PMC:3216508 / 13095-14111 JSONTXT

{"project":"2_test","denotations":[{"id":"22355539-16381902-135382461","span":{"begin":408,"end":410},"obj":"16381902"},{"id":"22355539-18957442-135382462","span":{"begin":456,"end":458},"obj":"18957442"},{"id":"22355539-18541913-135382463","span":{"begin":456,"end":460},"obj":"18541913"},{"id":"22355539-15735639-135382464","span":{"begin":793,"end":795},"obj":"15735639"},{"id":"22355539-2166701-135382465","span":{"begin":939,"end":941},"obj":"2166701"},{"id":"22355539-10601325-135382466","span":{"begin":1013,"end":1015},"obj":"10601325"}],"text":"The SNPs we found are biologically meaningful. The SNP rs2227473 alters the putative binding sites of several transcription factors from multiple databases, including Cgd2_3490 and PF14_0633, from the UniPROBE database, and RCGCANGCGY, and TCCCRNNRTG from the Jaspar database. Both Cgd2_3490 and PF14_0633 are hypothetical transcription factors containing AP2 domain. Cgd2_3490 is from Cryptosporidium parvum2021 and PF14_0633 is from Plasmodium falciparum222324. We propose that the two proteins from pathogens can target the host genes and regulate IL-22's expression. The variations in the binding sites of the two proteins provide a differential way of regulation. The two motifs, RCGCANGCGY and TCCCRNNRTG, were discovered by scanning the promoters of all human genes for conserved motifs25. RCGCANGCGY matches the binding consensus of transcription factor NRF1 (nuclear respiratory factor 1), which binds to the cytochrome c promotor26, and is essential for cell survival in oxidative stress inducing agents27."}