PMC:3023298 / 106714-107343
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3023298","sourcedb":"PMC","sourceid":"3023298","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3023298","text":"Mitochondrial pathology in A53T mice involving mitochondrial DNA damage is seen frequently in the absence of nuclear DNA damage in large brainstem neurons and spinal motor neurons [395]. Subsets of mitochondria in brainstem and spinal cord cells in A53T mice appear dysmorphic, becoming shrunken, swollen, or vacuolated [395]. Human α-Syn is found bound to some mitochondria in degenerating neurons in A53T mice [395]. Some abnormal intracellular inclusions in these cells are degenerating mitochondria. A mitochondrial defect in A53T mice is further indicated by biochemical evidence revealing loss of complex IV activity [395].","tracks":[{"project":"2_test","denotations":[{"id":"21258649-16399671-83670293","span":{"begin":181,"end":184},"obj":"16399671"},{"id":"21258649-16399671-83670293","span":{"begin":181,"end":184},"obj":"16399671"},{"id":"21258649-16399671-83670294","span":{"begin":321,"end":324},"obj":"16399671"},{"id":"21258649-16399671-83670294","span":{"begin":321,"end":324},"obj":"16399671"},{"id":"21258649-16399671-83670295","span":{"begin":413,"end":416},"obj":"16399671"},{"id":"21258649-16399671-83670295","span":{"begin":413,"end":416},"obj":"16399671"},{"id":"21258649-16399671-83670296","span":{"begin":624,"end":627},"obj":"16399671"},{"id":"21258649-16399671-83670296","span":{"begin":624,"end":627},"obj":"16399671"},{"id":"T50829","span":{"begin":181,"end":184},"obj":"16399671"},{"id":"T49655","span":{"begin":181,"end":184},"obj":"16399671"},{"id":"T52423","span":{"begin":321,"end":324},"obj":"16399671"},{"id":"T51203","span":{"begin":321,"end":324},"obj":"16399671"},{"id":"T1782","span":{"begin":413,"end":416},"obj":"16399671"},{"id":"T3132","span":{"begin":413,"end":416},"obj":"16399671"},{"id":"T28388","span":{"begin":624,"end":627},"obj":"16399671"},{"id":"T53334","span":{"begin":624,"end":627},"obj":"16399671"},{"id":"T80025","span":{"begin":181,"end":184},"obj":"16399671"},{"id":"T34494","span":{"begin":181,"end":184},"obj":"16399671"},{"id":"T95980","span":{"begin":321,"end":324},"obj":"16399671"},{"id":"T21307","span":{"begin":321,"end":324},"obj":"16399671"},{"id":"T1368","span":{"begin":413,"end":416},"obj":"16399671"},{"id":"T57025","span":{"begin":413,"end":416},"obj":"16399671"},{"id":"T16361","span":{"begin":624,"end":627},"obj":"16399671"},{"id":"T75696","span":{"begin":624,"end":627},"obj":"16399671"}],"attributes":[{"subj":"21258649-16399671-83670293","pred":"source","obj":"2_test"},{"subj":"21258649-16399671-83670293","pred":"source","obj":"2_test"},{"subj":"21258649-16399671-83670294","pred":"source","obj":"2_test"},{"subj":"21258649-16399671-83670294","pred":"source","obj":"2_test"},{"subj":"21258649-16399671-83670295","pred":"source","obj":"2_test"},{"subj":"21258649-16399671-83670295","pred":"source","obj":"2_test"},{"subj":"21258649-16399671-83670296","pred":"source","obj":"2_test"},{"subj":"21258649-16399671-83670296","pred":"source","obj":"2_test"},{"subj":"T50829","pred":"source","obj":"2_test"},{"subj":"T49655","pred":"source","obj":"2_test"},{"subj":"T52423","pred":"source","obj":"2_test"},{"subj":"T51203","pred":"source","obj":"2_test"},{"subj":"T1782","pred":"source","obj":"2_test"},{"subj":"T3132","pred":"source","obj":"2_test"},{"subj":"T28388","pred":"source","obj":"2_test"},{"subj":"T53334","pred":"source","obj":"2_test"},{"subj":"T80025","pred":"source","obj":"2_test"},{"subj":"T34494","pred":"source","obj":"2_test"},{"subj":"T95980","pred":"source","obj":"2_test"},{"subj":"T21307","pred":"source","obj":"2_test"},{"subj":"T1368","pred":"source","obj":"2_test"},{"subj":"T57025","pred":"source","obj":"2_test"},{"subj":"T16361","pred":"source","obj":"2_test"},{"subj":"T75696","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#eca093","default":true}]}]}}