PMC:3023298 / 84305-85128
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3023298","sourcedb":"PMC","sourceid":"3023298","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3023298","text":"PD is a chronically progressive, age-related, fatal neurological disease in humans described first by James Parkinson in 1817. Estimates indicate that 4 to 6 million people have been diagnosed with PD. It affects about 2% of the population at some time in life. The greatest prevalence occurs in the USA, with between 100 and 250 cases per 100,000 [315], placing PD as the 2nd most common neurodegenerative disease with an adult onset (after AD). Progressive resting tremor (4–7 Hz), rigidity, bradykinesia/akinesia, gait disturbance, and postural instability characterize PD clinically [316]. The disease progression is also associated with mood disturbances, dementia, sleep disturbances, and autonomic dysfunction [316]. There are currently no cures for PD. Medications and neurosurgery can relieve some of the symptoms.","tracks":[{"project":"2_test","denotations":[{"id":"21258649-18344392-83670177","span":{"begin":588,"end":591},"obj":"18344392"},{"id":"21258649-18344392-83670177","span":{"begin":588,"end":591},"obj":"18344392"},{"id":"21258649-18344392-83670178","span":{"begin":718,"end":721},"obj":"18344392"},{"id":"21258649-18344392-83670178","span":{"begin":718,"end":721},"obj":"18344392"},{"id":"T37417","span":{"begin":588,"end":591},"obj":"18344392"},{"id":"T72932","span":{"begin":588,"end":591},"obj":"18344392"},{"id":"T43458","span":{"begin":718,"end":721},"obj":"18344392"},{"id":"T18541","span":{"begin":718,"end":721},"obj":"18344392"},{"id":"T87914","span":{"begin":588,"end":591},"obj":"18344392"},{"id":"T49152","span":{"begin":588,"end":591},"obj":"18344392"},{"id":"T35917","span":{"begin":718,"end":721},"obj":"18344392"},{"id":"T97567","span":{"begin":718,"end":721},"obj":"18344392"}],"attributes":[{"subj":"21258649-18344392-83670177","pred":"source","obj":"2_test"},{"subj":"21258649-18344392-83670177","pred":"source","obj":"2_test"},{"subj":"21258649-18344392-83670178","pred":"source","obj":"2_test"},{"subj":"21258649-18344392-83670178","pred":"source","obj":"2_test"},{"subj":"T37417","pred":"source","obj":"2_test"},{"subj":"T72932","pred":"source","obj":"2_test"},{"subj":"T43458","pred":"source","obj":"2_test"},{"subj":"T18541","pred":"source","obj":"2_test"},{"subj":"T87914","pred":"source","obj":"2_test"},{"subj":"T49152","pred":"source","obj":"2_test"},{"subj":"T35917","pred":"source","obj":"2_test"},{"subj":"T97567","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e393ec","default":true}]}]}}