PMC:3148254 / 9621-10238 JSONTXT

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Figure 2 CD40-mediated CD80 upregulation is defective in HOIP-deficient cells.\nCells were incubated for 72 hrs with an isotype control antibody (left) or anti-CD40 antibody (right) and then stained for expression of CD80 (filled profiles indicate staining with anti-CD80 antibody; open profiles are staining with an isotype control antibody). Transduction of both HOIP-deficient (HOIP-/-) clones with a retrovirus encoding FLAG-HOIP reversed defective CD80 upregulation, while transduction with an empty vector (pMIP) did not. Similar results were obtained in a second experiment. "}

{"project":"GO-BP","denotations":[{"id":"T15595","span":{"begin":378,"end":390},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T15596","span":{"begin":512,"end":524},"obj":"http://purl.obolibrary.org/obo/GO_0009293"}],"text":"10.1371/journal.pone.0023061.g002 Figure 2 CD40-mediated CD80 upregulation is defective in HOIP-deficient cells.\nCells were incubated for 72 hrs with an isotype control antibody (left) or anti-CD40 antibody (right) and then stained for expression of CD80 (filled profiles indicate staining with anti-CD80 antibody; open profiles are staining with an isotype control antibody). Transduction of both HOIP-deficient (HOIP-/-) clones with a retrovirus encoding FLAG-HOIP reversed defective CD80 upregulation, while transduction with an empty vector (pMIP) did not. Similar results were obtained in a second experiment. "}

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