PMC:3218875 / 5880-6985 JSONTXT

{"project":"testone","denotations":[{"id":"T1679","span":{"begin":267,"end":276},"obj":"Positive_regulation"},{"id":"T1678","span":{"begin":152,"end":160},"obj":"Localization"},{"id":"T1677","span":{"begin":115,"end":123},"obj":"Localization"},{"id":"T1669","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T1668","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T1667","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T1666","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T1665","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T1664","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T1663","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T1662","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T1661","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T1660","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T1659","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T1658","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T1657","span":{"begin":0,"end":45},"obj":"Protein"}],"relations":[{"id":"R1275","pred":"themeOf","subj":"T1657","obj":"T1659"},{"id":"R1276","pred":"themeOf","subj":"T1657","obj":"T1678"},{"id":"R1277","pred":"themeOf","subj":"T1657","obj":"T1677"},{"id":"R1278","pred":"equivalentTo","subj":"T1658","obj":"T1657"},{"id":"R1279","pred":"themeOf","subj":"T1659","obj":"T1677"},{"id":"R1280","pred":"themeOf","subj":"T1661","obj":"T1679"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T3270","span":{"begin":1104,"end":1105},"obj":"."},{"id":"T3269","span":{"begin":1102,"end":1104},"obj":"NNP"},{"id":"T3268","span":{"begin":1099,"end":1101},"obj":"IN"},{"id":"T3267","span":{"begin":1088,"end":1098},"obj":"NN"},{"id":"T3266","span":{"begin":1083,"end":1087},"obj":"NN"},{"id":"T3265","span":{"begin":1070,"end":1082},"obj":"JJ"},{"id":"T3264","span":{"begin":1066,"end":1069},"obj":"CC"},{"id":"T3263","span":{"begin":1055,"end":1065},"obj":"NN"},{"id":"T3262","span":{"begin":1049,"end":1054},"obj":"JJ"},{"id":"T3261","span":{"begin":1046,"end":1048},"obj":"TO"},{"id":"T3260","span":{"begin":1035,"end":1045},"obj":"VB"},{"id":"T3259","span":{"begin":1031,"end":1034},"obj":"MD"},{"id":"T3258","span":{"begin":1024,"end":1030},"obj":"NN"},{"id":"T3257","span":{"begin":1018,"end":1023},"obj":"JJ"},{"id":"T3256","span":{"begin":1009,"end":1017},"obj":"JJ"},{"id":"T3255","span":{"begin":1005,"end":1008},"obj":"DT"},{"id":"T3254","span":{"begin":1002,"end":1004},"obj":"IN"},{"id":"T3253","span":{"begin":994,"end":1001},"obj":"NNS"},{"id":"T3252","span":{"begin":990,"end":993},"obj":"NNP"},{"id":"T3251","span":{"begin":982,"end":989},"obj":"JJ"},{"id":"T3250","span":{"begin":977,"end":981},"obj":"IN"},{"id":"T3249","span":{"begin":969,"end":976},"obj":"VBP"},{"id":"T3248","span":{"begin":961,"end":968},"obj":"NNS"},{"id":"T3247","span":{"begin":955,"end":960},"obj":"DT"},{"id":"T3246","span":{"begin":953,"end":954},"obj":","},{"id":"T3245","span":{"begin":945,"end":953},"obj":"RB"},{"id":"T3244","span":{"begin":943,"end":944},"obj":"."},{"id":"T3243","span":{"begin":942,"end":943},"obj":"-RRB-"},{"id":"T3242","span":{"begin":941,"end":942},"obj":"NNP"},{"id":"T3241","span":{"begin":936,"end":941},"obj":"CD"},{"id":"T3240","span":{"begin":935,"end":936},"obj":"NNP"},{"id":"T3239","span":{"begin":932,"end":934},"obj":"IN"},{"id":"T3238","span":{"begin":923,"end":931},"obj":"VBN"},{"id":"T3237","span":{"begin":922,"end":923},"obj":"-LRB-"},{"id":"T3236","span":{"begin":912,"end":921},"obj":"NNS"},{"id":"T3235","span":{"begin":907,"end":911},"obj":"NN"},{"id":"T3234","span":{"begin":895,"end":906},"obj":"JJ"},{"id":"T3233","span":{"begin":891,"end":894},"obj":"CC"},{"id":"T3232","span":{"begin":889,"end":890},"obj":","},{"id":"T3231","span":{"begin":888,"end":889},"obj":"NNP"},{"id":"T3230","span":{"begin":879,"end":887},"obj":"NN"},{"id":"T3229","span":{"begin":877,"end":878},"obj":","},{"id":"T3228","span":{"begin":869,"end":877},"obj":"NN"},{"id":"T3227","span":{"begin":867,"end":868},"obj":","},{"id":"T3226","span":{"begin":856,"end":867},"obj":"NN"},{"id":"T3225","span":{"begin":854,"end":855},"obj":","},{"id":"T3224","span":{"begin":844,"end":854},"obj":"NN"},{"id":"T3223","span":{"begin":841,"end":843},"obj":"IN"},{"id":"T3222","span":{"begin":836,"end":840},"obj":"JJ"},{"id":"T3221","span":{"begin":825,"end":835},"obj":"NNS"},{"id":"T3220","span":{"begin":818,"end":824},"obj":"NN"},{"id":"T3219","span":{"begin":804,"end":817},"obj":"JJ"},{"id":"T3218","span":{"begin":800,"end":803},"obj":"VBP"},{"id":"T3217","span":{"begin":790,"end":799},"obj":"NN"},{"id":"T3216","span":{"begin":787,"end":789},"obj":"NNP"},{"id":"T3215","span":{"begin":784,"end":786},"obj":"IN"},{"id":"T3214","span":{"begin":775,"end":783},"obj":"VBN"},{"id":"T3213","span":{"begin":772,"end":774},"obj":"VB"},{"id":"T3212","span":{"begin":768,"end":771},"obj":"MD"},{"id":"T3211","span":{"begin":763,"end":767},"obj":"WDT"},{"id":"T3210","span":{"begin":755,"end":762},"obj":"NNS"},{"id":"T3209","span":{"begin":751,"end":754},"obj":"NNP"},{"id":"T3208","span":{"begin":740,"end":750},"obj":"JJ"},{"id":"T3207","span":{"begin":734,"end":739},"obj":"JJ"},{"id":"T3206","span":{"begin":732,"end":733},"obj":"."},{"id":"T3205","span":{"begin":731,"end":732},"obj":"NNP"},{"id":"T3204","span":{"begin":726,"end":731},"obj":"CD"},{"id":"T3203","span":{"begin":725,"end":726},"obj":"NNP"},{"id":"T3202","span":{"begin":722,"end":724},"obj":"NNP"},{"id":"T3201","span":{"begin":719,"end":721},"obj":"IN"},{"id":"T3200","span":{"begin":706,"end":718},"obj":"NN"},{"id":"T3199","span":{"begin":698,"end":705},"obj":"NN"},{"id":"T3198","span":{"begin":685,"end":697},"obj":"JJ"},{"id":"T3197","span":{"begin":682,"end":684},"obj":"IN"},{"id":"T3196","span":{"begin":673,"end":681},"obj":"VBN"},{"id":"T3195","span":{"begin":670,"end":672},"obj":"VB"},{"id":"T3194","span":{"begin":667,"end":669},"obj":"TO"},{"id":"T3193","span":{"begin":657,"end":666},"obj":"VBN"},{"id":"T3192","span":{"begin":652,"end":656},"obj":"VBN"},{"id":"T3191","span":{"begin":647,"end":651},"obj":"VBP"},{"id":"T3190","span":{"begin":643,"end":646},"obj":"CC"},{"id":"T3189","span":{"begin":641,"end":642},"obj":","},{"id":"T3188","span":{"begin":636,"end":641},"obj":"NN"},{"id":"T3187","span":{"begin":627,"end":635},"obj":"JJ"},{"id":"T3186","span":{"begin":624,"end":626},"obj":"NNP"},{"id":"T3185","span":{"begin":621,"end":623},"obj":"IN"},{"id":"T3184","span":{"begin":613,"end":620},"obj":"JJ"},{"id":"T3183","span":{"begin":602,"end":612},"obj":"RB"},{"id":"T3182","span":{"begin":597,"end":601},"obj":"RB"},{"id":"T3181","span":{"begin":593,"end":596},"obj":"VBP"},{"id":"T3180","span":{"begin":591,"end":592},"obj":","},{"id":"T3179","span":{"begin":583,"end":591},"obj":"NNS"},{"id":"T3178","span":{"begin":567,"end":582},"obj":"JJ"},{"id":"T3177","span":{"begin":564,"end":566},"obj":"IN"},{"id":"T3176","span":{"begin":557,"end":563},"obj":"NN"},{"id":"T3175","span":{"begin":552,"end":556},"obj":"NNP"},{"id":"T3174","span":{"begin":548,"end":551},"obj":"DT"},{"id":"T3173","span":{"begin":545,"end":547},"obj":"TO"},{"id":"T3172","span":{"begin":535,"end":544},"obj":"VBG"},{"id":"T3171","span":{"begin":525,"end":534},"obj":"NNS"},{"id":"T3170","span":{"begin":517,"end":524},"obj":"NN"},{"id":"T3169","span":{"begin":507,"end":516},"obj":"JJ"},{"id":"T3168","span":{"begin":489,"end":506},"obj":"JJ"},{"id":"T3167","span":{"begin":487,"end":488},"obj":","},{"id":"T3166","span":{"begin":485,"end":487},"obj":"CD"},{"id":"T3165","span":{"begin":477,"end":484},"obj":"NN"},{"id":"T3164","span":{"begin":461,"end":476},"obj":"JJ"},{"id":"T3163","span":{"begin":457,"end":460},"obj":"CC"},{"id":"T3162","span":{"begin":455,"end":456},"obj":"CD"},{"id":"T3161","span":{"begin":447,"end":454},"obj":"NN"},{"id":"T3160","span":{"begin":431,"end":446},"obj":"JJ"},{"id":"T3159","span":{"begin":429,"end":430},"obj":"."