PMC:3218875 / 5154-5879 JSONTXT

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T3087","span":{"begin":724,"end":725},"obj":"."},{"id":"T3086","span":{"begin":717,"end":724},"obj":"NN"},{"id":"T3085","span":{"begin":713,"end":716},"obj":"DT"},{"id":"T3084","span":{"begin":710,"end":712},"obj":"IN"},{"id":"T3083","span":{"begin":697,"end":709},"obj":"NN"},{"id":"T3082","span":{"begin":693,"end":696},"obj":"DT"},{"id":"T3081","span":{"begin":690,"end":692},"obj":"IN"},{"id":"T3080","span":{"begin":680,"end":689},"obj":"JJ"},{"id":"T3079","span":{"begin":674,"end":679},"obj":"VBG"},{"id":"T3078","span":{"begin":671,"end":673},"obj":"IN"},{"id":"T3077","span":{"begin":658,"end":670},"obj":"NN"},{"id":"T3076","span":{"begin":644,"end":657},"obj":"JJ"},{"id":"T3075","span":{"begin":635,"end":643},"obj":"VB"},{"id":"T3074","span":{"begin":627,"end":634},"obj":"RB"},{"id":"T3073","span":{"begin":616,"end":626},"obj":"VBG"},{"id":"T3072","span":{"begin":612,"end":615},"obj":"NNP"},{"id":"T3071","span":{"begin":606,"end":611},"obj":"VB"},{"id":"T3070","span":{"begin":603,"end":605},"obj":"TO"},{"id":"T3069","span":{"begin":592,"end":602},"obj":"NNS"},{"id":"T3068","span":{"begin":589,"end":591},"obj":"CC"},{"id":"T3067","span":{"begin":584,"end":588},"obj":"NNS"},{"id":"T3066","span":{"begin":575,"end":583},"obj":"NN"},{"id":"T3065","span":{"begin":571,"end":574},"obj":"NNP"},{"id":"T3064","span":{"begin":565,"end":570},"obj":"VBG"},{"id":"T3063","span":{"begin":558,"end":564},"obj":"NNS"},{"id":"T3062","span":{"begin":551,"end":557},"obj":"NN"},{"id":"T3061","span":{"begin":549,"end":550},"obj":","},{"id":"T3060","span":{"begin":541,"end":549},"obj":"RB"},{"id":"T3059","span":{"begin":539,"end":540},"obj":"."},{"id":"T3058","span":{"begin":531,"end":539},"obj":"NNS"},{"id":"T3057","span":{"begin":528,"end":530},"obj":"NNP"},{"id":"T3056","span":{"begin":525,"end":527},"obj":"IN"},{"id":"T3055","span":{"begin":518,"end":524},"obj":"NNS"},{"id":"T3054","span":{"begin":509,"end":517},"obj":"JJ"},{"id":"T3053","span":{"begin":505,"end":508},"obj":"DT"},{"id":"T3052","span":{"begin":498,"end":504},"obj":"IN"},{"id":"T3051","span":{"begin":490,"end":497},"obj":"JJ"},{"id":"T3050","span":{"begin":486,"end":489},"obj":"VBP"},{"id":"T3049","span":{"begin":478,"end":485},"obj":"NNS"},{"id":"T3048","span":{"begin":467,"end":477},"obj":"JJ"},{"id":"T3047","span":{"begin":459,"end":466},"obj":"JJ"},{"id":"T3046","span":{"begin":455,"end":458},"obj":"CC"},{"id":"T3045","span":{"begin":447,"end":454},"obj":"NNS"},{"id":"T3044","span":{"begin":438,"end":446},"obj":"JJ"},{"id":"T3043","span":{"begin":435,"end":437},"obj":"NNP"},{"id":"T3042","span":{"begin":432,"end":434},"obj":"IN"},{"id":"T3041","span":{"begin":422,"end":431},"obj":"VBN"},{"id":"T3040","span":{"begin":418,"end":421},"obj":"VBP"},{"id":"T3039","span":{"begin":413,"end":417},"obj":"NNS"},{"id":"T3038","span":{"begin":411,"end":412},"obj":"."},{"id":"T3037","span":{"begin":410,"end":411},"obj":"-RRB-"},{"id":"T3036","span":{"begin":409,"end":410},"obj":"NNP"},{"id":"T3035","span":{"begin":404,"end":409},"obj":"CD"},{"id":"T3034","span":{"begin":403,"end":404},"obj":"NNP"},{"id":"T3033","span":{"begin":400,"end":402},"obj":"IN"},{"id":"T3032","span":{"begin":391,"end":399},"obj":"VBN"},{"id":"T3031","span":{"begin":390,"end":391},"obj":"-LRB-"},{"id":"T3030","span":{"begin":377,"end":389},"obj":"NN"},{"id":"T3029","span":{"begin":369,"end":376},"obj":"JJ"},{"id":"T3028","span":{"begin":359,"end":368},"obj":"JJ"},{"id":"T3027","span":{"begin":350,"end":358},"obj":"VBG"},{"id":"T3026","span":{"begin":345,"end":349},"obj":"NNS"},{"id":"T3025","span":{"begin":342,"end":344},"obj":"IN"},{"id":"T3024","span":{"begin":331,"end":341},"obj":"NNS"},{"id":"T3023","span":{"begin":321,"end":330},"obj":"NN"},{"id":"T3022","span":{"begin":318,"end