PMC:3218875 / 32132-32809 JSONTXT

Annnotations TAB JSON ListView MergeView

    testone

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    bionlp-st-ge-2016-test-proteins

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    2_test

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    pmc-enju-pas

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miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]."}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T18003","span":{"begin":399,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_1904465"},{"id":"T18002","span":{"begin":399,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_1990773"},{"id":"T18001","span":{"begin":399,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_1904466"},{"id":"T18000","span":{"begin":399,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_1904464"},{"id":"T17999","span":{"begin":399,"end":408},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T17998","span":{"begin":653,"end":665},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T17988","span":{"begin":110,"end":132},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]."}

    GO-MF

    {"project":"GO-MF","denotations":[{"id":"T18006","span":{"begin":443,"end":447},"obj":"http://purl.obolibrary.org/obo/GO_0005138"},{"id":"T18005","span":{"begin":437,"end":445},"obj":"http://purl.obolibrary.org/obo/GO_0005149"}],"text":"Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]."}

    sentences

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    simple1

    {"project":"simple1","denotations":[{"id":"T18038","span":{"begin":527,"end":534},"obj":"Protein"},{"id":"T18037","span":{"begin":514,"end":521},"obj":"Protein"},{"id":"T18036","span":{"begin":506,"end":512},"obj":"Protein"},{"id":"T18035","span":{"begin":443,"end":447},"obj":"Protein"},{"id":"T18034","span":{"begin":412,"end":438},"obj":"Protein"},{"id":"T18033","span":{"begin":368,"end":375},"obj":"Protein"},{"id":"T18032","span":{"begin":236,"end":270},"obj":"Protein"},{"id":"T18031","span":{"begin":192,"end":200},"obj":"Protein"},{"id":"T18030","span":{"begin":20,"end":27},"obj":"Protein"}],"text":"Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]."}

    BioNLP16_DUT

    {"project":"BioNLP16_DUT","denotations":[{"id":"T18771","span":{"begin":527,"end":534},"obj":"Protein"},{"id":"T18770","span":{"begin":514,"end":521},"obj":"Protein"},{"id":"T18769","span":{"begin":506,"end":512},"obj":"Protein"},{"id":"T18768","span":{"begin":443,"end":447},"obj":"Protein"},{"id":"T18767","span":{"begin":412,"end":438},"obj":"Protein"},{"id":"T18766","span":{"begin":368,"end":375},"obj":"Protein"},{"id":"T18765","span":{"begin":236,"end":270},"obj":"Protein"},{"id":"T18764","span":{"begin":192,"end":200},"obj":"Protein"},{"id":"T18763","span":{"begin":20,"end":27},"obj":"Protein"},{"id":"T18785","span":{"begin":570,"end":580},"obj":"Gene_expression"},{"id":"T18784","span":{"begin":389,"end":398},"obj":"Positive_regulation"},{"id":"T18783","span":{"begin":399,"end":408},"obj":"Localization"},{"id":"T18782","span":{"begin":349,"end":357},"obj":"Positive_regulation"},{"id":"T18781","span":{"begin":289,"end":298},"obj":"Negative_regulation"}],"relations":[{"id":"R12441","pred":"themeOf","subj":"T18764","obj":"T18781"},{"id":"R12442","pred":"themeOf","subj":"T18766","obj":"T18782"},{"id":"R12443","pred":"themeOf","subj":"T18767","obj":"T18783"},{"id":"R12444","pred":"themeOf","subj":"T18768","obj":"T18783"},{"id":"R12445","pred":"themeOf","subj":"T18770","obj":"T18785"},{"id":"R12449","pred":"themeOf","subj":"T18783","obj":"T18784"},{"id":"R12450","pred":"themeOf","subj":"T18783","obj":"T18784"}],"text":"Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]."}