},{"id":"T3158","span":{"begin":428,"end":429},"obj":"NNP"},{"id":"T3157","span":{"begin":426,"end":428},"obj":"CD"},{"id":"T3156","span":{"begin":425,"end":426},"obj":"NNP"},{"id":"T3155","span":{"begin":420,"end":424},"obj":"NNS"},{"id":"T3154","span":{"begin":417,"end":419},"obj":"IN"},{"id":"T3153","span":{"begin":407,"end":416},"obj":"NNS"},{"id":"T3152","span":{"begin":390,"end":406},"obj":"JJ"},{"id":"T3151","span":{"begin":382,"end":389},"obj":"IN"},{"id":"T3150","span":{"begin":374,"end":381},"obj":"VBP"},{"id":"T3149","span":{"begin":368,"end":373},"obj":"NNP"},{"id":"T3148","span":{"begin":365,"end":367},"obj":"IN"},{"id":"T3147","span":{"begin":358,"end":364},"obj":"NN"},{"id":"T3146","span":{"begin":353,"end":357},"obj":"NNP"},{"id":"T3145","span":{"begin":340,"end":352},"obj":"JJ"},{"id":"T3144","span":{"begin":336,"end":339},"obj":"DT"},{"id":"T3143","span":{"begin":333,"end":335},"obj":"CC"},{"id":"T3142","span":{"begin":322,"end":332},"obj":"NNS"},{"id":"T3141","span":{"begin":309,"end":321},"obj":"VBG"},{"id":"T3140","span":{"begin":303,"end":308},"obj":"NNP"},{"id":"T3139","span":{"begin":299,"end":302},"obj":"CC"},{"id":"T3138","span":{"begin":292,"end":298},"obj":"NN"},{"id":"T3137","span":{"begin":283,"end":291},"obj":"JJ"},{"id":"T3136","span":{"begin":280,"end":282},"obj":"NNP"},{"id":"T3135","span":{"begin":277,"end":279},"obj":"IN"},{"id":"T3134","span":{"begin":267,"end":276},"obj":"VBN"},{"id":"T3133","span":{"begin":264,"end":266},"obj":"VBZ"},{"id":"T3132","span":{"begin":258,"end":263},"obj":"CD"},{"id":"T3131","span":{"begin":256,"end":257},"obj":"."},{"id":"T3130","span":{"begin":247,"end":256},"obj":"NN"},{"id":"T3129","span":{"begin":244,"end":246},"obj":"NNP"},{"id":"T3128","span":{"begin":241,"end":243},"obj":"IN"},{"id":"T3119","span":{"begin":183,"end":186},"obj":"CD"},{"id":"T3118","span":{"begin":180,"end":182},"obj":"VBZ"},{"id":"T3117","span":{"begin":178,"end":179},"obj":","},{"id":"T3116","span":{"begin":173,"end":178},"obj":"NNS"},{"id":"T3115","span":{"begin":164,"end":172},"obj":"JJ"},{"id":"T3114","span":{"begin":161,"end":163},"obj":"IN"},{"id":"T3113","span":{"begin":152,"end":160},"obj":"VBN"},{"id":"T3112","span":{"begin":142,"end":151},"obj":"RB"},{"id":"T3111","span":{"begin":139,"end":141},"obj":"CC"},{"id":"T3110","span":{"begin":127,"end":138},"obj":"NNS"},{"id":"T3109","span":{"begin":124,"end":126},"obj":"IN"},{"id":"T3108","span":{"begin":115,"end":123},"obj":"VBN"},{"id":"T3107","span":{"begin":106,"end":114},"obj":"RB"},{"id":"T3106","span":{"begin":103,"end":105},"obj":"VB"},{"id":"T3105","span":{"begin":99,"end":102},"obj":"MD"},{"id":"T3104","span":{"begin":94,"end":98},"obj":"WDT"},{"id":"T3103","span":{"begin":84,"end":93},"obj":"NN"},{"id":"T3102","span":{"begin":74,"end":83},"obj":"NN"},{"id":"T3101","span":{"begin":64,"end":73},"obj":"VBN"},{"id":"T3100","span":{"begin":57,"end":63},"obj":"RB"},{"id":"T3099","span":{"begin":55,"end":56},"obj":"DT"},{"id":"T3098","span":{"begin":53,"end":54},"obj":","},{"id":"T3097","span":{"begin":52,"end":53},"obj":"-RRB-"},{"id":"T3096","span":{"begin":47,"end":52},"obj":"CD"},{"id":"T3095","span":{"begin":46,"end":47},"obj":"-LRB-"},{"id":"T3094","span":{"begin":44,"end":45},"obj":"CD"},{"id":"T3093","span":{"begin":36,"end":43},"obj":"NN"},{"id":"T3092","span":{"begin":24,"end":35},"obj":"JJ"},{"id":"T3091","span":{"begin":20,"end":23},"obj":"NN"},{"id":"T3090","span":{"begin":14,"end":19},"obj":"NN"},{"id":"T3089","span":{"begin":5,"end":13},"obj":"NN"},{"id":"T3088","span":{"begin":0,"end":4},"obj":"NNP"},{"id":"T3127","span":{"begin":232,"end":240},"obj":"VBN"},{"id":"T3126","span":{"begin":224,"end":231},"obj":"NNS"},{"id":"T3125","span":{"begin":219,"end":223},"obj":"CD"},{"id":"T3124","span":{"begin":208,"end":218},"obj":"JJ"},{"id":"T3123","span":{"begin":199,"end":207},"obj":"JJ"},{"id":"T3122","span":{"begin":194,"end":198},"obj":"RBS"},{"id":"T3121","span":{"begin":190,"end":193},"obj":"DT"},{"id":"T3120","span":{"begin":187,"end":189},"obj":"IN"}],"relations":[{"id":"R2465","pred":"punct","subj":"T3117","obj":"T3093"},{"id":"R2468","pred":"amod","subj":"T3088","obj":"T3091"},{"id":"R2469","pred":"ROOT","subj":"T3118","obj":"T3118"},{"id":"R2470","pred":"compound","subj":"T3089","obj":"T3091"},{"id":"R2471","pred":"compound","subj":"T3090","obj":"T3091"},{"id":"R2472","pred":"compound","subj":"T3091","obj":"T3093"},{"id":"R2473","pred":"compound","subj":"T3092","obj":"T3093"},{"id":"R2474","pred":"attr","subj":"T3119","obj":"T3118"},{"id":"R2475","pred":"nsubj","subj":"T3093","obj":"T3118"},{"id":"R2476","pred":"nummod","subj":"T3094","obj":"T3093"},{"id":"R2477","pred":"punct","subj":"T3095","obj":"T3093"},{"id":"R2478","pred":"appos","subj":"T3096","obj":"T3093"},{"id":"R2479","pred":"punct","subj":"T3097","obj":"T3093"},{"id":"R2480","pred":"punct","subj":"T3098","obj":"T3093"},{"id":"R2481","pred":"prep","subj":"T3120","obj":"T3119"},{"id":"R2482","pred":"det","subj":"T3099","obj":"T3103"},{"id":"R2483","pred":"advmod","subj":"T3100","obj":"T3101"},{"id":"R2484","pred":"amod","subj":"T3101","obj":"T3103"},{"id":"R2485","pred":"compound","subj":"T3102","obj":"T3103"},{"id":"R2486","pred":"det","subj":"T3121","obj":"T3126"},{"id":"R2487","pred":"appos","subj":"T3103","obj":"T3093"},{"id":"R2488","pred":"nsubjpass","subj":"T3104","obj":"T3108"},{"id":"R2489","pred":"advmod","subj":"T3122","obj":"T3123"},{"id":"R2490","pred":"aux","subj":"T3105","obj":"T3108"},{"id":"R2491","pred":"auxpass","subj":"T3106","obj":"T3108"},{"id":"R2492","pred":"advmod","subj":"T3107","obj":"T3108"},{"id":"R2493","pred":"amod","subj":"T3123","obj":"T3126"},{"id":"R2494","pred":"relcl","subj":"T3108","obj":"T3103"},{"id":"R2495","pred":"agent","subj":"T3109","obj":"T3108"},{"id":"R2496","pred":"pobj","subj":"T3110","obj":"T3109"},{"id":"R2497","pred":"amod","subj":"T3124","obj":"T3126"},{"id":"R2498","pred":"cc","subj":"T3111","obj":"T3110"},{"id":"R2499","pred":"advmod","subj":"T3112","obj":"T3113"},{"id":"R2500","pred":"acl","subj":"T3113","obj":"T3110"},{"id":"R2501","pred":"nummod","subj":"T3125","obj":"T3126"},{"id":"R2502","pred":"agent","subj":"T3114","obj":"T3113"},{"id":"R2503","pred":"pobj","subj":"T3126","obj":"T3120"},{"id":"R2504","pred":"acl","subj":"T3127","obj":"T3126"},{"id":"R2505","pred":"amod","subj":"T3115","obj":"T3116"},{"id":"R2506","pred":"pobj","subj":"T3116","obj":"T3114"},{"id":"R2507","pred":"prep","subj":"T3128","obj":"T3127"},{"id":"R2508","pred":"compound","subj":"T3129","obj":"T3130"},{"id":"R2509","pred":"pobj","subj":"T3130","obj":"T3128"},{"id":"R2510","pred":"punct","subj":"T3131","obj":"T3118"},{"id":"R2511","pred":"nsubjpass","subj":"T3132","obj":"T3134"},{"id":"R2512","pred":"relcl","subj":"T3214","obj":"T3210"},{"id":"R2513","pred":"prep","subj":"T3215","obj":"T3214"},{"id":"R2514","pred":"auxpass","subj":"T3133","obj":"T3134"},{"id":"R2515","pred":"compound","subj":"T3216","obj":"T3217"},{"id":"R2516","pred":"pobj","subj":"T3217","obj":"T3215"},{"id":"R2517","pred":"ROOT","subj":"T3218","obj":"T3218"},{"id":"R2518","pred":"ROOT","subj":"T3134","obj":"T3134"},{"id":"R2519","pred":"amod","subj":"T3219","obj":"T3221"},{"id":"R2520","pred":"compound","subj":"T3220","obj