN denotes receptor
T523 709-710 -LRB- denotes (
T524 710-713 NN denotes TLR
T525 713-714 -RRB- denotes )
T526 715-723 NN denotes agonists
T527 724-727 NN denotes LPS
T528 728-731 CC denotes and
T529 732-736 NN denotes poly
T530 737-738 NN denotes I
T531 738-739 -COLON- denotes :
T532 739-740 NN denotes C
T533 740-741 -COMMA- denotes ,
T534 742-750 VB denotes cultured
T535 751-755 NN denotes bone
T536 756-770 JJ denotes marrow-derived
T537 771-780 JJ denotes dendritic
T538 781-786 NN denotes cells
T539 787-788 -LRB- denotes (
T540 788-792 NN denotes BMDC
T541 792-793 -RRB- denotes )
T542 794-798 IN denotes from
T543 799-801 NN denotes WT
T544 802-805 CC denotes and
T545 806-812 JJ denotes mutant
T546 813-817 NN denotes mice
T547 818-827 VB denotes exhibited
T548 828-835 JJ denotes similar
T549 836-845 NN denotes increases
T550 846-848 IN denotes in
T551 849-859 NN denotes expression
T552 860-862 IN denotes of
T553 863-877 JJ denotes co-stimulatory
T554 878-887 NN denotes molecules
T555 888-892 NN denotes CD40
T556 892-893 -COMMA- denotes ,
T557 894-898 NN denotes CD80
T558 898-899 -COMMA- denotes ,
T559 900-903 CC denotes and
T560 904-908 NN denotes CD86
T561 910-917 RB denotes However
T562 917-918 -COMMA- denotes ,
T563 919-929 VB denotes stimulated
T564 930-947 JJ denotes SHARPIN-deficient
T565 948-952 NN denotes BMDC
T566 953-956 VB denotes had
T567 957-964 VB denotes reduced
T568 965-978 NN denotes transcription
T569 979-982 CC denotes and
T570 983-992 NN denotes secretion
T571 993-995 IN denotes of
T572 996-1012 JJ denotes pro-inflammatory
T573 1013-1022 NN denotes mediators
T574 1023-1026 NN denotes IL6
T575 1026-1027 -COMMA- denotes ,
T576 1028-1035 NN denotes IL12P70
T577 1035-1036 -COMMA- denotes ,
T578 1037-1042 NN denotes GMCSF
T579 1042-1043 -COMMA- denotes ,
T580 1044-1047 CC denotes and
T581 1048-1054 JJ denotes nitric
T582 1055-1060 NN denotes oxide
T583 1062-1068 JJ denotes Mutant
T584 1069-1073 NN denotes BMDC
T585 1074-1077 VB denotes had
T586 1078-1087 JJ denotes defective
T587 1088-1098 NN denotes activation
T588 1099-1101 IN denotes of
T589 1102-1107 NN denotes NF-κB
T590 1108-1117 NN denotes signaling
T591 1117-1118 -COMMA- denotes ,
T592 1119-1126 IN denotes whereas
T593 1127-1130 DT denotes the
T594 1131-1138 NN denotes MAPK1/3
T595 1139-1140 -LRB- denotes (
T596 1140-1146 NN denotes ERK1/2
T597 1146-1147 -RRB- denotes )
T598 1148-1151 CC denotes and
T599 1152-1167 NN denotes MAPK11/12/13/14
T600 1168-1169 -LRB- denotes (
T601 1169-1172 NN denotes p38
T602 1173-1176 NN denotes MAP
T603 1177-1183 NN denotes kinase
T604 1184-1192 NN denotes isoforms
T605 1192-1193 -RRB- denotes )
T606 1194-1197 CC denotes and
T607 1198-1202 NN denotes TBK1
T608 1203-1212 NN denotes signaling
T609 1213-1221 NN denotes pathways
T610 1222-1226 VB denotes were
T611 1227-1233 JJ denotes intact
T612 1235-1236 DT denotes A
T613 1237-1242 JJ denotes mixed
T614 1243-1253 NN denotes lymphocyte
T615 1254-1262 NN denotes reaction
T616 1263-1269 VB denotes showed
T617 1270-1274 IN denotes that
T618 1275-1281 JJ denotes mutant
T619 1282-1286 NN denotes BMDC
T620 1287-1291 RB denotes only
T621 1292-1299 VB denotes induced
T622 1300-1301 DT denotes a
T623 1302-1306 JJ denotes weak
T624 1307-1310 NN denotes Th1
T625 1311-1317 JJ denotes immune
T626 1318-1326 NN denotes response
T627 1327-1330 CC denotes but
T628 1331-1341 VB denotes stimulated
T629 1342-1351 VB denotes increased
T630 1352-1355 NN denotes Th2
T631 1356-1364 NN denotes cytokine
T632 1365-1375 NN denotes production
T633 1376-1380 IN denotes from
T634 1381-1391 JJ denotes allogeneic
T635 1392-1397 NN denotes naïve
T636 1398-1402 JJ denotes CD4+
T637 1403-1404 NN denotes T
T638 1405-1410 NN denotes cells
T639 1412-1414 IN denotes In
T640 1415-1425 NN denotes conclusion
T641 1425-1426 -COMMA- denotes ,
T642 1427-1431 NN denotes loss
T643 1432-1434 IN denotes of
T644 1435-1442 NN denotes Sharpin
T645 1443-1445 IN denotes in
T646 1446-1450 NN denotes mice
T647 1451-1464 RB denotes significantly
T648 1465-1472 VB denotes affects
T649 1473-1476 DT denotes the
T650 1477-1483 JJ denotes immune
T651 1484-1492 NN denotes function
T652 1493-1495 IN denotes of
T653 1496-1498 NN denotes DC
T654 1499-1502 CC denotes and
T655 1503-1507 DT denotes this
T656 1508-1511 MD denotes may
T657 1512-1521 RB denotes partially
T658 1522-1529 VB denotes account
T659 1530-1533 IN denotes for
T660 1534-1537 DT denotes the
T661 1538-1546 JJ denotes systemic
T662 1547-1559 NN denotes inflammation
T663 1560-1563 CC denotes and
T664 1564-1574 JJ denotes Th2-biased
T665 1575-1581 JJ denotes immune
T666 1582-1590 NN denotes response
R333 T418 T417 arg1Of mutations,Spontaneous
R334 T418 T419 arg1Of mutations,of
R335 T426 T419 arg2Of protein,of
R336 T426 T420 arg1Of protein,the
R337 T426 T421 arg1Of protein,Sharpin
R338 T426 T422 arg1Of protein,(
R339 T426 T423 arg1Of protein,SHANK-associated
R340 T426 T424 arg1Of protein,RH
R341 T426 T425 arg1Of protein,domain-interacting
R342 T426 T427 arg1Of protein,","
R343 T429 T427 arg2Of aliases,","
R344 T429 T428 arg1Of aliases,other
R345 T429 T430 arg1Of aliases,:
R346 T431 T432 arg1Of Rbckl1,","
R347 T431 T438 arg1Of Rbckl1,result
R348 T433 T432 arg2Of Sipl1,","
R349 T433 T434 arg1Of Sipl1,)
R350 T433 T435 arg1Of Sipl1,gene
R351 T433 T436 arg1Of Sipl1,in
R352 T437 T436 arg2Of mice,in
R353 T438 T439 arg1Of result,in
R354 T441 T439 arg2Of inflammation,in
R355 T441 T440 arg1Of inflammation,systemic
R356 T441 T442 arg1Of inflammation,that
R357 T441 T443 arg1Of inflammation,is
R358 T441 T444 arg2Of inflammation,characterized
R359 T444 T443 arg2Of characterized,is
R360 T448 T446 arg1Of dermatitis,chronic
R361 T448 T447 arg1Of dermatitis,proliferative
R362 T448 T449 arg1Of dermatitis,and
R363 T449 T444 arg1Of and,characterized
R364 T449 T445 arg2Of and,by
R365 T451 T449 arg2Of secretion,and
R366 T451 T450 arg2Of secretion,dysregulated
R367 T451 T452 arg1Of secretion,of
R368 T454 T453 arg1Of helper1,T
R369 T454 T455 arg1Of helper1,(
R370 T454 T458 arg1Of helper1,and
R371 T456 T455 arg2Of Th1,(
R372 T457 T455 arg3Of ),(
R373 T459 T458 arg2Of Th2,and
R374 T460 T452 arg2Of cytokines,of
R375 T460 T454 arg1Of cytokines,helper1
R376 T460 T459 arg1Of cytokines,Th2
R377 T462 T463 arg1Of cellular,and
R378 T464 T463 arg2Of molecular,and
R379 T465 T461 arg1Of mechanisms,The
R380 T465 T462 arg1Of mechanisms,cellular
R381 T465 T464 arg1Of mechanisms,molecular
R382 T465 T466 arg1Of mechanisms,underlying
R383 T465 T470 arg1Of mechanisms,remain
R384 T465 T471 arg1Of mechanisms,elusive
R385 T469 T466 arg2Of phenotype,underlying
R386 T469 T467 arg1Of phenotype,this
R387 T469 T468 arg1Of phenotype,inflammatory
R388 T471 T470 arg2Of elusive,remain
R389 T473 T472 arg1Of cells,Dendritic