":320},"obj":"IN"},{"id":"T3021","span":{"begin":309,"end":317},"obj":"VBN"},{"id":"T3020","span":{"begin":304,"end":308},"obj":"VBN"},{"id":"T3019","span":{"begin":299,"end":303},"obj":"VB"},{"id":"T3018","span":{"begin":297,"end":298},"obj":":"},{"id":"T3017","span":{"begin":291,"end":296},"obj":"NNS"},{"id":"T3016","span":{"begin":287,"end":290},"obj":"CC"},{"id":"T3015","span":{"begin":279,"end":286},"obj":"NNS"},{"id":"T3014","span":{"begin":274,"end":278},"obj":"NN"},{"id":"T3013","span":{"begin":269,"end":273},"obj":"IN"},{"id":"T3012","span":{"begin":261,"end":268},"obj":"VBN"},{"id":"T3011","span":{"begin":252,"end":260},"obj":"NNS"},{"id":"T3010","span":{"begin":249,"end":251},"obj":"IN"},{"id":"T3009","span":{"begin":243,"end":248},"obj":"NN"},{"id":"T3008","span":{"begin":241,"end":242},"obj":"DT"},{"id":"T3007","span":{"begin":239,"end":240},"obj":":"},{"id":"T3006","span":{"begin":231,"end":238},"obj":"NNS"},{"id":"T3005","span":{"begin":220,"end":230},"obj":"JJ"},{"id":"T3004","span":{"begin":217,"end":219},"obj":"IN"},{"id":"T3003","span":{"begin":210,"end":216},"obj":"NN"},{"id":"T3002","span":{"begin":199,"end":209},"obj":"VBG"},{"id":"T3001","span":{"begin":196,"end":198},"obj":"DT"},{"id":"T3000","span":{"begin":194,"end":195},"obj":","},{"id":"T2999","span":{"begin":187,"end":194},"obj":"NNS"},{"id":"T2998","span":{"begin":177,"end":186},"obj":"JJ"},{"id":"T2997","span":{"begin":174,"end":176},"obj":"TO"},{"id":"T2996","span":{"begin":165,"end":173},"obj":"NN"},{"id":"T2995","span":{"begin":162,"end":164},"obj":"IN"},{"id":"T2994","span":{"begin":160,"end":161},"obj":"."},{"id":"T2993","span":{"begin":158,"end":160},"obj":"NNP"},{"id":"T2992","span":{"begin":155,"end":157},"obj":"IN"},{"id":"T2991","span":{"begin":142,"end":154},"obj":"NN"},{"id":"T2990","span":{"begin":126,"end":141},"obj":"JJ"},{"id":"T2989","span":{"begin":117,"end":125},"obj":"VBG"},{"id":"T2988","span":{"begin":113,"end":116},"obj":"IN"},{"id":"T2987","span":{"begin":102,"end":112},"obj":"NNS"},{"id":"T2986","span":{"begin":92,"end":101},"obj":"JJ"},{"id":"T2985","span":{"begin":88,"end":91},"obj":"VBP"},{"id":"T2984","span":{"begin":84,"end":87},"obj":"CC"},{"id":"T2983","span":{"begin":75,"end":83},"obj":"NNS"},{"id":"T2982","span":{"begin":64,"end":74},"obj":"JJ"},{"id":"T2981","span":{"begin":61,"end":63},"obj":"IN"},{"id":"T2980","span":{"begin":53,"end":60},"obj":"NN"},{"id":"T2979","span":{"begin":51,"end":52},"obj":"DT"},{"id":"T2978","span":{"begin":48,"end":50},"obj":"IN"},{"id":"T2977","span":{"begin":37,"end":47},"obj":"VBN"},{"id":"T2976","span":{"begin":32,"end":36},"obj":"VBN"},{"id":"T2975","span":{"begin":27,"end":31},"obj":"VBP"},{"id":"T2974","span":{"begin":25,"end":26},"obj":"-RRB-"},{"id":"T2973","span":{"begin":21,"end":25},"obj":"NNS"},{"id":"T2972","span":{"begin":20,"end":21},"obj":"-LRB-"},{"id":"T2971","span":{"begin":10,"end":19},"obj":"NNS"},{"id":"T2970","span":{"begin":0,"end":9},"obj":"JJ"}],"relations":[{"id":"R2308","pred":"amod","subj":"T2970","obj":"T2971"},{"id":"R2310","pred":"nsubjpass","subj":"T2971","obj":"T2977"},{"id":"R2311","pred":"punct","subj":"T2972","obj":"T2971"},{"id":"R2312","pred":"appos","subj":"T2973","obj":"T2971"},{"id":"R2313","pred":"punct","subj":"T2974","obj":"T2971"},{"id":"R2315","pred":"aux","subj":"T2975","obj":"T2977"},{"id":"R2316","pred":"auxpass","subj":"T2976","obj":"T2977"},{"id":"R2317","pred":"ROOT","subj":"T2977","obj":"T2977"},{"id":"R2319","pred":"prep","subj":"T2978","obj":"T2977"},{"id":"R2320","pred":"det","subj":"T2979","obj":"T2980"},{"id":"R2322","pred":"pobj","subj":"T2980","obj":"T2978"},{"id":"R2323","pred":"prep","subj":"T2981","obj":"T2980"},{"id":"R2324","pred":"amod","subj":"T2982","obj":"T2983"},{"id":"R2325","pred":"pobj","subj":"T2983","obj":"T2981"},{"id":"R2326","pred":"cc","subj":"T2984","obj