":"T3221"},{"id":"R2521","pred":"prep","subj":"T3135","obj":"T3134"},{"id":"R2522","pred":"attr","subj":"T3221","obj":"T3218"},{"id":"R2523","pred":"amod","subj":"T3222","obj":"T3223"},{"id":"R2524","pred":"prep","subj":"T3223","obj":"T3221"},{"id":"R2525","pred":"nmod","subj":"T3136","obj":"T3138"},{"id":"R2526","pred":"pobj","subj":"T3224","obj":"T3223"},{"id":"R2527","pred":"punct","subj":"T3225","obj":"T3224"},{"id":"R2528","pred":"amod","subj":"T3137","obj":"T3138"},{"id":"R2529","pred":"conj","subj":"T3226","obj":"T3224"},{"id":"R2530","pred":"punct","subj":"T3227","obj":"T3226"},{"id":"R2531","pred":"conj","subj":"T3228","obj":"T3226"},{"id":"R2532","pred":"pobj","subj":"T3138","obj":"T3135"},{"id":"R2533","pred":"punct","subj":"T3229","obj":"T3228"},{"id":"R2534","pred":"compound","subj":"T3230","obj":"T3231"},{"id":"R2535","pred":"conj","subj":"T3231","obj":"T3228"},{"id":"R2536","pred":"cc","subj":"T3139","obj":"T3138"},{"id":"R2537","pred":"punct","subj":"T3232","obj":"T3231"},{"id":"R2538","pred":"cc","subj":"T3233","obj":"T3231"},{"id":"R2539","pred":"amod","subj":"T3234","obj":"T3236"},{"id":"R2540","pred":"nsubj","subj":"T3140","obj":"T3141"},{"id":"R2541","pred":"compound","subj":"T3235","obj":"T3236"},{"id":"R2542","pred":"conj","subj":"T3236","obj":"T3231"},{"id":"R2543","pred":"punct","subj":"T3237","obj":"T3236"},{"id":"R2544","pred":"conj","subj":"T3141","obj":"T3138"},{"id":"R2545","pred":"acl","subj":"T3238","obj":"T3236"},{"id":"R2546","pred":"prep","subj":"T3239","obj":"T3238"},{"id":"R2547","pred":"dobj","subj":"T3142","obj":"T3141"},{"id":"R2548","pred":"pobj","subj":"T3240","obj":"T3239"},{"id":"R2549","pred":"nummod","subj":"T3241","obj":"T3242"},{"id":"R2550","pred":"cc","subj":"T3143","obj":"T3142"},{"id":"R2551","pred":"appos","subj":"T3242","obj":"T3240"},{"id":"R2552","pred":"punct","subj":"T3243","obj":"T3240"},{"id":"R2553","pred":"punct","subj":"T3244","obj":"T3218"},{"id":"R2554","pred":"det","subj":"T3144","obj":"T3147"},{"id":"R2555","pred":"advmod","subj":"T3245","obj":"T3249"},{"id":"R2556","pred":"punct","subj":"T3246","obj":"T3249"},{"id":"R2557","pred":"det","subj":"T3247","obj":"T3248"},{"id":"R2558","pred":"amod","subj":"T3145","obj":"T3147"},{"id":"R2559","pred":"nsubj","subj":"T3248","obj":"T3249"},{"id":"R2560","pred":"ROOT","subj":"T3249","obj":"T3249"},{"id":"R2561","pred":"mark","subj":"T3250","obj":"T3260"},{"id":"R2562","pred":"compound","subj":"T3146","obj":"T3147"},{"id":"R2563","pred":"amod","subj":"T3251","obj":"T3253"},{"id":"R2564","pred":"compound","subj":"T3252","obj":"T3253"},{"id":"R2565","pred":"nsubj","subj":"T3253","obj":"T3260"},{"id":"R2566","pred":"conj","subj":"T3147","obj":"T3142"},{"id":"R2567","pred":"prep","subj":"T3254","obj":"T3253"},{"id":"R2568","pred":"det","subj":"T3255","obj":"T3258"},{"id":"R2569","pred":"amod","subj":"T3256","obj":"T3258"},{"id":"R2570","pred":"prep","subj":"T3148","obj":"T3147"},{"id":"R2571","pred":"amod","subj":"T3257","obj":"T3258"},{"id":"R2572","pred":"pobj","subj":"T3258","obj":"T3254"},{"id":"R2573","pred":"aux","subj":"T3259","obj":"T3260"},{"id":"R2574","pred":"pobj","subj":"T3149","obj":"T3148"},{"id":"R2575","pred":"ccomp","subj":"T3260","obj":"T3249"},{"id":"R2576","pred":"prep","subj":"T3261","obj":"T3260"},{"id":"R2577","pred":"amod","subj":"T3262","obj":"T3263"},{"id":"R2578","pred":"pobj","subj":"T3263","obj":"T3261"},{"id":"R2579","pred":"cc","subj":"T3264","obj":"T3263"},{"id":"R2580","pred":"amod","subj":"T3265","obj":"T3267"},{"id":"R2581","pred":"conj","subj":"T3150","obj":"T3134"},{"id":"R2582","pred":"compound","subj":"T3266","obj":"T3267"},{"id":"R2583","pred":"conj","subj":"T3267","obj":"T3263"},{"id":"R2584","pred":"prep","subj":"T3268","obj":"T3263"},{"id":"R2585","pred":"prep","subj":"T3151","obj":"T3150"},{"id":"R2586","pred":"pobj","subj":"T3269","obj":"T3268"},{"id":"R2587","pred":"punct","subj":"T3270","obj":"T3249"},{"id":"R2588","pred":"amod","subj":"T3152","obj":"T3153"},{"id":"R2589","pred":"pobj","subj":"T3153","obj":"T3151"},{"id":"R2590","pred":"prep","subj":"T3154","obj":"T3153"},{"id":"R2591","pred":"pobj","subj":"T3155","obj":"T3154"},{"id":"R2592","pred":"nmod","subj":"T3156","obj":"T3158"},{"id":"R2593","pred":"nummod","subj":"T3157","obj":"T3158"},{"id":"R2594","pred":"ROOT","subj":"T3158","obj":"T3158"},{"id":"R2595","pred":"punct","subj":"T3159","obj":"T3134"},{"id":"R2596","pred":"amod","subj":"T3160","obj":"T3161"},{"id":"R2597","pred":"nsubj","subj":"T3161","obj":"T3181"},{"id":"R2598","pred":"nummod","subj":"T3162","obj":"T3161"},{"id":"R2599","pred":"cc","subj":"T3163","obj":"T3161"},{"id":"R2600","pred":"amod","subj":"T3164","obj":"T3165"},{"id":"R2601","pred":"conj","subj":"T3165","obj":"T3161"},{"id":"R2602","pred":"nummod","subj":"T3166","obj":"T3165"},{"id":"R2603","pred":"punct","subj":"T3167","obj":"T3165"},{"id":"R2604","pred":"amod","subj":"T3168","obj":"T3171"},{"id":"R2605","pred":"amod","subj":"T3169","obj":"T3170"},{"id":"R2606","pred":"compound","subj":"T3170","obj":"T3171"},{"id":"R2607","pred":"conj","subj":"T3171","obj":"T3165"},{"id":"R2608","pred":"acl","subj":"T3172","obj":"T3171"},{"id":"R2609","pred":"prep","subj":"T3173","obj":"T3172"},{"id":"R2610","pred":"det","subj":"T3174","obj":"T3176"},{"id":"R2611","pred":"compound","subj":"T3175","obj":"T3176"},{"id":"R2615","pred":"pobj","subj":"T3176","obj":"T3173"},{"id":"R2620","pred":"prep","subj":"T3177","obj":"T3176"},{"id":"R2622","pred":"amod","subj":"T3178","obj":"T3179"},{"id":"R2624","pred":"pobj","subj":"T3179","obj":"T3177"},{"id":"R2625","pred":"punct","subj":"T3180","obj":"T3181"},{"id":"R2626","pred":"ROOT","subj":"T3181","obj":"T3181"},{"id":"R2631","pred":"advmod","subj":"T3182","obj":"T3181"},{"id":"R2632","pred":"advmod","subj":"T3183","obj":"T3184"},{"id":"R2634","pred":"acomp","subj":"T3184","obj":"T3181"},{"id":"R2635","pred":"prep","subj":"T3185","obj":"T3184"},{"id":"R2636","pred":"nmod","subj":"T3186","obj":"T3188"},{"id":"R2639","pred":"compound","subj":"T3187","obj":"T3188"},{"id":"R2640","pred":"pobj","subj":"T3188","obj":"T3185"},{"id":"R2641","pred":"punct","subj":"T3189","obj":"T3181"},{"id":"R2642","pred":"cc","subj":"T3190","obj":"T3181"},{"id":"R2643","pred":"aux","subj":"T3191","obj":"T3193"},{"id":"R2644","pred":"auxpass","subj":"T3192","obj":"T3193"},{"id":"R2645","pred":"conj","subj":"T3193","obj":"T3181"},{"id":"R2646","pred":"aux","subj":"T3194","obj":"T3196"},{"id":"R2647","pred":"auxpass","subj":"T3195","obj":"T3196"},{"id":"R2649","pred":"xcomp","subj":"T3196","obj":"T3193"},{"id":"R2650","pred":"prep","subj":"T3197","obj":"T3196"},{"id":"R2651","pred":"amod","subj":"T3198","obj":"T3200"},{"id":"R2653","pred":"amod","subj":"T3199","obj":"T3200"},{"id":"R2655","pred":"pobj","subj":"T3200","obj":"T3197"},{"id":"R2657","pred":"prep","subj":"T3201","obj":"T3200"},{"id":"R2659","pred":"compound","subj":"T3202","obj":"T3203"},{"id":"R2660","pred":"pobj","subj":"T3203","obj":"T3201"},{"id":"R2661","pred":"nummod","subj":"T3204","obj":"T3205"},{"id":"R2665","pred":"conj","subj":"T3205","obj":"T3193"},{"id":"R2668","pred":"punct","subj":"T3206","obj":"T3181"},{"id":"R2669","pred":"amod","subj":"T3207","obj":"T3210"},{"id":"R2674","pred":"amod","subj":"T3208","obj":"T3210"},{"id":"R2677","pred":"compound","subj":"T3209","obj":"T3210"},{"id":"R2678","pred":"nsubj","subj":"T3210","obj":"T3218"},{"id":"R2679","pred":"nsubjpass","subj":"T3211","obj":"T3214"},{"id":"R2680","pred":"aux","subj":"T3212","obj":"T3214"},{"id":"R2681","pred":"auxpass","subj":"T3213","obj":"T3214"