R390 T473 T474 arg1Of cells,may
R391 T473 T475 arg1Of cells,contribute
R392 T475 T474 arg2Of contribute,may
R393 T475 T476 arg1Of contribute,to
R394 T475 T487 arg1Of contribute,because
R395 T478 T479 arg1Of initiation,and
R396 T479 T476 arg2Of and,to
R397 T479 T477 arg1Of and,the
R398 T479 T481 arg1Of and,of
R399 T480 T479 arg2Of progression,and
R400 T483 T481 arg2Of phenotype,of
R401 T483 T482 arg1Of phenotype,the
R402 T483 T484 arg1Of phenotype,of
R403 T486 T484 arg2Of mice,of
R404 T486 T485 arg1Of mice,SHARPIN-deficient
R405 T487 T488 arg1Of because,of
R406 T491 T487 arg2Of role,because
R407 T491 T489 arg1Of role,their
R408 T491 T490 arg1Of role,pivotal
R409 T491 T492 arg1Of role,in
R410 T493 T494 arg1Of innate,and
R411 T495 T494 arg2Of adaptive,and
R412 T496 T492 arg2Of immunity,in
R413 T496 T493 arg1Of immunity,innate
R414 T496 T495 arg1Of immunity,adaptive
R415 T498 T499 arg1Of we,show
R416 T499 T497 arg1Of show,Here
R417 T499 T500 arg1Of show,by
R418 T502 T500 arg2Of cytometry,by
R419 T502 T501 arg1Of cytometry,flow
R420 T505 T504 arg1Of deficiency,SHARPIN-
R421 T505 T506 arg1Of deficiency,did
R422 T505 T508 arg1Of deficiency,alter
R423 T508 T499 arg2Of alter,show
R424 T508 T503 arg1Of alter,that
R425 T508 T506 arg2Of alter,did
R426 T508 T507 arg1Of alter,not
R427 T510 T508 arg2Of distribution,alter
R428 T510 T509 arg1Of distribution,the
R429 T510 T511 arg1Of distribution,of
R430 T514 T511 arg2Of subtypes,of
R431 T514 T512 arg1Of subtypes,different
R432 T514 T513 arg1Of subtypes,DC
R433 T514 T515 arg1Of subtypes,in
R434 T517 T515 arg2Of spleen,in
R435 T517 T516 arg1Of spleen,the
R436 T519 T518 arg2Of response,In
R437 T519 T520 arg1Of response,to
R438 T524 T523 arg2Of TLR,(
R439 T525 T523 arg3Of ),(
R440 T527 T521 arg1Of LPS,TOLL-like
R441 T527 T522 arg1Of LPS,receptor
R442 T527 T523 arg1Of LPS,(
R443 T527 T526 arg1Of LPS,agonists
R444 T527 T528 arg1Of LPS,and
R445 T528 T520 arg2Of and,to
R446 T530 T531 arg1Of I,:
R447 T531 T528 arg2Of :,and
R448 T531 T529 arg1Of :,poly
R449 T532 T531 arg2Of C,:
R450 T538 T534 arg2Of cells,cultured
R451 T538 T535 arg1Of cells,bone
R452 T538 T536 arg1Of cells,marrow-derived
R453 T538 T537 arg1Of cells,dendritic
R454 T538 T539 arg1Of cells,(
R455 T538 T542 arg1Of cells,from
R456 T538 T547 arg1Of cells,exhibited
R457 T540 T539 arg2Of BMDC,(
R458 T541 T539 arg3Of ),(
R459 T543 T544 arg1Of WT,and
R460 T545 T544 arg2Of mutant,and
R461 T546 T542 arg2Of mice,from
R462 T546 T543 arg1Of mice,WT
R463 T546 T545 arg1Of mice,mutant
R464 T547 T518 arg1Of exhibited,In
R465 T547 T533 arg1Of exhibited,","
R466 T549 T547 arg2Of increases,exhibited
R467 T549 T548 arg1Of increases,similar
R468 T549 T550 arg1Of increases,in
R469 T551 T550 arg2Of expression,in
R470 T551 T552 arg1Of expression,of
R471 T555 T556 arg1Of CD40,","
R472 T556 T559 arg1Of ",",and
R473 T557 T556 arg2Of CD80,","
R474 T559 T552 arg2Of and,of
R475 T559 T553 arg1Of and,co-stimulatory
R476 T559 T554 arg1Of and,molecules
R477 T559 T558 arg1Of and,","
R478 T560 T559 arg2Of CD86,and
R479 T565 T563 arg1Of BMDC,stimulated
R480 T565 T564 arg1Of BMDC,SHARPIN-deficient
R481 T565 T566 arg1Of BMDC,had
R482 T565 T567 arg1Of BMDC,reduced
R483 T567 T561 arg1Of reduced,However
R484 T567 T562 arg1Of reduced,","
R485 T567 T566 arg2Of reduced,had
R486 T568 T569 arg1Of transcription,and
R487 T569 T567 arg2Of and,reduced
R488 T569 T571 arg1Of and,of
R489 T570 T569 arg2Of secretion,and
R490 T573 T572 arg1Of mediators,pro-inflammatory
R491 T574 T575 arg1Of IL6,","
R492 T575 T577 arg1Of ",",","
R493 T576 T575 arg2Of IL12P70,","
R494 T577 T580 arg1Of ",",and
R495 T578 T577 arg2Of GMCSF,","
R496 T580 T571 arg2Of and,of
R497 T580 T573 arg1Of and,mediators
R498 T580 T579 arg1Of and,","
R499 T582 T580 arg2Of oxide,and
R500 T582 T581 arg1Of oxide,nitric
R501 T584 T583 arg1Of BMDC,Mutant
R502 T584 T585 arg1Of BMDC,had
R503 T585 T592 arg1Of had,whereas
R504 T587 T585 arg2Of activation,had
R505 T587 T586 arg1Of activation,defective
R506 T587 T588 arg1Of activation,of
R507 T590 T588 arg2Of signaling,of
R508 T590 T589 arg1Of signaling,NF-κB
R509 T592 T591 arg1Of whereas,","
R510 T594 T593 arg1Of MAPK1/3,the
R511 T594 T595 arg1Of MAPK1/3,(
R512 T594 T598 arg1Of MAPK1/3,and
R513 T596 T595 arg2Of ERK1/2,(
R514 T597 T595 arg3Of ),(
R515 T598 T610 arg1Of and,were
R516 T598 T611 arg1Of and,intact
R517 T599 T600 arg1Of MAPK11/12/13/14,(
R518 T599 T606 arg1Of MAPK11/12/13/14,and
R519 T604 T600 arg2Of isoforms,(
R520 T604 T601 arg1Of isoforms,p38
R521 T604 T602 arg1Of isoforms,MAP
R522 T604 T603 arg1Of isoforms,kinase
R523 T605 T600 arg3Of ),(
R524 T606 T598 arg2Of and,and
R525 T609 T606 arg2Of pathways,and
R526 T609 T607 arg1Of pathways,TBK1
R527 T609 T608 arg1Of pathways,signaling
R528 T610 T592 arg2Of were,whereas
R529 T611 T610 arg2Of intact,were
R530 T615 T612 arg1Of reaction,A
R531 T615 T613 arg1Of reaction,mixed
R532 T615 T614 arg1Of reaction,lymphocyte
R533 T615 T616 arg1Of reaction,showed
R534 T619 T618 arg1Of BMDC,mutant
R535 T619 T621 arg1Of BMDC,induced
R536 T619 T628 arg1Of BMDC,stimulated
R537 T621 T627 arg1Of induced,but
R538 T626 T621 arg2Of response,induced
R539 T626 T622 arg1Of response,a
R540 T626 T623 arg1Of response,weak
R541 T626 T624 arg1Of response,Th1
R542 T626 T625 arg1Of response,immune
R543 T627 T616 arg2Of but,showed
R544 T627 T617 arg1Of but,that
R545 T627 T620 arg1Of but,only
R546 T628 T627 arg2Of stimulated,but
R547 T628 T633 arg1Of stimulated,from
R548 T632 T628 arg2Of production,stimulated
R549 T632 T629 arg2Of production,increased
R550 T632 T630 arg1Of production,Th2
R551 T632 T631 arg1Of production,cytokine
R552 T638 T633 arg2Of cells,from
R553 T638 T634 arg1Of cells,allogeneic
R554 T638 T635 arg1Of cells,naïve
R555 T638 T636 arg1Of cells,CD4+
R556 T638 T637 arg1Of cells,T
R557 T640 T639 arg2Of conclusion,In
R558 T642 T643 arg1Of loss,of
R559 T642 T645 arg1Of loss,in
R560 T642 T648 arg1Of loss,affects
R561 T644 T643 arg2Of Sharpin,of
R562 T646 T645 arg2Of mice,in
R563 T648 T647 arg1Of affects,significantly
R564 T648 T654 arg1Of affects,and
R565 T651 T648 arg2Of function,affects
R566 T651 T649 arg1Of function,the
R567 T651 T650 arg1Of function,immune
R568 T651 T652 arg1Of function,of
R569 T653 T652 arg2Of DC,of
R570 T654 T639 arg1Of and,In
R571 T654 T641 arg1Of and,","
R572 T655 T656 arg1Of this,may
R573 T655 T658 arg1Of this,account
R574 T658 T654 arg2Of account,and
R575 T658 T656 arg2Of account,may
R576 T658 T657 arg1Of account,partially
R577 T658 T659 arg1Of account,for
R578 T662 T661 arg1Of inflammation,systemic
R579 T662 T663 arg1Of inflammation,and
R580 T663 T659 arg2Of and,for
R581 T663 T660 arg1Of and,the
R582 T666 T663 arg2Of response,and
R583 T666 T664 arg1Of response,Th2-biased
R584 T666 T665 arg1Of response,immune

