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(CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63]. CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]). CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1. Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation. As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling. In addition, their relative activity might also be cell-type dependent [64]."}

{"project":"GO-BP","denotations":[{"id":"T14590","span":{"begin":702,"end":718},"obj":"http://purl.obolibrary.org/obo/GO_0051092"},{"id":"T14587","span":{"begin":924,"end":934},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T14586","span":{"begin":861,"end":871},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T14585","span":{"begin":515,"end":525},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T14584","span":{"begin":382,"end":392},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T14583","span":{"begin":326,"end":349},"obj":"http://purl.obolibrary.org/obo/GO_0004843"},{"id":"T14582","span":{"begin":256,"end":271},"obj":"http://purl.obolibrary.org/obo/GO_0007283"},{"id":"T14581","span":{"begin":232,"end":254},"obj":"http://purl.obolibrary.org/obo/GO_0051726"},{"id":"T14580","span":{"begin":232,"end":254},"obj":"http://purl.obolibrary.org/obo/GO_0007050"},{"id":"T14579","span":{"begin":232,"end":242},"obj":"http://purl.obolibrary.org/obo/GO_0007049"},{"id":"T14578","span":{"begin":216,"end":228},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Cylindromatosis (CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63]. CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]). CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1. Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation. As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling. In addition, their relative activity might also be cell-type dependent [64]."}

{"project":"GO-MF","denotations":[{"id":"T14596","span":{"begin":326,"end":349},"obj":"http://purl.obolibrary.org/obo/GO_0004843"}],"text":"Cylindromatosis (CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63]. CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]). CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1. Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation. As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling. In addition, their relative activity might also be cell-type dependent [64]."}

{"project":"GO-CC","denotations":[{"id":"T14604","span":{"begin":987,"end":991},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14603","span":{"begin":753,"end":757},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14602","span":{"begin":660,"end":664},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14601","span":{"begin":423,"end":427},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14600","span":{"begin":232,"end":236},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Cylindromatosis (CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63]. CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]). CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1. Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation. As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling. In addition, their relative activity might also be cell-type dependent [64]."}

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