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"DLUT931","denotations":[{"id":"T3400","span":{"begin":690,"end":697},"obj":"Positive_regulation"},{"id":"T3399","span":{"begin":267,"end":276},"obj":"Positive_regulation"},{"id":"T3398","span":{"begin":152,"end":160},"obj":"Localization"},{"id":"T3397","span":{"begin":115,"end":123},"obj":"Localization"},{"id":"T3389","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T3388","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T3387","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T3386","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T3385","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T3384","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T3383","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T3382","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T3381","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T3380","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T3379","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T3378","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T3377","span":{"begin":0,"end":45},"obj":"Protein"}],"relations":[{"id":"R2695","pred":"themeOf","subj":"T3379","obj":"T3397"},{"id":"R2696","pred":"themeOf","subj":"T3379","obj":"T3398"},{"id":"R2697","pred":"themeOf","subj":"T3381","obj":"T3399"},{"id":"R2700","pred":"themeOf","subj":"T3386","obj":"T3400"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T3287","span":{"begin":685,"end":689},"obj":"http://www.uniprot.org/uniprot/O00206"},{"id":"T3286","span":{"begin":219,"end":223},"obj":"http://www.uniprot.org/uniprot/O00206"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T1846","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T1845","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T1844","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T1843","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T1842","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T1841","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T1840","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T1839","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T1838","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T1837","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T1836","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T1835","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T1834","span":{"begin":0,"end":45},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T1816","span":{"begin":74,"end":93},"obj":"Antecedent"},{"id":"T1815","span":{"begin":94,"end":98},"obj":"Anaphor"}],"relations":[{"id":"R1313","pred":"boundBy","subj":"T1815","obj":"T1816"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"2_test","denotations":[{"id":"21639951-12847700-4289443","span":{"begin":426,"end":428},"obj":"12847700"},{"id":"21639951-10728757-4289444","span":{"begin":726,"end":728},"obj":"10728757"},{"id":"21639951-17767165-4289445","span":{"begin":729,"end":731},"obj":"17767165"},{"id":"21639951-19772831-4289446","span":{"begin":936,"end":938},"obj":"19772831"},{"id":"21639951-20629986-4289447","span":{"begin":939,"end":941},"obj":"20629986"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"pmc-enju-pas","denotations":[{"id":"T2489","span":{"begin":1102,"end":1104},"obj":"NN"},{"id":"T2488","span":{"begin":1099,"end":1101},"obj":"IN"},{"id":"T2487","span":{"begin":1088,"end":1098},"obj":"NN"},{"id":"T2486","span":{"begin":1083,"end":1087},"obj":"NN"},{"id":"T2485","span":{"begin":1070,"end":1082},"obj":"JJ"},{"id":"T2484","span":{"begin":1066,"end":1069},"obj":"CC"},{"id":"T2483","span":{"begin":1055,"end":1065},"obj":"NN"},{"id":"T2482","span":{"begin":1049,"end":1054},"obj":"NN"},{"id":"T2481","span":{"begin":1046,"end":1048},"obj":"TO"},{"id":"T2480","span":{"begin":1035,"end":1045},"obj":"VB"},{"id":"T2479","span":{"begin":1031,"end":1034},"obj":"MD"},{"id":"T2478","span":{"begin":1024,"end":1030},"obj":"NN"},{"id":"T2477","span":{"begin":1018,"end":1023},"obj":"JJ"},{"id":"T2476","span":{"begin":1009,"end":1017},"obj":"JJ"},{"id":"T2475","span":{"begin":1005,"end":1008},"obj":"DT"},{"id":"T2474","span":{"begin":1002,"end":1004},"obj":"IN"},{"id":"T2473","span":{"begin":994,"end":1001},"obj":"NN"},{"id":"T2472","span":{"begin":990,"end":993},"obj":"NN"},{"id":"T2471","span":{"begin":982,"end":989},"obj":"JJ"},{"id":"T2470","span":{"begin":977,"end":981},"obj":"IN"},{"id":"T2469","span":{"begin":969,"end":976},"obj":"VB"},{"id":"T2468","span":{"begin":961,"end":968},"obj":"NN"},{"id":"T2467","span":{"begin":955,"end":960},"obj":"DT"},{"id":"T2466","span":{"begin":953,"end":954},"obj":"-COMMA-"},{"id":"T2465","span":{"begin":945,"end":953},"obj":"RB"},{"id":"T2464","span":{"begin":942,"end":943},"obj":"-RRB-"},{"id":"T2463","span":{"begin":941,"end":942},"obj":"-RRB-"},{"id":"T2462","span":{"begin":936,"end":941},"obj":"CD"},{"id":"T2461","span":{"begin":935,"end":936},"obj":"-LRB-"},{"id":"T2460","span":{"begin":932,"end":934},"obj":"IN"},{"id":"T2459","span":{"begin":923,"end":931},"obj":"VB"},{"id":"T2458","span":{"begin":922,"end":923},"obj":"-LRB-"},{"id":"T2457","span":{"begin":912,"end":921},"obj":"NN"},{"id":"T2456","span":{"begin":907,"end":911},"obj":"NN"},{"id":"T2455","span":{"begin":895,"end":906},"obj":"JJ"},{"id":"T2454","span":{"begin":891,"end":894},"obj":"CC"},{"id":"T2453","span":{"begin":889,"end":890},"obj":"-COMMA-"},{"id":"T2452","span":{"begin":888,"end":889},"obj":"NN"},{"id":"T2451","span":{"begin":879,"end":887},"obj":"NN"},{"id":"T2450","span":{"begin":877,"end":878},"obj":"-COMMA-"},{"id":"T2449","span":{"begin":869,"end":877},"obj":"NN"},{"id":"T2448","span":{"begin":867,"end":868},"obj":"-COMMA-"},{"id":"T2447","span":{"begin":856,"end":867},"obj":"NN"},{"id":"T2446","span":{"begin":854,"end":855},"obj":"-COMMA-"},{"id":"T2445","span":{"begin":844,"end":854},"obj":"NN"},{"id":"T2444","span":{"begin":841,"end":843},"obj":"IN"},{"id":"T2443","span":{"begin":836,"end":840},"obj":"JJ"},{"id":"T2442","span":{"begin":825,"end":835},"obj":"NN"},{"id":"T2441","span":{"begin":818,"end":824},"obj":"NN"},{"id":"T2440","span":{"begin":804,"end":817},"obj":"JJ"},{"id":"T2439","span":{"begin":800,"end":803},"obj":"VB"},{"id":"T2438","span":{"begin":790,"end":799},"obj":"NN"},{"id":"T2437","span":{"begin":787,"end":789},"obj":"NN"},{"id":"T2436","span":{"begin":784,"end":786},"obj":"IN"},{"id":"T2435","span":{"begin":775,"end":783},"obj":"VB"},{"id":"T2434","span":{"begin":772,"end":774},"obj":"VB"},{"id":"T2433","span":{"begin":768,"end":771},"obj":"MD"},{"id":"T2432","span":{"begin":763,"end":767},"obj":"WDT"},{"id":"T2431","span":{"begin":755,"end":762},"obj":"NN"},{"id":"T2430","span":{"begin":751,"end":754},"obj":"NN"},{"id":"T2429","span":{"begin":740,"end":750},"obj":"JJ"},{"id":"T2428","span":{"begin":734,"end":739},"obj":"JJ"},{"id":"T2427","span":{"begin":731,"end":732},"obj":"-RRB-"},{"id":"T2426","span":{"begin":726,"end":731},"obj":"CD"},{"id":"T2425","span":{"begin":725,"end":726},"obj":"-LRB-"},{"id":"T2424","span":{"begin":722,"end":724},"obj":"NN"},{"id":"T2423","span":{"begin":719,"end":721},"obj":"IN"},{"id":"T2422","span":{"begin":706,"end":718},"obj":"NN"},{"id":"T2421","span":{"begin":698,"end":705},"obj":"JJ"},{"id":"T2420","span":{"begin":685,"end":697},"obj":"JJ"},{"id":"T2419","span":{"begin":682,"end":684},"obj":"IN"},{"id":"T2418","span":{"begin":673,"end":681},"obj":"VB"},{"id":"T2417","span":{"begin":670,"end":672},"obj":"VB"},{"id":"T2416","span":{"begin":667,"end":669},"obj":"TO"},{"id":"T2415","span":{"begin":657,"end":666},"obj":