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T136 0-11 NNP denotes Spontaneous
T137 12-21 NNS denotes mutations
T138 22-24 IN denotes of
T139 25-28 DT denotes the
T140 29-36 NNP denotes Sharpin
T141 37-38 -LRB- denotes (
T142 38-54 JJ denotes SHANK-associated
T143 55-57 NNP denotes RH
T144 58-76 NN denotes domain-interacting
T145 77-84 NN denotes protein
T146 84-85 , denotes ,
T147 86-91 JJ denotes other
T148 92-99 NNS denotes aliases
T149 99-100 : denotes :
T150 101-107 NNS denotes Rbckl1
T151 107-108 , denotes ,
T152 109-114 NNP denotes Sipl1
T153 114-115 -RRB- denotes )
T154 116-120 NN denotes gene
T155 121-123 IN denotes in
T156 124-128 NNS denotes mice
T157 129-135 VBP denotes result
T158 136-138 IN denotes in
T159 139-147 JJ denotes systemic
T160 148-160 NN denotes inflammation
T161 161-165 WDT denotes that
T162 166-168 VBZ denotes is
T163 169-182 VBN denotes characterized
T164 183-185 IN denotes by
T165 186-193 JJ denotes chronic
T166 194-207 JJ denotes proliferative
T167 208-218 NN denotes dermatitis
T168 219-222 CC denotes and
T169 223-235 VBD denotes dysregulated
T170 236-245 NN denotes secretion
T171 246-248 IN denotes of
T172 249-250 NNP denotes T
T173 251-258 CD denotes helper1
T174 259-260 -LRB- denotes (
T175 260-263 NN denotes Th1
T176 263-264 -RRB- denotes )
T177 265-268 CC denotes and
T178 269-272 JJ denotes Th2
T179 273-282 NNS denotes cytokines
T180 282-283 . denotes .
T181 284-287 DT denotes The
T182 288-296 JJ denotes cellular
T183 297-300 CC denotes and
T184 301-310 JJ denotes molecular
T185 311-321 NNS denotes mechanisms
T186 322-332 VBG denotes underlying
T187 333-337 DT denotes this
T188 338-350 JJ denotes inflammatory
T189 351-360 NN denotes phenotype
T190 361-367 VBP denotes remain
T191 368-375 JJ denotes elusive
T192 375-376 . denotes .
T193 377-386 JJ denotes Dendritic
T194 387-392 NNS denotes cells
T195 393-396 MD denotes may
T196 397-407 VB denotes contribute
T197 408-410 TO denotes to
T198 411-414 DT denotes the
T199 415-425 NN denotes initiation
T200 426-429 CC denotes and
T201 430-441 NN denotes progression
T202 442-444 IN denotes of
T203 445-448 DT denotes the
T204 449-458 NN denotes phenotype
T205 459-461 IN denotes of
T206 462-479 JJ denotes SHARPIN-deficient
T207 480-484 NNS denotes mice
T225 579-583 WDT denotes that
T208 485-492 IN denotes because
T209 493-495 IN denotes of
T210 496-501 PRP$ denotes their
T211 502-509 JJ denotes pivotal
T212 510-514 NN denotes role
T213 515-517 IN denotes in
T214 518-524 NN denotes innate
T215 525-528 CC denotes and
T216 529-537 JJ denotes adaptive
T217 538-546 NN denotes immunity
T218 546-547 . denotes .
T219 548-552 RB denotes Here
T220 553-555 PRP denotes we
T221 556-560 VBP denotes show
T222 561-563 IN denotes by
T223 564-568 NN denotes flow
T224 569-578 NN denotes cytometry
T226 584-591 NNP denotes SHARPIN
T227 591-592 : denotes -
T228 593-603 NN denotes deficiency
T229 604-607 VBD denotes did
T230 608-611 RB denotes not
T231 612-617 VB denotes alter
T232 618-621 DT denotes the
T233 622-634 NN denotes distribution
T234 635-637 IN denotes of
T235 638-647 JJ denotes different
T236 648-650 NN denotes DC
T237 651-659 NNS denotes subtypes
T238 660-662 IN denotes in
T239 663-666 DT denotes the
T240 667-673 NN denotes spleen
T241 673-674 . denotes .
T242 675-677 IN denotes In
T243 678-686 NN denotes response
T244 687-689 TO denotes to
T245 690-699 JJ denotes TOLL-like
T246 700-708 NN denotes receptor
T247 709-710 -LRB- denotes (
T248 710-713 NNP denotes TLR
T249 713-714 -RRB- denotes )
T250 715-723 VBZ denotes agonists
T251 724-727 NNP denotes LPS
T252 728-731 CC denotes and
T253 732-736 RB denotes poly
T254 737-738 PRP denotes I
T255 738-739 : denotes :
T256 739-740 NNP denotes C
T257 740-741 , denotes ,
T258 742-750 VBD denotes cultured
T259 751-755 NN denotes bone
T260 756-770 JJ denotes marrow-derived
T261 771-780 JJ denotes dendritic
T262 781-786 NNS denotes cells
T263 787-788 -LRB- denotes (
T264 788-792 NNP denotes BMDC
T265 792-793 -RRB- denotes )
T266 794-798 IN denotes from
T267 799-801 NNP denotes WT
T268 802-805 CC denotes and
T269 806-812 JJ denotes mutant
T270 813-817 NNS denotes mice
T271 818-827 VBD denotes exhibited
T272 828-835 JJ denotes similar
T273 836-845 NNS denotes increases
T274 846-848 IN denotes in
T275 849-859 NN denotes expression
T276 860-862 IN denotes of
T277 863-877 JJ denotes co-stimulatory
T278 878-887 NNS denotes molecules
T279 888-892 NNP denotes CD40
T280 892-893 , denotes ,
T281 894-898 NNP denotes CD80
T282 898-899 , denotes ,
T283 900-903 CC denotes and
T284 904-908 NNP denotes CD86
T285 908-909 . denotes .
T286 910-917 RB denotes However
T287 917-918 , denotes ,
T288 919-929 VBD denotes stimulated
T289 930-947 JJ denotes SHARPIN-deficient
T290 948-952 NNP denotes BMDC
T291 953-956 VBD denotes had
T292 957-964 VBN denotes reduced
T293 965-978 NN denotes transcription
T294 979-982 CC denotes and
T295 983-992 NN denotes secretion
T296 993-995 IN denotes of
T297 996-1012 JJ denotes pro-inflammatory
T298 1013-1022 NNS denotes mediators
T299 1023-1026 NNP denotes IL6
T300 1026-1027 , denotes ,
T301 1028-1035 NNP denotes IL12P70
T302 1035-1036 , denotes ,
T303 1037-1042 NNP denotes GMCSF
T304 1042-1043 , denotes ,
T305 1044-1047 CC denotes and
T306 1048-1054 JJ denotes nitric
T307 1055-1060 NN denotes oxide
T308 1060-1061 . denotes .
T309 1062-1068 JJ denotes Mutant
T310 1069-1073 NNP denotes BMDC
T311 1074-1077 VBD denotes had
T312 1078-1087 JJ denotes defective
T313 1088-1098 NN denotes activation
T314 1099-1101 IN denotes of
T315 1102-1107 JJ denotes NF-κB
T316 1108-1117 VBG denotes signaling
T317 1117-1118 , denotes ,
T318 1119-1126 IN denotes whereas
T319 1127-1130 DT denotes the
