PMC:314463 / 35818-36753
Annnotations
craft-sa-dev
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In the developing limb, Engrailed1 (En1), Wnt7a, and Lmx1b are part of a network whose restricted domains of expression help to establish dorsoventral identity (reviewed in Niswander 2003). En1 is transiently expressed in the developing flank; at E11.5, transverse abdominal sections reveal domains in the neural tube, somite-derived mesenchyme, and the ventral body wall (Figure 8C). An adjacent section hybridized with Tbx15 reveals a complementary pattern in the flank, which provides additional evidence for developmental mechanisms that establish a pigmentation boundary entirely within lateral plate mesoderm and independent of lineage restrictions imposed by the lateral somitic frontier."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T6778","span":{"begin":60,"end":64},"obj":"UBERON:0002101"},{"id":"T6779","span":{"begin":65,"end":74},"obj":"UBERON:0000309"},{"id":"T6780","span":{"begin":153,"end":157},"obj":"UBERON:0002101"},{"id":"T6781","span":{"begin":258,"end":262},"obj":"UBERON:0002101"},{"id":"T6782","span":{"begin":264,"end":274},"obj":"PR:000007070"},{"id":"T6783","span":{"begin":276,"end":279},"obj":"PR:000007070"},{"id":"T6784","span":{"begin":282,"end":287},"obj":"PR:000017448"},{"id":"T6785","span":{"begin":293,"end":298},"obj":"PR:000009871"},{"id":"T6786","span":{"begin":349,"end":359},"obj":"GO:0010467"},{"id":"T6787","span":{"begin":430,"end":433},"obj":"PR:000007070"},{"id":"T6788","span":{"begin":449,"end":458},"obj":"GO:0010467"},{"id":"T6789","span":{"begin":477,"end":482},"obj":"UBERON:0000180"},{"id":"T6790","span":{"begin":505,"end":514},"obj":"UBERON:0000916"},{"id":"T6791","span":{"begin":546,"end":557},"obj":"UBERON:0001049"},{"id":"T6792","span":{"begin":559,"end":584},"obj":"UBERON:0003077"},{"id":"T6793","span":{"begin":594,"end":611},"obj":"UBERON:0017648"},{"id":"T6794","span":{"begin":645,"end":655},"obj":"GO:0097617"},{"id":"T6795","span":{"begin":661,"end":666},"obj":"PR:000016145"},{"id":"T6796","span":{"begin":706,"end":711},"obj":"UBERON:0000180"},{"id":"T6797","span":{"begin":832,"end":854},"obj":"UBERON:0003081"},{"id":"T6798","span":{"begin":918,"end":934},"obj":"UBERON:0015178"}],"text":"Because the pigmentation boundary lies in register with the limb–body wall junction (see Figure 2), we wondered whether mechanisms used for dorsoventral limb patterning might be related to those used to establish the pigmentation boundary. In the developing limb, Engrailed1 (En1), Wnt7a, and Lmx1b are part of a network whose restricted domains of expression help to establish dorsoventral identity (reviewed in Niswander 2003). En1 is transiently expressed in the developing flank; at E11.5, transverse abdominal sections reveal domains in the neural tube, somite-derived mesenchyme, and the ventral body wall (Figure 8C). An adjacent section hybridized with Tbx15 reveals a complementary pattern in the flank, which provides additional evidence for developmental mechanisms that establish a pigmentation boundary entirely within lateral plate mesoderm and independent of lineage restrictions imposed by the lateral somitic frontier."}
2_test