":"T2977"},{"id":"R2327","pred":"conj","subj":"T2985","obj":"T2977"},{"id":"R2329","pred":"amod","subj":"T2986","obj":"T2987"},{"id":"R2330","pred":"attr","subj":"T2987","obj":"T2985"},{"id":"R2331","pred":"prep","subj":"T2988","obj":"T2987"},{"id":"R2332","pred":"pcomp","subj":"T2989","obj":"T2988"},{"id":"R2334","pred":"amod","subj":"T2990","obj":"T2991"},{"id":"R2335","pred":"dobj","subj":"T2991","obj":"T2989"},{"id":"R2337","pred":"prep","subj":"T2992","obj":"T2991"},{"id":"R2338","pred":"pobj","subj":"T2993","obj":"T2992"},{"id":"R2339","pred":"punct","subj":"T2994","obj":"T2977"},{"id":"R2340","pred":"prep","subj":"T2995","obj":"T3021"},{"id":"R2342","pred":"pobj","subj":"T2996","obj":"T2995"},{"id":"R2343","pred":"prep","subj":"T2997","obj":"T2996"},{"id":"R2344","pred":"amod","subj":"T2998","obj":"T2999"},{"id":"R2346","pred":"pobj","subj":"T2999","obj":"T2997"},{"id":"R2347","pred":"punct","subj":"T3000","obj":"T2999"},{"id":"R2349","pred":"det","subj":"T3001","obj":"T3003"},{"id":"R2350","pred":"amod","subj":"T3002","obj":"T3003"},{"id":"R2351","pred":"appos","subj":"T3003","obj":"T2999"},{"id":"R2353","pred":"prep","subj":"T3004","obj":"T3003"},{"id":"R2354","pred":"amod","subj":"T3005","obj":"T3006"},{"id":"R2355","pred":"pobj","subj":"T3006","obj":"T3004"},{"id":"R2357","pred":"punct","subj":"T3007","obj":"T3006"},{"id":"R2358","pred":"det","subj":"T3008","obj":"T3009"},{"id":"R2359","pred":"conj","subj":"T3009","obj":"T3003"},{"id":"R2361","pred":"prep","subj":"T3010","obj":"T3009"},{"id":"R2362","pred":"pobj","subj":"T3011","obj":"T3010"},{"id":"R2363","pred":"acl","subj":"T3012","obj":"T3011"},{"id":"R2365","pred":"prep","subj":"T3013","obj":"T3012"},{"id":"R2366","pred":"compound","subj":"T3014","obj":"T3015"},{"id":"R2367","pred":"pobj","subj":"T3015","obj":"T3013"},{"id":"R2369","pred":"cc","subj":"T3016","obj":"T3015"},{"id":"R2370","pred":"conj","subj":"T3017","obj":"T3015"},{"id":"R2371","pred":"punct","subj":"T3018","obj":"T3021"},{"id":"R2373","pred":"aux","subj":"T3019","obj":"T3021"},{"id":"R2376","pred":"auxpass","subj":"T3020","obj":"T3021"},{"id":"R2377","pred":"ROOT","subj":"T3021","obj":"T3021"},{"id":"R2378","pred":"prep","subj":"T3022","obj":"T3021"},{"id":"R2379","pred":"compound","subj":"T3023","obj":"T3024"},{"id":"R2381","pred":"pobj","subj":"T3024","obj":"T3022"},{"id":"R2382","pred":"prep","subj":"T3025","obj":"T3024"},{"id":"R2383","pred":"pobj","subj":"T3026","obj":"T3025"},{"id":"R2384","pred":"acl","subj":"T3027","obj":"T3024"},{"id":"R2386","pred":"amod","subj":"T3028","obj":"T3030"},{"id":"R2388","pred":"amod","subj":"T3029","obj":"T3030"},{"id":"R2389","pred":"dobj","subj":"T3030","obj":"T3027"},{"id":"R2390","pred":"punct","subj":"T3031","obj":"T3030"},{"id":"R2392","pred":"acl","subj":"T3032","obj":"T3030"},{"id":"R2394","pred":"prep","subj":"T3033","obj":"T3032"},{"id":"R2396","pred":"pobj","subj":"T3034","obj":"T3033"},{"id":"R2397","pred":"nummod","subj":"T3035","obj":"T3036"},{"id":"R2399","pred":"appos","subj":"T3036","obj":"T3034"},{"id":"R2401","pred":"punct","subj":"T3037","obj":"T3034"},{"id":"R2403","pred":"punct","subj":"T3038","obj":"T3021"},{"id":"R2404","pred":"nsubjpass","subj":"T3039","obj":"T3041"},{"id":"R2405","pred":"auxpass","subj":"T3040","obj":"T3041"},{"id":"R2407","pred":"ROOT","subj":"T3041","obj":"T3041"},{"id":"R2408","pred":"prep","subj":"T3042","obj":"T3041"},{"id":"R2409","pred":"compound","subj":"T3043","obj":"T3045"},{"id":"R2411","pred":"compound","subj":"T3044","obj":"T3045"},{"id":"R2412","pred":"pobj","subj":"T3045","obj":"T3042"},{"id":"R2414","pred":"cc","subj":"T3046","obj":"T3045"},{"id":"R2415","pred":"amod","subj":"T3047","obj":"T3049"},{"id":"R2416","pred":"amod","subj":"T3048","obj":"T3049"},{"id":"R2418","pred":"conj","subj":"T3049","obj":"T3045"},{"id":"R2419","pred":"conj","subj":"T3050