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Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.\nCD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP). Cells were activated with CD154-expressing insect cells for the times indicated. As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only). Western blots of whole-cell lysates were probed with the indicated antibodies. Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms). IκBα blots were also reprobed for actin to demonstrate equal lane loading. Molecular weights are indicated at right. Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.\n\n"}

{"project":"GO-BP","denotations":[{"id":"T16565","span":{"begin":57,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0051092"},{"id":"T16566","span":{"begin":81,"end":84},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16567","span":{"begin":685,"end":688},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16568","span":{"begin":754,"end":757},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16569","span":{"begin":778,"end":781},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16570","span":{"begin":137,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"10.1371/journal.pone.0023061.g004 Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.\nCD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP). Cells were activated with CD154-expressing insect cells for the times indicated. As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only). Western blots of whole-cell lysates were probed with the indicated antibodies. Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms). IκBα blots were also reprobed for actin to demonstrate equal lane loading. Molecular weights are indicated at right. Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.\n\n"}

{"project":"GO-MF","denotations":[{"id":"T16571","span":{"begin":81,"end":84},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16572","span":{"begin":685,"end":688},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16573","span":{"begin":754,"end":757},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16574","span":{"begin":778,"end":781},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T16575","span":{"begin":640,"end":650},"obj":"http://purl.obolibrary.org/obo/GO_0003823"},{"id":"T16576","span":{"begin":782,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0003823"}],"text":"10.1371/journal.pone.0023061.g004 Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.\nCD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP). Cells were activated with CD154-expressing insect cells for the times indicated. As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only). Western blots of whole-cell lysates were probed with the indicated antibodies. Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms). IκBα blots were also reprobed for actin to demonstrate equal lane loading. Molecular weights are indicated at right. Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.\n\n"}

{"project":"GO-CC","denotations":[{"id":"T16577","span":{"begin":116,"end":121},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16578","span":{"begin":179,"end":184},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16579","span":{"begin":226,"end":231},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16580","span":{"begin":313,"end":318},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16581","span":{"begin":437,"end":442},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16582","span":{"begin":491,"end":496},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16583","span":{"begin":525,"end":530},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16584","span":{"begin":596,"end":600},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T16585","span":{"begin":640,"end":650},"obj":"http://purl.obolibrary.org/obo/GO_0019815"},{"id":"T16586","span":{"begin":782,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0019815"},{"id":"T16587","span":{"begin":640,"end":650},"obj":"http://purl.obolibrary.org/obo/GO_0042571"},{"id":"T16588","span":{"begin":782,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0042571"}],"text":"10.1371/journal.pone.0023061.g004 Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.\nCD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP). Cells were activated with CD154-expressing insect cells for the times indicated. As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only). Western blots of whole-cell lysates were probed with the indicated antibodies. Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms). IκBα blots were also reprobed for actin to demonstrate equal lane loading. Molecular weights are indicated at right. Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.\n\n"}