"VB"},{"id":"T2414","span":{"begin":652,"end":656},"obj":"VB"},{"id":"T2413","span":{"begin":647,"end":651},"obj":"VB"},{"id":"T2412","span":{"begin":643,"end":646},"obj":"CC"},{"id":"T2411","span":{"begin":641,"end":642},"obj":"-COMMA-"},{"id":"T2410","span":{"begin":636,"end":641},"obj":"NN"},{"id":"T2409","span":{"begin":627,"end":635},"obj":"JJ"},{"id":"T2408","span":{"begin":624,"end":626},"obj":"NN"},{"id":"T2407","span":{"begin":621,"end":623},"obj":"IN"},{"id":"T2406","span":{"begin":613,"end":620},"obj":"JJ"},{"id":"T2405","span":{"begin":602,"end":612},"obj":"RB"},{"id":"T2404","span":{"begin":597,"end":601},"obj":"RB"},{"id":"T2403","span":{"begin":593,"end":596},"obj":"VB"},{"id":"T2402","span":{"begin":591,"end":592},"obj":"-COMMA-"},{"id":"T2401","span":{"begin":583,"end":591},"obj":"NN"},{"id":"T2400","span":{"begin":567,"end":582},"obj":"JJ"},{"id":"T2399","span":{"begin":564,"end":566},"obj":"IN"},{"id":"T2398","span":{"begin":557,"end":563},"obj":"NN"},{"id":"T2397","span":{"begin":552,"end":556},"obj":"NN"},{"id":"T2396","span":{"begin":548,"end":551},"obj":"DT"},{"id":"T2395","span":{"begin":545,"end":547},"obj":"TO"},{"id":"T2394","span":{"begin":535,"end":544},"obj":"VB"},{"id":"T2393","span":{"begin":525,"end":534},"obj":"NN"},{"id":"T2392","span":{"begin":517,"end":524},"obj":"NN"},{"id":"T2391","span":{"begin":507,"end":516},"obj":"JJ"},{"id":"T2390","span":{"begin":489,"end":506},"obj":"JJ"},{"id":"T2389","span":{"begin":487,"end":488},"obj":"-COMMA-"},{"id":"T2388","span":{"begin":485,"end":487},"obj":"CD"},{"id":"T2387","span":{"begin":477,"end":484},"obj":"NN"},{"id":"T2386","span":{"begin":461,"end":476},"obj":"JJ"},{"id":"T2385","span":{"begin":457,"end":460},"obj":"CC"},{"id":"T2384","span":{"begin":455,"end":456},"obj":"CD"},{"id":"T2383","span":{"begin":447,"end":454},"obj":"NN"},{"id":"T2382","span":{"begin":431,"end":446},"obj":"JJ"},{"id":"T2381","span":{"begin":428,"end":429},"obj":"-RRB-"},{"id":"T2380","span":{"begin":426,"end":428},"obj":"CD"},{"id":"T2379","span":{"begin":425,"end":426},"obj":"-LRB-"},{"id":"T2378","span":{"begin":420,"end":424},"obj":"NN"},{"id":"T2377","span":{"begin":417,"end":419},"obj":"IN"},{"id":"T2376","span":{"begin":407,"end":416},"obj":"NN"},{"id":"T2375","span":{"begin":390,"end":406},"obj":"JJ"},{"id":"T2374","span":{"begin":382,"end":389},"obj":"IN"},{"id":"T2373","span":{"begin":374,"end":381},"obj":"NN"},{"id":"T2372","span":{"begin":368,"end":373},"obj":"NN"},{"id":"T2371","span":{"begin":365,"end":367},"obj":"IN"},{"id":"T2370","span":{"begin":358,"end":364},"obj":"NN"},{"id":"T2369","span":{"begin":353,"end":357},"obj":"NN"},{"id":"T2368","span":{"begin":340,"end":352},"obj":"JJ"},{"id":"T2367","span":{"begin":336,"end":339},"obj":"DT"},{"id":"T2366","span":{"begin":333,"end":335},"obj":"CC"},{"id":"T2365","span":{"begin":322,"end":332},"obj":"NN"},{"id":"T2364","span":{"begin":309,"end":321},"obj":"VB"},{"id":"T2363","span":{"begin":303,"end":308},"obj":"NN"},{"id":"T2362","span":{"begin":299,"end":302},"obj":"CC"},{"id":"T2361","span":{"begin":292,"end":298},"obj":"NN"},{"id":"T2360","span":{"begin":283,"end":291},"obj":"JJ"},{"id":"T2359","span":{"begin":280,"end":282},"obj":"NN"},{"id":"T2358","span":{"begin":277,"end":279},"obj":"IN"},{"id":"T2357","span":{"begin":267,"end":276},"obj":"VB"},{"id":"T2356","span":{"begin":264,"end":266},"obj":"VB"},{"id":"T2355","span":{"begin":258,"end":263},"obj":"NN"},{"id":"T2354","span":{"begin":247,"end":256},"obj":"NN"},{"id":"T2353","span":{"begin":244,"end":246},"obj":"NN"},{"id":"T2352","span":{"begin":241,"end":243},"obj":"IN"},{"id":"T2351","span":{"begin":232,"end":240},"obj":"VB"},{"id":"T2350","span":{"begin":224,"end":231},"obj":"NN"},{"id":"T2349","span":{"begin":219,"end":223},"obj":"NN"},{"id":"T2348","span":{"begin":208,"end":218},"obj":"JJ"},{"id":"T2347","span":{"begin":199,"end":207},"obj":"JJ"},{"id":"T2346","span":{"begin":194,"end":198},"obj":"RB"},{"id":"T2345","span":{"begin":190,"end":193},"obj":"DT"},{"id":"T2344","span":{"begin":187,"end":189},"obj":"IN"},{"id":"T2343","span":{"begin":183,"end":186},"obj":"CD"},{"id":"T2342","span":{"begin":180,"end":182},"obj":"VB"},{"id":"T2341","span":{"begin":178,"end":179},"obj":"-COMMA-"},{"id":"T2340","span":{"begin":173,"end":178},"obj":"NN"},{"id":"T2339","span":{"begin":164,"end":172},"obj":"JJ"},{"id":"T2338","span":{"begin":161,"end":163},"obj":"IN"},{"id":"T2337","span":{"begin":152,"end":160},"obj":"VB"},{"id":"T2336","span":{"begin":142,"end":151},"obj":"RB"},{"id":"T2335","span":{"begin":139,"end":141},"obj":"CC"},{"id":"T2334","span":{"begin":127,"end":138},"obj":"NN"},{"id":"T2333","span":{"begin":124,"end":126},"obj":"IN"},{"id":"T2332","span":{"begin":115,"end":123},"obj":"VB"},{"id":"T2331","span":{"begin":106,"end":114},"obj":"RB"},{"id":"T2330","span":{"begin":103,"end":105},"obj":"VB"},{"id":"T2329","span":{"begin":99,"end":102},"obj":"MD"},{"id":"T2328","span":{"begin":94,"end":98},"obj":"WDT"},{"id":"T2327","span":{"begin":84,"end":93},"obj":"NN"},{"id":"T2326","span":{"begin":74,"end":83},"obj":"NN"},{"id":"T2325","span":{"begin":64,"end":73},"obj":"VB"},{"id":"T2324","span":{"begin":57,"end":63},"obj":"RB"},{"id":"T2323","span":{"begin":55,"end":56},"obj":"DT"},{"id":"T2322","span":{"begin":53,"end":54},"obj":"-COMMA-"},{"id":"T2321","span":{"begin":52,"end":53},"obj":"-RRB-"},{"id":"T2320","span":{"begin":47,"end":52},"obj":"NN"},{"id":"T2319","span":{"begin":46,"end":47},"obj":"-LRB-"},{"id":"T2318","span":{"begin":44,"end":45},"obj":"CD"},{"id":"T2317","span":{"begin":36,"end":43},"obj":"NN"},{"id":"T2316","span":{"begin":24,"end":35},"obj":"JJ"},{"id":"T2315","span":{"begin":20,"end":23},"obj":"NN"},{"id":"T2314","span":{"begin":14,"end":19},"obj":"NN"},{"id":"T2313","span":{"begin":5,"end":13},"obj":"NN"},{"id":"T2312","span":{"begin":0,"end":4},"obj":"JJ"}],"relations":[{"id":"R1933","pred":"arg1Of","subj":"T2438","obj":"T2437"},{"id":"R1934","pred":"arg1Of","subj":"T2442","obj":"T2440"},{"id":"R1935","pred":"arg1Of","subj":"T2442","obj":"T2441"},{"id":"R1798","pred":"arg1Of","subj":"T2317","obj":"T2312"},{"id":"R1799","pred":"arg1Of","subj":"T2317","obj":"T2313"},{"id":"R1800","pred":"arg1Of","subj":"T2317","obj":"T2314"},{"id":"R1801","pred":"arg1Of","subj":"T2317","obj":"T2315"},{"id":"R1802","pred":"arg1Of","subj":"T2317","obj":"T2316"},{"id":"R1803","pred":"arg1Of","subj":"T2317","obj":"T2318"},{"id":"R1804","pred":"arg1Of","subj":"T2317","obj":"T2319"},{"id":"R1805","pred":"arg1Of","subj":"T2317","obj":"T2322"},{"id":"R1806","pred":"arg1Of","subj":"T2317","obj":"T2342"},{"id":"R1807","pred":"arg2Of","subj":"T2320","obj":"T2319"},{"id":"R1808","pred":"arg3Of","subj":"T2321","obj":"T2319"},{"id":"R1809","pred":"arg1Of","subj":"T2325","obj":"T2324"},{"id":"R1810","pred":"arg2Of","subj":"T2327","obj":"T2322"},{"id":"R1811","pred":"arg1Of","subj":"T2327","obj":"T2323"},{"id":"R1812","pred":"arg1Of","subj":"T2327","obj":"T2325"},{"id":"R1813","pred":"arg1Of","subj":"T2327","obj":"T2326"},{"id":"R1814","pred":"arg1Of","subj":"T2327","obj":"T2328"},{"id":"R1815","pred":"arg1Of","subj":"T2327","obj":"T2329"},{"id":"R1816","pred":"arg1Of","subj":"T2327","obj":"T2330"},{"id":"R1817","pred":"arg2Of","subj":"T2327","obj":"T2332"},{"id":"R1818","pred":"arg2Of","subj":"T2327","obj":"T2337"},{"id":"R1819","pred":"arg1Of","subj":"T2332","obj":"T2335"},{"id":"R1820","pred":"arg1Of","subj":"T2334","obj":"T2332"},{"id":"R1821","pred":"arg2Of","subj":"T2334","obj":"T2333"},{"id":"R1822","pred":"arg2Of","subj":"T2335","obj":"T2329"},{"id":"R1823","pred":"arg2Of","subj":"T2335","obj":"T2330"},{"id":"R1824","pred":"arg1Of","subj":"T2335","obj":"T2331"},{"id":"R1825","pred":"arg2Of","subj":"T2337","obj":"T2335"},{"id":"R1826","pred":"arg1Of","subj":"T2337","obj":"T2336"},{"id":"R1827","pred":"arg1Of","subj":"T2340","obj":"T2337"},{"id":"R1828","pred":"arg2Of","subj":"T2340","obj":"T2338"},{"id":"R1829","pred":"arg1Of","subj":"T2340","obj":"T2339"},{"id":"R1830","pred":"arg1Of","subj":"T2342","obj":"T2341"},{"id":"R1831","pred":"arg2Of","subj":"T2343","obj":"T2342"},{"id":"R1832","pred":"arg1Of","subj":"T2343","obj":"T2344"},{"id":"R1833","pred":"arg1Of","subj":"T2348","obj":"T2346"},{"id":"R1834","pred":"arg1Of","subj":"T2348","obj":"T2347"},{"id":"R1835","pred":"arg2Of","subj":"T2350","obj":"T2344"},{"id":"R1836","pred":"arg1Of","subj":"T2350","obj":"T2345"},{"id":"R1837","pred":"arg1Of","subj":"T2350","obj":"T2348"},{"id":"R1838","pred":"arg1Of","subj":"T2350","obj":"T2349"},{"id":"R1839","pred":"arg2Of","subj":"T2350","obj":"T2351"},{"id":"R1840","pred":"arg1Of","subj":"T2351","obj":"T2352"},{"id":"R1841","pred":"arg2Of","subj":"T2354","obj":"T2352"},{"id":"R1842","pred":"arg1Of","subj":"T2354","obj":"T2353"},{"id":"R1843","pred":"arg1Of","subj":"T2355","obj":"T2356"},{"id":"R1844","pred":"arg2Of","subj":"T2355","obj":"T2357"},{"id":"R1845","pred":"arg2Of","subj":"T2357","obj":"T2356"},{"id":"R1846","pred":"arg1Of","subj":"T2357","obj":"T2358"},{"id":"R1847","pred":"arg1Of","subj":"T2357","obj":"T2374"},{"id":"R1848","pred":"arg1Of","subj":"T2361","obj":"T2359"},{"id":"R1849","pred":"arg1Of","subj":"T2361","obj":"T2360"},{"id":"R1850","pred":"arg1Of","subj":"T2361","obj":"T2362"},{"id":"R1851","pred":"arg1Of","subj":"T2362","obj":"T2366"},{"id":"R1852","pred":"arg2Of","subj":"T2365","obj":"T2362"},{"id":"R1853","pred":"arg1Of","subj":"T2365","obj":"T2363"},{"id":"R1854","pred":"arg1Of","subj":"T2365","obj":"T2364"},{"id":"R1855","pred":"arg2Of","subj":"T2366","obj":"T2358"},{"id":"R1856","pred":"arg2Of","subj":"T2370","obj":"T2366"},{"id":"R1857","pred":"arg1Of","subj":"T2370","obj":"T2367"},{"id":"R1858","pred":"arg1Of","subj":"T2370","obj":"T2368"},{"id":"R1859","pred":"arg1Of","subj":"T2370","obj":"T2369"},{"id":"R1860","pred":"arg1Of","subj":"T2370","obj":"T2371"},{"id":"R1861","pred":"arg2Of","subj":"T2373","obj":"T2371"},{"id":"R1862","pred":"arg1Of","subj":"T2373","obj":"T2372"},{"id":"R1863","pred":"arg2Of","subj":"T2376","obj":"T2374"},{"id":"R1864","pred":"arg1Of","subj":"T2376","obj":"T2375"},{"id":"R1865","pred":"arg1Of","subj":"T2376","obj":"T2377"},{"id":"R1866","pred":"arg2Of","subj":"T2378","obj":"T2377"},{"id":"R1867","pred":"arg1Of","subj":"T2378","obj":"T2379"},{"id":"R1868","pred":"arg2Of","subj":"T2380","obj":"T2379"},{"id":"R1869","pred":"arg3Of","subj":"T2381","obj":"T2379"},{"id":"R1870","pred":"arg1Of","subj":"T2383","obj":"T2382"},{"id":"R1871","pred":"arg1Of","subj":"T2383","obj":"T2384"},{"id":"R1872","pred":"arg1Of","subj":"T2383","obj":"T2385"},{"id":"R1873","pred":"arg1Of","subj":"T2385","obj":"T2389"},{"id":"R1874","pred":"arg1Of","subj":"T2385","obj":"T2403"},{"id":"R1875","pred":"arg1Of","subj":"T2385","obj":"T2406"},{"id":"R1876","pred":"arg1Of","subj":"T2385","obj":"T2413"},{"id":"R1877","pred":"arg1Of","subj":"T2385","obj":"T2414"},{"id":"R1878","pred":"arg2Of","subj":"T2385","obj":"T2415"},{"id":"R1879","pred":"arg1Of","subj":"T2385","obj":"T2417"},{"id":"R1880","pred":"arg2Of","subj":"T2385","obj":"T2418"},{"id":"R1881","pred":"arg2Of","subj":"T2387","obj":"T2385"},{"id":"R1882","pred":"arg1Of","subj":"T2387","obj":"T2386"},{"id":"R1883","pred":"arg1Of","subj":"T2387","obj":"T2388"},{"id":"R1884","pred":"arg2Of","subj":"T2393","obj":"T2389"},{"id":"R1885","pred":"arg1Of","subj":"T2393","obj":"T2390"},{"id":"R1886","pred":"arg1Of","subj":"T2393","obj":"T2391"},{"id":"R1887","pred":"arg1Of","subj":"T2393","obj":"T2392"},{"id":"R1888","pred":"arg1Of","subj":"T2393","obj":"T2394"},{"id":"R1889","pred":"arg1Of","subj":"T2394","obj":"T2395"},{"id":"R1890","pred":"arg2Of","subj":"T2398","obj":"T2395"},{"id":"R1891","pred":"arg1Of","subj":"T2398","obj":"T2396"},{"id":"R1892","pred":"arg1Of","subj":"T2398","obj":"T2397"},{"id":"R1893","pred":"arg1Of","subj":"T2398","obj":"T2399"},{"id":"R1894","pred":"arg2Of","subj":"T2401","obj":"T2399"},{"id":"R1895","pred":"arg1Of","subj":"T2401","obj":"T2400"},{"id":"R1896","pred":"arg1Of","subj":"T2403","obj":"T2404"},{"id":"R1897","pred":"arg1Of","subj":"T2403","obj":"T2412"},{"id":"R1898","pred":"arg2Of","subj":"T2406","obj":"T2403"},{"id":"R1899","pred":"arg1Of","subj":"T2406","obj":"T2405"},{"id":"R1900","pred":"arg1Of","subj":"T2406","obj":"T2407"},{"id":"R1901","pred":"arg2Of","subj":"T2410","obj":"T2407"},{"id":"R1902","pred":"arg1Of","subj":"T2410","obj":"T2408"},{"id":"R1903","pred":"arg1Of","subj":"T2410","obj":"T2409"},{"id":"R1904","pred":"arg1Of","subj":"T2412","obj":"T2402"},{"id":"R1905","pred":"arg1Of","subj":"T2412","obj":"T2411"},{"id":"R1906","pred":"arg2Of","subj":"T2415","obj":"T2412"},{"id":"R1907","pred":"arg2Of","subj":"T2415","obj":"T2413"},{"id":"R1908","pred":"arg2Of","subj":"T2415","obj":"T2414"},{"id":"R1909","pred":"arg3Of","subj":"T2418","obj":"T2415"},{"id":"R1910","pred":"arg1Of","subj":"T2418","obj":"T2416"},{"id":"R1911","pred":"arg2Of","subj":"T2418","obj":"T2417"},{"id":"R1912","pred":"arg1Of","subj":"T2418","obj":"T2419"},{"id":"R1913","pred":"arg1Of","subj":"T2418","obj":"T2423"},{"id":"R1914","pred":"arg2Of","subj":"T2422","obj":"T2419"},{"id":"R1915","pred":"arg1Of","subj":"T2422","obj":"T2420"},{"id":"R1916","pred":"arg1Of","subj":"T2422","obj":"T2421"},{"id":"R1917","pred":"arg2Of","subj":"T2424","obj":"T2423"},{"id":"R1918","pred":"arg1Of","subj":"T2424","obj":"T2425"},{"id":"R1919","pred":"arg2Of","subj":"T2426","obj":"T2425"},{"id":"R1920","pred":"arg3Of","subj":"T2427","obj":"T2425"},{"id":"R1921","pred":"arg1Of","subj":"T2431","obj":"T2428"},{"id":"R1922","pred":"arg1Of","subj":"T2431","obj":"T2429"},{"id":"R1923","pred":"arg1Of","subj":"T2431","obj":"T2430"},{"id":"R1924","pred":"arg1Of","subj":"T2431","obj":"T2432"},{"id":"R1925","pred":"arg1Of","subj":"T2431","obj":"T2433"},{"id":"R1926","pred":"arg1Of","subj":"T2431","obj":"T2434"},{"id":"R1927","pred":"arg2Of","subj":"T2431","obj":"T2435"},{"id":"R1928","pred":"arg1Of","subj":"T2431","obj":"T2439"},{"id":"R1929","pred":"arg2Of","subj":"T2435","obj":"T2433"},{"id":"R1930","pred":"arg2Of","subj":"T2435","obj":"T2434"},{"id":"R1931","pred":"arg1Of","subj":"T2435","obj":"T2436"},{"id":"R1932","pred":"arg2Of","subj":"T2438","obj":"T2436"},{"id":"R1936","pred":"arg1Of","subj":"T2442","obj":"T2444"},{"id":"R1937","pred":"arg1Of","subj":"T2442","obj":"T2454"},{"id":"R1938","pred":"arg1Of","subj":"T2444","obj":"T2443"},{"id":"R1939","pred":"arg1Of","subj":"T2445","obj":"T2446"},{"id":"R1940","pred":"arg1Of","subj":"T2446","obj":"T2448"},{"id":"R1941","pred":"arg2Of","subj":"T2447","obj":"T2446"},{"id":"R1942","pred":"arg1Of","subj":"T2448","obj":"T2450"},{"id":"R1943","pred":"arg2Of","subj":"T2449","obj":"T2448"},{"id":"R1944","pred":"arg2Of","subj":"T2450","obj":"T2444"},{"id":"R1945","pred":"arg2Of","subj":"T2452","obj":"T2450"},{"id":"R1946","pred":"arg1Of","subj":"T2452","obj":"T2451"},{"id":"R1947","pred":"arg2Of","subj":"T2454","obj":"T2439"},{"id":"R1948","pred":"arg1Of","subj":"T2454","obj":"T2453"},{"id":"R1949","pred":"arg2Of","subj":"T2457","obj":"T2454"},{"id":"R1950","pred":"arg1Of","subj":"T2457","obj":"T2455"},{"id":"R1951","pred":"arg1Of","subj":"T2457","obj":"T2456"},{"id":"R1952","pred":"arg1Of","subj":"T2457","