{"project":"2_test","denotations":[{"id":"14737183-12560810-84903015","span":{"begin":423,"end":427},"obj":"12560810"},{"id":"T17681","span":{"begin":423,"end":427},"obj":"12560810"}],"text":"Because the pigmentation boundary lies in register with the limb–body wall junction (see Figure 2), we wondered whether mechanisms used for dorsoventral limb patterning might be related to those used to establish the pigmentation boundary. In the developing limb, Engrailed1 (En1), Wnt7a, and Lmx1b are part of a network whose restricted domains of expression help to establish dorsoventral identity (reviewed in Niswander 2003). En1 is transiently expressed in the developing flank; at E11.5, transverse abdominal sections reveal domains in the neural tube, somite-derived mesenchyme, and the ventral body wall (Figure 8C). An adjacent section hybridized with Tbx15 reveals a complementary pattern in the flank, which provides additional evidence for developmental mechanisms that establish a pigmentation boundary entirely within lateral plate mesoderm and independent of lineage restrictions imposed by the lateral somitic frontier."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6858","span":{"begin":12,"end":24},"obj":"GO_PATO_EXT:biological_pigmentation_process_or_quality"},{"id":"T6859","span":{"begin":60,"end":64},"obj":"UBERON:0002101"},{"id":"T6860","span":{"begin":65,"end":74},"obj":"UBERON:0000309"},{"id":"T6861","span":{"begin":153,"end":157},"obj":"UBERON:0002101"},{"id":"T6862","span":{"begin":158,"end":168},"obj":"GO_PATO_EXT:biological_patterning_process_or_quality"},{"id":"T6863","span":{"begin":217,"end":229},"obj":"GO_PATO_EXT:biological_pigmentation_process_or_quality"},{"id":"T6864","span":{"begin":258,"end":262},"obj":"UBERON:0002101"},{"id":"T6865","span":{"begin":264,"end":274},"obj":"PR_EXT:000007070"},{"id":"T6866","span":{"begin":276,"end":279},"obj":"PR_EXT:000007070"},{"id":"T6867","span":{"begin":282,"end":287},"obj":"PR_EXT:000017448"},{"id":"T6868","span":{"begin":293,"end":298},"obj":"PR_EXT:000009871"},{"id":"T6869","span":{"begin":349,"end":359},"obj":"GO:0010467"},{"id":"T6870","span":{"begin":430,"end":433},"obj":"PR_EXT:000007070"},{"id":"T6871","span":{"begin":449,"end":458},"obj":"GO:0010467"},{"id":"T6872","span":{"begin":477,"end":482},"obj":"UBERON:0000180"},{"id":"T6873","span":{"begin":505,"end":514},"obj":"UBERON:0000916"},{"id":"T6874","span":{"begin":546,"end":557},"obj":"UBERON:0001049"},{"id":"T6875","span":{"begin":559,"end":584},"obj":"UBERON:0003077"},{"id":"T6876","span":{"begin":594,"end":611},"obj":"UBERON:0017648"},{"id":"T6877","span":{"begin":645,"end":655},"obj":"GO:0097617"},{"id":"T6878","span":{"begin":661,"end":666},"obj":"PR_EXT:000016145"},{"id":"T6879","span":{"begin":706,"end":711},"obj":"UBERON:0000180"},{"id":"T6880","span":{"begin":794,"end":806},"obj":"GO_PATO_EXT:biological_pigmentation_process_or_quality"},{"id":"T6881","span":{"begin":832,"end":854},"obj":"UBERON:0003081"},{"id":"T6882","span":{"begin":918,"end":934},"obj":"UBERON:0015178"}],"text":"Because the pigmentation boundary lies in register with the limb–body wall junction (see Figure 2), we wondered whether mechanisms used for dorsoventral limb patterning might be related to those used to establish the pigmentation boundary. In the developing limb, Engrailed1 (En1), Wnt7a, and Lmx1b are part of a network whose restricted domains of expression help to establish dorsoventral identity (reviewed in Niswander 2003). En1 is transiently expressed in the developing flank; at E11.5, transverse abdominal sections reveal domains in the neural tube, somite-derived mesenchyme, and the ventral body wall (Figure 8C). An adjacent section hybridized with Tbx15 reveals a complementary pattern in the flank, which provides additional evidence for developmental mechanisms that establish a pigmentation boundary entirely within lateral plate mesoderm and independent of lineage restrictions imposed by the lateral somitic frontier."}