T320 1131-1138 NNP denotes MAPK1/3
T321 1139-1140 -LRB- denotes (
T322 1140-1146 NNP denotes ERK1/2
T323 1146-1147 -RRB- denotes )
T324 1148-1151 CC denotes and
T325 1152-1164 NNP denotes MAPK11/12/13
T326 1164-1165 NNP denotes /
T327 1165-1167 CD denotes 14
T328 1168-1169 -LRB- denotes (
T329 1169-1172 CD denotes p38
T330 1173-1176 NNP denotes MAP
T331 1177-1183 NN denotes kinase
T332 1184-1192 VBZ denotes isoforms
T333 1192-1193 -RRB- denotes )
T334 1194-1197 CC denotes and
T335 1198-1202 CD denotes TBK1
T336 1203-1212 VBG denotes signaling
T337 1213-1221 NNS denotes pathways
T338 1222-1226 VBD denotes were
T339 1227-1233 JJ denotes intact
T340 1233-1234 . denotes .
T341 1235-1236 DT denotes A
T342 1237-1242 JJ denotes mixed
T343 1243-1253 NN denotes lymphocyte
T344 1254-1262 NN denotes reaction
T345 1263-1269 VBD denotes showed
T346 1270-1274 IN denotes that
T347 1275-1281 JJ denotes mutant
T348 1282-1286 NNP denotes BMDC
T349 1287-1291 RB denotes only
T350 1292-1299 VBD denotes induced
T351 1300-1301 DT denotes a
T352 1302-1306 JJ denotes weak
T353 1307-1310 CD denotes Th1
T354 1311-1317 JJ denotes immune
T355 1318-1326 NN denotes response
T356 1327-1330 CC denotes but
T357 1331-1341 VBD denotes stimulated
T358 1342-1351 VBN denotes increased
T359 1352-1355 JJ denotes Th2
T360 1356-1364 NN denotes cytokine
T361 1365-1375 NN denotes production
T362 1376-1380 IN denotes from
T363 1381-1391 JJ denotes allogeneic
T364 1392-1397 NN denotes naïve
T365 1398-1401 NNP denotes CD4
T366 1401-1402 NNP denotes +
T367 1403-1404 NNP denotes T
T368 1405-1410 NNS denotes cells
T369 1410-1411 . denotes .
T370 1412-1414 IN denotes In
T371 1415-1425 NN denotes conclusion
T372 1425-1426 , denotes ,
T373 1427-1431 NN denotes loss
T374 1432-1434 IN denotes of
T375 1435-1442 NNP denotes Sharpin
T376 1443-1445 IN denotes in
T377 1446-1450 NNS denotes mice
T378 1451-1464 RB denotes significantly
T379 1465-1472 VBZ denotes affects
T380 1473-1476 DT denotes the
T381 1477-1483 JJ denotes immune
T382 1484-1492 NN denotes function
T383 1493-1495 IN denotes of
T384 1496-1498 NNP denotes DC
T385 1499-1502 CC denotes and
T386 1503-1507 DT denotes this
T387 1508-1511 MD denotes may
T388 1512-1521 RB denotes partially
T389 1522-1529 VB denotes account
T390 1530-1533 IN denotes for
T391 1534-1537 DT denotes the
T392 1538-1546 JJ denotes systemic
T393 1547-1559 NN denotes inflammation
T394 1560-1563 CC denotes and
T395 1564-1574 JJ denotes Th2-biased
T396 1575-1581 JJ denotes immune
T397 1582-1590 NN denotes response
T398 1590-1591 . denotes .
R71 T155 T154 prep in,gene
R72 T156 T155 pobj mice,in
R74 T158 T157 prep in,result
R75 T159 T160 amod systemic,inflammation
R76 T160 T158 pobj inflammation,in
R77 T161 T163 nsubjpass that,characterized
R78 T162 T163 auxpass is,characterized
R79 T163 T160 relcl characterized,inflammation
R80 T164 T163 agent by,characterized
R81 T165 T167 amod chronic,dermatitis
R82 T166 T167 compound proliferative,dermatitis
R83 T167 T164 pobj dermatitis,by
R84 T168 T167 cc and,dermatitis
R85 T169 T170 amod dysregulated,secretion
R86 T170 T167 conj secretion,dermatitis
R87 T171 T170 prep of,secretion
R88 T172 T173 compound T,helper1
R89 T173 T171 pobj helper1,of
R90 T174 T175 punct (,Th1
R91 T175 T170 appos Th1,secretion
R92 T176 T175 punct ),Th1
R93 T177 T170 cc and,secretion
R94 T178 T179 amod Th2,cytokines
R95 T179 T170 conj cytokines,secretion
R96 T180 T157 punct .,result
R97 T181 T185 det The,mechanisms
R98 T182 T185 amod cellular,mechanisms
R99 T183 T182 cc and,cellular
R100 T184 T182 conj molecular,cellular
R101 T185 T190 nsubj mechanisms,remain
R102 T186 T185 acl underlying,mechanisms
R103 T187 T189 det this,phenotype
R104 T188 T189 amod inflammatory,phenotype
R105 T189 T190 nsubj phenotype,remain
R106 T190 T190 ROOT remain,remain
R107 T191 T190 acomp elusive,remain
R108 T192 T190 punct .,remain
R109 T193 T194 amod Dendritic,cells
R110 T194 T196 nsubj cells,contribute
R111 T195 T196 aux may,contribute
R112 T196 T196 ROOT contribute,contribute
R113 T197 T196 prep to,contribute
R114 T198 T199 det the,initiation
R115 T199 T197 pobj initiation,to
R116 T200 T199 cc and,initiation
R117 T201 T199 conj progression,initiation
R118 T202 T199 prep of,initiation
R119 T203 T204 det the,phenotype
R120 T204 T202 pobj phenotype,of
R121 T205 T204 prep of,phenotype
R122 T206 T207 amod SHARPIN-deficient,mice
R123 T207 T205 pobj mice,of
R124 T208 T196 prep because,contribute
R125 T209 T208 pcomp of,because
R126 T210 T212 poss their,role
R127 T211 T212 amod pivotal,role
R128 T212 T208 pobj role,because
R129 T213 T212 prep in,role
R130 T214 T217 amod innate,immunity
R131 T215 T214 cc and,innate
R132 T216 T214 conj adaptive,innate
R133 T217 T213 pobj immunity,in
R134 T218 T196 punct .,contribute
R135 T219 T221 advmod Here,show
R136 T220 T221 nsubj we,show
R137 T221 T221 ROOT show,show
R138 T222 T221 prep by,show
R139 T223 T222 pobj flow,by
R140 T224 T221 dobj cytometry,show
R141 T225 T231 mark that,alter
R142 T226 T228 compound SHARPIN,deficiency
R143 T227 T228 punct -,deficiency
R144 T228 T231 nsubj deficiency,alter
R145 T229 T231 aux did,alter
R146 T230 T231 neg not,alter
R147 T231 T221 ccomp alter,show
R148 T232 T233 det the,distribution
R149 T233 T231 dobj distribution,alter
R150 T234 T233 prep of,distribution
R151 T235 T237 amod different,subtypes
R152 T236 T237 compound DC,subtypes
R153 T237 T234 pobj subtypes,of
R154 T238 T233 prep in,distribution
R155 T239 T240 det the,spleen
R156 T240 T238 pobj spleen,in
R157 T241 T221 punct .,show
R158 T242 T250 nmod In,agonists
R159 T243 T242 pobj response,In
R160 T244 T243 prep to,response
R161 T245 T246 amod TOLL-like,receptor
R162 T246 T244 pobj receptor,to
R163 T247 T248 punct (,TLR