","obj":"T3041"},{"id":"R2421","pred":"acomp","subj":"T3051","obj":"T3050"},{"id":"R2422","pred":"prep","subj":"T3052","obj":"T3050"},{"id":"R2423","pred":"det","subj":"T3053","obj":"T3055"},{"id":"R2424","pred":"amod","subj":"T3054","obj":"T3055"},{"id":"R2426","pred":"pobj","subj":"T3055","obj":"T3052"},{"id":"R2427","pred":"prep","subj":"T3056","obj":"T3055"},{"id":"R2428","pred":"compound","subj":"T3057","obj":"T3058"},{"id":"R2429","pred":"pobj","subj":"T3058","obj":"T3056"},{"id":"R2430","pred":"punct","subj":"T3059","obj":"T3041"},{"id":"R2431","pred":"advmod","subj":"T3060","obj":"T3075"},{"id":"R2433","pred":"punct","subj":"T3061","obj":"T3075"},{"id":"R2434","pred":"compound","subj":"T3062","obj":"T3063"},{"id":"R2435","pred":"nsubj","subj":"T3063","obj":"T3075"},{"id":"R2437","pred":"acl","subj":"T3064","obj":"T3063"},{"id":"R2438","pred":"compound","subj":"T3065","obj":"T3067"},{"id":"R2439","pred":"compound","subj":"T3066","obj":"T3067"},{"id":"R2441","pred":"dobj","subj":"T3067","obj":"T3064"},{"id":"R2442","pred":"cc","subj":"T3068","obj":"T3067"},{"id":"R2443","pred":"conj","subj":"T3069","obj":"T3067"},{"id":"R2445","pred":"aux","subj":"T3070","obj":"T3071"},{"id":"R2446","pred":"xcomp","subj":"T3071","obj":"T3064"},{"id":"R2447","pred":"dobj","subj":"T3072","obj":"T3071"},{"id":"R2448","pred":"conj","subj":"T3073","obj":"T3064"},{"id":"R2450","pred":"advmod","subj":"T3074","obj":"T3075"},{"id":"R2451","pred":"ROOT","subj":"T3075","obj":"T3075"},{"id":"R2452","pred":"amod","subj":"T3076","obj":"T3077"},{"id":"R2454","pred":"dobj","subj":"T3077","obj":"T3075"},{"id":"R2455","pred":"prep","subj":"T3078","obj":"T3075"},{"id":"R2456","pred":"pcomp","subj":"T3079","obj":"T3078"},{"id":"R2458","pred":"acomp","subj":"T3080","obj":"T3079"},{"id":"R2459","pred":"prep","subj":"T3081","obj":"T3079"},{"id":"R2460","pred":"det","subj":"T3082","obj":"T3083"},{"id":"R2462","pred":"pobj","subj":"T3083","obj":"T3081"},{"id":"R2463","pred":"prep","subj":"T3084","obj":"T3083"},{"id":"R2464","pred":"det","subj":"T3085","obj":"T3086"},{"id":"R2466","pred":"pobj","subj":"T3086","obj":"T3084"},{"id":"R2467","pred":"punct","subj":"T3087","obj":"T3075"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"2_test","denotations":[{"id":"21639951-19772831-4289441","span":{"begin":404,"end":406},"obj":"19772831"},{"id":"21639951-20629986-4289442","span":{"begin":407,"end":409},"obj":"20629986"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"pmc-enju-pas","denotations":[{"id":"T2311","span":{"begin":717,"end":724},"obj":"NN"},{"id":"T2310","span":{"begin":713,"end":716},"obj":"DT"},{"id":"T2309","span":{"begin":710,"end":712},"obj":"IN"},{"id":"T2308","span":{"begin":697,"end":709},"obj":"NN"},{"id":"T2307","span":{"begin":693,"end":696},"obj":"DT"},{"id":"T2306","span":{"begin":690,"end":692},"obj":"IN"},{"id":"T2305","span":{"begin":680,"end":689},"obj":"JJ"},{"id":"T2304","span":{"begin":674,"end":679},"obj":"VB"},{"id":"T2303","span":{"begin":671,"end":673},"obj":"IN"},{"id":"T2302","span":{"begin":658,"end":670},"obj":"NN"},{"id":"T2301","span":{"begin":644,"end":657},"obj":"JJ"},{"id":"T2300","span":{"begin":635,"end":643},"obj":"VB"},{"id":"T2299","span":{"begin":627,"end":634},"obj":"RB"},{"id":"T2298","span":{"begin":616,"end":626},"obj":"NN"},{"id":"T2297","span":{"begin":612,"end":615},"obj":"NN"},{"id":"T2296","span":{"begin":606,"end":611},"obj":"VB"},{"id":"T2295","span":{"begin":603,"end":605},"obj":"TO"},{"id":"T2294","span":{"begin":592,"end":602},"obj":"NN"},{"id":"T2293","span":{"begin":589,"end":591},"obj":"CC"},{"id":"T2292","span":{"begin":584,"end":588},"obj":"NN"},{"id":"T2291","span":{"begin":575,"end":583},"obj":"NN"},{"id":"T2290","span":{"begin":571,"end":574},"obj":"NN"},{"id":"T2289","span":{"begin":565,"end":570},"obj":"VB"},{"id":"T2288","span":{"begin":