obj":"T2458"},{"id":"R1953","pred":"arg2Of","subj":"T2459","obj":"T2458"},{"id":"R1954","pred":"arg1Of","subj":"T2459","obj":"T2460"},{"id":"R1955","pred":"arg1Of","subj":"T2459","obj":"T2461"},{"id":"R1956","pred":"arg2Of","subj":"T2462","obj":"T2461"},{"id":"R1957","pred":"arg3Of","subj":"T2463","obj":"T2461"},{"id":"R1958","pred":"arg3Of","subj":"T2464","obj":"T2458"},{"id":"R1959","pred":"arg1Of","subj":"T2468","obj":"T2467"},{"id":"R1960","pred":"arg1Of","subj":"T2468","obj":"T2469"},{"id":"R1961","pred":"arg1Of","subj":"T2469","obj":"T2465"},{"id":"R1962","pred":"arg1Of","subj":"T2469","obj":"T2466"},{"id":"R1963","pred":"arg1Of","subj":"T2473","obj":"T2471"},{"id":"R1964","pred":"arg1Of","subj":"T2473","obj":"T2472"},{"id":"R1965","pred":"arg1Of","subj":"T2473","obj":"T2474"},{"id":"R1966","pred":"arg1Of","subj":"T2473","obj":"T2479"},{"id":"R1967","pred":"arg1Of","subj":"T2473","obj":"T2480"},{"id":"R1968","pred":"arg2Of","subj":"T2478","obj":"T2474"},{"id":"R1969","pred":"arg1Of","subj":"T2478","obj":"T2475"},{"id":"R1970","pred":"arg1Of","subj":"T2478","obj":"T2476"},{"id":"R1971","pred":"arg1Of","subj":"T2478","obj":"T2477"},{"id":"R1972","pred":"arg2Of","subj":"T2480","obj":"T2469"},{"id":"R1973","pred":"arg1Of","subj":"T2480","obj":"T2470"},{"id":"R1974","pred":"arg2Of","subj":"T2480","obj":"T2479"},{"id":"R1975","pred":"arg1Of","subj":"T2480","obj":"T2481"},{"id":"R1976","pred":"arg1Of","subj":"T2483","obj":"T2482"},{"id":"R1977","pred":"arg1Of","subj":"T2483","obj":"T2484"},{"id":"R1978","pred":"arg2Of","subj":"T2484","obj":"T2481"},{"id":"R1979","pred":"arg1Of","subj":"T2484","obj":"T2488"},{"id":"R1980","pred":"arg2Of","subj":"T2487","obj":"T2484"},{"id":"R1981","pred":"arg1Of","subj":"T2487","obj":"T2485"},{"id":"R1982","pred":"arg1Of","subj":"T2487","obj":"T2486"},{"id":"R1983","pred":"arg2Of","subj":"T2489","obj":"T2488"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"UBERON-AE","denotations":[{"id":"T1754","span":{"begin":895,"end":899},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"},{"id":"T1753","span":{"begin":627,"end":641},"obj":"http://purl.obolibrary.org/obo/UBERON_0001090"},{"id":"T1752","span":{"begin":1024,"end":1030},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T1751","span":{"begin":292,"end":298},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"GO-BP","denotations":[{"id":"T2513","span":{"begin":1083,"end":1098},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T2501","span":{"begin":1049,"end":1065},"obj":"http://purl.obolibrary.org/obo/GO_0051092"},{"id":"T2495","span":{"begin":706,"end":718},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"GO-MF","denotations":[{"id":"T2530","span":{"begin":575,"end":591},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T2529","span":{"begin":567,"end":591},"obj":"http://purl.obolibrary.org/obo/GO_0048306"},{"id":"T2528","span":{"begin":322,"end":332},"obj":"http://purl.obolibrary.org/obo/GO_0003823"},{"id":"T2525","span":{"begin":994,"end":1001},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T2524","span":{"begin":755,"end":762},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T2523","span":{"begin":224,"end":231},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"GO-CC","denotations":[{"id":"T2543","span":{"begin":74,"end":83},"obj":"http://purl.obolibrary.org/obo/GO_0000785"},{"id":"T2542","span":{"begin":24,"end":35},"obj":"http://purl.obolibrary.org/obo/GO_0005694"},{"id":"T2540","span":{"begin":322,"end":332},"obj":"http://purl.obolibrary.org/obo/GO_0042571"},{"id":"T2537","span":{"begin":322,"end":332},"obj":"http://purl.obolibrary.org/obo/GO_0019815"},{"id":"T2534","span":{"begin":173,"end":178},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2547","span":{"begin":844,"end":854},"obj":"http://purl.obolibrary.org/obo/GO_0005577"},{"id":"T2546","span":{"begin":804,"end":835},"obj":"http://purl.obolibrary.org/obo/GO_0044420"},{"id":"T2545","span":{"begin":804,"end":824},"obj":"http://purl.obolibrary.org/obo/GO_0031012"},{"id":"T2544","span":{"begin":804,"end":817},"obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"sentences","denotations":[{"id":"T1772","span":{"begin":945,"end":1105},"obj":"Sentence"},{"id":"T1771","span":{"begin":734,"end":944},"obj":"Sentence"},{"id":"T1770","span":{"begin":431,"end":733},"obj":"Sentence"},{"id":"T1769","span":{"begin":258,"end":430},"obj":"Sentence"},{"id":"T1768","span":{"begin":0,"end":257},"obj":"Sentence"},{"id":"T33","span":{"begin":0,"end":257},"obj":"Sentence"},{"id":"T34","span":{"begin":258,"end":430},"obj":"Sentence"},{"id":"T35","span":{"begin":431,"end":733},"obj":"Sentence"},{"id":"T36","span":{"begin":734,"end":944},"obj":"Sentence"},{"id":"T37","span":{"begin":945,"end":1105},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"ICD10","denotations":[{"id":"T2515","span":{"begin":407,"end":416},"obj":"http://purl.bioontology.org/ontology/ICD10/M13.9"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"simple1","denotations":[{"id":"T2603","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T2602","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T2601","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T2600","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T2599","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T2598","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T2597","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T2596","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T2595","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T2594","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T2593","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T2592","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T2591","span":{"begin":0,"end":45},"obj":"Protein"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T3583","span":{"begin":690,"end":697},"obj":"Positive_regulation"},{"id":"T3582","span":{"begin":267,"end":276},"obj":"Positive_regulation"},{"id":"T3581","span":{"begin":152,"end":160},"obj":"Localization"},{"id":"T3580","span":{"begin":115,"end":123},"obj":"Localization"},{"id":"T3573","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T3572","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T3571","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T3570","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T3569","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T3568","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T3567","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T3566","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T3565","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T3564","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T3563","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T3562","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T3561","span":{"begin":0,"end":45},"obj":"Protein"}],"relations":[{"id":"R2761","pred":"themeOf","subj":"T3561","obj":"T3580"},{"id":"R2762","pred":"themeOf","subj":"T3561","obj":"T3581"},{"id":"R2763","pred":"themeOf","subj":"T3562","obj":"T3581"},{"id":"R2764","pred":"themeOf","subj":"T3563","obj":"T3580"},{"id":"R2765","pred":"themeOf","subj":"T3563","obj":"T3581"},{"id":"R2766","pred":"themeOf","subj":"T3564","obj":"T3581"},{"id":"R2767","pred":"themeOf","subj":"T3565","obj":"T3582"},{"id":"R2769","pred":"themeOf","subj":"T3570","obj":"T3583"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T3327","span":{"begin":690,"end":697},"obj":"Positive_regulation"},{"id":"T3326","span":{"begin":267,"end":276},"obj":"