R164 T248 T246 appos TLR,receptor
R165 T249 T242 punct ),In
R166 T250 T250 ROOT agonists,agonists
R167 T251 T250 dobj LPS,agonists
R168 T252 T250 cc and,agonists
R169 T253 T258 advmod poly,cultured
R170 T254 T258 nsubj I,cultured
R171 T255 T256 punct :,C
R172 T256 T258 npadvmod C,cultured
R173 T257 T258 punct ",",cultured
R174 T258 T250 conj cultured,agonists
R175 T259 T262 nmod bone,cells
R176 T260 T262 amod marrow-derived,cells
R177 T261 T262 amod dendritic,cells
R178 T262 T258 dobj cells,cultured
R179 T263 T264 punct (,BMDC
R180 T264 T262 appos BMDC,cells
R181 T265 T264 punct ),BMDC
R182 T266 T264 prep from,BMDC
R183 T267 T266 pobj WT,from
R184 T268 T264 cc and,BMDC
R185 T269 T270 amod mutant,mice
R186 T270 T264 conj mice,BMDC
R187 T271 T258 conj exhibited,cultured
R188 T272 T273 amod similar,increases
R189 T273 T271 dobj increases,exhibited
R190 T274 T273 prep in,increases
R191 T275 T274 pobj expression,in
R192 T276 T275 prep of,expression
R193 T277 T278 amod co-stimulatory,molecules
R194 T278 T276 pobj molecules,of
R195 T279 T273 conj CD40,increases
R196 T280 T279 punct ",",CD40
R197 T281 T279 conj CD80,CD40
R198 T282 T281 punct ",",CD80
R199 T283 T281 cc and,CD80
R200 T284 T281 conj CD86,CD80
R201 T285 T258 punct .,cultured
R202 T286 T288 advmod However,stimulated
R203 T287 T288 punct ",",stimulated
R204 T288 T288 ROOT stimulated,stimulated
R205 T289 T290 compound SHARPIN-deficient,BMDC
R206 T290 T292 nsubj BMDC,reduced
R207 T291 T292 aux had,reduced
R208 T292 T288 ccomp reduced,stimulated
R209 T293 T292 dobj transcription,reduced
R210 T294 T293 cc and,transcription
R211 T295 T293 conj secretion,transcription
R212 T296 T293 prep of,transcription
R213 T297 T298 amod pro-inflammatory,mediators
R214 T298 T296 pobj mediators,of
R215 T299 T292 dobj IL6,reduced
R216 T300 T299 punct ",",IL6
R217 T301 T299 conj IL12P70,IL6
R218 T302 T301 punct ",",IL12P70
R219 T303 T301 conj GMCSF,IL12P70
R220 T304 T303 punct ",",GMCSF
R221 T305 T303 cc and,GMCSF
R222 T306 T307 amod nitric,oxide
R223 T307 T303 conj oxide,GMCSF
R224 T308 T292 punct .,reduced
R225 T309 T310 compound Mutant,BMDC
R226 T310 T311 nsubj BMDC,had
R227 T311 T311 ROOT had,had
R228 T312 T313 amod defective,activation
R229 T313 T311 dobj activation,had
R230 T314 T313 prep of,activation
R231 T315 T316 amod NF-κB,signaling
R232 T316 T314 pobj signaling,of
R233 T317 T311 punct ",",had
R234 T318 T338 mark whereas,were
R235 T319 T320 det the,MAPK1/3
R236 T320 T338 nsubj MAPK1/3,were
R237 T321 T322 punct (,ERK1/2
R238 T322 T320 appos ERK1/2,MAPK1/3
R239 T323 T322 punct ),ERK1/2
R240 T324 T320 cc and,MAPK1/3
R241 T325 T326 compound MAPK11/12/13,/
R242 T326 T338 nsubj /,were
R243 T327 T326 nummod 14,/
R244 T328 T332 punct (,isoforms
R245 T329 T331 nummod p38,kinase
R246 T330 T331 compound MAP,kinase
R247 T331 T332 nsubj kinase,isoforms
R248 T332 T326 parataxis isoforms,/
R249 T333 T332 punct ),isoforms
R250 T334 T326 cc and,/
R251 T335 T337 nummod TBK1,pathways
R252 T336 T337 compound signaling,pathways
R253 T337 T326 conj pathways,/
R254 T338 T311 advcl were,had
R255 T339 T338 acomp intact,were
R256 T340 T311 punct .,had
R257 T341 T344 det A,reaction
R258 T342 T344 amod mixed,reaction
R259 T343 T344 compound lymphocyte,reaction
R260 T344 T345 nsubj reaction,showed
R261 T345 T345 ROOT showed,showed
R262 T346 T350 mark that,induced
R263 T347 T348 compound mutant,BMDC
R264 T348 T350 nsubj BMDC,induced
R265 T349 T350 advmod only,induced
R266 T350 T345 ccomp induced,showed
R267 T351 T355 det a,response
R268 T352 T355 amod weak,response
R269 T353 T355 nummod Th1,response
R270 T354 T355 amod immune,response
R271 T355 T350 dobj response,induced
R272 T356 T350 cc but,induced
R273 T357 T350 conj stimulated,induced
R274 T358 T361 amod increased,production
R275 T359 T361 amod Th2,production
R276 T360 T361 compound cytokine,production
R277 T361 T357 dobj production,stimulated
R278 T362 T361 prep from,production
R279 T363 T364 amod allogeneic,naïve
R280 T364 T368 amod naïve,cells
R281 T365 T368 compound CD4,cells
R282 T366 T368 compound +,cells
R283 T367 T368 compound T,cells
R284 T368 T362 pobj cells,from
R285 T369 T345 punct .,showed
R286 T370 T379 prep In,affects
R287 T371 T370 pobj conclusion,In
R288 T372 T379 punct ",",affects
R289 T373 T379 nsubj loss,affects
R290 T374 T373 prep of,loss
R291 T375 T374 pobj Sharpin,of
R292 T376 T373 prep in,loss
R293 T377 T376 pobj mice,in
R294 T378 T379 advmod significantly,affects
R295 T379 T379 ROOT affects,affects
R296 T380 T382 det the,function
R297 T381 T382 amod immune,function
R298 T382 T379 dobj function,affects
R299 T383 T382 prep of,function
R300 T384 T383 pobj DC,of
R301 T385 T379 cc and,affects
R302 T386 T389 nsubj this,account
R303 T387 T389 aux may,account
R304 T388 T389 advmod partially,account
R305 T389 T379 conj account,affects
R306 T390 T389 prep for,account
R307 T391 T393 det the,inflammation
R308 T392 T393 amod systemic,inflammation
R309 T393 T390 pobj inflammation,for
R310 T394 T393 cc and,inflammation
R311 T395 T397 amod Th2-biased,response
R312 T396 T397 amod immune,response
R313 T397 T393 conj response,inflammation
R314 T398 T389 punct .,account
R54 T138 T137 prep of,mutations
R55 T139 T140 det the,Sharpin
R56 T140 T138 pobj Sharpin,of
R57 T141 T145 punct (,protein
R58 T142 T145 amod SHANK-associated,protein
R59 T143 T145 compound RH,protein
R60 T144 T145 compound domain-interacting,protein
R61 T145 T140 appos protein,Sharpin
R62 T146 T148 punct ",",aliases
R63 T147 T148 amod other,aliases
R64 T148 T137 conj aliases,mutations
R65 T149 T148 punct :,aliases
R66 T150 T148 conj Rbckl1,aliases
R67 T151 T150 punct ",",Rbckl1
R68 T152 T154 nmod Sipl1,gene
R69 T153 T152 punct ),Sipl1
R70 T154 T157 nsubj gene,result