558,"end":564},"obj":"NN"},{"id":"T2287","span":{"begin":551,"end":557},"obj":"NN"},{"id":"T2286","span":{"begin":549,"end":550},"obj":"-COMMA-"},{"id":"T2285","span":{"begin":541,"end":549},"obj":"RB"},{"id":"T2284","span":{"begin":531,"end":539},"obj":"NN"},{"id":"T2283","span":{"begin":528,"end":530},"obj":"NN"},{"id":"T2282","span":{"begin":525,"end":527},"obj":"IN"},{"id":"T2281","span":{"begin":518,"end":524},"obj":"NN"},{"id":"T2280","span":{"begin":509,"end":517},"obj":"JJ"},{"id":"T2279","span":{"begin":505,"end":508},"obj":"DT"},{"id":"T2278","span":{"begin":498,"end":504},"obj":"IN"},{"id":"T2277","span":{"begin":490,"end":497},"obj":"JJ"},{"id":"T2276","span":{"begin":486,"end":489},"obj":"VB"},{"id":"T2275","span":{"begin":478,"end":485},"obj":"NN"},{"id":"T2274","span":{"begin":467,"end":477},"obj":"JJ"},{"id":"T2273","span":{"begin":459,"end":466},"obj":"JJ"},{"id":"T2272","span":{"begin":455,"end":458},"obj":"CC"},{"id":"T2237","span":{"begin":249,"end":251},"obj":"IN"},{"id":"T2236","span":{"begin":243,"end":248},"obj":"NN"},{"id":"T2235","span":{"begin":241,"end":242},"obj":"DT"},{"id":"T2234","span":{"begin":239,"end":240},"obj":"-COLON-"},{"id":"T2233","span":{"begin":231,"end":238},"obj":"NN"},{"id":"T2232","span":{"begin":220,"end":230},"obj":"JJ"},{"id":"T2231","span":{"begin":217,"end":219},"obj":"IN"},{"id":"T2230","span":{"begin":210,"end":216},"obj":"NN"},{"id":"T2229","span":{"begin":199,"end":209},"obj":"VB"},{"id":"T2228","span":{"begin":196,"end":198},"obj":"DT"},{"id":"T2227","span":{"begin":194,"end":195},"obj":"-COMMA-"},{"id":"T2226","span":{"begin":187,"end":194},"obj":"NN"},{"id":"T2225","span":{"begin":177,"end":186},"obj":"JJ"},{"id":"T2224","span":{"begin":174,"end":176},"obj":"TO"},{"id":"T2223","span":{"begin":165,"end":173},"obj":"NN"},{"id":"T2222","span":{"begin":162,"end":164},"obj":"IN"},{"id":"T2221","span":{"begin":158,"end":160},"obj":"NN"},{"id":"T2220","span":{"begin":155,"end":157},"obj":"IN"},{"id":"T2219","span":{"begin":142,"end":154},"obj":"NN"},{"id":"T2218","span":{"begin":126,"end":141},"obj":"JJ"},{"id":"T2217","span":{"begin":117,"end":125},"obj":"VB"},{"id":"T2216","span":{"begin":113,"end":116},"obj":"IN"},{"id":"T2215","span":{"begin":102,"end":112},"obj":"NN"},{"id":"T2214","span":{"begin":92,"end":101},"obj":"JJ"},{"id":"T2213","span":{"begin":88,"end":91},"obj":"VB"},{"id":"T2212","span":{"begin":84,"end":87},"obj":"CC"},{"id":"T2211","span":{"begin":75,"end":83},"obj":"NN"},{"id":"T2210","span":{"begin":64,"end":74},"obj":"JJ"},{"id":"T2209","span":{"begin":61,"end":63},"obj":"IN"},{"id":"T2208","span":{"begin":53,"end":60},"obj":"NN"},{"id":"T2207","span":{"begin":51,"end":52},"obj":"DT"},{"id":"T2206","span":{"begin":48,"end":50},"obj":"IN"},{"id":"T2205","span":{"begin":37,"end":47},"obj":"VB"},{"id":"T2204","span":{"begin":32,"end":36},"obj":"VB"},{"id":"T2203","span":{"begin":27,"end":31},"obj":"VB"},{"id":"T2202","span":{"begin":25,"end":26},"obj":"-RRB-"},{"id":"T2201","span":{"begin":21,"end":25},"obj":"NN"},{"id":"T2200","span":{"begin":20,"end":21},"obj":"-LRB-"},{"id":"T2199","span":{"begin":10,"end":19},"obj":"NN"},{"id":"T2198","span":{"begin":0,"end":9},"obj":"JJ"},{"id":"T2271","span":{"begin":447,"end":454},"obj":"NN"},{"id":"T2270","span":{"begin":438,"end":446},"obj":"JJ"},{"id":"T2269","span":{"begin":435,"end":437},"obj":"NN"},{"id":"T2268","span":{"begin":432,"end":434},"obj":"IN"},{"id":"T2267","span":{"begin":422,"end":431},"obj":"VB"},{"id":"T2266","span":{"begin":418,"end":421},"obj":"VB"},{"id":"T2265","span":{"begin":413,"end":417},"obj":"NN"},{"id":"T2264","span":{"begin":410,"end":411},"obj":"-RRB-"},{"id":"T2263","span":{"begin":409,"end":410},"obj":"-RRB-"},{"id":"T2262","span":{"begin":404,"end":409},"obj":"CD"},{"id":"T2261","span":{"begin":403,"end":404},"obj":"-LRB-"},{"id":