Positive_regulation"},{"id":"T3325","span":{"begin":152,"end":160},"obj":"Localization"},{"id":"T3324","span":{"begin":115,"end":123},"obj":"Localization"},{"id":"T3317","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T3316","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T3315","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T3314","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T3313","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T3312","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T3311","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T3310","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T3309","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T3308","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T3307","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T3306","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T3305","span":{"begin":0,"end":45},"obj":"Protein"}],"relations":[{"id":"R2627","pred":"themeOf","subj":"T3305","obj":"T3325"},{"id":"R2628","pred":"themeOf","subj":"T3307","obj":"T3324"},{"id":"R2629","pred":"themeOf","subj":"T3307","obj":"T3325"},{"id":"R2630","pred":"themeOf","subj":"T3309","obj":"T3326"},{"id":"R2633","pred":"themeOf","subj":"T3314","obj":"T3327"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T3698","span":{"begin":1049,"end":1065},"obj":"Positive_regulation"},{"id":"T3665","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T3663","span":{"begin":124,"end":138},"obj":"Entity"},{"id":"T3662","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T3660","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T3654","span":{"begin":895,"end":911},"obj":"Entity"},{"id":"T3653","span":{"begin":1102,"end":1104},"obj":"Protein"},{"id":"T3650","span":{"begin":303,"end":332},"obj":"Entity"},{"id":"T3649","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T3645","span":{"begin":1049,"end":1054},"obj":"Protein"},{"id":"T3643","span":{"begin":280,"end":282},"obj":"Protein"},{"id":"T3640","span":{"begin":624,"end":626},"obj":"Protein"},{"id":"T3638","span":{"begin":74,"end":83},"obj":"Entity"},{"id":"T3637","span":{"begin":844,"end":854},"obj":"Protein"},{"id":"T3634","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T3627","span":{"begin":356,"end":373},"obj":"Entity"},{"id":"T3626","span":{"begin":420,"end":429},"obj":"Protein"},{"id":"T3625","span":{"begin":241,"end":256},"obj":"Protein"},{"id":"T3624","span":{"begin":567,"end":591},"obj":"Protein"},{"id":"T3620","span":{"begin":804,"end":843},"obj":"Entity"},{"id":"T3617","span":{"begin":183,"end":256},"obj":"Entity"},{"id":"T3614","span":{"begin":548,"end":592},"obj":"Protein"},{"id":"T3613","span":{"begin":303,"end":332},"obj":"Protein"},{"id":"T3612","span":{"begin":390,"end":406},"obj":"Entity"},{"id":"T3608","span":{"begin":755,"end":789},"obj":"Entity"},{"id":"T3601","span":{"begin":187,"end":256},"obj":"Entity"},{"id":"T3599","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T3597","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T3592","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T3588","span":{"begin":879,"end":887},"obj":"Protein"},{"id":"T3587","span":{"begin":982,"end":1030},"obj":"Entity"},{"id":"T3586","span":{"begin":0,"end":54},"obj":"Protein"},{"id":"T3585","span":{"begin":525,"end":534},"obj":"Entity"},{"id":"T3687","span":{"begin":685,"end":697},"obj":"Protein"},{"id":"T3679","span":{"begin":784,"end":789},"obj":"Protein"},{"id":"T3677","span":{"begin":722,"end":724},"obj":"Protein"}],"relations":[{"id":"R2772","pred":"themeOf","subj":"T3645","obj":"T3698"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T3472","span":{"begin":1035,"end":1045},"obj":"Positive_regulation"},{"id":"T3471","span":{"begin":1055,"end":1065},"obj":"Positive_regulation"},{"id":"T3470","span":{"begin":1049,"end":1054},"obj":"Protein"},{"id":"T3469","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T3468","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T3467","span":{"begin":844,"end":854},"obj":"Protein"},{"id":"T3466","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T3465","span":{"begin":552,"end":563},"obj":"Protein"},{"id":"T3464","span":{"begin":267,"end":276},"obj":"Positive_regulation"},{"id":"T3463","span":{"begin":390,"end":398},"obj":"Protein"},{"id":"T3462","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T3461","span":{"begin":353,"end":364},"obj":"Protein"},{"id":"T3460","span":{"begin":303,"end":332},"obj":"Protein"},{"id":"T3459","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T3458","span":{"begin":152,"end":160},"obj":"Localization"},{"id":"T3457","span":{"begin":152,"end":160},"obj":"Localization"},{"id":"T3456","span":{"begin":115,"end":123},"obj":"Localization"},{"id":"T3455","span":{"begin":115,"end":123},"obj":"Localization"},{"id":"T3454","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T3453","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T3452","span":{"begin":0,"end":45},"obj":"Protein"}],"relations":[{"id":"R2712","pred":"themeOf","subj":"T3452","obj":"T3455"},{"id":"R2713","pred":"themeOf","subj":"T3452","obj":"T3457"},{"id":"R2714","pred":"themeOf","subj":"T3453","obj":"T3456"},{"id":"R2715","pred":"themeOf","subj":"T3453","obj":"T3458"},{"id":"R2716","pred":"themeOf","subj":"T3459","obj":"T3464"},{"id":"R2718","pred":"themeOf","subj":"T3470","obj":"T3471"},{"id":"R2726","pred":"themeOf","subj":"T3471","obj":"T3472"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}

{"project":"test3","denotations":[{"id":"T1746","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T1745","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T1744","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T1743","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T1742","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T1741","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T1740","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T1739","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T1738","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T1737","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T1736","span":{"begin":152,"end":160},"obj":"Localization"},{"id":"T1735","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T1734","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T1733","span":{"begin":0,"end":45},"obj":"Protein"},{"id":"T1709","span":{"begin":879,"end":889},"obj":"Protein"},{"id":"T1708","span":{"begin":869,"end":877},"obj":"Protein"},{"id":"T1707","span":{"begin":856,"end":867},"obj":"Protein"},{"id":"T1706","span":{"begin":685,"end":689},"obj":"Protein"},{"id":"T1705","span":{"begin":461,"end":487},"obj":"Protein"},{"id":"T1704","span":{"begin":431,"end":456},"obj":"Protein"},{"id":"T1703","span":{"begin":368,"end":373},"obj":"Protein"},{"id":"T1702","span":{"begin":303,"end":308},"obj":"Protein"},{"id":"T1701","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T1700","span":{"begin":219,"end":231},"obj":"Protein"},{"id":"T1699","span":{"begin":74,"end":93},"obj":"Protein"},{"id":"T1698","span":{"begin":47,"end":52},"obj":"Protein"},{"id":"T1697","span":{"begin":0,"end":45},"obj":"Protein"}],"relations":[{"id":"R1292","pred":"themeOf","subj":"T1733","obj":"T1736"},{"id":"R1293","pred":"themeOf","subj":"T1733","obj":"T1735"},{"id":"R1294","pred":"themeOf","subj":"T1734","obj":"T1735"},{"id":"R1295","pred":"equivalentTo","subj":"T1734","obj":"T1733"},{"id":"R1296","pred":"themeOf","subj":"T1735","obj":"T1736"}],"text":"High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA."}