UBERON-AE

Id Subject Object Predicate Lexical cue
T69 667-673 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T70 751-762 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

GO-BP

Id Subject Object Predicate Lexical cue
T700 1356-1375 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T701 148-160 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T702 1547-1559 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T703 236-245 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T704 983-992 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T705 288-296 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T706 965-978 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T707 1088-1107 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T708 1088-1117 http://purl.obolibrary.org/obo/GO_1901224 denotes activation of NF-κB signaling
T709 1102-1117 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T710 1108-1117 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T711 1203-1212 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T712 1140-1144 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T713 1169-1172 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T714 1198-1202 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T715 1203-1221 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T716 1307-1326 http://purl.obolibrary.org/obo/GO_0042088 denotes Th1 immune response
T717 1311-1326 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T718 1575-1590 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T719 1311-1341 http://purl.obolibrary.org/obo/GO_0002922 denotes immune response but stimulated
T720 1311-1341 http://purl.obolibrary.org/obo/GO_0045089 denotes immune response but stimulated
T721 1311-1341 http://purl.obolibrary.org/obo/GO_0050778 denotes immune response but stimulated
T722 1311-1341 http://purl.obolibrary.org/obo/GO_0002821 denotes immune response but stimulated

GO-MF

Id Subject Object Predicate Lexical cue
T724 1140-1144 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T725 1169-1172 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T726 1198-1202 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1

GO-CC

Id Subject Object Predicate Lexical cue
T727 387-392 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T728 781-786 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T729 1405-1410 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T108 0-100 Sentence denotes Spontaneous mutations of the Sharpin (SHANK-associated RH domain-interacting protein, other aliases:
T109 101-283 Sentence denotes Rbckl1, Sipl1) gene in mice result in systemic inflammation that is characterized by chronic proliferative dermatitis and dysregulated secretion of T helper1 (Th1) and Th2 cytokines.
T110 284-376 Sentence denotes The cellular and molecular mechanisms underlying this inflammatory phenotype remain elusive.
T111 377-547 Sentence denotes Dendritic cells may contribute to the initiation and progression of the phenotype of SHARPIN-deficient mice because of their pivotal role in innate and adaptive immunity.
T112 548-674 Sentence denotes Here we show by flow cytometry that SHARPIN- deficiency did not alter the distribution of different DC subtypes in the spleen.
T113 675-909 Sentence denotes In response to TOLL-like receptor (TLR) agonists LPS and poly I:C, cultured bone marrow-derived dendritic cells (BMDC) from WT and mutant mice exhibited similar increases in expression of co-stimulatory molecules CD40, CD80, and CD86.
T114 910-1061 Sentence denotes However, stimulated SHARPIN-deficient BMDC had reduced transcription and secretion of pro-inflammatory mediators IL6, IL12P70, GMCSF, and nitric oxide.
T115 1062-1234 Sentence denotes Mutant BMDC had defective activation of NF-κB signaling, whereas the MAPK1/3 (ERK1/2) and MAPK11/12/13/14 (p38 MAP kinase isoforms) and TBK1 signaling pathways were intact.
T116 1235-1411 Sentence denotes A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells.
T117 1412-1591 Sentence denotes In conclusion, loss of Sharpin in mice significantly affects the immune function of DC and this may partially account for the systemic inflammation and Th2-biased immune response.
T3 0-100 Sentence denotes Spontaneous mutations of the Sharpin (SHANK-associated RH domain-interacting protein, other aliases:
T4 101-283 Sentence denotes Rbckl1, Sipl1) gene in mice result in systemic inflammation that is characterized by chronic proliferative dermatitis and dysregulated secretion of T helper1 (Th1) and Th2 cytokines.
T5 284-376 Sentence denotes The cellular and molecular mechanisms underlying this inflammatory phenotype remain elusive.
T6 377-547 Sentence denotes Dendritic cells may contribute to the initiation and progression of the phenotype of SHARPIN-deficient mice because of their pivotal role in innate and adaptive immunity.
T7 548-674 Sentence denotes Here we show by flow cytometry that SHARPIN- deficiency did not alter the distribution of different DC subtypes in the spleen.
T8 675-909 Sentence denotes In response to TOLL-like receptor (TLR) agonists LPS and poly I:C, cultured bone marrow-derived dendritic cells (BMDC) from WT and mutant mice exhibited similar increases in expression of co-stimulatory molecules CD40, CD80, and CD86.
T9 910-1061 Sentence denotes However, stimulated SHARPIN-deficient BMDC had reduced transcription and secretion of pro-inflammatory mediators IL6, IL12P70, GMCSF, and nitric oxide.
T10 1062-1234 Sentence denotes Mutant BMDC had defective activation of NF-κB signaling, whereas the MAPK1/3 (ERK1/2) and MAPK11/12/13/14 (p38 MAP kinase isoforms) and TBK1 signaling pathways were intact.
T11 1235-1411 Sentence denotes A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells.
T12 1412-1591 Sentence denotes In conclusion, loss of Sharpin in mice significantly affects the immune function of DC and this may partially account for the systemic inflammation and Th2-biased immune response.