"T2260","span":{"begin":400,"end":402},"obj":"IN"},{"id":"T2259","span":{"begin":391,"end":399},"obj":"VB"},{"id":"T2258","span":{"begin":390,"end":391},"obj":"-LRB-"},{"id":"T2257","span":{"begin":377,"end":389},"obj":"NN"},{"id":"T2256","span":{"begin":369,"end":376},"obj":"JJ"},{"id":"T2255","span":{"begin":359,"end":368},"obj":"JJ"},{"id":"T2254","span":{"begin":350,"end":358},"obj":"VB"},{"id":"T2253","span":{"begin":345,"end":349},"obj":"NN"},{"id":"T2252","span":{"begin":342,"end":344},"obj":"IN"},{"id":"T2251","span":{"begin":331,"end":341},"obj":"NN"},{"id":"T2250","span":{"begin":321,"end":330},"obj":"NN"},{"id":"T2249","span":{"begin":318,"end":320},"obj":"IN"},{"id":"T2248","span":{"begin":309,"end":317},"obj":"VB"},{"id":"T2247","span":{"begin":304,"end":308},"obj":"VB"},{"id":"T2246","span":{"begin":299,"end":303},"obj":"VB"},{"id":"T2245","span":{"begin":297,"end":298},"obj":"-COLON-"},{"id":"T2244","span":{"begin":291,"end":296},"obj":"NN"},{"id":"T2243","span":{"begin":287,"end":290},"obj":"CC"},{"id":"T2242","span":{"begin":279,"end":286},"obj":"NN"},{"id":"T2241","span":{"begin":274,"end":278},"obj":"NN"},{"id":"T2240","span":{"begin":269,"end":273},"obj":"IN"},{"id":"T2239","span":{"begin":261,"end":268},"obj":"VB"},{"id":"T2238","span":{"begin":252,"end":260},"obj":"NN"}],"relations":[{"id":"R1681","pred":"arg1Of","subj":"T2199","obj":"T2198"},{"id":"R1682","pred":"arg1Of","subj":"T2199","obj":"T2200"},{"id":"R1683","pred":"arg1Of","subj":"T2199","obj":"T2203"},{"id":"R1684","pred":"arg1Of","subj":"T2199","obj":"T2204"},{"id":"R1685","pred":"arg2Of","subj":"T2199","obj":"T2205"},{"id":"R1686","pred":"arg1Of","subj":"T2199","obj":"T2213"},{"id":"R1687","pred":"arg2Of","subj":"T2201","obj":"T2200"},{"id":"R1688","pred":"arg3Of","subj":"T2202","obj":"T2200"},{"id":"R1689","pred":"arg2Of","subj":"T2205","obj":"T2203"},{"id":"R1690","pred":"arg2Of","subj":"T2205","obj":"T2204"},{"id":"R1691","pred":"arg1Of","subj":"T2205","obj":"T2206"},{"id":"R1692","pred":"arg1Of","subj":"T2205","obj":"T2212"},{"id":"R1693","pred":"arg2Of","subj":"T2208","obj":"T2206"},{"id":"R1694","pred":"arg1Of","subj":"T2208","obj":"T2207"},{"id":"R1695","pred":"arg1Of","subj":"T2208","obj":"T2209"},{"id":"R1696","pred":"arg2Of","subj":"T2211","obj":"T2209"},{"id":"R1697","pred":"arg1Of","subj":"T2211","obj":"T2210"},{"id":"R1698","pred":"arg2Of","subj":"T2213","obj":"T2212"},{"id":"R1699","pred":"arg2Of","subj":"T2215","obj":"T2213"},{"id":"R1700","pred":"arg1Of","subj":"T2215","obj":"T2214"},{"id":"R1701","pred":"arg1Of","subj":"T2215","obj":"T2216"},{"id":"R1702","pred":"arg2Of","subj":"T2217","obj":"T2216"},{"id":"R1703","pred":"arg1Of","subj":"T2217","obj":"T2220"},{"id":"R1704","pred":"arg2Of","subj":"T2219","obj":"T2217"},{"id":"R1705","pred":"arg1Of","subj":"T2219","obj":"T2218"},{"id":"R1706","pred":"arg2Of","subj":"T2221","obj":"T2220"},{"id":"R1707","pred":"arg2Of","subj":"T2223","obj":"T2222"},{"id":"R1708","pred":"arg1Of","subj":"T2223","obj":"T2224"},{"id":"R1709","pred":"arg2Of","subj":"T2226","obj":"T2224"},{"id":"R1710","pred":"arg1Of","subj":"T2226","obj":"T2225"},{"id":"R1711","pred":"arg1Of","subj":"T2230","obj":"T2228"},{"id":"R1712","pred":"arg1Of","subj":"T2230","obj":"T2229"},{"id":"R1713","pred":"arg1Of","subj":"T2230","obj":"T2231"},{"id":"R1714","pred":"arg1Of","subj":"T2230","obj":"T2234"},{"id":"R1715","pred":"arg1Of","subj":"T2230","obj":"T2246"},{"id":"R1716","pred":"arg1Of","subj":"T2230","obj":"T2247"},{"id":"R1717","pred":"arg2Of","subj":"T2230","obj":"T2248"},{"id":"R1718","pred":"arg2Of","subj":"T2233","obj":"T2231"},{"id":"R1719","pred":"arg1Of","subj":"T2233","obj":"T2232"},{"id":"R1720","pred":"arg2Of","subj":"T2236","obj":"T2234"},{"id":"R1721","pred":"arg1Of","subj":"T2236","obj":"T2235"},{"id":"R1722","pred":"arg1Of","subj":"T2236","obj":"T2237"},{"