PMC:3091637 / 2726-4007 JSONTXT

{"project":"2_test","denotations":[{"id":"20642828-10101183-10659290","span":{"begin":244,"end":245},"obj":"10101183"},{"id":"20642828-8536978-10659291","span":{"begin":523,"end":524},"obj":"8536978"},{"id":"20642828-10666709-10659291","span":{"begin":523,"end":524},"obj":"10666709"},{"id":"20642828-16126659-10659291","span":{"begin":523,"end":524},"obj":"16126659"},{"id":"20642828-15865975-10659292","span":{"begin":621,"end":622},"obj":"15865975"},{"id":"20642828-16360323-10659293","span":{"begin":623,"end":624},"obj":"16360323"},{"id":"20642828-10441671-10659294","span":{"begin":1059,"end":1061},"obj":"10441671"},{"id":"20642828-15525697-10659294","span":{"begin":1059,"end":1061},"obj":"15525697"}],"text":"Animal mitochondrial (mt) genomes typically consist of a circular molecule of DNA encoding 37 genes (2 rRNA genes, 13 protein-encoding genes, and 22 tRNA genes), the arrangement of which is often highly conserved within major taxonomic groups [1]. Consequently, when gene rearrangements occur, they may provide compelling phylogenetic markers that can corroborate or contradict hypotheses based on primary sequence data and provide resolution for deeper nodes that are often weakly supported in sequence-based phylogenies [2-6]. With recent technological and methodological advances (e.g., rolling circle amplification: [7,8]; next generation sequencing technologies: [9]), and associated decreasing costs of DNA sequencing, the amplification and sequencing of whole mt genomes has become routine. As a result, there has been a marked increase in the sequencing of whole animal mt genomes over the past decade as well as the development of computational methods to extract phylogenetic information from these genomes through inferences of past gene dynamics [10-12]. To date, 1868 complete metazoan mt genomes are available in the NCBI Genomes database http://www.ncbi.nlm.nih.gov/guide/genomes/; January 8, 2010), the majority belonging to arthropods (293) and vertebrates (1292)."}