ICD10

Id Subject Object Predicate Lexical cue
T723 208-218 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis

events-check-again

Id Subject Object Predicate Lexical cue
T831 1152-1158 Protein denotes MAPK11
T832 1159-1161 Protein denotes 12
T833 1162-1164 Protein denotes 13
T834 1165-1167 Protein denotes 14
T835 1198-1202 Protein denotes TBK1
T836 1427-1431 Negative_regulation denotes loss
T837 1435-1442 Protein denotes Sharpin
T830 1145-1146 Protein denotes 2
T803 12-21 Negative_regulation denotes mutations
T804 29-36 Protein denotes Sharpin
T805 38-84 Protein denotes SHANK-associated RH domain-interacting protein
T806 101-107 Protein denotes Rbckl1
T807 109-114 Protein denotes Sipl1
T808 462-469 Protein denotes SHARPIN
T809 470-479 Negative_regulation denotes deficient
T810 584-591 Protein denotes SHARPIN
T811 593-603 Negative_regulation denotes deficiency
T812 888-892 Protein denotes CD40
T813 894-898 Protein denotes CD80
T814 904-908 Protein denotes CD86
T815 930-937 Protein denotes SHARPIN
T816 938-947 Negative_regulation denotes deficient
T817 957-964 Negative_regulation denotes reduced
T818 957-964 Negative_regulation denotes reduced
T819 957-964 Negative_regulation denotes reduced
T820 957-964 Negative_regulation denotes reduced
T821 965-978 Transcription denotes transcription
T822 965-978 Transcription denotes transcription
T823 983-992 Gene_expression denotes secretion
T824 983-992 Gene_expression denotes secretion
T825 1023-1026 Protein denotes IL6
T826 1037-1042 Protein denotes GMCSF
T827 1131-1136 Protein denotes MAPK1
T828 1137-1138 Protein denotes 3
T829 1140-1144 Protein denotes ERK1
R711 T826 T822 themeOf GMCSF,transcription
R712 T826 T823 themeOf GMCSF,secretion
R713 T829 T827 equivalentTo ERK1,MAPK1
R714 T830 T828 equivalentTo 2,3
R629 T837 T836 themeOf Sharpin,loss
R694 T804 T803 themeOf Sharpin,mutations
R695 T805 T804 equivalentTo SHANK-associated RH domain-interacting protein,Sharpin
R696 T806 T804 equivalentTo Rbckl1,Sharpin
R697 T807 T804 equivalentTo Sipl1,Sharpin
R698 T808 T809 themeOf SHARPIN,deficient
R699 T810 T811 themeOf SHARPIN,deficiency
R700 T815 T816 themeOf SHARPIN,deficient
R701 T816 T818 causeOf deficient,reduced
R702 T816 T820 causeOf deficient,reduced
R703 T816 T819 causeOf deficient,reduced
R704 T816 T817 causeOf deficient,reduced
R705 T821 T818 themeOf transcription,reduced
R706 T822 T820 themeOf transcription,reduced
R707 T823 T817 themeOf secretion,reduced
R708 T824 T819 themeOf secretion,reduced
R709 T825 T821 themeOf IL6,transcription
R710 T825 T824 themeOf IL6,secretion

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T840 29-36 Protein denotes Sharpin
T841 38-43 Protein denotes SHANK
T842 55-57 Protein denotes RH
T843 101-107 Protein denotes Rbckl1
T844 109-114 Protein denotes Sipl1
T845 249-258 Protein denotes T helper1
T846 260-263 Protein denotes Th1
T847 12-21 Gene_expression denotes mutations
T848 12-21 Gene_expression denotes mutations
T849 12-21 Gene_expression denotes mutations
T850 12-21 Gene_expression denotes mutations
T851 44-54 Gene_expression denotes associated
T852 44-54 Gene_expression denotes associated
T853 44-54 Gene_expression denotes associated
T854 44-54 Gene_expression denotes associated
T855 236-245 Localization denotes secretion
T856 236-245 Localization denotes secretion
T857 223-235 Regulation denotes dysregulated
T858 223-235 Regulation denotes dysregulated
T859 462-469 Protein denotes SHARPIN
T860 470-479 Negative_regulation denotes deficient
T861 584-591 Protein denotes SHARPIN
T862 593-603 Negative_regulation denotes deficiency
T863 690-708 Protein denotes TOLL-like receptor
T864 710-713 Protein denotes TLR
T865 888-892 Protein denotes CD40
T866 894-898 Protein denotes CD80
T867 904-908 Protein denotes CD86
T868 849-859 Gene_expression denotes expression
T869 849-859 Gene_expression denotes expression
T870 849-859 Gene_expression denotes expression
T871 836-845 Positive_regulation denotes increases
T872 836-845 Positive_regulation denotes increases
T873 836-845 Positive_regulation denotes increases
T874 930-937 Protein denotes SHARPIN
T875 1023-1026 Protein denotes IL6
T876 1028-1035 Protein denotes IL12P70
T877 1037-1042 Protein denotes GMCSF
T878 938-947 Negative_regulation denotes deficient
T879 965-978 Transcription denotes transcription
T880 965-978 Transcription denotes transcription
T881 965-978 Transcription denotes transcription
T882 983-992 Localization denotes secretion
T883 983-992 Localization denotes secretion
T884 983-992 Localization denotes secretion
T885 957-964 Negative_regulation denotes reduced
T886 957-964 Negative_regulation denotes reduced
T887 957-964 Negative_regulation denotes reduced
T888 1102-1107 Protein denotes NF-κB
T889 1131-1138 Protein denotes MAPK1/3
T890 1140-1144 Protein denotes ERK1
T891 1169-1192 Protein denotes p38 MAP kinase isoforms
T892 1198-1202 Protein denotes TBK1
T893 1088-1098 Positive_regulation denotes activation
T894 1398-1402 Protein denotes CD4+
T895 1435-1442 Protein denotes Sharpin
T896 1427-1431 Negative_regulation denotes loss
R630 T840 T847 themeOf Sharpin,mutations
R631 T841 T851 themeOf SHANK,associated
R632 T842 T848 themeOf RH,mutations
R634 T843 T849 themeOf Rbckl1,mutations
R636 T844 T850 themeOf Sipl1,mutations
R633 T842 T852 themeOf RH,associated
R635 T843 T853 themeOf Rbckl1,associated
R637 T844 T854 themeOf Sipl1,associated
R638 T845 T855 themeOf T helper1,secretion
R639 T846 T856 themeOf Th1,secretion
R640 T855 T857 themeOf secretion,dysregulated
R641 T856 T858 themeOf secretion,dysregulated
R642 T859 T860 themeOf SHARPIN,deficient
R643 T861 T862 themeOf SHARPIN,deficiency
R644 T865 T868 themeOf CD40,expression
R645 T866 T869 themeOf CD80,expression
R646 T867 T870 themeOf CD86,expression
R647 T868 T871 themeOf expression,increases
R648 T869 T872 themeOf expression,increases
R649 T870 T873 themeOf expression,increases
R650 T874 T878 themeOf SHARPIN,deficient
R651 T875 T879 themeOf IL6,transcription
R652 T875 T882 themeOf IL6,secretion
R653 T876 T880 themeOf IL12P70,transcription
R654 T876 T883 themeOf IL12P70,secretion
R655 T877 T881 themeOf GMCSF,transcription
R656 T877 T884 themeOf GMCSF,secretion
R657 T879 T885 themeOf transcription,reduced
R658 T880 T886 themeOf transcription,reduced
R659 T881 T887 themeOf transcription,reduced
R660 T888 T893 themeOf NF-κB,activation
R661 T895 T896 themeOf Sharpin,loss