id":"R1723","pred":"arg2Of","subj":"T2238","obj":"T2237"},{"id":"R1724","pred":"arg2Of","subj":"T2238","obj":"T2239"},{"id":"R1725","pred":"arg1Of","subj":"T2239","obj":"T2240"},{"id":"R1726","pred":"arg1Of","subj":"T2242","obj":"T2241"},{"id":"R1727","pred":"arg1Of","subj":"T2242","obj":"T2243"},{"id":"R1728","pred":"arg2Of","subj":"T2243","obj":"T2240"},{"id":"R1729","pred":"arg2Of","subj":"T2244","obj":"T2243"},{"id":"R1730","pred":"arg1Of","subj":"T2244","obj":"T2245"},{"id":"R1731","pred":"arg1Of","subj":"T2248","obj":"T2222"},{"id":"R1732","pred":"arg1Of","subj":"T2248","obj":"T2227"},{"id":"R1733","pred":"arg2Of","subj":"T2248","obj":"T2246"},{"id":"R1734","pred":"arg2Of","subj":"T2248","obj":"T2247"},{"id":"R1735","pred":"arg1Of","subj":"T2248","obj":"T2249"},{"id":"R1736","pred":"arg2Of","subj":"T2251","obj":"T2249"},{"id":"R1737","pred":"arg1Of","subj":"T2251","obj":"T2250"},{"id":"R1738","pred":"arg1Of","subj":"T2251","obj":"T2252"},{"id":"R1739","pred":"arg2Of","subj":"T2253","obj":"T2252"},{"id":"R1740","pred":"arg1Of","subj":"T2253","obj":"T2254"},{"id":"R1741","pred":"arg2Of","subj":"T2257","obj":"T2254"},{"id":"R1742","pred":"arg1Of","subj":"T2257","obj":"T2255"},{"id":"R1743","pred":"arg1Of","subj":"T2257","obj":"T2256"},{"id":"R1744","pred":"arg1Of","subj":"T2257","obj":"T2258"},{"id":"R1745","pred":"arg2Of","subj":"T2259","obj":"T2258"},{"id":"R1746","pred":"arg1Of","subj":"T2259","obj":"T2260"},{"id":"R1747","pred":"arg1Of","subj":"T2259","obj":"T2261"},{"id":"R1748","pred":"arg2Of","subj":"T2262","obj":"T2261"},{"id":"R1749","pred":"arg3Of","subj":"T2263","obj":"T2261"},{"id":"R1750","pred":"arg3Of","subj":"T2264","obj":"T2258"},{"id":"R1751","pred":"arg1Of","subj":"T2265","obj":"T2266"},{"id":"R1752","pred":"arg2Of","subj":"T2265","obj":"T2267"},{"id":"R1753","pred":"arg2Of","subj":"T2267","obj":"T2266"},{"id":"R1754","pred":"arg1Of","subj":"T2267","obj":"T2268"},{"id":"R1755","pred":"arg2Of","subj":"T2269","obj":"T2268"},{"id":"R1756","pred":"arg1Of","subj":"T2271","obj":"T2270"},{"id":"R1757","pred":"arg1Of","subj":"T2271","obj":"T2272"},{"id":"R1758","pred":"arg1Of","subj":"T2272","obj":"T2276"},{"id":"R1759","pred":"arg1Of","subj":"T2272","obj":"T2277"},{"id":"R1760","pred":"arg2Of","subj":"T2275","obj":"T2272"},{"id":"R1761","pred":"arg1Of","subj":"T2275","obj":"T2273"},{"id":"R1762","pred":"arg1Of","subj":"T2275","obj":"T2274"},{"id":"R1763","pred":"modOf","subj":"T2276","obj":"T2266"},{"id":"R1764","pred":"arg2Of","subj":"T2277","obj":"T2276"},{"id":"R1765","pred":"arg1Of","subj":"T2277","obj":"T2278"},{"id":"R1766","pred":"arg2Of","subj":"T2281","obj":"T2278"},{"id":"R1767","pred":"arg1Of","subj":"T2281","obj":"T2279"},{"id":"R1768","pred":"arg1Of","subj":"T2281","obj":"T2280"},{"id":"R1769","pred":"arg1Of","subj":"T2281","obj":"T2282"},{"id":"R1770","pred":"arg2Of","subj":"T2284","obj":"T2282"},{"id":"R1771","pred":"arg1Of","subj":"T2284","obj":"T2283"},{"id":"R1772","pred":"arg1Of","subj":"T2288","obj":"T2287"},{"id":"R1773","pred":"arg1Of","subj":"T2288","obj":"T2289"},{"id":"R1774","pred":"arg1Of","subj":"T2288","obj":"T2300"},{"id":"R1775","pred":"arg1Of","subj":"T2292","obj":"T2290"},{"id":"R1776","pred":"arg1Of","subj":"T2292","obj":"T2291"},{"id":"R1777","pred":"arg1Of","subj":"T2292","obj":"T2293"},{"id":"R1778","pred":"arg2Of","subj":"T2293","obj":"T2289"},{"id":"R1779","pred":"arg2Of","subj":"T2294","obj":"T2293"},{"id":"R1780","pred":"modOf","subj":"T2294","obj":"T2295"},{"id":"R1781","pred":"arg1Of","subj":"T2296","obj":"T2295"},{"id":"R1782","pred":"arg2Of","subj":"T2298","obj":"T2296"},{"id":"R1783","pred":"arg1Of","subj":"T2298","obj":"T2297"},{"id":"R1784","pred":"arg1Of","subj":"T2300","obj":"T2285"},{"id":"R1785","pred":"arg1Of","subj":"T2300","obj":"T2286"},{"id":"R1786","pred":"arg1Of","subj":"T2300","obj":"T2299"},{"id":"R1787","