{"project":"sentences","denotations":[{"id":"T16183","span":{"begin":44,"end":122},"obj":"Sentence"},{"id":"T16184","span":{"begin":123,"end":386},"obj":"Sentence"},{"id":"T16185","span":{"begin":387,"end":467},"obj":"Sentence"},{"id":"T16186","span":{"begin":468,"end":572},"obj":"Sentence"},{"id":"T16187","span":{"begin":573,"end":651},"obj":"Sentence"},{"id":"T16188","span":{"begin":652,"end":825},"obj":"Sentence"},{"id":"T16189","span":{"begin":826,"end":900},"obj":"Sentence"},{"id":"T16190","span":{"begin":901,"end":942},"obj":"Sentence"},{"id":"T16191","span":{"begin":943,"end":1065},"obj":"Sentence"},{"id":"T98","span":{"begin":0,"end":122},"obj":"Sentence"},{"id":"T99","span":{"begin":123,"end":386},"obj":"Sentence"},{"id":"T100","span":{"begin":387,"end":467},"obj":"Sentence"},{"id":"T101","span":{"begin":468,"end":572},"obj":"Sentence"},{"id":"T102","span":{"begin":573,"end":651},"obj":"Sentence"},{"id":"T103","span":{"begin":652,"end":825},"obj":"Sentence"},{"id":"T104","span":{"begin":826,"end":900},"obj":"Sentence"},{"id":"T105","span":{"begin":901,"end":942},"obj":"Sentence"},{"id":"T106","span":{"begin":943,"end":1065},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"10.1371/journal.pone.0023061.g004 Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.\nCD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP). Cells were activated with CD154-expressing insect cells for the times indicated. As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only). Western blots of whole-cell lysates were probed with the indicated antibodies. Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms). IκBα blots were also reprobed for actin to demonstrate equal lane loading. Molecular weights are indicated at right. Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.\n\n"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T16539","span":{"begin":44,"end":48},"obj":"P25942"},{"id":"T16540","span":{"begin":101,"end":105},"obj":"Q96EP0"},{"id":"T16541","span":{"begin":123,"end":127},"obj":"P25942"},{"id":"T16542","span":{"begin":164,"end":168},"obj":"Q96EP0"},{"id":"T16543","span":{"begin":186,"end":190},"obj":"Q96EP0"},{"id":"T16544","span":{"begin":276,"end":279},"obj":"P21580"},{"id":"T16545","span":{"begin":298,"end":302},"obj":"Q96EP0"},{"id":"T16546","span":{"begin":364,"end":368},"obj":"Q96EP0"},{"id":"T16547","span":{"begin":370,"end":374},"obj":"Q96EP0"},{"id":"T16548","span":{"begin":380,"end":384},"obj":"Q96EP0"},{"id":"T16549","span":{"begin":413,"end":418},"obj":"P29965"},{"id":"T16550","span":{"begin":539,"end":544},"obj":"P29965"},{"id":"T16551","span":{"begin":660,"end":664},"obj":"P25963"},{"id":"T16552","span":{"begin":739,"end":743},"obj":"P25963"},{"id":"T16553","span":{"begin":811,"end":814},"obj":"Q13451"},{"id":"T16554","span":{"begin":826,"end":830},"obj":"P25963"},{"id":"T16555","span":{"begin":1044,"end":1048},"obj":"Q96EP0"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"10.1371/journal.pone.0023061.g004 Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.\nCD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP). Cells were activated with CD154-expressing insect cells for the times indicated. As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only). Western blots of whole-cell lysates were probed with the indicated antibodies. Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms). IκBα blots were also reprobed for actin to demonstrate equal lane loading. Molecular weights are indicated at right. Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.\n\n"}

{"project":"test2","denotations":[{"id":"T16141","span":{"begin":44,"end":48},"obj":"Protein"},{"id":"T16142","span":{"begin":101,"end":105},"obj":"Protein"},{"id":"T16143","span":{"begin":106,"end":115},"obj":"Negative_regulation"},{"id":"T16144","span":{"begin":123,"end":127},"obj":"Protein"},{"id":"T16145","span":{"begin":164,"end":168},"obj":"Protein"},{"id":"T16146","span":{"begin":169,"end":178},"obj":"Negative_regulation"},{"id":"T16147","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T16148","span":{"begin":303,"end":312},"obj":"Negative_regulation"},{"id":"T16149","span":{"begin":364,"end":368},"obj":"Protein"},{"id":"T16150","span":{"begin":370,"end":374},"obj":"Protein"},{"id":"T16151","span":{"begin":380,"end":384},"obj":"Protein"},{"id":"T16152","span":{"begin":413,"end":418},"obj":"Protein"},{"id":"T16153","span":{"begin":419,"end":429},"obj":"Gene_expression"},{"id":"T16154","span":{"begin":531,"end":538},"obj":"Negative_regulation"},{"id":"T16155","span":{"begin":539,"end":544},"obj":"Protein"},{"id":"T16156","span":{"begin":652,"end":664},"obj":"Protein"},{"id":"T16157","span":{"begin":666,"end":671},"obj":"Protein"},{"id":"T16158","span":{"begin":739,"end":743},"obj":"Protein"},{"id":"T16159","span":{"begin":826,"end":830},"obj":"Protein"},{"id":"T16160","span":{"begin":1044,"end":1048},"obj":"Protein"},{"id":"T16161","span":{"begin":1049,"end":1058},"obj":"Negative_regulation"}],"relations":[{"id":"R12742","pred":"themeOf","subj":"T16142","obj":"T16143"},{"id":"R12743","pred":"themeOf","subj":"T16145","obj":"T16146"},{"id":"R12744","pred":"themeOf","subj":"T16147","obj":"T16148"},{"id":"R12745","pred":"equivalentTo","subj":"T16150","obj":"T16149"},{"id":"R12746","pred":"themeOf","subj":"T16152","obj":"T16153"},{"id":"R12747","pred":"themeOf","subj":"T16155","obj":"T16154"},{"id":"R12748","pred":"equivalentTo","subj":"T16157","obj":"T16156"},{"id":"R12749","pred":"themeOf","subj":"T16160","obj":"T16161"}],"text":"10.1371/journal.pone.0023061.g004 Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.\nCD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP). Cells were activated with CD154-expressing insect cells for the times indicated. As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only). Western blots of whole-cell lysates were probed with the indicated antibodies. Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms). IκBα blots were also reprobed for actin to demonstrate equal lane loading. Molecular weights are indicated at right. Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.\n\n"}