    BioNLP16_Messiy

    {"project":"BioNLP16_Messiy","denotations":[{"id":"T18550","span":{"begin":399,"end":408},"obj":"Localization"},{"id":"T18549","span":{"begin":349,"end":357},"obj":"Positive_regulation"},{"id":"T18548","span":{"begin":389,"end":398},"obj":"Positive_regulation"},{"id":"T18547","span":{"begin":289,"end":298},"obj":"Negative_regulation"},{"id":"T18538","span":{"begin":527,"end":534},"obj":"Protein"},{"id":"T18537","span":{"begin":514,"end":521},"obj":"Protein"},{"id":"T18536","span":{"begin":506,"end":512},"obj":"Protein"},{"id":"T18535","span":{"begin":443,"end":447},"obj":"Protein"},{"id":"T18534","span":{"begin":412,"end":438},"obj":"Protein"},{"id":"T18533","span":{"begin":368,"end":375},"obj":"Protein"},{"id":"T18532","span":{"begin":236,"end":270},"obj":"Protein"},{"id":"T18531","span":{"begin":192,"end":200},"obj":"Protein"},{"id":"T18530","span":{"begin":20,"end":27},"obj":"Protein"}],"relations":[{"id":"R12365","pred":"themeOf","subj":"T18531","obj":"T18547"},{"id":"R12366","pred":"themeOf","subj":"T18533","obj":"T18549"},{"id":"R12367","pred":"themeOf","subj":"T18534","obj":"T18548"},{"id":"R12368","pred":"themeOf","subj":"T18534","obj":"T18550"},{"id":"R12369","pred":"themeOf","subj":"T18535","obj":"T18548"},{"id":"R12370","pred":"themeOf","subj":"T18535","obj":"T18550"},{"id":"R12372","pred":"themeOf","subj":"T18550","obj":"T18548"},{"id":"R12373","pred":"themeOf","subj":"T18550","obj":"T18548"}],"text":"Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]."}

    bionlp-st-ge-2016-test-ihmc

    {"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T18859","span":{"begin":386,"end":447},"obj":"Gene_expression"},{"id":"T18858","span":{"begin":386,"end":447},"obj":"Gene_expression"},{"id":"T18855","span":{"begin":386,"end":447},"obj":"Positive_regulation"},{"id":"T18854","span":{"begin":386,"end":447},"obj":"Positive_regulation"},{"id":"T18850","span":{"begin":443,"end":447},"obj":"Protein"},{"id":"T18849","span":{"begin":320,"end":322},"obj":"Protein"},{"id":"T18848","span":{"begin":226,"end":235},"obj":"Protein"},{"id":"T18846","span":{"begin":467,"end":469},"obj":"Protein"},{"id":"T18842","span":{"begin":8,"end":15},"obj":"Entity"},{"id":"T18840","span":{"begin":302,"end":314},"obj":"Entity"},{"id":"T18837","span":{"begin":506,"end":512},"obj":"Protein"},{"id":"T18823","span":{"begin":527,"end":534},"obj":"Protein"},{"id":"T18820","span":{"begin":192,"end":200},"obj":"Protein"},{"id":"T18819","span":{"begin":584,"end":586},"obj":"Protein"},{"id":"T18817","span":{"begin":412,"end":438},"obj":"Protein"},{"id":"T18808","span":{"begin":136,"end":148},"obj":"Protein"},{"id":"T18803","span":{"begin":514,"end":521},"obj":"Protein"},{"id":"T18800","span":{"begin":479,"end":495},"obj":"Entity"},{"id":"T18799","span":{"begin":222,"end":270},"obj":"Protein"},{"id":"T18798","span":{"begin":368,"end":375},"obj":"Protein"},{"id":"T18793","span":{"begin":94,"end":109},"obj":"Protein"},{"id":"T18790","span":{"begin":20,"end":28},"obj":"Protein"}],"relations":[{"id":"R12453","pred":"themeOf","subj":"T18817","obj":"T18858"},{"id":"R12461","pred":"themeOf","subj":"T18850","obj":"T18859"},{"id":"R12462","pred":"themeOf","subj":"T18858","obj":"T18854"},{"id":"R12463","pred":"themeOf","subj":"T18859","obj":"T18855"}],"text":"Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]."}

    bionlp-st-ge-2016-test-tees

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    test3

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