pred":"arg1Of","subj":"T2300","obj":"T2303"},{"id":"R1788","pred":"arg2Of","subj":"T2302","obj":"T2300"},{"id":"R1789","pred":"arg1Of","subj":"T2302","obj":"T2301"},{"id":"R1790","pred":"arg2Of","subj":"T2304","obj":"T2303"},{"id":"R1791","pred":"arg1Of","subj":"T2304","obj":"T2306"},{"id":"R1792","pred":"arg2Of","subj":"T2305","obj":"T2304"},{"id":"R1793","pred":"arg2Of","subj":"T2308","obj":"T2306"},{"id":"R1794","pred":"arg1Of","subj":"T2308","obj":"T2307"},{"id":"R1795","pred":"arg1Of","subj":"T2308","obj":"T2309"},{"id":"R1796","pred":"arg2Of","subj":"T2311","obj":"T2309"},{"id":"R1797","pred":"arg1Of","subj":"T2311","obj":"T2310"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"UBERON-AE","denotations":[{"id":"T1750","span":{"begin":447,"end":454},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T1749","span":{"begin":279,"end":286},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"GO-BP","denotations":[{"id":"T2512","span":{"begin":697,"end":709},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T2505","span":{"begin":616,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T2494","span":{"begin":658,"end":670},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2493","span":{"begin":377,"end":389},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2492","span":{"begin":142,"end":154},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"GO-MF","denotations":[{"id":"T2522","span":{"begin":478,"end":485},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T2521","span":{"begin":231,"end":238},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T2520","span":{"begin":187,"end":194},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"GO-CC","denotations":[{"id":"T2541","span":{"begin":274,"end":278},"obj":"http://purl.obolibrary.org/obo/GO_0018995"},{"id":"T2533","span":{"begin":291,"end":296},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"sentences","denotations":[{"id":"T1767","span":{"begin":541,"end":725},"obj":"Sentence"},{"id":"T1766","span":{"begin":413,"end":540},"obj":"Sentence"},{"id":"T1765","span":{"begin":162,"end":412},"obj":"Sentence"},{"id":"T1764","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T29","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T30","span":{"begin":162,"end":412},"obj":"Sentence"},{"id":"T31","span":{"begin":413,"end":540},"obj":"Sentence"},{"id":"T32","span":{"begin":541,"end":725},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T3696","span":{"begin":252,"end":278},"obj":"Gene_expression"},{"id":"T3692","span":{"begin":0,"end":83},"obj":"Gene_expression"},{"id":"T3691","span":{"begin":459,"end":485},"obj":"Entity"},{"id":"T3688","span":{"begin":435,"end":437},"obj":"Protein"},{"id":"T3652","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T3648","span":{"begin":321,"end":341},"obj":"Entity"},{"id":"T3647","span":{"begin":528,"end":530},"obj":"Protein"},{"id":"T3646","span":{"begin":252,"end":278},"obj":"Protein"},{"id":"T3629","span":{"begin":177,"end":195},"obj":"Entity"},{"id":"T3622","span":{"begin":158,"end":160},"obj":"Protein"},{"id":"T3619","span":{"begin":345,"end":389},"obj":"Protein"},{"id":"T3598","span":{"begin":0,"end":26},"obj":"Protein"},{"id":"T3594","span":{"begin":126,"end":141},"obj":"Protein"},{"id":"T3593","span":{"begin":217,"end":278},"obj":"Entity"}],"relations":[{"id":"R2750","pred":"themeOf","subj":"T3598","obj":"T3692"},{"id":"R2773","pred":"themeOf","subj":"T3646","obj":"T3696"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T3451","span":{"begin":606,"end":611},"obj":"Negative_regulation"},{"id":"T3450","span":{"begin":612,"end":615},"obj":"Protein"},{"id":"T3449","span":{"begin":126,"end":131},"obj":"Protein"}],"relations":[{"id":"R2708","pred":"themeOf","subj":"T3450","obj":"T3451"}],"text":"Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease."}