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RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability. Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells. Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone."}

{"project":"UBERON-AE","denotations":[{"id":"T322","span":{"begin":656,"end":662},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T321","span":{"begin":367,"end":380},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting up to 1% of the adult population. RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability. Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells. Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone."}

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{"project":"sentences","denotations":[{"id":"T327","span":{"begin":585,"end":732},"obj":"Sentence"},{"id":"T326","span":{"begin":318,"end":584},"obj":"Sentence"},{"id":"T325","span":{"begin":113,"end":317},"obj":"Sentence"},{"id":"T324","span":{"begin":0,"end":112},"obj":"Sentence"},{"id":"T7","span":{"begin":0,"end":112},"obj":"Sentence"},{"id":"T8","span":{"begin":113,"end":317},"obj":"Sentence"},{"id":"T9","span":{"begin":318,"end":584},"obj":"Sentence"},{"id":"T10","span":{"begin":585,"end":732},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting up to 1% of the adult population. RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability. Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells. Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone."}

{"project":"ICD10","denotations":[{"id":"T803","span":{"begin":150,"end":163},"obj":"http://purl.bioontology.org/ontology/ICD10/M13.0"},{"id":"T801","span":{"begin":58,"end":67},"obj":"http://purl.bioontology.org/ontology/ICD10/M13.9"},{"id":"T800","span":{"begin":11,"end":20},"obj":"http://purl.bioontology.org/ontology/ICD10/M13.9"},{"id":"T799","span":{"begin":0,"end":20},"obj":"http://purl.bioontology.org/ontology/ICD10/M06.9"}],"text":"Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting up to 1% of the adult population. RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability. Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells. Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone."}

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