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T93 983-992 Gene_expression denotes secretion
T94 1023-1026 Protein denotes IL6
T95 1037-1042 Protein denotes GMCSF
T96 1131-1136 Protein denotes MAPK1
T97 1137-1138 Protein denotes 3
T98 1140-1144 Protein denotes ERK1
T99 1145-1146 Protein denotes 2
T100 1152-1158 Protein denotes MAPK11
T101 1159-1161 Protein denotes 12
T102 1162-1164 Protein denotes 13
T103 1165-1167 Protein denotes 14
T104 1198-1202 Protein denotes TBK1
T105 1427-1431 Negative_regulation denotes loss
T106 1435-1442 Protein denotes Sharpin
T72 12-21 Negative_regulation denotes mutations
T73 29-36 Protein denotes Sharpin
T74 38-84 Protein denotes SHANK-associated RH domain-interacting protein
T75 101-107 Protein denotes Rbckl1
T76 109-114 Protein denotes Sipl1
T77 462-469 Protein denotes SHARPIN
T78 470-479 Negative_regulation denotes deficient
T79 584-591 Protein denotes SHARPIN
T80 593-603 Negative_regulation denotes deficiency
T81 888-892 Protein denotes CD40
T82 894-898 Protein denotes CD80
T83 904-908 Protein denotes CD86
T84 930-937 Protein denotes SHARPIN
T85 938-947 Negative_regulation denotes deficient
T86 957-964 Negative_regulation denotes reduced
T87 957-964 Negative_regulation denotes reduced
T88 957-964 Negative_regulation denotes reduced
T89 957-964 Negative_regulation denotes reduced
T90 965-978 Transcription denotes transcription
T91 965-978 Transcription denotes transcription
T92 983-992 Gene_expression denotes secretion
R36 T94 T90 themeOf IL6,transcription
R37 T94 T93 themeOf IL6,secretion
R38 T95 T91 themeOf GMCSF,transcription
R672 T74 T73 equivalentTo SHANK-associated RH domain-interacting protein,Sharpin
R674 T76 T73 equivalentTo Sipl1,Sharpin
R678 T85 T87 causeOf deficient,reduced
R679 T85 T89 causeOf deficient,reduced
R680 T85 T88 causeOf deficient,reduced
R681 T85 T86 causeOf deficient,reduced
R682 T90 T87 themeOf transcription,reduced
R683 T91 T89 themeOf transcription,reduced
R684 T92 T86 themeOf secretion,reduced
R35 T93 T88 themeOf secretion,reduced
R677 T84 T85 themeOf SHARPIN,deficient
R39 T95 T92 themeOf GMCSF,secretion
R40 T98 T96 equivalentTo ERK1,MAPK1
R41 T99 T97 equivalentTo 2,3
R42 T106 T105 themeOf Sharpin,loss
R671 T73 T72 themeOf Sharpin,mutations
R673 T75 T73 equivalentTo Rbckl1,Sharpin
R675 T77 T78 themeOf SHARPIN,deficient
R676 T79 T80 themeOf SHARPIN,deficiency

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T668 29-36 Q9H0F6 denotes Sharpin
T669 109-114 Q9H0F6 denotes Sipl1
T670 462-469 Q9H0F6 denotes SHARPIN
T671 584-591 Q9H0F6 denotes SHARPIN
T672 888-892 P25942 denotes CD40
T673 894-898 P33681 denotes CD80
T674 904-908 P42081 denotes CD86
T675 930-937 Q9H0F6 denotes SHARPIN
T676 1023-1026 P05231 denotes IL6
T677 1037-1042 P04141 denotes GMCSF
T678 1131-1136 P28482 denotes MAPK1
T679 1140-1144 P27361 denotes ERK1
T680 1152-1158 Q15759 denotes MAPK11
T681 1169-1172 P53778 denotes p38
T682 1169-1172 Q16539 denotes p38
T683 1169-1172 Q15759 denotes p38
T684 1169-1172 O15264 denotes p38
T685 1198-1202 Q9UHD2 denotes TBK1
T686 1398-1401 P01730 denotes CD4
T687 1435-1442 Q9H0F6 denotes Sharpin

test2

Id Subject Object Predicate Lexical cue
T50 894-898 Protein denotes CD80
T51 904-908 Protein denotes CD86
T52 930-937 Protein denotes SHARPIN
T53 938-947 Negative_regulation denotes deficient
T54 957-964 Negative_regulation denotes reduced
T55 965-978 Transcription denotes transcription
T56 1023-1026 Protein denotes IL6
T57 1037-1042 Protein denotes GMCSF
T58 1131-1136 Protein denotes MAPK1
T59 1137-1138 Protein denotes 3
T60 1140-1144 Protein denotes ERK1
T61 1145-1146 Protein denotes 2
T62 1152-1158 Protein denotes MAPK11
T63 1159-1161 Protein denotes 12
T64 1162-1164 Protein denotes 13
T65 1165-1167 Protein denotes 14
T66 1198-1202 Protein denotes TBK1
T67 1427-1431 Negative_regulation denotes loss
T68 1435-1442 Protein denotes Sharpin
T38 12-21 Negative_regulation denotes mutations
T39 29-36 Protein denotes Sharpin
T40 38-84 Protein denotes SHANK-associated RH domain-interacting protein
T41 101-107 Protein denotes Rbckl1
T42 109-114 Protein denotes Sipl1
T43 462-469 Protein denotes SHARPIN
T44 470-479 Negative_regulation denotes deficient
T45 584-591 Protein denotes SHARPIN
T46 593-603 Negative_regulation denotes deficiency
T47 836-845 Positive_regulation denotes increases
T48 849-859 Gene_expression denotes expression
T49 888-892 Protein denotes CD40
R662 T39 T38 themeOf Sharpin,mutations
R663 T40 T39 equivalentTo SHANK-associated RH domain-interacting protein,Sharpin
R664 T41 T39 equivalentTo Rbckl1,Sharpin
R665 T42 T38 themeOf Sipl1,mutations
R666 T42 T39 equivalentTo Sipl1,Sharpin
R667 T43 T44 themeOf SHARPIN,deficient
R668 T45 T46 themeOf SHARPIN,deficiency
R669 T48 T47 themeOf expression,increases
R670 T49 T48 themeOf CD40,expression
R23 T50 T48 themeOf CD80,expression
R24 T51 T48 themeOf CD86,expression
R25 T52 T53 themeOf SHARPIN,deficient
R26 T53 T54 causeOf deficient,reduced
R27 T55 T54 themeOf transcription,reduced
R28 T56 T55 themeOf IL6,transcription
R29 T57 T55 themeOf GMCSF,transcription
R30 T60 T58 equivalentTo ERK1,MAPK1
R31 T60 T59 equivalentTo ERK1,3
R32 T61 T59 equivalentTo 2,3
R33 T61 T58 equivalentTo 2,MAPK1
R34 T68 T67 themeOf Sharpin,loss